THE NEW VALUABLE ALKALOID LAGOCHILINE

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP82-00039R000200140025-8
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 4
• Document Creation Date: December 22, 2016
• Document Release Date: March 26, 2012
• Sequence Number: 25
• Publication Date: September 18, 1952
• Content Type: REPORT

Declassified in Part - Sanitized Copy Approved for Release 2012/03/26: CIA-RDP82-00039R000200140025-8
,
The New Valuable Alkaloi La ochilr_le
by A. A. Shamshurin
Priroda, Vol XL, No?, p 57, Jul 51
Russian MD. Per.
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The Soviet science of alkaloids discovers and initiates
the study of more and more new alkaloids derived from uncultivated
raw materials. Some of them are of great interest in clinical
practice.
Among the new alkaloids discovered in recent times, the so-
called "lagochiline" was found to be mo st interesting due to its
pronounced hemostatic properties. Lagochiline was discovered in
the uncultivated, thorn-bearing shrub, Qeilus inebrias Bge
(Family of Labiates-Labiatae) by the Tashkent chemists G. V.
Lazurlyevskiy and A. S. Sadykov as early as 1939 (3), but the study
of its chemical nature is only now being undertaken (1).
Labiates were hitherto of interest mainly as essential oil
yielding plants, and it is only at present that Soviet chemists
are finding in representatives of this family new alkaloids, for
three of which betonicine, stachydrine, and trigonelline --
the structure has already been established. These alkaloids con-
tain the betaine grouping with a pentavalent nitrogen.
Lagochilus grows on rocky soil, and is found over small
areas primarily within the Samarkand and Bukhara ()blasts of the
Uzbek SSR. Lagochilin is contained in the above-ground portions
of this plant in amounts up to 0.5 percent. It is extracted with
dichlorethane from the Edified raw material, and from the total
extract obtained on neutralization of an acidic infusion with al-
kali, and crystallizes from water or aqueous alcohol in the form
of colorless needles. The melting point is between 106 and 107
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Declassified in Part - Sanitized Copy Approved for Release 2012/03/26 CIA-RDP82-00039R000206140025-8
degrees Centigrade.
The empirical formula of lagochiline has been found to be
C22H40203 ? H20. On removal of the water of crystallization the
base melts at 151 to 152 degrees Centigrade.
Lagochiline is optically inactive and is a very weak base
which is incapable of forming salts with mineral acids. It is
soluble only in strong acids and does not yield an iodine methy -
late. These data justify the inclusion of lagochiline among alka-
loids having a betaine grouping. In addition to lagochiline, lago-
chilus also contains other alkaloids such as inebrin not yet
investigated even in a preliminary manner.
As has been demonstrated by pharmacological studies conduc-
ted at the pharmacological department of the Samarkand Medical
Institute imeni Academician I. P. Pavlov, by the department head
I. E. Akopov and associate I. I. Ibragimov (2), lagochiline prepara-
tions and extracts of lagochilus display very pronounced hemostatic
properties on intravenous or subcutaneous administration to experi-
mental animals -- mice, rats, rabbits, dogs, and cats. Tine res
of lagochilus have been tested by the authors also in the course
of self-administered treatments and were thus found to be non-toxic
to man within certain dosage ranges. In experiments with mice in
which .41e tails of experimental animals were cut off following a
subcutaneous injection of lagochiline, hlEiThages were decreased
and their shortened by 10 to 20 times and even more, in contrast
with control animals having received prior to amputation of the
tail only an injection of physiological saline solution.
;?-d
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1, M Abramov and G. V, Lazurlyerskiy. Doklady Akademii Nauk,
Uzbek SSR. 10, 1948.
Zhurnal. No. 9 1950.
3. G. V. Lazurlyerskiy and A. S. Sadykov. Trudy of the Uzbek
State University. 15, 1939.
A. A. Shamshurin
Declassified in Part - Sanitized Copy Approved for Release 2012/03/26: CIA-RDP82-00039R000200140025-8