SCIENTIFIC ABSTRACT GRAYEV, M.I. - GRAYEVSKIY, A.I.

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• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

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and ooVlots llnear group ord the ~~*cla rmaticne relrited to
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Krilins (Central Rorniff.-I.IrAMT."MR-er lust.,
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i"i.
Leningrad). 11yull-Ekipd. .23 3;k4-42(1947)
06" -X-ray irradiation ad dog brain. at 100 kv., at 23-mm.'
- distance by "ng 0.6 Cu-3.0 At Wier, each dog receiving a
008 total of 5 unit shin doses of irradiation in 4 QxS I I s
411104 willsafternatc leTadiation of the riaht awt the kft Was
no bloon tusew (fcsmwW artery and sinu% verso&w cerebri).
00 1 3pinal duMwjp&r. b1foud 34-Fum protrin, and tht altainsin-
glaboM fractitavs tit Or Law. As the total irvialistion
increawd. tbv toW rrnttei protein tow until on the Mh
day (after the Ist iifwlialion) it reached 2001 of the iml-
0013
-tialvalue. In the same period thealhumin I;Zioa
000 1by only M% for arter W, and 32% for venous Wood. while
00.9 1tt!=Iractkmrcoe3L'4iuui3M',',.resp. Tbeaks.
ia t cm in the ~%pinal duid firnmWed withim capd.
00" vwktion%. but it% alliumin/slobulitt ratio gradually
001 changed to 1.0 front 0.56. Arterial blood stugar rentainetl
normal, but it fell in the venotm blood, until the mqw
004
utilisation by the lwain at the FA)-day period was 370% of
jititiij. SpiW duid migar 4W not itacrow. The chsagn
are ascribed to a v,A"JAI 16welfing of the brAin MN, with
deernwied amt. of intracell"Llf fluid,. G. lit, K.
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BLOKHDI, N.F.; GRAYEVSKAYA, B.M.; KEYLIKA, R.Yn.
Bioch"emlenl functionnl test In certnin forms of hypertertaton.
Vop.med.khim. 3:52-57 151. (MIRA 11:4)
1. Otdel biokhimij TSentrallnogo rentgenologicheskogo, rndiologichesko-
go 1 rnkovogo Institutn. Leningrad.
(HYPISMS ION)

IF 1
7-

A
44
1.
ill Orateb mets'"lism in animal orgaftisin -
kftar locAl and getteral X-ray irradiation., - B. M. Graevskaya
-,.(Central Roentgenol.-Radial., Znst..'Ministry Health, Mm,
Veitnih Rjille al. i Radid. 103. No. 6 9-14--~_
cow).
Local x-irradUtion of either trunslocatcd kidney (1,400-r,
'c losage) or imminal gUmt (40-150 r. dosag(-) in d0g% Mjilrd-
:I m of the mode of radiation (single or multiple txptmires),,
'l ed to certain definite metabolic changes. The dry tuatter
~of tht'blood (arterial and (fiat flowing front the brain) dro q,
!(Or,5-7 days, then risti to normal kvcl. Serum protX,
Chemical Abst. t 7-10 days, in the arterial blood; fit the

Vol, 48 -go. 6 the brain . brief rl,,c in sseruin protein I!;
c ,at blood 1,
di
ll
li
f
5
7 d
G
l i
i
f
b
d

Mar. 25, 11954 -
enera
o
ec
ne a
ter
rra
at
on
a
ays.
y a
1 r. close) was tried, but animals with 1000 r. do.-;-

Biological-ChemistrY died and the. res. ults were estd. from specimens rectiving'
h
l N I
l
Af
48 h
i
i
f t
th
ter
ere
se o
e
ower
rs. t
s a r
ota
n
bf =.big at high level for 60 days; usually the N of.
~the venous bl Is room affected than that of artetial blood,:
Indleating protein lirrMalown in' the muscle tissues, . At 3W
'r. dosage the protein level drops to norinal in 25 days. at
'M r. dosage a brief drop In residu3l N is observed, followed;
~,by a rise Avith a max. tit 25 days~ returning to flortnal In W, -
days~ If th-1 animal is irradiated with screculuir bf-tht
head, the urea ltvvt riscs in 1~2 days by 300%, remains higli
for 20-1 days then slowly returns to normal. Thii- total
solids of the bl;Dod vaso rLe and do not rrturn to norriuil for
!neazly~ 100 days. The ash content of the blood dedines.
'then rises to,supernormal limits and continues to nse P-ven
'
U
ter 100
dayi. A IOMr. dosage (lethal after 50 days)
Causes a drop in total IN after 25 days. followed by a rise to
bormal level by the 50th day when death casuei. - Urea
clints at first, slightly, and the decline persists for 24 days,
-and is followed by a slowrisc.

VSSR/Medicine - Radiation Effects Nov/Dec 53
"Effects of Aneurin (Vitamin B,) on the Glycogen
Formation Function of Liver of Rats During General
Exposure to Various Doses.of X-Rays,"~ B. M- Grayeve-
skaya~Y-'-R. Ya. Keylina, ana~S. E. Manoylov,"Dept of
Blocbem, Central Roentgenologic and Cancer Inst,
Min of Health USSR
Vest Rentgen i Radiol, No 6, pp 22-25
Expts conducted on 15 rats showed that the glycogen
formation function of the liver may be partially
restored if vitamin B I is given after rats have
275T31
been exposed to X-rays. Enough evidence was col-
lected to justify the assumption that the quality
of biochem changes in the organism of rats depends
upon the extent of exposure to X-rayst small doses
(500 r) of X-rays suppress I.-he oxidation systems of
the whole organismi larger doses (1,000 and 2,000 r)
also cause breakdown.. of the substances that
,oxidize. It is possible that interference with the
sy~athesis of the dehydrogenase coenzyme takes place
and that vitamin B loses its capacity to combine
vith phosphoric acid. This follows from a reduc-
tion of the restorative effect of vitamin BI on the
liver.

GRA)WSKAYA, B. M.
"Concerning the Problems of the Comparative Evaluation of the
Effect of Gamma-Radiation of Radioactive Cobalt and Roentgen
Rays on Certain Aspects of Protein Metabolism of the Liver of
Rats,1' by B. M. Grayevskaya, Lecheba2ye.Primeneniye Radioactiv-
.~alta (Therapeutic Use of Radioactive Cobalt), Moscow,
Medgiz, 1955, pp 36-37 (from Referativnu Zhurnal -- Kbimiya,
Biologicheskaya Khimiya, No 16, 25 Aug 56, Abstract No 15779)
It was proved that total irradiation of rats by 500 r decreases the
activity of proteinases (rise of N112 - 11 after 4-hour incubation at 37o C
and pH 4), by 60% after 2 days' incubation of the homogenate, and by 3%
after 4 days of incubation, as compared with the nonirradiated controls.
The-same dose of gamma rays of C060 activated autolysis by 24 in 2
days and 73% in 4 days.
1.157

'.GRAY11ySmy-A. B.H.; KOHONENKO, A.M.; MAKOYLOV, S.S.
Distribution of radium in the body of a rat and itB excretion rate.
Vest.rent. I red. no.2:io-i6 mr-Ap 155- (MLRA 8:5)
1. 1z biokhimicheskogo otdolentya (zav.--prof. S.Te.Manoylov) t
radiologichookogg otdalenlya (zav. A.A.Bashilov) Teentrallnogo
nauchno-isoledovatellskogo rantgano-radiologichaskogo inetttuta
(dir.--prof. K.N.Pobedinskiy) Ministerstva zdravookhranentya SSSR.
(RADrUM, metabolism,
diet-ribution & excretion rate In rats)

f 9.
1~,-'Alteridbns La carb6h.kdrate inetabo!Um llifter1ray It-
~Jilldldtif)n Of total Otl!UW Crggnh=. - B. H. Gracvtkavia and
R. Va. Kellina. 1esixib Rentgtud. i "Wi 105f No- 4,
21-6.-TOtal-animitl (dogs) -bridiativ4 =4el d" , ,,
;.. , -
liver fonqtion alld: distUbcd rtspovss to.Mrcja
-W
glueose. Atatiblethal (JOQ 4 r,) iijid-10hal (I(JC9) t.)
the glycemic cbries, after treatmezt -with- adretialmL wid
zlucose are dlffd&ati In tile Itt instance they have shulbw
ith -a hyberglyceruid epeff. 1.1-1.2. while in thc 2nd
L
they ti~rve tile diabetic character (eaeff.
After such irr;tdiatiot. tilcr4 is at fir5t a coitiidmble drzp 21
sugar Utilixation by the bn*dli. whilcldlAtcr stagei ther,
occurs an actug elimination ofsugar by tile brain wq imnitt in
the outflowing blood, whIJi U nevd, ollsesved in
animals. At the low-dose lev&the animals c,,mb,,t the
injury and are restored in- same 4 days; at high levels of
irradiatidn the process is Irreversible and the gl$cogen-farm-
ing Ionction o.* the liver is impaired for We~

Chnnic actIon_bLUAu&u-u1LLoa the aninud argaam.
V
S. R. Manallov -V1-,1&raPvsk3,~2.aud.K. B. Shimanov. Dept. Biochem.!&
skaya (Centrai I. esearc oentgen-Radiol. last"
Ministry Health U.S.SX., Moscow). Yestaik Rentgenol. I 2nd Diagnostic. OI'LJce
Radicl. tgSS. No. 61 43-9.-Parenttral introduction of
RaBri at 10-1 c. dasage camed IW70 mortality in rats, with 11-14~
characteristics of radiation sickness Wing evident. At
2 X 10"'* c dosage, no mortalities took place, and interme.
diate dosi;; gave corresponding expected results. P" at
1.76 X 10-1 c. or highy dose 11 100% lethal in 0-15 days.
Sublethal and intermediaw doses of R:tBrt tend to produce
increased levels of liver glycogen. Protcalytic activity of
liver tissue at moderate exposure to RaUrs declines at first,
then rises after some 44 days to 160V/0 of normal. At high
doses of P't the liver glycogen drops markedly in 2-3 days;
very high doses cause a~vcry abrupt and severe drop. The
proteolytic activity of the liver is only sliKhtly affmted by
low doses anti is lowered by high doses of P"'. Introduction
of l1alits (2 X 10"I c.) Into the bone cavity of a rut five
inconclu3ive results, baZ III U. rabbit after some 15 months it
Yras shown that a bone -sarcom;A had developed, with can-
siderable metastasig. 0. M. Kosolajaff_

"M,-

4

-091. SUIAWM-bs won IntaWtv of X-say radi I
at an "a Mat
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,
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DiV1,1056, AWr. -No. MOW-Thn effect of Jntwoi y of
ow'th,* tiegrea of
chAnga of carboll
drute metaix)L-kall In
.
y
Itradiat6d orkaldsm was studied. Rats were irradiated with 600a
75a6 x and 26.2 it per wind As 'an ifidicntor of the chavip of
'
'
s
-
' rl
th
li
i
l
lis
t
h
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s use"
-'
ver vrA
io
it
e
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i t
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i
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,
t
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o
ate
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nan tuN itra
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irn
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e-
an
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o sania
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ow,
but at MC MtO Of 26-12Vt IV& Mill. SKI

led? C'_/

11.) R. Y A,
_"CbAn`ge,of'Carbdbydr&te Metabolism Due to Total Irradiation
of an Animal Organism by X Rays," by B. M. Grayevskaya and
. a. eym n oprosy Radiob -CPF6~
Y K i a, V iologii blems ~ofRa~o_
R
biologyJ',Leningrad, 1956, pp 352-35-6 (from Referativnyy
Zhurnal -- Khimiya, Biolo5icheskaya Khimiya, No 24, 25 Dec
5b, p dO, Abstract No 23449)
Subcutaneous injections of adrenalin to dogs who were subjected to
total irradiations by 300 to 500 r did not cause increased blood glucose
content. Liver glycogen content decreased 80% in 48 hours after irradl-
stion.
Glucose administration caused no glycogen synthesis in the liver-of
rats vbQ --W'be*u va'03"W to 500- .1000 -or
2,=
SUM. 1282

GRAYIVSKAYA, B.M.; XEYLINA, R.Ya.
Decrease in the sensitivity of animal@ to fatal doses of I rays
following irradiation with nonfatal doses. Biofizilm l.no-3:
232-236 '56. (MLRA 9:9)
1. ?Sentralinyy nauchno-inaledovatellskiy rentgeao-radiologichookly
institut Ministerstva sdravookhronaniya SSSR. Leningrad.
(I RAYS --PHYS IOLOGICAL AFFWT)

S'rx- f
SUBJECT USSR PHYSICS CARD I / 2 PA - 1336
AUTHOR GRAEVSKAJA, B.M., ORLOV, B.A.
TITLE On the Premature Changes in the Serum of the Blood found to
occur by the Method of Ultraviolet Spectrography in the Case of
an Integral Effect Exercised by X-Rays.
PERIODICAL Dokl.Akad.Nauk, 108 ', fasc-4, 623-625 (1956)
Issued: 8 / 19~_6 reviewed- 10 / 1956
Parallel with spectroscopic investigations also the content of amino acid of
thyrocine in the serum of the blood of the irradiated animals was determined.
30 white rats, 5 rabbits, and 12 dogs were examined, and the respective results
were essentially in agreement. The animals were exposed to the integral effect
of X-rays on the following conditions: 190 KV, 20 ma, filter 0,5 mm Cu and
1,0 mm Al. The dogs were irradiated with a skin-focus distance of from 80-100
cm. with a dosage of 6,5-11r per minute, Radiation doses were: 130, 500 and
1000 r for dogs, 1000 r for rabbits, and 500 and 1000 r for mice.
In the course of the experiments undertaken with dogs, before and immediately
after irradiation, as well as after 2, 7,i 14, 21, 33-40 and 90 days after
irradiation A-5 ml blood was extracted from the femoralis artery. The serum ob-
tained was diluted 8-fold in distilled wate= and spectrographed in the ultra-
violet domain of the spectrum. The absorption maxima of the serum of normaj-
animals is between 2800 and 2920 1 In the case of an irradiation with 1000 (or
500) r the absorption maximum is considerably (or noticeably) reduced at 2800 -
2920 A immediately after irradiation, In the case of dogs irradiated with 130 r

lDokl.Akad.Nauk, 108, fasc-4, 623-625 (1956) CARD 2 / 2 PA - 1336
no changes were noticeable immediately after irradiation, and only on the
'second day a certain decrease of the UV absorption of the serum was found with-
in the domain of the maximum. After 33 days a rertain increase of the optical
density of the serum occurred, which was not noticed if lareer doses were
given, This increase is probably a compensation effect.
Parallel with spectrographic investigations a considerable reducti-:Pn of the
thyrocine content in the serum was found by the method developed by CUVERKALOV
immediately after irradiation with 1000 or 500 r. With animals that remained
alive (500 r), but not with animals that died (1000 r), the thyrocine content
after some time again attains its normal level. In the case of relatively small
doses (130 r) the thyrocine content decreased only after some days by about
10% and increased again after a period of 30 - 33 days after irradiation.
A certain parallelism between the modifications of the optical density and of
the thyrocine content' of the serum makes it appear probaile that these modifi-
cations are connected with previous disintegraTing processes in albumen meta-
bolism. These results show that it is possible to use the spectrographic method
for the detection of previous damage caused by irradiation.
The method discussed is of great importance for the timely diagnosis of
radiation thickness.
INSTITUTION: Central Radiological and Cancer Institute of the Ministry for
Health in the USSR.

USSR / Human and Animal Physiology. Effect of Physical Factors T-13
Abe Jour : Ref Zhur - BiologiYa, No 1, 1959, No- 3968
Author : Grayevskayn, B. M.; Keylina, R. Ya
Inat : Not given
Title : The Decrease of Sensitivity of Animals to the Effect
of Roentgen Rays in a Lethal Dose by Their Preliminary
Irradiation with Non-Lethal Doses
Orig Pub : Tr. Vaes. konforentail po mod. radiol. Eksperim. med.
radiol. X., Medgiz, 1957, 183-185
libstract : The survival of animals subjoctod to a total Irradiation
of 1000 r (lothal doeo) constituted roopoctively 50 nncl
100~ 150 days (34 rats) and 120 - 150 days (8 dogs)
after preliminary Irradiation with a dose of 500 r.
Repeated action, as diffore-ittated from a single action
in the same dose,, was accompanied by a lose sevoro symp-
tomatology and did not lead to a decroaso of Hb contont
Card 1/2
127

LBW / Human and Animal Physiologr - Effect of Physical Factorj. T-13
Abe Jour Rof Zhur - Biologiya, No 1, 1959, No- 3968
and HSR. The change of the glycomic curve of glucose
content according to the diabetic tnv was lose than in
a single irradiation with the same doso. Prior to
repeated irradiation, hyporglycomic effect on load
content lessor than that beforo the first irradiation
offoct and a greator contant of total and residual N
and uroa in blood was discovorod. -- 0. Ya. Toreshchomko
Card 2/2

GRAUVSUYA, B.M. -
Effect of total body irradiation on autolytic processes in
the liver and spleen of rats. Yop.radiobiol. 2:114-121
'57. ' (MIR& 12:6)
1. SotriAnik TSentrallnogo nauchno-looledovatellskogo rentgeno-
radiologichoskogo inBtituta Ministeretva 2dravookhraneniya Sm.
(AT,720LYSIS) (VISCM&) (1tkDIkTIoN--PHYSIoLOGICAL XFMT)

M&NOYLOV, S.Ye.,- GRAUVSKAYA. KEYLINA. R.Ya.
wmww~ -
Use of some biologtcal preparations (campolonum, vitamin B1
and adenosinetriphoophoric acid) as prophylactic and therapeutic
drugs In radiation sickness. Vop.radioblol. 2:426-43o '57.
(KIRL 12:6)
1. Sotnidniki ?Sentrallnogo nauchno-ii;sledovatellskogo rentgeno-
rudiologicheskogo instituta Ministeratva zdravookhraneniya SSR.
(VITAIIINS--B) (ROIATION SICMSS) (ADENOSIIIXTRIPHOSPHORIC ACID)

GRAYEV9KAYA, B.M., IMYLINA R.YA.
--------- ~-j
With regard to I.G. Krannykh find B.P. IAmonenko's letter published
in "Blofisika". Biofisika 3 no.4:527-528 '58 (mi~j 11:8)
(I RAYS--MSIOWGICAL EFFECT)

GRAYJIVS UYLIM, R.Ya.
Role of the adrenals in certain metabolic disorders in irradiated
organism. Med. rad. 4 n0-3:21-25 Mr '59. (KIPA 12:7)
1. Iz otdela biokhimii (zav. - prof. S.Ye. Manoylov) TSentral'UogD
nauchno-iseledovatellskogo rentgeno-radiologicheskogo instituta
Ministerstva sdravookhraneniya SSSR.
(ROENTGEN RAYS, effects,
on carbohydrate & protein metab., eff. of adrenalectomy
(Rue))
(CAN.BOHYMTI, metab.
eff. of x-rays in adrenalectomized animals (Rus))
(PROT319, metab.
same)
(ARYMMUCTOMY, effects,
on carbohydrate & protein metab. responses to x-rays
(RUB))

24(0)
AUTHOR: Grayevskaya, B. M. SOV/2o-124-1-58/69
TITLE: On the Way the Content of Glycogen in the Liver is Affected
by Ionizing RaOiation (0 mekhanizme vliyaniya ioniziruyushchey
radiatsii na 3oderzhaniye gliko,-ena v pecheni)
PERIODICAL: Doklady Akademii nauk SSSR, 1959, Vol 124, lir 1,
pp 2o2 - 204 (USSR)
ABSTRACT: One of the most marked and soon occurring reactions of
organism upon ionizing raoiition is a di.9turbance of the
carbohydrate metabolism. This refers in particular to
changes of the glycoeen content in the liver. The nature
of these chan.' :es has remained unclarified and the individual
research workers are of contradictory opinions. The nuthor
wanted to find whether: a) this is due to neurohumoral
effects (Refs 1,2), or b) to the fact that the experimental
anii-nals had to suffer hunger in consequence of a more
difficult absorption of nutritive substances from the
intestines and reduced food intake (Ref 6) or finally c) to a
direct effection of irradiation of the liver tissue. Por
Card 113 this purpose the changes of the glycogen content in the

On the "Way the Content of Glycogen in the Liver is SOV/2o-124-1-58/69
Affected by Ionizing Radiation
liver were investigated at: 1) X-ray total irradiation,
II) Local irradiation of the liver region and III) A
screening off of the liver region of the mice (3 mm lead
plates were used as screens) during total irradiation.
Survival changes in weight and the amount of leucocytes
were observed during 30 days after irradiation. Group IV
served as a control group. 4 days after irradiation the
animals were killed and the glycogen content in the liver
was determined according to PflUger (Pflyuger). The experimen-
tal results are given (Table 1). 1) After total irradiation
(600 r) the glycogen content drops more than 50%. 11) Also
a local irradiation of the liver results in a marked
decrease of the glycogen content. III) The screening off of
the liver region did not bring about any real changes of the
glycogen content. Total irradiation with 600 r caused the
death of 50% of the animals after 30 days. Among the animals
with a locally irradiated liver and those exposed to total
irradiation with screened off liver were no fatal cases. The
changes in weight and the peripheral blood count show (Fig 2)
Card 2/13 that total irradiation has the most serious effect upon the

On the Way the Content of Glycogen In the Liver is SOV/2o-124-1-58/69
Affected by Ionizing Radiation
animals. In the cases where the liver was screened off the
damage was less serious. The least damage suffered those
mice that were irradiated in the liver region only. The most
striking changes of the glycogen content are, however, observed
in the case of total and local irradiation of the liver. Thus
it can be said that the author did not observe a clear rela-
tionship between the glycogen content in the liver and the
state of the irradiated organism as a whole. This permits
the conclusion that the changes of the glycogen content in
the liver of irradiated animals are widely determined by a
direct effect of radiation upon the liver tissue. There &Ye
2 figures, 1 table, and 6 references, 2 of which are Soviet.
ASSOCIATION: Institut genetiki Akademii nauk SSSR (Institute of Genetics,
Academy of Sciences ;USSR)
PRESENTED: August 2, 1958, by T. D. Lysenko, Academician
SUBMITTED: August 1, 1956
Card 3/3

17. (4) , 21 (3)
AUTHOR: Grayevskaya, B. M. SOY/20-126-4-51/62
TITLE: Relaxwbion of Glycogen-content Alterations in the Liver Owing
to Ionizing Radiation During the Irradiation of Animals in a
Carbon-oxide Atmosphere (Oslatleniye izmeneniy soderzhaniya
glikogena v pecheni, vyzvwuVkh ioniziruyushchey radiatsiyey,
pri obluchenii zhivotnykh v atmosfere a okislyu ugleroda)
PERIODICAL: Doklady Akademii nauk SSSR, 1959, Vol 126, Nr 4t PP 874-875
(USSR)
ABSTRACT; As is known, the mortality of mammals is much reduced under the
influence of the radiation mentioned in the title in a CO-con-
taining atmosphere (Refs 1-3): a) The systems affected by the
radiation regenerate earlier; b) their initial damage is much
reduced (Ref 2). In mammals, the disturbances of the carbohydrate
exchange belong to~the most distinct reactions to radiation damagm.
Particularly the glycogen content is slightly raised soon after
the action of lethal radiation doses, while afterwards it decreasw
rapidly (Refs 4-8). The mechanism of these alterations remains
unclarified. The present paper investigates the problem as to
whether CO can prevent the mentioned alterations of the glycogen
Card 1/3 content. 195 white mice were used for the experiments. One group

Relaxation of Glycogen-content Alterations in the S07/20-126-4-51/62
Liver Owing to Ionizing Radiation During the Irradiation of Animals in a
Carbon-oxide Atmosphere
of the animals was treated once with 600 r of X-iays, another
group received the same dosis in an air containihg 0-5 % by
volume of CO. A third group of mice was kept in the said CO-
atmosphere, but not exposed to rays. A 4th group served as a
control, and was not treated. Some of the mice were killed after
24, 48, 96 and 168 hours. The glycogen in their liver was
determined according to PflUger. The mortality of the 1st group
was 96.9 % within a period of 28 days, but only 24 % i~ith the CO-
protection (2.nd group). Table 1 shows that the stay of the animals
in the CO-containing atmosphere has no great influence on the
glycogen content in theliver tissue. Under the influence of
radiation, the.glycogon content rises slightly within the first
48 hours, subsequently (within 168 hours) it decreases considerably.
In animals irradiated in a CO-containing atmosphere, no increase
nor decrease in this content was observed. Thus, the CO present
at the moment of irradiation does not only raise the survival of
the mice but also prevents the alterations of the glycogen
content usual in irradiated animals. As to the mechanism of the
Card 2/3 protective action of the CO, it should ~e particularly pointed

Relaxation of Glycogen-content Alterations in the SOV/20-126-4-51/62
Liver Owing to Ionizing Radiation During the Irradiation of Animals in a Carbon-
oxide Atmosphere
out that this action is apparently not connected with a better
maintenance of the endocrine function of the suprarenal glands;
this refers particularly to the state of their medullary
substance and to the content of adrenochromes [adrenokhrom] in
it. The above explanations speak in favor of the opinion that
the alterations of the glycogen content in the liver of animals
are mainly conditioned by the damage of the liver cells. The
irradiation of the animals in a CO-containing atmosphere apparently
weakens the functional disturbances of the liver owing to the
reEulting hypoxic [gipoksicheski!61conditions. There axe
1 table and 9 references, 3 of which are Soviet.
PRESKITED: Alarch 11, 1959, by T. D. Lysenko, Academician
SUBMITTED: February 26, 1959
Card 3/3

ro
-i 11 rl Is
GRAYEUKAYA, B.M., 311-11CHL) !.A, R.N., (US P)
"Investir,ation of Disturbances "roduced in the A,,I-.-en,',LlS
by lonizing Radiations."
R~jlport prosented at tho 5th Int'l. 81.ochwilstry Conrl-ess,
Mj 10-16 At4l 1961.
1 , scom)

GRAYEVSKAYA, B.M.; SHCHEDRINA, R.N.
Nature of some structural changes in adrenal glands induced by
ionizing radiation. DokloAN SSSR 138 noo4:941-944 Je 361.
(MRA 14:5)
1. Institut, genetiki AN SSSR. Predstavlano akademikom T.D.Lysenko.
--. EFVECTI)

U908
5/872/62/000/000/003/oo6
BiU/B144
AUTHOR: Grayevskaya, B. M.
TITLE: The role of hormones of the medulla of -.he suprarenal
gland in disorders of the carbohydrato metabolism due to
the influence of ionizing radiation
SOURCE: Deystviye ibniziruyushchikh izlucheniy na organizm. Inst.
genetiki AN SSSR. Ed. by N. 1. Nuzhdin. Moscow, Izd-vo
All sssR, 1962, 157-161
TEXT: An endeavor is made to clarify the de.pe~ndence of the carbohydrate
metabolism (glycogen and blood sugar) of the irrddiated organism on the
content bf total adrenalins. Male white mice were whole-body irradiated
with 600 r or 2000 r. *in an interval t after irradiation blood sugar,
glycogen and catech.olamine-content of the suprarenal gland were determined.
Results;
Card 1/3

S/872/62/000/000/003/oo6
The role of hormones of the ... B183/B144
t 600 r 2000 r

total adre-
glycogen
sugar
I
total adre- -
glycogen
sugar

(hrs)
nalins (8,,,j ,'I
m g-,.7) (mgcf
i4) nalins (8~j)
(mg`)
P
Controls 175 2241 183 175-- 2241 183
2 130 2251 201 205' 1471 221
24 150 2131 223 110 2651 209
48 400 2501 169 - - -
72 - - - 148 1901 177
96 215 1261 150 - -
192 379 673 167
In the,,case of 2000 r the animals died before the fourth day after
irradiation. In both experimental series an increase of the total adrenEa:kl
content of the suprarenal glands is accompanied by a reduction of the
glycogen level, and vice versa. No simple relation with the fluctuations
of blood sugar level could be found. It may be assumed that the glycogen
content of the liver after irradiation depends on the adrenalin level
Card 2/3

I I S/872j6n/000/000/003/006
The role of hormones of the ... B183/B144
changed,.by the radiation effect. There are 2 figures.
-Y
Card 313

f
S/020/62/143/004/027/027
B144/B138
AUTHORS: Nushdin, N. I., Corresponding Member AS USSR, Nechayev, 1.
A., G and Shchedrina, R. N.
TITLE: Some physiologi-cal and biochemical peculiarities of mice with
different congenital radiosensitivity
PERIODICAL: Akademiya nauk SSSR. Doklady, v. 143, no. 4, 1962, 997-1000-~
TEXT: The radiosensitivity of the following three strains was studied:
cc 57-brown and BALB/c from the breeding station in Stolbovaya, CH 3 with
2 sublines from Stolbovaya near Moscow (m) and Rappolovo near Leningrad
(1); and of a mixed population (W) of mice from the breeding station at
Kryukovo. The body weight, the weights of liverg spleenv suprarenal
glands, thyroid, and testes, the catecholumine (CA) content in the
suprarenal glands and the glycogen content in the liver were determined
after whole-body irradiation with 350 -~ 650 r. The LD 50/30 was much
higher for MF and CC 57 than for CH3 and BAU/c. This was consistent with
Card 1/2

S/020/62/143/004/027/027
Some physiological and ... B144/BI38
the significant weight increase of liver and spleen found in the former
two groups, whose thyroids were equally heavier; whereas no relation
could be established between the weight of suprarenal glands or testes
and radiosensitivity. Histochemical and quantitative studies revealed
that MP had the lowest CA content. CH 3 sublines m and 1 had different CA
levels. Radiosensitivity changed in the same order. Although this
parallelism in no proof of a direct interrelation botween CA metabolism
and radiosenbitivity, it may be assumed that adrenalin is an important
mediator between radiation perception and reaction. The glycogen.level
in the liver showed the reverve order and is probably dependent on the
CA level in the suprarenal glaAda. There are 2 fig:Ures and 1 table.
SUBMITTED: JanuarY 5, 1962
Ca.-d 2/.

NY/7,
Sonse Phy,fol-sleal and f1locheadcal Peesdiarlileg of liffor "Ith Difrerlaff fffbont Radfosemill.1ty
H. Ni. GraYtTskaYn. M I. NoiMin, 1. A. Ncch2yev &M ft. -N. S(Wri"
t-veltigntlcms on the rsdiaensitivity of different stnint at animals do wt. as a rule, lnvol~ the anslysh of
physiological, metibolic or anatomic peculiarities defining the given strains. In contrast. studies or physiological
and biochemical differences between strains am generally carried out without relation to radioiensitivity.
A comparison was made of the body %-eight and -vight of liver. spleen. suprarenal glands. thymus and resticles,
and or the level or adrenal and carbohydrate metabolism. between three strains in a tt~raufl state (BA1.111c, Citt
and CC.,Br) and one population (albino) or mice charactcrited by differing radiuscissitivity as defined by the
LD 50130 dose.
0 It has been shown that raditursktant strains or mice (CC,,]3r and albino population). it comr3r?d with radio.
sensitive ones (PALD/c and C,11) ban greater we4ghts of liver. spleen and thymus, a higher content or
catecholamines In the supmrcnal glands. and a reduced glycogen level In the liver tisiuc. The 13titt phenomenon
appears to be or a secondary order and depends to a considerable extent an the intensity of the catecholamine
metabolism In the sup"remil glands.
/Jf-M At-
-T
"202't P"vente& git tbe 2nd Intl. 0009refiS of JRa&UtUn Uses"li,
xx=nmt*/r=k*b4*, ot. zrit. -v-n Aw W

4f 0 P50 -n
1617045-63 EWT(m)ffiDS AFFTC/ASD/AFWL S/205/63/00!3/002/003/024
XRjK
AUTMRSs Grayevalmya B. M._, and Shchedrina, R._N._
TITLE: The nature of X-ray effection the tissue proteim as
PERIODICALs: Radiobiologi7a,, v* 3.9 no. 2., 1963,168-173
'TEM Ths article makes an attempt.to clarify whether the rad-ioactiTation of pro-
teol,73i-3 can really be the cause'of c911 destruction in radioa.:itivity-sensitwive sys-
taw. A (mparative study has been carried out on the effect. of x-rays on the, activ-
ity of.'X?tsinases in radiation-sensitiva (spleen) and relatively moria rasistant or-
gans (livw). I The nature of the occurring changes and theLr =Lnectiozn to necrobio-
te'tia pr3csases. The wcperiments,werze conducted with white male mice 8-9 months
old weighing 22-27 go The extraot-3 from spleen and liver h=ogeneate total3y irradi-
atel in the doze of 600 r show increased fermenbative activity (on splitt Iing:casein)
vU,.,h rean_he,.,.mmdxua in spleen after 24 hours and in liver 4 days after. irradiationo
The Lnzlicatei increase in proteolytic processes was observed only aft-sr general ir-
radiation of the animal. -It is absent during local irradiation of the spleen or in
the caseaf its screening and irradiation of the remaining parts of the body, Thus
in the development of this 1process, distant effects play a significant rdlee Radia-,
tion inzreaose of proteolytic processes I-s not related directly t:) mass dest-r-z-vation.
Card.2/2-

GRO A 717 AP, !.1 , P.N.
I ~ I . - .- -- ~j - ,
~ ~:,I, v_r*jy !,ri O-e. adr-in I
ff (tc. 9
E ?. I., 4T, 'i n t I I I , " ri C, ftll(, e I
I /-~,l Tt, 1(-)
Inn"J"i"In uol 1", 1, r 'I e" vii oni o -11 zi E ).,0 ". ,
, () ~ llo, , . P, I i - I ( lril P,,, A.-!)

L 8238-66
F ACC NR: AT'
EVrr (m)
SOURCE CODE; UR
5/000/032/oo94/olA
AUTHOR: Grayevskaya, B. M.
ORG: Institute of Geneticsi AcadeaW of Sciences SSSR (Institut genetiki, Akademiya
nauk SSSRT
TITLE: Some features of protein metabolism distrubances in the animal organism under
the influence of ionizing radiation
SOURCE: AN SSSR. Institut genetiki. Trudy, no. 32, 1965. Deystviye ioniziruyush-
chikh izlucheniy na rastitellnyy i zhivotnyy organizny (Effect of ionizing radiation
on plant,and'animal organism), 94-1:L8
.TOPIC TAGS: animal physiology, biologic metabolism, radiation biologic effect,
mouse, protein metabolism, radiosensitivity
ABSTRACT: Whole-body irradiation of mice with 600 rad of x-rays increases the ac-
tivity of proteases isolated from the spleIen and liver 24 hr and 96 hr after irradi-
ation, respectively. Proteinase activity.is gauged by the ability of extracts from
these tissues to break down casein. No increase in proteolytic activity was observed
in extracts from the spleen irradiated locally, shielded during total irradiation,
and irradiated outside the body. . The dose used did not cause noticeable changes in
the substrate on which proteinases act. No difference was noted in the ability of
trypsin to hydrolyze proteins extracted from tissues of an intact animal or from ir-
Card 1/3

L 8238-66
ACC NR. W9
radiated tissue. No direct connection was found between the intensification of pro-
teolysis and necrobiotic changes in the spleen due to irradiation. AET and ICA (mono-
ethanolamine) lessen the radiation-caused increase in the activity of tissue protein-
ases, while carbon monoxide is ineffective in this respect. Experimental results
showed that the activity of tissue proteinases in intact animals of different species
and strains has a correlation with their radiosensitivity. The radiosensitivity of
the experi Imental animals decreased as the activity of proteinases isolated from their
tinauea diminiolied (nee.Table 1). OrIg. art. Mal 7 riguren and 12 t0lefi. (is)
Table 1. Hadiosensitivity of 'animals of various species and strains and the'
caseolytic activity of Drbteinases isolated from their spleens and livers
Species or strain Coefficient of proteinase activity
after 240 min of incubation
LD
50/30
Spleen Liver
Hamsters 1.22 0.95 531
Rats 1.09 1.23 6oo
Mice
Strain 1 1.26 1.16 563
Strain 2 1.59 1.37 536
Strain 3 1.42 1.49 442
Guinea pigs 11-93 1.70 400
L,;Lard

m r

ACC NRt AT4024246 SOURCE CODE: U11/2670/65/000/032/0119/0J35,
AUTHOR: Nuzlidin, N. I* _(Corresponding member AN SSSR); GralMhM,~D-W
ORG: Institute of Genetics, Academy of ScienS!fLSSSR (Institut genetiki, Akademiya
nauk SSSR) I I
TITLE: The biochemical characteristics -and radios e nsitivity of different strains
and species of mammals
SOURCE: AN SSSR. Institut genetiki. Trudy, no. 32, 1965. Deystviye ioniziruy-
ushchikh izlucheniy na rastitellnyy i zhivotnyy organizmy (Effect of ionizing radl-
ation on plant. and,animal organisms), 319-135
TOPIC TAGS: animal physiology, radiation biologic effect, radios ensi tivity,
biologic metabolism, rat, mouee, rabbit, guinea pig, hamster
ABSTRACT: Experiments were conducted with different species of mammals and
different strains of the sarde species to compare their radiosensitivity and metabolic-
characteristics. Male rabbits' golden hamsters guinea pigs, rats, and mice (4
different strains) aged 2-2. 5 months were used. After x-ray irradiation with dose
power of 47-52 rad/min, the LD50/30 of e.ach experimental animal was determined,
and they were arranged in order of increasing radlosensitivity as follows: rabbitB
Card 1/2 __UDC! 577-391

L 5137-66
ACC NRt AT5024246
(750-830 rad); rats (600 rad); mice, Kryukowskaya strain (563 rad); mice, CCr,,Br
strain (536 rad); golden hamsters (531 rad); mice, BALB/c strain (442 rad); ana
guinea pigs (400 rad). Ex"periments showed a higher level of catechol amines in
the adrenals of more radioresistant species and strains. (This difference was
more evident in individual species.) More radioresistant strains of mice also have
a lower glycogen content in liver tissue and a lower blood-sugar levelthan do less
radioresistant strains. Furthermore, there is a . distinct difference in the charac-
ter of blood-sugar changes when adrenaline hydrochloride is administered. In more
radioresistant mice, the blood-sugar level increase is lesa marked upon introductiGi L
of adrenaline hydrochloride. Irradiation of radioresistant mice intensifies changes
in the blood-sugar in response to adrenaline, whereas inradio.eonsitive mice irra-
diation first depresses this reaction and then intensifies it. In the spleen and liver
of more radioresistant strains and species, proteolytic processes proceed more
slowly. The ability of proteinases isolated from these organs to break down
casein diminishes gradually with increased. natural radioresistance of animals. The
reasons for the correlations observed are discussed, together with the possibiUty
of using these biochemical differences to assess the relative radlosensidvity Cf-
MS
Cftrig~ art. bas: 4 V4=vs a=ed 10 tj~ LUISICT;
MI
SUBM DAM: nono-1. ORIG 11UP, '0101 OTH REPI QOY

L 8234-66
MIT
ACC NRt AT5024254 SOURCE CODEt
AUTHORs Grayevskaya, B. H.
ORGt Institute of Genetic a Academy of Sciences SSSR (Institut gette-
tiki,
TITLE: Thal influence of estrogens on adrenal catechol &mine metabolism
under normal conditions and after exposure to ionizingradiation,
SOURCE*vAN SSSR. Institut genatiki. Trudy, no. 32, 1965. Deystviya
loniziruyushchikh izlucheniy na rastitel'nyy I zhivotnyy organizmy
I-(Effect.of ionizing radiation on plant and animal organisms). 223-228
TOPIC -TAGS I-radiation biologic effectl, animal physiology, biologic
tetabollam.-adrenal gland,, diethylstilbestrol, catechol amines mouse
A.BSTRACTZ- Experiments were conducted to determine the influence of
diethylatLIbestrol on the level of catechol amines in the adrenal
glands and on changes In this level under the influence of general
x-ray irradiation, Male site 2--2,5 months oldt of the radio#easitive
BALB/c strain,.were used.- Animal&-with and without an injection of
diethylstilbastrol (0#2 mg in 0,2 ml of olive oil) were subjected to,'
x-ray irradiation in a dose of 600 , rad with dose power of 30--35 radh"
Animals were killed 29 49 7, and 14 days after irradiation. It was

L 8234-66
ACC NRt AT5024254
Iig. 1. Change'in the general catec~ol
f
1'1~~mine level in the adrenals 7of mice o
xU
BALB/c strain irradiated with a,dose of
600 rad with and without ra-
W'! the adainist
tion of diethylatilbestrol.
44
o- 1 - total-body irradiation; 2 with
------------ J,
!M' administration of diethylsiilbestroi;
i'W 0 3 - total-body irradiation with adminis-.
'erati. " - of diethylst4lbestrol
on
------------
4 7
Time-after irradiation, days
found that the Introduction of diothylatilbastrol causes a prolonged
decrease in the content.of,catechat aninee to the-adrenal glands, which
may Ladicato Choir ejectLon from the adrenal# O'r the depression of their

L MA-66
ACC NAt AT5024254
synthesis. When the chemical is introduced 10 days prior to irradia-
tion, it has a radioprotective effe-ct, L.e** it prevents any increase
in the content of catechol &mines in the glands ws was observad 4-7
days after irradiation in mice not-protected with the hormon.e (see
Fig. 1.). [is)
SUBM DATE: nonet ORIG REPS 007/ OTH REF: 006
SUB CODE:
6 e,/)
Card 3 13

8236-6 MYr (m) D IA0
~CC NRt AT5024256 SOURCE CODE: UR/2670/65/O00/O32/O2A/Oi43
AUTHOR: Grayevskaya, B. M.; Shchedrina, R. N.
ORG: Institute-of Genetics, Academy of Sciences SSSR (Institut genetiki, Akademiya
99RR
TITLE: The functional state of the adrenal cortex under the influence of ioniziniz-
radiation
SOURCE: AN SSSR. Institut genetiki. Trudv..::no. 32, 1965, Deystviye ioniziruyushdhi)d
izlucheniy na raotitelinyy i zhivotnyy organ'izmy (Effect of ionizing radiation on
plant and animal organisms), 238-243
TOPIC TAGS: radiation biologic effect, mouse, adrenal gland, adrenal cortex, lipid
A13STRACT: Experiments were conducted to determine the effect of irradiation in lethal
and superlethal doses on the activity of the adrenal cortex in different periods after
irradiation. Male white mice 8 -*10 weeks old were subjected to x-ray irradiation in
doses of 600 and 2000 rad with dose power of 30-35 rad/min. With irradiation of
600 rad, mice were 'killed after 2 hr and-1, 2, 4, 8, and 30 days, and with a dose of
2000 rad. after 2. 24, and 72 hr. Experimental results showed that irradiation in a
dose of 600 rad causes an increase in the weight and dimensions of the adrenal glands,
accompanied by a gradual accumulation of lipids in the cortex (especially in the glo-
merular zone). Thirty days 9fter irradiation, complete normalization of these changes~

L 8236-66
f-AC&'NR: AT5024256
was not yet observed. Irradiation with 2000 rad, however, caused a decrease.in the
weight and dimensions of.,the adrenals,-whicb is accompanied by a sharp Increase In
the lipid content in all three cortical zones. The observed changes in the weight
and dimension's of the adrenal glands with a dose of 6oO rad are probably connected
with accumulation of lipids and excess water in the gland, whereas with a dose of
2000 rad, changes are probably associated with severe depletion of the cortical Bus-
stance, Orig. art. has: 4 figures.
SUB CODE: 061' SUBM*DATE: none./ ORIG REF: 012/ OTH REP: 0201
C 6d 2/2

GRAYEVSKAYA, B.M.; SHCHEDRINA, R.N.
Effect of estrogens on catechol amine metabolism in the adrenal
glands under normal conditions and following ionizing radiation.
Trudy Inst. gen. no.32.-223-228 165.
Functional state of the adrenal cortex following ionizing
irradiation. Ibid.:238-243 (MIRA 18:10)

AUTHOR: Grayevskaya, Engineer SOV-28-56-4-61135
TITLE: New Types of Synthetic Rubber (1~;ovyye tipy sinteticheskogo
kauchuka)
PERIODICAL: Standartizatsiya, 1958, Nr 4, pp 23 - 25 (USSR)
ABSTRACT: Information is presented on rubber production in the Soviet
Union, including the following t.-,pes: isoprene for tires,
chloroprene for conveyer belts, butyl for tubeless tires
and special rubber types. These include: butadiene-ni-
trile ("SKNII), pol.1-isobutylene, butadiene-styrol, buta-
diene -me thyl-s tyro-. (SKKS-10, , SKYS-50, thicoles and a new
type of special chlor~j,)rene rubber (9iairit-liT"). Together
with an increase in the production of the existing types the
production of new special rubber types is planned. They in-
clude: brombutyl; butadiene-methyl-vinyl-pyridine; butyl-
acrilate; poly-ether-urethan; copolymer chloroprene rubbers,
etc. The most used types have to be standardized, as well
Card 1/2 as test methods and methods of determining their special

New Types of Synthetic Rubber _',011-28-58-4-6/35
properties. Standardization of synthetic rubber will form
a part of the State Stadardization Plan for 1959-1965.
ASSOCIATIOV: Gosudarstvennyy komitet Soveta 114inistrov SSSR po khimii
(State Committee for Chemistry of the USSR Council of
Vinisters)
1. Synthetic rubber--Production 2. Synthetic rubber--Standards
Card 2/2

AUTHOR: Grayevskaya, 1. 1-1, SOV/138-59-2-21/24
TITLE: ----All-Union Conference on Synthetic Rubber
(Vaesoyuznoye soveshchaniye Po sinteticheakomu
kauchuku)
PERIODICAL: Kauchuk i rezina,, 1959, Nr 2, p 59 (USSR)
ABSTRACT: This meeting was held from December 15 to 18, 1958 in
Voronezh at which representatives of synthetic rubber
factories, research organisations, Sovnarkhozes
(Council of National Economy), Goskhimkomitet,
Gosplan USSR and TsK Trade Unions were present. The
Conference heard the following reports: Chief Engineer
for the Synthetic Rubber industry and Petroleum Chemistry
of the Goskhimkomietet M. D. Gordin on "Tasks of the
Synthetic Rubber Industry as Laid'Down by the Party -
Congress and Development ~f the National Economy or the
USSR planned for 1959-1965"; the Deputy Chairman of the
NTIIS.K and Corresponding' MaWaar of the Academy of Sciences of the USSR
B. A. Dolgoplosk, on "Investigations on the Synthesis of
New Types of Rubber and Theoretical Aspects on the
Synthesis of Rubbers with Specific Properties"; the
Head of the Laboratory of VNIISK, I. I. Radchenko,
Card 1/2 Candidate of Chemical Sciences, on "Comparative Analysis

All-Union Conference on Synthetic Rubber SOV/138-59-2-21/24
of the Quality of Industrial Butadiene-Styrene and
Butadiene-Methyl Styrene Rubbers and Ways of Further
Imppoving Their Properties"; Chief Engineer of Giprokauchuk,
B. S. Korotkevich, on "Plant Requirements During the
Ma~nufacture of Synthetic Rubber". Further reports dealt
with contact catalytic processes, the separation and
purification of monomers, the polymerisation and
separation of rubber, the mechanisation of processes
and retread-mechanisation processes. Technical personnel
as well as specialists of the VNIISK, NIISS, Giprokauchuk
and the Institut monomerov (Institute for Monomers)
discussed topics in research work; these included a report
by N. F. Nesterova, on "Improvements in the No.4 Workshop
of the Yaroslavl' Factory", by K. V. Kuznetsova--, and
V. Ya. Mymrikov.
Card 2/2

5(11) 15(9) SC-7/64-59-3-1/241
LUTHORt Grayevskaya, I. M.
TITLE; -industrial Tasks
_&garding Synthetic Rubber, in the Years
1959 - 1965 (Zadachi promyshlennosti sinteticheskogo kauchuka
v 1959-1965 gg-)
PERIODICALs Khimicheskaya prcmyshlennost 1959, Nr 3, PP 1 -5 (USSR)
ABSTRACT: An increase in the production of synthetic rubber (SR) to
3.4 times of the present output has been provided for the
new Seven-year Plan in the USSR. New types of rubber are
planned to be produced, and the quality of the existing types
is to be improved. For 1965 the durability of rubber tires is
planned to be 1#5 times that of 1958. Therefore the large-
scale.production of poly-isoprene rubber (SRI) is started among
other things, and the production of sodium butadiene rubber
(SRB) will be increased. A considerable improvement of the
quality of emulsion rubber is expected, due to the suggestion
011 the working group of VNIISK (B. A. Dolgoplosk, V. N. Heykh
et al) for the production of ternary copolymers of divinyl,
methyl styrene with small amounts of methacrylic acid (products
Card 1/4 called "carboxylate" rubber). The industrial production of

Industrial Tasks Regarding Synthetic Rubber, in the SOV/64-59-3-1/24
Years 1959-1965
(SRI) shall be carried out according to A. k. Korotkov et al'B
method. The production of a new type of chloroprene rubber -
nairit NT - is planned to replace natural gutta-percha for
glues. The production of heat-resisting types of rubber and
of poly-siloxane rubber (SRT) is also planned to be increased.
The production capacity of (SR) based on rawmaterials of food
industry, is planned to be adapted to the utilization of waste
gases of the petroleum industry, and the capacity of producing
rubber of synthetic alcohol is planned to be doubled until 1965,
and the production of rubber of sulfite alcohol and hydrolysis
alcohol is planned to be 1~5 times as high, on the other hand
it is planned to eBtablishza large-scale prodaction of divinyl
according to the method of n-butane dehydration. The Gosudarst-
vennyy komitet po khimii (State Committee for Chemistry) has
to take the necessary measures for a timely supply with the
necessary papers for planning the various projects. The amount
of the projecting material is said to be three times as high
in 1959 as it was in 1957, and the projection of new objects
for the (,SR ) production is said to be doubled in 1959 compared
Card 2/4 to 1958. The subject plans of the tsentrallnyye nauchno-issle-

Industrial Tasks Regarding Synthetic Rubber, in the SC)II/64-59-3-1/24
Years 1959-1965
dovatellskiye laboratorii zavodov SK (TsNIL)(Central Scientific
Research Laboratory of the works for (SR)(TsNIL)) are planned
to be worked out in co-operation with the State Committee for
Chemistry. The Vsesoyuznyy nauchno-issledovateliskiy institut
sinteticheskogo kauchuka (VNIISK) (All-Union Scientific Research
Institute for Synthetic Rubber (VNIISK)) which opened new branch
establishments in Voronezh and Yerevan; the-Nauchno-issledova-
tellskiy inatitut monomerov, dlya SK (Scientific Research In-
stitute for Monomers, for SR)t established in Yaroslavl', a
number of institutes of the AS and others. As the experiment of
the Voronezhskiy zavod SK (Voronezh Works for SR) in developing
a method for producing soft rubber and colophonium gum showed
that it is appropriate to carry out preliminary experiments
in the existing works, before a new production is started. In
order to guarantee that the projected plans are carried out,
the number of staff of the Voronezh and Novokuybyshevsk branch
establishments of the Giprokauchuk was increased, and new branch
establishments were founded in Ufa and Kazan'. Suggestions
regarding the reconstruction of the SR production, made by the
Card 3/4 works in Voronezh and Sumgait are of special interest. The

Industrial Tasks Regarding Synthetic Rubber, in the SOV/64-59-3-1/24
-Years'1959-1965
obligations of the Kuybyshevgidrostroy Collective and of the
young constructors and mechanics in Azerbaydzhan are also worth
mentioning. It happened that in some of the Sovnarkhozes(for
instance Krasnoyarsk) the funds provided for the- reconatruction
were used for other purposes. The competent So-inarkhozy, the
areas of which are meant to serve for experiments or research
work of competent organisations, should support these organisa-
tions, but at present, this is not the case (for instance the
Yaroslavl' Sovnarkhoz).
Card 4/4

ORAYEVSKAYA, N. A.
IlDifferential Serodiagnosis of Epidemic and
Rat Typhus."
Thesis for degree for Cand.
Medical Sci., Sub. 16 Nov. 50, AcadASci USSR
Summary 71, 4 Sep 52, Dissertations Presented
for Degrees in Science and EnRineerin-a In Moscow
in 1950. From Vechernyaya Moskvil, Jan-Dec 1950.

AGOL, V.I.; GRAYEVSKAYAj N.A.
Mechanism of the action of antiserums on the Metabolism Of t=l0r
coUs. Dokl. AN SSSR 136 no.2:479-.4& 161; (KM 14: 1)
1. Institut p0 isucheniya poliomiyelita Akademii meclitaly-kikb nauk
SSSR. Predstayleno akademikom V.A. Engellgardtom.
(SERUM THERAPr) (CAN CER ) (METABOLISM)

- GRAYEVSKAYA, N.A.; ROMANOVA, L.N.; BLLYAYEV., A.L.
Comparative study of methods for producing type-specific and poly-
valent diagnostic poliomyelitis sera. Vop. virus. 6 no 5:620-623
S-0 161. (IMU' 15: 1)
1. Institut poliomiyolita i virusnykh entsefalitov AIM SSS11, Moskva.
(POLIOMULMS imunol.)

organs or;
,Kt3r
the 3111.1.
lciol. i I rL ru"I
1. 'irS td W 1, T)n I i0flAyell i ta i Vi rusny'K; en t c,~%, i il r. - -~~,yo
.2f -n

ORAYEVSKAYA, N. D.
"The Question of the Effect of Sports on the Heart (Eyperimental Investiga-
tipns)." Sub 16 Oct 51, Central Inst for the Advanced Training of Physicians.
Dissertations presanted for science and engineering degrees in Moscow
during 1951.
SO: Sum. No. 480, 9 May 55.

ILITITNOY, 6.P. ".' LLYN'VS1QtYA, II.D.
'. I -
StluL.,,in4 the peculiarities of the higplipr nervona activity of
athletea. Probl.vrach.kontr. no.3:58-86 '55. (I-INA 12:9)
(jaia~&,ns) (I'muous Swam) (CUNDITIUM&D Ilb-SPOITSE)

GRATAVSKUtYk, N.D.
Significance of anamnesis for determining the function and
typological peculiarities of the higher nervous activity of
athletes. Probi.vrach.kontr. no.3:87-100 '55- (MIRA, 12:9)
(ATIWYES) (MVOUS SYSTEII)

LWUNOVO S.P.. krandidat moditsinakikh muk, dotoont-. GRAYIIVSKAYA, N,Doo
kandidat meditsinskikh nauk wIlOwlt-
Kethod-of irventigating higher nervous activity in athletes. Teor.
i Prak.fizk 11. 18 no-5:353-365 155. (NLRA 8:7)
1. TSentrallnyy nauchno-inaledovatellskiy institut fizichaskoy
kulitury.
(ATHLETICS. physiology,
higher nervous funct.
(CM"RA,L IMVOTJS SYSTW4.
higher nervous funct.
(MW=, CONDITIOVID,
higher nervous funat.
tests. technics)
physiolo&-j.
test in athletes. technics)
tests in athletes. technics)

GRAYNVSKAYAO 11 D - SH&M.NVA, H.G.
..=A~
~ I I "N
Problem of the distribution of training 1w4s for soccer players
during intervals between ganes based on inedical examiwtions.
Probl.vrach.kontr. no.4:5-17 '58. (MIA 12:9)
(SOCCMI-HYGIENIC ASPECTS)

MUYM,VSIUCD-,, II.D. ; SHiGTYEVA, M.G.
Change in the adaptability of the body to high-speed exercises
in soccer with relation to varying training methods. Probl.
vrach.kontr. no.4:18-37 '58. (IMA 12-9)
(znliciss) (SOCUR-MIAMIC Ab*B,,',CTS)

,Q4~~YAN.~D. -_ MATOV9 V.V.; GONCHLROVA, G.A.
Comparative data on the adaptability of athletes' bodies to various
high-speed exereJoes. Probl. vrach kontr. no-5:176- 89 60.
I,= 14:3)
(EXERCISE)

GRAYEVSKLYAV N.D.; SHAFEWAp M.G.[d6ceasedj
Dynamics of training and indications of athletic
by data--froK medical observations over a period
vrach kontr. no.5:22-43 160o
.- (RUGIM FOOTUU)
form as revealed
of years. Probl.
1 (MIRA 1413)
I
i
J

I., GRAYEVSKkYA,,--N.D,
Change in the roentgenogram of the heart following physical exertion
in athletes vith varying conditions of the cardiovascular system.
Frobl. vrach kontr. no.5:344-362 160. (MIRA 14:3)
(HURT-RkDIOGRAPHr) (EIFMISE)
j

ISTUNCV, Serafim Petrovich, prof.; MMLYANSKLYA, Rakhill Yefimovna;
GRAYEVSUYA Nina Danilovna; VELIKOVSKAYA.. P.A.,, red.;
(Methods for the observation of athletes in connection with
the training of doctors; a textbook for doctors] Ketodika,
vrachobno-pedagogicbeskikh nabliudenii za sportemenami;
posobie dlia vrachei. Pod obahchei red. S.P.Letunava. Kaskvap
Izd-vo "Fizkulltura i sportp* 1962. 399 P. (MIRA 15:5)
(SPMTS MEDICINE)

LETUNOV, S.P., prof., otv. red.; GRAYEVSKAYA _V,)D,,., red.; DEPM,
A.G., red.; SOKOWV, A.1-,-_reZ_.',--'bUNKIN, N.A., spet.3. red.
BERZIN, A.A., red.; DOTSENKC, A.A-, tekhn.red.
(Medical observations on sportsmen in the process of train-
ing] Vrachebnye nabliudeniia za sportsmenami. v protsesse
trenirovki. Red. koll. S.P.Letunov i dr. Moskva, Izd-vo
"Fizkulltura i sport," 1963. 303 P. (MIRA 16:10)
(SPORTS MEDICINE)

137-58-6-11883
Translation from- Referativnyy zhurnal, Metalturgiya, 1958, Nr 6, p 100 (USSR)
AUTHOR: Grayevskaya, O.N.
TITLE: Production and Cnunpti-., of Copper in the Capitalist
Countries in 1955-56 (Proizvodstvo i potrebleniye medi v
kapitalisticheskikh stranakh v 1955-1956 gg.)
PERIODICAL: Byul. Tsentr. in-t inform. M-va tsvetn. metallurgii SSSR,
1957, Nr 4, pp 27-32
ABSTRACT: The maximum Cu output attained in the capitalist countries
during the war (Z, 536, 300 t) (measured in ore) was attained in
1943. In the postwar year of 1946 Cu production dropped to
1, 671, 900 t; in 1950 it rose to 2, 227, 800 t, and only in 1955 did
it exceed the wartime maximum, reaching 2, 672, 700. Of this
total, 8416 was obtained in 5 countries,- the US, Canada, Chile,
the Belgian Congo, and Northern Rhodesia. The volume of pro-
duction in other capitalist countries, year by year, is also in-
dicated. Data are also presented on the production of crude
primary and refined Cu in the major capitalist countries, year
by year, and the scale of production of secondary Cu in the USA,
Card 1/2 England, the German Federal Republic, and Japan for

137-58-40-11883
Production and Consumption (cont.)
1953-1955 is indicated. Since 1950, with the onset of the war in Korea, a
deficit of Cu has been noted in the capitalist countries. The great monopo-
lies did not wish to risk the investment of capital in the copper industry,
since they had no confidence in a long-term market for Cu. As a conse-
quence, the government of the USA extended heavy subsidies to the copper
monopolies, granted them major tax benefits, guaranteed the prices, etc.,
with the result that major construction was undertaken, and as many as 20
new mines with a total annual capacity of over 450, 000 of Cu in the ore were
opened. In addition, copper smelters were built at San Manuel, White Pine,
and Hayden in the U.S.A., the Gasp6 plant in Canada, a metallurgical plant
at Chuquicamata (Chile) and in other countries. The total annual consump-
tion in the individual capitalist countries for 1950-1c)55 is presented, as is
the structure of the consumption in the USA.
A.P.
1. Copper--Production 2. Copper--Consumption 3. Industrial plants--Development
Card 2/2

137-58-5-9237
Translation from: Referativnyy zhurnal, Metallurgiya, 1958, Nr 5, p 67 (USSR)
A UTHOR: Grayevskaya, O.N.
TITLE: Production of Primary Nonferrous Metals in the Capitalistic
World During 1955 and 1956 (Proizvodstvo pervichnykh tsvet-
nykh metallov v kapitalisticheskikh stranakh v 1955 i 1956 gg.
PERIODICAL: Byul. tsvetn. metallurgii, 1957, Nr 9, pp 34-36
ABSTRACT: The author presents statistical data on the production of pri-
mary nonferrous metals, Cu, Pb, Zn, Sn, Ni, At, Mg, and Ti,
in capitalistic countries during 1955 and 1956. Production of raw
Cu had increased considerably (by approximately 10116); the
greatest increases in output., occurred in Canada, Chile, and
Northern Rhodesia (13-14%'), and the U.S.A. (916). The increase
(approximately 6%) in output of refitied CU (i[ICILIding secondary
Cu as well) is primarily accounted for by Northern Rhodesia,
Canada, and the U.S.A. According to preliminary data, the pro-
duction of At in capitalistic countries has increased by 8%. The
output of At increased in the U.S.A. (by 100, 000 tons), as well
as in Canada, the German Federal Republic, Norway, and other
countries. In 1956 a new Australian plant produced approximately
Card 1/1 10, 000 tons of Al. 1. Metals--Production G.S.
- . . - -I -I ---A _4 j __ "P P- - ~ J. .- - - -

137-1958-3-4894
Translation from: Referativnyy zhurnal, Metallurgilya, 1958, Nr 3, p 63 (USSR)
AUTHOR: Grayevskaya, 0. N.
TITLE: Titanium Plants in the USA, England, and Japan (According to
Data for IV. 1. 1957 ), Production of Non-compacted Titanium
(Titanivyye zavody SShA, Angtii i Yaponii (po dannym na
1. IV 1957 g. ) Proizvodstvo nekompaktnogo titana
PERIODICAL: Byul. tsvetn. metallurgii, 1957, Nr 14, pp 38-39
ABSTRACT: Information concerning the deposits, capacities, and techno-
logy employed by plants of the USA, England, and Japan in the
manufacture of Ti sponge. Bibliography: 21 references.
B. Z.
Card 1/1

137-58-6-11876
Translation from: Referativnyy zhurnal, Metallurgiya, 1958, Nr 6, p 99 (USSR)
AUTHOR: Grayevskaya,
TITLE: The Productive Capacity of Aluminum Plants in the Capitalist
Countries and Their Growth Possibilities by 1960 or 1961
(Proizvodstvennaya moshchnost' alyuminiyevykh zavodov kapi-
talisticheskikh stran i perspektivy rosta yeye do 1960-1961 gg.)
PERIODICAL: Byul. tsvetn. metallurgii, 1957, Nr 17, pp 28-30
ABSTRACT: A presentation is made of the productive capacities of the
aluminum plants of the largest companies (Alcoa, Kaiser,
Reynolds) of the U.S. in 1957 (total 1, 611, 000 t), of Canada
(total 691, 000 t), and of other countries, and of the design
capacities for 1960-6 1 in the U.S. (2, 404, 000 t total), Canada
(1, 019, 000 t total), and other countries. The capacity of the
entire capitalist world in 1957 was 3, 096, 000 t and is planned
to be 4, 545, 000 t by 1960-61.
1. Aluminum--Economic aspects 2. Aluminum--Production A.P.
3. Industrial plants--Performance
Card I/ I

0 A .-
6 ~- i- :-- V & E' , ~P tt :A-
7~ f %'-'t X
BISOLOV. M.F.; GRLY]ffSrAT/), O.N.; KOZIOV. V.A.
Consumption of nickel, zinc, lead, and tin in the United States
(from *Yearbook of the American Bureau of Metal Statistics" 1933).
Biul. TSIIIK tevet. met. no.4.-35-36 15P. (KIU 11t5)
(United States-Nonferrone metals)

GRAYVSFATA, OeNe, referent.
Prices of nonferrous setals-In the United States (from "Naginsering
and Mining Journalm no,l, 1956, uo,06, 1957; *Mining World" no.12,
1957). Xul. TBIIN tevet. met. no.4-.37 158. (KIM 11:5)
(United States--Nonferrous metals)

GROVSKATA, O.N.
~-
Production of nonferrous metals in capitalist countries In 1957,
Blul. THIN tevete met. U0.901-36 158. (MIRA 1196)
(Nonferrous metals-Statintion)

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it, II.W.-The inhibilins actif"I 4-1 A101,1411C Acilli 0H 011
0 CImr(rdtm of twiler plate C1, Cr mvi-I Ct
: ;1 and 0.24% Q anti Cinn. 14, hy [it. 40 alill 71f,"', 11,0.
at 20, 60 and ill)' vrm studied by stirring littliAM itle'Al
plates 01 equal wt. and diltletl-imt% f(W :1 6 lift. in
with UM Without the malthl. of I " Ill mg. a, ld'.and in I
0
~1
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1
sq. "ns. of the urg. mchimt.
;W
*
that file Inhibiting actitm.4 481"lic. IW111.4vand phIhu
*a a!
I
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ariliq is about equal and twi4iderailly hpaet I IIA13 I bal If
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jw ja emrosion emsiderably, the abs. valor of the mtrusion I)v
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USS111 / Solid IS'~~tlate~~Plvlylsicsl//-Is~rlucturaI Crystallography E-4
Abs Jour : Ref Zhur - Fizika, No. 5, 1957 #11606.
Author t Grayevskaya, Ya. I., Iveronova, V.I,p Tarasova, V.P.
------------
Inst : Moscow University, USSR.
Title i Specialized SetQp for the Determination of the Intensities
of X-ray Reflections with the Aid of Geiger Counters.
Orig Pub : Kristallografiya, 1956, 1, No.4, 442 - 445.
Abstract : Description of the operation of a nimplified setup for the
measurement of the integral intensities of X-ray diffraction
reflections.. The setup is assembled out of standard in-
struments: X-ray apparatus type URS-55, PS-64 electronic
counting circuit, Geiger counters and mechanical counters.
The high voltage and the plate currents are not 'Stabilized.
'To fix the intensities of the primary X-ray beam, a Geiger
Card: 1/2

5/188/60/000/004/017/018/XX
B006/BO67
AUTHORS: Grayevskgya, Ya. I., Iveronova, V,, I., Tarasova, V. P.
--------------------I
TITLE. The Dependence of the Characteristic Temperature Determined
by X-Ray Analysis on the Tin Concentration in Solid Cu-Sn
Solutions V1
PERIODICALs Vestnik MoskovskoZo universiteta. Seriya 3, fizika,
astronomiya, 1966-9 No. 4, pp. 52 - 58
TEXT. The authors report on measurements of the characteristic
temperature 6p in Cu-Sn alloys within a wide concentration range. These
alloys were chosen because their modulus of elasticity 6E varies con-
siderably with concentration (AE/AC - 500 kg/mm 2 per at% Sn). The
characteristic temperatures were determined by X-ray analysis from the
intensity ratios of the CuK(133) line at room temperature and at -196 0C.
For these measurements the authors chose copper-tin alloys in the a-phase
with 2.35 at% tin (2 samples), 4.73 at% (2 samples), and 7.1 at% Sn
0 samples). The samples were produced from electrolytic copper and high-
, -1,

The Dependence of the Characteristic S/188/60/000/004/017/018/XX
Temperature Determined by X-Ray Analysis on B006/BO67
the Tin Concentration in Solid Cu-Sn Solutions
purity tin, and were annealed for 24 - 48 hours at about 500C. The degree
of homogeneity was determined from the distinctness of the (133-024)
doublet of X-ray powder patterns. A Geiger counter was used for the
measurements. A curved quartz crystal served as a monochromator. The
intensity of the monochromatic beam was checked by a monitor counter.,
Fig. I illustrates the concentration dependence of 0 P. With increasing
tin concentration, 9 rapidly decreases. The same holds for the quantity
2 p
MOp which is proportional to the modulus of elasticity of the binding
forces of the atoms (Fli . 2). 0 and E are connected by the relation
e - hF3 JN 1/3 E1~2 p(h - Planck's constant, k - Boltzmann
k (40 MI/3Q1/6fl/2 (CY)
constant, N - Avogadro constant, M - atomic weight, Q - density, f(a) -
function of the Poisson ratio). At low tin concentrations, also the
relation 0 - KrE may be used, which leads to Ae 1 AE 2.0-10- 2 or
ic-5) P; -7 K-CE
Card ?/A

The Dependence of the Characteristic S/188/60/000/004/017/018/XX
Temperature Determined by X-Ray Analysis on B006/BO67
the Tin Concentration in Solid Cu-Sn Solutions
1.8-10- 2 per at% Sn are obtained, whether 500 (Ref. 14) 2or 450 kg /mm2 are
assumed for AEAC per at% Sn (Ref. 15). Fig. 3 shows 0 - f(a) and Fig.4
AEAC - f(AT/AC). The root-mean-square error of the determination of El p
was,,.,l%. The authors thank . Ye. Kravchenko or his help in the measure-
ments. There are 4 figures and 15 references: 11 Soviet, 2 US, and
I German.
ASSOCIATION. Kafedra obshchey fiziki dlya fizikov (Chair of General
Physics for Physicists)
SUBMITTED: February 22, 1960
Card 3/3

GRAYEVSKAYA, Ya.l., IMONOVA, V.I.; TARASOVA. V.P.
Wfect of the concentration of tin in Cu-Sn solid solutions on the
determination of characteristic temperature by X ra7. Vest.Mosk.un.
Ser.3:Fiz.,astron. 15 no.4:52-58 160. (KIRA 13:9)
1. Kafedra obshchey fiziki d1ya fizikov Moskovskogo universiteta.
(Copper-tin alloys--Therml properties)
(Host capqLcity)

20-119-1-27/52
AUTHORSt Grayevskiyj A, I.,- Shchegoll, Sh. S., Smolyan, Z. S.
TITLEt The Physical and Chemical Investigation of Several Systems
Containing Triethyl-Aluminum and Its Derivatives (Fiziko-
-khimicheskoye iesledovaniye nekotorykh sistem, soderzha-
shchikh trietilalyuminiy i yego, proizvodnyye)
MIODICALs Doklady Akademii Nauk SSSR,1956,Vol.119,Nr l,pp-101-103(USSR)
ABSTRACT: Pure triethyl-aluminum, diethyl-aluminum-hydride, diethyl-
aluminum-bromlde and ethoxy-diethyl-aluminum were dissolved
in cyclohexane and potentiometricalWtrated by quinoline in
a cell with a silver electrode and a platinum electrode or
conductometrically in a cell with non-platinized plate-like
platinum electrodes. The titration to'ok place in a rare gas
atmosphere. The bharacter of the curves of the conducto-
metric titration of the different substances mentioned above
becomes evident from a diagram and shows the following:
Quinoline with triethyl-aluminum forms the electrically con-
ducting complex Al(C 2H ) C H N, with diethyl-aluminum-
-bromide the electricail; cQucting complex Al(C 2H ) Br.C H N,
Card 113 with diethyl-aluminum-hydride the electrically noncMuctA

20-119-1-27/52
The Physical and Chemical Investigation of Several Systems Containing Tri-
ethyl-Aluminum and Its Derivatives
complex Al(c 2H 5)2H.'C9 H7N ~nd the complex Al(C 2H5)2 H.2C2H7N
with considerable electric conductina power. Ethoxy-diethyl-
-aluminum does not form complexes with quinoline. In the course
of the investigation also the complex compound Al(C H ) Br.C 9H7N
not described as yet was eliminated. The potentiomeiric'
titration confirmed the results obtained potentiometrically,
the sudden modification of the electromotive force in the
singular points being remarkably more distinctly marked here
than the peakB of the electric conductivity. Two diagrams
show the curves of the conductometric and potentiometric
titration of a mixture of Al(C 2H5)39 Al(C2H5 )2 Br, AI(C2H5)2 R
and Al(C H ) OC H . The-course of these curves is briefr
J.5,2
explaine A Q titration of the equimolecu 'lar mixture
Al(C2R ) Cl + AlC 2H Cl 2 a conductometric investigation of
this mMure was 1m;ossible. The Iresent paper is also im-
portant from the point of view of an eventually possible
quick and reliable determination of thq active triethyl-
-aluminum for the eatimation of the rolation between catalyst
Card 2/3 and the second catalyst in the production of the polyalkanou,

20-119-1-27/52
The Physical and Chemical Investigation of Several Systems Containing Tri-
ethyl-Aluminum and Ito Derivatives
There are 4 figures and 9 references,'O of which are Soviet.
PRESENTEDs August 5p 1957, by A. V. Topchiyev, f4ember, Academy of
Sciences, USSR
SUMITTEDs August 5, 1957
Card 3/3