(UNTITLED)

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP79-00798A000300020021-0
• Release Decision: RIFPUB
• Original Classification: K
• Document Page Count: 8
• Document Creation Date: December 9, 2016
• Document Release Date: July 19, 2000
• Sequence Number: 21
• Content Type: REPORT

Approved For Release 200.8/31 : CIA-RDP79-00798A0003000200-0
To The U.S.-U.S.S.R. Joint Commission
on a~i'eritz y c -and`- `ecFin car`C-oapera ion
The U.S.-U.S.S.R. Coordinators on Scientific and Technical Co-
operation in the Field of Application of Catalysis to Life Support
Systems for Possible Use in Future Space Exploration herewith trans-
mits to the U.S.-U.S.S.R. Joint Commission the Record of their first
meeting at Moscow, June 10-20, 1973.
The Record, which is attached, lists the topics and projects
proposed for initiation of scientific and technical cooperation i,n.
this field. The Coordinators recommend that the Joint Commission
approve the proposed priority projects so that cooperative work
may begin at an early date.
Coordinator for the U.S. Part Coordinator for the Soviet
of the Program Part of the Program
(Alvin H. Weiss) (Michael Michaelovich Sakharov)
State Dept. declassification & release instructions on file
q
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 Record of the First Meet' i
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Scientific and Technical Cooperation in the Field
of Application of Catalysis to Life Support Systems for
e---Us.,2
Fa c e e r`a--
In accordance with the U.S.-U.S.S.R. Agreement on Cooperation
in the Fields of Science and Technology of May 24, 1972, and with
the decisions of the U.S.-U.S.S.R. Joint Commission on Scientific;
and Technical Cooperation at its March 19-21,1973 meeting,. the
U.S.-U.S.S.R. Coordinators in the field of Applications of Cataly-
sis to Life Support Systems for Possible Use in Future Space
Exploration held their first meeting in Moscow, June 10-20, 1973.
The plans developed for their collaboration are included in the
attached appendix.
Professor Weiss visited the Institute of Organic Chemistry
in Moscow and the Institute of Physical Chemistry in Kiev. The
majority of his time was spent at the Institute of Chemical
Physics in Moscow. Professor Weiss gave a lecture on "Kinetics,
Mechanisms, and Instabilities of the Formose Reaction" at both
the Institute of Chemical Physics and the Institute of Physical
Chemistry.
Moscow,
Coordinator for the U.S. Part
o. the Program
(Alvin H. Weiss)
Coordinator for the Soviet
Part of the Program
(Michael Michaelovich Sakharov)
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APPENDIX
Research in the USSR-US Program in Chemical Catalysis
"Application of Catalysis to Life Support Systems
for Possible Use in Future Space Exploration"
March 19, 1973
I Purpose of Collaboration:
The development of both the catalytic systems and the funda-
mental understandings that are necessary to'transform the waste products;
of outer space exploration into carbohydrates and other products.
II Problems that might be investigated in the course of five years:
1. Catalysis of the formose condensation and the Cannizzaro
reactions:
a. Establish the nature of the complex by UV and NMR studies under
reacting and non-reacting conditions. b. Establish the rate behavior
with homogeneous catalysts of the same valence (e.g., Pb(OH)2 and
C.~
Ca(OH)2) and other valences (e.g., T1OH, Sm(OH)3 and =(OH)4), and
their effects on selectivity. c. Determine the role of pH in the
reaction. d. Establish.the techniques necessary to shift the reaction
from homogeneous to heterogeneous.
2. Kinetics and mechanisms of other reactions in the-formose
a. Quantitatively measure aldose-ketose shifts and anomerization.
b. Study the effect of reaction medium (e.g., CHOH). c. Conduct
both continuous and batch reaction studies using UV and other instru-
mental analysis methods.
Study the reverse reaction using C tracer
meth ds.
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ion med..
the_.,.foxmn.%e raaa_tio_n; _,
a. Develop qualitative and quantitative analytical
techniques. b. Use fermentation and chromatographic
techniques to isolate unique branched species. c. Chemically
and physically characterize branched species and compare
them to known compounds. d. Study the hydrogenation of formose
products to polyols.
4. Biological effects of branched aldoses, ketoses, and
polyols:
a. Using species produced in 3b, conduct studies to
establish the metabolic pathways and products that are the
cause of the toxicity of formose.
5. Mathematical analyses of the reaction kinetics,
oscillations, and instabilities.
6. Conduct investigations of the other problems that
may arise and become important in the course of the research.
III First Year Activities and Participants
1. Development of methods for analyzing complex car-
bohydrate mixtures (Institute of Physical Chemistry of the
Ukrainian SSR Academy of Sciences [IPC, AN UkSSR] --
corresponding member of the UkSSR, Ya. B. Gorokhovatsky;
Worcester Polytechnic Institute -- Prof. A. Weiss).
2. Use of UV and NMR spectroscopy to study the nature
2+
of formaldehyde and carbohydrate complexes with Ca ions,
active in reactions of aldol condensation in alkali environment
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(Institute of Chemical Physics [ICP], AS USSR -- Prof.
O .V- Krylov; Candikte of
Sakharov), and preparatory work on the use of these methods
to study the nature of complexes formed with the participation
2+
of cations of Pb and rare earth elements (ICP, AS USSR --
Prof. 0. V. Krylov; c.c.s. M.M. Sakharov; IPC AU UkSSR --
corr. member Ya. B. Gorokhovatsky).
3. Use of radioactive tracers to study the role of
reactions of retroaldol fission in the process of condensation
of formaldehyde into carbohydrates (ICP, AS USSR -- Prof. 0. V.
Krylov; c.c.s. M. M. Sakharov).
4. Continuing analysis and reaction studies as well as
a study of the possibility of transferring from the use of
a homogenous catalyst to a heterogenous one in the synthesis
of carbohydrates from formaldehyde (Worcester Polythchnic
Institute -- Prof. A. Weiss).
5. Use of fermentation. and hydrogenation to separate
complex mixtures of carbohydrates and obtain individual
carbohydrates and polyols (Worcester Polytechnic Institute --
Prof. A. Weiss).
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mhe foliowing invitations to participate in the joint
problems will be submitted:
a. From Dr. Sakharov to a scientist of the Moscow
Institute of Medical-Biological Problems, b. From Dr. Weiss
to Dr. J. A. Shapira of the NASA Ames Research Center.
Each will be requested to submit proposals that are in accord
with their own research interests, with the goals and policies
of the US-USSR Program in Chemical Catalysis, and which, of
course, have the approval of their own institutions.
IV Possible Forms of Collaboration
1. Direct personal exchange of data, preprints, reprints,
chemicals, and equipment.
2. Conduct experimentation on an equal man-month basis
in each other's laboratories.
3. Write papers jointly and assist each other with
translation.
4. Arrange scientific visits and tours for senior
scientists.
V Possible Initial Visits
Unless there are particular reasons, Drs. Weiss and Sakharov
(or other scientists of the same rank in this area of research)
will meet at least once per year in the USSR and USA, alternately.
Visits of senior personnel to the US and USSR should be for
approximately equal total time periods extending to as
much as one and one-half man-months in the host country
annually.
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USSR collaborative activities on toxicological and other
 . 4 rl + .
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Visits of junior researchers will most probably commence
`-" n t .e"seconCT HiL f "`0 74` excl ucTing ' ii7`y arid- ugi s iri "t he
USSR). It is expected that 1 or 2 US and USSR researchers
will spend approximately three man-months in the alternative
host countries annually.
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Amended version of the record of the
first meeting of US-USSR project
coordinators in the field of application
of catalysis to life support systems.
(Cop
of
li
y
ear
er record forwarded you
August 1, 1973).
FROM: (Name and Org. Symbol)
ROOM NO. & BLDG.
PHONE NO.
22639