FINAL SUMMARY REPORTS WITH ATTACHED REPORTS TITLED FINAL SUMMARY REPORT OF K TABLET AND FINAL SUMMARY REPORT OF T.D. DATED 09/05/1945 & 09/06/1945, RESPECTIVELY

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00144767
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 4
• Document Creation Date: November 22, 2024
• Document Release Date: January 15, 1983
• Publication Date: September 6, 1945

�
1.
6 September 1945
MLMORANDUM
TO:
Research and Development Branch
FRO:
Special Assistants Division, R&D
SUPaCT: Final-Summary Reports
1. Herewith attached are the following final summary
reports submitted from Special Assistants Division, Research and
Development Branch:
a) "K" Tablets
b) T.D.
. Special Assistants Div.
Research. and Development Branch
1..
SPECIAL ASSISTANTS DIVISION, R&D
FINAL SUMLiARY REPORT OF K TABLET
5 September 1945
INTRODUCTION
Authorization: There is ho letter of authorization in the Special
Assistants Division files but it is understood from --
former Assistants Division that such authori.ation was
6iven orally by , former Research and Develop-
ment Brinch. Special Assistants Division was to cooperate with the Medical
Branch in giving advice and doing such experimental work as was possible
within the Special Assistants Division.
Experimental work was done at
and in the laboratories of Special Assistants Division.
Purpose: A small quickly soluble pellet was desired which would cause
rapid unconsciousness ("Knock-out") of a victime but there should be no
possibility of death being caused.
MATERIALS AND EXFLRIMENTAL METHODS
The choice of suitable."knock-out" material was rather limited because
almost all drugs, if given in sufficient dosages, are fatal. The differenCe'
between the "knock-out" dose and the lethal dose depends a great deal upon
the individual subject so that a knock out dose for one person might be a
lethal dose for another. Therefore, materials had to be picked which had a
relatively large differences between "knock-out"-dosages and lethal dosages.
Chloral hydrate was one suitable material frcm this point of view.
However, from the point of view of making suitablepellets, chloral hydrate
was not satisfactory because at ordinary temperatures it is a.liquid.
Therefore, a suitable water soluble binder had to be sought.. The binder chosen
was Carbowax 4000, produced by Carbide and Carbon.Chemical Company, New York,
New York.
1
t,Tfc.)
Here again another difficulty arcse--the pelletpeeded to produce the
requirements above became a wafer.
Nevertheless, a suitable wafer contained the following proportions:
Chloral hydrate
Carbowax 4000
2.5 grams
7.5 grams
ThQ second most Suitable material from the dosage point of view out the
first choice as far as binder and size were concerned was a mixture of .morphine
,
and nyoscine with a glucose binder. These materials were to be in the
� proportion of:
Morphine tartrate 0.75 grains
Hyoscine hydrobromide 0.20 grains
and sufficient glucose syrup to bind the materials.
Experimental Methods: All physiological data wa!, obtained fro standard
pharmacological books with the comments of the Medical Branch.
� . .
In the case of the chloral hydrate wafer, the Carbowax 4000 is first
melted and the chlorAl hydrate dissolved therein. After hardening, the
mixture may be formed into a warer in a suitable pellet press.
In the case of the morphine and hyocine, a dry mixture is prepared,
noiL.'tened with the least possible amount of glucose syrup and formed into
a pill by means of a suitable pellet press.
RESULTS .
�
The chloral hydrate wafer will dissolve in two to three minutes in water or
a water-alcohol mixture. Because of its bitter taste, it is suggested that a
flavored beverage be used such as tea, coffee, whiskey or other alcoholic
drinks. The amount of chloral hydrate used is well below he ten gram lethal
amount even for the most sensitive victim. The effect would take place in
ten to fifteen minutes, reach its effect in one hour, and wear, off in five to
ten hours. During this time a man could be roused but not easily.
The morphine-hyoscine mixture will also be dispersed in the sime liquids
in about the same time and should be used in the same manner. The effect
will start in about thirty minutes and last several hours. The Rellet does.
not produce loss of sensation but reduces sensaticin and greatly diminiFhei the
power of attention and the power of memory.
The difference between' the "knock-out" dose and lethal dose in this
latter case is not as great as that of chloral hydrate. In the case of chloral
hydrate the factor of safety is about four to one, whereas in the morphine-
hyosoine mixture this factor is about two to:one.
CONCLUSIONS
Although no "IC" tablets reached the field, the correct proportions and
procedures have been investigated, so that at some future date, suitable pellets
could be produced.
RE,COUENDATIONS
Some law enforcement agencies might have a use for "K" tablets.
Special Assistants Division
Research and Development Branch
-
SPLCIAL ASbIt,TANTS DIVISION, MO
FINAL SUl.ARY KLPORT OF T. D.
6 September 1945
INNODUCTION
Authorization:, This project was initiated by a memorandum from'
Research and Development Branch to
Uedical Branch, dated 19 January 1945, entitled T. D. It
was understood that Special Assistants Division would offer any advice or
laboratory facilities desired. '
Pui-pose: The material to be used was to produce unihibited truthfulness
in an interrogated person.
MATc.RIA.LS AND EXPERINItATAL Ir,THOEC
Materials: The active material selected for the physinlogical and
cological test was marihuna acetate in a purified form. This substance
made into a 50% by weight alcohol solution.
PsY �
was
Lxperimental 'iiethods: When the solution was prepared varying amounts
were incorporated into tabacco for making cigaretts and.also were dissolved in
drinking water. The amounts involved varied from 1/100 cc to 1/400 cc of the
alcohol solution. The T.D. was administered without the victi:m being aware
of the procedure by getting him to smoke a cigarette or ,drink a glass of water.
Ri:SULT3
Reactions of the'victims to
attached copy of a letter to The
from
the subject of T.D.
�
the interrogation procedure are given in -the
Director, Room 124, Administration Building
---- dated 31 August 1945, on
CONCLUSIONS
, Indications are that uninhibited truthfulness can tot be obtained 137_
this method.
None
RECOILLLNDATIO1I3
Special Assistants Division �
Research and Development Branch