MKULTRA SUBPROJECT 91 (39 DOCUMENTS WITH PUBDATES FROM 590115 TO 640611 )

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00017494
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 67
• Document Creation Date: September 25, 2024
• Document Release Date: September 8, 1976
• Publication Date: January 15, 1959

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Advanced animal screening
preclinical pharmacological
testing.
Project 1.MICRA, Subpro
Date .Initiateds 15 Januar/ 1959
Pate Expire: 1 tebruary 1962
Funds-atuTent year; $.148,000
Purpose: To provide *A advanced. ardoal screening and predoliniced,
phaxascolog.teal testing of toxics and drugs affecting human behavior
vith special reference to drug effects-and Molecular structure relation..
ships a:xi avoidance of undesirable effects.
Status: A continuing program of ad hoc screening ard, testing utilising
protocols provided by and closely monitored by ?SD.
1
MEMORAMUM FOR : Th RECORD
SIBJECT MKULTRA Subprojects 70, 91, 94 and 135
letion of the audit of Project NOMA for the period -
January -1963,-aceoUntings have been received
In the amount of *93,67.50. s amount
ance to-be-accounted-for b
grantees at the end of the audit peri
Subproject 70 incurred direct-costs of *2,518.34 and $27,872.16
transferred from Subproject 94, fora total�of7$30,-390.50. Subproject
94 incurred expenses of $734324-.87,_bilt�transferred $4,165.71 to Subpro-
ject 91 and 27,872.16 to Subproject-(0i-leaving-a-net cost of $39,287.00.
It was decided to divert the-funds-for-Subproject 135 te-Subproject 91,
therefore these costs vere included-in.the-accounting from Subproject 91.
Inasmuch as: 1) all four:of-the subProjects had the dame basic re-
search goal in mind, 2) the great length_of_time that has eL.7:led since
the grants vere made, and 3) the difficulty in getting accountings of
any sort from the grantee, it-is-recommended th we
ter by ace ng for the balances:as:shown
count for these subprojects.
The above had been concurred in bl
Staff.
of the Audit
.
.
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cember 1,_19 1_to_july_31, 19
Grants_
February 1, 1961 to January 31, 1962 SO, 000, 00
Less, previously reported 404100.00 $3,000.00
24,000.00
$32,000.00
February 1, 1962 to July 31, 1962_
Total
Accounted for, as follows:
Salaries
Payroll Taxes
Employee Benefits
Laboratory -Supplies: and.Bxpense-- -
Travel
Other Direct Costs
Indirect Costs
Total Costs
Less, Previously reported
Total AccoUnted FOr I.
I certify that services or mhterials Imve beitft
satisfactorily received npl the e;0-11ditUra
Nir.ers ;Incurred on official huts. -
$28,131.14
1,400.08
355.68
3,541.48
50.61
2,569.17
36,372.26
72,939.42
121:02/13_61-
W-,151
9/
February 1, 1961 To November 30, 1961
Grant Income::
- -February 1, 1961 to January 31, 1962
Less, Deferred Income
Costs - February 1,_1961_To November 30, 1961
$ 48,000.00
8 000.00
40,000.00
Salaries
$ 18,570.83
Payroll Taxes and_InSurance
899.48 -
Employees' Hospitalization-and Benefits Ins.
355.68
Laboratory Supplies and Expense- --
2,532.91,
Travel
426.61.
Other Costs
2,69,71
25,354.68_.
Allocation of G and A_Expenses
10,373.97-
35,728.65
4,271.35
Transfer of Costs from Project 510
4,165.71
Excess of Income
105.64
1
ends.
closed here *th
February 20, 1963
t f
S from
nd
Herewith is a statement of the funds expended in behalf of
the project on pharmacological screening and testing. Wo-tftet-that
it will be ade4wate for youripurpoaew.
PHARMAGOLOGICAL_SCREENING AND_TESTING
FebeVary_11 1961 To January 31,_1962
Grant Income
Costs - Feb._ 1, 1961 To-Jani-l1-1962
Salaries
$ 23,1.89.27
Payroll Taxes and Insurance
1,027.36
Employees' Hospitalization and Benefit
16 .19
Laboratory Supplies and Expense
Travel
Other Costs
Allocation of G&td A &pens.
$ 48 000.00
5.
ffio
3,999.17 _
12506.12
3,847.60
4 34,2d5.Th
2212a1E2
Inva C.71=7_7:-"3 7-1
48100040_
TSSICIcal Div44
+M.
MEMORANDUM FOR: THE RECORD
SUBJECT
10 November 1961
: Correction to Project M(ULTRA, Subproject 91,
Authorization No. 5, dated 27 Time 1961.
1. The referenced subproject was extended in June for only
six months when the intention was to extend for one year in time,
but to finance the first six months only at the time of renewal.
2. In order to clear up this matter, tSubproject 91 is hereby
extended in time only for six months beginning 1 February 1962.
TSD/Ree-earth Branch:
./7
No.
Cost Account .4A60A04r� At" "Jjea
Object Class
Date
I AUG
1961
3 AV
Remarks and References
4=1.=����1�11"
Obligations Obligations Unliquidated
Incurred Liquidated � Balance
41,t41'60. Al,
40451
Undertb. authority granted in the nemoraneaus dated 13 April 1953/
to the WA and the extension of tht3 uthority la eub-
the DC
*quest cancgrandaSublaroject_21.7viks previously approved. Under the
ee authority an additional sea of 124)90.00 hni bow% authorited
to over the subprojects expenses, tote charged nainst cost center
Not 2123-141)0-X04
4-arth Branch
Date:
I CERTIFY TriAT FUN D APE AVAI!A3LE4
0Aucmic,:i_tEri:ro,.:IcrN. /144
11:11AFC3/4 10 � N.13Jr.:4/71. j pi 2-
AUTHOZ.ZING OFFICER
Dietributd
OrlairAd
TSD/R13
2 �Addressae
Vf - TSD/FASS
2 - TSD/RB
7 June 1961
VIA
4 aUsgust 1961
It: CHILY, MANGE DIVISION
TSD/Budget Officer
kilCULTRA. Subproject 91, v ce f5
Allotment 21254390�3902
Invoke 15 covering the above subproject is a
should be made as follows:
ched.
�isbIi1r's�cklth. am tot $960.00 plow* to
drawn on
?/
iy
2. e rward the checks to Chief, TSD/Research
Branch through TSDAtudget Officer by 21 August 101.
3. Mit ist a final invoice. However since it is antici-
pated that additional Auld* �vill be obligated f�t1Is project, the
files should not be closed.
Attachments:
Invoice & Certifica
Distribution:
Orig & 2 � Mdrei
ci
ranch
.4' 1
"LI
ei*c�/
-
4 Aulfult 1761
wow, rnaricz DIMON
TSD/Budget Officer
MKULTftA. Subproject 914 Invoice IFS
Allotment 2135-1390-3702
L Ceficovsrfrg the above subproject is attached
Payment should be made ass follows:
2. Please forward the checks to Chief, TSD/Research
Branch through TSD/Budget Officer by 7.1 August 1961.
3. This to a final invoke. However. Once it is antici-
pated thet add:mania funds will be obligated for this project. the
files should not he closed.
Attachments:
Invoice & Certifications
Distribution:
Orig & 2 � Addressee
TSD/FASS
TSD/RB
Chief --
T /Research Branch
I CERTIFY TriAT FUNDS ARE AVA/LABLEi
pRoc,oN Rfli N.depfkp
ci-v-.4-Qk TO
TSD/R134P4 August 1961)
AL:TdCR,ZING OFFICER
17 August 1961
Gentlemen: _
We are pleased to be able to tranaollt to yots the following
funds:
These fwzds represent a contribution for the use of your
directors in carrying out the very worthwhile research goals
of your obligationa.
Mtaclvneite (2)
Yours truly,
For Se.
INVOICE
C RTIFICATIO14S
--424i 9
!,1) It is hereby tertifted th3t this is 7.nvoice5_ apAing to
Sub-project No_AL__ YIKULTR21,, that performance i* etatittf4tWry4
that iservi,:;ts are bang accompti shed in accordance with mutual agree-
aunts, that 4 detailed agt.nda of thil pkvments-4nd rueipts is CA file
in TSD/RB,, that the bill is jt t:krd -.'orrect and that p4yrnent thareof
h-3.3 not yet been rnada.
hief, TSO/ReAearch Brantth
...�������=ok
Ditel
h is hereby certifted that this invoice applien to Subproject
a MICULTItA which was duly appre.,:r.ed, and that the, project 13 being
carried out in a.ir.'cordance with the trierm,r1ndtlyn a 13 April 1953 from
the DC! to Vic.t DD/A� And the t7'...f>t&IISkri, Of this authority in 41tbeequent
m e rn. r nd
Rel)ear4-h Dar ecte.r
CONFIDENTIAL FUNDS POSTING VOUCHER
VOUCHER NO. 7.12
DATE 2.6 !VOUCHER NO. 7.12
DESCRIPTION-AL(. OTHER ACCOUNTS
.43-33
DESCRIPTION.
ADVANCE ACCOUNTS 13.27
3
'VIA NO.
34.39
STATION
CODE
P.O. NO.
PROP. NO.
. 32.33
Oil.
PROJECT MR
40.42
EXPEND
CODE
FY
49
45.46 ORLIG.s7 54.57
PAY REF. NO. GENERAL
PER. ...ADVANCE CA LEDGER
LIO. ACCT. NO.
.. YR ACCT. NO.
CODE ...
EMP. MO.
58.671
ALLOT, OR COST
ACCT. NO.
0.70
DUE:
DATE
AMOUNT
52.67 :
CR. NO. ONJECT
CI. ASS
NIT
CREDIT
t,.
: : ..... . .44:12
........
ZZ
46/0
rirtz
075 -- /35*-0
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XPLANAT1ON OF ENTRY
TOTALS
frc'
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10.59 606 USE
"'NERVOUS (DITOO
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EVIEWED RY
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CERTIFIED FOP PAYMENT OR CREDIT
SIGNATUR
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ICER
f10.49)
KINORANDIN4 FOR: THE CORD
27 June 1961
OUEJECT : Continuation of Pojet KULTRAi-Suhproject 91
Authorization #5
1. Theprpoeeofthiu6ubrojectie to provide fundA to_continue
the research program vbich-fUtnithes advanced animal screening and
;Technical pharmacological testing required by theprogram-On the
development of new psychochemicals. The program is. providing ---
fUndamental information bearing On the problem of structure:activity
relationshipleamong_these c
2. The research-groupconducting the investigations are exerting
their testjefforts to_provide the data requiremente imposed on them. The -
experimental vork-beingTcarried outlunder this_project is oriented and _
programmed to meet our planned-research and deVelopment needi. In order-to
bring Cie. program into alignment vith contemplated researches-and possible
modifications -that maybe dictated by anticipated results from the current
research, this program vill_be extended for a six month period,
3. Theicost of this program for a period of six months beginning
1 August,1961-it estimated to be- 424,000.00. To this sum must be added
*960,00 resenting a foOrlier_cent ieryice charge t
who viii act at cut out so that the
total cost of the project vill not exceed $24:960.00. Charges should be
made against A1lotaient No, 2125-1390-3902.
-
received Zr
ha
requested that
bait to them a summary accounting of funds .
that they return any unused funds
remaining at the end of the grant period.
5. It is not anticipated that any permanent equipment vill be
required for this program.
6. It hsa been agreed that documentation and accounting for travel
expenses which are reimbursable shall conform to the accepted practices
of the organization conductingithe_researeh.
7. The-requirement for a semi-annual informal accounting on the part
of the principal investigator has been valved.
8. All personnel connectedwith_the_planning and monitoring-of this
program possesses -Agency TOP-81CRET approval� The project_villte
unclassified_after_it_leaves_the
TED/Research Branch
APPROVED PR OBLIGATION OF FUNDS:
Date:_ 3061
Attachments:
Budget and propose
Distribution:
Original only.
FROPOSAL
It is proposed to continue certain biological tests of a
pharmacological nature as directed by the Sponsor of this project
-on-chemical materials and extracts to-he furnished hy the sponsor.
These tests involve-small animal studies and/or clinical work in
certain eases as indicated in each particular instance. _Theeponsor
_ will have hill control of 0/methods and procedures to be folloued
in the work and it is understood that these will vary -during the
-course of the project-depending upon research findings in other
facilities working in this same general-biological.program.
In addition, as time and funds allow,-pilot experiments viii be
performed utilising various known substances having-effects on the-
central nervous-system in an effort to refine and improve the present
capability of detecting and Characteriting such activity in small
-animals. Attention vill-elao be given to the problem of-eXtftpolation
of results between varicAm species of animals.
-
It is expected that the attached budget viii be required to carry
out the program outlined above for a period of six months.
BUDGET
ll�ff/=~..=1/
Salaries
45,000
Overloud (25$ of Salaries)
3,750
Travel
boo
Services (Analytical,et*.)
1,400
Supplies and Materials
1,000
Animals
2,250
Total
$24,000
15 February 1961
Gentlemen:
We are pleased to be able to transmit to you the following
funds:
Mese funds represent a contribution for the use of your
directors in carrying-out the very worthwhile research goals
of your obligations.
Tours truly,
tnclosure (2)
Date
Remarks and References
Obligations
Incurred
Obligations
Liquidated
Unliquidated
Balance
"9%1
004,1644i, .11 N .MiZir '1r, 7
7
a 1951
.../eil2A._.
i
.
I
._
1
4
4
WaTRAVDUMF_ OCVROZILla
AlTaTIOD Finanno Divialon
EtEji3GT _ WEERA, Et"Spr joot_lk, A;Ithortzation
Utds_ye tho autrl,ty Grsnted in tho tn;momraa7m1ateA 13 April 1953,
isma t,z,e DOI to tho rO/A evi ti a extzw,lon of this wncrit7 in aub-
esqpz,Lt al,f_zo-?en13., 5111Qrejt 91 -nre7Scy.t1z. spyzovoa. Ulaer tha
alatIlorlW aa o:?___4111400,001.:vonwizea
to (..lav:T tTfo aivb-,:xo4oets o7,-;,-,,enss, to be 6.0,a-a ocst
110-23906,902-
10
Dotr.:
Orlz. 2,-
TSD/FASS
2 - TSDAB
-OS
!F.,fID/Reich Zsraneh
lalatAlealt CEO?, FLU= DIVISIOS
2 February 3.961
lailudget Officer
s IOW1M2A0kbproject 91, ivoi
Allotment 1125-1390-3902
le inyoice 14 co, rine tbs above subproject is attache4.
Past shouiA be axle as fo1lows:-
2. Please fOrvard the checks to Chief, TD/search Branch
threw& ISDAudget Officer-by 15-74brusey 1961, ,
3. This-Is a final invoice. Bovever-since it Is at1cipeteil
that additional fUndt-vill be obligated for this project tbe files
tbould not be closed.
Chief
TOD/Beitarch Branch
Attacbmentst &I/400:
Invoice is CertificaticaLG!..
.;
,
CONF I DENT I A L FUNDS POSTING VOUCHER
VOUCHER NO, 7.12
DATE 2.8 !VOUCHER NO. 7-12
DESCRIPTION-ALL OTHER ACCOUNTS 13.33
34.39
STATION
40.42
45'4
PAY
PER.
47.52
OOLIG.
REF. NO.
53
54.57
GENERAL
58.67
ALLOT. OR COST
ACCT. NO.
68.70
DUE
DATE
71-80
AMOUNT
i
DESCRIPTION-
ADVANCE ACCOUNTS 13�27
VA. NO.
T.O. NO.No.
CODE
EXPEND
CODE
U
N
D
Ll.
om.
CODE
:pp
.
Emp. No.
CA
YR
LEDGER
AJECTJ
CCT. NO.
62.67
CO.NO.
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4.4
SIGNATURE 0 FFICER
FORM
10.55 606 USE FACTIOUS EDITIONS.
400.411
YEMORANMUM FOR TM RECORD
SUBJECT: Project NICULTRA Subproject 91
1. The purpose of this subiroject is to provide funds to
continue the research program which furnishes advanced animal -
screening and preclinical pharmacological-testing required by the
program on the development of new psychoehemicals. The program is
providing fundamental information bearing on the problem of structure
activity relationships among these compounds.
2.__The research group conducting the investigations are exert-
ing their best efforts to provide the data requirements imposed on
them. The experimental-work being carried out under _this project is
otiented and programed to meet our planned research and development
needs. In order to bring the program into alignment with contemplated
researches and possible modififIstions that may be dictated by_anti--_
cipated results from the current research, this program will be
extended for a six month period.
3. The cost of this program for a period of six months beginning
1 February-1961 is estimated to be $24,000.00. To this sum must be
added 06 representing a four per cent service charge to the
who will act as cut out, so that
the total cost of the project will not exceed $24,960.00. Charges
should be made against Allotment Noi-1125=1390-3902.
!Th
s requested
them a summary, accounting of
d that they, return any unu ed
funds remaining at the end of the grant period. :
5. It is not anticipated that any permanent equipment viii be
required for this program.
It has been agreed that documentation and accounting for
travel expenses which7are_reimburscable shall conform to the accepted- � -
practices of the organization-conducting the research.
7. The requirement for a semi-annual informal -accounting on the ,
part of the_prineipal--inveatigatOr has been waived
-
8. All personnelconnected with the planning and monitoring of
this program possesses Agency TOP-SECRET approval.�The project-will--
be unclassified.-afterit-leaves
APPR D FOR 0 TIO OF FUNDS:
Date
Attachrents:
Budget and proposal
Distribution:
Original only.
Chief -
TSD/Reseerch Branch
PROPOSAL.
It is proposed to continue certain biological tests of a
pharmacological nature as directed by the Sponsor of this project
on chemical materials and extracts to be furnished by the Sponsor.
These tests involve small animal studies and/or clinical work in
certain cases as indicated in each particular instance The sponsor
will have full control-bf_the methods and procedures to be followed
in the work and it is understood that these vill vary during the
course of the project depending upon research findings in other
facilities working in-this same general biological program.
In addition-,-as_time and funds allow, pilot experiments will be
performed utilizing various-known substances having effects on the
central nervous system in an effort to refine and improve the present
capability of detecting and zharacterizing such activity in small
animals. Attention will-also be given to the problem of_extrapolation
of results between various-species of animals.
It is expected that the attached budget will be required to carry
out the program outlined above-for a period ef six months.
9/,-,2()
BUDGET
Salaries.. . .
$15,000
Overhead (25% of Salaries)
3,750
Travel
boo
Services (Analytical,
1,400
etc.)
Supplies and Materials
1,000 ,
2,250 .
Animals
Total
$24,000
Amount of Grant -
Expenditures
$20,000.00
Salaries and wages
t4605.50
Materials and Supplies
3943.00
Rent and Utilities
8349.22 -
Travel
- 573;30
Services
789.624
Social Sec. Ins. etc.
587.96 -
Overhead
1151.38/_
20,
20,000.00
BaLsnce
9/
15 March 1960
Gentlemen:
We are pleased to be able to transmit to youths following
funds:
urer's Check No. 248053 drawn on
, for $1,800.00
2861 drawn,
or $45.000.
These funds represent a contribution for the use of your
directors in carrying out the very worthwhile research goals
of your organisation.
Enclosures (Z)
Yours truly,
�
No.
MA"
Cost Account 1:07"," 1,1,* 4441
Object Class
Date
arks and References -
Obligations
Incurred
Obligations Unliquidated
Liquidated Balance
29 17680 A1 f8 i;
04- yk- �"-.0
',fussy 1960
0 A.NDU14 FOR: COMPT 01,1.1CR
1' ION s rINANct DIVISION
MKULTRA, iv.bpi.jsd 91, Ad41ttont
Authorleatioa Nes 3
Vader thenuthority grantod she snoseeresdum
ted
3 ApsU 1933 firma the OCI to the DD/As and the eXt0411101% Of
this authority le lehetquezt Inenneranda Subprojett 91 ha*
bete approved and $46i1100.00 Of the ovor.all MRULTRA project
flied* he* boo* obligatod to cover the eubproject ospeesea. This
shiigatiou el feeds should be ehangod to Allotoseet 0523-1009-4902.
APPROYZDrOR MAGNI 0
or ruNDS:
TSS/Cheralcal DiViriOtt
ati:TY THAT rulq3s ;1,71.e
Ottgleo.1.7.N AA,'Pol'?"
,;(7E2
-
*south (rector
�
IOW*
1 f_TSS/OC
TSS/FASB
Z. /CD
TSS/CD 11 Feb 60)
TO:
FROM:
SUBJECT:
MEMORANDUM RECEIPT
I hereby acknowledge receipt of the following:
Please reti&rn s en.. copy(l ) of this receipt
To
FORM NO 7c2 REPLACES FORM 36.44
1 AUG SS' ''' WRICH MAY 4E USED.-

TO:
FROM:
SUBJECT:
V GNAT RE OF R CI IE
NoteRttilwb
(33)
MEMORANDUM RECEIPT
I hereby acknowledge receipt of the following:
,e�c)
e
Please return signed copplies) of this receipt
To
FORM NO. 752 REPLACES FORM 34.46
1 AUG SSE WHICH MAY BE USED.
_ t/d
/DATE
ENT
/17 6L):
DATE RECEIVED
4331
MEMOS
VIA
SUSIE T
9/.2
1 March 1940
DUM F ; CHIEF, YINANCE DiVISION
TSD/Iludget Officer
kLICULTRA, Subproject 9l Invoice 13
Allotment 0525.100-4902
Invoice 13 covering the above subproject le atteched.
Payment should be made as follows:
2. Please forward the cheeks to Chief. TSD/Chennical
Branch through TSD/Budget Officer by 15 Marchi 1960.
1. Thie is a, final invoice. However. since it is anticipated
that additional funds will be obligated for this project, the files
should not be closed.
Chief
TM/Chemical Stanch
Attachme s:
Invoice & Certifications
Owl Addressee
4.4 3
4CEME0
INVOICE
for Services $46,800.00
Cm4ste.M4041, ...... 0000
CERTIFICATIONS
(1) It is hereby certified that this is Invoice f3 applying to Subproject
9101 IiIKULTRA. that performance is satisfactory, that service. are
being accomplished in accordance with mutual agreements that a
detailed agenda of the payments and receipts is tiled In TSD/CB, that
this bill Is just and correct and that payment thereof haa not yet been made.
Date:
Chief, TSD Chemical Branch
(2) It is hereby certified that this invoice appliesto Subproject 91
under MKULTRA which was duly approved and that the project is
being carried out in accordance with the rnmorandum dated
18 Apr111933 from the DCI to th-e-DD/A. and the extension of this
authority in subsequent memoranda.
Date:
Research Direct�
CONFIDENTIAL FUNDS POSTING VOUCHER
VOUCHER NO. 7.12
DATE 2.6
VOUCHER NO. 7.12;
DESCRIPTION.ALL OTHER ACCOUNTS 5.35
34.39
5yATIDN
CODE
.
PROP. NO.
40.42
ExpEND
CODE
49
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47.52
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55
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FORM cAe
10.59 VW, USE POICVIOUS COITION .
9/'97
DRAFT
11 February 1960
MEMORANDUM FOR: THE RECORD
SUBJECT : Project MKULTRA, _Subproject 91
. The purpose of this subproject is to provide funds to continue
the research program which furnishes advanced animal screening and
preclinical pharmacological testing required by the program on the develop-
ment of new psychochemicals. The program is providing fundamental informa-
tion bearing on the problem of structure activity relationships among these
compounds.
Z. The state of knowledge in areas of influencing human behavior
has been steadily improving and the experimental work being carried out
under this project is meeting our programmed needs. � The sponsor has
obtained and assigned highly competent technical personnel and is exerting
his best efforts to provide the data requirements imposed on him.
3. The cost of this program for a period of one year beginning
1 February 1960 is estimated to be $45, 000.00. To this sum must be added
$1,800.00 representing a four per cent service charge t
who will act as cut out, so that the total cost of
the project will not exceed $46,800.00. Charges should be made against
Allotment No. 0525-100 4902.
and that they return any un
the end of the grant period.
d funds
aining at
. It is not anticipated that any permanent equipment will be required
for this progra
6. It has been agreed that documentation. and accounting for travel
expenses which are reimbursable shall conform to the accepted practices
of the' organization conducting the research.
7. The requirement for a semi-annual informal accounting on the
part of the principal investigator has been waived.
8. All personnel connected with the planning and monitoring of this
program possess Ag..--.-mcy TOP SECRET approval. The pro ct will be unclassified
after it leaves t
APPROVED FOR OBLIGATION
OF FUNDS:
Date:
Attachments:
Budget and proposal
Distribution:
Original only
TSS emica Division
APPROVED;
-_ �
Chic
TSS/Chernical Division
BUDGET
Salaries
$28, 800
?,
�7, ZOO.
Overhead (25% of Salaries)
Travel
1,200
Services (Analytical, etc.)
_1, 800
/,Y;s2.0
�
Supplies and Materials
4, 200
Animals
1,800
/0-
Total $45-,- 000
December 31,1959
Grant for Pharmacological screening and testing
Funds received:
Exp
20, 500. 00
nditures
Wages and salaries 10, 907.60
Equipment 3, 623. 93
Supplies; expendables 1,303. 41
Animals 1, 783, 84
Overhead 2, 880. 60 _
20,A99.38
Total expenditures 20, 499. 38
Balance
.62
/3 .
9/ - =27
30 September 1.959
Gentlemen:
We are pleased to be able to transmit to you the following
funds:
drawn
rtg3oo
eck No. 22231F drawn on
for $20000.0O
These_funde-represent-a-contribution for the use of_your
directors_in carrying out the very votthithile -research goals _
of Your organization.
Tours itruly,
Enelosures_(2)
No
9/
Cost Account e9.6-AP. /07,Y. 4+0
Object Class
Date
and References
Obligations
Incurred
Obligations Unliquidated
Liquidated Balance
-AP 1959
�
�1
4
13 September 1959
UMORANDUMtQRCHUF. FINANCE DLYLSION
153/5u4get Officer
SUBJECT
14KULTRA; Subproject 91, luvolc. fa
Allotment 0525-1009-4901
1. Invoice No. 2 covert-as the abev subproject is attached.
Payment should be mtde as followss
Z. Pleas� forward the checks to Chief. TSS/Chernical
Division through /SS/Budget Officer by 7 October 1959.
3. This is a final invoice. However. since it is anticipated
that additional funds will be obligated for this project, the files
should not be closed.
Attachments:
Invoice k Cer ific
Distribution;
Or' kr= Addressee
Ody-4,73'
Chief
� TM/Chemical Division
L., C T
EC ErlEir.1.304-Ep
INVOICE
CERTIFICATIONS
(1) It is hereby certified that this is Invoice n applying to
Subproject 91 of 14KULTRATthat-performance is satiefactory, that
services are being accorstplished in accordance with mutual agree- _
mints, that a detailed agenda of the payments and receipts is filed
In T83/CD, that this bill is just and correct and that payment thereof
has not yet been made.
3/
Date:
NIFF.N�Ma
Chief, TSS/Chemical Division
(2)It is hereby certified that this invoice applile to Subproject 91
under MISULTRich was duly approved and that the project is
being carried out in accordance with the memorandum dated
13 April 1953 from the DCI to the DD/A. and the extension of this
authority in subsequent memoranda.
Date:
Research Director
CONFIDENTIAL FUNDS POSTING VOUCHER
VOUCHER NO. 7.12
DATE 2.6
VOUCHER NO. 1.12
1 DESCRIPTION.ALL OTHER ACCOUNTS 13.33
34.39
STATION
CODE
PROP. NO.
No.
40.42
EXPEND
CODE
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ACCT. NO.
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DATE 1
I
71.80
AMOUNT
: DESCRIPTION-
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4tg.
P.O. INO.
.".PROJECT
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FORM
6-59 606 USE PREVIOUS EDITIONS.
DRAFT
18 September 1959
MEMORANDUM FOR: THE RECORD
SUBJECT
: Supplement to Project MKULTRA, Subproject 91
1. The purpose of this supplement is to provide additional funds
to carry out an expanded animal screening of selected compounds directly
related to the development of new chemicals which influence human
behavior. The program provides fundamental information on structure-
activity relationships among new psychochemicals. It will provide an
insight into the activity of chemical compounds of possible value for
operational applications. The studies are directed toward elucidating
the relationship between this parameter and personality structure and
Z. In order to keep abreast of new co pounds hich have been
recently uncovered and synthesized, it becomes necessary to increase
the advanced animal screening. It is expected that results obtained
from the advanced screening will provide basic information required
for research into the pharmacodynamics of new and more effective
compounds. The additional funds required for this program for the year
amount to $20,000.00. To this sum must be added $800.00 representing
a four per cent service charge to
ho act as cut out, making the total amount $20,800.00.
Charges should be made against Allotment No. 05.254009-4902.
has requested
sub it to them a summary accounting of funds
or
received fro
and that they return any unused funds
remaining at the conclusion of the program.
4. It is not anticipated that any permanent equipment will be
required for this program.
5. It has been agreed that documentation a accounting for
travel expenses which are reimbursable by
conform to the accepted practice of that organization.
6. The requirement for a serni-annual informal accounting has
been waived.
7. All personnel connected with the planning and monitoring of
this program possess Agency TOP SECRET approval. The project will
be unclassified after it leaves
APPROVED FOR OBLIGATION
OF FUNDS:
Date:
Distribution:
Original only
TS cal Division
APPROVED:
TSS/Chemical Division
shall
Mt0LkNLUM fOR: COMPTROLL
FINANCE DIVISION
SUBJECT i 34KULTRA, Sabproject 91"
-
or the airthority grouted La the asszaoreadura dated
U April from the DCI to the DD/A-trid the eliteasioa 01
Ude sethovity La eubsotrieat arsattorsade, Subproject II bee
boea approved s& $20,1100.00 of the over-all 14KULTRA projoct
toads has Delo oblisated to cover the eabproject eapeaeos. Tide
obit sties of foods shoold be charged to Alloto: 0S2S-1009-4902.
A TTXTCTION
APPROV D 0 011
OF FUNDS:
search Director
Diattibwtioa:
Orli It i - A:We:rase
I = TSS/OC
I - TSS/FASB
-2�;-TS3/CD
TSS/C 185ept'59)
9/ 3 3
2 Pabruary 1959
Gentlemen;
We are pleased tote able to transmit to you the following
funds
These funda represent a eontributiOn for the 1.140 of your
-,direetors in-earrying out the very worthwhile researeb goals
of your organization.
trlayi
Snelosurea (2)
SZKOAMMNAl i azzip-rnmat masxos
tss/tuaaot Officer
MULTak, Subproject 91, InVOICO #1
Allotment 9-25C245,.902
ViA
ellBJICT
26 January 19$9
1. Invoice #1 covering the above subproject is attached.
Payment shoullbe made as foiiovss
2. Plea*, forma the checks to Chief, TSB/Chemical Division
through TSB/Padget Officer IrY $24041117, February 9,-1959.
3. This is a final invoice. Roveverp-since it is anticipated
that additional funds v111 be obligeted for this project, the files
Mould not be closed.
Attachmenta
Invoice A Certifications
1 stribution
g Arldrease.
CHECKJAVIN THE ANIcILINT OF
RECF.IVED.
4
Chief
TSB Chemical Division
CERTVICAITOSS
(1) It is hereby certifted that this is Invoice #1 spplying to
Subproject 91-Of MATRA, that performance is satisfactory, that
services are being accompliehed in a000riance with mutual agree.
outs, that adetailed mends of the-payments and receipts is filed
in TSS/bEr, that this bill is just and correct and that payment thereof
.has not it been 'saes
Dates
Wir"fflr�M-E""--"i, Mead vision
(2) It is hereby certified that this invoice applies to Subproject 91
under MULTRA-vhich vse-dulyepproved and that-the project is 'being
carried out in accordance vith the memorandum dated 13 _April 19,3 from
the DOI to the DOA, end the of this authority ia subsequent
memoranda.
lkesearabirettor
CONFIDENTIAL FUNDS POSTING VOUCHER
.. VOUCHER NO. 7. 12 DATE 2-6 I
.-
..,
VOUCHER NO. 7^ 12
DESCR IPTI ON- ALL OTHER ACCOUNTS 13-33 3A- 39
STATION ' 4042
45- 46
47. 52
OBL I G.
59- 67 68- 70 I
ALLOT. 1 DUE 7 I. 60
28- 33
CODE
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SI ,CIlIIcYIVG OFFICER
FORM ,A,
58 WU use PREV100 EPP 'EONS.
1.01CRIMI 031PMLak
AMMONs newts Dixie-ion
MT= PrNeet XKUMA, Dottro400t 91 :
Mier the wthority greatei is the foleuersodue 4404
13 ittPril 1953 fros the DU to the /A, *r4 the estmesioa of this
authority 1a. TaliatreaSt SatippljeCt 94 he* Uwe approved,
Kid 'OW2040 of the over-all project 14=M-fund5 has how
obligate& to (mew the tohprojeot's *versos so4 eboU34 be thargoti
to Mama% 9-2ge.75-9C2*
"--.."-UMWIlre."1"1""w""otor
Date
I MEN THAT MHOS AU AYAttAk.694
csioaricw 1Cat1r4 N., /03-
oiArca TO AITOT,4041 4e
Distritutioas
Cris 4 2 ii4dreasee
1 - T68/00
MAIM
1 - TS8/Bro3
2 - T58/CD
ISS/CD 5 17.21 59
AlittiORIZNQ Offla
- ;
9/37
DRAFT
15 January 1959
MORANDO/4 FOR THE RECORD
SUBJECT: Project NKULTRA, Subproject 91
1. The purpose of this subproject is to provide funds to carry
on the advanced animal screening and certain parts of the pre-clinical
pharmacology required by the program on the development of new psycho-
chemicals. In addition, this phase of the program viii. automatically
provide fundamental information bearing on the problem of the structure-
activity relationships among these compounds. It will, also give e. better
insight into the problem of compound selection for operational applica-
tions and the relationship betweenTarameter and the personality structure
of the particular person being studied.
2. Prelizinary_scree on the materials involved in this study has
gbeen carried out a over the past three
years. During this_time_t e eta e of knowledge in this area has steadily
improved so that it is no longer possible for the work to be carried out
by this contractor. The type of experimental work now required in the
program is simply far beyond his capability both in terms of equipment and
personnel required for-thW..--Ftt-this reason the rate of expenditure
Satellon this preliminary screening work has steadily dropped with time
while facilities capable of carrying-out the more advanced phases of the
program were being located. Thkpresent-vielt is that ht ove
glap during this year between these projects,
portion vill be phased out at the end of the year to be replaced
new facility.
3. The experimental design in this Subproject is based upon results
gderiVed frouvsUbprojecte,22i-,514770,-, 8-53,-46, 44, 45, theWOrk
of the past three years, and-prOjec The personnel and consultants
C! in 0 consist of CD Branch II personnel working with
Because the work leads off almost imme tely
Lnto completely own areas, all of these consultants will maintain a very
close but informal surveillance of the raw data as the work progresses so as
to be able to take advantage of every new development as it comes to light
in guiding further work in the project.
4. As indicated in the attached prbposal, the cost of this program
�for a period of one year will amount to $20,500.00. be added
tip. 4% service charge to th who
will act as cutout so that the otal-cost Of the pro eat exceed
$21,320.00. Charges should be made against allotment 9-250245-9020
5 The e reggested that
ubmit to them a summary tng of funds received
rcn that they return any unused funds remaining at
the cone usion 0 he pr
6. It is not anticipated that any permanent equipment will be
required for this phase of the program.
_7. It has been agreed that
expenses which are reimbursable b
the accepted practice of that org
8. The requirement for-a-semlannual informal accounting has been
waived.
count:40r travel
hall conform to
9. All personnel connected with the plopping and.maistspiping of
- results of this pr'- possess_ ency TOP SECRET approval, however none
Bof the personnelo with the exception _o
cleared and none will be made witting of Gov ere 8
will be unclassified after it letiVol-t
APPROVED FOR OBLIGATION OF FUNDS:
Date
'R seatc
),
Orig only.
Attachment - Proposal
TSS/Chemidal Division
9/ - .32
1-47
q4u^"
�PROPOSAL
It is proposed to conduct certain biological tests of a pharma,
cological nature as directed by the Sponsor of this project on chemical- =---- --
materials and extracts-to be-furnished by the Sponsor. These teats may -
involve enzyme preparations, small-animal vork and/or clinical vork in
certain cases as indicated-in each-particular instance. The Sponsor will
have full control of the methods and procedures-to be followed intbe work
and it is understood-that-these-will vary duritarthe course-of the project
depending upon research_findings7in-other fadilities.vorkingjnnthis sam-u
general biological program.
In additiOn,_asItime and flinds allow, pilot experiments will be per-
formed utilizing _various knowru-substances haVing effects on the central
nervous system-in an effort to refine and improve the present capability
of detecting and characterizing-such activity-in small animals Attention
viii also be given- to problem of extrapolation of results _between
various speciesof_animals
It is expected that-the attachea-budget-Vill be requiredto carryiout
the program outlined-abOve-for-a-period of one year.
BUDGET
.
Salaries . � � . .-� � . . ._ . � � . . 412,000
Overhead (25% of Salaries) . . . .. . .. 3,000
Travel . . . .._ ........ . � � . . 500 _ _
Serviee,(Analytical, -etc;) . � � � � � �- . 1)500,
Supplies and -Materials 3,000
Contingencies � � � � . . . � � � . 4 ..
500_
Total420,500
PROPOSAL
During the past few years a great deal of progress has been
made in relation to the function and metabolism of various anatomical
divisions of the human central nervous system. This progress has
to a great extent been fostered and abetted by the study of the effects
of drugs on this very complex system. These drugs have mainly been
utilized as tools in attempts to develop the relationships between
cerebral metabolic processes and brain functioa as expressed by
individual mood and behavioral changes.
In general, pharmacologists are just beginning to realize the
potentialities of work in this field and have not as yet adjusted their
research goals and techniques to take full advantage of existing
knowledge. The general tendency in this respect is to attempt to
apply sim pie modifications of existing techniques to the study of these
phenomena. This approach is useful but entirely inadequate to pro-
duce progress consistent with that in other fields of medical research.
A further problem of significance in relation to this work is the fact
that it has developed to a great extent on the clinical side with far too
little attention-paid to the general pharmacology of the drugs concerned.
Without such basic work progress will continue only on a pure chance
basis with little theoretical background.
Therefor4 it is proposed to:
1. Design and test methods involving experimental animals
which will discriminate between drug-produced generalized depressed
states and generalized excited states of the central nervous system
and thoise particular and_specific states or effects which can eventually
be related to overt behavioral responses of a sort which entail some
possibility of practical exploitation. In this process it would be ex-
pected that drugs having a more "pure" type of action than those
presently available would be discovered.
2. Discover and test materials having specific effects either
in the periphery or the central nervous system which result in the
distortion of nerve impulses in the sensory tracts of the nervous system.
3. Validate the above methods and effects in normal humans
and relate them to alterations in mood and behavior in as objective a
fashion as possible.
5v"
4. Establish and maintain facilities for those general
pharmacological procedures, i.e., the relationships of the unknown
drugs to the known humoral agents, etc., which are necessary in
order to describe intelligently the action of the new drugs for their
application in the above-mentioned tests.
It is felt on the basis of present knowledge that such a program
as that outlined above will go far to bridge the tremendous gap in
knowledge which presently exists between known drug-substrate
relationships and the overt manifestations of these drugs.
9/-
CURRICULUM yrrAE
Memberships: Society Experimental Biology
SocietyPh�lgyII
Cancer -Society
Academy of Medicine
Research: Conducted intensive research on: endocrine glands,
(insulin, posterior pituitary, thyroid, anterior
pituitary) chemotherapy, alcohol, virus and cancer.
Pharmacology of dinitrophenol