MKULTRA SUBPROJECT 70 (35 DOCUMENTS WITH PUBDATES FROM 570501 TO 640611 )

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00017471
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 57
• Document Creation Date: September 25, 2024
• Document Release Date: September 8, 1976
• Publication Date: May 1, 1957

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This Ls to oertlittbat w have the final actocaskting for
grants nu% to HOLM Sub.Project TO. The aocounting
beim retained TSD tiler" it nay 1* revleveil by tbo Corti.
Wing Officer upon reveat�
t Atrtbisr certWthat satlefactory writ*, bay* been
retoelveli_ana_that_to the beat of sty knovlexIge, the Atids &dm- _
oed for SUCh 11741rfieeill ire expended-for the purposeTriutbccli�ed
tbe project appr�ovel.,
�
OCUIUGI
(When Flitted In)
ACCOUNTING BY � IND I V I DUA L
FOR ADVANCE ,
4
4,407E: Follow Instructions on Reverse,
VOMITTE0 OT
, .
secoureAs floN,Prolort wi
IDATE . VOUCHER NO. 2.1
PER I OD , OF ACCOUNTING �
FROM
T
30_1Soverber 3,961
1. CASH ON HAND MEG INNING OF PERIOD
$
5. 5. EXPENSES THIS PERIOD;
2. OUTSTANDING ADVANCES BEG PRONG OF PER100
,
'
VOuCHER
NURSER
DATE
DESCRIPTION
� AMOUNT
3. RECEIPTS THIS PER1001
Se& littachaa Cipirt/ettura gen
I
RECEIPT
NUmBER
1 DATE
DESCRIPTION
I
'tab� Z52r1,5
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.
firm. 4 it-
1
1 1 1
TOTAL EXPENSES
11.
6. REFUNDED:HEBER!".
I IcAs I IL IC Cc6 ImONsv 844
� OUTSTANDINGADVANC
511 ENDi OFHPER40011(Att688 li
Ain�,
I V
i
*. CASH ON HAND
IEND I
Of PERIOD ORHOALANCUOUE A0Vo44CEE
,
� TOTAL TO ACCOUNT FOR 1
422,00
11
6. H�llild'd1 1
II
k HEOTAL.ACCOUNTED
FOR 'I
1 1 IS 11/422.00
CERTIFY FUNDS ARE AVAILABLE
II APPROVED
:.
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DATE
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CERTIFIED
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NATURE
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SIGNATURE
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USE OF OFFICE OF FINANCE-
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OCSCRIPTION.ALI. OTHER
ACCOUNTS 13.33
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CODE 1.
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.PER.
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INCRTVICA-.
this is to certify that 1,4 hive tbgt final accounting for
greats sada WilLTRA Sub7.1Yoject770* The accoutking is
biting rataing4 in TED vbere it Ley be revievesi t tbs Certi-
Wind Officer won requests

I. iNgrtbsr certify that satisfactory services have beta
receive4 saA. that_to_thstAnst_of_rfy loloviedea, the funds atirTin-
+:*1 fat such services_vere_expoled for ths mose-autborised
by the yroject apyrovals
cae_Sclentist,
. jam
SUBMITTED BY
,DATE � VOUCHER NO. 2.12
ACCOUNTING BY INDIVIDUAL
FOR ADVANCE
NOTE Follow inetructions on Revere.
CAS4 ON NANO BEGINNING OF PERIOD
2. OUTSTANDING ADVANCES SEGINNING OF PERsoo
TRA, sub-Proje.et 70
PER 100 OF ACCOUNTING
ON
3. RECEIPTS THIS PERIOD,
ECEeP
UMBER
.OAT(
DESCRIPT I ON
7_6(.M___2531018
comp
may 4 mai-814
TOTAL TO ACCOUNT FOR
CE TIFY FUN
S ARE AVM'
A LE
* 1)&22.00
$ 4'122.00
APPROVED
TO
Remember 1961
1.34)
S. EXPENSES THIS PERIOD,
VOUCHER .DATE 1 DESCRIPTION
NUMBER MOUNT
9
I 1,1 I
See Atteebett Certifleatierk 422.M.
ITOTAL
Acco,uNTE0 Fop
ODLIG. EF. NO.
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SIGNATURE OF ,APPROVING EoFFice; 1
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PAYMENT OR CREO 1
DATE
SIGNATURE OF CERTIFYING
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!;
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f certify thee he expendrea; limited hereon an
"11)."T 4,Jetechmentn wet. incurred for, officiatpur.
poaeo ofljall'tonfidentiall attire, that payment or
credit therefor ;hal moil; been received. lend ' theA
Clii. account me is true and COffeer.
SIGNATURE OF PAYEE
SPACE;BELOWfOR EXCLUSIVE USE OF OFF CEIOF FINANCE;;;
CROPTION.ALL OTHER. ACCOUNTS 13.33
I
I
DESCRIPTION
ADVANCE ACCOUNTS
2
20.3
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91.154
;GENERAL
LEOGER
ACCT. NO
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COSY � FAN
ACCOUNT SVmSOU I 1'
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$7.70
ORJECT
CLASS
AMOUNT
10:
do �
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:No.
� l�
O
Nc!r. No.;
: DUE
'400E I.
DEBIT
CRIED IT
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DATE
REPAIRED SY .1
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DATE
FORM Finn
� .404 Ltsri:Imv
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I.
MOW= PUT TM{ =CD
1/ June 1964
!MEM MMTRA-SaVro4iW4 7�, 51, $4 �al 135
7O1
Since the:cctipletion_of the audit_cd_PrOject NICULVA for_thoeri
1960 t4rpuel-31,-,k**:tx 1963,�id-66tiattatta have been received - �
I n the amount of $93,67(;23. -5114 ambunt
117.93 balance to he accounted to_by
tees at the end of the audit perioL-
Ouhproject_70-ineUkrod-diroot coats of $2,518:34 and t27,872.16
transferred fros_Subprojett 941 for a total of 430,350.50. Subproject : �
imeurred expenses:Of-471,324.87, but Usneforred 0,165.71 to albpro-
4act 91 at t2bap.3:6_towaTcoevt, 7, 1as7ir( a net _ COSt _of39,2O0.
It vas decidolito_divert_the_fumds_for_aftroject 135 to SUbproject
therefore theaseccosts_vere_inalddod in_W4 accounting-from $ubyrolect 91.
Tnasmuch as; 1) sal four of tho subprojecta bad the_sameAtasic re-
search goal inland,- =2) the great length of time thatkos_elaysod,sicos
the grants uere madeiand -3) the difficulty In getting accountings of
any sort from-the-grantee, it is recomended that loa facilitate_this_mat
ter toratcounting for the balances as bova in-the Confidential nods_
41,
ofthe Audit
Division, 760 account-for these_subprovts.
The above has teen concUrred in by
Staff. .
Chief Scientist TW
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lad In)
1 SUBMIT-TED BY �
VOUCHER no. (Finance woe only)
ACCOUNTING BY INDIVIDUAL
IPLKOZXRA Sub 70 .
FOR ADVANCE
.. ,
PERIOD,OF ACCOUNTING
oe'.'
NOTE: Follow Instructions on R
FROM 5
1 Oototecr 1960 . .
TO
30 FicToptbeir 1961
, � RECEIPTS
DISBURSEMENTS
I. EAsol ON HAND 8EGINNING OF PERIOD
s
VOUCHER
3. NUMIIER
DATE
OESCRIPTION
AMOUNT
%a.
2 WI:17
DATE
DESCRIPTIO
rov
1,12MILTRA Advance
.,....
Xnvooe
IBLI..�
390.50
� ttaatbadfication
1
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11
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TOTAL EXPENSES !
3a.
A: REFUNDO
HEREWITH
III CAIN
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&IONE..., ORDEM
1
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TOTAL TO ACCOUNT FOP
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OBLIGATION REFERENCENO.
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DAT"
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RESEARCHADISLEEP�AND 1JNCONSCIOUSNESS -(PROJECT_ 520 W)
October 1 1960 To November 30
1961 -
.
Grant Income
$ 33,390.50
Costs - October 1, 1960 To November 30 1961 -
Salaries
$ 1,580.25
61.77
Payroll Taxes�and Insurance
Laboratory Supplies-and Expense
408.47
2,050,59
Allocation ofGand- A Expense
467.75
2 518.34
27,872,16
_27872.16 r
Transfer of Costs=from-Project 510 WSW)
,
(When Filled Filled In)
CONFIDENTIAL FUNDS POSTING VOUCHER
VOUCHER NO. 7-12
DATE 2-6
VOUCHER NO. 7'12
DESCRIPTION-ALL 0 HER ACCOUNTS 131.33
34.39
STATION
40-42
CODE
43
f
U
N
45 .4
PAY
PER.
tc.;:i
47.52 1
ODLIGJ
REF. NO.
2c"4
EMP. AO.
53
CA
VA
54.57
GENERAL
58.67
ALLOT. OR COST
ACCT. NO.
68-70
DUE
DATE
71-80
. AMOUNT
DESCRIPTION-
ADVANCE ACCOUNTS 13.27
p.o. No.
:z..33.0�,,,,,c,
olovJ
CODE 'EXPEND
PROP. NO.
.z.
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ACCT. NO.
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EXPLANATION OF ENTRY
TOTALS
1
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DATE
PREPARED RV
DATE
REV (WED OV
CERT IF IED FOR PAYMCREDT
7 /1
1
DATE
1 SIGNATURE
V MI .. I FFIC
11414"C
'
FORM
110.5, 06 USE INEVIOUS EDIYIONS.
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.MOMMOIMOIM=MMft,
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10.49)
3 Jorember 1
MEMORAIDURFORI CHIK441KADC3 -DIVIZION-
VIA _TSD/Dudget Officer
VIND7r MUM, Sibpro4ect No. 70 Invoice
NO-. 4, Allotment 1123-,1009.1902
10InvOiee No. 14 in the amount of $33,028.12 covering
the atcme7sUbproject is attached. Bowyer duo-to refunds of
$1,422.00 froaother_Projects (aa per attaehments) payment
should be made as follow:
2.-Iblease_forvard_the_checks to Chiefs:MD/Research
Branch, through MO-mast �triter, no, later than ThLitetelah
17 Itommter_1960.
3. This is a final inlViCa� BOVOYer, FkinCa=it-i$ -
anticipated that additional fUOds vill7be obligated-for this
project, the files should not be closed. !
Chief
V...D/Fie search Braiich
AttaChaantal
Invo/ce_&-Ce�rtifieationg _ EC Ki1,1
Distribution:
Orig& 2 4. Addressee
1 - TSD/FASS
Y
C i=a1ro�OlrrA*1--
(3) It is hereby certified that the prograe under Subproject 72
has been satiafactorily completed ancl returned iarrused Amiss Now.
evert Subproject_70Iwhich is still continuing also refunded money
which vas-left over at _cutout from previous grant. Itereforeo it
is requested that the amounts as shown below on Invoice N. 4, of
Subproject 70 be credited to the subprojects u shove
Amount NOR Allotment
#72 072.03 2769 7-2502-10-001
)70 1150.00 571 0525.-.104094901 _
Date:
Date:
-51-er,-TraD e�T's-r---arch-Branch
Re search Dire
INVOI
For SerVices
32
.worammtAira,wksa.mwardsuembammalkoomawiratrimpa4swomwavirimswartalwsowir drwawywma,qgroweww ammo."
CIRTIFICATIONS
(1) It Is hereby certified that this is Invoice No. 4 applying
to Subproject 70 cf-MKULTRA, that performance is satisfactory,
that services are being accomplished in accordance -with mutual
agreemente, that a detalled_agenda of the payments and receipts__
is filed in TD/R3, thet this bill is juatend correct andi that
payment thereof has not yet been made.
aief, TSD/SescarCh7Branch
Datei
(2) it is hereby certified that this lnyoice applies to Subproject
70 under 140.11,11WV1lie2 vas duly approved am% that the projeot Ss
being carried out in accord:Mee lath the meracTend= dated 13 April
1953 from the Da1to_tbelD0/A, and the extebeion-_of this authorit
in subsequentimemoranies
De.te:
aD
1^
(3) It is hereby certified that the program uMer Subproject 72
has been satisfactorily congested -and returned %mused Auld*. Sow.
ever, Subproject 70,LiCh is stilt continuing-also refunded money
which vas left oNtrat cutout from previous grant. Therefore, it
is requested that the anwunts as shaitn below ci invoice No. k of
Subproject 70 be credited to the subprojects as shcArn, below.
Date
Date:
trpject __Amount MOS Allotment
#72. *72_40� 2768
14509,CO, - 571 0525T1009-11902--
PrO
sw- riisear groxicli
Reses.rch�Director
aSawesrase
TO; TSS/OC
I. Date of Obligation:
2. Purpose of Project: To conduct research
to define mechanisms involved in production
of involuntary sleep,. and related unconscious
statest.
A�Progress to Date:
Satisfactory
ratioa-Dau: 31 September 1961
5. Project Mato :
FROPIITSSIX RB
Room IVNIC West 04.T3bUildinf,, al*** Xbaint
119 2292
DoWngeaded
- by autheri*
14 October 1960
MEMORANDUM-FOR; THE RECORD
SUBJECT - ; MKULTR.A, Subproject No. 70-
-
1. The purpose otthis subproject is to provide funds for
coatinuation_of research on the "K" (uncosciousraese producing)
problem.
Z. There exists within the Agency a continuing require-
ment for highly potent, quick-acting substances that will rtncler
an individual helpless and immobile, preferably in an unconscious
state. It is anticipated that this program will provide funda.mental
information needed for soliTtion oflhis problem. -The-s-cope of
thip research program is intended to cover investigations on the
mechanisms in which certain drugs induce anesthesia or narcosis,
elucidate the basic mechanisms of action involved and uncover and
evaluate materials_which have value because of their potency, phy-
sical characteristics, and biological activity.
3. While information and materials available to date are
inadequate to satisfy Agency requirements, there are model com-
pounds which ,�_because of their potency, biological activity, or
Downgraded to: tiTAI--
by authority of: tag"
date: June 1977
IMFDET ; CIA Bygsgs,
JOP SECP;F:
IM?DET; CL BY4110011114
chemical characteristics, permit a prediction that an adequate
research program-stands a good chance of developing an under-
standing of the mechanism a.nd should result in the development
of a material suitable for operational use.
4. The-
will serve
as cut out and cover for this eubprojet. The necessary research
and development will-tie' conducted throug
will submit to th
mary alecounting of funds received from the foundation and will re-
tura any unused funds remainOg at the conclusion-of the program.
The estimated_cost of the work for a period of one year is $31,812.50.
To thii sum must be added_a four per cent service-charge for the
;Ali=
amounting to $1,272.48 making
the total cost of thia program $33,084.98.
Total cost of the project for one year will not exceed
$33,084.98. Charges should be made against Allotment No. 1525-
1009-1902.
6. It is not anticipated that any permanent equipment will.
be required for this program.
7. Documentation and accounting for travel expenses which
are reimbursable by
Dom73z' :d t mmina
� b7 au! ,orit of:
extt . jIbn 1977
T; CL BY
�11. conform to the ac-
�
cepted practices of that organization.
8. The requirement for a semi-annual in orrnal accounting
on the part of the investigator is',v.Paived'.
/5
9. All personnel connected with the planning and monitoring
of results of this program possess TOP SECRET approva � The pro-
ject is unclassified after it leaves tht
TSDIResearch Branch
APPROVED FOR�OBLIGATION
OF FUNDS:
Date: (
Resear_ch ector
Attachment:
Proposed Budget
Distribution:
Original only
0: COMINTIV.
.7 of
1977
; CI! Ety�
19^
MSEARCHIPROPOSAL
_
It is proposed to continue basic resesrohTonisleep
and unconsciousnessialOng-the-lints laid down7by-the Sponsor
and hisLtechnical consultanta. principalIinvestigator will
exert-hisAestefforts in conduting research_to_deflne_the___
mechanisms-underlying proill&tion of involuntary sleep and to
differentiate_the_mechaniams involvedr in the7production of_this__
form of_unconsciousness from other states ot_unconsciousness-or_
rented_behavior Because of generally poorstate_of knowledge
in this area-of work and furthermore, because_of_the peculiar_ _____
requirements_of_the_SponsOr as distinguished frnm tee: usual medical
requirements, it is understood that the major framework of the research
design:for_this work Will be provided_by the Sponsor.
Reports will-be rendered on progress of such studies and
investigations as significant advances are accomplieled. _
ESTIMATED BUDGET
� aiff���
SALARIES:
Bio-Chemist $10, 000. 00
Pharmacologist _ 7, 500, 00
Anim.al_Ctaker 1, COO. 00
_
OAS' State-Unemployment Ins.
1,850.
00
00
Supplies and Expendable Materials
2
000.
Animals and Feed
2,
000.
00
600.
00
R eproduction ervice s
Travel
500.
00
IIMIEMIOMIREMEN4
Subtotal $25,450.00
Overhead (25% of.total 6, 362. 50
TOTAL $31, 812. 50
Grant for : NeuxophySiological Effects of Sedative Agents
Financial Statement
June 1.1958 to July 1, 1959
Funds received _
Expenditures:
19,800.00
Wages & salaries
Equipment
1,543. 86
Supplies
1,04861
Overhead
3,134.94
Total expenditures - 25527.41
Balance July 1,1959 ( ( $ 100.41)
July 2, 1959
l'ave tha
;
Grant for: Besearch-on SleeVamd Unconsciousness
�
Amount of G
E____E41.1aEtt -
M.M-1011DMINIM MS al Silk 4.13 0 900 00 -
. .
Salaries and Wages $12,824.60
Materials�and-Supplies 9212.97 .
Travel -
Services
Social-Sm., Ins, etc. __
Overhead
_153.92-
3,26.94i
1-4636-.W
3,206.15,
301,90/.00. '0;900.00
Balance
-
_
(When Filled In)
No
dr,/
Cost Aecotint /ffi,e
Object Class
Date

'Remarks and ReferencesIncurred
Obligations _
_ ligatio
Obligations
Liquidated
Dnliquidated
Balance
27 P9c6re.
_
�Id .
7 -I (ize-gi _
asay,9,
v 1560
i:_4_____
,
1,1 2
,
-- -
--
-
:
TI
_
.
..
_
,
'4E*eRtrrw""a6*4fts.�.-
(When Filled In)
14 October 1940
MEMORANDUM OR: COMPTROLLER
ATTENTION : Finance DIvisloa
SUBJECT MKULTRA, Subproject No. 70
Additional_Authorization No. 3
Ueder the aulnority granted la the mernorandana_dated
13 April 1953 from the DC1 to the DNA. and the eagle:taloa of
this authority in subsequent naernoranSa. Sub-project 70 ha
been approved and $33.0784;98 eiThe over-all 14KULTR A pro.
ject luude hiie been obligated to etre.? the subproject expenses.
This obligation of fUnds sbi�1d be charged to Allotment 1525-
10094902._
TSD/Research Branch
� APPROVED-1'0R OBLIGATION
OIP FUNDS:
Research Director
Date:
DIstributtoo:
Orig. & Z � Mdressee
TSD/OC
ve. TSD/FASS
Z TSD/RB
TSD/RB 14 Oct. '60)
ef/4
7 January 1960
MEMORANDUM FOR :__THE RECORDiITIT
SUBJECT : Action on MKULTRA Audit Exceptions - TSS/CD
SP#70
The $450,00 balance, expenditure of which was unaccounted
for in this folder, is being held in th vow
account and will be returned.
Chief
TSS/Chemical Division
18_Ju1y 1960
Recent_technical develorments and-the continuing availability of \
adequate research-facilities-,--along with tbe increased pressure -
on the-production of a practil end. product related tithis
projvt, indicate-that there vill be a continuing and, probably
increased.-effort in this area. In view of-this, it has been decided
that the funds mentioned above yill be retained for use in connection
with the next re-financing of this project, rather than being carried
over to scime_other_subproject by the usual- procedure-i- This project
Will, as-presently scheduled,- be refinanced on-a-continuing basis in-
October 1960.
30 October 1959
MEMORANDUM FOR: THE RECORD
SUBJECT
: MKULTRA NO. 70
The following endorsed and cancelled checks (photostat
copies) issued by the
re
applicable to MKULTR4t No. 70. They are for salary expenditures
on this subproject and are held in lieu of formal receipts which were
not requested. Th
normally_require_receipts for salary checks which endorsed,- cashed,
or deposited constitute_acknowledgment of payment, -
VAC-1 Aug 13, 1957 . $1500
#105 Oct 1, 1957 . $1500
#114 Jan 2, 1958 $1500
1122 Apr 1, 1958 ' $1500
Distribution:
Orig only.
Total $6000
TSSiChemical Division
"Late
Gentlemen:
funds:
z
September 30, 1959
We are pieadto be able to transmit to you the 1foflovl
Csshi r Chedk No. 00635 dravn on the
for $30,900-.00.
Treasurer's check - No. 2.235 drawn on
for 4,236.00,
Theae funds represent a contribution for tbe_use or your
directors in carrying out the very vorthvhile researCh-goals-of your
organization.
Encl.
sir -trulI
No. �7,
Cost Account
AO. 'mar! "eriA
Object Class
Date
Obligations
Liquidated
Unliquidated
BsJuice
Obligations
Incurred
Remarks and References
- --
96
-w
25 ilii
do . 4,..."
�
.
.� _ _-_ ___ _ _
�
. _......... .__
_
.
...,
_
,
-
-1
�
23_S4ptealbor 195
MEMORANDUM FOR: CHIEF, FINANCE DIVISION
VIA ITSS/Budget Officer.
suarECT ILICULTRASubprojoict 70, InvoLce #3
Allotment 05ZS4009-4902
�1. lavoice 13 coveriag the above subproject Is attached.
Payment_sho_uld b_e_rnalle as. follows:
Casblees_chi-ck in the asng� $30.900.00.
drawn on payable to
2. Please forward the checks to Chief, TSS/Chernical
Division. through TS3/An3get Officer, no later than Wednesday.
7 October 1959.
� 3. 'This is a ftcal. invoice. However, since it is anticipated
that additional funds will be obligated for this_project..the files
should not b_st closed.
Attachments:
Invoice k Certificationps
Dietributio
Orig fa� Addressee
*. 'NEC EIVZD
30 5-E?
rbao.-f
(When Filled In)
�
CONF IDENTIAL FUNDS POSTING VOUCHER
VOUCHER NO. 7-112
DATE 2-4
VOUCHER NO. 7-12
�����,
DESCRIPTION-ALL OTHER ACCOUNTI OX-SS 34.34
STATION 140,42
CODE SCRIPTION EXPEND
p.o.
ADVANCE ACCOUNTS IX.XT NO. ...... . cope
PROP. NO.
DE-
' � t .5f.$21 �701.0.S.C.0 N7C7.
00*+
.....
... ..... : :
:1-12; 3'te-Y 4;
� � � � � �
.1)./e. 0, � � � �/ �
� � � � � �
...
ea
44.44
PAT
PER.
110.
CODE
47-52
OWL 40.
REF. NO.
tecve5A.
AMP. NO.
-
CA
TR
54-S7
GENERAL
LEDGER
ACCT. NO.
54-67
ALLOT. OR COST
ACCT. NO.
42.07
CA.AO.
A NAP. NO.
9-70
DUE
DATE
71-40
� AMOUNT
00.0[CT
CLASS
, ,
*.�
(4-
0 � �
:t:
. .
�
.�
IAVL / '35
�
� � �
� � .
... .....
�
�
� �
F-100�0-������������,*����-��������--.-
� 0 �
.EXPLAWATION OF
ENTRY
, TOTALS
r
DATE
PREPARED (11,
DATE
REVIEWED WV
I
FORM ,
4-540 OW) unt intriv
enoTgome.
DATE
I
i� r /
CERT F 1E0 FOR PAYMENT OR CR 01 IT
TURE OF CERTIFYING
(40. 4
urrotcr-
For Services
..
$32.136. 00 -
fitatWA� IWO . Oft0001,04, WWWWW -OM WW 41.10.4�4040MMWWW
CRRTIFICATIONS�
(1) it is hereby cert.ifi*d-that this La Invoice #3 applying to
Subproject 70 of MICULTRAthat perfo-rmance is satisfactory,
- that services are being accomplished in accordance with mutual
agreements, that a dstail4fd agenda of thti+ payments acid receipts
is filed in TSS/CD, that this bill is just-and corract and that pay-
ment thereof has not yet been made.
Date:
Chief, TSS/Chemical Division
� (2) It isThereby-cortifled th-at this Invoice applies to Subproject 70-
under IIKULTR-A which was duly approved and that the project is
being carried ont in accordivn-ce-with the merooranduzzi dated
13 April 1953-from the Da to the DIVA, and the extension of this
authority In subsequent memoranda.
Date:
Research Director
xsaara za
ce5FMINTIAL
of:
1977
111FDLT; CL Byelaw.'
MEMORANDUM FOR: THE RECORD
D R AFT
18 September 1959
SUBJECT : MKULTRA, Subproject 70
1. The purpose of this subproject is to provide funds for a
. air
continuatioa of research on_the "K" (knock--out) problem.
2. There existsvithin the Agency a continuing requirement for
highly potent, quick-acting substances that will reader an Individual
helpless -and immobile, preferably in an unconscious-state. It is
anticipated that_thie_program will provide fundamental information
needed for solutiorL0f_this_pr_oigelyt, The scop.e-of this research
program is intended to cover investigations on the manner in which
certain drugs induce anesthesia or narcosis, elucidate the mechanism
of action-of such compounds and uncover and evaluate materials
which have pateatial value because of their potency, physical
characteristics, and biological activity.
3. While information and materials available_to (late are
inadequate to satisfy Ageacy requirements, there are model compouads lii_
which, because of their-potency, biological activity, or chemical
characteristics, permit a prediction that an adequate research program
stands a-good chance of developing a material suitable for operational
Do-
by
dat
of:
1977
'MET; CL BY
-2-
cut out and cover for this subproject. The neces research and
development_ ill be conducted b�
mit to h
who will suba-
a summary account-
ing of funds received from the foundation and willreturnanyunu.ed
funds remaining at the conclusion of the program. The estimated _
�
cost of the_work for a period of one year is $30,900.00. To this sum
must be added a four_per cent service charge for_the
amounting to $1, 236.00 making the total
coat of this_program $32,136.00.
5;-Total cost_of the_project for one year-will aot exceed
$32,136.00. Charges should be made against Allotment No. 0525-
1009-4902.
6. It is not anticipated that any p rmanent equipment will
be required for this program.
Document.a.tion and accounting for travel expenses which
are reimbursable by will conform to the-accepted
J
practices-of thatorganization.
8. The requirement for a semi-annual informal accounting on
the part ci the principal iavestigator is waived.
NV:13ra ed to erVc""1"1"1
by et rity of:-
eato Juzo
-
Do
iriaintirdlit/W ����\
y of:
o1977
�2 ; Cis BYVOIllakmir
9. All personnel contiesied_with the planning and monitoring
Downgt-
-
by
-
of results of this program possess TOP SECRET approval. The
project is unclassified after it leaves the
APPROVED FOR OBLIGATION
OF FUNDS:
Date:
TSS/Chemical Division
APPROVED:
� 'Chief
e earch '%rector
TSS/Chernical Division
Attachment:
Proposed Budget
Distribution:
Original only
to: CURIUMt
ty of:
3 1977
CL
-��54
PROPOrED�BVIMET-7
500.
00
Salaries$22,
Overhead (ZO% of salaries)
4
500.
00
2400.
00
Supplies arid materials
1,
000.
00
Surviges
500.
00
Travel
$30;900.
00
�
4
� sow-abet 1959
14.0d0RAI4dUht FOla: CObdPTROLLZit
ATTENTION . : InJ111446 Divides
31111JEGT 14KU1411.4._$_ehpreisat
� 171toltitt Ott sotherity gssated it the otsznottoduro_datsd
�
U Ara 19S3 ism the DC t to thii-DIVA, t$ the eitsasioss of
- this sathosity it sebsottotot raszoonioda, Sobproject 70 Ms
beteg tppeeved tad SSZe U6.00of tk. ever-s11,14KULTBA projec
funds has best ohligat4d to cover this sebproject Sepsesss. This
obligitloo of foods *Mold bt charged to Allotment 0$15-1009.A902.
APPROVED-r0
Or FUNDS:
TS'S/Chemical Divisloo
OBT.IGAT LON
Ross:ire% rector
.batst
Distribution:
*rig & Addrassis
"AL �
OFFICE OP CONTROLLER
Fianial-Statement
Ju1y_4_1957_to_June 30,_1958:
Funds received-L_
Expenditures:
41�1111.
/ $15;39000\:i1
I
-Salaries $10,164.54- -
Animal_Houses 2,73119
General_Sunplies 367.88
Tr�:Honorariu 85.00
Overhead -
Total Expenditures Balance aine-A0958-(Deficit)
June 23,1959 -
15,438.61.
($, 48.61)
Assistant-Controller
haver.examinedtfld:ApprOVtd tbe submitt047.--
AxpendIttito8,j- - -
Date:
Chie
TSS/Cbsmical Division
.MEMORANDUM-FOR THE RECORD
_
SUBJECT Request for Authorization of Changer
MKULTRA #90
�.
1: Authorizatioil to use outaid laborator facility requested by
letter 9 June .1958 fro
received 11 June 1958.
Z. Verb�al authorization granted (by te1ephone)12 June 1958.
WAR OT
SE' ty NTE
SOUR AN M D'VOLVO.
4
I
June 9,1958
� In view of a moving .,
from' u .wn t in the first part of the coming year, and
-the resultant limitation of space and curtailment of activities, it is requested
that authorization be'sgiven by you to the Foundation to have the second year of
--researc activities on the art o
be p1ced1h an outside.laboratory fact -
lity.
A letter fro- requesting the change is attached hereto for your
perusal. There are no_objections-on the part of the Foundation to the chanp.
ICindly notify us at your earliest convenience of your decision.
Sincerel
ecu ve_Secretary - Treasurer
SITI INV" E
SOL CES AND M._ 110 INVOLVED
- emu e
44,
MEMORANDUM FOR: The Record
'SUBJECT : Authorization for Facility Chahg , M ULTRA/70
. By letter dated 5 June 1958 from
request was made for permission to_use outside facilities
to continue second year-of_research.
2. Verbal authorization. for requested change la facility was
granted 9 June 1958.
As you know,- the is moving from
In the early part of the coming year. On a phasing out schechile,
many of the Departments, including Neurology, are to commence moving of
facilities and personnel starting January 1959. You can not imagine the chaos

and turmoil already in progress. For all intent and purpose, 'I would say that
any productive work mould not be forthc,orang for the next two, if not three ,
fears.
Since the completion of the nevurnedical school behind schedule, it
would be difficult to predict when adequate space will be availablfor all the
different departments. It ha l�eady been determhled-Ufat doubling up of both
research and clinic space will be the order of the day, :
As an interbil procedure, many of the research sections have looked to
the use of outside laboratory facilities to fill the gap that will exist at school.
The University recopizes the urgent need and necessity of outside facilities
and will authorize the use of same.
In order to conduct my activities in a smooth and orderly fashion, I
would like pe,nnissiorcto place my second year of research in-an-outside
oratory facility, namely,
AM* Preliminary-discussions-With the De4n of the Medical School show no
objections on his part to the use of the facility.
mat
If the relocation of the research project is accecptable, please notify
me at the earliest opportunity. Your support has been greatly appreciated.
Yours trtaic
Associate Clinical Profesor
1
Atlas t
Vs are pleased, to be able to transmit to you the folloving
cb4a--118 1246
3 dra
945.24.r.
- Mese funts represent a contribution forthe_use_of_your
direetorivin-LcazTying out the very vorthvbile research goalvof -
your organization.
trtcl.
OUrY- -1113.,y
,�11
CbiKka4e1 Ditision
MAT 'NAP-MI.1f
- -
Distribution*
Orig & 2 � Addressee
4..41
4/77 0
-� 1113
:
� ;des �
mitawrotat CaMis, nun= DITISICY
VIA as' ISSIbudeet �Moor
soon wanaR4 subyroNt To, inoraol
Anotatilt_74932,4o-co1
1. Tavola. So., 2 eovertos the above subproject is attathed.
Pteleent should be made as Wiwi:
Cafehterte check stamot at $2%10.2.001
to Paltainfsr
Cathie:Os Check in the amount or $945,2h
Areva-4:4 a to 7--
2. Please format the cbsoiks to CWiti /C cal Divisions
tkrou& WA/Budget Officer, no later then Wedaesley, 28 Hey 1953.
3. %sit tarot** revestate ther total &moat current/y author*
Lod volariAltItatjact 70. Bowever, since it is anticipated that
additicoallfUndsoirill taLARNIAgatad for this project, the files thoad-
pot be closed. ,
Attecheentis:
ToYoke Ce�rtificatione
J1,1,LIPs
"
- 1..1:�f:
A.J.
F
v.:�..; _
CISTIFICATIONI
selilit heteby certified-that this is Undo, fa applying to Subproject
of XICULTRAi that porton:woe is astisfactory,-that services are
being accomplished in accordence with matual agreements, that a detailed
sgenda of_the payments anl receipts is on file in TB8/CD, that this bill
is just ard *moot and that meant thereof has-not ret been cad**
Dates
(2) It is_hareby oertiSisUthatthiir invoice applies to Subproject &
of $1311101A-uLich vas _duly approved, t4 that the project is being carried
out in accordance with the_meteorandum dated-13 April 453 froa the COI
to the DD/A, and the extsnsico of this authority in all:sect/eat aemorands.
ftetarch Director
- ;ow
28_Axivist 1.957
.�
Ve araLpletted to be able to transmWto you.the
follotringlundst
Chiek drew oft tbe
fOr tai840-.00-
2774 &min ott the
for 4945.24 r f,
Mese funds represent a contribution for the use-of your
dIreotorsillt darning out the very vorthvhile researdh-goals of
your organisation,- -
September 11 1957� -
Thu is to acknowledge the receipt of the following checksi
for $21,840.00
-442774 drawn on
r$94524 _
YoUr generous contribudons are irreatly Jppreciated. The fund/Will be
utilized by otrr Board_of_Dtrectors Le7.1!inhering worthwhile, research projects in
the field of medical. sciences�
�
Your s truly,
ia � :
Ilterf_OFFtet DIP/ATM
CellinAt eus,ains=i
4,11
PIP64.11 FOR illtreuell 1St Ttl ar341
Mr NEN? OF PC.PAGL
OEM
MilITRUCTIOK1.-44ow RAMO. addreta and rioinber of
bafos..� Coarptota "Instructions To Deliaerinj
on 01?.! aide, when appbeabta.Moisten
lkaanatild apa and 'pourer attach ,o back of muckier.- In.
' � itoNat.,-vaf'` �
ikon trent et article- RIQUISIED.
�an
fiTal
0 r
FACE F
R fr"-
w-ttatt-4
�
:MEMORANDUM FOR: MEP', FINANCE DIVISION
Y/41 TSS/IWIdget OUIcer

SUBJECTi IttlfULTP.A, Sobproject_t0. lirt*IC41 11
Allotivaot 7-2S02-10A)01
haveteis it cov4ring the above subproject le attached.
. Other 10VOLC4111 Win 60110W. It it requested that payment bit made
is follows;
Z. This clitit stuiuld be forwarded to_Clatef, TSSiChemic
DIvIsloa through 133i Bidget Officer, st4n later_thaa _Friday,
'12-='-::-'W/.3 16 Auguet 1957: _
�r. elite: -
lavolce sod CeStlficetIons�
DIstribution:
Ortiz &2 - Addrestee
- Comptroller
TSS/FASB
Z TSSLCD
..Vbairitromainwww. .
I i
4.1Q'
w.01
� IN IR WIN �a'� 111,0-411 4,0,11,10 a I! WV ;ID � MOO Mt SIAS 0-611_MILMa ==
cERTLFICATIONS
�
(1) It is hereby certified that this is Invoice 11 applying to Subproject
170 of MICULTRA, that performance is satisfactory,- that services are
being accomplished In accordance with mutual agreements, that a
detailed agenda of the payments and receipts is on file_in_TSS/CD� thTit
this bill le just and correct and that payment thereof has not yet be-en -
made. -
� '
sm..11
Actizig Chief, TSS/Chemical Division
.1
(2) It is hereby ceitilii-d-that-this Invoice applies-to Subproject 170 of -
ItICULTRA_which was duly approved, and that-tbe-project is being
carried out in-icordazicevrith_the memorandum dated 13 April 1953
from the DC/ to the DD/A, and the- extension of this authority in sub-;
sequent memoranda.
Date:
Riliearch Dirlactor
I
4 June 1957
MEMORANDUM FOR: THE RECORD
SUBJECT F - Assignment of One IBM Electric_Type-
writer to MKULTRA Subproject 70
la One IBM electric typewriter, No. 151957 (reclaimed
from MKULTRA Subproject 57 upon its termination on 31 May
1957) has been assigned for use to MKULTRA Subproject No. 70.
AM.
� 2. Receipt ihereby acknowledged of one typewriter (IBM -
Electric) No. 151957on 1 June 1957. The typewriter will be physically
located inth
Branch II_
TSS/Chemical Division
Distribution:
Orig &2 - TSS/CD
^
�Nes
-
a
Ple
AV a :744
-
...., � ,......, .........,,,n�-����-� ...����� _... _
r4.5 i'P ".. '. '',' ..-1.���,"..S =.4,4
TV.. ,..e.,1 7-111 ' 1,1.:.;!7..:,) :::VCeD i
a 1.". '�'-':'4
...,,__,..,...., ......, , ,.... .., v� .
41,4 0.4,..:5 L 4:1$ al oa, VV4 4a �����!Li::0.� o L.
1 � ����,-.1, 34 '..15,..b : siti-S �,.i...,,, 4424-1 im: va,:: ;la
......�����m���.....,
4 - .....0. 10., SO 4.,... id, � �
I
I. i
� ..............re 1.�������-����=a���ili� ....D. -....... �������4 �,,�������*-4-��������,�,..����-
.
*eq. a**. ...,......... aer--t� .��������-� sor�-������.4. ����A- .......--����� ...............e. ��� en,..,--�� ar�mir.� * �����-.. �������-�.� ..�
-
-.1 "A471-4
1 0 � r
- � AP.edrAPkv..1 ��� M - w ff."1..
016P: int*
�57-4,.
� - �-��,��
Is. M. VW-TM-A. M 4.1
WV
-
/111. VOWS
-
S. �
-Wee, �rwa
�
1 May 1957
MEMORANDUM -FOR: TUB CO4rthoLvell
ATTENTION riaance
SUBJECII _ mKulanA-Subproject 70
Under the authority granted In the Memorandum dated
13 A ril 1953 from_the_DC1 to Mir DO/A and the extension of this
'authority in subsequent memoranda. Subipreject /0 has been sp..
proved and 249;152.43 a the over-all Project MKULTRA funds
.:YS beettobligated to cover the subproject'ilexpenses and should
be charged ta Allotment 74502440-001.
SG.
SIDNEY Giyrrutu
- Chief.
TSS/Chamical Division
'APPROVED F611-1)BLICATION
OF FUNDS:
- -
es;arch Director
IhK1.1\
Distribution:,
Ortg & 2 Addressee
- 1 - TSS/OC
,-.TSS-/FASB
1 �TSS/SRB
TSS/CD
(1 May 1957)
SUBJECT:
MKULTRA-Subproject 70
1. The purpose of Subproject 70 is to initiate research work
on the HICI(Knockout) Problem at the
.2. The scope of the research program is outlined in the
attached research proposal. There exists within the Agency a con-
tinuing requirement from the Operating Divisions for a substance or
substances_that will render an Individual or animal helpless and
immobile either consciously or unconsciously, until definite control
measures_can be institVitd,T-It is envisioned that this program will
-
supply some of the answers so sorely needed. A.% .
�;10.114* %mow
3._ It is expetted-th-at will monitor and
direct and actively partici ate in this proje'ot_as_principal investigator
from the
as an
where arran ements have been made for his appointment
� 4. In view of the magnitude and scope of the proct, it is
felt that a-t-wo-yeAr period is required for realization of some answers
to this intricate and complex problem. Therefore, a two-year re-
search proposal is attached. The cost of this program Is estimated
at $21,840.00 for the first year; $25, 422.00. for_the second year; for
a total of $47,262.00. To this sum must be added $1, 89048
repr s ntin a four percent service charge to the
making the total amount for two years $49,152.48,
The Foundation will function as cutout and cover for this grant. The
cover title of_the project i
MN* and is presumably being suppo t4:1 by a research grant from -
the Foundation.
5. The total cost of the project for a period of two years will
not exceed $49,152.48. Charges should be made against Alto rry�lerst
7-2502-10-001
116
D
by
011 67 -4115111rt
6. The Foundation has requested the University to submit
a summary accounting of monies received and to return any unex-
pended grant funds at the end of the project year.
7. Title to any permanent equipment purchased by funds
_ granted the Untversity-shaWb�ta1nedbj1hemth lieu of higher
overhead rates.
8. It was mutt.Tally agreed_that documentation and accounting
for travel expenses which are reimbursable by the University shall
conform with the accepted practices of that institution. _
9.� The requirement for a six months' informal accounting
on the part of the princl2a1 investigator is waived. �
10. is cleared through TOP-SECRET and is aware
of the true purposes of ihUprogram. Also, he_has_agreed to comply
with the-requiritnents of the Memorandum of Agreement,
Chief, _Bra�cbJl
TSS/Chemical Division
APPROVED�FOR�OBLIGATION Approved:
OF FUNDS__
Researc Director- TS eretcal Division
�r
Date: 1,57
Attached:
Research proposal
Distribution:
Original only
t
Jr' Ell.
1.1t11.:.rity
Juno j77
17.`Z":.Yr�":-
B
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I er; er, BY
here ex sts within the _Agency a continuing requirement from
the Operating Divisions for a substance or substances that will render
an individual or animal helpless and immobile, either consciously or
unconsciously, until definite control measures can be instituted. The
Instances and situations where such an advantage can be utilized are -
too numerous to be mentioned. Within TSSICD this problem has been
designated the "Kli (Knockout) Problem.
From various sources (scientific literature, TSS/CD projects,
etc.) numerous bits of disjointed information have been accumulated in - �
this area. Many provocative suggestions were raised that warrant -
further investigation. To date, there are no active projects or indivi-
duals specifically established by TSS/CD for the investigation of this
problern_. Therefore, this project was designed for the purposes of
centralizing all efforts in this field, consolidating the existing data,
and initiating active research on some of the many existing provocative
suggestions.
- - The project will be established within the
divided as follows:
_
Initially, the research activity will be
. Th-e-Experimental Evaluation of Sedative Agents
A. TicWParalysis
Certain species of ticks (genus Dermacentor) have been
incriminated in a clinical syndrome commonly referred to as "tick
paralysis". This syndrome occurs in both man-and animals. It
results from a tick bite, and is characterized brascending flaccid
paralysis of the musculature. Removal of the tick is usually followed
by complete_and rapias spontaneous recovery. Thiology of tick
paralysis remains obscure. The disease is believed to result from
the inoculation of some unidentified tick-generated, toxic substance
'which appears to be neurotropic.
As a by-product of Project Naomi, a sizeable amount of this
neurotropitoxisubstance is being isolated. The development and
experimental evaluation of this substance as a sedative agent will be
carried out within the scope of thi"K" Problem project.
. Downgraded to:=0001,-
by atithortCY.of:
: date: Juno 1977
'VZ MUT: CL BY
�
B. Narcotic Effect a Fatty Acids
As a result of preliminary investigations carried out within
MKULTRA Subproject 57 (terminated 31 May 1957), it was found that
the parenteral administration of fatty acids-induced-a state of uncon-
sciousness in small animals which when examined by_electroencephalo-
gram techniques turned out to be similar to ordinary_skep. The '
length of narcosis varied with the dose of the fatty acid administered.
Of extreme interest is the fact that fatty ac14s, unlike other narcotic
agents, are normal constituents of the diet and_body_tissues.
Investigation will be carried oUt on:
1. Mechanism of fatty acid narcosis-
� 2. Effective modes of administration other than
parenteral,ia. oral, respiratory, -
Additional fatty acids = short or tong chain,
saturated and unsaturated.
C. Assay of New Sedative Agents
_
The methods usually employed fc14-th6 assay of sedative drugs--
are not specifically directed toward the evaluation of sedative activity
although all methods utilize one or another of the characteristics of -
"sleep" as the criterion of effect. In the absence of a pharmacological
definition of sleep, evaluation of sedative action has been conducted
at different levels of this state, ranging from sleep itself to hypnosis,
and even to general anesthesia. It is apparent that theriteria or
endpoints employed in such evaluations have either overshot the target
of sedation_or_have not bracketed it adequately. This then leads to a
state of general confusion in the evaluation of the newer_sedative agents.
To utilize effedively the sedative agents available, both tested
and untested, requires the development of a systematic method of
testing and systematic method of characterizing the drug, both in
terms of the symptomatology produced and in terms of describing
potency in producing given effects by means of standardized and valid
statisticaiprticedures. An objective report will be designed that will
attempt to standardize the reporting procedure for all TSS/CD research
Downsraded to: COMM
by authority of:ANININRww,
do.te: JIM) 1977
E2 1.7Z:,; CT.,137
�-411
7-4
' �
'41,4
by .a4thority
datoi Jurie 1977 3
E2 11.2DET; Cl, BY
projects employing aninial experimental procedures.
IL Incapacitating Agents
-'.."1.061.210.111111W
26)"-
As a result of animal testing proceduresa number of
centrally acting skeletal muscle relaxants WZire be found. Several ---
are or have been evaluated clinically in man with varying results.
Occasionally,- cliriical reports appear claiming that certain pharrna
cological agents that have minimal muscle relaxant effects in some
experimental animal preparations produce drathattc_reitef of spasticity
in man, Clinical Impressions are the usual criteria of effectiveness. .
'There exists within the
the o ortunity_or clinical evaluations of
some centrally aitingikeletal muscle riraiiiitebiithe-therapeutic--
relief of spasticity in man.
(
rownsreded to: COIFICRIVAL
by authority of:
date: .711:::e 1977
E2 C7, LY
DorVad
� by a
!..t?Dra; cis BY
11
TIM
First year.
Neurophysiologist (M.D..)
�7--
�6,000.00
Research associate (Ph.D.)
4 000.00
Lab technician
3,000.00
Lab_assiliant and secretary
3,000.00
Equipment, apparatus
2,-501::c 00
Supplies, expendables
1,000.00
University overhead (14%)-
Second year
A
$19,500.00
2,340.00
$21,840.04
Neurophysiologlst (1k/I.D )
7,000.00
Rdearch associate (Ph.D. )
4,500.00
3;30000 -
Lab technician
Lab assistant and secretary
3,200.00
Equiptne-nt, apparatus, etc.
1,50G00
Supplies, expendables, animals
1,000.00
Animal keeper
1,80M0
$22,300.00
University overhead (14%)
3,122.00
$25,422.00
Doing -ed t. 6Ft6thT(AL
by thori. of: bOknntul.i--
d : 177
2: Cr3 B 1111110120.