MKULTRA SUBPROJECT 61 (57 DOCUMENTS WITH PUBDATES FROM 560622 TO 611120 )

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00017461
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 80
• Document Creation Date: September 25, 2024
• Document Release Date: September 8, 1976
• Publication Date: June 22, 1956

-
Purposes To study the role of the human brain in overall adaptive behavior.
Specifically, to show the relationship of changes in behavior due to stress
(mental disorders, sensory deprivation, peptic ulcers, threatening life
situations, etc.) to changes in behavior brouaht about by actual loss of
cerebral tistrue WCULTRA. 61)�
Initiated in 1956 as part of
t. Current research initia
as a grantee of
- Cost: 460,70/7. (Thi0 is the last year in vbich this activity will be
funded by the Agency,)
Status:
. �
vo
Cr="1
7olctims Table II
Tfic Boobs �
. -
S--4,t11,1 i
rrtif &Nadalteattmd
thMib1a 4.,r
 0.)rrec
Gentle
We are pleased to be able to transmit to you the following
funds:
177038
338,36,da ptedber 1 1960.
These funds represent a contribution for the use of your
directors in carrying out the very worthwhile reaearth goals of
your organisation.
Yours truly,
Encl.
Checks (2)
MOW= FORi FIRANCS DIV1
VIA
t TM/Budget Officer
SUBJSCT AOJtc%6I, 'Mice
Allotment Number 152 40094902.
1. Invoice A4,4 6 covering the above edhproject is
attached. Payment should be made 63 follows:
Cashier'
ble_
Cash%
able
drawn-
t of 58
--
amount co
f%
. Plca torwi the checks to Chief, TED Research
_ Branch through TSD/Zudget Officer, no later then Ihtursday,
8 September 1960.
3. This is a final illY0100. Weever, since it is
anticipatod that additional funds_vill be obligated 'for
this projeet, the files should not be closed. .
Attached:
Invoice & Certit1cattis
Distribution:
Orig & 2 - 1k4drea
CHECK T'
Igneo
tet_
ISD/Research Division
C RTIFY THAT rUNDS. ARE AVAIL-ASV(
CVAATIOrstuct.r.Na Nz. 4/7
CmokROF TO Atui.ro..INT
_
t.,v;;:::;UNT
Ears
MOWS
CERIVICATION8
(1) It is hereby certified that this is Invoice N. 6 applying to
Svbprojeet 61 of WULTRA, that perforoence is satisfactory, that
services are being accoeTlished in accordance vith mutual agree..
tents, that a detailed agenda of the payments and receipts is filed
in 2$D/R74 that this bill is just and correct and that payment thereof
has not yet been made,
Date:
(2) it Is hereby certified that this invoice applies to Subproject
61 under MKULTRA which VAS duly approvol and the project is being
ea/Tied out in accordance with the memorandum dated 13 April 1953
fro the DO/ to the DD/A, and the extension of this authority in
subsequent memoranda,
r
No. 4/7
Cost Account
Object Class
Date
3 1 1' 9u6S
Remarks and References
Obligations
Incurred
Obligations Unliquidated
Liquidated Balance
7 SEP � tat
t9eo
t�
fiff
ig�
wet 1960
14224C1VIDU4 tO1s OWTAOLLFA
Axlsorrou Finance Division
SUMO' s HOLM, Subproject 61
r the authority granted in the oran ated
13 Wit 1953 from the DOI to the DD/A, and the extension of
Ole authority in MAIMOTATA memoranda, Subproject 61 has been
approved and 460:79746 of the oYer-all MULTP,A project funds
hao been Obligated to cover the eUbproject's expensea. ,Thie
Obligation of funde should he charged to Allotment ty25.1o0-
19o2.
AV a OTtED Poit MUIR: ON OF
I CERTIFY THAT FUNDS ARE AVAILABLEI
OsucAnom FunENCE NQ. 4/7 _
P.99CE TO ALIO TMENT N.".010,2
AUThQZNG Cr)i.FICER
Dietribution;
Orig. & 2 - M4resee
For 12 Months: September 1, 1960 throuh Au
1 1961
Animals (Purchase $800; Maintenance $500)
$1300.00
Chemicals �
1700.00
Glassware and Apparatus
1150.00
Books
390.00
Apparatus for scanning EEG alpha waves for brain function studies
4290.00
Special Payments for Experimental Sublects
(for brain function studies) ,
1800.00
Overhead (approximately 6%)
(includes retirement and Social Security)
3329.00
Win; etZ
Salaries
echnician
icion)
e ary�typist
Biochemical Technician
Psychological Technician
Port-time Diener
$44,500.00
$ 58-74-0
1...�11^91111101111111.110.
L.:;=.1sra
ty
Oztc; 1:.77
; 137!7 .
F2 !CF)E7', CL BY 187475
1.4 ��� r
YZMORANDUM FOR TEE RECORD
SUBJECT: Continuation of Project MULTRA, Subproject 61
purposeof this Subproject is for support for one year
of Dr udies On the role of the human brain in
overall adaptive behavior. It has been shown that charges in behavior
due to various kinds of stress (sensory deprivation, threatening life
situations, mental dieorders, peptic ulcere, etc.) are comparable to
those behavioral changes 'which are brought about by actual loss of
cerebral tissue. In the course of this research new techniques of
measurement and new inetrumentation is being developed with appli-
cations in other areas of TSD nterests.
It is anticipated that this will be:Abe last year in which
this research activitywill,be funded by us.- Although several por-
tione of the work have been and will continue to be supported from
ether sources, it is felt that Dr. d his group can obtain
total research support for continuing work in this area from other
Government and private sources after this next year.
11 function as
cover and cutout for this project.�The attached proposal indicates a
cost of $58,459 for one year. To this must be added $2,338.36 whAch
represents the 4% service charge due to the cutout. The cost of the
project for one year will therefore not exceet $60,797.36. Charges
-
should be made against, -alio
spt _#1525-10094902.
:=12, 177
ill reque
Submit to them a summary accounting on an
annual basis of all, monies received from the Society. Also, it has
been requested that any unexpended funds be returned as soon as
possible upon the close of the grant year.
5. Title to any permanent equipment purchased by funds granted
the University shall be retained by the University in lieu of higher
overhead rates.
6. In connection with travel under this project, it is agreed
that the Agency will accept the_travel documentation and accounting
which conform with the practices or the University.
Chie
TSD/Research Branch
APPROVED FeR OBLIGATION 0f FUNDS:
Attached:
Proposal and Budget
Distribution:
�rig only.
-
F1oposed Activities from September 1 1960 through Au
y Grou
6
roc ton
The group will continue to investigate the role of.the central nervous syst
In human disease.
1. One branch of these activities will be concerned with extending and analyzing
phenomenon established In previous studies that the functional capacity of the central
nervous system is impaired following prolonged periods of kadequate and unsuccessful
adoptetion. Two projects will be carried out. The first is on extensive analysis and
comprehensive formulation of data already gotherecisin which the highest integrative function
of patients diagnosed as having chronic
and of patients with prolonged
and scve ere assessed. As the analysis proceeds additional psychological
tests and observations of such subjects will be required. The second is concerned with
the observation that subjects kit
as well as ostensibly
Intact patients'with prolonged on are defective In their capacity to
form "temporary cerebral, connections" or "conditioned reactions" as demonstrated by
the ciattrotncephaidoraph. Those observations will be extended to include hospitalized
patients with schizophrenic reactions, patients with lesions of the brain in regions
other than the cerebral hemispheres, and subjects who ore experiencing severe stress and/
or anxiety, especially in subjects who are adapil9g to a new environment.
2. Studies designed to examine the hypothesis that the mediator substance of axon
reflex vasodilatation (neurokin1n) is implicated In the mechanism of a variety of disease,
states.
-2-
a) it has been established that neurokinin Is present in Increased *moan in the
painful and tender regions of the scalp during vascular headache of the migraine type.
Further characterization of the pharmocodynarnic and biochemical features of this subcutaneous
perfusate will be carried out. Also, a laboratory rreathoci will be sought for screentng
of agents possibly useful in treatment of migraine headache, This method would be based �
on the potperties of agents that antagonize neurokinin or the neurokinin forming enzyme.
b) Attempts will be made to measure the neurokinin content of petM�s�
"washes" of abdominal viscera before-and during interviews dealing with aspects of the
patients' life situation that are particularly threatening. Patients-with colostomies Of
ileostomies with and withourWierattve colitis will be one group studied. Subcutaneous
perfusote of urticorious regions of skin will also be studied.
hemical and pharmacological studies of neurokinin will continue.
Methods are now being developed to prepare large quantities of neurokinin:
b) In cooperation with the Deportment of
characterization of neuroktnin will be attempted.
c) Phormatol:gical studies of the properties of neurokinin will be continued.
Preliminary studies have indicated that neurokinin is antagonized in vitro by the steroid
hormones of the adrenal cortex and by solicylote. This observation may be pertinent to
potification and chemical
the anti-inflammetocy Gotten of these agents. Studies of the action of these �gents on the
enzyme that forms neurokinin will be undertaken, Also it has been observed that LSD-25,
an agent that induces delirium when administered In extremely small amounts, strongly
potentiates one apparent action of neuraktnin (stimulation of respiration). Related substances
801, UML, do this to a lesser dcgree. These observations are porticutarly interesting
In view of our observation of the abnormally high levels of neurokintn-formIng enzyme in
cerebrospinal fluid collected from patients wi
Also, preliminary observations
of the behavior of unanesthetized cats receiving intraventicular Injections of neurokinin
suggest that a cototonic state Is Induced. These observations will be exten0dAn gn
attempt to gain additional background information to guide studies with human subjects -
concerning the role of neurokinin in the Impartment of the highest integrative functions
of thebt.oin observed 'n in those with tsychosis. Thus a number of agents will be examined
� In the s rch for antagonists and potentiators of nem-01(1(1in.
) A book le gth monograph, tentatively entitled
summarizing and reporting the previous activities of this
up will be prepared.
b) A revision of the be
under way by C,
Jw1517 6, 1960
Lear
er
Enclosed please-find our check in_the_amount of $14,614.75
_which rcpreents the third payment of the grant our
institution for work inunan Ecology directed by
SinccroVe
P�no.
September 30, 1959
- Enclosed please find our check in the amount of $9,614.73
which represents the second ayment of the grant made to your
17edic C.11 fo _work ' rected by Dr.-
Sincerely,
Erie.
July I, 1939
Er.cioled pla.ase find our ch8ck in the a4lo-unt-of $14,614.75
which rof:refAdnts the firA quarteriy of 't-1 t
made 4� !! 1.4- - College for work i rectod
: by 4.,
5inceroly,
nolo:vire -
Septeiber 19,. 1960
sum of
of tr.
with his p
Solit n
of the
Attached is the accounting for the period _J
through June 30, 1960. We forwarded directly t
3
9.00 and held back $5,000.00..
h o was des ous of having tr.
t. tr. as_retirpd_f
oil. He then becate
from the $5,000.00 in
5LVAMAR1 Of EXPENRIS ON
Total SGloolos loottodee *44101 payments
kritipono
4114.r.R441 Libra),
Wantlkselosx sustascatios Infamous)
Treve1-_,
Telephone
Matta**No
ii Divisicn
FOR FISCAL YEAR
231, S02. 66
1,122.54
14411.29
133.64
1, 203. U
415.53
10, 620.00
X11.33
5,024.91
Total Expeooilttets $51, 925. 76
impahl foo oat rot 44004 4,643.92
ORAND TOTAL
Moat Pesalved kola Seeloty tar the twoostlisstion
(Inelvaitkiv Waves oartliesi ellef ftets provlovs year)
TOO oltamss
Fres betanso
$54 Sfif.
56, 599. 64
3, 134.64
above the sum of $5,000.00 was paid directly to
n the form of salary in monthly installments during
Ths above accounting is a true statement of
expenses on the above ac AS showed to me
RECELFT _
I hereby acknowledge receipt of ,the following:
- check No. A222106 in_the amoimt of i 859OOd�iT:
ted A
Cost Account /40,
Object Class
Date
Remarks and References:
Obligations
- Incurred
Obligation
Liquidated
Unliquidated
Balance
7 JUL
-7,.195g
P) AUG
4zed
tro4.41-
Aco -"Po
_II NO. at
ISMORAND114 CH/HP, IFINANCH DIVISION
VIA
: TM/Budget Officer
11 Auguet 1959
MEC? MIURA, Subproject 61, Invoice 15
1. Invoice No, 5 for the above subproject is attached.
Peireent should be made as follows:
in tba amoUnt of 458 459.
to
2. Please forward check to Chief, TSS/Chenical Division
Through TSS/Dudget Officer by Friday, 21. August 1959.
�3. This is a final invoice. However, since it is. antici-
pated that additional funds will be obligated- for this project, the
files should not closed.
TSS/Chemical Diiision
13 1A9u5S
Invoice 4 Cetifitions
Distribution:
Orig & 2 Aiidrssee
FASB TSS
7f
-E -_E, ira �
4-0
eveif--
'MICE
For services
418, 459 .90
0ea flSees-S5eee.eae 000 000 000 000000 0 00000
CERTIFICATIONS
(1) It is herby certified that this is Invoice #5 applying to Sub.
project 61 of MuLTRA, that performance is satisfactory, that services
are being accomplished in accordance vith mutual agreements, that a
detailed agenda of the payments and receipts is on file in TSB/CD,
that this bill is just and correct and that payment thereof has not
yet been made.
Chief, /Ceicsl Division
Date I
(2) It is hereby_certified that this invoice applies to SubProiect 61
under MIURA which vas duly approved and that the project is being
carried out in_accordance with the memorandum dated 13 April 1953 from
the DCI to the DD/A, and the extension of this authority in eubaequent
memoranda.
-441
MEMORANDUM FOR: CQMPTROLLEF
ATTENTION : Finance Division
SUBJECT
lv 1
: MKULTRA. Subproject Additional
Authorisation WS
--
Under the authority granted in th memorandum dated
13 April 1953 from the DCI to the DD/A. and the extension of
this authority in subsequent memoranda, Subproject 61 has
been approved and $38.36080 of the over all MKULTRA project
funds has been obligated to cover the subproject' expenses. This
obligation of funds should be charged to Allotment 0525-1009-490Z.
APPROVED FOR OBLIGATION
OF FUNDS:
Resea ir
Date:
Distribution:
Orkg it = Addressee
TSS/C
1 - TSS/OC
1 TSS/FASB
Z -
hi
TSS/Chomical Division
29 June 1959
MEMORANDUM FOR:_COMPTROLLER
ATTENTION
SUBJECT
: Finance Division
: MKULTRA, Subproject 61, Additional
Authorisation #4
Under the authority granted in the memorandum dated
13 April 1953 from the DCI to the DID/A, and the extension of
this authority in subsequent memoranda, Subproject 61 has been
approved and $20,198.20 of the over-all MKULTRA project funds
has been obligated to cover the subproject's expenses. This
obligation of funds should be charged to Allotment 9-2502-75-902.
Chief
TSS/Chemical Division
APPROVED FOR�OBLIGATION
OF FUNDS:
Research Director
Data:
Distribution:
Orig & Z - Addressee
1 TSS MOO
1 -
2 - TS
TSS /CI)
Janua
9. 1959
Enclosed please find-our-check Irk the amount -of $14.614.73
which the third quarterly payment of t :ivo
to th. �l].ee to-support the work of Dr
5incerely.
Enc.
/5(
�
SUMMARY OF EXPENSES
Total Salaries thnuding special payments
Equipment
Supplies
Reference Library
Miscellaneous (Including malpractice insurance)
Travel
Rental charges f
Telephone
Administrative Fee
Amount obligated for unpaid _bills
Total Rxpendi n:res
958-59
03,217888
75.65
1,270.66
49.2o
273.12
779.36
9,790.00
298.60
2=87MZ---
Tot l expendltures 58,633.64
GRAND TOTAL
Free Balance.
ii74 gz�d WatitttA
fistofifillur05.
of
Ta/Chamteal Division
t.',Vefr,Ls--
$63,507.47
$64,459.00
951.53
Datoti
BUDGET
1959-1960
Salaries - 45,650.00
Retirement and Social Security 2/93440
Office amd TeChnital atones and materials 1,150.00
Travel and Meetings 500.00
15$ University Overhead 7,625.00
580459.00
TOTAL
Downgraded
by nut
Cate:,J
E2 'MET; CL
187475
NEMORANDUM R: THE RECORD
SUBJECT : Continuation of Project WUITRA,
Subproject 61
. 'Me purpose of thin subproject is the continued support of
tudies on brain damage in human beings. Work in
this field has made good progress during the past year. Highlights re-
lating to this are quantitative clinical demonstrations of a much more
precise nature than was ever before possible of the actual performance
deficit brought about by suppeession of the-activity of various areas
of the central nervous system. New methods of measurement-of-circulation
changes involving the use of implanted thermistors of a very-sensitive
type have served to reduce the uncertainty of many of the experiments in
this field of researCh.
2. During the coming year it is anticipated that many of the
investigative techniques worked out in the past will begin to show their
5
effects in terms of a vastly increased rate of significant data production.
3. This project has been-reviewed,andapproved by the -Board of
/0 Directors Of It should be noted that Dr ceives no (I,
stipend under the attached budget and that several portions of the work
to be coveted will be supported by other than government sources.
_4, The cost of the program for a period of one yeart starting_
1 Ji.11.1959 is estimated to be $58,459.00
U. be used as a cutout for transferring the money
the funds required for one year $20,198.20 is --
being obligated at this time. Charges should be made against Allotment 9-2502-
75-902. Remainder of funds revl be obli Avhen FY60 funds become
vailable.
:angrad.
.nuthl:qty o
11:ca
El VTDZT: 1Q7,4,70.
0
Dotngraded to;
by autno
-date: J-
E2 ILTDET; 76
on an annual basis -all monies redeived_f
been requested that any unexpended funds be returned as soon as possible
upon the close of the grant year.
Title to any permanent equipment parch& ed by funds granted
the University shellte retained by the University in lieu of higher over-
head rates.
7. In connection with travel under this project, it is agreed
that the Agency will accept the travel-documentation and_accounting which
conform with the practices_of_the_Univerdity.
APPROVED FOR OBLIGATION OF FUNDS:
Date:
Attachment:
Budget
Distribution:
Original only
Dormgradod, t
by authority of:
eat� : Ju
APPROVED FOR ADDITIONAL-APPROPRIATION?c-
OF $38,360.80.
E2 OnIT; CL BY 1274'A
irector,..
RECEIPT
I hereby acknowledged receipt of the following:
Cashier's Check #A203172, in he amount of 567. 96 dtaWa n
d ed Oc
Cashier's Check #A20317_4,_ithe_arn
payable t
22,891. 04 drawn on the f
dated October 9, 1958, ---
October 1958
MEMORANDUM FOR: CHIE FINANCE DIVISION
VIA
SUBJECT
18$/Bud
et Officer
t MKULTRA. Subproject 61, Invoice 14
Allotments 8-2502-10-001 and 9-2502-73-902
1, Invoice No. 4 for the above subproject is attached. Payment
hould be made as follows:
Two cashier's checks, one in the amount of $35.567.96, obligated
under this subproject during FY 59, and one in the amount of
$12.891.04 obi' t under this subproject Y 5 tit
Table
Z Pleas. forward the checks to Chief, TSS/Chemical Division
through TSS/Budget Officer by Friday, 10 October 1958.
3. This is a final invoice. However, since ills anticipated that
additional funds will be obligated for this projeci, the files should not be
closed.
Attachments:
Invoice It Certifications
Distribution;
Orig It a Addressee �
TTS
�TSS/ CD
At
cue(
Tssiatemical Division
Pt
1111.0
INVOICE --
58,459. 00
CERTIFICATIONS �
(1) 3 is hereby certified that this ie Invoice 14 applying to Subproject 61
of_ MKULTRA, that performance is satisfactory. that services are being
accomplished in accordance with mutual agreements, that a detailed agenda
of the payments and receipts is on file in TSS/CD, that this bill is just and
correct and that payment thereof has not yet been made.
Chief, TSS/Chemical Division
Date:
(Z) It is hereby certified that this invoice appliea to Subproject 61 under
MKULTRA which was duly approved and that the project is being carried
out in accordance with the memorandum dated 13 April 1953 from the DCI
to the DD/A, and the extension of this authority in subsequent memoranda.
Date:
Res
arch-Director
Enclosed pleas
$14.614.75 which reproz
the gmnt
of Dr
FrIC�
October 2, 1958
nd-our-cheok-in the amount of
econd-quarterly pa:meat of :
liege to suport, the work
Sincerely --
July ?. 1958
Enclosed please find our check in the amount of $)),61&.75
which rep irst quarterly payment of the grant
liege to suprort the work of Dr.
otal J-rant for the period July 1, 1958
30, ii59
- Sincerely;
No.
Cost Account
Object Class
Date
Remarks and References
Obligations Obligations
Incurred Liquidated
Unliquidated
Balance
J U L
1959 Zkieri( la;(
iq AUG -
w 195:i -64414�44. -
,
.40 /ICY
-ee",76 94
OCT
1958
...
1
I
A
1
July 1950
CONTTIVELSR
I Finance Diiisioa
ULTRA, SUbproject 61
. Under the authority granted 1n -the tomovaodUM dated
-11 1953 'WU the DCI to the DD/A, and the extention of
this authority in sUbsequett memoranda, Subproject 61 has been
approved and 435456746 of the over-all NOMA project funds
bee been ohlizated to cover the subprojoet'o-expenses. This
obligation of funds shoed be 0114111161 to_Allotteht 9-2502-10-001.� --
TION OF
cti
rector
Distr Butioet
Orig & 2 - AAdressee
CEkTiFY AT F,JNS ARE AVA1LA3LE:
-
MEMORANDUM FOR: CHIEF, FINANCE DIVISION
VIA : ?SS/Budget Officer
SUBJECT
2.4KULTRA, Subproject 61, Invoice 14
Allotments 8450240.001 and 9;250Z-75.90
I. Invoice No. 4 for the above_subproject is attached._ Payment
should be made as follows:
Two cashier's cheeks one in the amount of $35,567.96, obligated
under this subproject during FT 59, and one la the amount of
$22,891.04, obligated uader this subproject FT 58Iboth
drawaona ank a made a able
2. Please forward the checks to Chief, TSS/Chenalcal Division
through TSS/Budget Officer by Friday, 10 October 1938.
I. This is a final lavolce._However, since it is anticipated that
aadttionel funds will be obligated for this project, the files should not be
closed'.
GHEE-A-a
k
Attachments:
o
Invoice & Certifications
Distribution:
itg & 2 - Addressee�
R.EE:"
CHK54)42...4i,
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A
000131011AR
_Finance Division
XIMILTRAII3tibprOjobt 6i
30 June 1958
Undikr_the autherity granted. In the memorandum astei
13 April 1933 frock the DOI-te-the WA, and the extension of
thie authority in-subsectuent memoranda, Subfiroject 61 has_bsen
sPPrond erri "89144 or the over-all WILMA pro,leot fun- is
hes teen obii.gatedto *over the aubprojeatte mews. Thia
obligation ot_fuoitia be charged to-AllotMont,8-2502.10-001
AMOCO
-OBLIOA71011 Of roost_
rA
sd:
Date*
Beaten
., �
I C.SIZT;Fy AT
"Vee,
();LICA;i0N * 4
CF,AW:;E .570 -
- -
Dietributiorti -
Orig 6 2 Mt
MOMS
' _Sutiprejte
Mance Division
LI
tittly 19,0
Deder_the authority granted in the randuci_dats
13. April 19,3 frets the Dal to the DD/A, bud the WAVIISIon_of
thts authority subsequeut nenorando, Subproject 61 MI beta
approved sad $50,67,96 of-the over-all-MtutiVA protot Nide
Ina teen oblitatei to cover the subproject's espouses@ Tbi 3
oblivation of fende should be to Allotteut 9-2502,1040j.
-00140ATICei OF FLIMS;
Da
&march
Dietritfution;
Orig 2 Mares
1 - T
2 -
TS3
(30 June 1958)
-.....inumummximiniumpoor
Ammon - ri
vision
_14404TU Subproleal 61
4111114,
Mir1the authority &vatted In the reoureatun
13 1 19jtzoIt the WI tn. the NI% eta the extenetanor
thte utherity in beequent nenariniat SubprNeet 61 Ma he
swrovel and "4,e01404 of the over-ell NMI% proleat fun4e
has been obli4fatect to :cover the sub?raleatis (morsels Th10
oblisation.of Anti: shoal be oheres4 to Allottent 6i.t302-10-40/.
TIM
rate
DietributiOnt�
Orig& 2 - Ailinseas
�
RAPi
_
CL BY 187475 30 June 195
MEMORANDUM FORt THE RECORD
SUBJECT :Continuation-of Project MKULTRA� Subproject 61- �
C./
e-Of this subproject is the continued support_
of udies_on brain damp in-hUman beings. The
attac ed proposallou nea progress in this field toidate and indicates
the plans for_nev_Vork�to be done during the cominglyeari-: -In-general,
the current and future emphaais of-the program will:involve studiad-of
metabolic and_bitChemical Changes associated with -impaired brain function
related to Other_types-of brain damage than actual tissue _loss,_
revieved and apprevedl)y
Board of Directors- t should be noted that Dr
budget and thatiseveral=P _ ceives no stipendiUn the at
the work to be covered vill-ba Supported by-other ,than government sources
., 3. -Thecoat_of the program f
1 J 1958:4_ tirla �7458,459.00
I be use cu out fiitransfe
C Oney t
ment 9-2502-
, 4
has requeste
an annual b of a moniee ived f
� requested that_any_unexpended funds be ratu
the close of:the-grant-year.
harges should_be-made-against allot -
o submit
a-summary-accounti
so, it has been
pessiblaupon
5. Title to any permanent equipment purchased-by funds granted
the University_shall:he retained by the University in lieu of higher overhead
rates.
6.--_-_-_InIconnection with travel under this project, it is agreed that
the Agency.will_acCept_the travel documentation and accounting which conform _
with the practices of the_University.
FUNDS: T8S/Chemical Division
Date: ),,IC / AI. J3'
Attachlent: Proposal & Budget by authority_or: 187475
Distribution:
Original only
SUMMARY OF EXP
Total salaries
Special payrents (Dr
Special payments-(Dr
Equipment (Er
� Supplies
Supplies (
Reference Lltrary_( oject)
-MtaCellaTi0013
typewriter maintenance contract
Travel (
Travel (
Rental chargesEf
Telephone
AdminIstratlye'Fce
oject)
$77,602.44
519611,34
150.00
r6ject) 493.05
ncluding July 158)
Total expenditures
Amount obligated-for. tutpaid�bVils -(inclUding
security on_Phipps-Honse)
GRAND:DOTAL-T-
94.73--
11457040--
12AJLS.1,
$112)331.34 _
6.0'7'2.00
Overdraft
Unpaid bills serried forward to FY 1958-59 6,022,00
gr-leWSiinttliEeciai'AIIIAtt VIValttotor paymcnt. 1.416(.1,36
expenditures.
TSS/Chemical Division
$118,353134
$7,438,26: _
Janua2y=59.58--
to th
in
-Foes
.Business Manape
please find our check in the uctint=ef_t50,000.00
the e nd-half paynent of theL
support the work ef.
Sincerely,
Wove r 15, 1957
Lear
closed is thi Society's check in the amount_of_W#000.00.
Thi first half payment of t)e ve
support the work of
he second half payment vi1I
#
Enc.
CE IRT
I hereby acknowledge receipt of the following:
r's Check #A181201, in the amount, of
ier's Ck_i#A18120.0
7... payable t
op�. 00 drawn on the
ed N ber 8, 1957,
00.00 drawn on the
Nove ber 8, 1957,
Date: 13 November 1957
28 October 1957
MEMOR DUM OR: _CHIEF, FINANCE DIVISION
VIA: TSS/Budget Officer
SUBJECTS MKULTRA Subproject 61, Invoice N .
Allotment 8-25-02.10=001-.
1. Invoice No. 3 for the above subproject is attached.
Payment should be made as follows:
� Tivoicashior's chocks, one in the amount of $30, 000.00,
d one in the amount of $20,000. -thArawn_on a
an k. a abl�
2. Please forward the checks to Acting Chief, TSS/Chemial _
Division through TSS/Budget Officer by Friday, 8 November 1957.
3. This is a final invoice. A total of $50, 000. Q0 was obit'.
gated under this subproject during FY 58. However since-it is antic-L.
pated that additional funds will be obligatid for thie-project, the files
should not be closed.
Acting
TSS/Chernical Division
Attachments:
Invoice it_CertUtcattons
1.,Vribution:
rig & 2 - Addressee
1 sCoxnptroUezi
?
411) 44-e.
I / A 4: . e.73
0 ,
For servic
� ite# we sr � moo res *0..10
CERTIFICATIONSIIII
(1) It is hereby certified that this is LaVoie. No. 3 applying to Subproject
61 of MICULTRA, that performance has been satisfactory, that the serv.
ices have been accomplished in accordance with mutual agreements, that
a detailed agenda of the payments and receipts is on file in TSS/CD, that
this bill is just and correct and that payment thereof has not yet been _
made.
Acting,Chief, T$S/ChCinicat Divisio
Date:
(2) It is hereby certified that this invoice applies to Subproject 61
under IIKIILTRA_wbich_was_dufy approved-and that the project is _
being carried out in accordance with the memorandum date'
1-3 April 1953-frorn the DC1 to the DIVA, and the extension of this
authority in subsequent memoranda.
Date:
Research_Director
�
eif cezi.
0 -
ed.
CCT). CO
amr%=��oem%
OSSUCti Finstioo Division
Ma Subtirtloot 61
Water the authority grated In the aismortughla dated _ _ _
13 April-1953 from tho WI to tiWICVAI an& the extension -
of this_autliority in subsequent temoranial Subprojaot 61
has been approved -ancli-MOX,00 of the orarall WAILTRA
pxojest fails hae been obligated to cover the_evibProJect`o
expenses* - Thin_obligatiton ct rums sued be -ohnrgad- to
mutatentie4,724.0.on.
triatributiota
�rigI2ies
1 - TsSiw
1 - TWARB
a-A. ass/n.0
T88/CD
�79.�R
Study of Righost Integrative "unotionsi Progress Report, and Proposal
for Aba-IComing fear.
I, Present $tatus_of-the-Studyi
The in-mitigations afithe-hithest integrative-functiene are fundamentally-
aimed at increasing:oar-understanding of the ridnetiOnfrof the human cerebral
hemispheres in overall adaptive behayier;\ They:arose-cut of our laboratory
and clinical experience durini the past twenty years, and eapecially_out-of
our interest inith.T7pheneszene exhibited by-men_exposedito extremely-threaten-
ing life situstions; end they were initiated during .the period when we were
investigating the-Untoward_effeets of Communist police procedures.
The body of eV/dance ettumulated during theso-studieiAndioated_that_____ _
under extremely adverse circumstanoes-men-may develop symptoms clinically --
diffieult to distinguish ft674-tbow4 prod4Ced by grossLbraindamege or by
agents that impair oerebral-Metabolismi lack of diacrielnatiOnvp9oritelerance
of frustration, heightened suggettibility, illogical_thinini. breakdown of
defense mechanisms, mental olaudintldisorientation, and frank delirium.
The initial effoMa_te elucidate these phenomena began-several-years ago,
and have largely been brought to a conolusion durinuth�speet twelve months,
The firet_stekin this study was the systematic investigetion Of the
highest integrative functions of people vho_hadisufferod damage to their
cerebral hemispheres, the aMount and location of wh.eh vsa known as precisely -
as possible,- Daring the coarse of four years, 230 Suoh7people were otUdied.
In order to provide them with the widest poesible-Opportunity to expose
their defeats in function, many areas of their adaptive activity were explored,
both outside and vithin_the laboratory. Subjects were observed In tbetr_
performanoe on essay procedures, inclOdintsame that-axe-well knOWn
AS wellas others that were new devised. They were-exposed also to procedures
espieially designed to investiga � areas of bobovior sth as perseveration,
which were of special interest, In Addition to thief opoh-was atu410._
extensively by the usual clinical, neurological, and payohletrie Methods,
Finally, an extensivoirevieW was made of his life history-or-both befere-And
after his brain injury, with epeolal Attention to his performance in the more
complex area of his_lifmaidjustmenti-such as his capacity_to_deal-Wtth
the requirementt end_chillenges arising in his twill), and in bis work,
The second step in the investigation was a eleilar-study_ot Ostensibly
intact people with no _known gross-daemge-t0-their cerebral heblepheres. WO
groups of such people have been inveatigetedt 50 peciPewith_disorders such
as chronic anxiety, tension, depression, and schitophreniaimand-25 people
with bodily illnesses-such as peptic ulcer, ulcerativecelitie or alvelps
headaches.
findings to_datet -
ii'rom the integration of all of the data obtained fromrpeople with damage
to the cerebral hemIspheresljt has been poSsible-to deftne_some of the
adaptive functione-of_the_human that are primarilyeutlerved by the noopellium-.
These have been called _the "highest integrative functions" of the organise,
and they have been placed in four general categories, vial_
(e) The tntsot7teopellium enables a an to expreesihis-eppetites driv4so
and feelings in. a manner7appropriate to life in a complex society.
(b) It provides hitt With:mechaniee for theachisvement_otoocp 44:-
goals (learaln.gaereory. Iogtes etc.).
(c) It enables him -to Maintain a high:degree of-telortnoe fOr-fr4Stre-
tion and failure when confronted by conflioting drives' and _to recover promptl/
from the effects of frustration_and_failure when_they-pocur.--
����
11(d) It provides tax with_theapeoity to maintain effective end well.
eeduleted defense reactiene (i.e., repression, deettriel pretendineo
ittona1i-
tation, blaming, withdrawal, phantasy, depersonalization, ebeessive-eompulalve
behavior, and bodily reaction patterns involving tlimentetion, respiration,
metabolism, etc.).
Evidence from-tho_stuey ofethe_brain-damaged indicateseth tethesehighest
integrative functions are net leemlited within the hemispheres. :hey fell
off in a graded fashion dependent upon the amount of hemisphere_tiesue that is
lost, and without. regard to its location. Moreover, they fall off long before
less highly orgteized functions, such as simple memorY, the ability to
calculate, or the ability to carry out taeks of sole complexity learned prior
to the brain injury, are -lost.
ividence fro* the study of-the chronically anxious, tense depressed and
schizophrenic subjects inditetes that their highest integrative_fungtione,
as judged by theireparforeence on the tests tnd in their life adjueteent, falls
off in a manner not distinguishable from that of people whe have sustained
brain damage. They can, of course, be distinguished fro% people with gross
brainedtmtge by the_absence_of localizing neurological signs, and by the
intactness of somoLof_their_lass_complex functions; bet In their inability
to express their feelings appropriately, to-etilite theiregeeleachieving
104049.111313 offectivelyito tolerate frustration and failure, and to maintain
well-modulated defense reactions, they are indistinguishable from those who
have sustained direct damage to their brans. In matey inataeces-their
functions are impoired to a degree equivalent to that produced by a large loss
of hemisphere tissue (100 grams).
Similar degrees of iepairment of the highest integrative functions have
been found in people with disturbances of bodily adaptive reaction patterns
such as peptic ulcer, which are intiettely tied up with the general life
\ adjustment.
Mete two groupe-of chronically ill people, in shorti show manifestations
of an impairment of their-cerebral-hemispheres, 300auee some Of the disturbances
of these people ars transient, the impairment of their hemispheres ls to Nome
extent reversible and is eald to be functionalmi but since many of their
illnesses, like schizophrenie, ulcerative colitis, and ohronio psychonearoses,
and their accompanying failures of life adjustment, are notoriously unremitting,
It seems quite likely that some_of_these_peeple have In effect, a severe end
permanent impairment of their neopalliume
This evidenoe-of severe, and possibly permanent, impairment of the function
of the cerebral hemiepheres ralsed_the_question of whether other, and chemically
detectable, evidences of altered brain_metabolism_might be found in people In
whom, up to the present, only symptoms -of disturbed funotiwhad_been_described,
It seemed possible:that substancevessoolated_with_distUrbod_cerebral metebollsm
might appear in the spinal fluid, snd might be found there in people with-dis-
turbanota of cerebraI7funotion,_
Therefore, the-initial search_was_directad toWard_the detection, in the
spinal fluid, of substances_that_might be related to disturbed brain metabolism.:-
. This Investigation has been unexpectedly fruitful. 4y_exposing to beef
globulin spinal fluid taken from people with known damage to the cerebrum,
it has been shown that these spinal Maids contain a substance with the -char.
acteristics of an swap, which breaks down the globulin to a polypeptide,-- This polypeptids bat not been identified_chemioally, but in biological prepares
tions it has.meny of the_charaoteristios_of_a_polypeptide found in_blieter
fluid and other inflammatory_exudetes, which has been called mbradykinin",
This enzyme has been found to be present in the spinal fluids of 45 out
of 50 people with various forma of active brain damage,It has been found
also in the spinal fluids of 13 out of 15 people during attacks of vascular
headache. It has not been found in_the_spinal_fluida7ef 50 persons who
had no evidence of disease of the oentral nervous &piton It Wei tOtInd in thq
fluid of some persons who were experiencing much-stroes.
Of perhaps 'meatiest intereet, it has been found tn the spinal-fluids of
45 out of 50 people_with aotivo schizophrenia, blit witheout_other evidenee of
disesse.
Ye believe that the finding of this entymeliks substance and pelypeptide
under the oircumatences deaorlbed supports other evidence that matabolie-dit.i.
turbances occur In the brains-of people with headache and schizophrenia' e expeot
that the same substsnte will be found in the spthal fluids-of people-With other
chronic disturbances-of-their highest integrative functions.--
It Is well known_that procdund disturbances of the highest-intevativa_
functions, accompanied by pronounced disturbances of mood, thought, ond behavior,
My be produced in people 0y-exposing them to environments to which-they Ckri
make no reisquste sdaptstion, such ta concentration-camps, or prison procedures
aimod at Interrogation and indoctrination. Therefore, it teems ressonable to
infer that exposure to_suoh a situation In itself producee=an-lftPeirmont or
cerebral hemisphere-function; and that this impairment msy-sometimes be very
grave.
Proposal forAhe-Coming-Year:
1. monogrsph_tItled
is plannod for completion -during 1958. The major gosl-of_this_publlcation will
be to define the defects In highest level sdaptive oapaolty that-oocur with
disease of tho reopallium, and to illustrate-how Chess defeats ate similer to
those produced by prolonged existence In an unudapted state. It is intended that
the description of the oomponents of the highest integrative functions will be
cosprehensive eneuh tO take into account the various elements of diseases
oharaotocrized by prolonged-diaiturbtncee or nood, thought, Oid: -havicr.
This projeet will he Undertaken primarily -by .Pr tt #n editorial
setistant.
2. in order to assess-further the highest Integrative tunctIone_of t people= ----
with chronic illness net ostensibly involving the-central nonvousisysteni-a study
or A cirefully chosen grolp of young pesple-with-Clabetes Oollttus wil�o Under-
,.
taken. 1:'tsta with regard :to their health, personalities, and interaction with
their social onvirennent_will be tethered by rwbera ofthe ataffiunderithe
direction of sing methods similar to those used in th
study. "ucport for this investigative offort-in general it being sought -from
other sourees; but for-the_special psychological _testing needed_for_tbia allpe9t:
of it 4 fUli-tile ptychologiell teChnician and s psychologist will be required,
3:�The folican-,uply on the 11 likewiseTprovlde an7opportunity
for the study of theirhighost integrative funCtions, t6.3 an7eatimate-of_0740_
influence of their life_experiences upon this. The Methodswill_be these that
have been deacribedvmeet of the necessary data vro already available, -and only
-
& moderate amount of addltionaiTtestin need be done.
h. J!. similar stud',usIng a caretaly selected groopof worktng won,
largely homogeneous 1n -its composittoni-Will bo carried out! :Aecorda Of healtbi
attendance, and performanoe on the 10b, oovering period or-Mere:than twenty
years, are available for these won. Those to-te-tested will be seleoted to
inOlude some with recordsof-O4tstandlngly good health tnedperformance, some with
oatstandingly poor health-_end_perforeance, and sone Whose performance -was near
the radian in these resosots. A large part Of the-bost_ct_Ably.p;PiootA1149-
vi11 be borne by other
.
5. In order to make a-further assessment of th"-effebt of damage -to the
neopalliam upon general-heelth, a-Kroup of thirty "objecte. with focal removals
of seior and minor Portions_e_the_oerebral hemispheres will be exallned to 4acertain
the illness episode rate of thees_people before and after the damalie-was viatbine44
Interest wIll also tiei Centered on the manner in which thlodotage-to the cerebrum,
altered the indlvidualle perceptions of tha threate_anc_challenges presented te
him by his environment.
v. :ha 3tud1e3ofthe4roteolyt1e onzireas in spinal flaid_will be oantimied,
with t.nr..A, ia.41kIlate 6oui.si- --
a. c.eVeaokx-nt_of_a_silpleiredily repeatable method for _the
quantitative ustimltion_of_tbe prOteo4tic activity el: spinal :luid.__Ile_pressnt
btu-assay teohniclue -oxabersose_and_techni.,-Ially dentalding. A simple 2he.misal
'test 0$4:f be possiolo. if such_a_Astb.)d an_be_dovelopad, a_lsrge series oL-
meaeurementa_of proteblytIc actIviti 14. spinal :laic will-be-lndertt-.1kon uzang
species obt.e.ined eroltbe neurological se47licu_lci
Hospital and-possibly'AA-
. lhe ap2raisal-of-theistinificance of the ouservailon_thev_increased
amounts of proteolytio activity _are pese.lt in spinal fltadot sols_times and
in 30A0 people. -:-n�vspproach -to this proolen will os 1_4rouo aecertaininz-the
effect o: a sterilei inject-r.ele giant, In the for.
ohymotry-psin. The effeote_of_Intr44enO4A-,' intramatcUlar, end-Terhaps intratheoai.
inlectiOnS-of'this and-eirlltrielab4tanoeti after suitable prcceutiuns have :been
talcen to ascertain the safety _of swhprecodurea, will .Ce und4rtaXen in people: with nigraine he&laohe and ,-schisoprren1c.�
o. Phartacelogioal studies will be undertstIcen in orderto_estb.tsh
whethar or not the proteolytio
kinin libsratitc st,Lyms.
7. itietpts to dovelop- w:mothodsifer_the_study_pf:the-hiEbeet integretlye-
fanotloc,s will continuo; one method ncw beind-considered is that of condiUoning..
_obstArved 13 Identical with a--Known brcdy.
the alectreancephaloiraphio_reeponse in brain-damage4 persona.
8. rnvestigatione_of_the_looal oorabtal cixoulAtion win liVoywise be
continued.
3t1Dairf .-8tu4 of Vagbost Integrative Funottons
FT 1958-1959
Dlrfttor
hots
PhIslologlosVPsycholoilat
$11000
Masai Investigators 3euro1igist---
9,000
gssesrob Assistant
41400
Piphologlit
7000-
Teohnlolan .
3,800
Secretary
3,700
Typist
2,950
Iditoriml Militant (bait-MA)
1,700
5 Ratiri Planliand 24 300. see).
2034_
Pormardirit:Ifioo_Tquivaent. 750
ffIce snd Pithnl.421-30011as 1,000
Tiosvel and Mostings
tinlyeralty 'Ntirbiad,I5 1425_
$581459
Cate:-Jvme-1977 Oetob�sr 1957
-to pf-Dtr,
MOORAHDUK FOR: Tii iic6 CL-BY-187475
SUBJECT: : Continuation of Project MKULTRA Subproject 61
tfs
this subproject is the continued support of
es on 'brain damage inihmman_beings. The
ines progress in this fie/d_to_date_and_indicates
the plans for_new:work to be done during the coming ;rear. In general,
the current and fUture emphasis of the prop= villAilvolve_studof
metabolic-and biocbAmical changes associated with impaired:brain fun-
ction releted_to_other_types of brain damage thancaetual tissue loss.
roject was reviewed and approved by the Board of Direetors
t the meeting of 11 March 1957. - -that the
indicates an expenditure of $614605.00.
agieed tocehtein411,605.00 of this from other than ,Agencylover-
Lug our contributiOhlthereby-tb 450,000;00.
3.. The coot_of_tbe_program for a pe od one starting
0 1 July is estimated to be-450300N
it) the money_
allotment _8
1>-4eques submit to
an annual basis or an monies received. fr
requested-that_any_unexpended funds be ret
the close ofithe_grant year.
00 011
leo, it has been
_pOssible�Upon_
5. Titleito:any permanent equipment purchased by funds granted the
University_shall_be_retained,by the University ii_lieu-of_higher overhead
rates.
6. In connection with travel unaer this project, it is agreed that
the Agency wilt accept the travel-documentation aa-accounting which con-
form 'with the practices of the University.
Attechment:__Proposal & Budget
Distribution: Dovingrado to
Original Only - TSS/OD- by alAthoritY orI 18
' tot June 1977,31 137475
The investigations in Brain Funotion initiateden t
Program were based on the postulate that the-funotions-of the human brain and
poseibly itaatreeture may be damaged as a consequeece_ofprolonged stress.
_ _
This thesis is now tamest fully documented. Early tn-the studyvimpairment
of the higheatietegrative AU-lotions was-defieed through the elaboration of
methods for theestudy_orhighly seleeted subjeots vith_loss of known amounts
Of tissue frem_the cerebral hemispheres. These pereonsewere-studied by a large
aggregate of: quantitative behavioral indicators and by mane of exteneivel
information frometheir_faMilies and theie-esseolateee---/tivas then demonstrated
that the highest integrative fUnotions are impaired!to_a_degree closely linked
to the Mass of tie-6110_1*es, regardless of site, and in_a mannerdetermined
the subjectle_developient, previous life experience:and-prevailing high level
adaptive reections.
These methods were next applied to several greapseof_persoes_vho had
suffered prolonged stress. The evidence gathered indicates that the brain is
vulnerable vhen-severe threat is prolenged, end maybe_damaged when there is
a failure in high level edaptation for long pertedS. Those persons who perceived
themselves as-most threatenedpand vho exhibited the most_seriousabreactionss _
were those vho_wereemost_seeerely impaired in their highest integrative functions.
Such defects were-aometikee Major and in some instances incompletely reversible.
To explain such defects, a thesis currently entertained by the _laboratory is
that the observed dysfunction may he related to neurohumoral and biochemical
aspects of inappropriate and faulty metaboliam that are-capabae_of-investigation.
The program-for the current year will include extensive-further documenta-
tion of the above theeis with explorations Of the biologic mechanists behind
these damaging processes. It is hoped thatpby so doing, ways and msens of -
avoiding and eliminating the above desoribed abreactions v
The personne1 and equipment will re in the _sde The funds Involved at's
detilled on the attached sheet.
Dr,
Dr.
Dr.
Die.
141
Mis
Xis
Mis
-
project director
neurologists par time,
Mx:psychologist, rull time
neurologist, part time
psycholelitt, 581517
research asst.
Secretary -
technician
3I-pist �
Retire. and 20 Soc. Sec.--
Special Payments
-
General Supplies
Technical Equipment
Technical Supplies _
Miscellaneous
_Travel
Reference Library -
Statistical Servics3
Admin. Pee7 10,
Moo
Moo
4,000
4,750
6,000
3,00
3,400
47�40o
50,837
200
500
1'o0
300
100
750
1001-
2;14.0(1
36 9 187
$61,805
SUMMARY OF EXPENSES _O
OUNT. FOR FISCAL 1956.57
Ag9untsOblislZaAC)z_-FkX95_ti-V,
Equipment 399,55
Supplies 352.76
Reference Library 23.29_1_
Miscellaneous 120,09
Telephone, electricity & exterinator 190.79
Travel (including taxis)------
Eq
2,114.49
Supplies 2,534.46 .
Reference Library .
129415_
Miscellaneous (incl house -bill,
settlement with Mr 1practice (...,
insurance, install, nditioners,
and reprints AMA Neurc-&-Psych-.)
2,050.28
Salaries (includi Soci_Sec.- and 5% Retire.
Plan)
37803,68
Special payments
4,635.74
Utilities
869-.80_ _
Travel
11337.98
Administrativ4 Fee
=
Sup
Reference Library
Miscellaneous ,
Salaries (includ; Soc.
Plan) .
Special payments-
Travel
Administrative Fe
520.55-
24.86
57.99
nd-O-Retire.
45,120.02
285.41
435;18 -.
-
3.75
Rooms (for interpreter-&Anformants)350.00
-
Meals, Taxis & Misc._for'infcralants
1,165;00
Informant Fees ,
1,400.00
Reference Library
11,85
Salaries (includ. See, See. and 5% Retire.)
11,630.65
Special payments.
5400.98
'-
Travel 1 21,22�,
Rent f
Obligated for Administrative Fee -
Total unpaid bills (including security on
$1,402.90
54
063.43
48 � 485.96
19,983.45
_ 6t675,90_
Total
1111NOMPIIIIINNal
130,610.74.:
6,300.00
2.051,02_
$138,961,74
Receipt
Receipt is hereby acknowledged of the following fou
checks;
Treasu check No. 1-152550a-dated January 23, 1957
drawn on t
the amount o
Cashi -check No. Al 35 dated January 14, 1957,
drawn o
in the an
Offici check No. 209=271-130 dated nuary 14, 1957,
drawn � in the amount of
$10, 000.
Cashier' heck No. D1%439739, dated January 11, 1957-
drawns-pn th
the amount
Receipt
Receipt b hereby acknowledged of the following four
checks: -
Treasur I check No. 1- 2550,-d ted January 231
drawn on th
the amount o $6, 512,50.
. C
drawn on
In the amount Of $6, 512. 50.
Cashier
drawn on th
the amount_
dated Januar 14 1957,
209-271130, da ed J uary 14, 1957,
the amount of
1
MEMORA
Uhf-FOR: _CHIEF, FINANCE D
VIA: US/Budget Officer.
-
SUBJECT" 1,1KULTIla Subprojec
In4-o1eo No, 2, Allotment 6-2502-40-001
1, Invoice NO. 2 for the above subproject is attached.-- Pay -
inent should_bertnade as follows:
heck in the amount of $6,512.50, drawn on a
a
heck in the amount of _48, 5t2.50, drawn on a
-
k in the amount of $16, 030.00, drawn on a
nk,
In the amount of $10,000.00, drawn on a
ks sh-ould be made
2. Please forward the checks to Chief, TSS/Chernical Divi-
sion through- TSS/Budget Officer by Friday, ; 18 January 1657.
3. This is a final invoice. A total of $58,612.00 was obligated
under this subproject daring FY 56, ilowever-since it is anticipated
that additional funds will be obligated for this project, the files
should not be closed.
Attachments:
SIDNE'Y GOTTLIEB
ChiW,�TSS/Cliernical Division
Invoice-6 Certifications
Distribution:
Orig & 2 - Addressee
1 - Comptroller
�43 07,(0e
10-0_,I-17.1- �
a,,rdeo
HEMORATI R E CE I PT
eN,
TO:
FROM:,
. SUBJECT:
I hereby acknowledco.-.s
Please return signed_copyliesl of this receipt
To
FORM NO.
36� 65
MAR 1941
_
;
; /4, too
$/Z � s
RE OF
DATE RECEIVED
DATE
iiECEIPT
Receipt is hereby-acknowled d of the following cheek: _
Cashier's Cheek, No. M24715, datedDecemher 13 1936, in the
am lint of $19,537.00 vable
rawn o
For servic
CERTIFICATIONS
0.. MMMMM ..
(1) It is-hareby certified that this is Invoice 2 applying to Sub-
project 61 of MKULTRA, that performance has been satisfactory,
that the services_have_been accomplished in accordance with
mutual agreements, that a detailed agenda of the payments and
receiptsAs_on file in TSS/CD, that this bill is. just and correct and
that payment thereof has not yet been made. �
---------
Chief, TS/Chemical Division
Date:
(2) It is hereby_cel*tified that this invoice applies_to Subproject 61
under MKULTRA which_was_duly approved and that the project is _
being carried out, in accordance_with the roemorandum_dated
13 April 1953 from _the DCI to_the_DD/A, and the extension of_this
authority in subsequent memoranda.
Research Director
Date:
6 December 1056
MEMORANDUM FO CHIEPI-FINANCE DIVISION
VIA: ' TSS/Bud et Officer
SUBJECT: MKULTRA Subproject 61, Invo et 1
Allotment-6-2502-10-001
I. Invoice No. I is attached covering
Payment should be made as follows:
t?
above subyruject.
'hierti check t the amount o 19 $37.00-
ra on a
Li The check should be forwarded to Chief. TSS/Chemical
Division through TSS/Budget Officer1 no later than Thursday
1
13 December 1956. _Other invoices will follcTw.
SIDNEY corruEB
Chief
TSS/Chernical Division
Attachments:
Invoice and Certifications
Distribution:
Orig Addressee
1 - Comptroller
TSS/YASA3
2 -SS/�
TSS/CD
6 December 1956)
_ K
E
1 t b
� ew
INVOICE
Foie services $19,537.00
CERTIFICATIONS
(1) It is hereby_certifted_that thisis Invoice I applying to Sub-
project_61:of 1401KU1TRA, that performance has been satisfactory,
that the services_have_been accomplished in accordance with
mutual agreements, that a detailed agenda of the payments and
,receipts_is_on_filein_TSS/CD, that this bill is just and correct and
that payment thereoLhas not yet been made.
Date:
ClWrss- cheT�ZiTaTITTision
(2) It is_hereby certified that this invoice applies to Subproject 61
under MICULTRA whicwas duly approved and that the project
is being carried out in accordance with the rlaemorandum dated
13 April 1953 from the DCI to the DD/A, and the extension of this
authority in subsequent memoranda.
Research Director
Date:
Technical Etfuiproent
Travel
BUDGET:
Project Director
9, 000
Neurologist _
4, 000
Neurologist
4,000
Physiological Psychologist
8, 000
Neurologist
�
6,000
Lab Technician
3,200
Lab Technician
3, 000
Secretary
3,200
Two Typists (3, 000 each)
6, 000
Su�btotal
46, 400
Overhead @ 8_10 _3,112
50,112
7,500
1,000
GRAND_TOTAL___ $58, 612
22 June 1956
MEMORANDUM FOR: THE RECORD
SUBJECT MKULTRA, Subproject 61
,
L.3**
I. Subproject 61 is being initiated to sup ort amn
dies located at the
2. The scope of Dr ogram will encompass
the following phases (see a ta.che proposal for _detailed_
discussion):-
(a) To systematically collect and evaluate
current research on central nervous
system function and structure in-order
to understand better what types-of
research on nlodification-ancl. exploitation
of CNS function will be most productive.
(b) To assess th-e-elernents of frustration
adaptation by-studying the reactions of
(c)
brain damaged and norp-brair. damaged
individualto artificially_induced frustra-
tiOn designed as a prototype of certain
situations commonly encountered in
nature.
To evaluate these reactions to see to
what extent frustratiOn�adaptation can
be prevented, postponed, modified and
predicted.
D,Y7n3raded
Wauthorl-ty- of :-1.87476
�
(2)
0 0 trePes
3. The cost of the program for a period of one ,ear
une 1956 is es ted 12
t or r ng the mone
'harges should be made agains
has requ o them
mmary a 104i ! nnua asts of all monies -
received fro lso, it has been requested
that any unexpen e returned as soon as possible
upon the close of the grant year.
Title-to any permanent equipment purchased by
funds granted the University shall be retained_by the Uni-
versity in lieu of higher overhead rates.
6. In connection-with-travel under this project, it is
agreed that the Agency-will accept the travel documentation
and accounting which conform-With-the-practices of the
University.
APPROVED FOR
OBLIGA rtoN OF FUNDS:
Research ec or.
ktn,(Rv)
Attachment: Proposal & Budget
Distribution:
Original Only - !TSS/CD
APPROVED:
Chemical fr
� ...I...3
26 l'9u3se,`
e-E5c
I QS i
AVIP."4 111 Xel� 4.
oa
�--�
Aro 0- At. of,/
/rsifilo
3f; of.f. 00
,
14.2.401,
J -
$910747 00
 : Fins ttcet Diviston
IC? I hilKULTIIA, Subproject 41
Under the suthority granted in the memorandum
dated 13 April 1953 from the Del to the DD/A, and the
extension of this authority in subsequent memoranda,
Subproject 81 has been approved and 45 8,7619 . 00 of the
over-all MKULeTilkproject funds has been obligated to
cover the subproject's expenses. This obligation of
funde should_be_charged to Allotment 6-2502-19-OM.
A PPROVED-F0ii
OBLIGATION OV
UNDS: �
'Irig;nal signed by
Distribution:
Orig & 2 - Addressee
1 --TSS/C: 1 - TSS/FASB
1 - TSS/Siti3 2 - Tss/cD
TSS/CD
22 Jun 56)
Acting Chia
oa
I CERTIFY THAT FLINOS AR.E AvA,;LAal,C, ,26
0%cATiOr.
CHARGE TO ALLOTMeNt � /0 � Qv/
AQT!IORIZING OFFICER
c2c)./
a
4sca-/0-00/ lg. Co
15'7;2 l'14{49
s s 7 14
- � -
osi.c. ot seye,�1 ) L 0
1.0c! oi-oo
�-) 0 o ci 0 . 0 0
- _
�I c7 et- ---------
� .,
21..-C7-, 6\-6 .-5151awill"
4
7.7�60.re ves...�...aessne...
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