MKULTRA SUBPROJECT 109 (31 DOCUMENTS WITH PUBDATES FROM 600219 TO 65092 0)
Document Type:
Keywords:
Collection:
Document Number (FOIA) /ESDN (CREST):
00017365
Release Decision:
RIPPUB
Original Classification:
U
Document Page Count:
76
Document Creation Date:
August 23, 2024
Document Release Date:
September 8, 1976
Sequence Number:
Case Number:
Publication Date:
February 19, 1960
File:
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MKULTRA SUBPROJECT 109 ([8144432].pdf | 3.17 MB |
Body:
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BY INDIVIDUAL
SUBMITTED 61Y
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1 July 1960
1 October 1960 - TI
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1 April 1961
. Z70:00
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Project: Subprctject 109
Date Initiated: July 1960
Date Expires: November 1961
Aulds�curient year: $2.1. 923. 20
Purpose: To deltelop bioaesay andltartnacodynataia technique* in the
field of ensyrnologfrequired Wthe RB chemiaLagtat program,-
Status: Prelimiaary survey work IS latht yet completed since the program
is ouly ia ts eighth rocath,
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This 1e is to certify that I have received an acoounting for MUM_
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$210080413(4 This_aceounting is being retained in the-project file
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officer.
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the expenens-lieted-14-the aeocuatiNg were for the purposes-authOrised
in the approved-activity('
GA irif 1
Untitled from eeteresli
devigrelles led
kneteltitatian
Dear Dr.
In accordance:with the your grant to Dr. enclosed
in duplicate Is the final expenditure report.- -
This covers the peri,od September 1; 1963,, to August 31, 1965.
Vet- r
/07�
Project Titlow Th
Principal Investigator
.D.
Pro slow a ad of the Department,.
Pharmaceutical
and Vedieinal Chemistry.
College of Pharmacy
Unantumbered
Wane*
Dm t.; August 31T1965
�
!teak
agotareol. rEALEIALiak
Outstanding
bymenta Encumbrvis.�1-
PersoanaIs $ 2,114.25 $ 2,114.25 $ s OP $ .0.
Associated, AssiStanta:
Consultants
Supplits and Materials 3,052.44
3,052.44
.0-
.
.o.
.0.
EquipmeAt 11,544.79
11,544.79
Travel 1,470.96
1,470.96
Sub.Total 18,1827,44
4 isii81;44-4
o.
7% Personnel Budget;
To Corer Ret..SocaSce.._ 141-00
148.00
In..
in of Total Budget;
To Cover Indirect_COtts 2,749.56
4749.756
.
.0.
Total ,$ 21_0080.00
irdaTO
=
243620-4609a- The
to; t/cs ice
C/7 i- 7 - 3
C If 376 -o?
7-6-3
T1DIiriL
-Du
(56E Memo rm-
pip 2&- 63
/o7
/0,
Dear
"Witk.refeience-Lto7Your letter Of QCt_O'ber_
find enclOaed_acctiy of our report of A,
_
and copiles-ofik-Ortespondence from Dont6
If the bast's' fer_this_reiort is not correct or if you
de-
sire additional. information, please let me know.
-
Enclosure
NTEROFFICE_COMMNITION
-
Diitc../FJLU3iAXr-2�64_121t1�L
in accordance with_Docto r instructions (per
�
telephone: Thurtday_afterni� 31 Jan ar 63 I oho
like r � t_that you autait to -th
idditionai wawa. Biteuto gLtAltla-kep
n connection with the grant award anncanc
_10
jteport, LISAA1. &mit um, in
th the grant award announced_ln_Doctor__
ter of 10 Decetsber1962._
It is my underatar4ing that no other fiscal reports _need__
to be submitted.
9
To:
of the Monday
afternoon, 26.August 19.3, t e conten s of my memo1pf 26
February 1963 should be revised as follows:
Please submit to the
1. . 2WagailkumallEtkral Report,� datedil Se tember.
in_conn ion with the grant award.announce -------
-,�,�
- tor. -1.etttr.s.YE-6_11_01LembeXJ-9_61.--...� ..-----
II. Only one Terminal .1121.6 dated 1-AugusU1965 in
conneaTa7VorrEhe grant WWF4 announced .n
letter:of1101December 1962. idAVC.E # 3
It is my understandingthat no other fiscal reports_need t
be submitted.
AL:sh
cc Doan
Dr.
tho_tortas of your gritat via .
onclosod tn duplte4to to ttbe final
report for tbe grant period Devoe.1:41_1,
1961, to August 31, 1963.
/07-9
Project Title:
Principal Investigator:
by -t
at t
Budget Report o RsearebPe�j�
beeeAber 1, 1961 to August 31, 196
Ph.D., Professor and Head ef the_Department of
rmaceutieil and Medicinal Chemistry, College of Pharmacy,
Deter August 31, 1963
Item
Appropriation
Outstanding
Unemeumbered
Panisima_Kwantasti Balances
Personnel;
Associates, Assistanti-&-Conaultants
$ 4,420.36-
$ 4,420,36: $ $
Supplies and Materials
5,053.14
5,053.14
Equipment
1,316.63
7,316.63
.0.
Travel
1,230.88
1,230.88_
Subtotal:
4 18;021.01
$ _18,021.01
$- .0.
$ .0.
7% of PersonnelBudget; tp cover
309.43
309.43
.0-
.0.
Rat.. SO4. Se
/
15% of Entire Budget; to cover
2749.56
2,749.56
Indirect Costs
Total
$ 21,080.00
2 �080.00
-0.
10�640.aelidagair.1.41.1�41=-,-
I certify that t7ervint17 nr -!,!:,r!fils have bee!".
satisfactorily - -0 oxDenditures --
vere incurrctd en cffialAt
NO-
by the
at-th
Budget Rsnort on Research Project
rimorted
December 1y-1961-t May -31 -196.2*.
Project Title: The Synthesis and Diochelnolcal_vslUation of_Potehtial Psychopharr �logical=
Agents.
Principal Investigator:
Pharmacen
Pate: ItTay 31, 1962
Item
Professor
and-I'!edical_Chemistry,
and Heal of the Department-t-
College
of
Outstanding Unencumbered
Encumbrances
-_
-
--Paymnts
Balance --
� -
Personnel:
$ 71000 02--
Associates, Assistart & Consultants
$:-499.98_
_-0-
Supplies and Materials
3,890.44--
�1,749.30
33.50--:-
2,107.64
_Equipment
4,745.00
2-1146-�14__
2,4,29.81
169.05--
Travel
1,670.00 -
-0-
636.07
Subtotal:
$17,805.44
$2,I63,3l
93912-.78
00 -
450.00
7% of Personnel Budget; to cove
525,
35.o0
.0.1_
Ret.-Soc.See.-1n.
1,929.91
15% of Entire Budget; to cover
2,749.56
� 819.65
Indirect Costs
Total
$21 080 00
$6,2&.00
$2,463.31
$120337.69
io
Budget Report on-Research-Pteject
Su orted
ember 1,1961 to August 31,1963:
Project Title: The Synthesis and Biochemical EValuation of Potential_Psychopharmacological
_
Agents.
Principal Investigator: Ph.D., Proftsor-and-Head-of-the_Department of -
Pharmaceutics and Medicinal Chemistry, College of Pharmacy.
Date: August 31, 1963
Item
Outstanding --Unemcumbered
Encumbrances Balances
ApproiaaLlaa
--Payments
Personnel:
Associates, Assistants & Consultants
$ 4,420.36
$ 4,420.36
$ 0-
Supplies and Materials
5,053.14
5,053.14
Equipment
-0-
-0-
7,316.63
7,316.63
Travel
1,230.88
1,230.8_8
-0-
Subtotal:
$118,02401-
$-18,021.01
$ -0-
$ -0-
7% of Personnel Budget; toicover--
--------
309.43
309.43
Ret.- Soc. Sec. - -
2,749.56
2,749.56
15% of Entire Budget; to coveri
-0-
Indirect Costs
Total
t 24080.00
21,080,00
0 rt:
I-
Co-1/230.41
'7-1-
ii-zo- 01 I
'04PIDAZovet) bvileqc.et,
4:1) 680, err)
ALI; oFt so, try
c1S-6.-ro
AP PIZaeRL4ruml
PA YNICAITS
-
tn. a
54 4,. cry
.2-11 el,
2.5.2. 1-1 i
Igil. it 1
II
'IN1 080.
EAJCt.)Alt3
,c163.3/
ugavc
84 4
- 17, 2,i7.
MIS _
Datt_lt_rehniary_i_le
DERATIODAL-ACTITITIZE_SWORT
Bra rich__ BB , Catego Deh aviorantrol NaterialaL _Alfa
Synthesis and evaluation
of potential_psychophar-
Proj-t Title ma_4_ecfric_2__.0 kal COODOUnd. Item Classification
Project Crypto__,. NEM Cryptcl Classification____Unclassified_
Contract NoMTRA_11109
Type of Contract
Task No ��Ntrite
Date Initiated�Jigy�L980
CosL 1T43 11.92.1.2.0___ Completion Date_30_-_,Iune_1964
Purpose: Elucidation of interrelatiooships between molecular con-
stitution and biological response of chemical-Compounds of
interest to TSD.
Status:
Ternidia-puar-of a basic biochemicsi. research. All-bOt- the
Sinai phases of the research has beeh-completed-and-the-- --
reports subMitted. Reports relating to final-phases-of the
contract will-be received upon completion;
Requirement: kite-many generated in "MD by peed for_sPeeial-biolo-
ically_actiVO compounds and basic information of their
characterization.
Date
#60
REVISED
September 1963
BEHAVIORAL-ACTIVITIES SUPPORT
BranchBB Category Behavioral- Control Materials
Synthesis-and,evaltation (formerly Vb)
of potential-psychophar-
Project Title macological compounds Item Classificatio Unc1asified
Project Crypto
Branch Project No
MKULTRA
A.
Contractor_
Crypto Classification-Unclassified
�
Project Engineer
Contract No IIKULTRA # 109 Task No
Type of Contract__ 1", 1 July 1960
- Date Initiated
Cost
Purpose:
Status:
$211923.20
Completion Date_
301N_o_vember 1963
Elucidation of-interrelationships between_molecular con-
stitution and biological response-of chemical dotpounds of
� intPrest to TSD.
1
1
Terminal -year of a basic biochemical -.research.
Requirement: Internally generated in TSD by need for special biolog-
ically active compounds and basic information of their
characterization.
I have receivt-d the check f
thousand dollars) froth th-
Please accept my sincerest thanks.
By Air Mail
ThiS�is just a brief note to let you know-that
00 three
by .the
Beorton.Researeh Project
caMber 1, 1961t4 May 31, 1962
Project Title, The Synthesis and BiocheMical Evaluation of Potentia1_Payehopharmacological7
Agents.
Principal Investigators
Date, May 31, 1962'
Ph.D., Professor and Read of_theJDepartment of.
and Medical Chemistry, College of Phermacy.-i
Item -
�attending Unencumbered
--
prriatiort- Payments Encumbrances Balance
Personnel,
Associates, Assistant4LConsultante
$-7,500.00
$-499.98 -
$ 7,000.02
Supplies and Materials
:
3;890.44
_ _ 1,749.30_
2,107;64
Equipment
14,7145.00
2;146.14_ . 2,l29.61
169.05
Travel
1;670.00
636.07
1,933.93_ -0--
Subtotals
07,805.44
$5,42905 ____$.463.31
$ 9,912.78--
7% of Personnel Budgetvto_tover
490,00
525.00
35.00
.0.-
RetokSoceSCti-Ins� !
15% of Fntir4 Budget; t:coverii
2;7189.56
81945
1192901--
Indirect COsts
Iftiol�=6,1110.11..1.1ANII
omp.intaga0.01111.31P�
Total
f21,080.90
$6,284.90
$2,463.31
$12,332.69_
_
itt
RECEIPT
Receipt in hereby acinowled*Ufor the follaring, two checks:
Treanurnrs- check- No.
in the
Treasurer's - Check NcL
In
dated 27
ble
caiber 1962
SECRET
(When rifled in)
NAME OF ADVANCE
DATE
10 1962
AMOU24843.20 (IIIiwOJCHER
424080.00
NO. (finance us� onljt)
REQUEST FOR ADVANCE
December
329926-13Ft27 62
OF FUNDS
PAYABLE TO
See At-taebed Pant Inat.
ROOM 1! BUILDING TELEPHONE EXT.
.__:12.1._____i�Vaatoot�_28k3._____
PURPOSE
iikdIrapeee to PICOLTSA
for oda advance
Tbe check aboald
26 December
109 Inv. 3 for activity approved. by ACJITCD on k December
viii be in accordance vitb Attachment A of 142COLTRA Fiscal
be foritrarded to ISD/1110, tbroueb TSD/Bodget oNficeri, no later
2962.
1962. Account1.ng
Annex.
then
STATUS OF OUTSTANDING
1
ADVANCES
I okras thor f will fully � account
le* Or reporting poin:i�ta tad and
orir000xpOrofocIlbal000'O,Ifliaoihorilsoldoofoctioollfrou
for 04 � Advance bynubmiamion
by the due datechebked
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eforoualtere
better: In
otttOrr to effect
the
and selund of
event alloy failure
ofe 0 anent.
,otny unexpended
to Co ace:moot
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DATE
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IFUNDS ADVANCED1
1:
DATE
10 Dec. �10
SIGNATU
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1
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OF,
APPROVING
OFF
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,
, 1.144F-Anowled88
under I to be Used
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receipt
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of funde::in
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I II CERTIFY
FUNDS ARE AVAILABLE
S810.0.4
1-,6
MII,
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i/KI4:44
DATE ' ,
1 '
AMOUNTJ
OBLIGATION REFERENCE NO.
CHARGE ALLOTMENT NO. ,
CERTIFIED
FOR PAYMENT
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:7.".t
MEMORANDIALFOR : THE -RECORD
SUBJECT_ MKULTRA,- Saproject 109 .
/07--"C
DRAFT
15_NoveMber 1962
1,The purpose of-thiasubproject is to provide funds fOr
the continuation of a study Of potential psyd4opharMeco1ogical
agente-In particular, studies will t directed-to the elusidttion--- _I
of interrelationships between molecular-constitution and biological
response. Studies will-be conducted into the :biochemical charac-
teristiesof_tertain types of Chemical moietiesTwhich_are of:in-_ _
terest_to :TSD/5B in carrying out its program onAhe_development of
means to_control Hula Behavior.
2 The attadhed BVIdget indicates the extent of the inYc6ti',
gations-that vi11't4 carried out under the direction of Dr.
n facilities available at th-
funda-for_this_project vill-be transferred using the
as a cutout.
3,7-The�studies being carried out under this subproject-wre
originally planned to cover speriod-of approximately five years
Based upon the attached proposal. However, the_change in emphasis
/09
of the present TSD program requires_tbat these plans-be altered 7 -
considerablyThe-investigation has therefore agreed to pro-
duce as many actualTend-item:compoundeiat-possible during the
next year-and_also-to consider this us the final:year:of the
project� FOrthis reason the attached budgetlaas�been-scaled -
down gnal te of to421,080,00,_
The lowerfigure reflects mostly-lowered personnel -costs
occasioned by-the-siMpler developmental activities7now planned,
4. The cost of-this program for a periodct-one _
not exceedi$2406M0 tO-Which must be added tpie_four per Cent
fee toAhe
trig the total amount121,92Y20. .
Charges-shouldba-Made against Allotment No. 3125-13907390271-'
5;� The
submit to them a summary accountingon7Aniannual-basis
of all_monins-received-from the
be returned_by th
of thegrant:year._
6.__A requirement fora six months'-infOrmal accounting on
the part_orthe-principal investigator Is waived.
7. - Iti8not anticipated-that-any-permanent_equipment will
be needed-for_this program.
Also, unexpended funds %fill
as soon as possible -upon the close
8. In connection-vith travel under this project, it is
agreed th tatie Agency will accept travel documentation and
accounting which:Conform with the practices of the
9. It-is agreed that technica1-4�--eports reflecting the
progress_of the research-program-shall-be submitted at-mutually
acceptableA.nterwals.
10._ All personnel conve-cted with the planning_and mon-
itoring of_this program -possess TOP-SECRET-Agency security
approval.
11. This project will be unclassified afr�it leaves the
Attachmentl
Proposal & BUdget
Distribution. --
Original only
BIOLOGICAL BRANCH
P
3
BY TH
AT_THE
PROPOSED RESEARCH-PROJECT---.
PPORTED 7- -
ye
Ju
y , 1960)
Project Title: The_Synthesis and Biechemical Evaluation of I Potential Psychopharmaco-
logical Agents.
Principal investigator:
Ph.D., Professor and-Head of the Department -
-Pharmaceu teal and Medicinal Chemistry, College of Phar-
macy.*
For the past several_yeara;_theTapplicant has-beetkengaged'in-research-involving--
(I) the synthesis of=organic-entities having potential effects upon the central ner-
vous system, and (II)-the evaluation of connections between-the-CheMiCalvand-pharMa--i
codynamic properties�of�theteaf4Oundhe-applicant is primartly-interested-in _
the fundamental studyoffreltibnahipabetween molecular constitution and biochemi'
cal response, and isparticularly-ooncerned with theeffeCtof=gradmal Changes_01�
the chemical structure-of-tynthetlo-entities:upon isolated t' ste s . e rea-
d referred to .(A)_reports_aubmitted earlier to the
and (B) publiShed accounts 849 for supplemental inforMation.
..
The applicant plansto_conttnue hia-iffiestigation in accordance-with-the princiPles
set forth in the citeditommunications. Specifically, he intends-to:
1. Synthesize severaLiii�of-new compounds patterned afteri(a)nrganic amines
known to affect=the_central nervous system,_and_(�) _moieties-acknowledged as sub-
strates in enzymeTsystems-implicated-in7the pharmacodynamics_oVcompoundslposAes'!____
sing psychopharmacologiCal-properties. The member compoundi-of-each series will
be designed withfgradual changes in-theit-conatitution, or-physical properties, -
or both; furthermoreitheyiwill-be planned in such a mannerthat potential diffe-
rences in the interaction between the member compounds of a given-synthetie-Serftl-----
and a given enzyme-Allay be-interpreted in terms of concepts reasonably well estab-
lished in contemporary theoretical chemittry.---
2. Study the effect:_ofthett-entitiea-OpOn'(a)-iSolated enzyme7preparatiowbelieVed: _
to be associatedWith_brain-funetien,-And (b) other-plausiblehlochemical systems.
3. Explore relationships between-the biochemical activity-of each series of derivatives,
and the successivechanzes in the physical _characteristics of the
member compounds.
At present, our synthetic work-is-Centered-around series-of arylalkylaminoalkylacete..."
mides, and pyridine�and_piperldinecarboxamides which _could be visualized-aa-moieties----
derived from the psychotomimeticrtelecule LSD (see Figures I,II, III and IV; other
series have been planned).
Concurrently, the completed compounds are being evaluated in isolated cholinesterase
systems in which LSD has shown-remarkable specificity. Our manometric-procedures
* Effective July 1,--1960 (on-leave-of absence July 1,1960 through-June-30 1961).
Page 'INK.
LSD:
RN
.�"
1. A
\"!
LSD:
of�
N
�C H
26
/
CH
CH-3
A
FTGURE I.
. 0
U C
-C2H5
/ 2_-
SUBST I
TUTED ARYLALKYLAMINOPROPIONA
,C2N5
C.41
3
0
)4N5
c-041F1
1
* I
I c
113C. N
71
0
N211
GA-93
NC2h5
LSD
CH30
CH
ON
IDE ANALOGUES
0
0 /c015
C -0 -N..,
11 "s1C2N5
C
/,
1,11
N �104
1
CH3
PI CO
C
11303
N3C0
N3C0
H3C0
GA-143
GA�I65
e.
Page Four.
...'����-� St --.40
2ip
-
I a,
I��VS F---k--. a .Y.
la do
1 t �
-V V
- �.t. I .41 V-IT---
I� 4
� 4.. � I :1)th 1
*
1
1
LLI
41,-*Z.���
/ P-
Page Five
0-H
II I
C-N-CH
N
CH
FIGURE7TY.
CH3
ces
Ceis
/oP.
MY-76
Page Six
yield very precise measurements of activity-in isolated pseudo- and acetylcholines-
terase systems, and enable-usitoevaluate the significance of even-minor variations
in activity due to small constitutional-Changes in -A aries-0Oleedles.
_
We are aware of the fatt-that-the-_effectiveness-of-a-psychopharmacological-agent-in _
vitro cannot be interpreted as evidence for the inVelvement oLth_emspecific enzyme
in the mechanism of psychotomimetic-responses. Yet even without conclusive causal- -
connection, this approach may furnith-va-1U-able informatiOn-66 the nature of-17,sychoa-
pharmacological agents ------==
* * *
It is felt that this investigation may yield (a) information assis_t_ing-the eludida-
tion of interrelationshipSibetWeen_molecular constitution and biological _response,
(b) better insight intothe biocheMical ch-gteristics-and therakeutic_poten_tiali-
ties of certain typeSofmoi-ec) several series of new organie7compounds.-4nd
information about their_phytical CharaCteristics, and (d)-datas_upplement_ing'Our:
knowledge of the neurochemical processes-associated-With-thtactiontoftpsychOpli-arma-
cological agents.
* * *
The references cited in-the-first paragraph of the outline areliated_on the ---
ing page.
January 22, 1960
cc:
701-
Page Seyen
. ^
-1. First Annual-Re tt to th
June 1955,
2.
3.
8.
9.
10.
11.
12.
13.
14.
15
16
19.
Third Report
to_the
in preparation
em er
May 195
Second
ecember 1956
Fou R.ort to the
y 1959
Nay 196
eve to the
. Chem., 21: 799, 1956..
Org. Chem., 21: 805, 1956.
J. Org. Chem., 21: 958, 1956.
J. Org. Chem., 22: 837, .1957.
J. Org. Chem.
�
23: .1577, 1958.
J. Org. - Chem. , - 23: -2005, 1958.�
MarAssoc.) Sci. Ed
Abstracts, Am. Soci-Pharmacol.
Nature, 184:1922, 1959.,
astry, J. mcd. pharmi-Chem.4 in press,
med. pharm. Chem. : in press,-1960.
/
�
PROPOSED -BUDGET-FOR-RESEARCH PROJECT:
BY THE
AT
(Dece
roug ovem
, 19
Project Title: The_Synthests and Biochemical Evaluation. of Potential
Psychopharmacological Agents.
Principal Investigator:
.D., Professor -and Chairman
0 the epartment of Pharmaceutical and Medi-
cinal-Chem-i-stry, College of-Phermacy._______
Personnel (Associates,_Assistants and Consultants) .
Supplies and Materials
Travel
SUBTOTAL I
7% of Personnel Budget ($�0Oiito cover
retirement, etc.
$: 1.2l000.00
$. e90.44if
$ 600.00
$ 3.711496:414-
SUBTOTAL II $ 18,330.44
_
15% of Subtotal II ($ 18�.330.114
participation in indirect costs
o cover
$i--7 2,714.56.
.TOTAL $ 4,080.00
* * *
Checks should be payable to the
May ii, 1962
/c1-= /v.
Date-
Vareaber
Branch__ Category_Segivitn Predi-Maa andCO4tt (V )
fiyatheal uatioa of Pettattial Payel2i0asteswLagiall. CoVeugulli
Project Title Item Classification___Aboummitruptl_____
Project CtyptoMISRA
Branch Project No
Cr-ypto.ClasstficationalThid___
Preject 'Br�cgincer__
I
Contract _ T1 No
Type of Contract-444.
Purposl:
Status:
--
1
Dat& IrUtiatec
5.11:
421AblY11 Con�ipletion Date1
altict4ation or lawrrelaticosbiporaittltion- toolftular tonstitutica
Vial leal-4-aiipctits-af�abrateal, 0040414 of Atitareat W TEO.
1
BMWS
interestly jtrsted in Tee by Seed for. sLul bialoi; rally
aetive eaarvourode azd Ir4ers/m.14* aa their chataatetaltation.
Dear
I certainly_enjoyad'talking to you this morning.
For yOunconvenience, 1 am-enclosing -Copy_-of_the
proposed_budget for_the next grant pCriod_(December
I, I962�th-rough-November 30, 1963).
With the very best regards,
Enclosure
By Air Mail
P.S.: My home address is:
1862 AMERICA'S LAND-GRANT UNIVERSITIES CELEBRATE A CENTURY OF-SERVICE 1962
TO THE
(Deoe er 30-19
Ph1,1).-,.Professor and Chairman of -
e epartment Of'Pharmaceutical and Medicinal
Chemistry, College-..0f=Phtmaty
* * *
May 31, 1962
$ 3,000.00
41)
PROPOSAL FOR ESTABLISIDH,NT OF_FACILITIES-FOR :PSYOBCrTO14ThTWDRUQ TEST
First Year:
fal=m1m�
Literature revielf-
SuveyotpQmiairg MOS �
Iris' to sourceseminars
suggestions
'Practice" trialsreproduce-established results
Effects to be-screened:-
convulsante --anticonvulsants
specific -arterial_d ilators - cons tritor s antiserotonin _effect
cholinesterase-inhibitors
BUDOET,-DIITIAL STAFF
Neurologist -r-incipal_investtga,tor
$ 3,000
Clinical pharmacologist
111,000
Research assistants
10,000
Statistician services (part time) - ---
1,200
Resident assi,nments(ELrio.-$300/ino.)
.
2,1400
F,quipment and supolies _
e.g. calculator, camera,
EalsCr� service, computor service 4,000
Travel 600_
To-t41 $35,200
To the budget figures must-be-added 7% of personnel budget for retire-
ment and 15% of overall costs-for overhead.-
/07-4
FACILITIES FOR-PSYCFMONDIETIC DRM TESTING (CONTINUED
Second Year:
.Glikalmelk�amB
Trials_cfr com ounds
Screening potentially valuable effects
Chronic toxicity in_antr,als
Human trials - double blind-and/or concurrent tria16f-
psychological effects
autodomic7effects
anticonvulsant --------
entispasmodid
anticholinesterase (liMited, on myasthenia gravis-patients)
antiserotonin-('olustern headaches)
BUDGET - &MOND-YEAR STAFF
Neurologist - principarinvestigator
$1;000
14;000._�_
Clinical pharmac-ologit_ __
Experimental OsycholOgist
10p00
Research assistants-- -----
10;500
Statistician services-
1;200
3,000
Clerk-statistdeian
Resident _assignments
3,600
5,000
Equipment and suppl a'(including animals and care)
Travel
1400'-
(+-7% personnel for retirement)
(+15%7overal1 for overhead):
It may be advisable_alsoito-consider the addition of a bas c7pharma4-,
cologist to the staff_in second (or third) year.
Attentiu
Deer Sir t
Mar ch_9, -1962 =-__ _
Enclosed-is7the- cumulative annual expenditure report -
on your_Drant_to Pr. This is for the period
July 1, 1960, to r!Ov?-..r 30,,61
Yoursvery truly,
1862 AMERICA'S
ND-GRANT UNIVERSITIES -CELEBRATE A-CENTURY OF SERVICE 1962
(Ju1y_1,:1960 throu9h-Novembe_r730, 1960
Project Title: The Synthesis-and-Biochemical-Evaluation-of-Petential Psychoph macologicalt
Agents
Principal investigator:
Ph.D., Professor and Head fJtherDepartmentIofii
f
?harrnaceutical and_MedidihalZChemistry,-College of Pharmacy
Date: November 30, 1961 _
Outstanding_Unencumbered
Item _ Aocropri-atien-Pa -ments=_Ercumbrances._
Balance
Personnel:
Principal Investigator $ 3,000.00 $ 3,000.00
$ -0-
-0-
0
0-
Associates, Assistants &Consultants---
1,077;00-- 1_1077-.00
-- - -0-
-0--
Supplies and D,laterials
77,061.55 7,061.55-
Equipment
6,324.-93-6,32,4-.93
-0-
-0-------
Travel
581-.57 - 581.57
-0-
-0-
Subtotal:
$18,SY15,05 $18,045-.05
$
285.39 - 285.39-
-0
-0-
77; of Personnel Budget; to cover
Ret.-Soc.Sec.-Ins.
15% of Entire Budget; to ;cover
�� � -0-
Indirect Costs
Total:
$21 080.00 $2-1-.080.00
$-0-
I have exad d apn1v=!.,3. the submit
expenditure:,
SiCliznioal
Date:
NV, i
29 March 1962
MEMORANDUM FOR: The Record
7-.
SUBJECT_ : MKULTRA, Subproject 109, Cost of
Equipment Exceeded Budget-Estimate
11The BI.Tdget Proposal for Subproject 109, dated
22 January 1960, had a proposed figure of $5, 000.100:for
supplies_a.m1 materials . There was no anticipation of any
equipment
2-. An accounting report has been received for the
period_1_In1y_1960 through 30 November 1961. This report
reflected expenditures of-$7, 06155 for supplies-and materials,
and $6, 32493 for equipment. These amounts-exceeded the
figures in the original proposed bUdget.
3. This equipment was expendable and the_expendiIII
-
tures have-the approval of-TSD/RB as being essential for
the successful completion of the research work-that was
conducted.
March_9, 1062
Dear Sir I--
Enolosed_is the
on your grant�to CP.
July 11 1960i-to Nove
nual expenditurirreport
This is for. the period
Cost�Aceburit I/ /0 � - �
Object Class �
Date
Remarks:And ReferenceS
Obligations= Obligations Unliquidated
Incurred Liquidated Balance
15'31
166V;
tol
u�lie
04346
,c4f/e a
Date:
MEttIORANDUM FOR; 'T.. C0141-:_)TROLLER
ATTENTION Finante Miele
SUBJECT ; IVIKULTRI Subprolect
Uncler th�e authority graritf.,..d ri-lernorau:lure. ad 13 April 1953 _
from the Doi to the OD/A, and tho tensiGn of tbio authority in oubsequ
memoranda, Subproject_i1
hag be aoprovocA, and $25, 043. 20
of the ovz.,,r-c,-,11 Projet t ivf:t:ULTEtA-funds havii beeii_:-.1bligo`,,ted to cover -the
subproject 'ae puics anci sho-orLbe_chargee to cost. ce,rit _ 2125.1311�322a ,
APPROTED FOR OBLIGATJON
OF FUNDS:
Re:Ilezrch ihreztor
Date.;
Digtribtlti
OriginZ1 Addrease T.
-=TSD/FASS
TSD/RB
MEMOAANDUM 0 chia.- nCe DLitt
VIA
SUBIECT
13_11ovetnbs r 1941
TSD/1144iat Officer
MKULTRA,-SarprOject 14)9, Iwo
Aliottneiit No.-212543901.3902.--
/0
L ktvolcizto. 1 cayering thc above fubproject la attache
Payenoat s mad be, (:).14,2- u (0114./WC
Casblerti_
drawn_
Ca
12
tof-SZ.1 08 .01. .
atnatuat o 63 2 dravia
yable to
Pleaforwari the c ecks , 'Lli;Dhles *arch
Branch throtqh TSD/Blidget Officer by 28 Novcntbcr 1961.
3. This is a final invOiCe. However, nce it is aatiatpatod
that adtittionat_inada will b4 -obligated for this projectl- the files
ehould not be closed.
Attachfr.ent:
Iavoice Ii' ens
Distrit.-mtioa;
Orig. k � Addressee
TSD/FASS
� 770 Z. g TSD/R.B
RECEIPT
Receipt is hereby_acknowledsed for_thefollowing two checks:
/0
Casbierge_Check-NOr. �ated November
e siountof- payable t
on
NaTne
ate
),IEMOWIDUM Chief,
VIA
?SO/Budget Officer
rcibe I
/07--- 2-
SUBJECT I _ MIcULTR.Subproject 109, Invoice No.
Allotment No. 2125.1390-3902,
1. lavotce No. 1 coverIa, the ab.oio etibpoject i attacbed.
Pay oat should be made as follows:
Cashier's check In amount of $24,0 00)
drawl
Ca shier 's
2�__Piesse forward the ch eke te Chief, 'ND/Research
Branch throtigh T813/13U4set Officer by 28 November_l96L__
1, This is a final invoice. However, since it is anticipated
that additional Ands veill be_obliaated for this project the files
should nOt be closed.
TSD/itsecarch Brita
Attachment:
Invoice te Certifications
Distributiont
Ori Z � Achit4esott
j TSD/FASS
=-TSD/Ril
/07- 2.3
1NVOIC
CEIV ..TICATIONS
11) hti41); thag th-;.5 ;Iftvetp_, 11-1' g
S4Ab=p7t03t.t N. 109 k NIKULTRATINd-pezicitxtvkatt iFvt.ti*Lattue _
tti?7,t alt:-.tonp24.41:htP-1 ,I,uc-c.rd41.4.coT with rsloaKA1
tit,t411.7td. 32endA 11.!v prAyt1ent4 464d res;,cipt,s c.,-n fill
%;�ti hill isj&i d4:-..c.xrect A.3.0 Atvt;i: spiwavott that - _
A4 Zoffi yet
ISO/RtIoe4rce.tz Bruxh,
004
113 November 1961
tvert,,by ..certlite4 tkAt thi.i invtqcoppii4 ta Slibuivolttt
wiKis:4A '41+6. duly apprcv-ttis. ..4114:1 that the: project it brAng
titd 4.:�?-atel.aaii_Ie with tfw rnecoc�rmd5.ttn tl 13 April 1953 from
18-,5 01)1A., &pd tht., extm,Ivicra