$36,800.00 P- 1,000.00, $37,800.00 2,950.00; 3 14.66,64 .4111t,216, SALARIES & FEES AND SOCIAL S CURITis Salaries and Fees Social Security SUPPLIES AND SERVICES: Speclal Chemical:it TOTAL EXPENDITURES RES CR GRANTS; SALARIES FEES AND SOCIAL fiEdDEITI4 Salaries and Fees Social Security TOTAL EXPENDITURES 61, vvv 4 01 h. ' l't. I f 4 � r% ,16ti 'A. A A AallANAI WT. AAA A t .1 ..0.1o4...14,14.11,444re' * *1,4 vtA ' t I; 4.4011,40.41. / kv., r f 1*,01 Vs* 1 V'It4.1' *V44111 04.1.4,1',.#.0.4.0.4.4* AbAlaika-M4A 101.11.4Ali 0.14S000,04,0 Cs 4 s-Se, � 01,4111. A litst4M-4 sese-airibispeokith ,,ottvot,e,v4..ft rtle ;ArIPV 4' 4 " el4 P�A*4.14,�.;14.�41r4ok 114.#10.100, VV.+ eiv.v,f1 ir lots 1,101,,, vet ;log. .1aVyief � � I � � * � � e I I * � � � � � � th , � � � � ..411 A .�4�1 MONA ql = .4404. 144 +1, v;t1� 1101,1.All AA/VAL 1A .-rr 7. sierrrirsol,r, � 1,55 as � ,tv,.gravertoiri+rirvrr'ni 1111/rr "ammo 7 1:1)t ) - 4.4 194,0., � KS, 4.- , � � � � � � a II I i .-*�.41�441. i 1' a i � I i 1 ft.,. ��r�.Igl , 4 4 . � ^C-rtsM Olt ti '`ie* ' 11,4, , 4 ir .. Pag: AV i � ��t� v -4,44,4444,0, *eV lIIp If Me A,344:, Ta 7,111)F01,111 11.1 ) Altai Ate � .� 4111 I .011�1110 4,44.� � � ,r& � - etaie 4'0 Tifn 0 Ai Dren t. 3,.... �� , 1 r t11..7r" ' """tot.f4ill..67.�� *' �jr 11 _A ,114 1 . r.. ,:.,:Za , ' , , : t , "i'=,!1.04111Z:li 1:A044;1%11T ri t)te k �. .3(1? , , Va, !Ira I I" r tr4fr e t 111A0,1111 / BANK, i 19,41/14 111 t I If A K,;ir t'APPAPPA � C:6000000 0000004 O �or:506(5'6 bbbbb'obt)0'ot O000000000C IPnr ffi; 001. 4*;-;441itollitei P4,'.= � ,g114114 ; a 1 .4.a441:0�41.11141011111111 aad sf"( ,��.;�� Iffg."0,#.4 � ,. � , 0 4071, # 'ili 4 ,� r4,� � 1�. �,.., ' - ""'''"''''",' " � ' '4�'.4.? s ; /��S �i��Sot � � .= s.,, t, ,, :IV 11t111 l'�,,aukspilletvfrp AO �itlyi.19.1T716( 341. �4 NIA% Iii I ' �I NI, " I f 'ssuniissits sin [.;�,44 V,�!,f0 .011.11,1%, 11141 t imsosors � VA* � -14:11V. " putties ^, �P via*. .*444.4"4"4,4,,,..44,4,1,,,,,,, -,41-404A 4 , '4414- rof, � tr� 4 .4.4- 44 44444-43 tA34-..qo `r#q% ,r,'%c1^ - � ; 11 1 A, n, 11:4116...,,,, � Af.1.0 ,4116, � � 4441444 v+-4441 yrs ^ like% vs,.410.4 -e'r.JAWXZVI A? .0 0 .0 0 .0 6 o o 19 .9 6.96 9 7 .7 5 5 I .5 5 0 0 .0 .0 .00 '4 4 Z t 11,1 10. ttkiNk 111001ottio.....~.11.,14,111.1001111141111110.111111111111160. 0,0 Wok44 in:Ck#110,444:4,,,%%f .04~~#041,491.41iktAdOnnitt :It "91ext . 61, 41.1".t,'� Lrif I t 450 � 4'144 14v. 4,1 A Liit1131,0'4 Uibbbb 4.octiouttoui-30-ael , VIIIIMOV=v1===.1%.1,1310rIMPPF"....,., Ift,'"SA EV-P,Ilt-L' %VIVA Mt*, ; � � IF qr 411�. 4,14,711147* 1 4^ � ' .141, Wargoiller,`.011,44 **�� 'Rik," ..refOnOtenn.t., � 111 X �45, itnal Ai* 143:INitt, 44ftANV 41.42. A ' rA, t1611' ; .4 ra`r tw r � (w � I 4.111.4.4. 1506 LOGT te, iftetix-rm . � � 11` t.,14-Wk= t", � � 4000 Of ANY 0,0111111114 a. � � � 41,4114.4�4/�,.. la0.4104k, � .00 4 i � ' , ' 6 4. � ,�14 9 � � , t � 1 fo �", � ado 4114, 'Still ' Yu /1,1vvo , 3/419 9"19 � � I, � � o�� 9 9 .11111012M 4,01-A,AffiewObae.0.411"04,*114 1.= ttt, Li 41i1 lat N C� C. in c N octit.1 th-jjNC4 el et c; ett co to) as c CO r41 C kb Cti c c P.",1 , .611440 peop,,tves00,100.4,..A.+010 ,wookvc, 0,,PW.1146,9c*. re.'e,v,.. 'W.V. Pit* 44.4(40,rsioioo 44.41romem..,,r .04,06.40,04 9404.1011401, W ":""-"7*- - lok.s, 410,41"; 1" "'$*$ $ 1 't.0"/ 4140' t'" " 411,440 L. ts..i? ttil 11 5 nr t 1. it .,...7101P401* U U4)1 U 1 ,�, 4) o o 0 Lc) c; a) r- OVA Q Q fel fel or rt. Q 901 i"osmr.coc -C c 6t eN t $0:11.1141142 = 4Mr4tlekletitiPA KIN� I. IN it '.4t,4,14P;vizrzfw. ' 0�A o� � ow,* LAit=. Z tr,1,0,11, 140004.1111WA4c � t � � � a o � � kvd 44. WoodOw��osi�oloose,*e. "OdOoddroolnyto,1011**OO,OOdOMINOVO,VO�NOWOr, r�!, o O.1�111�, , g'c 11" ev ��4�11��wor� vs��.4110�416110� u u*i u � 0 ()inn cc- co co ca Qui 0. ei T-J ao:h 0. al , NI 'id T.�1. II � c, . nkt t; 00.40 170:1'70,,tillO:WAVO li3ONO ,714%01. 444 1.1�...01 � � n � 1, � � � � e $$ �5 S �� . � - .44.. � a PI 'ti I Ui � tr. ir M VA- i e mit' 0 it * MIMIA IMOSSMOMMIM iI 41 a a* . a .10 001 M 1 � � � � � 01. tilL Si"' 1 I � t �11. � � � ; . ..- � � : ./ � a � � , � �� 9 9 A=1. I, * ; I stulviw ;1=4:741:2 Nlitte s 0..xciett c, ANY gr. tIRIPite,, 1,1 toc,, 4iido ow-,41sehs4,-.4, �:t .0 0 .0 0 c .0 0 !!. 1 5 91'5 1 7 4 .1 1 7 4 .1 0 v 1 7 4 .1 0 i 7 4 .1 0 1 7 4 .1 0 .! 2.7 2 5 5 3 2 1 7 5 D STATES AND mUllf- 10 AT P4/4., sa TPIEASUltin U1I, rtrectk:* novn:17., t by autho, dat!!,: �2 I1PDET; CL BY 18 475 143140RANDUI4 FOR: SUBJECT : Continuation 1. The scope of this subproject now/engaged in by under the direction of TSD/HB with the exception of those cutout functions specifically mentioned in connection with other NEULTRA subprojects. In general, the research effort under this subproject will continue along the lines laid down in previous years. These involve the synthesis and pharmacological and clinical evaluation of compounds of those dhemical families known to have application in the psychochemicalani "R" fields. During the coming year it is planned to concentrate more directly on the more practical aspects of the � "knockout" problem. InOugkneelvtemtimbOt*Peee have become available , lately to make such a Change 121410besis vorthvbile. In connection with this change it should be noted hat certain findings made in C 1.1111101111 project atillitaich'etnnot be further exploited at el? that facility will be pursued at 11111111b in the future. For this reason it my be necessary to supplement the fUnding$ of this sUbprojeet from time to time during the year due to increases of scope. 2. Ammagamilmi also serves as a*general consultant to the � Agency, provides Services of a sensitive nature on an ad hoc 'basis, and serves as a cutout in procurement problems. �2 CL BY 187475 Do by �2 IBZDET; CL BY 18 3. The total cost of this project for period a one year mill not exceed 00,000.00. Charges should be mods against Allotment 2125-1390-3902. 6 4- 1111111111111111111111100'has been requested to submit a sualmarY a=ounting or a copy of the Fund's annual audit report for the sponsor's inspection. Also, it has been requested that any unexpended funds shall be returned to the Agency. 5. Title to any permanent equipment purchased by funds granted 41011111111.11a shall be retained by 1111.111111111111111111.11110. 111111111.1.111ft in lieu of higher overhead rates. 6. It was mutually agreed that documentation and accounting for APPROVED FOR OBLIGATION OP FUNDS: Resear�Director Date Attachment: Proposal and Budget Distribution: Original only to: of T1. � Chief TD/Research Branch PROPOSAL I It is proposed. to continue exploration and pilot work along lines which have been developed in the investigations of the past few lears in cooperation with other projects of interest to the Sponsor. The primary field of work involves the effects of stress on human beings. Major items of interest presently involve the following areas: (a) Creation at reliable research "tools" for study of *trees phenomena in animals and man with the end 132 viev of understalmling these phenomena to the extent that practical applies, time can be realized in interpreting and con- trolling human b.ohaVior. 00 The production and, study of new chemi- cal and. physical agents of significance in connection with, the stress reactions. (a) The allied. mitigation of chemical and physical agents relatedto the 'State Of a The particular. interest in this relationship is to obtain and define a separation between general 'activation or depression le animal and the very specific "perceptual" depression or activation desirable from the psychologists' point of viev. A reasonable ammint of progress is being made in the several areas 'indicated above ad it is expected that continued efforts of the sort which have proved efficacious in the past year will yield further significant results. - � AJ TICE, LiG soun AND MODS CLV ED A !NG CE O.* O.. 11.4 .1,r1111,:.1,110 ali.V '4;4 MEMORANDUkil FOR: THE ATTENTION SUBJECT Under the authority granted in the memorandum dated 13 April 1953 from the DC.-I to the OD/A, and the extension of this auchority in subsequent memoranda. Subproject 45 has been approved, and Vaeaggsall of the over-all Project NIIVILTRA funds have been obligated to cover the - eubproject/o e%.-penees and should be charged to cost center 8304390�390a APPROVED FOR OBLIGATION OF FUNDS: Research Director Date: Distribution: Original Z Mdressee 1 � TEID/FASS 2 - EIDfitla SECRET ____ a 40, 3 )(MORMON FOR: TEM CONETROLT2R MAMMON t Itnanee Division SUBJECT ICULTRA Subproject 45 Under the authority vented in the memorandum dated 13 April 19,3 from the DO1 to the DO/h, and the extension of this authority in sub. 'event memoranda, Subproject 4 has been approved, and an.nno_no of the over�alt Project MKULTRA funds have been Obligated to cover the subproject's expenses and should be charged to cost center mas 1372 3,411 APPROVED FOR OBLIGATION. CIF FUNDS: Research Director Date: Distribution: Original & 2 - Addressee 1- TED/FASS - 'TSD/RB � SECRET tram* ann NAT 7..!!!';'S � � 03..114.1Z11/4 nte:!..;:: Omni 10 45. MEMORANDUM FOR: THE COMPTROLLER ATTENTION 2 Finance Division. SUBJECT Under the authority granted in the memorandum dated 13 April 1953 from the 3CI to the DD/A, and the extension of this authority in oubsequent rnernoranda, Subproject has been approved, arid 410�000.00 of the over-all Pzoject ME:ULTRA funds have been obligated to cover the subproject's ezzpenses and should be charged to cost center 2/254390�39152 APPROVED FOR OBLIGATION OF FUNDS: Researcti Director Distribution; Original at Z Addressee TSD/PASS 2 - TSD/RB 1 C-1.- T1FY NAT !la I9s Ac.1 onicam.:14 OWCI T�MCIff AIZW.NCING orncut SECT bet tet E2 I3M11..L; CL B 87475 MEMORANDUM FOR: TM RECORD SUBJECT : Continuation of MIULTBA., SubPrOieot No- k5 1. The scope of this subproject includes now engaged in by 11111011.11101., 111111.0110111011111101111111111111111111Millaho under the direction of TSD/R73 with the exception of those cutout runctions specifically mentioned, in connection with other NEULTRA subprojects. In general, the research effort under this seproject will continue along the lines laid down in previous years. These involve the synthesis and pharmacological and clinical evaluation of compounds of those ehemictal families known to have application in the psycnnchemical 4114Mi "re fields- During the past year important progress hap been made in the area related to stressor compounds and the relationship of these materials to the physiological pathways through which both stress and the reaction to it are mediated in human beings. 'Also, several new and important animal screening technique adapted to the study of materials which depress the general awareness of animals without producing any accompanying physical depression have been made available for work on *knockout" materials: In addition, scam progress has been made in relating certain organic chemical structures to observed effects on animals. A considerable part of next year's � effort vill be aimed at extending our ability to understand the structure- activity relationships among these sleep-producing materials. 0 � � � � 1. � � e� � � � � Fl b uth y of; 475 ts; o 197 DZT; Y 187475 2. ' also serves as a general consultant to the Agency, provides services of a sensitive nature on an ad hoc basis, and serves as a cutout in procurement problems. 3. The total cost of this project for a period of one year will not exceed 0.0,000.00. (12.1cwever, at the present time the project slx A641 viii only be extended for a period of three months. The cost of this project for this periad will not exceed $20,000.0C) Charges should 4 .be made against Allotment 1125-1390-3902. (..It is anticipated. that the remainer-of the funds for the project year will be made available from FT-62 money when avallable:

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MKULTRA SUBPROJECT 45 (140 DOCUMENTS WITH PUBDATES FROM 550321 TO 63022 0)