, --- heck shculd b forwarded to Chief, 168/Chem1ce1 Division, thrvue,b 7$8/D.4get Officer, no later than /Friday, 20 June 1958* - This invoice represents the tot1 mount currently authorised under MINI--eject 53..B. Novievers, lithe. it is antic!. pitted that additional ti,a3,da vIll bs obligated for this project, t be *lotted* - r> AME-iiiNT CIF Attachment� t involea & COtitioati Distributient 0148 1.2 " Addressee 23ee07. L,.. pay Chia treS/Cheafcal Division �ov (1) It 10 berebyeertified that this to Invoice Q. 7 ap-PlYIS to _ autTrOmt 31.4-0 *DIM, that perfcammu= is satisfactory, that services are being accomplished in accordance vith naval agreements; that adetalled agenda of the payments and receipts is on file in es/DD, that this bill is 4ustsbl eorrest-snd-that papent thme _ bas not yet boon wades TSB/Chemical Division (2) It IA hereby certified that this invoice applies to Subproject 514 ofICULTRA-vhielt was duly approved, andthat the project is being carried out id accordance with the metaoranduiu dat,441 13 April 1953 from the Del to the DD/A, and the exteneicia of this anthorit in subsequent � � a authority van item the Mt to the 1)DAlk and the in subsequent netseavNiat Butpro4eot previousky appreyedi-Attollw the *Amity an rdditional sun at .11200.00 has been itbIz to ewer the Atbprosleotts expensee (thereby brinaing to a toted, of' 424,03040 NA, oblige duriez 58): to be eharseil Allotment 8-24X2-10-001. Do t Distributicni Orig es 2 Miregteee TSSAC Tss/rAsB 1 - T88/SRB 2 - TSS/CD 3 I CERTIFY-THAT-LINDS ARE AVATAKCI OILIGATION REM:E.P.C.7EN,ts?"071e chAIGE TO Alt; J. AUTticialZINFIC = A PROPOSAL FOR-CONTINUATION-OF:GRANT I propose, In the-capacity-ofchief-investigator, to pursue in the period_SeptiMbr--1,-1958-0-August_31, 1959 - a program of research comprising the following activities: 1. Chemical Inve-stigationsof-the4harmaco1ogically active constitd-entS-of-variOUS-plants and fungi. 2. Investigations-on the-chemistry'of.new heterocyclic compounds_of=potentiaLpharmacological interest. 3.. Synthesis of miscellaneous compounds of-pharma-cologi- cal interest .It is expected that the following budget will be re- quired for-these purposes:� Salaries: Principal Investigator (summer) $ 1,800 Post-doctoral-fellow: 4,200 Pre-doctoral fellow: 1,800 Total Salaries .$ 7,800 Overhead (25% of salaries) 1,950 Page 2 June 303 1958 Supplies and Equipment $ 2,000 Services (analytical, secretavial etc.) 1,000 Travel 500 Total $13,250 Approved: ir Departnient of_Chemistry rovOst and Advisor propose, n the. capacity of chief Investigator, to � pursue in'Ahes. period September-1, 1958 to August 31, 1959, -a-program of.research _cotprising_the following activities: � Chemical:invistigations of the pharmacologically': . , active:constltuents of various plants and fungi. . Investigations On the_chemistry_of-new heterocyclic- compoundS of potential pharmacological interest. Synthesis of Miscellaneous compounds of pharmacologt-: cal Interest. Xt Is -expected .that the following budget will hire gutted for these purpose ,Principal Investigator:.(su mer) $ 1,800 Post-doctoral fillowl t,200 Pre-doctoral fellow: l800 Total Salaries $ 7,800 Overhead (25%of salaries) 1,950 Supplies ,and EquIpmen _ Services (analytical, searetarlal e c.) 1,000 .Travel� ��500 Total $13,250 Provost and Advisor on �esearch I'wish to thank you very. much for the 1127dimethylheptyl re oreinol, I have started the synthesis-of-the pyranj om:Wand_the,proeess seerPS to going very well.so far. We are lookine�forwara to seeing you again in 'the, we hope, not too distant future. Th k�yo Si closed please find 2) copies of a proposal which subMItting:fOr the- continued sitpport of his research If itme� * with your approval, please_send your-usua *letter of intents to Dx The Univers : -TUE !MORD - SUBJECT : Supplement to M(ULTRA, Subproject 1-16- - 1. The purpose of supplementing Subproject 51-3 is to provide additional funds_to allow for an increase in scope of _ the original work. This_inorease in-scope consiats of the-- synthesis of a number of otherwise unobtainable chemical compounds which are needed in other projects. 2. The cost of_thia_supplement_will not'exceed $1,200.00 and charges should:be made against Allotment 8-2502-10-001. Since 7 ! � Subproject 51-B was-originally funded for a total of $22,880.00,, the new total for this subproject will now amount to $24,080.00. 3. All of the fiscal_control and ie.mrity provisions contained in the original Memorandum for_the Record on Subproject 51-B1 dated 31 July 1957, will apply to this_supplement. TSS/ChemiCal Diviston OVED JSR OBLIGATION OF FUNDS: Date: Di f y ,L4. Distribution: Original only Attachment: Original Pro.esl ' Dear project. Enclosed please find two (2) copies of a proposal which is submitting for the continued support of-his research If it-meets.with our approval _please-send-your Aasual - "letter of intent" to Dr The University deeply appreciates the help and supper which the has given 6) Very trulyyours, As Enclosurest Administrato eh A PROPOSAL FOR RENEWAL OF GRANT - I propose, in the capacity of chief"investigator, tO pursue in the period Sept.- 1 -1957 to Aug-31, 1958, a pro. - gram of research comprising-the following activities:_ = 1. Continuation of effortt_to7procur 'samples of selected botanical materials of potential pharma,_ cOlogical interest, to arrange-for their-propaga* tion, and to investigate the principles responsible for the pharmacologicalactivity. 2. Continuation of studies of new heterocyclic systems, with_emphasis on seven membered nitrogenous-Tings. 3. Provision of facilities for the synthesis of 3e1ected compounds of pharmacological importance. It is expected that the following-budget will be re- quired for these purposes: Salaries: Prin. Investigator $7,066 Post-doctoral Fellow (1) 4,200 Pre-doctoral Fellows (2) 3,600 Total Salaries Page 2 July 5, 1957 Overhead $ 3,700 Travel 500 Analyses _ 1,000 Equipment and Chemicals 2,000 $22,000 Approved: on Research Provost and Advisor s 1nvo1ezwretktentis that Vaal ariourtt currently under Subyralact itD1 Hoverer, since it is antioi- tional iNoiss-vill be obligated for tbie projects not be THE 'AMOUNT OF $ Attecbssent Invoice & Cart tications Distributionl Ctri & 2 � Addrome � 1 - TSS/FASB 2 - TSS/CD N T fSet 0 r cT:Fy Ti FLNDS A;Zi: AVAILASLE4 cuteATIO.4 04' E CHAViE T � (1). It is hereby certified that this is iretarwe No. 6 soiling to - Subproject 5143 of 141MVIA, that perfonnance is satisfactory, that services are being accomlishaelin seaoramee vith mutual agreement*, - that a detailed agenda of the payments and receipts is on file in 1138/CD, that this bill is just anti cornet end that parent there-of has not 'yet been ads, (2) It is hereby certified that this Invoice applies to Subproject 51-13 of MUSA Vhich vas duly approved: and that the project is being carried out in accordance vith the Mesorandtre dated 13 April 1953 from the DCI to the DOA, and the extension of this authority in sub. � secuent Receipt is hereby acknowledged of the following two checks: Cashler?s h c o dat �s 23, 1957 drawn on Th he amount of $293.33, payab e 333.3 ,payai e to The checks -should be forwarded to Chief, TSS/Chenlica Division, through TSS/BUdget Officer, no later -than Tuesday, 20'August 195 RTincArto it I. hereby certified that title Is Invoice 1_5 applying to Subproject i51-B of MKULTRA. that performance is, satisfactory, that 'services are being accomplished in accordance with mutual agreemente1 that a detailed agenda � of the payments and receipts ii_on� file in,TSS/CD, that this bill is just and coned and that payment thereof has not yet been made. c, (2) It is hereby certified that Otio invoice applies to Subproject #51-B of 11KULTRA which was duly apProved, and that the project is being can.' ed out In accordance 'with thimemorandum dated 13 April 1953 from the DC1 to the DIVA; 'and the extension this authority subsequent memoranda._ - Research Direct� oll-�� _ - ei1.1�11.1Maawirg-ftiaffmimal. 4010, 4p." 047'4. 7 �VAK � or ChAk ,iQ� "Ar.,^4 - - Distributiod: OM S2 Addreamit 1- TSS/OC *1. - TS3/SRB 2 -T33/CD rn 3 CT KULTRA-Subproject Igtvo!ce No. 4, Allotment 7-2502-10-00 heck in the amount of $810.00, drawn on bank,.� heck in the amount of $15,250.00, drawn on k. - ade payable to th 2._ Please forward the checks to Chief, US/Chemical Division through TSS/Bedget pincer by Friday, 5 July 1957. Th.1 is a final invoice; A total ot $23,190.00 was ob7 ted under this subproject during FY 37. However since it is anticipated that additional funds Iv be obligated for this project, ;the tiles should_ notbe ' 1 . r " Acting Chief TSS/Chernical Division ttachme - invoice & Certifications se7 .0004)-1 400d /I? 4t 841.00 is;e1o.00 CERTIFICATIONS ( ) It is Lereby certified that this is Invoice No. 4 applying t� Subpro:eet 51-A of MKULTRA, that.performance has been satis- factory, that the services have been accomplished in accordance with mutual agreements, that a detailed agenda of the payments � and receipts is on file in TSS/CD, that this bill is just and correct , and that payment thereof has not yet been made. s (2) It is hereby certified that this invoice applies to Subproject � 51-A under_MKULTIIA which was duly approved and that the pro- � ject has been carried out in accordance with the memorandum � dated 13 April 1933 from the DCI to the DIVA, and the extension of this authority in subsequent memoranda. Receipt is hereby acknowledged of the following two checks: a s che k No ept 17 1 f $305.00, payable to HEM' RECE .- vertu/ the abov uhpro, et le tech. . her tiwotcea 'wtfl fbflow later. It is requested that payroent made by cae4cr cheta ea follows; .. �.. 'be a for $1,623.00, drawnna bank, Cheek for$202.00, drawn on a ank. , .. .,, - e �sO lb,ade payable t iti-to4�ti *_to Chief, _TSS/Chernical Divi- o --114Sf13p4 by Friday, 21 September 1450. SIDNEY GOTTLIEB Chief _ WS/Chemical Division taehm � ohm irk .Dis tributlon: OrI�T&S/Ct) 1 * Comptroller TSS/FASB TS.S/CD it September 1956) CHECK .N ThL AMOUNT D RECEIV ,3 tEr.,77Y A ?".17:-:1", � 0,1 BATIFICATI9N 1) it is hereby certified th4t this Is invoice No. 3 applyIng to Subproject 51=A, of MKAJLTBA. that performance is satisfactory. -,. that the -service-1i are being accomplished in accordance with , mutual agreements, that a detailed agenda of the payments and receipts is on file tit TSS/CO3-that this bill is just and correct a :that payment thereof has not yet been made. � (2) It Is hereb certified that thislinvoice 14.pplieti_to Subproject 51-4. under Snit:VIA _which was duty approved and that the pro- ject Is being carried out in accordance with the memorandum . dated 13 April 1953 from the DCI-to the DD-TA and the extension' of this authority ta�-slabsequent Eueoranda. . - DearDr Enclosed please find th eceipt totalling $58718.7 which co period September 1 to November 30, 1 � As soon as the August fiscal statements are available to this officer we will give you a financial statement �for the past year's research expendituxes. If then, is an un- spent balance at that time. may we suggest that you subtract it - from the next payment, on December lo 1956. The University is pleased e'CO pletely satisfied with the contract*, and Vat con- ducting such a splendid research program4'.: - CERrh' 'FUNDS f%.7:1 AVAILABII: CatiGAThst4 ;FUENC pie., 10 � SUBJECT: MKULTRA, Saloproject 51-A: se of Subproject 514Jis to contipueithe_vork_of,_--__ - Dr on botanical materials having a psychechemical-effett Dr as to document the pa cal effects and to iden y positively a-SteciWof ceren0Ai ,Mushroom_Nhich promises to yield a completely new camical agent Of_this_typei: It -- -- -is quite possible that the precise identity of this material, If the --work can be successfully carried out, can remain =Agency secret, 2. The scope-of this research program-is-outlited in detail in the accompanying_prOposal. It'sheuld be emphasized that item(s) therein, providing syntheticAvilities, has-proven to be very valuable in the past yeardeffinal products and. two very useful-- intermediates were securely-prOduced-at very 167-co,it and in .a few= days time by this arrangement. 3. The cost of this program is e imated to be 422,875 for a period of one-year.- To this sum mus � added �1'.00'representin a four percent service charge to the Therefore, the total cost will-not exceed $23,790.... .arges should be made against Allotment 7-2502-10;001eak,no.,20- 4. The has requested the University to submit to them a summary accounting of monies received from the Fund. Als they requested the return of any unexpetded funds received under a grant from the /UM on conclusion of the program. 5. Title to any permanent equipment purchased by funds granted the University shall be retained by the University,1n-lieu of higher 0-C overhead. rates. , _ 6. It was mutually agreecithat documentation and. accounting for travel expenses which-are-reimbursable-by-the University shall conform with the a4cepted practices of that Institution. eement. APPROVED FOR OBLIGATION OF IFLTM: ree o Date: Distribution: OriginA3 Only d. o comply vith the re uirements of the /4K _ Chief, �E6jCheadca1 Divisioa ISS (27 Avzust 1956) A_TROPOSAL - I propose, in the capacity-of-chief investigator, to pursue in the period Sept. 1, 1956 to Sept 1,-1957 a program of research comprising therfollowing-actiVitiess_ _ 1. The procurement of various plant_ materials, including some rather difficultly:aeoessible7-fungal species, which have been implicated in reports to contain substances causing dis- turbances or changes in-the-central nervoes:system.:=:-1 - 2. The processing of these materials by extraction and frac- tionation procedures, with the purpose of-obtaining extracts. and eventually pure compounds responsible for the biological - activity, and of furnishing such-extracts for pharmacological evaluation. 3., Determination-o(-the -stucture of the -pharmacologically-_ important constituents-of plants obtained as described_abeve,_ or other natural products obtained from _various contacts in the field which are being cultivated-and maintained. 4. Investigations on-the-synthesis and properties of new - Ixpel of heterocyclic compounds,* using as one point of depart- ure the new diazepino ring_sys eh re u jfrom-rin -clo- sure f diazoacetylpyrazolin (1955)) and as another-po n closure rea tion o e or suitably substituted -diazoketones, with the purpose of exploring both the chemistry and possible pharmacological usefulness of the novel Substances which can be expected to arise. 5. Provision of facilities for the synthesis, on short not- ice, of selected compounds of particular pharmacological inter- est. It is expected that the following budget will be required for the program outlined above: Salaries Principal invest. Post-doctorate fellows (2) Pre-doctorate fellow (1) 6,500 7,200 Total Salaries 615,500' OVerhead (25% of:salaries)-7i- / _Travel-Expenses-:- Services (Analytical etc. Supplies and Equipment' 3,875 -- 1,000 2 000 $22)875 CHEM' CHECK� A IN RECETNIts ass V' 1 CE1:1Y( 1 : ��'�' � oeuGA-,N 4,/,� CE.011 Te? � e.,..rt 6:10 � 0 0/ ALCTI-ntiG Oir.CEX ICATIO1i I. It i f -is hereby car s nvo 04 /2 appliing to irojeot i of MinifITRA,, that sperformance ia-satisfaQtory, the. service* are being aocomplisbed in accordance with muti2a1 keen-tap that a detailed agenda ct the payments and receipts - On file ii MAN that this bill is jtibt and correct and t thereof hem not yet hew sea , Fnc.Losed please find triplicate copies of the - Financial Report_for_the period September-14-1.955_to_January 31, 1956. This Financial Report is for the grant which supports fundamental research in the field of centrally active substances. nc osures I certify that tho listed expenditures are just and reasonable and that the work has been performed saiisfactorily, SIDNEY G KLILB Chi!sf TSS/Chemical Division Principal - Principal Investigator, $500 per month. 2,500,00_, Research Fellow, 1 per month,' 750,00 Research Folio month (Octo $3,850.00 (h;erhead-,,. 2X of Salate & Wages 962,50 xoendabi 1.!.�4-56 k - - 8,731 1.92..56 Ck, Co, d -ethy utana pen n _ 473 ..*, -- -atralite P 12..19-55 Ck, Co. Caine54.00 6,60; 6,60 1,35 _ 10,15 5.089,65 L A )(X j_E.4,,TE .019.1_,,UNES AS OF JANUARY 31, 19561 10,910,35 61-v:: 1.3* ) � -.an to th 500 per month Research Fellow, per month . Research Fellow month (October 0400 tin v rsity of The purpose of_this Nemorandum,ofAgreement is to set forth the mutual administrative responsibilities of the prindipal__ _ . research investigator and the sponsor.. Therefore, it is mutually _agreed that, A. The principal investigator shall submit to the sponsor, --at,7_six-month-,intervals,-arl'informal statement5of expenditures of -------- - monies advanced for research activities. It is requestetl_that the statdment5be submitted in essentially the following , Personal compensation (salaries, sUblect fees) Equipment � Supplies and Services Contingencies Overhead B. It is understood that any travel expensesTincurred in - the furtherance of the research program-will-be-accounted to the University in a manner consistent with its eStablilhed practices 'and policies. -5 C. The principal investigator Shall submit to the sponsor seannuai.reporta,pn_the-technical:progress_of the research covered by these . s c.t IMMUNtFCR: THE RECCRD -SUBJECT : Telephone conversation with 2. Fe asked that I contact Di.; preferably before he leaves an area future relati7. h and along the lines that Dr had already covered with he-lie-lias assured that this would be done. 114 was-instructed.to get in touch with Dr. in e concerning any.details-about the netz arr ment a Distribution: Orig & 2 - TSS/CD � TSS (19 September 1955) - I hereby acknowledge receipt of the following: Official Che tad 10 October 1 drawn payable to th � ) in the amount o 33. Date:: 1) It is hereby certifiti�the this is LIVOiee IXapplying to bprojeot 51 of MR-ULTRA, thItt-perfonsance is satisfactory, that e services ero being accovplishea in tocordanc. vith )nutual . agreements, that a detailed agenda of the paymente_and r*ceipte - is on file in TSSADi that this bill is just and correct and that payment thereof has not yet bean _ ) IJ.s hereby certified that this invoice applies to Subprojeo 51 under mculLTUA111,0h 'Ws duly approved and that the project is being carried out in accordance with the nelsorandica dated 13 April 1953 trot the DOIA�the WA, and the extension of this authority in subsequent nenormde.- . 1014aRANDUM Fat: THE RECORD SUBJECT : MKULTRA, Subproject 51-- pc The purpose of Sub materials by Dr. v rs \- t iist�oontinueworkon formerly of the as recently relocated at t 2.. The scope_of the research pregram will be to pursue studies on the detection, isolation and chemical characteri- zation of new compounds having central nervous system effects which may occur in various plants._ The.programwill_also study new types of heterocyclic compounds-whtchmay be useful in preparing centrallfeetive agents. , a;971" 3. The cost ofutble:program is estimated to be $16,0W for a period of To this sum must be ad 0 0 AP4a� tnting a four percent service charge to the Therefore, the total cost will not exceed $1 3.)71 se.0 rges should be made against Allotment-6450240-001. 1 has requested the University to - submi the ma accounting of monies received from _ the Also, they requested the return of any unexpended funds received under a grant from ,. th. � tic ' r 5; Titleitoiany permanent equipment purchased by funds granted tht-Uniiiersity-shall-bW-faiid by the University in lieu of higher overhead rates. 6.. It was mutuAlly agreed that documentation and accounting for travel expenses which are reimbursable by the University shall conform with the accepted practices of that Institution. _ ' 7. Dr greed to comply with the requirem the Memorandum o Agreement. APPROVED FOR OBLIGATION OF FUNDS: Re Date: or 6 e#. Distribution: Original Only TSS/CD 15 September 1955) f Chemical Divinon It is proposed to-pursue-studies On the detection, -isolation and themical-characterisation of new compounds having central-nervous-system effects whith may_occur-in__ various plants. It is fUrther:proposel-to-studynew-types of heterocyclic compounds which-may-be-useful in preparing centrally-active-agents. It iS expected that-Ahe rolloWing expenes will be incurred in the-course-of-thie program-during-a-ons_year period: Salaries . Materiala & Supplies Travel Expenses-.---. Overhead--. Miscellaneous . . - 500 0-0 elf 1.500* $16,000 � � - 'Total , 'Aa4itiona1 . :- '"Peria. Tim Fa-ter4fx1 AU ot*e_ut Anounit 41 - . Authorization3 _ 21 Covert-,11, * C..1 011fottion . - - ..... -....... '! , 0., Li, 4,2sAvs3w-..,5-iez /e7.-62, 5-/- '17 Project C.179 KULTRA 51 ated: 16 September 1955 Data /Dxpir : 16 September 1962 runds carrent year: $10, 712.00 Purpose: To provide by synthesis compounds i I � _ I - 0.4E, ...WWI. �E0E1�95611 11 1 myjim priimms aatnAriovs I OBLIOKILIOilt3 triutaumuo riaRM � 1,10131M - _ BATA= � _ -01T � / f �e",,&,-- � .00.1 1 I [ r -1--- I - THAT iHoRiz AUG 19 DRAFT 18 August 1958 MEMORPNDUM FOR "ME-BECORD SUBJECT ; MKULITtA, Subproject 51-B Afr 1. The purpose-Of Subproject 51-B is to continue the -work of Dr. on botAAfcal materials having a psycho - has been able to document�the psydhological_effects and _to_ identify positively a species of ceremonia new chemical agentJof this_type,-:It is quite-possible-that the precise identity of _this_materialican:be-_detettined during -the coming year, 2. The scoPe of this research program is outlined in detail in the accompanyIng_proposal. It should be emphasized hrooms which promise to yield a completely that Item Noi-3 therein, providing synthetic facilities, has proven to be veryvaluable in the past year. Several-final products and two very useful intermediates-were securely produced 7 at very low cost and in-a few days time by this arrangement. 3. The cost ofithis-prograoris-estimated to be $15,650 for a period of one year. To this sum must be added $626.00 representing a four percent service Charge to the Therefore, the-total cost-will not exceed $16,276.00. Charges should be made against Allotment 9-2502-15-902. ' I&. Te has requested the University to submit to them a summary accounting of-monies received from the Also, they requested. the return of any _unexpended funds receiVed Ander-a-grantql% the on conclusion of the program. 5; Title to any permanent equipment purchased by funds granted the University shall be retained by the University-in-lieu of higher overhead rates. 6. It was mutually agreedithat_documentation end_accountirg_ for travel expenses which isre reimbursable by tbe University shall conform with the accepted. practices of-that:Institutiono agreed to comply with the requirementsof-th Memorandum of Agree ent. Chief TSS/Chemical Division APPROVED FOR OLIGATIONOF FUNDS: Date: Attachment: Proposal Disbribution: Original Only 500 Total- $15,650 2_92P 0,2scl Principal investigator $14,200. Post,doctoral-fellow 4,200 Pre-doctOralJfellow 11800_ Proposal for Continuation of Grant propose, in the capacity of chief investigaor, to pursue in the period Sept. 1, 1958 to-Aug._31-19591 a program of research -- comprising the following activities:__ 1. Chemical investigations of the pharmacologically active constituents of various plants and 2. Investigations-on the chemistry of new heterocyclic com- pounds of potential pharmacological interest. interest. 3. Synthesis of miscellaneous compounds of pharmacological It is expected that-the following budget will be required for_ the program outlined above: Salaries: Total Salaries_ 10,200 Supplies an4-EquipMent 2,000 Overheat 1,950 Services (including-analyses) 1,000 Travel 11 August 1958 Receipt is Cashier's_che drawn on the paynb e-to th � AP _ - - 67. � jug 1453 e1- 00 ..11�� - - - _ - I kulybvird DIM 1 IMAM AID RMIRPCIS I IMITial) mum= - BAT ME 011.1,TIMMS makaacee tri:WIZATED 1 2 JUN U!958 JUN - � 1 413.-..�� -r - - _

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MKULTRA SUBPROJECT 51 (123 DOCUMENTS WITH PUBDATES FROM 550915 TO 65021 7)