MKULTRA SUBPROJECT 135 (16 DOCUMENTS WITH PUBDATES FROM 610616 TO 64061 9)
Document Type:
Keywords:
Collection:
Document Number (FOIA) /ESDN (CREST):
00017394
Release Decision:
RIPPUB
Original Classification:
U
Document Page Count:
23
Document Creation Date:
August 23, 2024
Document Release Date:
September 8, 1976
Sequence Number:
Case Number:
Publication Date:
June 16, 1961
File:
Attachment | Size |
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MKULTRA SUBPROJECT 135 ([8144491].pdf | 1.07 MB |
Body:
Project 1411J12R�Veabprojecit 135
tato) Initiated' 15 footeabier 1961.
Date Wrest 1 Octdber 1962
Fundeecurrent ye&rs 4214670.00
Purposim To ProYPIeTfor Ylvestigations involving c/inial testing of
volunteers in proexans of-TODrintereit.r-Tbe project will provide a__
facility' and a_team of medical :supervisors as vell ass wok -stole .
reservoir of volunteers, �
Status: Project is approved bnt Ms not been aotivated.-Activation.
will be attempted b 1 Septeaber 1961.
�Cost-Account
Object Class
Date
9 AUG
%a 1461
marks_and References
Obligations Obligations Unliquidat
- Incuried - Liquidated --- Balance
1Ar
/
."4"1:17 402,
..14-1M14
A
EmOrt A NDIJM OR: COMPTROLLER
ATTENTION Finance Division
SUBJECT UKULTRA, Subproject 1 5
Under lhe authority granted in the nt effloranduw dated 16 June
1961 from the Del to the DD/A, and the extension oftMa_authoritytti
subsequent memoranda, Subproject 135 has been approved and 425.868.
of the over-all MKULTRA_project funds has been obligated to cover the
subpr ject expenses. _This obligatton of funds should be charged to
Allotment 2125-1390-3902.
APPROVED 1011
OBLIGATION OF_FUNDS:
'tat simd
Research Virector
i214\
Date:
CERTIFY' THAT FUNDS ME AYAN,ABIA
coQ400t3s,Rmit4cEM.
vAPcAjo ALIO'rp:',...4
4,01�
AliTtiOCi. 4G Of F
Distribution:
Ovig & 2 - Addresse
1 - TSD/OC
U-ZTSD/FASS
2 -
12Jlly 1961
MORAN= CAW, 71NANCS
VIA t VID/Budzist Unger
SAWS WVISM, OubproJent 135,
A11otafrit12125.1390
*-141191,412 NO*1 COVerind tate eolkAr ItlibPrOtot it lattatb.1*
Parent should too nada as fellows:
.2.�P ass fo checks to Chief, IVONsearch Drariehp
WOW:A $DfD tQtticar, Ho later than 21: July 1961.
t
3. Thi$ is a final invoice. Hovevero sine. it is anticipated
that additincialittitads_villobligaVed for this project, the filas
should Dot _tre1414e1.
At chments:
C44-tifications
Distribution:
Ori & 2 � Addresses
1 ---TSD/FASS
TSD/RE: FiEL
RT:r111
I CERTtFY T:HAT FUNDS ARE MAILARF4
CiALIGATON 2.EARailCf. go.
gtAy_CA 10 LL17,,,,,,FNFJft
_
� Atini0kZING ciFiCEA
C: ":""".!:'!TOF$.Q?
cel /pa/
.!NT OFrm,
INVOICE--
For Services-
cs � _ �4Y- en
CERTIFICATIONS
Miladisoinajaar:O.
(1) It is he rtified that this is Invoicaj1 appipag tO subvProject
N00,13s of ULTRA that performance-is satisfactoryi-that services ors1)0ing
accomplished in accordance-vith MUtUal agreements, -that a detailed agenda of
the payments andLreceipta is on tile in TSD/RB, thatithis-bill Is just and
correct and that payment _thereof haS-not -yet been-made.
_
Date:
..earme
Ohlef, 'SD Research-Drandh
(2) It is hereby ertified that-this-invoice-applies_to SuWOject
of KULTRA v:lich_was dulyapprovedutuld-that the project isiibeing carr ed out
In accordance vith the memorandus-of 13 April-1953-from-the DCI-to, the-DD/A,- _
and the extension of-this authority in subsequent memoranda.
Date:
Res arch-D ec cr
(When
ed In)
CONFIDENTIAL FUNDS POSTING VOUCHER
VOUCHER NO. 7.12
DATE 2.8
VOUCHER NO. 7.12
DESCRIPTION-ALL 0 HE CCOUNTS 13-33
STATION
40-42
F
u
45.46
PAY
CODE
47.52
OBLIG.
REP. NO.
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CA
54.57
GENERAL
LEDGER
58.67
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6.8.
OUE70
[ DATE
711.so
AMOUNT
DESCRIPTION-
ADVANCE ACCOUNTS
20.33
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CODE
PROP. NO.PIN,C00%.
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CODE
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SUBMITTED BY
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VOUCHER NO. (Finance use on y)
PERIOD OF ACCOUNTING
FROM 1 December 1961 1
TO 31 Aesy 1962
RECEIPTS
DISBURSEMENTS
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CHARGE ALLOTMENT
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196.4
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DESCRIPTION -
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FORM ,1r,
8.61 - USK PRIVIOU5 EDIT
0
g
MOMfed _I =MD
012a0if
t )0XLMVOrtzbprej444 Ws 914 914.fird 13,
Moos taO cvietn of tho audit of Projeot-WOLTRA for the period
*53, accountings ho bon received
ia- the mount of 493,671050
.93 Worm to be Booctiated for
graztoea at the. odd of -the audit pe
Subpmloot 70 talcum& direct coati of 0,54,34 end
triouxforrol. frau thdowojeot 94, for -a total of 430,390.50.
ineuma_0444.101_40_ 471/324�87, but trunfirk44. 44,165�71
1}-eot 91 44d_$Z(0072-�16 toT-%11-ProJeot 70, 1etkv145 met *OSt of SSA
VS. dooLded_to_divert_the fonds for Subprojeat .133 to Wyprojest 91,
therefOre those cote vete 1=111444 in the weak-114ratruSubprojeet 91.
Nasmoh as: _ 1) ail row of the subtir-NoToU had the sem batio to -
switch goal in said, 2) the groat leagth of tito that, bas clod since
the groats wre made atid 3) the difficulty ingettlas a000untiess of
at Reit frog the, p it IA riteeagtM1434 that ueGfaallitate_this sat.
ter kr ascot the balatoesae e4W.in in the 0oIlfidootial /Ws
DifittiOA 760 acouit- for those subWok,We
Tho above has 'bawl ocaourted
Statt*
Oranfs
February 1? 1961 to January 31, 1962 000.00
Less, previously reported
February 1,1962 to July 31? 1962
Total
�
Accounted fori-as�follows:
Salaxies
Payroll Taxes
Baployee Benefits
Laboratory Supplies and Expense
Travel
Other Direct Costs
Indirect Cest*
Total Costs
iiii7FRif64ily reported
Total Accounted For
441P6MQ 1-
--------__
644 O'er
ikdwass.00.001� ,S4,1- qi
,131.14
. 1,460.08
355;68
3511,8
569.63.
2,569.17
2 � 26
At -
Date of Origloal kd Allre,7,7-it6at ttraturt, of
Aathorization Covetzia To- . : nitib-;tt
ifezi
Alditional
AlIthorizat
TI,Krza 13x.tem.1./A.
Coirztred To
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mariERA Subproject
At -
Date of Creifdtz%1 ilsd All rt hiallit of -
Authorization Coveral 1,01),a,r Ctzligation
������..
Al_ditickt 121.r..3-AX t-g)114I-4 1 e Gat cavAm,41/4,
Atitrizat1oll ---":
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- 4
16
st 1961
We are pleased Ob. able to transmit to you the follovein
fUndes:
These funds represent a contribution for the uae of your
directors ili-cir-rying out the very worthwhile research goals of
your obligations,
Yours
Attachments (2)
DRAFT
31 May_1962
MEMORANDUM FORTHE RECORD
SUBJECT : Project MKULTIWSUbproject
Change of F�aciIity in which_ Work is_Perfortned-
1. The original purpose of this subproject was to evaluate
a number of candicate_chernical agents in facilities and under the
direction of individuals_who, if later developed, became unavailable
for this purpose due_t_o_mfor_en circumstances.
2. In the meantime, the funds for thisznibproject_were
transferred to the_cutout_in anticipation of the commencement of
the work.
3. In view_of the security difficulties involved-in the actua
return of funds frotri_the_cut and also since another subproject
(#91) was being served by_the same cutout, and furtherrnoresince
Japroject #91 was capable of providing its services on; these
chemical agents of intereetArtdduring the same fiscal year, it- has
been decided to divert the work intended for subproject #135 to the
facilities of subproject #91. No sliiicant change in funding or
variation in fiscal year is concerned in this rnatter.
CONCUR:
- Chief, ca S rvices 'vision
Date:
TSD/Research Branch
Distribution:
Original only
fj
112MOBAXLM
VIA
SMUT 10101LTI1ubproject 1351 IrtiMita. 1
Allotment 21254390=3902:
C/MAY, ITRANCUDIVISICSI
,iSDIBt Officer
1, Invoice No._14overidi the *boy*e ctttscbe4.
Permit Should made evfollowst
2.- PleaSe_forvard the cheeks_to_ChieL4 TSD/Reeearch Brian
throush TSD/Dud thew
get Officer, so later July-1961.
3. Tide lice titFlnvotce. Dossier, sine* it is **tic/rated
that additiodal 11fl4s obl t�4 for this project, the files
should sot be_oloutd.
Attack= I --
TAVOice & Oertificetiods
Distributions
()rig & 2 � Jttresses
1 - TSD/77428
TSD/RB
-
For Services
..s M .
CERTIFICATIONS
(1) It is hereby certified-that_this applytuAo_axtproject
No. 1.15_pf MKUITRAI-that performance la satisfactory, that services are beind
accomplished in accordance-vith mutual agreements, thatTa_detalled agendalof
the payments and receipts is on file in TWEE, that this bill_is_just and
correct and that payment thereof has not yet been ma4e,
Date:
ChIef,TSD/Re8ea--ch$ranch
(2) It is hereby certified that this invoice applies tolSubProject-5
of MUM vhich-vse-duly:approvedi- and that the project isLbeing_carried out
in accordance with the 13 April 1953 from the_DCI to the DD/A,
end the extenaionofLthisauthority in subsequent memoranda.
Date:
Research DfircM77777
MEM 11ANDUM ; CO/APT14-01.1.Ett�
ATTENTION ; --Finance Division
SUBJECT MKULTRA, Subproject 13
16Jne 1
Under the uthority granted la the memorandum dated 16 ,z
1961 frora the Del to_thi DWI%) and the extension of this authority in
subsequent memoranda. Subproject 135 has been approved and M, 865.00
of the over-alt MKULTRA1)roject funds has been Oligated to cover the
bprojeet elposes. This oblWtion of funds should be charged to
Allotment '212$-1390-34
APPROVED FOR
OBLIGATION OF FU
Date:
Distribution:
Orig & 2 .-Address
TSD/OC
1 - �TSD/FASS
42--::-TSD/RB
MEMORANDU
SUBJECT
DRAFT
16 June 1961
FOR: 1111 --THE RECORD
_ MKULTRA, Subproject 135,
1. The purpose_of_this subproject is to provide funds to carry out
a research program involving utilization of human volunteer subjects.
2. This program is designed to exploit clinical and laboratory
facilities and professional klumledge in providing answers to specific
questions of direct inte-rest to the Agency. The nature of the investi- _
gallons to be carried out efxo passes pharmacological and clinIcalIIIiIIIIiII
testing in human_volunteers of chemicals, biochemicals, and biologically �
active materials -under controlled conditions. For example, human
patch testing or human bl&sd group determinations will be mounted upon
setting up a suitably designed experiment.
3. The investigations will be carried out under the general super-
vision o
This individual will serve as project c:
leader and coordinate all phases of the research program, select and
provide clinicians to conduct the experiments, assist in planning the
experimental design and protocol, and supervise the preparation of data
and reports. The attached proposal indicates the nature and extent of
some of the investigations that will be carried out.
4. The funds for
reject will be transferred using t
'Oilt-out.
. The cost of this pfogram for a period of one year_beginning 1 July
1961 will not exceed_$24,870.00. To this sum must be added_$998.00
representing a 4% service charge tot
ho will act as a cut-out,:making the; total. amount $25,868.00.
Charges should be made �inst allotment #2125-1390-39_02,
6. Th
III require the princi-
pal investigator-who adminiSters'the, grant to submit to them_a summary
accounting u-pon anannuaLb�isioLa1Lm�nies received from the
Also they will require-that any unexpended funds be returned_as_soon as
possible upon the close of_the grant year.
7. -The requirement for a six months informal accounting on the part
of the principal investigator is waived.
8. It is not anticipated that any permanent equipment will b-e required
for thii program.
9. It has been -agreed that documentation and accounting for travel
expenses which are reimbursable shall conform to accepted practices.
10. It is agreed that technical reports reflecting the progress of the
research program will be accepted at mutually accepted intervals.
11 as signed a memorandum of agreement and holds a
TOP SECRET Agendy Security Agreement; The project will be unclass-
ified after it reaches th
TSD/Reearch Branch
APPROVED FOB 013LIGATION
OF FUNDS:
Date:
Attachment:
Proposal & Budget
Distribution:
Original only
PROPOSAL
_OBJECTIVE : � To establith a professional organization for the primary
purpose of servicing and conducting complete clinical
evaluations and testings upon demand.
'If addition to prescribed activities, to maintain itself on
a standby basis and to be able to mount clinical projects
on-an-ad hoc basis.
PROCEDURE : see attached sample protocol for patch testing.
CLINICAL FACILITIES:
LABORATORY FACILITIES
3s---
(t)
Th
PROFESSIONAL STAFF
/
BUDGET: ( 12 months period )
Principal investigator
10,000.00
Professional staff
6,200.00
1,800.00
Secretarial
Eapendables, chemicals, supplies
1,600.00
CliidcaLstibjects, fees
2,500.00
Travel, maintenance
2,300.00
470..00_
,Insurance, malpractice & liability
Total
24,870.00
no overhead or fee
OBJECTIVE:
PROTOCOL
To determine whether an unknown compound, either chemical
or biological, is capable of eliciting a reaction-when applied topically
to the skin, either locally or systemically, or both.
BACKGROUND :
- If the skin is able to deal with the irritant compound, the reaction
is physiological or normal. However, if the action of the irritant is ex-
cessive, th-e-reaction is pathological or abnormal and irritation results.
Irritation is an extreme reaction of tissues to an insult or injury and is
best characterized as incipient inflammation. = The iTiflammatory process _
may vary from a barely perceptible hyperemia, to edema formation and
vesiculation and finally to a-suppurative process.
A primary irritant may be defined as a substance producing an
injury on first contact, The resultant injury will depend on the nature
of the irritant, concentration of the irritant, and the total elapsed time
of exposure. Primary irritation of the skin is usually measured exper-
imentallyby_the patch test technique on abraded or intact In of the ex-
perimental animal, for example, rabbits, guinea pigs or man.
Exposure of man is predicated on small animal studies used to
screen all compounds to be tested to obviate exposing man to severely
sensitizing substances. Granted, in the case of compounds whIth may
be only mildly sensitizing or in which small animal studies are_unable
to furnish unequivocal results, man may appear to be the only feasible
firial test subject.
Animal experimentation data should include acute, subacute and
chronic_clerrnal toxicity experimentation that will allow some logical
assessment of the local and systemic toxicity of substances_to be applted
topically to man in the proper amounts, concentration and frequency of
application that may be tolerated.
PROCEDURE :
For pilot_studies, human testing should employ 20 test subjects
per compound tested. Prior to experimental testing, maximum efforts
must be made to minimize the risk of incurring unforseeable sensitivi-
ties and untoward responses by establishing a baseline profile that will
encompass the following :
1._Complete medical histories with emphasis on known sensi-
tivities and drug idiosyncracies.
2. Preliminary physicial examination
3�Hematologica1 evaluation ( complete blood count)
4. UritTalysis ( microscopic)
SRadiological screening ( chest and long bone)
Acute dermal toxicity. ( Single exposure-or primary irritation)
This will utilize the patch test technique on intact skin on a min-
imunrof_fiwsithjects per test compound.-
Methodology will consist of introducing under a one inch patch -
0.5 ml (liquid) or 0.5 gm (solid or semi-solid) of test substance and
securing the glitch in place with non-sensitizing adhesive.
After 24 hours, the patch is removed and readings made on the
resultant reactions evaluated on the basis of the following scores:
ElTaluation of Skin Reactions
1. Erythema and Esthat Formation
No erythema 0
Very_slight erythema (barely perceptible)
Well defined erythema 2
Moderate_to severe erythema 3
Severe erythema (beet redness) to 4
Slight eschar formation (injuries in depth) 4
11b--tal-Ossible erythema score
2._ Edena Formation
No�edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of wall well defined, raised) 2
Moderate_edema (raised approx I mm) 3
Severe edema (raised more than 1 mm-and
extending beyond area of exposure) 4
Total possible edema score
Readings are again made after 72 hours of exposure The-
final score represents the average of 24-72 hour readings