108 PRTOROSAL his proposed to continue research otrproblerns critkalAo_a claification of the fundamental aspects of the stimulus-rsponse relationship in biological systems. Studies will be conductod utilising chronic animal preparations with permanent_septal electrodes. intsstigations viU be conducted utilising chronic electrode preparations coupled with selected classical types of conditioning. Studies will be conducted on the geograpAy of the brain in selected species_of_sTninvals to determine the locus in which stimulations will produce specific reactions. A careful literature survey, especially of the Russian literature)of foreign research in this area vein be conducted. Project MitULTItak, SUIOJUGIL Date Wetted: January 1961 Date Expires: January 1962 runds.current year: W. 000. 00 Purpose: To provide_consulting service and Slavic language lite�rature 106 review of Arta fcitieigu, biologicTal Saul psychological areas uthisology tasted to W. Status: The project is in its second year and is continu4r4 to produce adequately. lialPITA Sr. At F4%1:2 a o:-ii:;:tn,13. r-k--./...146. S.-11 M� _ Wt: LAIL'faritat licitZw atSce.:., -- : Volertmf_1 To ErseibLi.* � li___PvAim 49 1 ' eizo , 1, 1..w...�.1�.,....,..,, _ 1 ,-,...k.......,....."....... - 13-1.a.,...,.......-1-... /0(9 108 Addittvuzi. Autkorigaticas F., .......... a'. 4. A- 1.10:ZZaat: . AL1C.41 _ To Obli tics Covami 8.1e4t"' -, ,..2.....,............=.1,-.r.....,..--=.3m1s024..".,:elr. t 1 r -; Ir.voiqatb 3re a * ,s-.....1.,..a.I.L-c.....-,...,......._-.., 1 � ,2,:? .��441,V 4.20 �furl:et" � 012 cfer, OT; t_ At.1.0Uat VAL,. ellanc! r*Vi..4173.3 4 - : affra. , 108 3anuary_1960 MEMORANDUM FOR: untr, FINANCE DIVISION VIA TSS/13*dg.t Officer SUBJECT watuvratio Subprojsa 106. II:voice #1 Allotmset 0525�1009=d902 1. Invoice No. 1 covering the at4v"isubproject is attack:4:d. Psym.atshoa1d be made as follows: -eb beck la amount of $641.0 yabli t 07 - on-a_ Cathisria-thiTek intbsam - ask. drawn 14.00 payable drawn on 2. Please forward-the checks to ClatefTS5iebsmIc41 Divielon through TSS/Bfulset Officer b At) l'Orwiry 1360. 7h14 Is a Mai invoice. NOW.V.Ti Singe it is anticipated that additional-funds wilt be obligated for this project, the files "Weld not bit closed. Attachments: triVOICIII 6 Certifications Distribution: Orig k 2-Mdroia.o 1 - TSS/FASB 2 - TSS / CD For $ervices CERTLFICATIONS�. �041.0�000 WWWWW 0,400.15 (1)-Ills hereby certified that this is Invoice In 1pptytgto Subproject 106 of 141(ULTRAthat perfermance is satiefactory, -- Plat services are-being acconipliihed in accordance with uttlid agreements, that a detailed atienda_of_thepayments and receipts is filed IITTSS/CD. that thWbill is jtat and correct-and that pay:neat thereof has not yet been mad*. Date: ISS Chiarnical Division (2)-Iiis hereby certifted that thliTinvoice applies to Subproject 106 under 14KULTRA which was duly approved and that the project is being carried out in accordance with the memorandum dated 1,3-441,1 1933 fro aDcrloth. Din.A. And the extension of this authority i 11 subsequent memoranda. , Date: Res re Director PROPOSED BUDGET 106 Salary (Chief Investigator) $11, 500 Technical Services 2,000 - Materials_and Supplies 3,000 Travel 2, 500 Overhead (10;6%) 2;014 TOTAL� $210l4 Response_Relationship in 10 ogical Systems StateMentiOf-Funds Received and Expended iii _ _ January_l, 1961_to Deember 31, 1961 --- Grant Received $12,000.00 Expenditures: PrinciPal-Investigator___ _$9,000.00 Laboratory_supplies-and _expense 58.43 , Conference travel - Consultants 800.001 Overhead Burden 1,414.39-; Total Expeaditures 12,000.00 Unexpended=Funds, December 31 1961 I nave examined and approved the submittec expenditures. 41- Chief ISD/Biblogical -Branch-- 1 6 ltdttnna_e-Relatioaabips in IlAWcal_$yetems Itascrnt of :1%Jud..-Rys,eived aad 4ktOdad February 15 141 t,.> February_ 16;--1961 Axpenditurea:, Personne:it FrInc1pal7Inveatigatar- $ 9,000.00- , Laborstory-Terhiliejen 975.00 . '.ec.retary - - )2100 $ 10500.00 Consumeable Supplia:: itxperimental ZOriaaaliCages Feei fnu:Animeli lazuratary Sonatas 1,600.00 573.00 375.00 80000- _ Travei:' CoUference-Travel: 215T,00 rt7;vialvExplevise-Friac-ipal investigator 2-,,,375._00 CaasIt'aritJ. OverhetA Bord T:.tal.2yq:iiturctir _ Un,t.tret,ue a4e Febiu-4.-t1 ta7, exper: 3,345.0J 2,390.00 2,50001 621014.00 alppr.:,vz VA:o $31-014.00 _ -.1�1! 0--e .0.. APrii 13,-,1961 qentlonaml__ _ VAIyou wiry such for z.ha renewal of.yourigrant in tbm amount oiftWelve_tbousend7dollers ($12.000.00) to rua from Jan- uary 1, 1961 for a period-of tirOlve (12) months. Hartintb-soclosod is Out' recapitUlatioaof tbm funds received andl-tbm srpenditures under-tbm previous peat. WU ere seading-you_this_orisinal-indrnne copy but wilt_bm_bappy to forwardiaote-copiel if you so (Weirs. Very truly-yours, tnclosuras/2- (7) MEMORANDUM FOR: THE RECORD 106 21 May 962 SUBJECT : MKULTWA, SUbproject No 106 1. It is proposed to continna research und".r subproject No. 1.06 on studies of biologic�al systems with particular reference to quantifying the relationshifs between a stimulus and _ the biological-response to that stir-riulUs. Problems arising from the difference in excitability and behavioral response -among members of an animal population will be analyzed. By means of-animal prepa- rations particularly attiable for de�monstrating-specific functions, evaluations will be_made of bioIe�gical generalizations arising from - � the use of one species o animal as an experimental-Variable. A critical review will be maintain�edf selected foreign literature especially that on the neurophysiological mechanism of conditioning and related behavioral research. 2. Because of the very low level of effort on hich_this program is to be continued during the next year, reimbursements will be made directly to Mr the chief investigator, on the basis of his invoices for profeasional Services rendered at�the times that these 2--- 106 occur. No interventing cutouts will be required as were used in the previous program. 3. Fimds_required for this program for one year amount to $ ,000.00. Charges-sh-aild be Made against Allotment No, 2125-13W�3902. 4. It is notanticipated-that any permanent equipment will be needed for this program. 5. The requirement fora semiannual informal accounting has been waived. 6. All 'personnel connected with the planning and_mcrnitoring of this program-possess Agency Top Secret approval. At APPROVED FOR1OBLIGATION OF FUNDS: Date: # AY Chief, TS D/Re s earch_liranch ."? (When Filled In) No. Co-a-Account 2 106 21112 21)9o92 Object- Class Date Remarks and References Ob1igatoraii Incurred _ 11.11�� Obligations Unliquidated Liquidated Balance 25 rtA6Y2 __Mum AtAproact-106_ (When Filled In) es.mmea Distribution. Origfrol ec 2 AdAresseo - I TSD/FASS- TSD/RB I ii Ut,, flog ilLes� Romer, staL it_isAintieipated that saiiticcal-iNtaCtrill-be abliiiitS for this project, the tilos alboulti-at-tie olosetti I Attaehmentst Taoism & CertifWatice4 Distrilktions Orli 4 2 � AdAtama - ReCt 'rat /rAss 2111143D/RB :L1UNT or $ VOUCHER NO. 7-1 DESCRIPTION-ALL OTHER ACCOUNTS 12.32 DESCRIPTION. ADVANCE ACCOUNTS '� � � w � � � � :�-�:� :L 34.39 STATfON CODE CONFIDENTIAL FUNDS POSTING VOUCHER 43 40.42 , EXPEND U CODE A 47.52 S.44 001.00. PAY AU, NO. 1.10. Mei& CODE 33 $4.57 GENERAL CA LEDGER VR ACCT. NO. VOUCHER NO. 7-12 .47 ALLOT. OR COST ACCT. NO. 68.70 DUE DATE 8.1CCTI CLASSI AMOUNT 7771.7117, .777NT OR CREDIT ROME orIvERTIFirowc OFFICER: � lototco So. 2 tondo% tboiboys submjoot is 0.ttiTobe4� sbooltb as follow � � ,Teo forvorl the �boob. to Mei We *WC - thr floor by 9 limb 11961. � Ibio UO fUst tovoloo. &Woo, oiriwit Si ootialsotod � t itiost funds will to ob tea, for thio-projeat, the oboulA-not:bo olosod� � on of:Oaii , Distribution: Original h Z Addces3ee Z.TED/VAS3 TSD/Ra 106 ii 15 Xarch 1961 Vs are -004M tri*W-able to transmit tO-you_tba_follOvina tunic: ;- Thaseifunda xwpresent a contribution for-tbeivac-of your alrectora_in carrying ol�it.-tiW-If----trortery rte.:torch goals of your orgianistatiolF.-- trot, ObecksM) Toura-_truly - TO; TSS/OC act titvoice againzit _ ob1Loted fund3, _ 1, Dati, of Obligt.d.ort; 2. Ptarpose of Project?, Studies of Neurophysiological Mechanisms 3. Preboirele!,_to 4. i:spleatio4-Dato! one! _ _ P-Uoj-et-fu.-.MoTaltoi!- TIM 141 Feb 1961 MEMORANDUM_FOR: THE RECORD SUBJECT : 14KU LTR A, Subproject NcT. _106 1. � It1is proposed to continue research under_MKULTRA subproject lio,106 on studies of biological systems_with particular reference to_quantifying the relationship between a stimulus and � the biologioalsponse to that stimulus. Problems_arisiwg from the difference-ineititabilitl and behavioral response among members of an animal population will be analyzed. By means of_animal prep. arations particularly suitable for demonstrating specifWfunctions. evaluationa_will_be made of biological generalizations-arising from the use of one species of animal as an experimentaLvariable. A critical reviewlv_vill be maintained of selected foreign literature especially that on the neurophysiologial mechanism of_conditioning and relatedavioral research. 4" 2nvrTb 11 function. as cut out and cover for tkis subproject. The necessary-research will be condiTaed b th villa will submit to summary-accounting-of funds at the_conclusion of the prograLm. Any unused funds remaining at the conclusion of the program will be returned to the - 106 3. Fu de required for this program for one year amount to $12,000.00 -ATctthie Isurn must be eddek$480k0044presinting Jr I a four\ perceptservicecharge to the makg the total-amount,512.489;0W ChATirger should be made against-Allotment No. 1125=1390.39021, 4. It is nOt antpated that any permanent equentiU be needed for this program. (it -40 b)sect agreed that doumentation and accolttirig fni'lravi$1 expinses which are reimbursable by shall\conforin to the accepted practice of that organisation. 5. ThiTcrequirtment for a semiannuarinformal accounting has been waived. S. All Toersonnelonnected with the planning and monitdring of this program-possess-Agency ToiSicret-approval. 11. The project will 1,44 unclassified after_itilenv-es the APPROVED FOR OBLI. APPROVED ' � GATION_OF FUNDS: Date; , Chief TSDiResearch Branch Attachment; Proposed BUdget Distributioo; Original Only 106 PROPOSED-BUD-GET SALARY: Chief Investigator $10, 000.00 TRAVEL �1, 000. 00 INSURANCE; HOSPITALIZATION; 300.00 socIALISEICSIR IT Y ADMINISTRATIVE- EXPENSES-...�,�� 700.00 TOTAL $1Z,000.00 - 106 Cot�Aount _PAO' 4.097' Object Class Date Remarks and References Obligations Obligations Unlicgtidated Incurred Liquidated Balance g w is?�: _24rieLegw____4ZerLzi_i_a-er)gif # re/4.0e ,re.feev 14 February 1961 MEMORANDUM FORT-COMPTROLLER ATTENTION : Finasce DIvialos SUBJECT__ :-MKULTRA. Subproject 106 Under tato-authority granted is the nseroorandom dated 13 Aprii 1953-1rom the DCI to the DIVA, .ndthiextsa,tOaOf this authority is subsequeat nteasorauda. Subproject 106 has been approved asd $12.410;00TA the over-all LOW LTAA pro. Joel taids_has b44-4 obligated to cover the subproject OXI.A101011. This obligati** el futida-should be charged to Allotmeat 111S- 1390 .390Z. Chie TSD/Research Branch APPROVED-FOR-OBLIGATION OF FUNDS: Research Diretio Date: Distribution: Orig. & Z - Addressee 1 - TSD/OC �1-1.-ISD/FASS Z TSD/RB Tgn test / 114 Vat+ I 1434CSANDUN PCPs MU, FMCS DIVISION VIA $ TBDAtudest Officer star= iatimmtsujeet. Involoc#2 Allotbsat 1125-134902 1. Invoice lin.- 2 *overbid the above eabproject is attached. Payment *Mad bmeds-ai-falowes . .�Plensa-forwrid tbo *becks to Cblerp,TS0004,01r4 Draech_through TSD/Nuddit OfficarbY �1 Misrcb 1961s 3. Thle-is a final invoice. Abeam, since_it-isanticipettod that .441iti�oA1! 1,13.Ube obligated for this projeot tha filet should not be *lased. � j- Atteebeents t Inning & Certifications Distributipns Orig Al 2 0 Addressee- 1_0A'SD/FASS 106 14 Yebriaar 1941 MEMORANDUM FOR: COMPTROLLER ATTENTION : Malice Division SUBJECT : MKULTRA, Subproject 106 Usider the authority pasted le the metootaaduas-daled 13 April 14M frocis the DCI 10th. DD/As sod the exteasioa of this authority la subsegueatiaaoraade, Subproject 106 bee beta approved aad $1241/10;00i the over-all MKULTRA-pro. jest hods has beta oblit-ated to cover the subproject sageness. This obligaties of fiadelhookl he- charsed to AMU-neat mas. 1390490Z. Chief TSD/Resterth_Blitaatb APPROVED TOR OBLIGATION OF FUNDS: Dais: Distributioe: Orig. k 2 - Addressee 1 --TSD/OC 1 TSDiFASS 4----TSD/RB igen len IlA C...1. I t Cost -At&unt Object Class Date Remarks and References Obligations - Incurred Obligations Liquidated nliquidated Balance JAN "" I V'el .4 my AS dQ 2 3 1J9A 6N0 /f�f4,re IS Picsmbv 195, tatORANDU FOR; COMPTROLLER AT I ENT ION 2 Masc. D1vIaloe UWE=a 11(1,114TAA. Subproject 10$ liader t,ke aetboatity sratitod Is the merueroadena dated 13 April 1403 from the Da to the DD/A. aed_theAtzteellega of thiSiktat4ititt eulasetiteat reorooraada. 00apTeisti 106 641 heels:approved sod $21, $35.00 *I the over.o11-14KULTRA project hadi has beta obligated to cover the alibprejeci expanses. This obligati-a �Ikeda should be charged to Allot:1140 45234009-4902. /9 APPROVED- OR-081.40ATION OF FUNDS: TSII/Cheautral-DivIetou d**irch DLt�c Dietrtlauttou: 071g 1 2. Addressee t.T TSS/FASB TSS /CD T S/C (Z9Dee'59) -SECRET-, (When Willed In) CONFIDENTIAL FUNDS POSTING VOUCHER VOUCHER NO. 7.12 0 *- to ; e ta c u .4 \, . . .. . . . . . . . .. . . . . . . � .. . . . . . . . . . . . . . .. .. . . . . . -.-. . . . . . . . . . . . . . . . . . . . . . . . . . . . ..... . . . . . . . .. ED 'F.pl? ugally OR CREDIT r. 2 ..0 .., c . . . ...... . . ... . . . -�-��-�- . . . - -_ . . . ..... . . ._. . . UL... V1 '1 TOTALS 11 II 58.87 ALLOT. OR COST ACCT. NO. � _. 4 0 0 z � . � .� . .�� , � i4 4z, ,.... -4, 0. ...1 �,1 ... � .. ...'1, N . 0 w 4 0 ..5 a . w in ta ..7., z ; � , 4.) X fe 1.... S.) x ,0 4 a 0 J.- . , � 0 ID Z IP ... ,..' j � g V:i -0-- . : � WO . 0 I.,2 2 . . . >4' .. ... !Z..' � 2 . ..*. 1. i.) � ):, cc . 0. � w o es .1 V ,.. ni 0 � 4 0 e x tv 4 ), VO I. ...... , . . . . . . . . . . . . . VOUCHER NO. 7.12 7 [ SA-SO STATION, CODE POOP. NO. kO.O..11E1; * NO. . DESCR1_PTION-ALL OTHER ACCOUNTS-TT7T-1 0 et"...c c: 4 . e� ' . . ... . ' ,.-.. � � � � . , � . - . .... . . . . . - 1 1 DESCRIPTION- ADVANCE ACCOUNTS 12.27 ...� . I ,.. � . _ v. la _ 0 z _ < z ...I 4. x ta � \ . . . . 0 ' ' . ... 0.. � � � ,,,....._ . .. ri V . 7 . V , - - � le .. . V .�� IE .... -'-'- 'X. .. 1.4 ........ ---.....-.- ...... ..... � .- .. � , � �h�� .... 901 0 106 19 �7 January 1960 MEMORANDUM FOR: CHIEF FINANCX DIVISION T&S_ isciget Officer _ suancr MKULTRA, Subproject 106, I.AVOICO 11 Allotmeat 0513.1009.490Z I. Zuvotci I covering the above subproject is attached. Parr. , At should be made as follows: Cashier_ beck in the $41. 00 yable 1'2to draw* C, Ctshler_ 014. 00 payable drawn on ak. Z. -Please forward the checks to Chief. TS3/Chernic Millar: through 145Wfiud et Officer by 10 February 1960. - 3� Li atial invoice. Nowever._tince it is anticipated that addit1041 fonds will be obligated for this project, the files shoold not be closed. GrtEL K*! : Attachments: levoiee It Certifications Distribution: Orig & Z - Addressee 2 - TSS/CD of 783/Chemical Division CER r:Fy it$ KHARGE 70 lt:ER TO: TSSLCii Date of Stales of Z. Pulp� fProje et; ��..��:�� Ne-nlo-physiological Mechanisms iii11�0�41*.311110411RINgila _ nmem.oltaibmwrilietdraM11.3.1.0. MAW ta.o.wir.r.,:q.,...2.1641.1.is.see,asam2sexianc..,400x,aiwKaw 3. Progress 3624,_-*�amr � Orve-year 4, Ex pi ation Da%2Z � ....�am-aaWIN,s�ir 5. Projtet ivionitov. Dr* FROM: TSS/CD Room -B=10, � 106 February 51960 Gentlemen: We ar_a_pleased to be abli-Lo�transmit to yo* the followin funds: Tn wirer's Check wn on th or $841.00, date F drawn on t for $ 0 dated Z Feb. 1960. These_funds represent a contribution for the use�of your directors in carrying out the very worthwhile research goals of your organisation. Encl. � Checks7(Z) Yours _truly� 106 9.D*cember 1999 MEMO ANDU FORs COMPTROLLER ATTENTION i-Fietaece Divistos SUBJECT t 'AMHARA. fikbproject 104 Utder the sethority ;rooted 16-the measerauders dated LS April 1913 from the DC110 the DD/A. avd_the exteoelea this-avittortty La subseleset ratmorsedse Sehplejtsot 106 has Vesta approved ead $21.115500 of the over-a11_61KULTRA project fault has beeit-abliieted to coves the subproject espeesesi- This ohligettots of ktids shoold a. therged ttFAllorment 052901009-4902. APPRON_ED FOR-OBLIGATION OUFUNDS1 Date; I. ISS/Chemice1 D1v1s1cto Distributive: Orli Z� Addressee 99 /0C 1- TSS/FASB 2 iss1CD TSS/ CD (Z9Dec'59) 10 D_R: A F T 29 December-1959 MEMORANDUM FOR: THE RECORD SUBJECT : MKULTR-A, SUbprojec 06 1._The purpose of MKULTRA-subproject 106 is to under- take-studies on biological systems with particular reference to quantifying the relationship between a stimulusiand_the_biological response to that stimulus. The lack of a general understanding and adequate meth-odology fol handling this elationship in la realiitic fashion is one of�the major roadblocks to rapid technical progress in the fields of assessment and control of b-ehavior at the present_tim . It-is planned to utilize an interdisciplin&ry approach in thi research with emphasis on the side of the physical sciences. Several advanced mathematical techniques and physical models have_been suggested as fruitful research areas not presently being exploited. Problems arising from the difference in excitability and behavioral response among members of an animal population will be analyzed. An attempt will be made to elucidate relationships between lower animals and man by comparing physiological, biochemical, and behavioral characteristics. By means of animal preparations particularly suitable for demonstrat- ing specific functions evaluations will be 1-cal 1 I I I I I I if I I I I ill MI MI ERN generalization arising from' the use of one kind of animal as an experimental variable. A critical review will be made of selected for gn literature especially that on the neurophysiological mechanism of conditioning andelated behavioral research. Pa ticular_refere ce - ill be made-tcTthe recent shift on the part of the Russians from the strict "Pavlovian" view_to a isn ore realistic approach to the problem. will function as cutt_and cover for this subproject. The_necessary research will be conducted to the of funds it-the conclusion of the progra who Will submit summary accounting . Any unused funds remain- ing at the conclusion of the program will be returned to ,the 3. Funds required for this program for one year amount to SU, 014,00. Tb-this sum must be added $841.00 representing a four per-cent service charge to th aking the total amount $21, 85500. Charges should be made against-P-llotment No. 0515-10097-490Z. 4. It is not anticipated that any perin nent equipment will be needed for- this program. It-has been greed that documentation and accountingJor travel expenses which are reimbursable by PROPOSAL It is_propO_sed to-mount the initial phases ofielPrc _em_____ aimed at an eyentualelarifidation Of the fundamental aspects _ of the problem-Of-Stimulus -i.-response relationship_in:biolOgical systems. The present theoretiCal models -ad concepts In this area areinot-only=inadequate but also represent .roadblocks_ to further prpgress7in-the_evaluation-an4 Ce-ntrol of biological systems, including man. (See work such as Loewe) 8,--Science� 112; - pg 692, 1959) The development-of practical toele_for this work in the foMm_of_chronlc Animal preparations with pemanent-septal electrodes has-lately opened the door to effective-research-in this area. Initially the wofk will consist of a caretul_literature_survelr- especially of-the-RUssian literature, coupled with'various_clessical types of_c_Onditioning experiments uaing-the-chrenicielettroderprepara- - titans available from animal guidance programai- :Ldteirp-the -results of --- these experiments will-be pooled-With those invaying-standard:drug effects on-the-saMe preparations to-design triticalLexperiments aimed at proyiding=new_abstract models fet-these phenomena. IVisiplanned that during the first year ona_inves_tigattamcan completeitheliterature work-and'Vith aiiinimmi_ofihelpicarry out the initiaLaniMal-itudies required fOr the-designotseveraljdefinitife- ---- experimentsLto be-carried out during tbe-detend year. The form of-these experimentsicannotpresently be visualited-becauseof the inadequacies of present knowledge. /6 C

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MKULTRA SUBPROJECT 106 (22 DOCUMENTS WITH PUBDATES FROM 591229 TO 63020 6)