else? iption Date Obligations Expenditures Balance . 1 `ei ii Ai / ed , , Ilea Vs" too . - � Pf i 941.44' -- ifAila:t ti de ii , i 11 . L ' : _11 i . , � 1 i I+ II �' -41 I i I . � . -.1 - -----.1.1t a , � ; I I _ 1 r_ t , ----;.! ? i � � , I Oit1in of ?mooed study of the Metabolism of d4,yee Diethylamid. v Studies of thsL metabolism of d-lysergio acid diethylamid ILSD) are complidated by-the faot that the effective doses ars in mimosa quantities. Tagging the telecule 41Wradioactive or with _stable isot therefore assumes an extraordinary importance since Only b7 this meaae is there my likelihood of-Obtaining information ins relatively short time. The over-all-plan_vill be teLinogrporate into theimolecule suit- _ . able atoms to serve-as_tage and to administor it to experimentel_animale in WAOS* tissue; the_tagged atoms can be identified After various ti-aa ;eriods. By combining several metaods of tagging, dednotions_can,be mad* as to the fate of the intact_molsoule or_cirtain fragments of it. This approach requires_the_coordinated work of a tee.' representing experts from A number of fie1d$. Wsare fortunate enough to have-such-a-group of trained individuals representing pharmacolory. blochemittry, synthetic organic ohmmistry.-and biophysics. The individuals will-ba_named in the sections below in which-the activitiot of the first year of the .T.;rogram are desoribed in broad terms. Sznkhetie-of LSD and relaIed comipunds. The chemical nature of the compound makes it a difficult One to work with., Inowled.t;e of.the, metabolism of LsD may be gained either by studies of thit molecule suitably tagged or by studits f lysergic acid or various derivatives in which_ isotopes have been introduced at proven locations. Since the structure - - 4 of lysergic acid has not yet been completely establithed_work_will be carried forward eimultaneously on the pieparation of tagged molecules and on the total eyntheeis. Several isotopes show ;romise as possible tage-for use in the LSD molecule. Itadiocarbon (carbon 14) and tritium (hydrogen 3) are of exceptional interest because these two elements make np a /cage part of the molecule. Both canite_oataine_d_with very high specifio_activity and therefore may to-able to supp3.7 stiffiToient radioaativity so that microgram vantities can be tr-aced-in the body. Ilei.vy nitrogen (nitrogen 1$) has many advantages; b,oirever, as a ring element, ynthesising tiL into the - molecule will be en _excektioitialy- difidat feat-6 . _ _ The synthetic_ehemical program is wider the -directiori of Dr: in Chemistry. Re will be assisted by Dr. Olga. in chemistry coming from-Inn tfrand by a graduate student to The budget for the_synthetid program totals $7000 and is divided as follows:__Sakarr_for_MWM. $4500; stipend -for graduate student, $1500; expenses, $1-000 ELtAuUm.4..f_SD�ap4 The problem is to discover what the body does with LSD. The percentages of a dose of LSD retained in lnany other organs and tissues of the-body will be measured.. The pattern of excretion is important. Information as to what chemical alterations axe induced by the metabolic activity of:cells in the central P010-30 nervous gyetem or in_the_liver or in the muscle will be sought*.f.aeoanse - it is possible that_theAlinioally aotiva form is not the mOlecule that is administered, it-searchwill-te meAs for fragments of the _molecule and, then if possible abasicbody of information will be developed abont_the___ metabolism of 1Yeergio acid, perhaps by chemical studies -of related molecules. Microtschniques such-asipaptr ohromatography may prove to be important. Tbe 1414 of histological ratioantographe should be investigated. Deomams _ of the ability of thicaolecule_to produce schisophreniciaike disorganise.- tion in normal hum/mu-the concentration of 1.3D in the central nervous system viii of course have_a:prime_iatereet_. One task viii be to discover Whether concentration_differences-arist in various arts -of the central nervous system. The metaboliororam will be carried out by.D1.4_ In pharmacology. Dr. of Fbazzaoology, will be available gagliMolo bring to the problem his broad training an4-maninfrexperience in the pharmacology:of the central and peripheral nervouusystem;- Dr... of Biophysics (ihermacolog7). vho has been, active in tracer research is-to assist with the biophysical parts of the_investi- cation; this may involve epacial counters for _tritium and for carbon 14. The total budget for the metaboliam program is $18.500 and is allotted as follows: _karies. $5500. -$3000.- $!;00; apparatus. $5000; expense's, $2000 travel, -0500;- i continon y. $2000. The over-all- id6et is thus $23.500 ;1s the allowance for sity overhead. -�4 MOW= Ms TES RSOCED SMUT s Addembas to Subproject 17 and 46 1. The purpose of this addendum is to sett forth the mutual administrative responsibilities of the oodatzactor and sponsor. 2, The aims subprojects represent the research ;cognise -- of Dr. financed Amdtir ICULTRA, coming the period - of 22 October 1953 through 31 October 1955. 3. ha& recLuested the OeiversitY to � outwit to thsa a sinsaw &occulting of modes received from _the nod. Also, they repeated the return of auy unexpended bands received ter a grant to the /Nod. 4. Title to any permanent equipment purchased by fonds pentel the Unive.rsity shall be retained by.the University in lieu of higher overhead rates. 3. It was sertually agreed that documentation and accounting for travel expenses which are reimbursable by the Univereity shall contorts with the acceptedpractiies of that institution. 6. It was agreed that technical reports reflecting the progress of the research program shall. be submitted at eiutually acceptable Intervals. Golarraza Chief TSS/Chenical Division APIROVEDs A - TSS Distribution I , OrLg & 2 - TSS/C) 40imiesr. A 31 October 1954 MENCRANDITH rat THZ REMO suzu tension of Tile for Fro act 1411131,1RAt Subproject 17 � Subproject 17 expires on 31 October 1954. Lithe work has not yet been completed, an extension of one year is hereby authorised. At the present time 110 additional Audi are required. 1 APPROVE) 4.04, � -701 CERTIFICATE March 31, 1954 This is to certify that I have today re Cashier's cheek No. M139447 Alltain the amount of $748.00. March 31, 1954 This is to certify that I have today received Cashier's-,cbeck No. M13944 in the amount of omomp. 4 - FROM: SUBJECT: MEMORANDUM RECEI I hereby acknowledge receipt of the following: .1wpew e eige, CHE:C:KV-42.111461i1 17+12: OF 4; Ilrler_40 RECEIVED, �1��14M4.4.........1��,..- 1, Please retern signed copylieWof-this receipt To FORM NO. 34.16 MAR ISAR 4 � � SIGNATURE UP RECIPIENT / DATE RECEIVED 1.10/1ASIXSI Nts. oselMak StMUM � 1 Wm% 1$54 CEL17# MUMS VMS= WASSA Offie;r soprojget 177 Project =rut trottie. Alletstent lt-450240 1. Intoles 2 for Subproject 17 of Project Y.X1227,i Is ttea. this Invoice Is tbst finel exue to be pitted under Subproject 17 and sbete Pt44p constitutes complete payment of this project. It is recumteld thitt PolVeti, b* -71040 by tvo enshier's. aback. ends out to the order o A in tate aMOGOtS Of 414.07oe.00 sigliesco. -,Tto elooks-aboal be. sent to Met, TS8/040 Ural& 14*Shudget Officer by 1 April 195144, 2. The Ws Invoices eavurina this Subproject earegatte 29, 112.00 sod represent the total ezpenditrors to be node uter this Subprojest. It le�mutstedatrefortft, that flies on this Sub- project be cloyed. . 31:0=4 GMT.= Olaf Cbta4as1 Dills/cat WS Atteolvients: Sirsoice 2 - SbprGt 17 Certification. 13afent� (19 Melvb 1954) Distribution: Addresses - Ox '& 2 vie teas= Cceptroller - 1 T33/Bacizet - 1 TS3/00 - 2 /p3f4/17. I /PI, 60 CHECK#AMIAIN THE A Mr:LINT OF. $.(....f.g0.00 RECEIVED. � -a- For services rendered in commotion vith Subproject 17. Detallei brsalciown anti receipts on file in TSVCD. � .00 -411, .4 V ' - (1.) it is baraby certified that this is Invoice No. 2 applying to Subprojeat 17 of Project KTULTItig that technical perforsonce wimp 46001&if *AtteAct4011$4 tbel thd 'fork Is beim easaapliebed in 04- Utintaxioe vith the *utast egrotianot reached vith that � Olivetti is just and correct sat that paoant thereof has no yet boas Dade. � cider - (2} "It is hereby oertified Clint thia trmice applies to Dobproject 17 under Project MAMA Web use duly approved and that the ;West is beim carried out in accordance with the DWP rasorandua to ZCI iletett 3 iprit 1933, the DOI nesoranduse to DOA dated 13 Aprn 1,253/ end the DU sesoreabca to the 1,0% dated 19 .7tane 1953 Datet Research Director" (3) It filbereby eitotifie$ thet the novae the roars of Cub- projeat 17 of Projoot )4CioriZA has bus %prowl. Dates I CERTIFY 7T .77 An OBLTGATICN y�- J.To Z 4 2 �� MAR 22 11) E.-.. llmapial_tatemenA for the LSD P oject as of March 21 Salaries Permanent Materials and Supplies Travel Overhead Contingencies TOTAL Total 11321D4ttINUE1 Total' Thodiot Amount Remaining 2033.32. 9,000.00 6,966.68 1,921.25 5,000.00 3.078.75 137.09 2,000.00 1,662.*1 500.00 500.00 2,550.00 2,550.00 450.00 2,000.00 1050.00 1,13601 7,000.00 5,863.69 8,227.97 28,050.00 19.822.03 Total Received to date - Expenditures to date BALMS '1,012.50 8,227.97 11215.4? (debit) I -4 MEMORANDUM RECEIPT TO: ?SST FROM: Budge SUBJECT: Two Ii / I hereby a now1edge receipt of,ttie following: / , / Chock P1135382 in the amount of $9 350 00 and chock. IM135383 in the amount Of $37600 'Ado payable to is pi/mint for Inveico 1 1 Subproject - 17, Projoot MDLTRA� 4? 1 -, ; \\ _ Plato. retails To OAT ; signed copy(its) of this receipt FORM MO 34.49 MAR 194 SIG(ATVRE OF RECIPIENT DATE RECEIVED � 49 -F,TIFICATE � �. Novembe r 22 1933 This is to certify. thtt have today received Cashier's check No. N135383 of 1� the amount of $374.00. November 2, 1953 - � This is to certify that I have today received Cashier's check No. N135382 of � 4- , in �he amcunt of $9 35 tdber 1953 IMItA3711/41*II.0.1W, 711VCS DI713/0 C Yjatawist Issisatiet. �mats � mrevt .lavan &.arproject 17 Prod Invoirce 1 for Subprojeot.17 of Prolect WOL2A Is attached. It Is weeded that pareent be made by two csahlsr'S amok. is 'Zs amounts tre 49,350.00haa 4374.00 made Out to *becks at,Oullbe seni,t4O'hiefl-dAN3 tbxou ?s3/au&5t Officer not later than 30 Octo.Nir 1953, AMU& itiMPftreil MEMORANDUM RECEIPT ' TO: MAD FROM: Budget/TSS SUBJECT: Two Checks I hereby acknowledge receipt of the following: Check 0135382 in the amount of of $37600 made payable to 17, Project MXU1TRA. P. e* return signed copy(ies) of this receipt To FORM NO. 311.11$ MAR 1249 2 November 1953 0ATE 9,350.00 and check #M135383-In the amount as pirment for Invidoe # 1 Subproject C. .1 7'1 SIGNATURE OF RECIPIENT DATE RECEIVED W.:40MCitti CDW, mum. gnu Wrawasea. TS3/Baci4et Ofacer '- MUM Invoice rb. Mibproject. 17, Proles InvoiceNo. 1 for Subprojeot.17 of Project =TIM is a trachea.. It is requettim1 tball_pe7rarant be Ws by two craihiert4 obeoki.in the amounts of 01,350.00 ma 074.03 made Cut The 7. (:: ctecks shoe14 be seCi tolCilety CD/E7.3.4 throt.4421.4 not lrater thra5; 30 Octd14r 1953.' Attscbmente: Iravoice Certifications Distribution: Addressee 4 Cria� &1 cmptroiter . I 34ntodot - ,Jsitimparistry - 1 204431101 ROB. Blis T3-31-n 'b 2 4111.1M- 4 BID= GOTTLIEB Oder . Cbtalcral Div io, -0 (I) tt is hereby cortiti Oa% this IA Tavoicts So* 1 applying to 17 of Project MXULIVA, that technical performance Weak $ eatiefactory, taat the Voris Is being accavaikel in ceccesmce vith this mutual aaaemant readeltell vita that this bill Is at eel correct and that payment the yet bean megt� Wass � almwal"lulinnErJ 1111=741".4""1 aaphisagismi'CD C (p) -%t is hereby certified that this invoice applies to subproject 17 under ProJeot NIOLVIAvhichilts duly apprevel and that the project Is being carried out in accordance vitb the DD/Pmcmorantam to DCI dated 3 April 19531 the DOI memorandum to DD/ A dated 13 April 1953, and the De/ mcmcwandum to the DD/A dated 19 Jupa 1953. mitrch Director' (1) It Is hereby certified that the scope of the provaa of ea-Prolsot 17 of Preject-Milat has been approved, "Nolemanlefee, �\. INVOICE Fox' Services October 24, 1953 � $9,724�00 � .e, r. � � 40r, I IkellakANNIX CMIVOLIZI Mat1011s ?UMW. DiVi smscrs. Project )0=4"11As Itbvioject 17 r tbe authority wrented.to the tomoreoltet dateci 13 11 I. from tbe iczto_tbe_DIVA4 eta the furthor autiorlty pento.1 in the seatwomtat twos, 17 April 1953 frIxe tbo DD/A to the Controller subltets 'TO .46 Proleot IMULTSA44, eel the menoreatot dete4 19 Jure 1953, the XI to tho DD/A extoodint; tbs authority to cover naval Tear 1954, aJbpro,lect 17 hos been nprorel: 127,172�03 of ttot ceper-ell Project YALTA flevie b:evo tooit oblieetol to ewer the asibproct's otpeneees MOM APRIOWD AND 31DkY00111..r.Is Chief Chemical Divielont A.Pra0110 OBLICATIO2 OP . -A .�'.1":7;r"."."3aCira e.e _Ditet _ DiAributical Wressos Or & 2 1;ea'y., Zes� Bd. 3. r33/B1.31-vt 1 (4-250240) sr" TxPelistry 0,1 * -A Wei DI rvc t or .4r: MEMORARDLX FOR TES RECORD SUBJECT: Project MKULTRA, Subproject 17 - - 1. The scope of this research program is intendel_to_cover work to be done withLSD-and related compounds by �lin , at for the period ending 31 October 1954. The project vii]. be bandied through for cut-out and cover-purpoies, The proposal fr is attached to this memorandum. 2. The general object of this project is aimel at elucidation of the site and meob-�ism of 1tioof LSD by the Use of isotopically tagged molecuYec. least three major advantages will accrue from such knowledge. fixat, such data should greatly facilitate the - - development of a suitable antidote for LSD; in addition, they should wile it possible to design new compounds having like but even more bizarre activities; and finally; fundamental knowledge of the psycho- therapeutic action of drugs will be made available fox future development. has available to him attlitaiiiiiia highly competent group of scientists of international reputation encompassing the fields of physical and organic chemistry in addition to those of medicine and psychology. He plans to use ttLese people as informal consultants in the work. 4. The funds for this project include $7,000.00 for the synthetic work on tagged LSD, $18,500.00 for the' metabolic studies on such compounds, $2,550.00 for. the 1 Universit overhead-charge, a $1,122.00 for a 4% service chtirsoi.by Therefore the total cost of this investigation will not exceed $29,172.06 for the period ending-31 October 1954. Thi roject will be completely unclassified after it leave sob Chemical Division, TSS APPROVED: PROGRAM APPROVES) AiM RECOMENDED: e e Date: rman APPROVED OF FUNDS: enIcal DivisiOnvT OBLIGATION search Direc ce Date' _7- gi / Original Only Prtlett-MKULTRA;SlibprOject 17 -7

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MKULTRA SUBPROJECT 17 (16 DOCUMENTS WITH PUBDATES FROM 530930 TO 550728)