(SANITIZED)UNCLASSIFIED SOVIET PUBLICATION ENTITLED, "THE PROBLEM OF ANTICANCEROUS ANTIBIOTICS," 1957(SANITIZED)

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP81-01043R001900080003-6
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 221
• Document Creation Date: December 23, 2016
• Document Release Date: April 12, 2013
• Sequence Number: 3
• Publication Date: March 19, 1958
• Content Type: REPORT

Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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mien II. A. TAPACEBFILIA
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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pa6oTa, Hy1KHO 6bizo peLLIHTb 3a.Ratly no.nyHeHHH maccoHoro cupbsr ,?1,J151 113-
roTomemig npenapaTa 113 unt3oTptinallym, 3aa,atly, Becbma HeaerKylo, HO 1W-
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xoaeii, Mb! He pa 3 Ao.n)Klibr 6blan BCHONIIIIITb cooBa K.no,rla BepHapa: ?CHepx
ucex maTepHaabllux H B HeKoTopoil creneHH 0613eKTIIBIlbIX Tpy1UIocTefi, J1J151
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MOB meToa,HKH, OT aypilbix nplobineK yma FIJI!! OT 11eKOTOpb1X J10}1{11bIX luta?.
H /1,e1ICTBliTe..11b110,-011eIlb 60aburasi TpyatiocTb 11 comnocTb KannutiecKux ii aa-
6opaToplibix Hccqe,uoBatntil no 6lloTepanun 3.noKatiecneinibix onyxo.neil 3a-
N.rnottaaacb He TOJIbK0 11 He CTOJIbK0 B npeo,Rozemin c 6aubwoil noTepert Tpy.aa
11 Tepnetinsi 3KcnepHmetrraabHmx 3aAaH, HO 11 B TOM, 1110 oamoBpementio npn-
xoRH.nocb nepecmaTpuBarb neKoTopbie npHBbitinbie H npotnio yKopenHaumecH
npeducTaunellum o npllpoLie, cHoficmax, pa3BHTHII 3noKatiecmennbrx onyxoneiA
II npunutinax ax Tepantut. Mb! 210JI)K11b1 61.31J1 kOTIIM Mb! 3T0ro Hall He XOTHM,
pa36HpaTb 11 npeoAaneHaTb pSIA Teopungemix noamenHil ?Omer? yHemisi
o6 onyxansix, HHaHe He ouzo Ha,um.a.biFill II01151Tb
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n Ham npoTHBopegnablx, a eate Haute neyAatnibix 011131TOB.
XotieTcH oco6o no.ATtepKnyrb, HTO Mb! IniKoroua He cmorart 6bI OCNIbICJIIITb
npouecc o6pamoro pa3BIITH1 onyxoadt, ecan 6b1 He npinuall K y6exi,aelano,
HT? 3ameHaTeabHasi TeopHst MeHHHKoBa ? yHeHHe 0 3aumm0il Niaxpo-
cparoB B ee K.naccHnecKoil (Popme ? HmeeT nanHylo cm)/ 11 B onKoaorHH, 06-
JIaCTII, ra,e 3T0 yHeHne Heasoouernmaaocb 11.1111 110J1110CTb10 HrnopnpoBaaocb.
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
Declassified in Part- Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
^ Aesseme?-
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lionTH 25 .neT Ha3aA y Hac B Mocioe Hana.nach pa6oTa KOJI.T1eKTHBB Hcc.ne-
AoHaTe.neil B HOBOM HanpameHHH B o6,nacTH AenqHHH paxa ? 6H0Tep
n1111 C 1&JIbIO IICBpJ1b30BaTb AJ151 .neneHHH oripeAe.nexiibie ripoonywrbi
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/lac-rime 6bt.no IlaCTCJIbK0 C11.111111b1M, tITO 06yC.10BJ111Bail0 KJ1111111tIeCK0e BbI-
3AopoBnetitte. Magnium c 1891 r., Kaneii nmTa.ncH BbI3BaTb, B num Tepa-
mm, Hocna:ienue y 10 nauneirroB c neonepa6n.nbubrmil onyxanHmn.
BCTpeT111311111Cb C 60.11bWIINIII TpyaHOCTSINIII, KOJIen CTaJI IICTIbITbIBaTb KYJ1bTy-
pu CIpenTOKOKKOB, crepHan3oHalmbie Harpemmem iJm cpu.nurpauireu, 110
OnbITI31 6E4.111 B 1892 r. lKo.qeii,y311B 113 JurrepaTypbi, tITO
B. prOdigiOSUnl 11.1111 ero TOKCII/IbI Ch1J1h1B1OT 1311py.TICHTHOCTb Apyrnx 1\111Kp0-
60B, BKJ1101111.11 IIX B npenapaT, floJIythhLBUlhlll 113BeCTII0CTb KaK ccmemamibie
ToKcimbi Kanesp. 3Aecb pleCTHOHaTIONIIIIITb, tITO eme B 1886 r. H. (1. rama-
aes-1 Hnepabie OTNIeT11.1 JieficTime B. prodigiosum Ha paKonoro 6o.nbuoro. 1/IM
npnroTomeubt y6nTbie KyabTypbi, KOTOpble BBOXIJIIICb Heonepa6Hob-
Hofi 6armoil. Flog BAHRHIleM ,RefiCTBIISI B. prodigiosum Ha6maaa.nocb 311a-
4inenbHoe y.nytnueme ee C0CT01H1151.
MIIITO6I10J10111 113rOT0BILTIII 11J151 KaneH pig pa3J111tIlibIX MOJI.I411Kal.1.11r1
TK Ha3bIBaeMbIX ?cmewailHbIX TOKCIIHOB>>, KoTophIC 11 npnmemmucb 13 KAMM-
Ke. Karla Bcera npegnoturra.n AoKa.dbubte tutzeKtyttl, TaK KaK nalara.n, TO
3(1)11/eKT no.nytmercH 6anee 6bICTpla 11 onpeganeHHwil, gem npn nogKo>KHom
H yga.nelmom OT onyxcon HermbicKnHalum. 1-1aH6o.abwee tmc.no ycneunibix
1)e3y.nbTaT0a c onyxaimm11 pa3.i111gHb1x TIITIOB 6bIJ10 TIOJITIeHO B nep110,11, C
1906 no 1912 r., Korga npumensunicb cnablible 11 croihthe npenapant, 113ro-
T0meHHbie Tp3cn. TO.TIbK0 nocze cmepTH Ko.nefi B 1936 r. pKe Apyrne Hccne-
JoHaTe.nn Bb111C1111J111, tITO a.TI51 IlaI160.11311161 30eKTIIBIIOCTI1
KaK NIO)KHO cKopee nonagam H onyxo.nb gepe3 Kpossmoil noToK, paHbwe, nem
OHI! Herrrpa.m3yloTc1 TKaHSINIII. DTO 061aSICHFIeT nogemy impaTymopa.nbHbieii
mnpaseno3Hbie 111rbeKIIIIII BbI3bIBaIOT 6anee 6bicTpoe pa3pyweme
OguaKo npnmeHenne NieToAa KaneH, napHay c,egvninglibimn ycnexamm.
HaTOJIKHyJI0Cb Ha NiHorne Tpy,aHocrii 11 TBHbIe 'Heyaatnt. MHTepec Hpagert K
cCMe11.1aHHbINI T0KC11HaM>> nocTeneHHo num.
MeT0/1 KOJ1e51 6131.n ,ReTa.nbHo paccmorpeH D. Kaneil-Harc, Gamin' H
B Ko.nert (1946). Onn yeTalIOBI1311, tITO CO Bpemetni naga.na npnmenemin gait-
uoro meToga 13 1894 r. ncn0.nb3oBaJ1icb no Kpaitheil mepe rurpHaguaTb pa3Jam-
11131X npenapaToa , 113 KOTOpbIX TO.IbK0 TpH oKa3aallcb 6o-
oee aKTIIBHbIMII, gem ocTazbHme. TexHium npumeHeHrm npenapaTa umpoKo
Hapbuposa.na B OTH0111e111111 cnoco6a HaegeHHH ?10311pOBK11, HaCTOTbI H npo-
aalDliliTeJlbHOCTII .negemm. EXHIHCTBeHHbIll ripenapaT, K0T0pb1ii MO}KHO 6b1.110
110.71y1111Tb B CILIA C 1921 r., 6bIJI eectota cza6bni H Homily npuAtettenue
.11eT0aa 6 37'OT 1103aHeallHiel. nepuod 6bIA0 8 60.11)111UHCT8e c.dyitaee eopa3do
Ate Hee 31/0eKTU8Hbl.,11, ?edit. 8 11 p e abla y Nue e0abl.D. n 03 TOM V- TIOJI ara IOT B bI -
w c II a 3Ba m aBT0p13I - C60.71b11111HCTBO 'wager' coripememioro noKanelum
tie eude.do 3a,iteitare.dbliblX pe3yAbraros, tionyttemibtx cHatta.aal>. HayTc,
CBI* ii B. Kaiefi co6pa.nn irrom Ha6.11ogeHnii, HatumaH c 1892 r.,
nag 484 paKOBbIN111 60.1bHb1M11, 113 IIIIX notrrn no.nommana6mogeHnii npuna,a-
AemT ,a-py Kozel?. Qua 6bIJIH BK.T110HellbI TaKaKe 65 caygaeH B KOTOpbIX
nme.n11 3Ha4eHne mul)eKum, rnambim o6pa3om pom(a, BbI3bIBaBILIIIe perpec-
cum 3.110KatleCTBeHlibIX 011YX0.11erf pa3J1111-111bIX TIIII0B. Bariee gem B 88% 1,13y-
1.1eHHbIX C.ITyllaeB AllarHo3bi OCHOBIDTBaJTHCb Ha Ha,E(e)KHbIX MIIKDOCK01111HeCICHX,
pamo KaK n K.nmingecKux man pewrreno.iorimecKnx noKa3aTeaSiX.
Mb! A0.11)1{11bI naasepicHrb, trro Han6aubmee 11HCJI0 HO.TIOiKIITeJIbHbIX
c..nygaes .negeHHH no meraly Kanest nag,aeT He Ha noc.dedHue 20 ;ler. CO3-
,aaeTcsi HnegaToeme, tiTO meTog He COBepIlICHCTBOBajICH, a no kaKtim-To He-
1101-15:ITHbINI npniumam ?(1.7111 >i> B Teparmit 3J10KatleCTBellilbIX onyxaneil 'TOJIbK0
Ha TlyTFIX KituttuttecKoti aunttpuu, B TIOJIHOM oTpbme OT 3KcnepHmewra.nbilo-
oHKanorimecKnx IICC.T1e,11,0BaHlifi 11, IITO He MeHee BaNS110, Ha OCHOBe conepwell-
110 HegocTaTogHbix muKpo6HanorkmecKux pa6oT 13 06.nacTil 113ygeHnsi CB0fICTB
po>micToro crpenToKoKKa n B. prodigiosum.
Bce 9TH c...na6bie CT0p0HbI npo6.nembt KJIHHII4eCKOr0 H 3KenepHmeHTa.nbHo-
ro OCBOeHIIH KarieH HliKaK He KONIIIeFICIlp0BaJITICb
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mat man 4>apmaueHTn4ecKaH cinipma flapx, E13BHC H B CILIA H gpyrHe
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HbIX nonbrroK 11 nOTICKOB cTaHgapTHble, yCTOrItIHBbie 11 ,TIOCTaTOT4110 344eKTm3-
nue u ogHonpemeimo m111-111MBAbH0 TOKCIPHibIe 6HonpenapaTbr Tima ?cmewaH-
HbIX. TOKCIIHOB>>.
LIJIH pewemm Honpoca-nmeercsi .nn 3epH0 UCTUITht B N1H0r0t111C.TleHHbIX
pa6oTax, nocumeHHbix p0j111 CIPeTITOKOKKOBOri I1lnkeKHI111 11 eTpeTITOKOKKO-
BbIX TOKCIIHOB ripu .negeHmi ,paKa, - no Hamemy npeaamemno, 10. M. M11-
xailaosoil 6b1.qo npegnplifurro cnenHanbHoe ucc.negomme. 9Kcnepa1ewrbi
11p0BO21JIJIIICb B aayx HanpameHHHx:
1. MCCJIe4,0BaHlle ILefiCTBIHI CTpenTOKOKKOBOTO 3K3OT0KCHIla Ha capKomy
kpoKepa.
2. Mcc.ne,aoHaHlre CTpenTOKOKKOBbIX jI143aT0B Ha Ty >Ke ony-
X.0.1b. Bb1.10 IICTIOnb30BalIO 24 pa3J111411b1X mamma CTperITOKOKKOB, no.nygeH-
HbIX 113 KOHTp0J1bH0r0 I1HCTHTYT iii. Tapacemga.
143 mex npnae,aeHHbtx 011bITOB IO. M. MHXariJIOBOCI NIO)KHO cganaTb c.ne-
.aylonme BbIB0)3,b1:
1. CKapJIaTI3H03HbIff CTpenTOKOKKOBbni TOKCHH He 8.1111.Fler Ha pa3mT1e
capKON1b1 KpoKepa.
2. JIII3aTb1 H3 cmecH pairnigHbix 111TaMM0B cTpenToKoKKoa, npHroTomeH-
Iibie ITO Fpacce, OKa3bIBaIOT 3agep>KHaaiontee BJIIISIHHe Ha pamirrHe capKombi
KpoKepa.
3. Omani, ripHroTomeHHble 113 cmecn paarnigHbrx IIITaNIMOB cTpenToKoK-
1(013 nyTem JI,JIIITeJ1bHOTO ampauumamm B 6yAbOHHOI1 KyobType, 0Ka3b1BaIOT
3agep>1melimi CJI11311CTOri 060:10'1KII
minuelmma. Zahl no.naraeT, HTO BealtecTim, BbI3b1Ba101Alle remopparimeckiiii
stficpekT B onyxwmx, 11?11eHTI1tIHW C nomicaxapnglibim KONIIIJICKCOM 311,LIOT0KCIIII-
uoro alinrreHa. ECJIII ice oprami3m mbIWII npegBapirre.nbHo IIMNIyH11311p0BaTb
(onbrrbi c 3HAOTOKCIIHONI Shigella paradysenteriae Flexner, Salmonella typhi
rnurium), TO onyxwm y Tamnx MbIWerI CTa1101351TC51 Lipe3ribmailHo pe3icTeHT-
1113E\111 IC Bo3gefic-rmio cooTBeTcTimow,ero 3II,ROTOKCIIna, remopparniff B onyxo-
jinx He iia6.inogaeTcn. Hutner ii Zahl (1943) nputuan K 3ammotiemno,
TOKCII-HbI, BbI3bIBa1011.111e remopparmo B 011yX0J151X. H C13513aHHbre C KOMI1J1e1(COM
0-auTureHoB, xa.pawrepHbi ,RJI51 He.noro pima rpamorpintaTeAmmx 6awrepirri.
0,/1,110K0 He TOJIbK0 rpamoTpilHaTeabribte 6amTepn11 NIoryT CJIMIITb IICTOt111H-
KOM aIITII6J1aCTO1HbIX BeatecTB, xam 310 c.ne4,yeT 113 01113ITa C
TOKCHHONI.
3. ,O,HOTEPHHHbill TOKCHH
TOKCHH, BBe,I.LeHHbIcI B onpeganemmix g03ax, geficTiver
He To.nbmo 3agep>mimaiouke Ha pa3BHTHe nepernmaiounixcH .paxoBbix onyxo-
Jiefi y mbimefi Ti mimic, HO 11 ,gaeT no.nHoe H3.neneime y 3HalmTe.nbHoro tmc.na
110,LICHIBITHbIX )1{11130THbIX (POCKHH 11 PONIaHOBa, 1938; POCKITH II Xaciiiima,
1946; IK:noeBa ir POCKHH, 1946). )114TepHIIHbIll TOKCIIII gefIcTByeT II Ha MOH-
TaHHbre onyxwrit ,mbnuefi. B peayabTaTe .netteHmi 132 CHOHTaHHbIX onyxo.nell
79 onyxanect 3Hat111TeJ1bH0 yMeHbIIIHJIFIC13, 31 onyxanb HOJIHOCTbIO Hcnewia,
OCTaHOBILTHCb B crioem ,pocTe 13 ,onyxwrefi, yBuniniunicb TOJIbK0 9 113 132. Cy-
Lll,eCTBelPHO, tITO y .nenembix mbiwefi, B OTJIIItIHe OT KOHTp0J1b1TbIX, meTacTa-
3131, KK ripaBH.no, OTCYTCTBOBaJIII: AIRPTeplIfiHbIff TOKCHH ,ReficTByeT He TOJIbK0
Ha OCHOBHyI0 0I1yX0J1b, HON Ha meTacTa3m Kam 113BeCTHO, MbI111 11 peciwaxTep-
Hbf K AnclyrepllthioNty TOKCHHy, HO 3.noMmecTBeimo ii3meHemibie Mb111111HbIe
PM& ?1?4 ? ?? AS. ???? es. No- 0.41???????????????=...? dm? ?
OEM... we.. ? 11?1111,
moKAHECTBEI1111,11{ 011YX0011 B 31{1.11EPIIMEHTE ii 1{31111111{E
KJIeTKII CTatIOBSITCH HyBCTBIlTeJ1bHb1M11 K ,11,14TeplifiliOMy TOKCHH. M.0)K110
6b1.110 6b1 gymaTb, tITO mexamt3m ,E1,61CTB1151 TOKCHIla 113 B. ,prodigiosum ii
guilrreptifilioro Tomcma TwicgemeHeil ium, no xparme mepe, cxogeH. HO 3TO
He Tam, 14TO 510H0 BIIA-HO 113 czegyloingro COTIOCTaBJ1eHII51:
Reacreue Torccuna B. pro-
dIglosunz Ha paKoebtx Atbittlea
1) AKT111311131C AO3b1 TOKCIP111121
2) Bneawine BhI3bIl3aeT y
cocTomme, non06110e woKy
3) Ilpii 11013TOplIbIX no3ax 31:1MIleKT
ymenbumenn
4) BblahumeT 6onbwiie remopparim
B onyxonn
5) FICKp03 paKOBbIX KACTOK npolic-
X0AllT B e3yJIbTaTC itapyineinin co-
cynnuort colt onyxwm, T. C. KaK
nn.neinie wropumwe
6) B IIMMy1111ONS opraini3Nie 3d)-
(1)CKT OTCyTCTIVCT
11eliCTOUe all0Teptlai1020 TOK-
ctuia Ha paKOBba
1) AKT111311131C ,a03bI 11C TOKC111.111131
2) BBCILCIII1C He B6131.1113aeT l3U.lI-
MO
3) Ilpu 11OBTOpIMIX ,Ko3ax acinDeKT
napacTaeT
4) remopparim, KK npannao, OT-
CyTCTBIricrr
5) lia6monaenn ?nnannenno>
ytlaCTKOB 3110KatICCTI3e11110fi
TKailll
6) Ilmniyinioe cocTostime oprain13-
ma lie memo' Aeficnino na onyxwm
Talcum o6pa3om, xapaxTep ReficTimn 3T1IX TOi{C11110B Ha 3.nomagecTBeHlibie
onyxwm coBepuietmo .pa3.ra1'Ieul: B onyxognx lia6giogaloTcH gaa a3Hbix (Pe-
HomeHa.
9111 pa3alli11151 CB513a11b1, Hag,o nogaraTb c ,paIniimort ximmtlecicoil npit-
pogoll TOKCIIIia B. 'prodigiosum ii gmpTepitiMoro ? TI0J11-1-
CaXapli,a, BTOpOil?IIMeeT 6e:11(0133.710 npupoay. 3111 01IbITbI OCTaBJ151IOT OTKpbI-
TbIM Bonpoc 0 peamumt 3.noma4ecnieH1Io11 onyxwm Ha Atul)TepHritiblit TOKCHH
opraHimme, He o6.nagaloin,em Bk1,11-0BbIM IIMMyHI1TeTOM K ,11,1-1(1/TepIl11110f1 1111-
c1;eicu,tin. 1KamoBo 6y,ReT .1341151Hile aToro Tomcima Ha pamoByio 011yX0J1b 13 -opra-
mmme, He Hmelomem eCTeCTBeHlibIX cinimonortinecxux cpaicropoB 3aun1rb1 11
BmecTe c Tem nopmaemom pakom? BO3N10)KHO JUl B Tamom opratumme iicxyc-
CTBel-IlibINI 'IlyTeN1 CO3RaTb COCTOSIHIle, npll KOTOpOM paHIIMOrI ocTaueTcB TO.71b-
KO 3.n01cmecTBeHHan onyxogb, a Hopma.ribmble TKaHll 6ygyr 3a1.11,I1111,eHb1 OT
pa3pywitTeabHoro RecICTB1151 TOKCI1Ha? 3T0c1 Ham 6b111/1 110C1351111,eHbI 011b1Tb1
H. F. K.nioeaoi ii 3. M. rutiu,6ypr (1949) no .netieHmo paxa Bpayii-rhipc
KpOJIIIKOB (BbICOKO HyBCTBIITCJIblIbIX K )114TepHilHOR 1114eKII,111), npegBap1i-
TeJlbli0 IINImpunupouamihrx. DmcnepHmeHTbi noma3a.m, nTo gmlyreplifiHbal
TOKCIIH nogawmeT paaBwrne pama ,LteficTBile TomcitHa nposm-
mieTcH ilati6o.nee actmkemTinmo npti IICHOJIb30BaH1111 01ITIIMaJIbHbIX flO3. gpe3-
mepHo 6o.nbun1e g03b1, mai( II gpeamepHo maabie, 11.1111 He OKa3b13alOT iterICT-
131151, 11011 1311115110T JIflUlb B OT,I1e-J1bHbIX CJITIa5IX (oirruma.nbHasi g03a-150-200
Dim Ha xypc Hwbemu,Hfi). HalL111 3HaHH51 0 Tipiipoge pamoBbrx onyxogeri CT0j1b
orpaHimeHbi, wro He .nermo ma.matipoBaTb TOT npumenaTe.nbHbal ikawr, tITO 13
opraintame, IIMMyffliom -K. xicin-eplig.HOMy TOKCIIHy, '110CJIeAHlIcl gocniraeT pa-
KOBOrl onyxo.ini H -paspymaeT ee. He 3aTpariman Hopma.nbubtx Tmaxeci. Ha
nepBbill B31%1151,11 Ka3aJI0Cb 6b1 6o.nee .nortimbim ommtkaTb, LiTo TOKCHH B ninep-
11M-MyHHOM opraull3Nie 6yAeT CB513bIBaTbC51 CIle11114/11HeCKIIM aFITIITOKCHEOM
6ygylni Herrrpa.nmoBamibim, noTepsieT CB010 CTIOCO6HOCTb noi3pelmgaTb paxo-
Hue K.11eTKH Talc }me, mai( OH TepneT B 3TIIX yczoBlinx CTIOCO6HOCTb noBpeNi-
aaTb Hopma.nblible maim opromi3ma. He nogzexinT comHemno, HTO TOKCHH
13 ,RefICTBIITe.11bHOCTI1 OBH3bIBaeTCH aHTIITOKCIIHOM, 1160 -B HpOTHBHONI cayitae
110A011bITHIDIe >KIIBOTHbIe gOJIKHbI 6bIJIII 6bI norHoHyTb ripH THIllit1H011 mapnme
AlickTeptifmoti HHTcricenmaumi. OgHamo KpOJIIIKH He o6HapymotBaioT .HHICaRIIX
I1p1I3HaKOB 01114TepHRHOCI mrromcmcau,HH. Flonemy >me 3TOM pa3pymaioTcii
pamoBbie mnencH? Moxmo npegno.nwicHTb, 11TO Hmmyllogorrinecman peamuim,
B0311111{Illa51 B 110pMaJIbHbIX opraHax, He pa3mineTcn B onyxwm B CHTly ape-
aKTHBHOCTII, ummyHo.norunecmori 11HepTHOCTI1 pamoBbix KJIeTOK. 0,11Haxo 11 fl p11
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
1.;
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
4401W'F;I:
16
.ElEnCTI;111: PA3:11111111,1X NIIIIITOT)1114X 11P0,1Y1i1013 HA
3TON1 Aonyatemni ocTaercH HeHC/IbIM Bonpoc o TOM, RaK upoHnKacT TOKCIIII
B onyxoon liepe3 IIMMyillibIe 6apbepu, BcTpetiam na CBOeM nyni cneuncImlie-
mai alITIITOKCI111. OcTaercH ripe,anonomiTb, tITO CB 513b1BalilIe Toxcima anTH-
TOKCIIHOM ne conpoBoKaaeTcH noTepell afiT116.71aCT0N111bIX CBOIICTB TOKCIIIIONI.
3To npe,anoamemie AOHyCTIIMO Tame H noTomy, 11TO COCJI,1111e1111e OTOKCIla?
alMITOKCI111>> 51B.T151eTCH no cBoemy xapaKTepy He XIINII111eCKHM, a aAcop6unon-
Irbim, B KOTOpOM crioficrBa TOKCIIHa B ornoweinin paxoBoil onyxo:u1 ne Mena-
101051. HO Kai( 061,51C1111Tb o6paTHylo 3a1311CIIMOCTb meKay ROJIIItleCTBON1 BI3e-
;ieulloro ToKcuna 11 ero larrn6IIToplibim 3(14ewrom? Ha6moitenitH noKannia-
JOT, 11TO inirukTopHoe Aerie-rune ,InclyrepnilHoro Toxemia na paKoByto onyxcob
npeacramBeT co6oil 6no.norntrecxylo peaKuino, ,Bo3IniKalouglo II pannBalo-
ne 113o.TnipoBanno, a npli yttacTini clumcknorntlecKnx MeXa11113NIOB op-
ramr3ma. Elite B onbiTax, onlicammx paHee (1946), Mb! y6e1I11.1111Cb, 11TO 6J10-
Kaita P3C, 3Kcnipriatuisi ce.rie3ema1 TOpM035IT KailueparnmitiecKnil 311)(PCKT
6no.normecKoro npoTimopaKoBoro npenapaTa, npHocTairamilBaH npouecc
o6parnoro pannTlisi onyxamr. OrIbITI31 HOKa313113a10T, 11TO 1136bITOK TOKCHIla
ripopbmaer IININ1y1111ble 6apbephi, no/lams-1dr 3auurrHyro CIICTeMy. B VC110131151X
yrHeTenim nmmyHo6nauorlltiecKoil aKTIIBHOCTII opraHH3ma B.111151 fllie AncIne-
pniinoro Toxemia He mo)KeT 11p0FIBI1TbC51.
4. JIH3ATb1 14 (1)HJIbTPATb1 HEKOTOPM APYIHX BAKTEPHR
Cpexi pa6oT noc.ne,unero ,aecHTH.neTIIH czeuyeT BblJe.q1iTb liccae.cloBanim
(1)o.r1Abmapa ii IHez.7151 (1944), HCI10.11b30BaBWIIX B noncKax a111116aacTomnbix
BentecTB ,milKpo6Horo nponcxo>Kuelimi o6umpHylo NozneKumo 6aKTepiranb1ibix
wTaNIMOB. 011J1bTpaTbI H 11113aTbI 60J1bWOTO tincza 6aKTepuil npn6aBJI5I.Tnicb
HenocpeAcTBeHHo K xy.ribTypam 3.noxatiecTBennoil maim Bile opranH3ma 11.111
>Ke ma.neHbxne KycotIKH onyxozeil TKaHli npeABapilTeobilo nomeuta.nncb na
24-48 tiacoB B on3aTbr milKpo6oB, a 3211em 11p0B0,71,I1JIIICb Ha6JuoueHHH
pOCTOM Taxnx 3.110KatleCTBeHHbIX B yCJI0131151X Ky.ribTyp Bile opraHH3ma:
OrIblTbI noKa3a.ini, IITO 00060171 aKTIIBHOCTb10 B OTHOUIeHIIH xy.ithTyp paxoBoll
TKa1111 o6oa.amoT JIII3aTb1 CJIe,LIy1011tIlX 1151TH BI1110B: B. subtilis, B. coli, B. di-
senteriae Flexner A., Streptoc. Sg. 104, Streptoc. ovalis. 3Recb >Ke nano OT-
MeTIITb, IITO Bee 9TH OrIbITbI TpyuHo 11OBTOpIT.MbI.,4J151 upyrnx licc.neAoBaTeoeil,
TK .KaK ornicaHHbie cBolicTBa HeKoTopbm BI1110B 6aKTeplIrf HpIICy11.111 TOJZbKO
abituepcaaatatum turaAmia,u, wteiouitiAt C6011 4a6oparopubta u14p. FJepe
Hcc.ridaoBaTe.rumul BO3HHK Bonpoc 0 nplipoile BetuecTa, aKTIIBHO ,RerICTBOBaB-
MIX Ha paKoBbie KneTxn. floaTomy 6131.Tr nocTaamen. onbIT c quirurtielthem 13 Te-
l-lei-me 15 MIIHyT .111,13aTOB If (1)13.TIbTpaTOB. npII 3TOM npenapaTbi HC Tepszint
aKTHBHOCTI1 11pOTHB paxoBbix KJIeTOK, a B HeKoTopux czytragx okra Raxce ycn-
JIHJIaCb, xpome .71n3aTa B. subtilis, rge aKTIIBHOCTb ymenbumaacb. Haag Talc-
;ice yxa3aTb, tITO o6pa6oTxa KOJIII-J1133aTa peHTreHom 11 yJIbTpa111110J1eTOBbIAIII
zyttamir He yfmtrro>Kana ero aKTIIBHOCTII.
KOJIII-J1113a1 '0Ka3aJICH K aerICTBH10 euxoro uaTpa (5: 1) II
Ropmaabfrofi COJIHE0171 KHCJI0Tb1 (24 tiaca 13 TepmocTaTe, a 3aTem HeilTpaan-
3aunH). 06pa6oTxa nencHHom 11.)11I Tp1ITICHHON1 Tame He ymeHbuniaa aKTHB-
HOCTII K0JIH-JIH3aT21. Bce 3T11 OTIbITbi 00J1J1bA1apa 11 KlIe.11.1151 TIOKa3013a10T, TITO
aKTHBHbre BeluecTBa, AeficTBoBaBurHe Ha paKoBbre KJIeTILII, ire 51B.TIS1IOTC51 (pep-.
meHTamH 6aKTepnambHbix KJIeTOK, Tax KaK awrilBHoe BeLUeCTBO Bbr,u,ep)KHBaeT
KinumeHHe. floaTomy 1\10)KHO ,ILyMaTb 0 pa3aHturbix ,COCTaBlibIX 1.121CT5TX 6axTe-
pHazbHou XJ1eTKII, Totmee noxyua He onpeueaeHHErx. 143 OrIbITOB C yobTpa-
timuyrpalurerr MI:MHO 3aKJII01-IllTb, axTHBHoe BeruecTBo BbICOKOMOJICKy-
J151pHO CB513a110 C BbICOK01OJIeKYJIHpHbIA1 HocnTeaem. J4 cx213aHHomy uaao
kI06aBIITb, 11TO Bonpoc 0 ,aeficTBHH Ha3BaIIHbIX MICKpO6HbTX npenapaToB Ha
axcnepumeHTambHbre onyxcon 613111 1101-1TH He 3aTpoi-ryT B 'pa6o-re (1)ox.ribmapa
????????..
3.1101(AtIECTI3EIIIILIE 011YX0.1111 B 3KCIIEPIIMEIITE 11 HjIIIIIIIHE
17
11 KlieJ1J151, X0T51 nonaHembirt 01IbIT purr Hac, Lao Bonpoc o6 alITH6J1aCTOM-
1113IX cBoilmax TOM HHoro airrn6HoTnKa HilKaK He MO)KeT 6bITb peuleH
TOJIbK0 C 110M01111310 011bITOB C KyobTypamll anoKatiecTBeHnoil TKaHH.
CpeAn 6o.riee HOBbIX HccaeuoBannii yKa>xem Ha pa6oTy B. B. Opeilmana
(1952), KoTopmil noKa3aa, 11TO BBefigHlle HeKoTopmx JIII3aTOB 30JIOTHCTOTO
cragmaoKoKKa nenocpes,crBellito B capKomy 1CpoKepa HJIJI B6.1111311 Hee BbI3bI-
tsaer neKpo3, pacnaA H paccacbmainie 31-IatniTe.nbHoro tincoa onyxo.neff. (Diva-
Ko .rnmaTbt pa3J111t1IIbIX InTaMMOB cTainlooKoKKa o6.11aualoT pa3J1111111011 cre-
TICIEb10 HeKpoTutiecKoro FloaucaxapHuHaH cl>paKulin cTacinmoKoK-
Ka, B ?TAUT-111e OT 6e.rnmoil ckpaKuJIH BbI3bIBaeT pacnauriJill 3aAelmacy B
NIbIWIIIIbIX mummer!, oco6eHH0 3ameTHylo npn BHyTp1113e11/10N1 BBeue-
111111. ,aa.aee (1)peilma1I oTmetiadT, 11TO noancaxapaman CppaKI1,1151 CTa(1)11J10-
KoKKa o6.rta1LaeT 510110 Bmpaxcemibim Tp011113NIOM K 011yX0J1eBOri ami. DTII
AaHlible pacxo,wrcH c pe3yabTaTamH .Ha6.rnoAeHnil rpa6tieliKo H flo,an.nbtlax
(1952). 3111 npoTHBopetnui, Beposrruo, HaX0MIT CBoe o6-bsIcuem1e B IICHOJI13-
3011a11H11 pa31IbIX ILITaMMOB ,mmepo6oB 11 B ,pairminroff TIOCTaHOBKe OrIbITOB.
nO-B11/111MON1y, 3T0 3ametiamie OTHOCIITC51 IT K OTp1111,aTe.T1bHbIM pe3yobTaTam
011bITOB 3aeB0r1 (1953) no .netiefuno onyxarrert NIbIWerf ,HeKOTOpbIMIt 6aKTepn-
a,TIblibINIM T0KCHHaM11.
5. ,REFICTBHE MHKPOBH0r0 IIPETIAPATA 221 HA TIEPEBI4BAE-
MbIE H CHOHTAHHbIE OHYX0jIH MbIIHEH
B npouecce 110IICKOB HOBIAX 611oTepaneBTutrecKnx npoTHBopaKoBbrx npe-
napaToB m1-IKpo6Horo rIpolicxo>Kuentui MbI cmormr 11pIITOTOBHTb 113 B. subti-
lis Tax Ha3b1BaeMbIii npenapaT 221. YlKe nepBbre 011bITb1, npoBeuelmbie COB-
NINTH? C C. H. M.11.110BaH0B0r1 Ha capKome Kpoxepa, noxa-
sum 3Ha1IIITeJ1bHy10 34X1leKTIIBHOCTb 3TOTO npenapaTa ripH npilmeHemur ero
no o6bitinoil cxeme iicnbrramm npurnsopaKoBbix npenaparoB mirKpo6Horo npo-
ncxo>KileHuH: B Hat-lame nplummadrcsi 011yX0J1b, a cnycTH cyrxii HatanialoTcsi
inrbeKuuu npenapaTa. 3111 011b1TbI no3Banna1-i nepeilTH K ucnbrrainum npena-
paTa na CTIOHTaIIIINX onyxoJuix mbnuell, ,r1.1151 tier? 6bizir B351TbI 21 N1b1111b,
Hmesume onyxwm Becbma 60.ribunix pa3mepoB. Pe3y.nbTaTbi npHmeneHuB npe-
napaTa 221 Ha cnowrammx onyxo.nHx? onyxonil yBeoutuicb y 6 mbulleil, cTa-
6nan3upoBainicb y 6 mbiu_reil, ymenbununicb ? y 8 mbllueil.
I
1
II
N2N9.
.flepaonatiaababirt
fm3me1) oayxoair
paamep onyxoan
flanieabaocn.,
aetreinin B AIIJIX
3
8
9
2,0x1,6
1,9X1,q
a) 1,5x1,4
6)ropomaaa
1,5X1,5
ropomana
1,0X0,8
onyxo.lb itctleaaa
28
25
17
12
1,8X1,2
1,2x1,0
14
14
3,0x1,9
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5 2,3x1,6
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31
ij
2
npriassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
18
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
;11:11CTBIIE PA3.111?1111.1X 11PO1IYHTOB 1IN
Onyxo.nii, yNietibuniswilecn no BJIIIH111101 npenapaTa 221, 6biait nos-
BeprilyTbi rucTonornnecKomy myneinno. flpii AeficTunii npenapaTa 221 oco6o
BbICTyllaeT o6pa3osainie o6unipithix nanocTeil, 3anarnieniwix cepo3no-Kposn-
IIIICTbINI co,lep:Kumbim. Hapyweinin, Ho3miKalow,He B onyxanii, 13J1eKyT 3a
co6oii Ii ii3menewi5I paliOBbIX K.neToK, ymeHbweinie nAep, nueinie
MIIT03013 11.111 nonHoe 'ix npeKpauteinie. Cymmiipyn ritcTanorimecKne na6.nio-
Amin, mbl A0.71>K11b1 00060 OTNIeTIITb, tITO miiKpocKonwiecKan KapTima
ripenapaTom 221, cywecTsemio ovninaeTcn OT Toro, 111.0
onucano Hamii ,V151 onyxo.neil, no,sseprauunixcn uni3oTpiinaiiiioro
npenapaTa.
11 piieeitHbIe 011b1TbI 110J1e3110 COTIOCTaBlITb C 11a6J110)1,CIIII5IMI1 Gregori
(1950), KoTopbui noKa3a.n, t1TO 110,EI minuniem aHTH6n0TiiKa 113 B. subtilis
npolicxasiiT pa3pymeHne ?siipyca paKa?. DTOT .11POUCC Gregori Ha6.Tuoiwa
13 9i1eKTp011110N1 mimpocKone Ha paKormix ICJICTIQX in vitro. XHminiecKii H c no-
MOLIIb10 3.neKTpocimpe3a 6bi.no no.nytieno 113 3KCTpaicTa 6aKTeptiii xplicTa.n-
awiecKoe setuecTso, Ha3salmoe ?marHe3Hym TpatuniaT?. Tame KplICTaJIJIbI
Aa3a.nircb 8 60J1bHbIN1 c xi,a.neKo 3awep,w1im paKOBbIM npou,eccom, npunem
11a6aio,Ra.1och Kainnitiecime y.nytimemie.
6. BJIHNHHE BAKTEPHOI:DAIA HA 3J10KAtIECTBEHHNE
OHYX0JIH
3a noc.ne,smie rum Hcc.neAosaimn rio npoTllsopalCOBLANI aiiTH6H0TiiKaNi
OXBaTILIII He TO:1131(0 pamipmbie sirAbi 6aum.n.n, Ho H3y4einno 6bum nalsepr-
IlyTbI 6awrepilocpar it .Apyrile
ilposoAn 3KcnepHmeHTbi c Kar11-6aKTep1im1aro1, BJIOX (1940) NIOr 3a-
MeTIITb, tITO (par coxpaHneTcn B TKa1151X MbIIIIIIHOr0 paKa ii Kypimoil capKombi
uo.nbuie, nem B Hopmanbubix TKa11151X, nputiem .HeKoTopue onyxwm Tepsimi
cnoco6HocTb K noane,spountm nepesusicam. 0,siraKo Kox (1943) He Nior 110A-
THepallTb 3TII lia6J11011,eH1l 51. B TO ?Ke spemn (Do.n.ribmap ii Klie1111b (1944) n3y-
'iai Ko.nii-6axTepHoc1)ara Ha Mb111111HbIe onyxanu, nputu.nii K
tITO OH oKa3bisaer Topmo3nmee RefiCTBHe Ha paKouy1o4 FLO HaiseNiy
npemmeHmo, JO. M. nixaii.nosa nposana ricc.noxamie AeficTinin ,a,H3eH-
Tepiifilioro 6aKTepHo4para (nanytieHHoro 113 IfIlicTiiTyTa lIM. MetimiKosa) Ha
capKomy 180
110/1.011bITHbIM mbnuam B Tenemle 10 AHeil, Hamman CO XI 51 iipii-
BliBKII onyxwm, BBOR1111C51 An3eHTep1Iruibirt 6aKTepHo(1ar B Ao3e 0,2 AM B 06-
JIaCTb, oT,sa.neimylo OT MecTa npitruisini capicombi. 01113ITbI 1103B0,111.111
ICI. M. MIIXailJ10130f1 csg.naTb aneRyiounie BbIBORbI: 1) nos. 13J11151HIleM ,1u13e11-
Tepiirmoro 6aKTep1loci)ara Ha6,n1aaaeTcn 3a,aepicKa B ipa3ptrrim capKombi, azt-
itaKo OCTaHOBKII pocTa onyxwm He Ha6mo,s,aeTcn; 2) 1111aKTHBIIPOBaH111b1i1 Te:1-
aom 6aKTeplio(Par He oKa3b1saeT Topmonmero Aerie-min Ha paniiTHe capKo-
MIDI 180. K 3Tomy MbI AO.TI)KFIbI rippi6ailliTb, tITO 13b1B0AbI H3 pa6oThi 10. M. Alm-
xail.nosofi He moryT orpammusaTbC5I npocToll KoHcTaTauHeil 3ameTHOr0 11H-
rHORTopHoro 3(1.A)eKTa Ha onyxanb. KaK 113BeCT110, 60J1131110e tHICJI0 BeUleCTi3
Pa3H0n npHpaabi OKa3bIBEICT B TO HMI liHOriMepe noRaanniontee
,ieficTsHe Ha 3KcnepHmeHTazwibie onyxo.nH. 0,s,HaKo, eCJIH NIbIcTaHem Ha Toil-
Ky 3petun1, nTo 6aKTepHocpar SI13.71 5IeTC51 )1(11BbIM Cy111,eCTBOM, TO Bea, sonpac
iipeacTaiieT nepe,a Hamn B IIHOM 6anee 3Ha41-iTanbHom Hue, Talc KaK B 3TON1
anynae Mb! nassxamm K OAHOil 113 r.ny6otiactunix 6Hanormecinix npo6.nem ?
K Ilpoozeme 6Hanormiecinix aHTaroillicTos, BHC 3a131ICHMOCTII OT Toro, Kr.K
Mb! nwKanaem 3TY npo6.nemy paccmaTpHsaTb: KaK npo6nemy auTarowi3ma
menusy 6aKTepHockarom paxoHoil memoti WIN KaK npo6.nemy atiTaroint3-
ma me)Kay rHnoTeTnneciulm isHpycom paKosoil onyxwm ii 6aKTepHogmrom
HecmoTpn Ha 60,nbume TeopeTiNecKoe, a BO3M0)KHO 11 KoHHHnecKoe 31Iat1e-
Hite pa6oT c 6aKTepHo4mrom XIJ151 OHKOTIOrHII, 9TH Hcane,aosainin TOJIbK0 Ila-
tIaTbI.
3.101cMIECTBEHMIE 011YX0:111 13 DIICIIEPIIMEIITE II liJIIIIIIIKE
19
?
7 BJIHRHHE HEKOTOPbIX BHPYCOB HA 3J10KAIIECTBEHHblE
1
?
OHYX0J1H
-
Ew,e JleHnuiTii ii 1-111Kanay (1922) noKa3a.nii, tITO iieKoTopbie supycbi
()KanToil mixopaaKii, BaK11,1111b1 Kypiiiioil qymbi) NioryT 11361ipaTanbilo co6n-
paTben B 011yX0J151X. ,apyrIle HcaneitoHaTanit yCTallOBIIJIH, tITO (pihnbTpyioume-
siipycbi MoryT iiinilliumposaTb 3J10KatleCTBeHilbIe onyxwm II cymecTsosaTb
13 IIIIX AJIIITeJlb110e BpeM51. DTO 06CTOSITe.11bCTBO 1103B0J151eT Lyman), tITO 3J10-
NatiecTpentible KJIeTKII He cnoco6iibi shipa6aTbniaTb iimmyiniTeT K pnity ciniabT-
pylowiixcn impycos. FlpucyTcTslle Hanaimbix siipycos B OrlyX0J1eBOil TKHhI
Ile satineT 3ameTno Ha pa3sHTHe onyxanii II, no-simumomy, >K14311b 331o1U1necT-
BefIllblX K.neToK ocTaeTcn 6e3 KaKIIX-J11160 3aMeTlIbIX 113MelIe1111i1. 03,11aK0 B
eBoehi pa6oTe-311,apioc (1940)
yKa3bmaeT, tITO B pe3yribTaTe ripticyTcTsim B
011yX0J1I1 mipyca pa3mHomeime paISOBblX. KJ1eTOK MO)KeT 6b1Tb HeCKOJIbK0
yriieTelio. MOCKOBCKIlil iicanasosaTanb P. 'lieu (1949), mytian npo6.nemy
CHM6H03a siipycos co 3.noKanecTseinibmin onyxannmii, yurailosima, tITO Bitpyc
moT.naliscKoro 3intecparniTa aKTIIBII0 pannio>KaeTcsi 13 CapKONIIIbIX ICTIeTKaX
MbILLIH II npli 3TONI HeCKOJIbK0 cHmKaeT npaninkepaTimiyio C11OCO6HOCTb 011y-
X0J111 npu inoanepsylounix nepesimax caen.iim MbiWaM. BlIpyC amepiiKaHcKoro
3n1&ecim.ruiTa pa3muommeTcn B CKOMIlbIX II paKOBbIX Ol1yX0J151X Mb1111H, HO
He ?npernacTsyeT ,ambileihuemy panwrino onyxann.
P. Men tITO no,a aninumem B1IPYC B capKomiibix palm-
BIDIX onyxannx palm nuneinin pacna,sa; imor,s,a HacTynaeT
BaKyanu3amin H cinincaeTca cTenenb oKpaunisaerdtocTH onyxanempix K.neTox.
OxiaKo pn,som c Aereirepanism:inni memamii IINIe1OTCH xopowo
coxpamiouniecn inoKanecTsemibie KJIeTICII, NIHOrlIe 113 JINX ? B COCT051111111
aKTIIBH0r0 RaneHini. K 3Tomy P. Illex ,ao6aanneT, t1TO ninicyTcTinie sHpyca B
011yX0J1eB011 TKa1111 He BbI3bIl3aeT, KaK npasmo, BOCI1aJIHTeJ113HbIX 51BJ1e1111i1.
TypHep ii MHJIJIIIKeH (1947), noRpo6Ho 113y11HB .BJ11151111Ie sHpyca ocnbi
Ha capKomy 180, xanaioT Asa OCHOBEbIX 'BbIBO,Ra: so-nepubix, ocrieHubiri Hilpyc
mwKeT 06.1IaAaTb Cp0,11,CTBOM K 3..noKa4ecTseHHoil onyxo.nn, II B
npeite.nax onyxwm OH ,moxceT 11,0CTIlraTb BbICOKOrl KoHu,eHTpawm, coxpaH5110-
MefiCH B Teneinie Heo6bniailiro npoiko.n>KaTanmoro spemenn, He Hasocn one-
inis,noro sparw xo3suniy; BO-BTOpbIX, inoane nepecalum OTlyX0J1b C 60J1bLIIIIM
KOJIIItIeCTBOM Bripyca pacTeT mexneHHee, mem. 3T0 6bIBaeT 06bIt1110. LITO )Ke
KacaeTcn pa3MHO)KelIIISI sHpyca B Heon.nacTiniecmix meTKax, TO xopowo II3-
11eCTHa CIT0006110CTb sHpycos KoHu,eHTpHposaTbcn B 6bicTpo pa3miiwKsionnix-
CS! Hopmazwiroix TKainix, 3pe.nbix. 11 3M6p11011a.11bHbIX.
21a.nee Haso yKa3aTb, tITO supychi rpHnna H repneca (Moor, 1949), He-
cmoTpn Ha TO, WO OHM ,11,efICTBIITeJIbII0 MOT 1I36HpaTe.ribito co6iipaTben 11
cyinecTsosaTb B 3J10KatleCTBeHHbIX TKI1H51X, 1Ie OKa3b1BaTOT JI,OCTaT011 HO 3ameT-
Horo BJ11151H11 51 Ha pocT H pa3s11T11e aKcnepHmeHTa.nblibix onyxaneii. Cosepmem-
110 "'Hue pe3yJIbTaTb1, tIeM B BbIWel13,TION(e1111bIX pa6oTax,, 6unii no.nyneribi B
011bITaX (r. POCKHH 11 A. BaHar, 1950-51), Kor,s,a NIbI11111 C ripmniToil capKo-
ma 180 6b1.nu 3apawelibi supycom ,LIa.11bHeBOCTOtIHOr0 3HualmnuTa. M.b1111am
Ha ane,Ryiounici noane nepecaT,KH onyxwm BBOMIJIaCb sHyTpH6pioiniiH-
HO 3apaHee orrHTposamian cy6.neTaabHan Ao3a Blipyca Aa.nbxesocTotmoro
3Hu,e(paniiTa. DTH OrIbITbI 1103BOJIHJIII yeTallOBHTb CJIeviow,ee:
1. BHpyc fisa.T1bHeBOCTOgH0r0 3Hue4)ainiTa 113611paTellb110 KoHnexTpuipyeT-
:.,4
-.I C51 B 3.TIOKat1eCTBeHHbIX 011YX0J151X.
9 1-10,E( 13,1111H1111eM sHpyca npoucxasHT pe3Koe nods,aszeHHe pocTa OfljXO-
Jreii rUifl 1IX non-roe 1Ictie3HoseHHe; TaK, HaripHmep, 13 0,LIHOM 113 011b1TOB 113
15 HpliBirrbIX capicom onyxwm 3ameTHo paamunicb B WIXOM CJIytlae, B 7 'any-
tianx ? JIMeJIII e?RBa oripe,sarmmbie p33mepiDi maJteubKoro 3epria (sec 11X
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
1
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
18
41???????111??
?????????? "MM..
./EfICTBIIE 13A3.1111111.1X 3111EPOIIIIIAX TWO1IY1T013 IIN
Onyxo.nn, ymenbmnawnecH no BJ1115111I1eNI npenapaTa 221, 6boll noa-
BeprHyTbt rncToaornnecKomy H3y1e11nuo. lipit 1leriCTB1111 npenapaTa 221 oco6o
nucTynaeT o6pa3oBaHne o6untpnbix 110.TIOCTert, 3ananHenubix Cep03110-Kp01351-
IIIICTbINI co,u,epHombim. HapywennH, 13O311IIKa1011111e B onyxann, n.neKyT 3a
co6oli ii n3meHen1o1 paKoabtx N,neToK, ymellbwellue i.LIep, naAeHne tIHC.Tla
NII1T030B u.nn name nx npeKpanienne. Cymmupyn rucTo.nornnecKne na6.nio-
ACIIIISI, )1,0J1}KlIbI 00060 OTNICTI1Tb, tITO mnKpocEornmecKaH KapTnua
IlexIe1111b1X npenapaTom 221, cyutecTaeHHo ovunmeTcH OT Toro, HT?
onucallo unlit Ansi onyxaneil, nojaaepraaninxcH ,aeilcTamo unmoTpnnannoro
npenapaTa.
npuBe.leturbre 011131TbI Hawn? COTIOCTaBlITb C Ha6.rnoileHHHNut Gregori
(1950), KOTOpbIr1 noKa3a.n, nTo no,a Bj11151H11eM aFIT116110TIIKa H3 B. subtilis
nponcxo,anT pa3pyweHne ?anpyca paKaY).-3T0T .npouecc Gregori Ha6.rno/ta.n
B 3nexTpointom mnKpocKone Ha paKOBbIX K.neTKax in vitro. XHmunecKH c
MOI1.(b10 3.neETpocpope3a 6bi.no no.nyneno 113 aKeTpanTa 6anTepHii KpncTa.n-
.711IIICCKOC BellieCTBO, Ha3aaHHoe ?marHe3Hym TpausHllaT?. TaKue KplICTaJIJIbI
Haaaancb 8 60JIblIbINI c ,aa.neHo 3aluemunm paKOBbINI npougccom, nputlem
na6inoAa.riocb HAHHHHecxoe yaytnnenue.
6. BiTIHRHHE BAKTEPH04)ArA HA 3J10KAIIECTBEHHblE
OnYxotnH
3a noc.ne,amne r0)1,61 HccamonaHHH no npoTnnopaKOBbINI aHT116110TIIK3M
oxnaTnall He TOJIbK0 'pamittuibte 1311Ab1 6a11,11.11.11, 110 113yge111110 6blJlII no.lacpr-
HyTbi 6awrepumpar 11Apyrne aHpycbd.
1-1poaoxi 3KCI1epIINIeHTb1 C K0zn-6aKTepHo4)arom, BJIOX (1940) Ntor 3a-
MeTIITb, wro (Dar coxpaHHeTcH B TKaH5IX MbHflhIHOrO paKa 11 nymmoil CapKONIbI
HOJ1bIlle, geN1 B Hopma.ablibix TKaH5IX, npmem neKoTopme onyxo.rm TepHint
c1oco6HocTb K 'nocze,aytouttim nepeanaKam. 0AnaKo Kox (1943) He Ntor 110J-
TBepAIITb 3111 Ha6JuoaeHHH. B TO ?Ice apemH (Domabmap H KHeznb (1944) 113y-
nasi HelicTaHe Ko.nn-6aKTepnocpara Ha MbiU1Th1 onyxoan, npinum K ?BbIBOAy,
1110 OH oKa3b1BaeT Topmomu,ee ,ReficTnne Ha paKonyio TKaHb. no Hamemy
apeA.nmeHino, TO. M. Muxafl.noaa npoae.na Hcc.ne,Roname f1eriCTB1151 A113cH-
TepnilHoro 6anTepnoOra (no.nyneHHoro 113 MucTirryra Hm. Metnnixona) Ha
capHomy 180: no,konbiTHbim mbiulam B Tenenne 10 daHeil, HantmaH co Ansi npu-
BIIBKII onyxarm, BBOJIIIJIC51 An3eHTepurnibtil 6anTep1'1ocpar B ,!1,o3e 0,2 At./1 B 06-
Haub, OT,E1aJIelifly10 OT NIecTa npHanBKM capKombI. 011bITbI 1103B01111,111
10. M. Mmail.HoHoil ce.HaTb cze,u3noinne BbIBO,RbI: 1) 11011, Aneti-
repuilHoro 6aKTepHo4kara Ha6.1noAaeTc5l 3a,aeNKKa B ,pa3pirrum capKombl, o,;t-
HaKo OCTaHOBKII pocTa onyxo.rul He Ha6,ino,RaeTcH; 2) imaKTlinliponambni Tc.1-
Aom OaKTepllockar He oica3bumeT Topmonatero RerICTB1151 Ha pa3BIIT1le capxo-
MIDI 180 K 3TOMy N1b1 J:10J11KHIDI npn6aHHTb, tITO BbIBO,LIbI 113 pa6oTbr 10. M. MII-
xail.nosoil He NIoryT 09paHIPIIIBaTbC51 TipOCTOr1 KoHcTaTauxeti 3amentoro 11H-
rit6wropHoro 3c14eKTa Ha 011yX0J1b. KaK 113BeCTHO, 60.T1b1U0e tinc,rio nemecTi3
pa3Hoii xuminiecKofi npHpo,nbt OKa3bumeT B TO1111J111 WW1 Mepe no,aammontee
;IeficTane Ha 3KcnepHmeHTaabHble onyxo.nn. OHaxo, ecoll Mb! cTaHem Ha T01!Ky 3peHHH, tITO 6aKTepilOckar 5113.11HeTC51 NCIIBbIM cyluecTaom, TO BeCb nonpoc
npeacTaHer nepeit Hamn B itHONI II 6o.nee 3HatIIITejIbHONI BH,ae, Tan Kax B .3TONI
c,nynae MbI TIOAXOATIM IC oaHoil 113 my6oHailumx 6no.nortinemx npo6,nem ?
K Ilpooneme 6Ho.nornnecKnx aHTaromucToa, BHC 3aBIICHNIOCTII OT Toro, KaK
NIbI no-/Ke.naem aTy npo6.nemy paccmaTpHaaTb: naK npo6.nemy anTaromuma
moKay 6awrepllockarom n paKonot1 noeTKofl Han Han npo6Jiemy aHTarom13-
ma mexmy rnnoTeTnnecimm ,napycom paxonoil onyxann H 6aKTepHocbarom.
HecmoTpH Ha 6o.nbume TeopeTnnecKoe, a BO3N10)K1I0 HaHHHHecxoe 3Hatie-
Hue pa6oT c 6aHTepHo4arom AAR omc000rim, 3111 IICCJIe10Ba111151 TOJIbK0 na-
HaTbi. '
3J101WIECTBEIIIIb1E 011YX0J111 13 DHCHEPIINIEHTE 11 KJIIIIIIIKE
19
7. BJIHSIHHE HEKOTOPbIX BHPYCOB HA 3J10KAIIECTBEHHblE
OHYX0JIH
Due J1ena,anTn 11 1--InKonay (1922) noKa3a.nn, LITO neKoTopbie ampycbt
(?Ke.nToil ouxopa,a,Ku, BaK111111b1 Kypnuoil nymbt) NIOryT 113611paTeJ1b110 C0611-
paTbo1 B onyxansix. ,I1,pyrHe HCC.11e,11,0BaTe.11H ycTanoanou, HT? 4mnbTpylounte-
051 anpycbi moryT 111U11111.1,11p0BaTb 3J10KatleCTBeHlIble onyxann ii Cy111,eCTBO13aTb
B III1X 11,J111TeJ1b110e apemH. 3TO 06CTO5ITCJIbCTBo 1103B0J151eT AymaTb, HTO 3J10-
NattecTpeititme KJIeTKII He c11oc06Hbr ab1pa6aTbmaTb nmmyuHTeT K pH,ay CIHIJIbT-
pytoutitxcst anpycoa. lipmcyTcTaHe 113BBHHbiX nupycon B onyxo.nenoil maim
He ,BJ11151eT 3ameTno Ha pannTHe onyxann ii, no-mmumomy, Hth311b 3,no1CatiecT-
K.neToK ocTaeTcH 6e3 KaKnx,n116o 3aNleT1IbIX H3MeHelIIifi. 03,1IaK0 B
CBOeri pa6oTe Dimploc (1940) yKa3bmaeT, tITO 13 pe3yAbT13Te npncyTcTaHH B
onyxo.nu allpyca pa3mno?KeuHe paKOBbIX KJIeTOK MO>KeT 6b1Tb IleCK0J1b1C0
yrneTeno. MOCKOBCKIir1 Hcc..ne,aoaaTe.nb P. Men (1949), u3yna1 npo6.nemy
CHNI6H03a BIWYCOB CO 3J10KatIeCTBelillbINIII onyxonsmu, ycTauonn.na, trro aupyc
moT.naiLacKoro 311u,e4nnTa aKTI113110 pa3N1t10)KaeTC51 B capKomnbix K,neTKax
N1b1W11 II npH 3TONI fleCKOJIbK0 CHII/KaeT npo.rnakepaTnanyio CTIOCO6HOCTb 011y-
XOJIII npu inocauwioulnxinepanuncax cum ii M mbnuam. Bapyc amepnKaHcKoro
anualmmiTa pa3m1Io)KaeTcH B capKomnbtx n paKoabix onyxwmx N1b1WII, HO
ire .npensiTcTayeT AasnbHefiwemy pa3BHTH10 onyxwm.
P. Men na6.ruoaana, HTO noA nansumem allpyca B capKoNnmix n palm-
BbIX onyxannx palm HatninaioTcH Hmenun pacna,aa; miorAa nacTynaeT
naKyo.rtu3au3ln H cinoKaeTcH cTeneHb oKpaumnaemocTH onyxo.nenbtx KaeToK.
OAHaKo puom c AerellepaTimbinni mencamn IIMelOTCH B II3O6MJ1IIFI xopouro
coxpaHnaumecH 3JI0KatIeCTBeHHbIe KJIeTKH, mHorne 113 HHX ? B COCT051111111
aKTIIBIi010 ,a,e.neHHH. K aTomy P. IIIeH Ao6aa.n5IeT, TITO npHcyTcTane aHpyca B
onyxameHoil TKaH11 He BbI3bIBaeT, KaK npanHao, BOCTIaJIIITeJ1bHbIX Haaennil.
TypHep H MI1JIJIHKeH (1947), noApo6Ho anyinn3 .13J1I1511-111e aHpyca ocnbi
Ha capKomy 180, ,ae.naioT Asa OCH01111bIX 'BbIB0/1,a: zo-nepabrx, OCrIeHHbIfi anpyc
mo)KeT o6.naAaTb 3HatHITe.11bHbINI cpo,acTnom K 3.noKanecTaeHHoil onyxarnt, B
npe,aeoax 011yX0JIII OH ,mo)KeT ROCTHraTb BbICOK011 KoHugHTpau,HH, coxpamno-
tueficH B TeneHne Heo6bmailHo npofi,omKnTe.nbHoro apemem, HanocH one-
BII,RHOtO Bpeaa xo3H1IHy; BO-BTOpb1X, !mute nepeca,aKH OT1yX0J1b C 60J1bWIINI
KOJIIIIIeCTBONI mipyca pacTeT memeHHee, nem 3T0 6bmaeT 06b1'1Ho. LITo >ice
KacaeTcH pa3mno?KeHnH aHpyca B Heon.nacTinlecimx Kamax, TO xopomo 113-
BeCTHa C110006HOCTb ampycon noHiteHTpHpoaaTbcH B 6bICTp0 pa3MHO)KBIOIII,I1X-
'HOpMaJIbHbIX TKal-151X, 3peab1x H 3M6p11011a1IbHbIX.
Lla.nee Ha,ao yKa3aTb, tITO ii aHpycbi rptinna repneca (Moor, 1949), He-
CMOTpil Ha TO, WM 01111 ,IlerICTBHTeJIbH0 moryT 1I36HpaTe.nbHo co6HpaTbcH H
cyntecTnonaTb B 3J10KatleCTBeHHbIX TKaH5IX, He OKa3b1BaIOT )1,0CTaT011110 3ameT-
HOTO BJ11151H1I51 Ha pocT 13 pa3aHTHe 3KCIlepHNIeHTaJ1bIlbIX OrlyX0Jlerf. COBepWell-
110 Hnbie pe3y.nbTaTbi, Hem B Bb1Wel13J10WeIII1b1X pa6oTax, 6bian no.nyneubi B
011bITaX (r. POCKIIH II A. BaHar, 1950-51), Kor,a,a 1umn C TIpTIBHTOr4 CapK0-
N1011 180 6b1J1n 3apa)KeHbI 131IpyCONI ,ITaJ1bHeBOCT011110r0 3Hitecl)a.rniTa. MbILLIam
na umayloumil ,aeHb nome nepeca,ELKH onyxo.nn BBOXIJIaCb aHyTpll6plot11-1m-
3apaHee OTT1lTpO'BaiHtIa51 cy6.TreTa.nbHasi ,E(03a BHpyca ,ambHeaocTotmoro
3Huecpa.nnTa. DTH OrIbITbI 1103B0J113J111 yeTaHOIMITb cae,a3nomee:
1. BHpyc Aa.nbHesocTonnoro am.tecbanHTa 113611paTeabHo ,KomieHTpHpyeT-
CR B 3JI OK attecTseH H bI X 'onyx OJISIX
? 2. nu anHHHHem aHpyca nponcxo,auT pe3Koe nop,aaneHHe pocTa onyxo-
nell Will 'IIX no.nHoe HcHe3HoaeHHe; TaK, Hanpnmep, B 0,11,HOM 113 OT1bITOB 113
15 11p1MHTbIX capxom 011yX0JITI 3ameTHo pa3anaHcb B 04,110N1 CJIytlae, 13 7 coy-
Hanx ? Hme.nn una onpeAarnimme pa3mepbt mazeHmoro 3eptra (nec MX
2*
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 ? CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
???????? ????????????????? ?
20
PA3311,1111,IX 3111KPOBIILIX 111,0,1Y1TOB HA
K KoHIy oribiTa He ripeBbiwaa 0,02-0,05 e), a y cemit Mblwe ? oTcyT-
CTBOBa.111, B TO BpeNiti KK B KoitTpoae onyxwni pocan itopmmbno.
3. UeIICTBHe Bitpvca AaabmeBourotmoro situ,e(1)a.niiTa Ha onyxwm 3aBit-
CUT OT BBeLeHuou f103bI 1101OTIbITHONly JKIIBOTHONIy: TOJIbK0 maccumtble. (cy6-
:ieTa.T11311ble) )1,03b1 OKa3b1BalOT tieTKo Bbtpa)meHtioe npoTimpaKoBoe ACIICTBI1e.
4. Tio21 B.111121111eN1 Bilpyca 13 KneTKax onyxoneil nponcx0ABT ray6oKne ril-
crotim3i1wor1It1ecK1ie 11 UJITO.T1011111eCKIIC H3meHemitt.
Bo Bpemtt npoBeJeinist 3T010 utcC.leJI.OBaIlIl5l Mb! CNI017111 0311aKONIIITbC51 C
pa6OTOil AaulcbI Myp (Moor A., 1949), KoTopati nocae ,Itatirnx 11101ICKOB BII-
pvcou. anarottucTirreciut JeficTBytownx 'Ha onyxo.trit, npituma K aHaaorittinum
C-IlaN111 pe3yJIbTaT1NI: Biipvc ,TIaJ1blICBOCT0111101'0 311u,e(paairra 113611paTenbito
pa3pvinaer 3.10KattecTi3eHHbte KJICTKII. 0/11-1a10 B onbrrax Myp aKTI1BlibINTH 6E-
011 TOSIbK0 .1CT3.11311bIe ,:103b1 mipyca. a cy6neTa.ribitbie )103bI coBepineinio He
BJ111 HjIll Ha pocT capKombi 180, B TO Bpema mix MbI moral' ilta6.ritoAaTb e3K0
BbipmeHitoe no,RaBaemie pocTa ti fl1l BBeReHIIII cytItteTaablibtx )103 Bupyca.
,aaJlee Myp VCTaH01311J1a, tITO BBeae111113111 noB,Komo NIb1111aNI wipyc nosum51eT-
051 citatima (npirrom B BbICOK0r1 Kom.tempaunii) B Orly:Wall; 3aTCNI iepe
5 Atieil Houle 3apa)Ker1m Bitpyc xot-iu,eirrpHpyeTcst B paBHoil Niepe H B ony-
X0.111 11 B A103ry. B cepim pa6oT Myp (1949, 1950, 1951, 1952) no)1po6Ho itc-
c.tieztoBa.ria BJ11151111ie AaJ1bHeBOCTOtIHOr0 amtegmatiTa Ha mitortie BlIabi TpaHc-
nzatrriipyembix onyxwiefi. DTOT Bupyc pa3pywaeT He TOS1bKO capKomy 180.
M3 13 pamirmix onyxo.neftn0.11HOCTbIO pa3pyluanticb onyxwiti 5 Timm
1) g1!6pocapKoma MCI, BbI3Baln1a1 MemaxanauTpeuom; 2) afigHoKapwitto-
ma matiolnibix )Kene3 E0771; 3) capKoma F241; 4) imputmoma 1025; 5) oc-
TeorettHast capKorna PHABail; 6) ,Heilpo6nacToma C 1300. Ha atimtl)ocapicomy
it 2 mamma .neilKemiiii Bnpyc Aerie-I-Bonn coa60, a Ha ocTasibitbie 5 onyxo-
zefi (rnezaHoma rapaintra-Flaccii, capKoma Ma 387, tieinyiltiaTomeTotmasi
Kapu,imoma, capxoma BarHepa) He AeficTBoBaa comem. Flepettitc.riemibte
MITb onyxoaefi pa3.rnitiaJmcb B TOM, tITO ,11,J151 HeKoTopmx Tpe6oBamicb 60JIee
3HatIIITe.T1bHbIe KootriecTBa wipyca, Tro6bi A0611TbCH yHIPITO3KeHITH onyxamt.
Myp ninueT, trro nprigiiHa pairnitmoro ,aeficTwin Ha pa3Hbie onyxwm noKa
.....???.???????Mar
3.10K,VIECTBEIIIIHE 011YX0J111 B 1i:1111111HE:
21
ato,aa.nocb neKoTopoe cHimemie Temna pocTa onyxwieil ii 3ameTHoe
nue cpoKa NUI311H paKoBbix mbnueil. flo1i BA1i511111eM Bupyca B onyxwieBbix
x.rteixax lia6Jima.nocb ycimettne sumeintil nindlo3a, ciimemie flJla MIITO-
30B, yBe.ninemieneKpoTtriecKiix yqacTKoB. Floure nepecalum, onyxwm 3apa-
)Keinibte Bnpycom, He pownt B 5 113 10 c.nyttaeB, T. e. wipyc 3aNICT110 BJ11151J1 Ha
)1013Hecnoco6HocTb onyxwieBoil maim capKombt 180. Lilaprizec, ,Elawic it
l(on (Sharpless, Davies, Cox, 1950) Hawaii, tITO Bilpycbi ,pyccicoro Fr3anaA-
110-1111.11bCKOTO simetkazirra cnocoOlibt iBbI3bIaaTb perpeccmo re TOJIbK0 cap-
!COMM 180; HO II 3.tioKattecTBemibix Jitimtpon,a,Hbtx onyxwieil y Kyp, He riputin-
HRH noczep,Hum mixaKoro BH,tuimoro Bpe,Ra. ,Tipyrne aaTopm (Southam,
Bronstein, Webber, 1951) ycTailoBwm, t1TO 3anmi10-miabctoifi Bnpyc onoco-
6eH ,apemeHHo 110/1,aB.TIFITb pa3BHTHe zeilicerntm y ,rnbuneff, XOTH 11 He yX/1111THeT
cpoica mx )1(113H11. MpoBeAmmbte pa6oTbt no dICTB1110 BlipycoB Ha nepewi-
Baiouwecti onyxwm He mormi He HaTOJIK1iyTb Ha 11011bITKII ilICTI0J1b30BaTb B11-
pycbt npir .nmieHmi 3J10KatIeCTBeHHb1X HoBoo6pa3oBaHHil y irezoBeKa. Bierman
it ero coTpy,amiKu (1950) .Ha6.nio,Ra.nn nommarreabHoe ,ReficTBHe Bupyca. HO-
maubero arpaHy.nouirro3a Ha TemeHtte .neilKemnu y atoaell. Higgins H Pack
(1951), npm3HB :13 ne.trilx JIIHI15I BaKuntly 6eineHma 30 60J1bHbINI me.rtatio-
crnorim lia6,moRaTb B 6 carrasix ymeHbuimme H ynaomemie Repma.rib-
11b1X ?meTacTa3on, B TO npemB KaK, no NuteHmo aBTopoB, pa3BHTHe H0BbIX me-
TacTa3oB 3a):Lepm1Ba.nocb. Southam H Moor (1952) npoBum Ha6mwteinitt
na,tt 6ozbunim ItHCTIONI 'paKonbix 60J1131113IX, KOTOIMANI B u.e.rmx Tepanun 6b1J111
'Heilpurpormbie B OXIONT utyliae He 6brao AocTurHyro
AJIIITeJ115110r0 344eICTa, HO B rpynne 113 34 60J1b1113IX, flOJItillB1HhIX ripm3HBxy
Bupyca ertineTcKoro aiwakamiTa, Ha6,niwi.a.rnicb Bpemem-tme perpeccini ony-
xaneii. Toolan H Moor (1952) CLIIITaIOT, tITO erimeTcKat Btrpyc 101 oxa3bmaeT
pa3pywaiomee ReftcTBrie -Ha 3n1-f,eprnowniyio Kapumtomy tiezioBeica. Haxoneu,,
Southam u Moor (1954) npfIBITJUI nwrparnycKyaapHo 13 u,e.orx Teparnut Bnpyc
3aria,tworo Him 84 60,TIblibINI C pa3J1119Hb1M11 4)OpNIBNIII 3J10KatleCTBe1111b1X
HoBoo6pa3oBatitifi. flpii 3TOM Ha6mo,amocb wiepyioutee:
11C113BeCTIIa; NIO)KHO BbICKa3aTb TOJIbK0 npeAnwiwKet-me 0 TOM, tITO KJIeTKII
nopamembix onyxwieil )10JOKI1bI cop,epxam Beinemo, ?Heo6xo,aitmoe Bnpycy
pa3mitooKaniti, it tITO pa3pyweHne paKoBbix KTIeTOK iimeeT MeCTO Torita,
Kora Bilpyc ?HaititHaeT 60p0TbCH>> C KrieTKamti 3a 3TO runoTeTutiecKoe Bet1te-
CT130. 11OCKOJIbKy 1i,aMHbTi Bupyc 51B.T1HeTCH Heftpurpormbim, mommo widiaaTb,
t1TO noz,o6Hoe Bentemo itOJIHMO IlaX0,IIHTbC5I TaK)Ke II B IlepBHbIX xamax.
,aa.nee Myp ycTaHoBit.iia, tITO nermepbwribie naccam Blipyca 113 OnyX0J111 B
onyxo.tib ycimitBaior ero CTIOCO6HQCTb pa3pyulaTb capKomv 180 (or 20% .1--
Ao 100% npitimmix onyxwiefi). 1-Iao6opoT, naccaxoi tiepe3 m03r Belly!' K
Hirrenciumocii) mipyclioro TymopoTporm3m Bilpyca
3a6aneBaillisi
+ y 36 OTCyTCTByCT y 6
0 y 21 110J10>KIITeJlbilbtfi y 36
?y 12 it361ipaTeoblibiii y 141
TO.TIbK0 B Oily:W.111
FlpiiBeaetittbte ,laillibie He .1103BWIRIOT roBopaTb
Kaituepo.1113
onyTcrnyeT B56 CJIrlaBX
?II 10 czytianx
nwio1lTe.r1bIIbIii B 6 crly-
tiastx
mi 0 npo,a.tiemiii
TIOCTCTIe11H011 yTpaTe BIlpyCONI ero OHKOJIIITIFIeCKOft aKTITBHOCTII. 11p11
lin 0 cytnecTBeintbix 11.1111 ,TIAIITeabHbIX 113NIeHeHHHX. B Tetienun 3a6ozeBalni51.
Te.11b11b1X naccawax (80-90 nacca)Kefi) trepe3 ocTeoreHHbie capicombi Rupp-
C apyroil CT0p0Hb1, BlipT (Birth, 1955) B CBOer1 063opitofi cTaTbe TOBOplIT o6
HatutHaz BbI3bI3aTb TIO.T1Hb111 J111311C 011yX0.T111, Tor.aa KK 6e3 npeaBapirreab-
onbrre npIIBIIBKH Bnpyca 128 60JIblibINI C pa3JUUMBIN111 3J10KatIeCTBeHHbINIH HO-
IlbIX naccaweil BHC 110t1TH He ,rteilcmoBaa Ha Hee. Pa6oTbi Mvp nOJiVtrHaui
1.3oo6pa3onamoimn, npitt-tem B OTAe.T1bHbIX cxyganx 1-Ia6J-nwla.rmcb 3amembie
noRTBermaTHHe IT pa3BHTIle B ptme HccaextoBamlii. Koriposmil II FfopTolt
yap-num-um. BlipycamH?n!imeT Amee BirpT?naxoAwrcti ewe B
(Koprowslu and Norton, 1950) noKa3a.tni, tiro 1-1006HbINI )Ke ,aeficnitem 06-
Tpyarom neplioAe TipewtwielniB nepBoHatia.tibmpix Tpy,mocrefi, HO 3Hatm-
.TialtaioT II HeKOTOpbIe apyrile HefipoTponxbie BHpycbi: Bilpyc 3Hum4murra
14,
TeJlb1-1131X ycnexoB B 3TOM Agile MO)KHO >K,r.taTb 13 6JIII)KarmIlle rorthI. ANIepH-
HTIONCKOro 3Humbaj11jra, BeHeu,y3.nbcKoro 3Ham4artirra II iftipyc
[11
KaHCKIIr1 licuie,rtoBaTeob C3611H B cBoem ,rtoma,Re, npoturramom B MOCKBe
3anaa1-joro Hima. noc.rte,u,Htix 'Bilpyca oKa3a.nHcb aKTIIBHbINIII TIO 01110-
(1956), Taime KocHy.ricst sToro Bonpoca H BbICKa3a11 .MbICJ1b, tITO BO3N10/KHO
memtio K aiimtbocapKome, OCTe0FeHHbINI capoa ii 3rarre.tmome BO 771.
noimA0611Tcsi B ueiixTepannu paKa nowie,goBaTeabHo npiimmaTb He 0/111H,
Buckley, Buckley n Snipes (1951), Ha6.Tnuasi AeficTillie Bupyca ammPazitTa
a Aim H 6wiee pamilLnibtx wipyca. YIIIITbIBaH BC e cica3aHnoe, ovum 6b1
Ceft-JIyit Ha capKomy 180, yeTaHOBIIJIII, t1TO 3TOT 13Hpyc .crioco6ex TiponilKaTb
IlpaBHJIbHbIrn paccmaTpHBaTb 3TOT pa3itez 6noTepannu paxa B KaKoil-AH6o
z
B onyxcobli pa3mHwKaTbc1 B Heft, HO TOJIbK0 B TegeHtie orpampreHHoro nepit-
wta Bpememi. FlpH BBmkeHtni Bupyca NIbTILTaM C OnyX0JIHNIH Ba6-
Mepe 3aK0HtIeHlibIM. MwrepecHefiunie pa6oTbi 0 B,111151111111 BilpycoB Ha onyxo-
)KITBOTHbIX 11 tie.noBeKa TOJIbK0 Hatiimaionsi.
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 ? CIA-RDP81-01043R001900080003-6
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_a
;LEI1CTIHIE 1'A3.111,11IIIX MII1i1301111bIN 111'02LS'Ic1 013 tIPi
3.110KA4ECTBEI111131E OliYX0:ir-rt atv.A. Ltrtrft.11.1?r.
8. cl)HJIbTPATb1 KYJIbTYP rPHBOB 14 11PO,LIYKTbl
,TIPOAOKEBbIX KJIETOK
Cpexi pa6or 3T01-0 pa3A,e.ria BHIIMaHlIe npinvieKaior pa6orbi,
nocBrnneli-
iiie Aspergillus fumigatus. Kidd (1947) noKa3a.ri, 11TO Kycotnm paKoHoii
.onyxo.rm Bpayn-fhipc xparniKa CTal-10BH1C51 Hexa131-Iecnoco6iibimil Tiocze no-
rpy.,KeHnsi IIX B Hew1Huum-11A clni.TibTpaT Ky.libryp. B onbrrax Meyer
(1947-48) Kycotnui Tpaiicn.naHrimyemoll Mb111111H0r1 onyxo.nu o6pa6arbma-
JIIICb norpyweanem B CIHIJIbTpaTbI,Kyabryphi Aspergillus flavus. OnabrpaT
AeriCTBOBEI.TI, noltamrinn poor paKOBbIX KJIeTOK, TO AericrBile 11P0SIBJ151J10Cb Ha
341 ACIlb KyJIbTIIBIIPOBall1151 C maKcirmymom dia 7-il ,11,eHb II 3aTem CTIOHTa11110
iictie3a.no no ncretienim 8 AHefi. DTO awri16.nacromHoe AeficT3He riptimicbmaer-
CH IVIHOTOKCItily, KOTOpblrliiaxomircsi Tame B cillinurparax Ky.mbryp Gliocladi-
11111 11, no AallHbINI Kidd (1947), tnoco6eH 110a13A51Tb pa3BIITIIe mbrunmoil
.flinukocapKombI cap,a,Hepa.
M3yt4e1111e BJ11151H1151 npQr1yKro3 o6meria pa3,111111HbIX 11ITaMMOB Ky.ribryp
Penicillium, Aspergillus, Actinomycetes, Basidiomycetes Ha ,pa33HTHe Kap-
Lumom, capKom 11 mezaHom y MbiWeii 6buio npeamerom Hcc.riefisoBaiiiisi Stock,
Sigiura, Rhoads (1948). O1a3a.nocb, 4T0 ClnIJIbTpaTbI Ky.nbryp Penicillium
notatum in vitro ire TOJIbK0 ,a,erICTByIOT Ha paKoBbie TKal-111, HO 11 OKa3b113a1OT
HB110e no,3,ammomee Reficrmie Ha pocr nepe3H3aioumxcn capKom 180, oxia-
Ko coa6o 13.9115110T Ha CHOHTal-111131e onyxo.illi A1011041-1b1X }KCJI.e3 N1b1WerI. B ()MI-
MIC oT 6aKrepna.abHbix TiarnicaxapH,Ro3 (HanpHmep B. prodigiosurn) cim.nbr-
pant 3111X KJIbTV NC BbI3b1BalOT B onyxomix remoppara.
Reilly II Stock (1951) BbIACJI11.511 113 (piiiibrparoB Kyabryp Aspergillus
fumigatus ckawrop riporenHosofi npnpop,bi, oica3bmaiow,Hil 3amerHoe noika3-
,Ti11toutee imiicrime Ha capKomy (180) Nibiweii, comaKo 3T0 Bentecno 6buio
Hecbma TOKC111-1HbINI. ,aa.111311er11.11aH otmcrica awrmmoro Hatia.na He ila.ria
CK0,1131(0-11I16y,11,b 3amemoro CIIIDKCHIIR ero TOKCIPIHOCTII ,!1,JIR Mbnuefi. n0.1b-
3)751Cb 3.1eKrpockope3om, momo 6buio ycraHomirb, 11TO DTO neaLemo OTHO-
CIITC.51 K rpynne 6eJIKOB C III-ITeIICHBHO BbIpa/KeHHbINIII OCH01311b1MII C1303ICTBa-
MI1 (Peterman, Hamilton and Reilly, 1952). Fosopn 05 Aspergillus fumi-
gatus, i1e.111,351 He BCII0MHIlTb &Lime pammx 011bITOB (Mc. Leod, Ravenel,
1938) ,rietieHnsi c 110N101H,1310 3KCTNIKTOB Aspergillus niger H Saccharamyces
cerevisiae: B psme caytme3 Amex() 3awernuero pawa y sno,Reil ,Ha6z1o,u;a.riocb
ymetibweime onyxoreii. KycotiKir onyxarieil, B3FITb10 flpi1 6nonciiii, AaHa.rui
xapruily Aereliepanini iiHeKpo3a onyxo.neBoti TKal-111. Ho 13 3T011 pa6ore neT
Tio;tpo6Horo onlicamm maiimmecimx H .ria6oparopHbix ira 6nojieii ii ii. Tax)Ne
orcyrmyer 01111CaHlle C1100060B nptiroronzeHim npumeHeymbIX
DKCIpaKTOB.
TpyitHOCTI1 peuiemm 110,11-151TbIX 3,ReCb 'BOI1p000B (He TOJIbICO B ornome-
111111 [m021)71(1'03 n.TieceHeil, HO 11 BCCx aliT116J1aCTOMHbIX aHT116HOTHKOB) o6yc-
J10B.rIellbI Ile.1131M 1/51,LI,ONI 0,111-la 113 MIX mo)Ker 6131Tb noKa3aHa F121 Tim"-
mepe, B3SITONI 113 pa6orm Reilly (1953): 113 cemii BblAe.11eHHbIX IllTaMMOH
Aspergillus fumigatus min coAepwa,Tni B cim.abrpax Kyabryp
B OTHOILle1111-11 pawa BeutecTim, a ,r_ma mamma 61311111 HOJIHOCTMO 111-1aNTI1B-
11b1MII. ,Thpyrasi Tipp-ma Kpoercsi B TOM, 7-ITO xapawrep flhliaHi-in H yCJI0BII5I
Kyabrimiipommig Hmeior ogeHb 6ambume BJIHHHH Ha mera6o.rni3m mimpo6o3
ii na 1IX CHOCO6HOCTI3 imma6arbmarb crieHmlilitiecKne BeulecT3a. 3T0 cynte-
CIBeHHOe 06CTORTeJlbCTHO .3,e.naer 1101-1 5ITHbINI nporimopeinm, K?gropbie TIOCTO-
211110 Bcrpetiaiorcsi npli onefixe H riposepxe ,pe3,7.11braTOB Tex HJIII 141-11DIX pa6or
11 06JIaCTH alITII6J1aCTOMHbIX aHTII6HOTIIKOB.
* *
H3 Apyrnx pa6or 3T0t0 pa3,use.na no 6norepamm 3KcnepiimeHra.m)Hbix
onyxo.neil, 6bITb moxcer, czellyer npimecm ncc.neorAoHarnin Amemica (Angelis,
1949), Korophal ripeJVIO)KILTI MR npiotenemm B OHKOJI0r111-1eCKOf1 NJIIIHIIKe
npenapar ?Mnuerim?, immyukeinibtil B TipoAmy .rietieHim 3.noKagecneH-
1ibIX onyxo.neil tiezoBeica, a Tame 13,.1151 npeAonepaimoHHoro rum nocaeonepa-
unomloro Aetiemisr, J1.11H JIneH1151 B icom6iniawm c .ffygeBoil Teparmeil H T. ,EL.
flpenapar qMinteTHH? nozytieu H3 cilliabrpara 3pezbix ,Ky.abryp rpH6Ka
Streptothrix fells.
Huo yKa3arb, HTO MIIHIIMaJIbHaH .nera.nbHan Ao3a ?Mnu,erima? otiellb
6.1m3Ka x Ao3e TepanewrimecKoil. Taw ii.rm image, HO Aaabilecauero pa3B1ITHS1
rra annepumewrazbHan pa6ora, He roBopsi y)Ke o w.ninumemix na6moiLemi-
no-BHAHm0my, He Tionytnum.
* *
11011bITKII 11C110.11b30BaTb pa3JImmbie MUM Apo)meil np0,71yKrbI )K113-
HeReaTe.11bH0CTI1 AJ151 .nellemm 3110KatleCTBeHIII3IX 011yX0.71erl 11p0BOASITCH y)Ke
Ammo (cm. H. H. Flerpo3, 1947). K OTHOCIITeJlbH0 AaBH11-M pa6oram B 3TOM
nanpaB.wHim ornocwrcsi Hcc.rieitoBaime H. fl. HeBopo)KKHHa (1935), noKa-
3amnero, 11TO rycrue cycneil3HH Apomoweil Saccharamyces cerevisiae N XII
(6ep.rumcKasi paca), 'imedtkeimbie HenocpeAcT3eImo B ax(eHoicapuimomy apan-
xa y 131313b1BaIOT B u,e,gom p51,5,e c.nytme3 'perpeocino ,osnyxo.neci.
3a nocamee Hpemsi B pa3.rumbix ipa6oTax (Hanpumep, Protti, 1948-
1950) yKa3bIBB.TIOCb Ha KaHgepb.nwrimecKoe AeficT3He ?Kinmix 4)epmeHroB
pairmtnibix caxapomimeTo3. Castelli ii Gaggini (1949) iHa6.inoRann, 11TO ,nrai
KoHraKre in vitro IS.TIeTOK MbIIIIHHOr1 afi,CHOKapIIIIHOMbI C p5MOM BILL1,013
6.nacromH11.eros paKonte KJIeTKII nop,Bepraiorcsi J111311Cy, oxBarbmaioth.emy
311aturre.Timylo iix HaCTb. 143 if,p0)10Kerl aBTOpbI 00060 ,BbLae.1111.1III Oidium al-
bicans. fIpn HHTpanepwroHeaabHom .BBUCH1111 -1-1a3BaHHbIX ApOil0KerI Mb1111aM
C meHoKapumnomamii paaHHTHe iix ocraHamimmocb, H B HeNOTOpbIX caytia-
51X 1303HHICaJ1 HeKpo3 onyxcoeil. Kam-arum 11 raiummil .ctniTaior: a) 0. albi-
cans o6.riaAaer JiHrimecimm Aeticrimem no OTH011ieHHIO Ic KJ1eTKaNI Mb111.111H0r1
aAeHoicapnimombi, 6) 9TH Apomacti He OKa3bIBEH0T HHKaKoro B.I111511-111H Ha Hop-
ma.nbHme menu' 13) JiHrHtiecwasi aISTIIBHOCTb ycitramaercsi HRH naccmax Ha
)1(11BOTIIbIX: BBeueHHbie pawonim mbiumm 0. albicans CTIOCO6HbI no,rtaH-
JI5ITb MHT03bI onyxoneimix .K.TleTOK.
9. ,REACTBVIE AHTI4B140THKOB, BbIllYiii,EHHbIX (13APINIALLEBT14-
11ECK014 IIPOMbILILTIEHHOCTWO, HA 3J10KAIIECTBEHHIDIE
011YX0JI14
LIIHpowoe npumeHeHHe nemm,H.runina B repannii He morzo He BbI3BaTb CO-
OTBeTCTBylOLLUIX pa6or B 3KcriepHmeirraabHofi OHKoJiOrhiii, Cornman (1944)
Ha6.1no,aa.n, tiro HeotimHemiblil neHnuma.rmii o6.fla,Raer SICHO BbipmeHHbim
zera.ribi-thim ,Reficrimem Ha 3.noKageme1-r-ibie KJIeTK1-1 MbIllIerl, Haxop..51-
umecsi B yCJI0B115IX Kyabryp Brie oprami3ma, 11 -He 3aTparimaeT KJIeTOIC Hop-
maiibubix. Beard (1944) yClsallOBIIJI, 11TO 11e041311_teHlibIrt fieHHHILTIJIHI-1 /Lefler-
ByeT He TOJIbK0 Ha 3.,Tioxa4ememibie KjIeTKI4 BH e opraHH3ma, HO H BbI3bIBaeT
npilmepHo B 20% perpeccmo pice pa3BIMIIIHXCH onyxozeci.
Dobrowolskaia-Zawadskaia (1946) Tame noarBepAima Ha6,1nozkemie c
11eH1111,14J1J1111-10M B 011bITaX C onyxcomm mbnueil H OTNIeTHJIa.11051BJICHIle 111-1TeH-
CHBH011 rnnepemHH B 3J10KalleCTBeHHbIX TKallaX. STOT 3cinpewr 6bui BpemeH-
lIbIM, in ec.rni .Tietiemie awrn6norimom npopp.ma.nocb, TO onyxaTill cHoBa
;'?'r
;
It
I
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 ? CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
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1310
24
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nPOJIYHTOB HA
Hatuniami pacTH. Y oinofl 6OJIbHOfi c AecciimiiimpoBaimoil wienoKapuiniomoil
rpyAiroil KCJIC3bI,E[o6poBanbcKaH-3aBaAcKas1 Ha6.1noAaaa, KaK ,no,a BJIHaIIII-
CM npolicxoAnnii Te )ice S1B./el-11M tITO 11 B annepiimeirre Ha
mbhuax. BO3M0311110, t1TO aKTIIBIIOCTb Heoimiu,einioro rjeiuiwljlJuula'B OTH011.1e-
H1111 HeKoTopmx onyxo.fieil cim3aim c Tem, KK noKa3a.nii Burk, Hesselbach,
Fischer (1947), t1TO aMOpc1HblH J1CHIILLILTIJHIH BbI3bIBaeT 3amenioe nwiamemie
abixamm paKoBoli ii HopmanbHoil Timm mbnueii, B TO BpemH KaK
;fan 3(1)eKT B 10 pa3 meilbwint OAHaKo it eotllluJ.e}IIrbni
r10111t11,11.11.711111 AeficnyeT Aa.leKo He Ha Bee Bub' nepeEmBammixcH onyxo.neil:
Bennison (1949) lie mix. 3aMeTIITb 'KaKoro-.Tni60 JI,e11CTB1151 Heotiingemioro
TIC111111,1ITIJIIIHa Ha onyxwm mbaueil, BbI3BalIFIbIe MOJI01111bINI 11/aKTOpON1. ECM
01111111eIlHbI11 TIeH1111,III1.111111 He awrimeii B OTHOWeHIIII onyxwieil, TO Bonpoc o
TOM, Kaithe conyrcnyiouve Beniecna o6.fmAzuoT airrii6,nacTommil aKTHB-
HOCTb10. OCTaeTC51 OTKpbITbIM. B noczeumee Bpemsf pHA aHTII6110TIIKOB 6bui
iipiimelieH B 3KcilepiimeHTa.nbHoil 0111(011011III.
AllT116110TIIK
0613CKT
PC3y.lbTaT OEI biTa
ALITC
KnaBaunit
AypeoNtitatin
AKTI111011111111111 ii
IIIITPIIII
Teppaminuni,
aypemuunit,
IICOM II LU ill
AKTII ii OM hUh H,
aKTI13,111I.
Aim AI, unniciaini S
Teppaminuni
C
A3ZICCp1111
Capkoma 180
Ka ptuntom a EPIC
Capkoma 180
Capkoma Poyca B
icy.m.rypax BBC op-
rainiama
Capkoma 180
Kaputinombl kpbtc
Ca pkom a 180
Upu norppkeinin B
all-
TH6IIOTIIK KYCOtIKOB 011Y-
X0,111I capkomnbte KJIeTKII
CTBIIOBSITCSI 1101iII311CC110-
C0611bINIII
Mimic BO3bi crtimynii-
pyloT, 6onhunie no,aaBna-
10T pOCT icapuititoNt
Cna6oe no.aannmotuee
BefiCTBIIC ha pocT ony-
xonii
3aaepkka pocTa
Cna6aa Baaernkka
pocra onyxoneci
Cna6an aaaepaata
pocra onyxonefi
3aaepkiiBacT pocT
onyxonefi
Stock,
Sugiura ?
ithoa ds,
1949
Sokolo ff ,
Eddy, 1951
Stock, 1950
Chinn, 1952
Reylly,
Stock,
Buckle) ,
Clarke. 1953
Hackmann,
1952
Stock,
Reilly,
Buckley,
Clarke.
Rhoads,
1954
HCC.rle,a0BaJ111Cb Taiome ilm.ribTpaThi 'KyabTyp 1068 pa3JIHt1HbIX 11011BellHbIX
mimpoopraiut3moB. 1,13 5059 11)11JIbTpaTOB 878 (82%) Amu
pe3y,ribTaT. c.fia6oe Topmo3Hafee AeficTime 6bizo OTMetleHO "1,..1151 174 finuibTpa-
TOB (16,2%), ii ,HaKoHeu, )1;151 16 (1,5%) MO)KHO 61)1.110 OTMeTHTb ymepernibici
Topmo3siumil 34)(1)eicT, T. e. CpeJHufi AliameTp .rietieHHoci onyxwm COCTaBJ1 51JI
114-1/2 AnameTpa onyxwni (CapKoma 180) B 'xowrparre (Reilly, Stock,
1954-1955) .
3:1011AtIECTBEIIIIIIE onyxwin 1i:1111111111:
25
Aypealtutfutt 6m.rt npnmenen Bateman, Klopp, Barbario (1952) 'B Katiecne Bcnomoranablioro cpaKTopa npii Heonepa6H.nmibix paKOB c no-
mow,bio 'peirrrenoBbix .nytieci; aBTOphl ynep?KAaioT, tiTo iiM wiariocb B
caytiasix cAeHaTb onyxwiii AocTyruibimii A.J151 xllpyprivecKoro BmemaTe.ribcna.
BbIJI ca.e.riair 011bIT npiimerieinm y 17 60JIblIbIX miTpaapTeptia.riblioro BBeAeH1151
npenapaTa roptuitifioro ra3a 11 aypeoNiiiiiima; Bateman ii ero COTpy,L1IIIIKI1
(1953) 011HCbIBaIOT, tITO 4 60JIblIbIX 6blJIli nepeBe,Reirbi 113 Heonepa6ii.riblioro
B onepa6H.nbtioe cocTomme. HaKoHeu,, Bernard 11 Kessler (1953) Ha6zioAa-
.111I 110J101KIITe.IlblibIe Kaimutiecime cABlirit y pHAa paKOBbIX 60.11bHbIX, y KOTO-
pbtx. npoBoAmocb aetiemie aypeominumom (a Tame Teppamiumnom) B come-
Tanitii c AKTF.
PHA Hcc.TreAoBaTe.iidi o6paTim .mitimamie Ha aHTH6JiacTomHbie cBoil-
cna nypcmtutititta: 6-Aii1erma1inio-9- (3'nap ameToKcH-L4eini.naz amnia Mil-
llo-3'-3oKoH-D-pii6031IJI)nypim. Troy H ero cowymnum (1953-54),
mytiim Aeflcmile nypominuma B OTHOUI1Ii1ht =MTH 'pa3J11111HbIX
noica3ann ero 3ameTHoeAeficTime Ha ralio6RacTomy ti
aAetioKapuimomy M0.110t1HbIX ?Keze3 y mbnueil 031-1. FlpoTHBoonyxwieBaH aK-
THBHOCTb 3T01'o aHT116110Tmca CB513atra C aMHHOHyK.T1e0314,a,H0r1 tlaCTb10 ero
MOJIeKy.11bI (Benett, Haliday H Ap., 1954-1955). AMIIHOKIICJIOTHbIe ammorn
nypommunia 6bIJIH 11C11bITaHbI Ha meHoKapimHome MOJI011HbIX. ?Keze3 MbILlleil
C3H. 143 21 Aepiman nyponnu,HHa 5 coeAHHemici Aa.rui yrHeTeHHe onyxo.nn
Ha 50%, 6 couunidmil?Ha 25-80%, OCTaJIbHbIe 6bIJIII 1.1e344eKTIIBH13I. Ha
aKTIIBIIOCTb AepimaToB onnmecKaii KoHilmrypamisi aMIIHOKIICJIOTbI, a
Tame 3amecniTeab amimorpyrinbr, nopHAoK aN1HHOKHCJIOTbI H nplipoAa ca-
iofl no Ha6Aiwr,emmm Wright, Dolgopol H 14X conyAmmoB
(1955) ,11?1111TeJIbH0e npumeHeinie 3T0t0 awrii6H0nma y .Kpbic 13bI3131BaeT non-
pio Beca Tiopmeime net-mail H notfeK. Flypominum nplimeHH.ncH y 51 6wib-
Horo c Heonepa6mbHbimii 011yX0JIHMH nonocm pTa, ningeBoAa, *e.nyAKa,
Kinuetimuca, .nerimx ii rpy,a,Hoil mce,fie3bi. Y 15 6wiblibix Ha6.1noAanocb Bpe-
meHHoe ymeHbuiemie onyxwell, npmem ymeHbweHtie onyxoneil He conpo-
BONKeHHe, IITO IICII0J1b30BaIlHe 11.1TaMMOB Mor.nb 1-10B.1111RTb Ha pe3y.lb-
ttt
Declassified in Part-Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
?
4 w.
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
- ? ??????
32
PA3.111P1111,1X IIPOILYKTOB IIA
Tani. BBILay 3TOTO npeacTaBihnoch )11CJIaTeJII3H131N1113y111rb: o6.nalia1oT JUI
panbie IIITaNIN1b1 Illimorpanailym pa3J11111HbINIII CBOIICTBaMII>>.
B pe3yobTaTe TulaTe.nblibix 3Kcnepiimewron BbiUleFIa3BahIHbIe aBrophi.or-
Betialor. Ha3TOT.Bonwe n0.10)KIITeJlh140* luz_viv-PH
co.ladn.wr pa3i-ibl.\111 CBOIICTBaM11. IICCK0.11bK0 no31LHee Xaymica,
BajlbNIKBIICT H BpoyH (1950) TaK)Ke .3ansimieb 13011p000NI 0 pa3JIIIIIIISIX
IllTaMNIOB W1130TplInanym. Omnanocb, tiTO Ky.ribTypbi 7 .paaantmbix 111TaM1OB,
13bI,a,ej1C1111b1X B pamoe Bpemn B pa311bIX reorpantieciaix o6.nacT5ix, 311atIliTeJ1b-
110 OT.111t1a1OTC5T Apyr or Apyra no iix peaKwin ii a ecTememibie arraionnin-
libI lrOpMaJlbuoit tie.noBetiecKoti Cb1B0pOTKII. A 3T0 oatiatmeT, tITO paalibie arram-
MbI niimorpimallym pallifitilibI no CBOIINI 6e.TIK0B0-yrJ1e130,11,11b1N1 KommeKcam.
Y Hac Bonpoc 0 urrammax mimoTpiinailym 6bia iice.nefi,oBaH .n. B. JIeBHH-
COHOM, 113Y4111111111M ,Twa inTamma - 22 ii 28. ,11.nsi 3TIIX 111TaNIM0B
xapawreplia nx en0co6n0crb Bbl3b13aTb xpoluittecKiiii npouecc (aapmemibie
MI3111111 )1(1113y1 2-3 mecinta), Ii mulieKunn TetieT c peMIicc11ni11 npii ma.nom
tinc.ne TplinaHocom B KpoBii. JI.aIlHbIe, no.nytieluibie JI. B. JleStinconom,
no-
Ka3b!BaIoT, 'ITO 111TaNIMb1 22 II 28 painntratmen mexcity co6oti B 01110111e11HH
iiirru?itiopiroroAeficTimsi Ha capKomy 180, HecmoTpn Ha 3T0 01111 06yCJI0B-
J111BalOT y mbimeri, npit6,nimirreabHo o,a,HHaKoBoe Tetieline II1Tamm
22 6e3ye.nowio o6.na.aaeT aHT116.11aCTONIIIbINI zeuicTBIIeM, B TO Bpemn KK y
urramma 28 Taicoe CBOfiCTBO ortyremyeT. Han6o.nee noApo6no aHammpoBa.ri
Bonpoc 0 TpyiniocTrix, C 1131'OTOBJ1eHIIeNI uninTplinamioro nperia-
paTa W. Malisoff (1947).
B csoem AoK.na,Re lia IV inrrepHautioHaabHom paKoBom Koarpecce Marin ?
COB 113.710>K1D1110J10)1(11TejIbHbIe.pe3yAbTant .netiernin 3Kcnepiimeirranwibix oIly-
xoJlefi nON1014bIO ?3KcTpawra 113 unmoTpunaitym, KOTOpbIII ,iieHerayeT paa-
pymaionte na HexoTopue 3.110KatleCTBeHHbre 011)7X0J111>>. Ma.inicoB B aamotie-
wie yKammaeT: . Mamicos roBopirr: ?Hecmonsi Ha crapa.min upiiroTowin unmoTplinaii-
HNC npenapami O11nHaKoBofi C11.11bI, Haii6o.nbuiee 3arnpylieii1ie B 3TOM e.rie
ripeAcTaBana TOt1HbIti CtieT TplinaHocom. MoryT 613IT13 TaK>Ke cKpbrrbie yx.no-
Heinni B merofunce TIOCeBHbIX ic}r.nbTyp, He6o.nbmire 'BapHaunii B .pocTe ii ypo-
Ky.nwryp, B xiimntiecKoil OtIIICTKe 11 B yczowinx .1111311C1, KoTopme onpe-
.aeasnoT awrinimocTb npenapaToB?.
1-10,aB0,1151 IITOPH CBOHNI onbrram 110 JIe4eI11110 3Kcriepiime.irraambIX
onyxo-
Ma.rincos yrBepKoriaer; ?Ilo-BH,rinmomy nocpeiierBom aKT111311b1X riperia-
paToB 10 ihnii 6o.nee exceaHeBm:Ax HfrbeKunti moryT Ran, 100% perpecemo
onyxcuiefi 6e3 13pe.ria ,opraHoB... Kor,ria perpeccHn ornyxwm
npolicxoairr TIOA BJIIISIHTIeN1 npenapaTa. TO 3clxlieKT HacTynaeT 6bicrpo H B
ne-
nocpeAcTBeiiiion CB51311 C 0611111f1 BbII30)1, MaJnicoBa: ?Ham
9Kcneplimeirrbi noKanmaioT, tITO 3H,a0TOKCIIH uni3oTpunaHym limeeT 113611pa-
TeJ1bH0e Jiiimpyiouiee ReficTrine Ha 3.noicatiecTBeHHbie onyxcian mbnueil, .a
liMeHHO cnoirraHHylo HapunHomy Ma710411bIX )Ke.ne3 11 capKomy 180. DHAQT0K-
CHB unmorpurially.m He TOKCHtleH ,L1J151 HOpMaJIbHbIX TKalierI Fl B Teparieuntie-
CKIIX ye-JIM:3111X H Iipii KoHuewrpaumn B 4 .pan HaAo yxa-
3aTb, tITO amepriKaHcKne ncezeaoBaTii Spain, Malamut, Warschau (1948),
npoBeimB Hawn pa6oTbi, riciamirreautibici pevabTaT B zetieHHH
?????????,.....
3.110KAHECTBEIIIIblE OTIYX0:111 B 3KCTIEWIINIEIITE II H31111111i1:: 33
CHOIITaHHbIX paKOBbIX onyxciaell mbiweil, HO TOJIbK0 Ha onyxomix paamepom
meribme 1 CM. 9TH airropbi miwyT: ?Hamii 6buia yeTaHormena TaKag CTenelib
ttniina maw; a iv; !iv'? anti storm; y ra nti pariah, Rfi.er
pe3y.rIbTaT 6bi.n no.nytieri TOJIbK0 13 /950 r. eprangyStivirMil-
ytiembnin Coudert .B...14:1U.1101IBAbHOM 1111CTIITyy 1:314W-Ibl iaU111Lb'
CBoe coo6w,eHlie, pe3y.ribTaT rpexAernefip-ls--3?KIOTC11 HatuinaioT
Talc ?B Tetienne 50 !ler licc.nefisoBaTe.nii Bcex eTpaii inytta-
.ruiAeilmite 13e111eCTB, cnoco6maix 13bI3BaTb, ycKopirrb 11.111 pac-
ripocTpaHnTb o6pa3oBainie 3.110Ka4eCTBeHHbIX onyx.ckneil .1a6oparoplibix .>K11-
130TliblX. Ha HOBON1 nyTH B 31SCHepliNlefITaJIbH0i1 KmunitiecKoil o6.naern - 6no-
Tepaniiii 3J10KatleCTBeltliblX OnyX0J1eri... 3atIIIHaTeJ151M11 imytianiu 6bmii MO-
CKOBCKIIe nec.neaoBirreati. Euie B 1932 r. OHII yrBepHmaJui, trro unnoTplina-
Hym HAiipare.nbilo napaairrtipyeT ii pa3pywaeT mem onyxanefi. IcrnoeBa ii
POCK1111 113BJ1e11a.11H H3 un130Tpunanym 3KCTpaKT, 06J1a/I,a10111,1111 TaKiimn >ice
eBoticrBamit?. 14 Aa.nee )1(Kyrelilniimyr: ?B pa3HbIX eTpanax 6bian
TIpallpIiHaTb1 KOHTp0.11bHbIe OTIbITbI: BO (1) paHuHn 01111 HatIllHalOTCSI C Rue-
cepTawni PloAa.nti (Flapir,K, 1941 r.), KoToputl coo6ukaeT o6 onbiTax
BOJIbH0 06W,(5. 1-Ia060p0T, '13 CLL1A Mb! Haxo,tuim 3Kcnepiimeirra.nbHbie pa6o-
Tbi, 311a1111TeJ1b110 6ariee Bumble: B 1947 r. - MamicoBa, B 1948 r.-
Mo.nomyr ii Bapmay; XaymKa ii B.nep. FlepBbiri cue.na.n o6HaReNd1Baio111.ee
3aK.niotiemie, Apyrne coo6iwinii o pa3Hbix pe3y.ribTaTax, ?Amax?, He ?Tillman
TIOJIHOCTbIO ,aerICTB1151>>.
B pe3y.nbTaTa CB011X 011bITOB ky,Rep II )K1OTCH nplixo,auT K eneiviouttim
BbIBOAaNI:
1. B Tex onbrrax, rite .netieinie um3oin1namibim InpenapaTom ?HatillHa-
.110eb patio, TO eCTb MeNcily 7-m ii 10-m Allem noc.ne IlplIBI113K11 palm, OT./Wilfibl6
pe3y.ribTaTbi 6buni no.nygeHm B 60% (onyxanti Hctieaum H Bee )1(11130Tlible
ocTaBamicb NUIBbIN111). Xopoutue pe3y.ribTaTbi 6bIJIII 110.11ytIeHbI B 30%i 11
noppeacTBeHHile B 10%. ABTOpbI eturraiar, tITO JII13aT umaoTpimailym
;lam- aocroaeptotit aeficrette,it patwebte ortyxoAtt, ,RecieTwiem Tem 6o.nee
tleM B 6anee paHHeti main pa3BIITHB onyxo.rm HatiaTo .netieHHe
npenapaTom.
2. B unnorpiinaHym COOMICUTCR alC7116H0e aeuiecreo, 1136upareAtil-to
Oeficreipottwe iia 3AowattecTeet-tuyto TICattb. 141-CbeMMLI, CaeJlaHlible 6 3aopo-
able TiCaMI, tie 6bl3bl8a1OT (3 MIX Hutcalcux ,1108pe)/caetitta.
3. (rJ/U.3ar tutt3orpunanym, no-mtatimalty, aeticrayer KOK cneutuPutte-
clittei OHT116110711K, 6 cuAy oco6oti 11Y6CT6II7'eAbHOCTU 3.401CatleCT6eliftb1x Kize-
TO/C, atte 3(2611CII1IOCTII OT 11X '12POlICX031Coefill5l, 110006HO roAty, katc 9T0, no-
ettatotomy, noareepoicamor neaa6Hue KAtattylecKtte Ha6.1uoaettuR.D.
Kai( mii3orpiinaHHaR TaK ii ripoTHB9paKoBbiri airrii6H0THK,
TIOJ1ytleHHbal 113 3T1IX TpunaHocom, o6.riaaaioT unipoKiim cnewrpom )11efICT-
B1151, T e n0.110)KliTejIbH0 B./115110T Ha pa3Hoo6pa3Hbie B11)1,bI moKatiecTBeH-
HbIX onyxo.neci, KaK 310 BIIRHO 113 Hii?KenpHBoximmx 1I.aHHblx. 14HrH6I-rrop-
Hoe mit KamleparniTtitiecKoe Aerie-rime iii II30Tp imaunoii 1114eK11.1111 fisoKa3aHo
;Iasi c.ne,nyiouu,ux B111108 ortyxo.neil; 1) aueHoKapiiiiHoma -Dpanxa N11,1111e11
(r. POCKI111 n E. Sicaemn.asipcxast, 1931; F. POCICH11 11 K. PomanoBa, 1935);
2) .pa.K ximpic (F. pocimi ii K. PamaHoBa, 1935); 8) C1-1011TaIiHbIcl
paK mbiweil (H. K.nioeBa 11 F. POCKI1H, 1946); 4) capKoma 180 mbuneil
(H. KJ110eBa III A. EMI:mums', 1946; OnbITUI B. Jleimeolia 1947);
5) paK BpayH-FIlipc Kpo.niiKoB (OnbITb1 F. C. I0maineBa, 1949); 6) tiemyil-
tiaTo-K.nerotmaK KapunHoma 119 mbaueti (Malisoff, 1947); 7) capKoma 37 MbI-
Lueil (Hausclika, 1947). 8) cricirranna2 auelioimpunHoma M0.11041IbIX
mbrureii. OTHOCHTe.11bH0 CJIa6bIri 3I1B13eKT (HaUSC11ka, 1947); 9) HeKoTopme
B111:1bI 3J10KatleCTBeHHb1X orivxaneil tie.noBeKa, iia6moueHtin HU, iiHxypa6H.nb-
HUM! 60.11311bINIII (Gaillard, Brumpt, Martinez, 1950). 1/1Hrii6wropHoe Will
;
?1
fit
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
It
ta.
34
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
f
? ...CO
_
CTIIMWIATOPM a 11111111111T0PU aPoCTEa11111X 13 ACIaltIE
arOBAEMIA AaTaBlIOTIIK0B I110T030111101'0 IIP0IICX0NCIJC111151
Kmatepo.rnmpiecKoe dcrone pamatmo nparoTomemibix npenapaToB 113..
IBIBOTDallaaVM 1100Ral11;? 1.71;_cm.pyinp741Y T1:1,0C onyto-let Al7a941,:q. 7
----niur31 isfiguirtPorffiricPoiiiiioBa, I 3);9 'P a K ,E1>Ic 06-
Kpbic PocKan a K. PomalioBa, 1930); 3) capKoma 180 (r.
na a A. 13o6pinwaH, 1946); 4) Fic 63 Aibilueii (H. 1011oeBa a A. Bo6paus-
mu!, 1946); 5) pa K Bpaya-Flapc KpoduKoB (011b1Tb1.
Fl IcnioeBoli
a. M. Fimu,6ypr, 1947-1949); 6) onoriTamible onyxo.riii mo.riotnibix )1e.r1e3
\,banefi (011b1Tb1 H. IcrnoeBofi a D. M. FiiHus6ypr, 1949; 11. IcnioeBoil
C. Ma.goBanoBoii); 7) cnoaTaiiiibie KapusiiitombT MOJI011I1b1X )1CeJ1e3 Mb1-
1110ii (Malisoff, 1947); 8) capKoma 180 Nibnueli (Manson', 1947); 9) cnoii-.
marble KapHimombi mbanefi, noAamealie pocra onyxwiefi, IIMe1OLIIIIX pa3-
mep ne 6o.lee 1 or (Spain, Malaniut, Warschau, 1948): 10) capKoma
Kpbic (Couclert, Jutin, 1950). 311atIHNIOCTb 3TIIX ()aKTopoB iie N101IieT 6bITb
Ka)Kabim, KTO paouran B 06d1aCTH 3Kcnepilmel-rraAb11ofi Teparnin
paKa. EcrecTuemio, B0311111(aeT Bonpoc 0 cywecTiloBaiiiiii anT116.9acromnbix
BewecTB y ,apyriix ripe,acTaBaTe.rieii Protozoa. 1103TOMy B nolicKax 11p0T11B0-
paKoBbrx affT116110TIIKOB HaWIIMII ToBapimomit no pa6oTe 6L1J iiccae,Tismaa
PM TipeAcrawiTeJleci pamitiabtx rpynn Hapcma HpOTIICT013. ame5bt (Enta-
moeba moschkowskii); iimpy3opria (Paramaecium caudatum); remocnopn-
Aiiii (Plasmodium gallinaceum); TplinaHocombi (Tr. equiperdum, gambiensi,
lewisi, kohl ? jakimow); Jiefiumlalijjir (Leishmania tropica), pa3iibix
wTamma. Pe3yJ1bTaTbI 3Tax pa6oT 6yAyT 113.110iKe1fb1 no3ikitee, Ho roBopa o6
11pOTIICTaX, ymecnio yKa3aTb, 11TO ma.ruipailHasi BbI3Ballfla2
Plasmodium bergei, cnoco5aa ap0AJIIITb i1C11311b y diefiKemiitiecioix
Mb! well
(Nadel, Greenberg, 1953).
BOJIbWOR liaK01-1J1eHHbIrt MaTeplian no aKTimilomy AeficrBilio nporii130-
paKoBoro aHTH5noTHica 113 1111130Tpanailym KK Ha nepemmaioamecH
C1101ITaHHbIe onyxoan aa6opaToplibtx )1(113O111bIX, THE 11 ripe,usBapliTeJlbllbie
KAHHittiecidie Ha5.ruoAeHHH craBium nepea Hama 6o.nee unipoKoro
maiimitiecKoro 11C11bITaH1151 3T01-0 npertapaTa, pa3pa6my HOBbIX NIeT0/10B
Ky.TIbT111311p0BaH1151 3TOti TpanaHocombr, 110.1y11e111151 6o,nee al(THBHbIX cepaii a,
HaKoneu, ,BbISICHel-EHH mexaminia 3T0r0 npoTimpaKoBoro aHT116110TIIKa Ha
3.rioKatiecTBeimbie onyxoini HeiloBeica a .11a6OpaTOpHbIX NCHBOTHbIX. 3T0ii 3a-
,Asatie nocmatenbi noc.ne,ayloume nun'. Ho npexcike Bcero Mb!
paccmoTpeTb ABa Bonpoca, ,HeriocpeacTBeimo BbiTekarowne 113 Bcero T0.71131C0
tiro 413.no)KeHHoro ameioiwie He ma.rioe TeopermecKoe 3natiemie, a iimemio:
o neKoTophix okinix a011eKTaX npo6.riembi aHT116HOTHICOB npoTo3ofitioro
apoacxo)K,ELeHHH; 0 '1111IIHHH1111 HeKOTOpbIX awPeKtuifi Ha 3.7T0KatiecT13e1mbie
onyxwm.
Icor,ga imara 6buia?y)Ke cBeperauta, Mb! corjiir 0311a1COMIITbC51 CO craTbeil
(1)paHuy3cKoro accze,goBaTeasi KyAepa (Coudert, 1956). Ha OCHOBe Haimix
pa6oT H CO6CTBeHlibIX 3KcriepriMeHToB Ky,Rep, B coApy)KecrBe c pa,aom ?Bpatiell,
npoBeii HaGaioxieHlisi 110 .npitmeHemilo wimoTpiinafmoro npenapaTa y 60JIbliblX
C LtarieKo 3ameAwiim11 cpopmamii paKOBbIX nopmemiii. FlarimKaTeablibie Pe-
3ydibTaTbi KJIJJHJ1qec1Qf acribrramal ino3BOJIHAII 14HCTIITyTy Mepae (B J-laoHe)
BbIlIyCTIITb B 1957 r. ripenapaT 113 unnoTpanaHym ?Tp1Ina1io3a? flJlI npame-
Beam' ero B wapoKofi muimatiecKofi npaKTHKe npa .71eHem1a paKa.
st
IN ? . .
AP.
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. ow.
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:35
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II tiacTb
CTHMYXITOPb1 14 14111-14614TOPb1 11POCTE1411114X
ACIIEKTE FIPOBJIENIbl AHTHBHOTHKOB IIPOT030 14H0r0
FIPOHCX0)KAEH1451
Haulm Ha6mo,usemisi HaA aura611ropH1im ,a,eficTimem ?ripoTonaa3maTivie-
cKax K01\1110lielITOB wH3oTpanaHym Ha Kama 3J10KageCTBelllIbIX onyxo.riefi
11 iimipme no)3,o611bix, HO 3iia4arreablio enee 3(j4eicraB1ib1x BelIleCTB B
meTKax HeKoTopux Apyrax npoTo3ofmbix KpoBenapa3aToB, 'lac K
paccmoTpemno 6onee 6Ho.normecKoli inpo6aembi, eA,Ba eine 3aTpoHy-
T0ii accausoBaTeasima, 0 BewsecTBax-cTamyilirropax 11 narii6ifropax, 13b1AeJ1E-
embix npoTacTamH. 3Ta npo5aema iimeeT camoe nenocpeAcTBernioe oTiimne-
Bile K Bonpocy, KOTOpbal Hac oco6o iniTepecyeT: moryT J111 npocreilume caiy-
)1(1,1Tb IICT011HIIKONI aHT116110TIaleCICIIX BemecTB?
,aaBHo Obmo 113BeCTI10, TITO Tp1IXOU,IICTbI pfi,usa im4)y3opail, cocaTeababie
nazotadi cywropail II nceB,Lkonoxia COJIlle11H111COB BbILIeJ15110T Bewsecna, am-
Ni061111143y1OLLI,He 6bicrpo mnaBwowsax MeJ1KIIX HCHBOTHbIX. 1101IIMO 3T1IX
bbI,13,e,TISIeMbIX cneHaaabtio 31.1151 3a1.11,11TbI 11.1111 3axBaTa 111111IeBbIX
neKoTopbie cBo5o11sHo-)Kpyw1e, a Tame napa3HTH4ecicae npocrefluine Bbl-
pa6aTbiBaloT ,Bew,ecTBa,01311Tbre Ajar paanatiabix 6a.KTepail, upocreilunix, a
TaioKe TKaHeil BbICIIIIIX HCH1130T1-lb1X. BMeCTe C TM y npocreciumx 6b1.mo OTKpb1-
TO Sammie imoro xapaKT'apaY
Po6epTcoH (1921) 6bia 011,HIIM 113 nepBbix ICTO o6paTim
BIIIIMaHHe Ha TO, 11TO B 0,5,HOM H TOM mce 06beme 1111TaTeJ1bHal cpextbi ABC na-
pameu,HH pa3mHo)KwarcH 5bicTpee, Hem Qua. 3TOT (PeHomeH 6bu1 Ha3BaH am-
.TimoKaTammom. Ilapamemm, Kw( Blum, cn0co6Hbi Bbl,ReJIHTb He TOJIbli0
newecTBa Tana anne.Ti0KaTana3aTopoB, HO H BemecTBa Tana mirathiTopoB:
B JimTepaType IlMelOTCH yKa3amisi, HT? ?Alm pacbi napameimil moryT Bbme-
1151Tb BewecTBa, TOpM03HIalle 11JIH Ame ,no,RaBsonow,He pa3BHT11e napameusafi
Apyrofi pacm, KaK 3TO oma3aax HCCJIefis0BaHIISI Comie6opHa (1945).
.gB.rieFale adirie,noKaTaJm3a HmeeT 6o.nee umpoKoe pacnpocrpaHeillie Ti
He orpa?HatiaBaeTcH To.ribico napameumma. Mep6ap?Kep (Merbarger, 1943),
npoBexi Ha6.,TuoAeHme Ha,L1 CKOpOCTb10 pa3mHmeH1-IH alal)y3opHri Colpidium
striatum B tiametiKax (coRepKammix pa3JIHt1HbIe Koantiecna 2% npoTeo3o-
nenToHHoll mumicocTH), ycTailoBim, 11TO no ?mepe yBeaatleHan Hama aH4)y3o-
paf1 B tiametiKe oKopocrb 'pa3N?mo)KeHHH noBbauazacb ,B,o MKCIIMM 11 3a-
Tem cHmaaacb. Ba)KHo OTMeTIITb, 11TO BTO cHmKemie B CTapOr1 iKII4I,KOCTII
tie 6biao CBH3aHO c Hefi,ocraTKom ruiaHnr. TaKoe ycKopeinie Ii3ame,gmemie
3aBlicHT, no mBeHino Map6ap)Kepa, OT KoHugHTpamat Bemema, Bbme.rmemoro
Colpidium, crioco6Horo B 3a1311CHMOCTI1 OT KoHgewrpaustra za60.cTamyaapo-
BaTb, JI1160 110)1,2113.01Tb panimie KyJIblypbI. 3TO BeLusecTBo pa3pywaeTcH noxr,
BJUIMHrIeM HarpeBaHHH 13,0 100?C TeHemie 3 macoB.
K aHaaoratmomy BbIBO,Ity I1p11X01T M.aCT 1-13r1C (Mast, Pace, 1942) B
CB011X Ha6Juo,ReHastx HaJl, pa3mH0)KeHaem 6ecu,BeTH01l ViarezasiTbi (Chilo-
monas paramaecium). arn ::KryTaxoBbie, no-Baximomy, BbIAe.TIHIOT cTamy-.
..Tiapylowee pa3mHo)KeHae Bewecno, tlyBcTBaTeabHoe K HarpeBaHmo.
DTO BeILIRCTBO IIIMICyTCTIVeT B KyabTypaabHail B BbICOKIIX KOH-
uempausix, TO OHO nuaBaHeT ,pa3mHmeHae }KryTHKOBblX.
3*
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
1????????e..??...... t?????
IP ?
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
CTIIMYMIT0111.1
11.1.01111. ? lk? ).? .???? .3.? ? ?? ?
JR J1 Ai. ? .
314Vtli,
36
If 1111111111T01'1,1 iiroc?rEnimix B AcitEE?re.
Oco6bill laiTepec npeAcTarmsnoT Te 011bITbI, rice noKa3alio CyMeCTB013a-
Bile .B11A0B Protozoa.B autTepaType
'1
mo Colpoda saprophila, enoco6-
VKJANRIPla, Ha not-tamp? iiinpy3op
runi
Hp? 110aBATb -pa3BuTjte P.3TOTeHlibIXpii6moa, cianplimep, Fusarium J
mecemi Penicillium exp.k.tis He Nicaec 1111TepeCHO lia6moAeline, tITO
Col-
poda saprophila cnoco6Ha TaEdEe,C1111MaTb naToremioe AeileTane 6aKTe-
pull Bacillus proidae. 110-BILL1,101.0*Nt7 .1.-3T11,Aaniib1e ?Hanoi! npocpeccopa
BpoilcKoro (1942) Ha MbICJIb IICIIbITaTb aKTIIBIIOCTb notiaemiblx iimpy-
3opuli Ha otieHb oriacHom napa3nTe milornx CelIbCKOX0351iiCTBel111b1X pacTe-
111111? Verticillium dahliae Klebahn (13o36yiurresim TK lia3biaaemoro nit.Tra),
myropbth nopamtaer x.nontiaTHHK, KapTocpeab, rIoJ1coJ1I1eLII1IIK, COb II NI1101110
Apyrne Ey.abTypiibie pacTeinin.
AAA CB011X 011bITOB A. .11. BpoAcKitil B331.1 Aaa pacTemin?montiaTHHE
If TOMaT, ?11 TOT >Ke poi!. Colpoda, pa311ble BII,L1131 ROTOpOTO OCO-
()MHO 0611.11bIlb1 B notmax Toueptioft (Ha 1 ea notisbi riplixoaliTcn npu-
mepHo 30-60 TbIC1t1 oco661). Mnorotnicoemibie Ha6alo2Leitim, npon3Betten-
libIe B Tetreince 10 .ruceil KK B milkpommapHymax, TK ii 13 ma.nelibmix Koa-
6ax (10 .m.a), noma3a.nit, TO cnopbt 11)116a B I11)lICyTCTE31111 )1(11BbIX inupy3o-
pull He npopacTaioT n He o6pa3poT rpnHhIubI. TaKoll >Ke 30eKT fi,auarni
011b1Tb1 npopauumainin cnop rpii6a B 1KIIAKOCTII co.u.ep?IKe cay-
icanx, Kora ,111111))730p1111 112X0/111J111Cb B 111111,11CTI1p0BalllI0NI COCT02111111, 11X civ1c-
rJIuIurFfbIfi.9cpcpeKT TaK)Ke 11p0HBJIHJICH, HO OH 6bIJI ropamo caa6ee.
Bce .?KCIleplIMeHTbl 1103BOJIHIOT yTBep)K,EtaTb tITO 11pOTOTIJIa3Nla Colpocla
coxcep>KHT 13ellteCTBO, nouaannioucee )1(113He,ReaTeJ113110CTb enop V. dahliae, ii
3T0 BeLU,eCTBO mo>KeT ,BbIBAIISITbCSI inupy30plisimil B okpy)Kalow,yto nx cpuy.
011131T131 no cpyHriluitAnomy Aeficraillo iitupy3opml Colpoda Ha Verticil-
lium, rng owl nenocpeAcTaeimo conpliKacamicb c TecT-pacTeitilem (roaalibim
o6pa3om TOMaTONI), OKa3aJIIICb Taime tieTKo 110.710)KIITeJ1babINIII. (1)11TOTIaTO-
norimecicoe itcc.nezconainie pacTeimil, nereTirpoaaunnix 13 miTaTeabilom pa-
CTBOpe C 60.11b11JIIM icomitiecTaom Iicpy3opHil II nceaaocKzepouitil, tieTKo
noKa3a.no KK OTCyTCTBIle rpH6Ka, TaK II czeicoa 60,11e31111. TaKIIM o6pa3om,
KouraET 1111(ky3opail Colpoda c ncea,nockirepominmil Verticillium .nninaa
3111 o6pa3oaamin tix cnoco6Hociii K criopy.nmuni, trro o6ecnetnina.3o pacTe-
MIR OT inponinucoaemisi B HI1X niupeKuJni.
B TOM .>Ke none noncKou 11013131X allT116HOTIIKOB 11p0T0301IHOTO Bp0I1C-
X0)KACHI151 npeacTaaJuieT miTepec pa6oTa rapiunia (1943), IWTOpblit, na6-
J1!o,Ran Ky.1113Typb1 Oikomonas termo COBMeCT110 C pa3J1111111.131N111 6aKTep11nm11,
yeTairoalia, tiTo 3111 ?KryTIIKOBbIe CH000611131 cp.noicy.inipormTb TIS1Tb pa3.initnibix
1311/1,013 6aKTep1111.
4pyrnm npirmepom airTH6H0TntiecKlix Hemec-ra npoTo3ormoro TIpoacxm-
ACHIM moryT C-Tly)K11Tb HecuecTila, nanytiemibie MakKit (Mac Kee, 1947) 113
pima ripeAcTaBuTe.neti )1ifyTIIKOBbIX. Maicku ircc.ne,Rouaa AericTune ./1113atTOB
pmca cao6onito iKIIBy11111X )KryTHEOBbIX Astasia Klebsi, Chilomonas para-
maecium, Euglena gracilis, Tettrahymena gelei, zerico KyAbTlynnpyloicknxciran
>Emuutx cpe,Rax. ,Et.1151 nanytiemin JIH3aTOB 113 TaKtrx Ky.nbTyp cpaare.n.nirrbr
oca>mca.inicb na xo.no,ny, B313e1Jjaaajlach B 1/10 oftema ripo3patmoro
OTCT051 II 3aTeM 11013T0p110 3amopa>K14Ha.nu1cb 11 oTTaliaamicb. BbIJ10
3aHo, tiTo TaKiim o6pa3om Tionytielmbre J1113aTb1 aKT1113Hbl B OTHOWeHIIII My-
cobacterium tuberculosis (1:300i ? 800) ir Mycobacterium phlei (1 ? 200?
2.4
111,01;j1EN11.1 AllT1111110TII1c013 ill'OT030111101'0
37
1 : 670), 110 ne OKa3b1BalOT 3ameTnoro AericTalin ila KyJIbTypbI Staphylococ-
cus aureus, Echerichia coli, Klebsiella pulmonum, Photobacterium
011b1TbI ycT.aHorm.,tin, trro au,eToir, MeTIIJIOBbril oralpT 34)111) 113a.neKa10T 113
.11113aT0B Tetrallymena aKTIIBLIOe airrit6al:Tepliaabnoe BeIlLeCTBO onnuation
npupoAbi. Ono COCTOHT Ha 75% 113 CMCCI1 11aCb1111,eHlIbIX 11 liellaCb1W,e1111b1X
cao6oRtibtx >kupnbix KIICJIOT ii na 15% H3 inerapa.nblioro >Kilpa II neilTpa.nb-
11010 cTeponnono2lo6Horo coed:13111mm
MaKKII nocTaumn 011b1Tb1 C NIbIllleff, 3apmenlibix Ty6epKyile-
30M, c nomotubto mcciponort cppaKtuili Tetrallymena, Ho no.nytiitil IleraTilil-
liblit KoTopblii aaTop 0613FICHIleT TeM, tITO Kitc.noTbi
C13$13b1BaJ111Cb B opralamme )1(11BOTIMIX ripoTeiniamti cPoccParnimucamn.
K aTomy HaAo Ao6au1iTb, t1TO B 011bIT13X in vitro aKTIIBBOCTb npenapaToa 113
Tetrahymena e3K0 rionitumnacb npii llpII6aBlchihIII kpomi mil Cb1B0pOTKII.
CJICJI,yeT TaK>Ke OTMeT11Tb, t1TO (1)IIJIbTpa1U151 tiepe3 ac6ecTonte cpti.nb?ripbt
Tame 110.11HOCTb10 climkaaa aKTUBHOCTb j1113aTOB 113 Tetrallylllella.
HaK011e11, yEmem Ha pa6oTy Xora (1943), KoTopbcil, aapanosi Trycho-
monas vaginalis Ky.nbTypbi TK'aHeil ne.noaellecEoro n.non,a icypinioro 3apo-
Abnua, NIOr yCTaHOBIlTb, LITO 311I >kryTilkoable 11pORBJ1210T 110J10)K1iTeJlblibIii
XeMOTp011113M K 3KC11.11aHTI1p0BalifIbINI Timm. TplixomoHaRbi noape>KAa.mt
ciratiana 31111TeJIIIaJIblfbre KJIeTKII, a 3aTem coexiiinTeAbHo-TxaHHbie (P116p0-
6.ilacTbi. KoHetnioe 'BbINInpanne K.ileToK TKaHeubtx Ky.ribTyp BbI3b1BaJI0Cb HC
mexanittlecKilm noapemmetmem, a TOKCIItleCKHNIII npoayi:Tamil, abifi.e.anembimil
cp.nare.rmsrramil. (1)11.nbTpaTbc cTaimix Ky.rib?ryp Trychomonas vaginalis TaK-
>KC noape>mcaan Timm' m.neKonliTatomilx 11 Eyp.
HaKoneit, COBCON1 ne,ilanno LICH (Chen, 1955) no.nytum awriiOnoTHK 113
tincpy3opiiil ,napamemiii (napameumil 34), Ko-ropmil H3611paTeoblio AericTno-
i3aJi 1111 ,upyrtie mom Toro )Ke polo.
Bce nplineiceHlibie cPai:Tbi pa3's-i1Is-110T Nlaj10 113TM-1111311i Bonpoc 06 an-
Tit6HoTincax npoTo3ormoro nponcxommemin (lc KOTOpbIN1 OTHOCIITCH npenapaT
113 u1i3oTpirrianym) ii Tem cambim ;calm- octioaamie pactimpuTb 1101ICKII an-
T1-I6n0TittiecKnx BeIlLeCTB. 0,L1HaK0 Bee npitae,RenHble cpaKTbi OCTaBJ15110T OT-
Kpb1TbIM Bonpoc, KOTOpblii 6bIJI T10,111151T B Hatiane 31011 r.riaabr cym,ecTaytoT
JIII ameaoKaTa.iniTlitiecKne aemecTaa y wil3oTplinanym H IINIelOT J111 01111
miattelme npii ero KyobTnanpoaamiti. Ha DTOT Bonpoc, nmeionmil Otleflb 6o.nb-
moe 311atiemie npit II3rOTOBJle1IIIH npenapa-ra, Mb! ,11.011)1(11b1 C 60J113111011
neposrrnocTii OTBeTIITb rio.rimirre.nbuto. XOTH B anTepaType 3101 aoripoc Ma-
.10 ii3ytieH, ace >Ke B OTHOCHTOJIb110. HelaaHo ony6zukoaami0il pa6oTe (Sub-
barow Little, 1949) yKa3aHo, HTO JiH no.nytiemin icy.nbTyp unc3oTptina-
t1ym Ha npeg.no>KeHHoil limn cpe,/ite Tpe6yeTcz nocea Hecbma 6o.nbumro Ko.nir-
tieCTBEI TpIITIa11030M.
3TO noKa3braaeT, tITO 0,11.IIIIM 113 yea:milli ycneuctioro 3I3IITlU1 yAbTyp
5113./51eTCH aae,ccenne. HeicoTopoil nocemoti )1,03bI, 11111K11251 rpainnta KoTopori
ace )Ke ocTaeTcH Becbma 6o.nbwori II Bb13bIBaIOW,efi 3aKorm0e yalia.nenne NIIIK-
po6acoora, o6bilmo ripmmuunero K coaepureHiro ll1IbIM 3aKoHomeptiocTsim.
3TO caoeo6pa3Hoe Timeline mo)KeT 6bITb o6-micHeno, ripiiHnTb riinoTen
0 cyucecTaGuamni amne.noKaTaanTlitiecKirx, T. e. ciiimyimpyknutix pOCTOBbIX
BeILLeCTB, abLae.rinembIX 11J1130TpHrianym. TOJIbK0 ripti II3BeCTHOM ypouHe
3114X pOCTOBbIX Be1.11,eCTB B nuTaTe.nbHoil cpe.ue CTaHOBIITCH BO3N10)K1IbINI 311a-
pocT xy.nbTyp. B 3T0fi >Ice riinoTe3e HaXO11I1T caoe o&bncileHile ii
OTH0CHTeJ1bH0 60JIee tiem BO mHoricx Apyrax mitKpooprami3Niax
JIaTeifTHbI? nepHoA, KoTopbili nepe>knaaeT KmAaa KyabTypa
Korica B Hell HeJIb3H OTMeTIITb HapacTamin 'mum Tp1-rnaHo30m. ECJIH 3T0
Tak, TO Toraa npniceTcsi 3aKJ110t111Tb, tiTO y unnoTpitnaHym Mb! IIMeem ae.no,
no KparcHeil ,mepe, c ,/1.13yMH cPaKTopamir. C oxinm clmicTopom Tuna crnmy.ns-
TOpOB 11 C Apyrnm LlIaKTOpONI 1rHrII6IITOp1101-0 xapai:Tepa.
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
a
38
IIIPPElaII"I II B 'ICSIEKTE
CTiimy.nirpyiounie Bemema moryT fieficrBoBaTb He TOJIbK0 ita menu
TOM e ollfia, T. e. ne TO.116K0 afize.noxaTa.nirriineciiii, Ho II CTI0006/IbI 3IIRI/CK-
THB110 1341151Tb Ha mem coBepinemio Apyroro 311fi,a. Bbicxa3a1i1ioe ripeAno-
Jtmeaue HaxoiniT CBOO no,nnepfimetilie B ormcalinbix B airrepaType onbiTax
110 COBNICCTHONIV KyJIbT111311p013a/11110 Entamoeba histolyfica u SChiZOttypa-
11L1111 npiloaBfiewie noc..nefimix pe3xo criimplipyeT panirrire xy.ribTypm
ame6.
Kai( noxa3an Max PIAB3H (1942) 11 milorne Apyrne licc.neeloilaTefin,
BROMIC BepOSITHO npefinonmemie, trro napafiii3aTophl pocTa K.71eTOK
6.1113K11 K 11C06X0A1INIbINI pOCTOBbIN1 Baileemam 11 6fiaroonap1 aromy
cxoficriiy, ?HI', BKJ11011EISICb B o6meli BeMeCTB KJIeTKII, BbIBOXIT 113 cTpon 311-
311N1b1, 11C06X0AIINIble Ann Hopma.nbnoro myTpumeTotmoro meTa6animma.
33fiatia irec.ne,goBaTe.nn B npeAripint3Toil mom pa6oTe 11 3axmotraercn
1) B uefieHanpameintom noon6ope Taxiix ye.TIOBlIff CyLIICCT13013aIIIIR, npu KO-
TOpbTX B mneTnax un13oTpi1na1Iym Haxanaitriazoci, 61,1 Heo6xoximoe Beate-
CTBO?Hurn6HTop, xoTopoe MO,KHO 6bI.110 6b1 11C110.11630BaTb 13 KatlecTBe
aim-
6fiacToml1oro cimicropa, BBIuiy ero cnoco6HocTil 113611paTe:Ibiro HaxanaiiiiaTb-
CFI 11 113NICIISITb o6meii 3fioNatiecTrientibix KJICTOK; 2) B uezenaripametiHom
oronezemnr, npii H3roTowleinin npoTimpaxosoro atiT116HoT1nca, Apyritx. Be-
IlteCTB, T0pM035ILIIIIX Hair 1133pauiaiounix fi,eficTinie allT116J113CTOMII0r0 aK-
Topa.
I11,01;j1ENHA TI1'0T111101'A10131)1X
39
III ?.raCTb
HHOEK11,1451 14 PAK B ACIIEKTE HPOBJIEMbI
HPOTHBOPAKOBbIX AHTHBHOTHKOB
Hawn npemue TI macTosulute orthyrbi no 6BoTepannu 3J10KalIeCTBell-
1113IX onyxo.neil, pg HOBbIX H crapbix Bccne,goBalmil Apyrnx aBTopoB oTe'le-
CTBCHHbIX 11 3Ha41rreabHoe ittic.no 110IICKOBbIX pa6oT no Bj1119H1110
TCX NIIIKp060B Ha pax, nacTbio cotiepuieHHo 6eCCIICTeN111bIX c.ny-
nailitbix, Ho oco6einto ,mHoratmc.neHHhix 3a 110CJICAHHe rum, ior.aa ycnex
13HTI16110TIIKOB CTJI onemium?Bce 9TH IICC.11e,a0131IiIIR CTaBSIT nepeA HaNni
o6w,yio ripo6.nemy o B3a1IMOOTHOUIeHHSIX mmuy HexoTopumn iimpexumimii 11
3J10KatIeCTBelIfIbINIII 011yX0J1 5INIII.
4T06131 ?pa3o6pancsi B 3T0r1 CJI01KHO11 II noxyua, Rax MbI .N10>KeN1 Cy,a11Tb,
eute He pacxpuToil npo6fieNie, Mb! XOTHM cnep3a paccmoTpem fiericTinte He-
KOTOpbIX Haii6anee inyneintbix micpexintil Ha panitTite 3.noxatiecneHHbix
HoBoo6pa3oBaHini. B zwrepaType HmeeTcH HeCK0JIbK0 BeCbN113 rIOyLhhITeJlbIIblX
nintmepo3, rii.e intrit6iiTopiroe ?BaHHHHe iimpexu,HH Ha 3.noxatiecnemibie
BbicTynaeT AOCTaTOI-IHO SICHO, H Ha xoTopyix Mbl XOTHN1 OCTaliOBIITbCSI
ncapo6Hee.
Flepnim npiimepom moryT CjIy}KIITb Ha6aio,nemin BpaynuiTerma
(1929 r.), oTHocsunuecn K BJ1115.11-1H10 Mansipmf Ha 3J10KaileCTBeHHbIe OrlyX0J113
tieficosexa. IlpeAnocbiaxoci AJI51 9TIIX 9KCIIeplINIeHTOB CJIy)K11.71 II BbICKa3bIBMIIISI
nexoTopbix Hcc.neuoBaTefiefi, o no,umeneHHom 11.1111 nofi,o3pe3aemom aHTaroHM3-
MC maanplleil H 3.110KalleCTBeHHbINIII OflyXOJ1lMH. B 3T1IX Ha6zioriemmx,
oco6o orreHmacb pa/lb mamipitii, Kai( fi,..ruiTeabHo Texymeri mickexumi.
BpaymuTeini fieitim npiimaxamii mazapini 6 T51)KeJ1b1X paKOBbIX 60JIb-
11131X. noTrii y Bcex naluiewro3 Home nptrmum naa3mo1Uifi maanpmi elue uo
natia.na npncTyna Ha6fitoua.nocb yBefintieHne cene3emui ii ouiro3pemeimo Ha-
cTyna.na .peaxurin co CT0p0HbI onyxo.nit. B Happiamix onyxonnx Ha6filoua-
.Trach ritnepemiin Ha6yxamie, conpo3o>xuaBuniecH 6o.1sim11. BanbHbie paKOM
neiteHH H pexTyma )1(2.110BaJIIICI3 Ha 6oait H TtyBCTBO ?Haripmelliisi B o6fiacTH
onyxofiii. floc.ne HacTyrizeHtin mixopauotmoro neptiofia mecTHbie CHMIITONIN
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
40
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41
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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-C110d11 110E103111dOND II nUM `ijompiredo) 19.1.19110 ?NairodnioN 3 ounialutuda ou
end edamodm
-urn 0.1.13` igwoxdu3 nod dpuirgerou eirnmocjnin eennuundloc.:
nonguo xlcumfaiegor0irpou iindao LI IIm1111LI0H1313ic '11031411H01: 'g
endoied09ew nornen El 111711011191311 opeed onearcau 014< oj?(gr oilgs-z, .1.0)
edomodNi icwondeo 1314 dicIgelipi xiggneunddocern ungiouor woudont911.11e1
133)10111411 aneurrend xiirnungonenic Ilogomndomp ?D n num .14 ?J
`nonumredo ?g 'dci
'1111311013 noncod imocix)(1)-Leici rui?Icuixdiciolitil:931:31"IIJIIII INmw '11.0111111'11.0111111"I" opmcolv Ole101311191313)10 ISIIT1310(1)1Ill ISEHHELIIIdIOE
-IIM 'M91110E111W Harlin X113011111 IllfOXIc110 1311 11 MI0E1011'311 IllfOXSUO 1311 ISTICII3IRV
0110MUllte NOMOdIIM Ildll :131E41 111414311.1311 13N130E1 EH age
-elmnne 9i.e.Led90 .1.01cra113 `enrimaqllei uounnundiocern >1 gnemedgeog
:1131411DV (I 14V.1 II
917
? 1.,???????
9-?00080006 1-001?170 1-0-1-8dC1I-V10 ZIA70/c i,c)z eSeeIej ..104 panad v do 0 Pez!4!ue3 - 1-led u! Peq!sseloaCI
.111,{1, .0 a 61?1111.111161.10......... . maw-
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
00 0
?-????? ???.?-?????? ' ????-?? a ??. ? - 42.?????-?
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4
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48
our.vrHoE PA:31111TUE 3:uni.knErTBEHmax 011VX0:1E(1 tIE:10HEKAii
II,erICTBOBaTb Ha olumaxoBble Bum 6a1KHO 6bi.no npeano.nmnTb rum nepBoHanaabHom
alIaJI113e.
3. Hurn6irropHoe AeficTEme HexoTopbtx in-upexu,nii Ha pax CBSI3a110 c
Tem, LIT? Bo36yAnTe.rm 3TI1X Hmbentnii o6pa3por ?BeutecTBa, BAnsHoutne B
60.1113111er' 11311 MeHbIllerl Mepe Ii 13 Pa3H0r1 cTertelm 11361!paTeabHo Ha meTa6o-
e1I3m 3.110Ka4eCTBeHHbIX x.neTox, rtopman pante 11X KON1110HellTbl.
4. Mllxpo6H-11C1011HIIKH aHTH6J1aCTONIHNX BeIlleCTB 3HatIliTeabH0 6o.nee
mHoroo6pa3Hbi muorotmc.neHHbi, nem mHxpo5li-Bo36vAnTean mnpexunoH-
HbIX 60J1e3Hefi. ECM! B036ynnTeab 'xaxoil-an6o umpexunn co,aepnutT aHTH-
6.q.acromitylo (Ppaxu,mo, TO ninkexu,HoHHoe 3a6o.neBaHne, BbI3BaHERie JIM B
opraHH3me, nopaxcemioNt paxom, mcqxer conpommaaTbrn itHru6nTopHum
jlerICTBIleM B OTH011IeHlill 3.noxa9ecTBeHHoro npottecca. Ho aunn5.nacTomHan
(1)paxtu1 mo-ixeT coaelmcaTbcn' B He60j1e311eTB0pHbIX mmKeHHbIe B 3TOri nacTH (kaxTbi II Ilpe,a110:10)KeHH51
5113:ISHOTCH He06X0,3,11MbIMII npe,Inocbtaxamn npn paccmorpemin Jtasiee oallcaH-
11b1X Ha6.7110,11e1111fi Ha ,B,eficTBllem npomBopaxoBoro aHT116110TIIKa 113 1111130-
Tpimatiym Ha 3.1oxanecTsemibie onyxo.ln 11, B riepHylo onepez,b, Ha parmobie
nopzi:xemin ne.noBexa.
7.1 \Ii0110MEPH0CTII .1,EnCT131I51 1111130TPIMAI111010 IIPEHAPATA
49
IV nacTb
OBPATHOE PA3BHTHE 3J10KAIIECTBEHHbIX 011YX0J1E13
IIEJIOBEKA H 3AKOHOIVIEPHOCTH AEFICTBHR
.1.1.1H3OTPHIIAHH01-0 HPEHAPATA
C Toro momeHTa, xax pa3Hoo6pa3HEam annepHmewramH 6bum Roxa-
3anb1 aHT116.nacTommbie CBOrICTBa xyabTyp unt3oTptmanym, a cneuttaabHbie
Hcc.neRoBaHnn noxa3a.nu 6e3BpeAHocTb 1IJII ne.noBexa npenapaTa 113 3111X
xy.nbTyp,-Hanamicb ,ximminecxlle 1Ia6.1no,aeHnst, OCHOBHOri IteJIbIO KOTOpbIX
SIBJIHJIOCb yCTB1-10BliTb 3axottomepnocTH TeneHun paxa B yCJIOBIDIX cucTema-
Tnitemoro BBe,tteHnn 6o.nbHbtm npenapaTa 113 unooTpunattym. Icrunninecxne
Ha6Jno,n,eHtu1 OCylaeCTBJICIJIIICb 110,a pyKOBOACTBONI npo(1). B. D. JIHm6epra,
npocp. B. M. CBsiTymma H npocp. J-1. M. HHcHemna, HayitHbunt pa6onnixa-
Nut H. A. AH.ripeeBbtm, F. C. I01ainetu1, F. A. ,Ltpefiu,epom,
H. PyTKOBCKOrl, H. Llernc, F. E. M.apaHTH,n,H. McToplln 6o.ne3He1l, HarnicaH-
Hue 3TI1MH 1011111I11,11CTaM11, noc.npmm maTepna.nom. aHaon3a 3axono-
mepHocTe1i perpeccnn 3.noxamecTBeHHbpz onyxonen ne.noBexa noi-t 13.11112Ht1eM
npoTHBopaxoBoro a'HT116HOTIIKa 113 wn3oTpunaHym. Kpome Toro, B He.nom
pg,tte ,c.lynaeB MbI npn6eramt xoHcy.nbTaullnm npo(1). B. A. EropoBa, npock.
H. di. (1)aepmana, npotp. M. C. A.nexcaHApoBa,inpock. JI. M. PaTitepa. FlaTo-
moptPanormtecidul a1rarHo3 CTaBlIJICH npotp. B. T. TaamaeBbim, npock.
O. H. Flompncimm H npocb. 51. J1. PanonopTom.
OCHOBHbIMH (1)opmam11, npii KOTOpbIX lipIlMeHHJICH npenapaT B KJ1111111Ke,
6bum pax ry6bt H pax rpy,B,Hoil ?KeJle3bI.
Pax ry6bi 6bLn H36paH HamH xax tbopma OTKPbITOTO nopan(emni, ito-
cTyrutan B113yaAbHOMy Ha6molteHmo, HTO CO3,11,aBaao ,B03MOJKHOCTb ClICTeMa-
nitiecial KOHTpOJIIIp0BaTb JlerICTBIIe aHTE6Homxa xax Ha oar nopaNcemin,
Tax H Ha BeCb opramt3m 60J1bHOTO. Pax rpy,rutoil ?xe.ne3bi 6bLn H36pati xax
cOopma 3a1(pb1Toro nopmeHnn, npit xoTopoct 6o.nee nem npn dupyrllx tpopmax
6b111o aooTyrmo ocymecTBanTb Ha6.Tuo,aemin -He TOJIbICO KJIHH114eCKI4, HO H fly-
TM HOBTOpHbIX 611011CHrl.
Ha 11p0T51)KeHIIII Tpex J1eT 11011b1TaHH1 xy.nbTypaabHoro npenapaTa- B
KJIHHIiKe (1948-1951 rr. )1b1 Ha6.THoAa.Tm 24 60J1bHb1X paxom ry6m. Y
5 113 24 60j1bHbIX 34n1ewr ,ReficTBnn npenapaTa OTCyTCTBOBaJI Ha6moRaocn
B pa3Hoil cTeneHH 37 19 60J1bHbIX, 113 KOTOpbIX 11 IIMeJ114 nopmemte 3 1 cTa-
Atm, 7-Bo BTopoil It 1-B TpeTbect cTuunt.
1/13 73 60JIbHbIX paxom rpyaHoct )1{e.J1e3bI 3(I)CI)eKT ,1Ie1'1CTB112 OTCyTCTBO-
BaJI y 33 6o.ribHbrx. B pa3Hoil cTenemt &la OTMegeH y 40 60J1b11131X, 113 KOTO-
phix 13 Hme.rm 3a6o.neBaHne B nepBoct cTaamt, 23 - BO BTopoll H 4 - B TpeTb-
eft cTaxm. Oco6o c.ne,u,yeT OTMeTIITb, tITO npn paxe rpy,a,Hoft }xe.ne3bt Mb!
cTaini Ha6,JuoAaTb CpaBH11TeJ1bH0 6o.nee AJIIITe.71bHblrI 3C1X13eKT OT npHmeHe-
HIM npenapaTa Tarim? noc.ne Toro, Kai( KJIIIH111111CTb1. cTa.rm npH6eraTb
yaaJIeHIII0 OCHOBHOTO onyxo.neBoro y3JIa B npe,ttenax maxpocxonuneciut nopa-
?KBFIHbIX TKaHefi, 11p0I13B0,1.5I TaKoe cyry6o nanHaTHBHOB BmetuaTeAbcTBo
13 npouecce Henpepbmaemoro xypca BHyTplIMbnllet1HbIX mrbexurtil npenapaTa.
Fpynna 6o,,nbHbtx, xoTopan peamposa.na Ha turbexu,un npenapaTa CTOrt-
KIM!! np113Ha1Cam11 perpeccHn OTIYX0JIII H 0611111M 3T,U,OBJleTB0pIlTeJlbHbIM COCTO-
HHHeM, 6bLna BHOBb ocBueTenbcTBoBaHa xomitccHeil YneHoro CoBeTa
mmTepcTBa 3,apaBooxpaHelm51 COI03a CCP B 1955 T. mule TOFO, KaKno
4
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
r01.11
itirw"
50
06PATII0E PA3B1ITIIE 3.101Ai1ECTBE11111,1X onyxo.-tan tIE.TIOBERA II
oKoHnaHHH .neneHan HueKao 5 Holt 6o.-tee 3TH Ha6z1oAein1s1 ornicaHbi
HapHay C HeK0TOpb1M11 ,apyrirmit, Hmeiouilimft MeHMIII111 cpoK.
PEITECCITN PAKA Y5b1
Ha6,-HolteHHe 1
BoabHolt r., 48 aer. IcTIIIH/itleCKHrt ,l/far1103.. pa K HIDKHeil ryObt, rHCTO-
oorgtiecKti1-11.10CKOK.leTOritib1el paK.
.3Hmoil 1946 r. Ha HIUKHerl ryOe r10511311.1aCb 60p0,aaBKa, Koropyio 60.1b-
HO1l ripmicer Knooroft; Ha 7./TOM mecre o6pa3oaa.-tacb n3Ba. BecHort 1947 r.
nopa:Ketwbrii ynacToK ryobi obta yaaaeH 011epaTIIBHbINI IlyTeNI. CnycTst 1/2 ro-
B nHaape 1948 r. Ha M-CTe pyOua o6pa3oaaaacb .KopKa, KoTopan B ,aa.1b-
Heiltuem TO 11051B.151.1aCb. TO ornaJaaa. OCTaB.1S151 5138y.
Ciimnrombt nopaxceHnn (12 Niasi 1948 r.).
Ha mincHeil roe CjleBa. B o6.71acTH xpacHoil KailMbl-onyxam 1:1mOpo3-
110ii 11.10THOCTH, pa3mepom 1,0X0,5 c.f. r1pH outynbreaHHH nepmpepitHecKnfi
Kpail ee HeCK0.1bK0 BbLae.151eTCH ax 60.1ee 11.10THbIrl. Bce o6pa3oaaHHe Ha.a
yponem oxpy:Katouteil coH3Hcroff He abrcTynaer. 0KpacKa Toro nce Haera,
t1TO ii oKpyn(atoutert C.11131ICTOrl, HO maToaoro orTeHKa. HoB006pa3oaaHne
oKailmoeHo y3KHM aaanKom. Cnpaaa - Tpeuuma uniptmoil 0,2 cm, coy-
6141'0ff-0,3 cm.
KpacHan ryObt noKpbrra ynacTKamit runepKepaTo3a.
Y oeaoro Kpan poToBoil mem! Hmeercn pyOeu-cze,i onepann3Hor0
amewaTeAbcraa, 11p0113BeileHHOr0 ro,1 Ha3a.1 BecHoil 1947 r. rio notioAy SI3BbI
nocne o:Kora.
JIHmtpanniecKne nK110 utulerb no,u mimpocKonom, rpamma
npeamax 3AoKagecreennoa
6uoncupouauHoro uycomKa npoxop,Hr 8
B npenapare un,aliblee nonepetmo nepepe3aHHbte TH/KII. Tatum o6pa30m, jiiui
6110=1111 B3HTa A11111b paKOBOil 011)TX0AII, B TO spew' KK Apyrasi ttacrb
ocranacb HerpoHyrort B opraHu3me.
BTOpbIM BMCLIIaTe.lbCTBOM, KoTopoe !Blum mecro y 6o.abHoro K., 6b1A
Kvpc 6norepannu, cocrommueii B 111113e1(111151X ?npenapaTa. Ha npormKeinui
ACT K)TC TIPOBOXIACH ABa/K151-B 1947 11 1948 rr. B IlePBOM II BO BTOpOM
Kypce lurbeKuuu npenapara conpoumAa.nucb npe)Kae Bcero ocraHonKoR po-
en onyxwm, 3arem ee pummel-mem 11 pa3m5irtieHllem.
FlpeKpameHne Kypca 61torepanun conpouo?Kamocb uHatia.le cra6m11-
3a1tilCil npou,ecca, a 3aTeM B0306HOBAeHlIeM pocra onyxoon, Koropbffl BHOBb
6bu1 ripliocraHomeH C B0306HOBACHIleM Kypca '111TheKLIHrI. TaKIIM o6pa3om,
Aalutom caytme 11Nie.ri NiecTo cpeHomeH peeyntipyeAtoti peepecciat onyxo.111
IcrumutiecKu perHcrpupoualmast perpeccim onyxo.rui conpouo)KAmacb imme-
Heunem ee mopckwormecKoil crpyKrypbE lictie3.7111 3ACNICHTb1 3.710KaileCT13ell-
Moro Hou006pa3oBaHn1 11 11X mem 3a110.11H11.1111 ,H0pNIaAblIbIC TKaH11.
DTOT napaihneamm pa3sirr1iu onyxarill II TIpOBOAIIM01-0 Kypca
npenapara-nporpeccumbirt pocr flD1i orcyrcruint 111-rbext1di H o6parHoe
panurne onyxamt BO upem BBeaeuna npenapara-3aCTaBaHlOT npH3Harb
38611CIIMOCTb KAIIHIFIKKOr0 BbI3a0p0BACH1151 60AbH0r0 K. OT npoue-
AeHtioro Kypca 611oreparum KK extHcrueHHoro .Tietie6Horo cbaKropa, o6ecne-
1uumuero B AaHHOM C.Thyllae 110AWKIITe.TIbHbIrl IICX0J1 3a6ozenalum ITAOCKOKAe-
T011HbINI paxom, 3a6o.rieualum orurgeHHoro ,I1OBTOpHbINIII 611011CIIHNIII.
Ha6.7110Ael11151 HaA 6o.rtbHum K. 3acrammor o5parurb B1-111NlaHHe Ha
cAteAyroutufl (palm nouropHoe nue,fliernie npenapara c mrrepuazom B He-
CliOabK0 Mecytuea conponmiazocb 110.1031CUTeAbnoti tccuit(epo:zurtittecKoti
peaKuHeil, nureAcrune liero Hacrynnao o6parHoe panirrHe onyxo.Tin rip])
noeroptiom Kypce lurbeiutuil Talc }Ke KaK II B nepeutinom Kypce.
ilposeaeHHoe Ha6d-1uo,useHne 1103BOAHeT 110CTaBlITb Bonpoc: o62/aaaer
OHT116-1aCTalflia51 cy6crautfuit tuu3orpunantweo npenapara il.itAtynti3upyotaeti
enocoonocrbio?
Y 6o.naoro I. 110.109/CUTeIlblibla 80081CT ,RefiCTBIIH npenapara 6bIA noAy-
fieli ascacabt Ha nporszpKefuni 2 aer c npommyrKom B 7 mecuuseu me>Kay
.113YM5I Kypcamil iarbextunt
YCJI0B1153 BBeileH1153 npenapara 6buni TaKOBbI, T0 npir Hampuni B Hem
awrirreHHoil CTIOCO6HOCTII liwbeKgiIII 6e3OTKa3H0 AO.TDKHE 6bIAII nometib 3a
co6olo cpopmupouaHue B oprammme Hmmymrrera. B nepuom Rypce B 1947 r.
60AbH0r1 noolyqaa npenapar meAHesHo uHyrpumbnuetulo B reqemie 9 me.csi-
ueu. Bcero 6bulo cae.naHo 57 InfbeKu,Hfi, nocze ger? Hacrynna nepepbn3 npo-
ACCDKIITeilbHOCTMO B 7 mecates. 3arem IIHIeK11,1111 6biatr nosropeHm cHona C
110A0>KIITeAbHbINI pe3yabrarom. BOAbHOil B nepuom xypce noavtnia ,LLOCTa-
rottHyto Ao3y npenapara napsHrepaabHo, T. e. nvrem, Koropurt Hallaytauum
o6pa3om 06ecnetu1Baer aHrHreHHoe pa3Apa4celnie opralumma.
Ecali 110.71b30BaTbC51 11MMyHoJIorliqec1cI1ujj onpe,aeoeHugmH, TO 11OBTOpHb1fl
Kypc lurbentuit npouneaemudi 4epe3 7 mecsutes mime nap3HrepaabHo,
npucrasz51.1 C06010 KK 6b1 peuaKuuHauluo, npu Koropofi, KaK xopoino 113-
BeCTH0, aBTUTeJIackoplupylorcs B Becbma BbICOKOfi creneHit, Aa)Ke B pecppaK-
TePlibIX oprami3max, OTAIMIOILUIXCH HeCII0C06HOCTb10 o6pa3osarb awnrre.qa
nepuutmom unKae Hmmymmaului.
cDOTO 2. Bon-
Hort F. 14 V.48 r.
FlicTo.norimetKoe
apoelpie 0.11140f0
113 yttacTKop ru-
nepKeparoaa, B351-
Toro npli 611oncipi
nepe.a. Hatianom
Kypca pwbermin,
tIpc3ntanafill0 rycTan
oanabilan tintPitabT.
paling COCAIIIIIITC361(0..
'manna
npyrab11111 nacTnamn C
npumccbto 11c60abtuoro
noangecTna nom.
mop(Innax nacp ac11-
1101{11T013. CpCAII
tlinabTpara pacnoaa-
ratoTcn aTunnnecnne
TSUIZII it ritcaaa Rae-
Ton oaocnoro ann?
nponnauna-
minute Timm, n paa.
MAX nanpanacininx B
uelirpaabnoti riacTit
anttreattaabnux RWIII-
nettcort - oporonenne
C paanurnen ;newly.
nom. Ha nepinimpun
- Bnacnne peanoro
anattroaa c ys1epett-
111,1313t ritnep-n napa.
nepaToaamn, plax-Tan
lintlthahrpanlin OCHODIA
Nano? 6 p a 3 it ta It ii
naetnawn, cpean no-
Topmx AMOCO mania.
TIPICCIOIX Ii3CT0R.
1130CliON:,.!TOtl
pan. Maaoc yacantic-
(Duro 1. nonbiloa F.
Hawlioaemie 1. n.11OCK0-
K.11eT01111bIr1 pa K 1111}KIICCI
ry6bt. 14.V.48 r. Flopa-
}Kelpie mixtueil ry6bi
nepea, Hatianom 11111)CK-
min. Onyxonb 4)116po3-
11011 11.110THOCT11, paame-
pom 1,0X0,5 cu, ?Karim-
11.110711b1M Bann-
KM. Cnpana - Tpewmita
B 0,2 CAI, ray6upoil B
0,3 CM. YilacrKit riinep-
KepaToaa noKpbmaioT
Kpacitylo Kanmy ry6bi
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
I 1i
11,
(1)oro 3, 4. B0.11bH0ii F. 14.111.51 r. Cnyc?ra 2 rop.a ii 10 meolu,er, 01 Hatia.na
InnenLai. lipimaKon anoKattecTBellitoro nopmeima He?. Koirrponbitoe rit-
cronorntiecKoe Bcc.neBoBaune noKaaa.no orcyrcrBne 3.nehtenroB anoKatiecrBeir-
Bort onyxonn KaK B py6u,e, ocratatiemca OT AllarBocruttecKoil 6nonom, TK H
B perBoBapnbix JulmtiariptecKux )Ke.neaax. TO nonowerme iie Bameminocb
B nocaep,poume rub'. ocmorp ? B anpene 1955 ro,Ra. nplianaKB
peux,amBa ii MeTaCTa3013 OTCyTCTIVIOT. CpoK Ba6.1uoenua 7 ACT
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
4114
clioTo 5, 6. Bonbitoil 11.
Ila6Ameinic 2. nJIOCKO-
KJICTOillibln oporonenaio-
with pax limner( ry6m.
8.V.48 r. Ilopaxcennurt
yliacToK ry6b1 nepeA. ita-
qanom Kypta itirbennit
npenapaTa. Paxonan ony-
X0Ab pantepom OKOJI0 1
CAI, oxpyAcena yrtaornen-
libINI inateTynalowint na-
AIIKOM =pinion B 0,2 --
0,3 CAL, n013CpX110CTb 11313-
313BACIla, noxpbrra CTpY-
nom. B noxieniocTiloil o6-
.11aCT11 ?Amicimyae.rt paa-
mepow?enpana 1,5X1,0
CJIC13a-01,0X0.5
flicTo.noriniecitoe crpOe-
iiiie nepeit
.nom Aequiin. r1noexox.ne-
Tolnihni oporonenalow,a
paic. ,E(An 6lionenit nee-
qua 1/4 'mem onyxane-
Berl 513B131
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(1)010 7 Bo.nbnoii fl. 1.X.48 r. no ogouttannn gypca
unlegunil npenapaTa. Kypc npan.o.vga.rmg c 14.V no
10.V1II.48 r. BO./IbliOrt npung.g 63 mrbegu,nn-107 500
eannnu, npenapaTa. Onyxoan neT. aro commute
lie II3M0111I.TIOCb II B noc.ne.aylontne rcabi flocjicjuillii
ocmoTp?B MapTc 1955 voila: npn3nagn peunanna
nail meTacTa3on OTCyTCTBy10T. Cp0K na6.Tnco.enng
6 aer 10 meenuen
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
tEl
-
Om 8. 601113110R P. Ha6.1notteinie 3. linocKomerottiturt oporonenammtil pax.
24.V.49 r. rlopmenite ittoxitert ry611, nepeg Hatia.norst turbexuat npenapara.
Onyxoneooe o6pa3oBanite itmeeT pantep 1,5X1,0 cm, B r.ny6toty npoutynbt-
BaeTcst tia 1 cm, B ueurpe ? cyxort crpyn Bentititmoil 0,8X0,5 cm, 13 npaooft
110A4ellIOCTHOR o6n3cTit ? aural:myna 2,0X1,2 CM
(DOTO 9. B0J1b11011 P. 4.V1? 49 r. rliCTOJI011itleCK0e crpoe-
tote onyxonti nepe,a, ttattanom nementist. Ibioctcome?rotniurt
oporotteaalouutri pax. Mame yaemittextte
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
CDOTO 10. BOJIbIlOrl P. Cnycrsi 18 midi OT Hatiana actic-
min, Horne 15 ifirbeKunfl (15.V1.49 r). Paamcp Ho-
pmewin ocTanca TOT ?ice (1,5X1,0 Calf)
4:1)wro 11. BoabHoff P. CrlYeTfl 24 AIM OT Hatiana
Kypca nwbeKtillii, nocac 23 mrbeKuifil (24.V1.49 r.).
Paamep nopaaceuna OCTaCTCH TOT }KC ?
1,5X1,0 CAI, na noBcpxllocTH cro ? 2 upyrfa,
paamepoNI mom ? 0,2X X0,3 CAI, wropoff ? 0,5X
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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(1)oTo 12.
OOTO 12, 13. Boabnoil P. 1.1)C49 r. CnyeTH 3 me-
tHua OT Hatiana netlennn, nocae 67 nulemInfi. C)ny-
xoan Het Fla mcTe 6bunuero nopmemin yray-
6aeHne, noicpuToe HopmaabHoil -cnnaHcToil o6onoti-
Hofi. CIIHMOK 12 cateaan Ha onepanHoHnom cToae
nepea KOHTp0A6110fi 6noncHeil
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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[11113'.'
(1)oro 14.
BOJIbltOrt P
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Om 16. BOJIblI011 P. 1.1X.49 r. KoirrpoabHoe nicroaorimecHoe mule-
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para. 9nersieirr0n anoHatiecreeHHoil onyxonli Her.
flocjiejuice OCI311,11eTellbCTBOBalllIC 60Jibl(0r0 10 111.55 ro.aa: ry6a H xo-
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JIIIM4)0y3.T1b1 IIC npoutynbmatoren CpoH 1,a0a1oaemi11 5 Her 10 mecHueB,
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 ? CIA-RDP81-01043R001900080003 6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
,
cDoro 17a, 6. Bonbnoil JI.
1 a6nlopenne 4. Ilnoeno-
xperotnibifi oporonepaba-
anal pan. 12.1V49 r.
Onyxanb paamepom 1.5X
XI,25 CM. BbICOTOr1
1i I CAI. flopmenne I3epx-
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nentoeTnori o6nacTn
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pumcPoyana paamepom
1,5X0,75 CM ii 0,8X
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
CIOTO 18. BOAbIlOri 19.1V.49 r. flepeit ottoncitert.
cnenan na onepattnottnom cTone
cl)oTo 19 BOAblia R. 19 1V.49 r. MoNtenT 6noncito. C1111510K cne.nair
na ORCpAUHOHHOM CTOAC
00TO 20. Bonbitort J1 191\7.49 r BtApenunta AAR 611011CHH cermenT
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(1)0To 21 BOJIbiiOri JI. 19.IV.49 r. 1-ncTonorntie-
cKoe crpoenne onyxonn 6onbnoro .n. no .netiennst
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4) JnimcpaTHHecKnil y3e.n cripaBa, HmeBwHil npH3HaKH KaHKpo3Horo,
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
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uecca o6partweo a3811T11.2 011yX0:111, KoTopbril (1)11KcHpoHatt Ha cHnmKax
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NIONieT, u 110j1 B.III1511111eM pe3Koro y.gyfluieunn 6o.ge3H1r, cHaflana cTa.n npunn-
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12 anpean ?nponycK
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TOT nepito,a, Kora perpecci1H onyxo.nit etue He aaKoHtni.nacb, conpoHmKaa.notb
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Ha ? 6e360J1e3HeHHail I13-b513BJ1e1114a51 011yX0J113 paamepom 1,2X1 cm, c yron-
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 ? CIA-RDP81-01043R0-01900080003-6
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olwATHoE pA3i311THE 3:101 HEcT13EIll11Ax 011yX0.71Efl LIE.710BEHAIi
PaHee, Ao natia.na .neHemm, nporpeccnpoBaHman xpimora B npouecce
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cm K. neAaror).
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paKoHoff 60.11e3H11 Ha npoTsmemm Tpex JICT CBIIrkeTeJlbCTByeT 0 TOM, IITO B
Ammom czytiae nirbeKummit ripenapaTa AocTilrHyTo mannitHecKo'e BbI3A0p0-
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1MOCKOKACTOIlliblfi paic zaR0000011 C13513K11.
B Mape 1945 r. y GombHoro nomnmacb napacTaioutaH xpitnoTa n
Tem 6o.nb npn r.noTatinn. B mone Alecsme Toro )Ke roAa riicTo.normecimm
licc.nuolfainfem 5b1.1 ycTalioaneit naocKoK.neTotnibni pa K c oporoBennem.
B moire? mane 1945 r. Go.nbHoil npuliom Kypc penTrenoTepanntt no
KyTapy, 31 cenc, Bcero 6200 r npoTH>KHo-cppaKunomipoHaintbim NIeT0,11,0M.
01040 ro,u,a, T. e. /1,0 moan 1946 r. 6o.nbuoil HyBCTBOBail ce6H 6.naro-
nonyntio. rOJI0C BOCCTa11081111C51. Kjiniiiiqecxiii OCIMOTp noica3bma.n OTCyT-
CTBIle orlyX0J1Ii.
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Aocamie o6Hapy)Kano pe1uau6 patco6,96 onyxwitt JIeB0c1 ranocoHoft CB513K11,
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TaK KK TiepBbirl xypc AnyneHnsi BbI3BaJi OC.10)1(HeinI51 paAnommepmliTom
11 pa1llo3nnTemiTom. B CB5I311 C 3THM 60.11b11011 lie no,u?nexcaa IlOBTOpHOMy
o5ay1eHino petiTreHom 11 paAnem BO 1135e)Kam1e oTeKa
11 fteKpo3a OrlaCHOCril ocTporo HeKpo3a KOCTII He.THOCTII, a TaK-
ie BB11,1y pe3Koro CHI1)KeH1151 tlyBCTBIETeJIbI1OCTII 0r1yX0.111 K 11OBTOp11biM 06.w-
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Li 51. KynepmaHom.
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Kaweab H 60.71B HpH rnoTaHHH. IlpH zsipunronormecKom HcczeiloBaHlin
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ropTaHn.
15-ro aBrycTa 1946 r. 60.nbilomy HatiaTBI HirbeKunn npenapaTa.
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GoabHomy npoll3BoAH.THIcb BHyTpumbuuetnro, B HroAHHItylo
06J1aCTID, Quiff pa3 B CyTKII npenapaTom amport moxIcimicautm. Bcero c
15 aBrycTa no 30 oKTHGpft 1946 r. 5bizo ine,neHo 14 425 eiummiu B 65
nwexB nponecce larbeKuHil nyTem .napHuranorntiecKoro Hccoe,aoBaHHH own
ycTaHoBneHBI H3meiteHHH, cupoKarfuntecH B c.ne,ayloutem: CJI11311CTa51 060-
3A1WH0MEPIIOCTI1 ,1IEnCT131151 LU1130TPr11A11110r0 liPEnAPATA
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Ba.110Cb. Kpaii JIeB01"1 OB513K11 CTaJI CB060,11,1IbIM. Ha MecTe paHee Ha6.1noAaH-
aterocH Ae()eKTa cB513K11, B rzy6HHe ee, o6pa3oBa.ncH HemulBH1 py6eu,.
ropTan ocTaBa.nacb xopowo flOUBIDKIIOfI. Fo.noc nocTenenHo CTaJi
? Cy6-beKTHBuble ouLymetnin oo.au npn r.noTaHHH, Kamm:. u nepweime
B rope liCtle3J111. HaCTyIII1J10 immtiftlecKoe Hb13,1t0p0c.nenue.
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no OKT5i6pb 1949 r., T. C. B Tenemie Tpex J1eT, Ile o6itapy:KH.no amix 61,1 TO
1111 6bt.110 ripmaxoH peunAlma paKoHoil 60J1e31111. K. neer roam,
npuJiHpiiiiro.norlitiecKom IICCJIWIOBa111111 IIa rOJIOCOBbIX C13513KaX ire o6napy-
)KnHaeTcH npn3HaKoH II0J1,03pHTeJIblibIX B OTHOUICHHH paKoHoro rtopmeHnsi
OoLuee cocTomme K. ocTaBa.nocb 13110.T1Ile y1I,OBJIeTB0pIrreJibilb1M.
AHa.an3 KAHHHgecKoro 1[a6..rno,ReH1iH nut 6o.nbumm K. 1103BOJIHeT oTrae-
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noTepamm, B Hat1a.11131-10r1 ero cTaAmt ? oKa3a.ncH 6b1COIC0 11118CT8UTCAbliblAt
K /tekTB1110 611011pellapaTa, HTO BbIpa3I1J10Cb 110J10>KIITeJiblibiM KaHuepoTepa-
IleBTlitleCKIIM 344eKTOM, B pe3yabTaTe npineAwifm K ncne3HoHeHmo ripH3-
naKoc. paKoHoil 6o.ne3im Ha 3 ro,aa, noc,ne tier? 1-ra6.1nop,enne npeKpaTH.nocb.
2. Hcqe3noBeHlle paKoBou onyxo.rm conpommu.a.aocb perellepau,Heil
maim ? o6pa3oBalme1 Bilallmoro Ha raa3 py6u,a.
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meToAoH .neHefum.
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3T0M eCTb Heo6parnmbifi pe3yabrar 611orepArnm, aiteKuarublii
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nporpeccinmo panitaaacH, KaK 310 Own? ,rO natia.na HirbeKu,nfi npenapara.
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1/131emw TaKiim o6pa3om meromiKy Henam3ouannsi 6norepanitn, pa.noch
AOCTIlrilyTb y psma 6OJIbHbIX ,ELAHTeAblIOTO KAIIIIIPleCK0c0 13bI311.0pOBJ1e1115 51
6e3 paAnKa.nwtort onepaum ii 6e3 penTrenorepannH. Ho 3T0 6111.710 1103/111ee,
lioraa ItaKorm.ncH anbrr.
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Ha6ammetilie 12
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1leedle31,1 II craw'''. ritoranorimecioni ,nuartio3?cKupp. Flocrymma B
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um:y 3.111.1950 r. FlpH ?cm:rime ycraHomeno: 13 uepxnem Happolum Kunt-
palm ,npauort rpy,nHoli ?Ke.ne3b1 onpeAutHercH yn.nornemie 2,0X1,5 c
BbICTTIOM B mule mina; ymnomentle cpn6po3Horo xapaKrepa, twin noLITH
xpattesori KOFICIICTe11111111; B npaofl 110,11,N1bIWetHIGii o6ilacTH npoutynbtuaercH
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H 06011X 113,ILK,111041H111b1X II no/Hunotumbix o6.nacT51x A11N4150y331b1 He TipOW.Y-
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Tpanainioro npenapara.
IhrbeKtunt npenapam ii Tettenne &MUM!
BonbnaH rtpturma 1u1IireJ1bHbril Kypc unyrimmbintetnibix HwbeKunii c
28 cpespaan 1950 r. no 31 mapra 1951 r. B Tenenne 11 mecHueu 6buio
c.nanatio 260 tufbeKuml, B icoropbrx Hue,Reno 83 000 npenapara
VI mo,nutpliKau,HH ?cyxoro, nonyttetutoro 113 Kyabryp wH3oTpunanym, Bbl:
pauteHubtx Ha IiCKyCCTBeFIFIbIX HHTaTe.111311bIX cpeaax. floc,ne 13 mmeKunn
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itHapHbril pa3pe3 npasoll rpmnort )Ke.ne3bi, ma.neHne ortyxoon B npexie.nax
nopa,)KeHHbrx TKaHerr. IlaTorncronormtecKoe 3aKmonenHe cicupp.. Phrbexulln
npenapara 11?p0H3BO1TIZHCb me,ruiewto. CucTemarnnecKnii ocmorp 1101(33b1-
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MIOHOMEPHOCTI-1 ZEfICTI311 11H130TP1111A111101-0 IIITHApATA
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Kolute mapra no Bb130,0pOBJ1e1111H 60.11b110fi. floc.ne oKonnaltHH Kypca HIrbeK-
itiiii 16.V 1951 r., npH ocmorpe ycrattou.netio: o6e rpy/whie mce.ne3ba THna
(1)lI6po3noil macronamit; py6eu, 6e3 otiarou ynnor1Ie1r41; B o6onx numbt-
weintbix unaLuntax no 11e60J1bWOMy (0,75 cAt), 11.110T110BaTOMy 40y3.11y.
4epe3 1151Tb ACT (B anpeze 1955 r.) ycratiou.neHo: ,LI,. 3Aopoua, rpy,u-
Hag ?Ke.ne3a coxpanetta, npit3HaKos peusumlua H meracra3ou Her.
30 auryora 1955 r. R. 6bhna ocuHaere.moruouatia cneulla.nbuoil KOMHC-
Clleil rIpe310,nria Yitenoro COBeTa Mutnrcreperua 3,/tpaBooxpaHemin
(.CC P. komuccust KoncraTHpoua.na: ?lipatlaH mo.notmast nce.ne3a itecKanbKo
lienbwe omit. Ha rpalume Rapp:I-mix Kuaapairrou HmeercH
msulatil, noRuiplultar, 6e36o.ne3HeH11b1rt, 6e3 yn.noTHeimil. 01IyX0.11b B iKe-
Jte3e He onpeu,e.nHercH. 3aKmonetine: 6o.nb1la1 npawritHecKH 3Aopoua, peuu-
;ma onyxwm Her, ?meracra3bt He onpel1e.nmorc51?. CpoK Ha6mo1ieint5l ?
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BanbtlaH 1--aa, 52 mu. IcrituuttlecKnii iti1arHo3: patc npaaon apyallon
.71CC.1e3b1 I cranun. rilcronornnecKHrt ? cicuppo3Hasz adettokapt(totoma. B OKT51-
61)e 1948 r. 6o.r1bt1a1 c.nyHarwo o6Hapy?Kma onyxo.nb B npauoil rpy,RHort mce-
.1e3e. B MOMelIT nocryn.neting B K.1111HIIKy 26.X1 1948 r. B npauoil rpy,twoil
H:e.ne3e-21,tul4y31l0e yn.nomeHne pa3mepom 1,5X2 Cat, B ueHrpe 3Toro yn-
:10TIle111151 npoutynbtuaercH y3e.noK 0,75 Cat B Allamerpe. B npauoft
iuetiiroi unawme-2 .ntoupoy3.na pa3mepom 1X0,5 CAI 11 0,75X0,4 cAt. 26 Ho-
516p51 1948 r. itatiarbi uHyTplimbrulenHbie Htnexulut npenapara. 3.X11-6Hon-
C112: licceneH ytlacroK onyxwm -pa3mepom 0,8X0,4 C3.1 (V3 onyxwm). rll-
cranormgeme 3aK.rn0nein1e: cKlippo3Hasi atteHoKapunHoma ((Imo 46a, 6, B H
47 a, 6).
Hirbetuunt npenapara it Tegentte 60ne3n11
Bo.nbHasi F. npm-m.na 3 Kypca larbeKunri. tlepubiri -Kypc A.nihrtcH 4 Nieca-
ua: c 26.X1 1948 r. no 31.111 1949 r. KoututnecKoe Ha6.rno2J.eline .13 npo-
uecce in-rbeKutul noKa3a.no He ymeHbwelute onyxo.nH, a, Hao6opor,
yBeJnrie-
Hue: Hepe3 Niecgu, pa3mep In-uktmbrpara B o6.nacru py6ua ,noc.ne 6Honcim 6bIA
paueit 2,5X3 cm; nepe3 mecsiga noc.ne 42 turbeKunil (92000 edtutHHu.) HH-
cpa.nbTpaT jtocritr pa3mepa 3,5X4 cm; B TIORNIbIWet1Hb1X unawmax rimbrutpo-
ua.nucb mgricHe .nitOoyinbi 0,5 cm B nuamerpe. 27 51Haapa 1949 r. npoune-
Jtelta Bropilm,HaH 6tioncit11, npti Koroport meet-tem noczeonepatwoHHbtft py6eu
ii
yn.noTHemie Ha iece 6brumert nepHort 611onctm. riptr eticraitoeuttecKom HC-
C.11e)1013311H11 y,asa.neHHbtx TKaHeil 'KM-IX-ZOO tiptiattakos anotcattecreetutoeo
1-108006pC1306atit151 He Handel-to: o6Hapy}KeHa Kaprima KIICT0410171 macro-
nartm. Flpu Ambiteilunix ocmorpax KoHcrarnposano (27.11 1949 r. n 31.111
1949 r.): py6eu, 13 xopowem c0d-rom1fln-1, ymnorneintil Her, .In11m4p0y3.nb1 He
npontynbtualorcH:
31 mapra 1949 r. nepubill Kypc mrbeKunil 6b1.Ti oKomeH. BalIbH 3H. no.ny-
ilium 283 000 exumnu npenapara. Cnycm 9 we IIH'beK11,11H 6b1J111 BHOBb
HI-
TK Kai< 4 anpez51 B o6.nacm py6Ita 6bur o6napy)KeH ynacToK yn.nor-
lieltIlH pa3mepom 1-1,5 Cat. Ha 3TOT pa 3 Hirbextunt npo,uo.ma.ntrcb no 3 au-
ryora. BanbHaH nanynit.na 59 000 ensinuni. Yn.noTHeHHe B py6ue ymempuni-
J10Cb II 3aTem 4 aurycra KoHcrarupouw-to: ?py6eu, B xopoluem COCTOZHIIII>>.
1,11113eK11,1111 6bIZH ripeKpaw,eHbi. BO.T1b11351 ocrainema no Ha6modtteHHem.
pe3 31/2 Alecau,a 18 I-1?516p1 B ueHrpmbHoil Ham py6u,a o6Happ-KeHo
yflnOT-
1:
Ii
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
78
OGPATHOE 1'.13BIITHE H
HeHlle 4nt6po3noro num 13 1 CA/ B Anamerpe. 13b1JI naturr III Kypc 111113eK11,11r1,.
KOTOPhlfi npoHo.rma.ncst Ao 20 anpe.nH 1950 r. B Tperbem Kypce 6oAb1Ia1 no-
ay-glum 101 000 e,aminu npenapara. Yxce cnycrsi Atecnu (21.XII 1949 r.) yn-
.nomeHHe B py6ue ncHe3.no. flouropHbai ocmorp 6o.nbnoil no oKomanun 11111)-
CK11,11fi 1103B0j111.,1 OTNIeTIITb B ncropnn 6o.ne3HH OTCYTCTBIle np1f311aKon peun-
;um nan meracra3oH 4.11 1950 r., 22.11 1950, 12.IV 1950, 22.XI 1950, 17.1
1951. B Atavre 1951 r., TO ecrb cnycTst roa it -mil mecHua 11O py6u,om o6na-
py)KeH naornoHaTbril y3eA, 1,5 CAI B Anamerpe. HaHar 4-ii ?Kypc mrbeKunii ii
o,aHonpemeHno 30 Niapm 1951 r. HcceHeH ocramunfIcH OT TICPBbIX 6noncnii
py6eu c noximauteil TKal1b10 ITY,R110fi ?Ke.geni.
llpn rucro.nornqecKom aHaan3e pa.neHnbix maneil nnKaKnx npuanaKoa
pah-oeot7 onyxalit He o6Hapyyceno. HITheK11,1111 B CB51311 C 3TIIM npeKpatueHbi.
FpyAHasi )Kene3a coxpaHena (ckoro 48, 49).
30 aHrycra 1955 r. cneunaabHaH KONHICCIIH flpe3nAnyma YHenoro C013C-
MilmicTepcTaa 3,npaBooxpaneHHH CCCP, OCB1111,eTCJIbCTBO13aB 6o.nbrryro, yc-
Tattonnna: ?o6uree COCTOH1Ille 603bH0r1-13110.7111C 3111,0BACTBOplITCJIbH0C, ?Ka-
ao6 He npea-bsumHer. Ha rpannue HapywHbix Kna,apaHroB npauoil MoJIotIHoii
mcwie3b1 nmeeTcH JIIIHeI1HbII1 nonepetnani py6eu 12X14 cm, nepexo,Inumil Ha
rpyA,Hylo cTermy. Py6eir M51rK11fi, 110,11311)KHbIli, 6C360J1C311011HbIli. 011yX0J111
11 Alumpoymon He onpeARAHeTcH. 3airoloilernie: fIpaiamecK11 3,rropona, pean-
Ana onyxwm HeT, ?mencranT He Bb15113j1eHbI>>.
CpoK Ha6,7noaeHHH-6 .ner 9 mecHugH.
Ha6.11,oaenHe 14
BOJIbHaH C-an, 35 AeT. rIpir nocTynaemin B xanfuncy 24/11 1949 r. B Ac-
Boil rpy,RHoil xreae3e? ynaoTHemie rpo3AeHlumoro xapaKTepa, pa3mepom
3 X 2,5 cm, B ueHrpe ero Hbicryn B BItaeiuitna, nJIoTIlbtfi. B Am, nocrymennsi
Hagan! HirbeKunn npenapara. 4epe3 13 Audi ? 6noncuH: HcceHenne nopa-
;KeHHoro ytiacrKa rpyivtofi .;Ke.ne3br. IlarorncranornHecKHILluarHo3: KUCT03-
ttasi Atacronarun C yttacriaLitzt tipe3ebticaeitio 110a03p1ITC./lbHblAllt 710 6.1acro-
Ataro3H0dity (palcoemity) nepepawcaemuo.
Ihrbemin ,npenapaTa ii 'requite 6one3nn
BOJIbHa51 npHnsura Aaa AJIHTeJIbHbIX Rypca uHyrpHmbaueHnbtx surbeKunfi
C nepepbmom B 11/2 mecHua. Ilepnbal Kypc?c 24.11 1949 r. no 29.111 1950 r:
B TeneHne 13 mecsmeH 6anbna1i nanytmaa 66 000 eammu, npenapara. BTopoit
Kypc?c 18.V no 19.XII 1950 r. Bo BTOPONI Hypce 6bi.no HHeueHo 15 500 e,an-
Hnu.
4epe3 21/2 mecHua OT Hatra.na HHICK11,I111 n Hepe3 2 mecHua nocae 6non-
Cliii npn ocmorpe 60.11bH0r1 12 Ntaff 1949 r. nailAeHo: B .neHors rpy,aHoil
ae3e orAmbHue ?Harm macronarun, B AeHoil TIOAMbrUle4HOri 06J1aCTH
c1oy3e.n 0,5X0,75 am; B arena HaLuunotHrtmorr o6AacTH Taxa )KC y3eA, Ic011-
CHcTeHIIjJg o6onx y3.71oH THnntmaH A.nH paKoHoro meracra3a. B npouecce
AaAbHeilwero HHeAeHnH npenapara KanHntlecKaH KaprisHa 113N1e1451eTCH 11 npn
noc.ne,nyHmunx ocmorpax (1 VII 1949 r., 29 III 1950 r., 5 VII 1950, 6 IX
1950, 6 XII 1950, 19 XII 1950 r.) ormeHaercH; 'py6eu B xopomem COCT0511111/1,
onaros ynaorHeHnst Her, JIHM4/0y3J1bI He uponrynbmaroTcn, icamre-An6o Ran-
HbIe, yKa3bmakaune Ha peun,ans 11 meracra3bI, orcyrcTuyroT. C 30.111 no 17.V
B 6bIJI cae.naH nepepbrs. C 18 mast Kypc 61IJI B0306HOBJICH
Jr
19.XII 1950 r. noc.ne 379 surbeKu,nil 3aKomell. Bo.nbHasi no.nyinma
81 600 eAHHnu ,npenapaTa. 1-1pn ocmorpe, onycrsi Ana roAa n RHa me-
cHua OT nocrynaeHHH B 'KJIIIHIIICY (18 IV 1951 r.) ycrauomireHo orcyrcrune
npn3HaKoH peun,nna win MeTaCTa3013. DTO 110J103KeHlIe ire 143MeHIIJI0Cb 11 a
3.?Konomm0cri I ..1EIICTB1151 1111130TPIHIAII1101.0 IIPEHAPATA
79.
anpeAe 1955 r. fpy,anbse }Ke.ne3ht coxpaHeHm. 13 ceHT5r6p5i 1955 r. KOMIICC1151
ripemmilyma Ytle110f0 COBCTa Maunicrepma 3ApaHooxparieHHH CCCP, oc-
nuAeTe.nbcruouaH 6o.nbuylo C., abutecza 3aKinotieHHe: C. npaKTHHecKll 3,RO-
poua, peuumma onyxo.nu Her, meracra3b1 He onpme.nsuoTcH?. CpoK Ha6mo-
;tenns1-6 ACT 5 mecnu,eu. ((Duro 50 a, 6, 51).
Ha6ameinte 15
Boabnan B., 38 Aer. KAHHHHecKnil Auarno3: 0116poaaeHoma Anon rpyi3.-
noil >Keae3b1 c nwro3permem Ha palcoeoe nepepomaenue. rticroaorligecKnii:
aaeHolcaptylHodua.
111)11 nocTynaeHrm B KAM-1111(Y 15 aurycra 1947 r. o6e rppumbie }KCJ1e3bI
liCCKOJIbK0 4m6pomaTo3Hbl. B aeaoil rpmnoil lice.ne3e B HappKnoil ee Ham,
!la rpannue Bepxnero n umnero Kaa,upawra npoutynbumercH onyxo.nb xpsi-
=Boil Koncncrenunn pa3mepom 1,5X1 CAI, 013aJ1bH0c1 41opmbr, T10BI1)1(11a51,
cnasinnaH c napemmoil ?Ke.ne3b1, HO He cnamman c noAae)Kaw,eil TKaIlb10.
B JIeB0r1 nomibturetnroct o6AacTir npornynbumioTcn yHunmemibre
Y3J1bI.
25 anrycra 1947 r. 6o.nbHoil npo1I3HeAeHa 6uonctut, Aim tiero` HcceHena
1/2 Haub onyxcon pa3mepom 0,75 X 0,5 cm. 1-ncranormecKoe n3yHeHHe o6na-
ppKu.no aaeHoKapt(tatodity c nepe3Ko ubipmesmoil a1ran,nH3Heil )Kezencrbix
Tpy6oHeK H c efisHHIIIIHbIMH MHT03aM11 B snirre.nisaambix merKax.
C 20 aarycra 1947 r. 60J1bH0r1 Hagar Kypc mrbeKunrs npenapaTa.
111rbounnt ,npenapaTa 11 Tegenne 6one311u
BoAbHasi no.nyHa.na npenapar VI mco,H#Kau,HH. PhybeKunst nponanoHn-
mcb nHyTpumbnnetmo B 51TORIPIHY10 06JIaCTb, o,rwirpa3 B ,aeHb. Kypc
nWb-
ekuBri ;omen c 20 VIII 1947 r?. no 24 II 1948 r. Ha npormeHrm yroro ne-
pno,u,a Hpemerm 6oAbHan nanytniza 147 mrbexuxii, B KOTOPhIX 6b1.no
no 202 000 e,aHHHu npenapara.
)103bI B OT,ReJlbHbIX IllfbeK1.1,1151X 6b1J111 cze,upou.tne
1-39 If1r1eKg1111?no 200 eAmmg-20 VIII 1947 r.-3 X 1947 r.
40-44 HirbeKuun no 300-500 e,unHHu? 4 N-9 X 1947 r.
Iloc.ne 13 IllrbeK11,11r1 (2600 examu) noc.neonepaunowHmil py6eu, 3axm.n.
Ha mecre onyxann onpe,useastacH BOCTIaJIIITeJlbHbIrl inulmnbrpar.
Ilocze 32 nirbeKunil (6200 awing) 011yX0111) npow,yribmaaacb B BlIfise
noomoro 110,11,B11/KHOr0 Y311a, pa3mepom 1X0,5 CAL, C SICHO HbipamcennbiNi
KonTypom.
floc.ne 44 Hirbexu,ncs onyxoab cra.na onpefiseasubcH B HHAe n.nocKocrHoro
o6pa3onaH1Ist ?Baal:410cl cpopmbi c r.na,n,Kois nosepxHocrbio pa3mepom 1,5X1 CAI.
TaKilm o6pa3om Ha npoTmeHrm 11/2 mecHu,en, B Teller-me KOTOphIX npo-
113B0)1,11.1111Cb nsubeKunn Hpenapara, onyxo.nb, HAsoe ymembuniHwasicH B pa3-
mepe, B CB5I311 C npoH3BeAenHoil 6Honcllecs, BHOBb AocrHr.ita cHoero nepnoHa-
Haabnoro o&bema 1,5X1 CAt. YtIHTbIBa51 3TOT 4aKT,AO3bI 'BB041,11NIOr0 npena-
paTa 6bIAH yne,rameHm:
45 nirbetcunn
45-55
56-64
65-147
? 10 X 1947 r.
? 11-22 X 1947 r
? 23 X-3 XI 1947
4 XI 1947-2411 1948 r.
? 800
no 1000
no 1600-2000
no 2000-5000
rlocAe 64 Hirbe1u,H11 pa3mep onyxo,nH ymenbunhncH ,ao 1X0,8 CAI. BOJIb--
Hag npn6anHaa B Bece 1,25 Ka.
Iloc.ne 76 mrbeKunti pa3mep onyxonn craz paBlIbIM 0,9X0,7 CAI.
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
- 4
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
.10
t.
80 ora.kTnol.: P.% 31311T111.: (HIS \ 11
Howie 93 nfrbentnii (92 800 e/tifinnt)-19 XII 60.nbnoil iipolt3llezieno
onepaTnsnoe y,la.genne nopawennoro ytiacTKa rpyititoil nceze3b1. rim mecT-
Hoil anecTe3neil cAertan annefinbifi pa3pe3 paiinapiro iia onyxoabio tta rpa-
..witennn
15 VIII 47 r.
finoncna
25 VIII 47 r.
29 IX 17 r.
8X 17 r
:3 X! 17 r.
20 XI 47 r
19 XII 17 r? 69CIAT104k-141-13 nocze 93 IIIIICKLIFIrf (92 800 Q.11111111) ?
irepaanKaablian onepa111111
93E/10K B
rloc.p.? 32 inrbentnii (6400 ennInin)
011yN0.1b ymemannaacb, npn na.mna-
Win 011pCJIC:IBIOTC/1 11.10Tlible
pa3mepom 1,0X0,1 CAI
Flocie 43 iIInejuiijI (26 600 minim).
on) xo.gb ,?13e.nittniaacb jj,o ilatiamatOro
pa3mepom 1,5X 1,0 ciz
llocae 64 nirbcKunii (53 700 cantina)
pa.tmep onyxo.m ymenbuinacn
1,0X0,8 can.
floc.le 76 nirbeKunii (77 400 cionnin.) ?
onyxo,11, ymenbrinmaci, nO paamepa
0,9X0,7 cit.
rancatcy
1 cm
M
Ha6nio,lenne no anpeab 1951 roan nona3a.lo oTeyiunne
unAnaa If NtcTacra3os
npuanalion
Pile V. Cxema perpeeenn onyxo.an 6o11bnOil B. B nponecce un-benitifn npenapara
nuti,e eepxHero i timie-HappmHoro ima,parim JleBoii rpy,arroil ?Kane3b1.
yqacTox napeHxumbr nrecTe c onyxo.ribro. Onyxo.nb aa pa3pe3e
maRpocKornitieckn rip0143BOAIIT Bnettaraeuire qm6poallef1ombl.
M0p(POJIOriltieCROB mytiellne 6noncnposaIIHOPO maTepliana 6buro 11p0113-
13eaeuio npocPeccopom SI. J1. Panonoprom, 3ax.rnottemte KoToporo 6buto cze-
Aylow,um. rilcranonitieckom utccaeAosawal, Haps-1,ay c (int-
6poaaeHombr, B itenTpe npenapaTa o6frappkezi y3enoic BeJIHqIIIIOfi c 6y.nasotr-
(1)oro 42 (a, 6). BOJIbIlOrl CD. 7 111.49 r Houle 47 nirbeKunil (43300 eilininui)
mecTe npewiteil onyxonit ? yray6.nenne, n.noula,abio B 0,8 am, r11y6nnoil
B 0,2 CN1 BeCb 3TOT yliacTox 110KplAT nopManblibiM 3111ITC.1111eN1 KypC 31111eK-
npenapaTa 60.11bliblM npepnali
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(Dom 43. Bonbnofi orD 121V49 r Houle 25-AneBnoro nepepuBa B ItirbeKUITHX.
COCTOMIlle onyxoan yxyawlinocb B uenrpe piaci-Ka, rite panee 6maa ony-
X0ab, BHOBb 1IORMIROC6 y1140THeHNC, pa3mepom 0,5X0,8 cm c 1131gBdiellIteNt
B uenrpe
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(!OTO 44 a, 6 Boab!tan
)16:non.enne 12 Kan-
uneeK116 11.narno3. paK
npanoil rpy.anort Kieneni
II craluni, incronornne-
Clilliilarno3 cKnpp.
28.11.50 r
nirbeKunii npenapa-
Ta B nepxne-napyKinom
Knaapairre npanoil rpya-
11011 ii(e.TIC3b1 ? onyxo.lb
(1)116po31rort ILTIOTHOCTII C
libICTynOM n Billie Mina,
pantepom 2,0X 1,5 CM,
WW1 ? XHUjCI3OIf K011-
ClICTC11111111 B npanofi
110,1MbIllIC11110r1 oftacru
pa3mepom
1 0X0,75 Cif, mnrKnil,
11:10Clinct
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
^
(DoTo 45 BO:16113R ,a 21 IV.51 r Flo OKOH11a111111
Kypca Hubei:mai npenapa-ra B npanoil rpyanofi :Ke-
.1C3C iien caea nocae nepaanKaabKoil onepaunn,
nponaneaemion B npouecce Kypca mrbeKunfi, roa.
TGMy naaaa (18 111.50 r ). flimflam! peunanna nail
meTacTaaon OTCyTCTOpOT 30.155 r OCBHJOTC:16-
culoBana Komuccnefi Mmincrepuna aapanooxpane-
nun Comaa 3aKmonenne KOMI1CCIIII >. ila.mHernuee Ha6.7no,aemue Ha npoTsmcemm Tpex
aeT He 06HappKII:10 110HB.leHIIH KaK1IX 6bI TO HI! 6b1.10 1IP113HaKOB peunanma
11.111 meracTa3om. B. omens K.111HtlfleCKIL 3a0P080a. rpyaHme >Ice...Tient co-
xpaneubi. CpoK Ha6.7nonem1H 3 roaa 41b mecmua (cpoTo 52).
Ha6.r11o,EkeHne 16
60.113HaFI M-LI, 46 :len KaimmiecKnif AltarHo3: paK .2e8o17 apyatioa oice-
.7e3b1. r cKupp.
B NtapTe 1947 r. 60.TIbHaH caygarmo o6paTma BHIINIaHIle Ha 011yX0J1b B
N10.104H0fi iiieze3e B sepxHe-HapywHom ee Kmaapare H Ha HeKoTopoe
3TE:KeH1Ie KO>K11 B 3TONI mecTe. OT npeaameHHou onepaunn 6o.m.Ham orKa-
3aaacb n 12 VIII 1947 r. oeipaTmacb B KsiIIHIIKy 6noTepannn.
CHNIBTONIN nopaxceinisi B NIOMeHT nocrynneinisi B 12 VIII 1947 r.
B sepxme-Hapy)KHom KsanpaHTe 7ticeae3br npouzynbmaer-
naoTHam onyxoab paamepor 2X2 Cit. 60.1e3HeHHam, IIHTIIMHO cnammiam
C napeHxnmoff ?Ke:1e3b1 H B newype cnamHHam C KW/1(er'. B :lemon noil.MbIWeq-
HOci BnaU1He OrIpeRe.15110TC1 Tpn alimcpoy3aa, 11.10THOrl KOHCIICTeHI1,1111,
6e315oae3Heinibie, He cnaminime c Ko?Kefi. 0,3.11H 113 MIX paamepom
1.5X1 CL,?Ina ,apyrne--Seantnmoff c ropounmy (4:mTo 53).
25/VIII 1947 r. 6uoncuA ? nccetleHa no:minima onyxo.rm aemoci moaoti-
moil ..,Ke:Te3bi.
rucro.loaugecKAoe ucc.leAosaHne, npon38e,zeHHoe npo4)eccopom 51. a. Pa-
nonoprom, o6HappKnito KapinHy cKuppa C MH01-011I1CaeHHbINIII ytiacTxamn
PY6u0soil Koaaaremmaunn CTpOlibI, HapfLay C e5flIHHqHbIMIIpaKOBbINIII 511:161-
KaNut co:mai-toe? crpoexuR C ,aereHepaunn paKOBbIX K-aerox
((Dor? 54, yilacToK cKimpa).
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
?
;Al
tf
1!
it
82
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
OBPATHOE PA3BIITIIE 33101iA'IECTBEITIl11X 011YX0j1Efl tIEJ1013E1iA 11
IIH'bEK11,1111 TIPEIIAPATA II TEAIEIIIIE BOJIE3H11
Bo.nbHan no.nyna,na nepBbie 71/2 mecllu,eB npenapaT I ii II moan:kin:awn',
a d 16 anpenn 1948 r. io KoHua Ha6.ino,nemill ? npenapaT VI moxicknicau,nii
cyxoci, no.nyneHHblli 113 Ky.nbTyp unmorplinallym, Bbipautennbix Ha 11C1CyCCT-
BelIIIbIX 1111TaTeJIbHbIX cpe,nax. HirbeKutin npon3Boxi.inicb BHyTpliMbiwettao,
B nroxinitylo 06.nacTb, 1 pa3 B ;Len B 11pIEBUIINIbIX HIDKe ,1(o3ax:
1-2 - 25 V111-26 VIII 1947 r.
3-9 -
10-20 -
21-30 -
31-51 -
52-13S-
139-153 -
151-177-
173-:.)85 -
386-439-
27 V111-3 IX ,
4 1X-16 IX
17 271X
29 IX-24 X .
27 X-2 III 1944 r.
3 III-19 111
20 111-16 IV
17 IV-29 XII
30X11 194S. r -5111 1949r.
Ho 200 e;t111iitit
300-S00 ?
-. 1000-2000 ,
200
1000-2000
15U0-3C00
1000-2000 ,
1250-11,00 ,
1000- 30U0 ,
5000 1000f) ,
Bcero 6o.nbliall no.nynima 439 turbemuill npenapirra.
Houle 20 IllfbeKLI,Hil IIHTIMIjIbTpaT B o6.nacTii onyxmii yNIellbL1111:1C51. B
jfeB0f1 flo,i1b1LIJe4HO1I Bna?tome npotuynbiBatoTcll 2 .111mcpoy3.1a macTiittecKon
KoHclicreintun.
Bec 6o.nbHoil 49 ice, 650 e.
Iloc.ne 43 itHbeKunii, 14V 1947 r. B BepxHe-Happi:Hom KBa4pai1re
rpvLHoii;Ke.ne3b1 BimeH py6eu nocze 6noncim. CooTi3eTuBeinto py6uy onpe-
,71,eA51erc11 cli1I6po3Hoe ymoTHeline 6e3 rpallnu, no Hii)KHemy ero
Kpato?MOCKOCTHOil ynacToK, pe3Ko 6o.ne3Hentibifl flPii outynblBaHHH.
Floc.le 51 inybeKunii, 24 X.1947 r. HincaKiix 113meHeHi1h1 no cpaBilaino c
IlpejbI2137111,IINI OCNIOTp0M OTNIeTIITb He paercll, 3a licKaioneHilem 6o.ne3HeH-
Rom, KoTopall ceilnac ormenaenn no xony Beer? py6ua.
Iloc.ne 101 Hirsexumr, 9 I 1948 r. npli oulynbiBaHnii nocaeonepaunoHHo-
ro Volta B cepexiHe ero onpe,ae.nlleTcll 6o.nee nem) oriyxo.nb, pa3mepom B
1,5 c.lt B AnameTpe, moTHall, merKa 6o.ne3HeHHan,
Home 138 in-rbeKunii, 2 III 1948 r. onyxo.ib B Tan= -/Ke.1e3b1 He npo-
wynbiBancll. Yn.noTHemie B o6.naurn py6ua nmeeT xapaKTep py6uoBa TKa-
H11 B ray6nHe jIeB0f1 110,1N1b1111e11110r1 1311B,B,I1HbI?marKa1 oBaabHan anmipaTii-
necKall x:e.ne3a. Ha,u,KmonnnHbie H 110aKJ110111111HbIe npocTpaHCTBa CB060,111-1bI
((poTo 55).
Houle 208 inrbeKunii, 22 V 1948 r. onyxo.rib B o6.nacTH noc.neonepaun-
onHoro py6u,a He npoutyribmaeTcll. CHNIITTONI K81111Ta orpilu,aTeAblibifi. flpIE
outynbiBaHHIT 011pea,easierca pacriabmnaTbni ynacTox, 6011e3HeHHbIri Ha
clitynb, 11.110THOBBT0f1 KOHCIICTeHIIIIII, 11,110X0 KOHTyplIpOBBHHbIll,
B...neBoti nonmbnuenHa Bna,ntille onpeaealleTcll arim(poy3e.1 B ,RnameTpe
0,c am, ILTIOTHOBBTO-3JIBCTIltleCICOrl KOHCIICTeHLI,1111. Bee 56,7 KO.
Opratibt rpy,aHoti K.TieTiut peHTITHOCKOMIlleCKH 6e3 naTanorntiecKux 113-
mei-terral.
Houle 248 turbeicua, 14/VII 1948 r. ony.w.lb a apyaHou Nce.leae He onpe-
itcleTCS. LiaabHeihniiff Kypc InubeKunfi peuieHo ripoBoxim am6v.naTopHo. B0j1b-
flaH 113 crainioHapa BbinlicaHa.
Houle 297 illrbeKuuci, 11.IX.1948 r. B BepxHe-Hapv)KHom KRampawre
BOB rpy,n,Holi )1:e.rie3bi Jhh1HeiiFlbui py6eu, LJiflHOH B 6 Cit. B flO1O-
Billie mocKoulla, ymomeHllbtil ynacToic maim, 6e3 neTKIix rpannu,
Be.nillinHoto 2,5X4 c.41, Tlina ii3oallpoBallitofi ,a0.111 nacenxiimbi ?Ke.nesbi,
Me-
CTMU B 3TON1 ynacTKe oTmenaturcll 6o.-lee mumble iloparmenTbi. BeCb 3TOT
3AKOHOMEPHOCTII JEMTBHH 11.11130T1'HHAHHOF0 HPETIAPATA
83
ytiacToK HmeeT npu3HaKH 43H6po3Hoil macTonaTull. JiiimiPoymbr lill B 110,11-
mb1u1etiao11, lin B ira,nicniontituroil o6.nacTllx He na.nbruippoTcll.
Home 354 illrb'enutil 22.XI 1948 r. B Hmutem or,u,e-ne py6ua OT 6iion-
cliii
? yrIJIoTuIeuIne. Ilpil oulynbulaiillll ripa3aaKoa peulifisuBa onpeditem4Tb
He paucll. B J1eB0I1 110,ELMbHllet1H011 Bnaxine npouvribmaeTcll :Ke.ne3a, Bed-m-
m*1a c neneStinHoe 3epno, noxisBmilall, 6e36ane3HenHa5I. B HaKJIlOtllitulo?
11 110,11,1SJ110111111110c1 o6.nacTllx allmipoymbi He ripouwnbmaiorcll. Bee 55 Ka.
Dome 370 ?HFrbeKl.tHri, 10.XII 1948 r. yn.noTHeHHe B 06.nacTH inimero
puma py6ua 6e3 Hem:camp meala.nbilo OT Replier? Konua
pyou,a npow,ynbiBaeTcll Kpyr.noe o6pa3oBaiine c roaaKoll, poBira noBepxlio-
CTI310, Ha outyrib HanomllHamatee KucTy, pantepom HeCKOJIbK0 Meabine 1 CAI.
B OCTBJ113110M IIHKaKIIX Jl3MeHehuHhi HOANIeTIITb He maeTcn. Bee 55 ice 400 e.
Hoc.ne 385 inrbeKunil ? 29.XII 1948 r. ymoTHeHlle B Hipmem ?wale
pyoua 6e3 3aNleTHbIX Hamelleintit B TOM )Ke nano:Kelm H ice.neaa B HOAMbI-
uietiaoil Meatimbiro OT Bepxuero KoHua py6ua npoulynbiBaeTcll
Hencilo He6o.nbutoe Kpyr.noe o6pa3oBainie, 6e3 tieTKiix rpaHnu.
Houle 390 iiirbeKunii, 5.1.1949 r. ymoTireinie B o6.naull HIPKIlero OT-
AeJia pyoua 6e3 mmeitenuil. )Ke.rie3a B nonmbunenlla BiriaAllHe B TOM )Ke
nano}Keinin. Koirrypm n.noTitoro o6pa3oBaluill, pacno.nmeHnoro meallmblio
OT Bepxiiero Konua py6ua, npoutynbiBatorcll Hellmio. Or npea.nox:einioil
AnKaabitoil onepautni 6mbHall orKa3a.nacb, Ho cor.nacHa Ha HcceneHHe ony-
xo.an n py6ua. Hepapsila.nbllall onepauull 6.1.1949 r.? Hccenemte onyx:Inn
II 110,U,N1bIWeLIIIbIX JIIIM4)0y3j10B. 34flipHbui napKo3. OBBJ1b1IbIM pa3pe3om
oneptieli c?rapbni py6eu. 06Ha:Keirm noKpbmbuoBbie cocyabi. KneTnaTKa
noambunetura Buaxiiibt, andireBpo3 6anbula rpyjiiiofl 1bILL111,11, K.nertiama,
pacnanoweitilan mem:Ay 6cobwoll H mma rpyAnamll mmuniamn II anoneB-
po3om, noKpbmaioutan maayio rpyanylo mutiny BmecTe c ceKTopom rpyaHori
?ke...TIe3b1, B ueirrpe KoToporo pacnanaraeTcll py6eu 11 ymoTileulle, ? Hcce-
nellbt 0,11111INI 6.710KOM. Y3J10BaTbIci 11.10B Ha KO)Ky.
Flpli TIICTOJIOPIPIeCKOM Hccae,ttoBaHtni 110,3,N1bILIMIIHbIX .inimipaTillrecKnx
-,Ke.ne3 npil3HaKoB NieTacTaaa o6Hapyll(elio He 6bi.no. Ha61ioAa.nacb KapTima
xpoHtinecica rimeprma3tur c rHe3,11Hofi npomuDepaunefl KiIeTOK P3C. flpii
rHuanorilltecKom licc.ne,noBaHllit TKaHH ymomellHoro pyoua B WTHOM 113
ynacTKoB obi.na o6trapy)KeHa KapTinia cluippa, B ?npyrom ? KIICTO3HOR
CT011aTHII (4)0TO 56, 57). Ha 'Toppi:emu' noc.ne,nylotunx 8 mecllueB B COCT051-
Hill 6mbHort He 6bIzo o6HappKeHo .KaKitx-au6o tipn3HaKoB onyxaneBoro
npouecca ((Flom 58 a, 6). ?
CIlyCTST 8 mediates-, 6.-IX 1949 r. 6bi.na npori3Be1I.eHa KOHTp0J11311BH pactun-
peHHan 6Honcitn, npll KOTOpOrl 6bIjI IICCegeH crapbdi py6eu.11 KzeTnaTKa no,a-
mbnueltHoil BriaX1HbI. FlpH rHumoriitiecKom mccze?noBaniill pal/immix ytia-
CTKOB TKaireil Ftaxaxax memewroB onyxcioll o6HapyllteHo He 6b1J1o.
Ha npormerunt uocae,ayioutirx J1eT Ha6j110,aeHTIFI y 6mbHoci npuenatcoa
pequauaa u.iiu A(eTacTaaoa o6Hapy21Ceno He 6b1.lo.
30 aBryua 1955 r. CIleHlIa.r1b1Iag KOMIICCHR TIpe3u,nriyma Ynerforo
Go-
BeTa MitHricTepuBa 3.npaBooxpaHeHirn CCCP ocBtrileTanbuBoBana 6o.nb-
Hylo M. n ?ulna c.rie,nyloutee 3amionelille: vipaicriinecKit 3,nopona, peuv.allBa
onyx:mit HeT, NieTac-raabi He onpe,leallionll?. CpoK Ha6JnoAeHll1 -7 8 .neT.
CIpirBeAelliroe Ha6,nrozeinte 1103B0j1ffeT yrBepKnarb, tITO rioa Banniniem
uni3oTpiffiamioro npenapaTa y 6o.nbHoll M. pOCT onyxanll 6bLir IlpHOCTBHOB-
Jlea. PIMeJICH ?t1JIHTeJ1bHb1u1 nepuoa, xoraa onyxo.Tib Kj113111111eCKH Boo6ute He
onpe,ae.iill,nacb. ,TIoKammaturll paKoBoro npouecca conposo)KAa.nacb Becbma
3aMeTHbIM yoytimeHllem patter? COCTOSIHIIH, 60J11311a2 npll6aBma B Bece
7 Ice, ee Tpy2iocnoco6Houb 6bi.na ITOJIHOCTb10 BoccraHomella. CncTemaTllne-
cKoe remaT000rmecKoe Hccire,noBaunte yCTaHOBH.TIO orcyruBne KBKHX-JIH60
IlaT0,11011111eCKIIX 113NleHeHHCI KaK a.nemetrroB ITOB11, TK H xpoBeTBopHbix
6*
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
,
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ti1
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
OBPATIIOE PA3BUTHE 3.101iAtIECTBEWILIX om-xo.TiEn 'IE3OBENA I!
3.-MC0110MEPIIOCTI1 AEBCTB1151 1111130TP11111011101'0 1-11317.11APATA
oprauoB. TaKum o6pa3om. 2.ULre.ThEe su.3.3.opormeu11e 6oabuoil M-u, obizo Ao-
cruruyro aetieunem 111B307pI171.1H::::?il-t 7.? enapa-rom B colieTauun c yika.nennem
nepuutmoro paKoporo y.L. bO11 onepauttu ii pewrreuo-repamtu
(4)010 59).
7622C
remorzooss .
4!1651.2 613650 060 do 1225iSo Dpirrpolurrst
Us. lissesc
_ 284 355 427 439 Jlefisottursi .
P03 .
3031'1100mm . .
Ilaaollsonaepswe .
_0 CermesTsposasswe
Ilimpousrbi
Monouirrbi
coTGOUvab:
Efriornopht-i
30 IX 47 r.
SX 17r.
14 X 47 r.
72 72 71 71 71
4 320 000 4 420 000 4 260 000 4 360 000 4 220 000
0,8 0,8 0,8 0,8 0,8
6 600 8 000 7 000 6 600 7 5110
37 30 39 27 27
6 9 3 2 3
2 1 3 4 1
65 66 66 69 69
29 27 23 29 23
5 4 5 3 4
reMOTZ061111
aplITPOUlabl .
Us isisesc
,TICr1KOWITb1 .
P03 . . .
3ossiroclAumi .
rIamistossepsbie
Cermeirrsposasswe
.TIsimPousTbi . .
Mosouirrhi . . .
18 XI 47 r.
2 XII 47 r
73 73 73 74 71
4 230 000 4 380 000 4 420 000 4 320 000 4 120 000
0 , 8 0,8 0,8 0,8 0,8
8 800 7401) 7081) 7 420 7 000
33 26 22 22 20
4 1 1 3 1
1 2 2 I 2
66 72 69 70 73
25 29 24 21 20
4 2 4 ? 5 4
17 XII 47 r.
31 XII 47 r. 10 148 r
28 I 4S r.
11 1148 r.
.A0 MC1110L114Td ii 1111WPOL1Vabl
30
2p.
; 00f1AMOPEPtI0CICEPtItIE ri.F.AHouv1Tt3i
, - ! . ; ...??_,..r?
:Isry;-.T rit)CifiPb : crIEBPOrn) PIGA . narucT ? tillABPb* -TE1313(1116
V:347r , 14s, ..
Pim VI. ,allarpal\1111a 113MCIIC11Iff KPOlili 60.1131.10A M. 13 ripottecce
ssbesunfl npenapaTa (439 sirbetatsci ? 1228150 earns's)
AliaJ11131,1 xpocif 60ablioil M.
a a T131 I 20 VI1147 r. 23 VI1147 r. 30 VI1147 r.
femor.io611568 69 70
3pii-rpottirrbi 14 100 000 4 120 000 4 200 000
Us. Inuesc . 0,8 0,8 0,8
JlerisousTbx . 6 600 8 000 7 100
P03 . . 15 38 39
3C3111-1011.161 ? 2 1 3
Ilazotisosagpsue . 2 6 5
CermesTsposassue 65 68 70
.1 ststicsurru . . . 28 21 18
MOHOWITIA 3 4 4
remor.no51111 .
3psTpostrrm .
Us. suesc
TIerstoturrbi
P03
3o3s1Io4is.na .
IlanotisosAepsbie
Cermeursposassme
.1111NsI)ouirrbi .
IVIonoturru . .
70 79 71 71 71
4 220 000 4 420 000 4 230 100 4 240 000 4 120 000
0,8 0,8 0,8 0,8 0,8
6 600 6 400 7 200 6800 7 200
26 23 28 13 6
2 2 9 3 3
1 4 4 2 3
73 68 68 69 62
21 25 23 22 27
3 4 3 4 5
2 IX 47 r. 9 IX 47 r.
71 71
4 340 000 4 240 000
0,8 0,8
7 000 9 000
27 29
1 3
4 2
70 69
22 23
3 3
Fettor.no6ss
3PIITPOUIITIA
Lt13. sue=
J1ei1scaurrm
30311110C1)11.11b1 . .
Fla.notscositepSbie .
CermenTsposassue
Thumtiouirrbt . .
MOHOWITb1
25 II 48 r.
5 11148 r.
15 11148 r.
25 111 48 r.
3 IV 48 r.
70 72 72 ' 71
4 180 000 4 200 000 4 340 000 4 360 000
0,8 0,8 0,8 0,8
7 400 6 400 7 400 8 400
11 14 12 18
2 3 8 3
1 1 2 2
' 72 68 65 68
21 25 21 24
4 3 4 3
72
4 260 000
0,8 -
7 200
222
a
68
26
3
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
86
OBPATHOE PA3MITHE 3.110KAtIECTBEIHIbIX OrlYX0.71Eil HEJ1OBEKA H
13 IV 48 r.
23 IV 48 r. I 22 V 48 r.
2 V148 r. IA V148 r.
reNtornoGitu
3puTpouirrb1
LIB iumeht .
.TICii1011,11Th1
POD
Dommodm.ribi
fIanotwosmepnble
CerhtempoBannbie
JIBNIclmturrbi . .
Mom:nun-1)r
71 71 71 72
4 360 000 4 120000 4 100 000 4 400 000
0,S 0,S 0,8 0,8
7 200 7 400 7 200 7 400
91 31 16 14
I 9 1 2
9 3 4 3
71 67 66 66
92 95 22 24
4 3 7 5
70
4 420 000 ?
0,8
7 000
21
1
4
68
23
4
I;1
11
1 VII 48 r.
28 VII 48 r.
II VIII 48 r.
28 VIII 48 r
13 X1 48 r.
remorno6BB ?
3pwrpouuni
: LtB. twaeKc ?
Iferniouorm ?
POE) . .
3o3nBocImabi
rIaaol,Kontepuile
Cei mennipollawibie
jinmcDouirrbi . .
Modowrrbi . .
72
4 300 000
0,8
8 200
31
2
68
26
3
70
4 120 000
0,8
7 400
22
1
2
72
21
4
71
4 ISO 000
0,8
7 GOO
17
2
68
25
4
70
4 420 000
0,8
7 600
31
9
4
69
22
3
70
4 200 000
0,8
7 800
14
2
2
67
25
4
12 XI 48 r.
23 XI 48 r.
2 X1148 r.
13 XI148 r. 123X1I48r.
iemor.n06BB .
70
70
72
72
70
3pirrpounTbi .
4 420 000
4 360 000
4 360 000
4 340 000
4 220 000
Inutelic .
0,8
0,8
0,8
0,8
0,8
JICilliOLUITH ?
6 800
7 200
7 800
8 000
760Q
POE)
16
14
31
37
? 28
30311 Iiocknom
3
4
3
1
2
ri ampucosacpuble
3
2
4
4
3
Cc! meirrnpoBannbre
67
69
68
69
70
.111mcbouirrm
25
27
22
21
? 22
McnounTbi
2
3
3
4
3
10 I 49 r
20 I 49 r.
1
31 I 49 r. 17 II 49 r.
18 11 49 r.
2 III 49 r
rentornoGnu .
69
69
70
70
68
69
apirrpounni
4 000 000
4 200 000
4 080 000
3 900 000
3 600 MO
4 080 000
11,B lumen
0,8
0,8
0,8
0,9
0,9
0,8
JiefiKoUliTbiPOE) . .
7 800
50
7 400
50
8 200
47
12 000
54
8600
44
8 800
30
3o3B1iockBabi
1
1
1
2
1
11a.not1Koymepnb1e .
5
4
5
10
3
6
CermenimpoBaunbio
JIBNI(1)oturrbi
69
22
67
25
69.
19
66
17
69
21
69
20
M01101111Thl .
3
3
6
7
5
4
3AKO110MEP11OCTI1 .aEncTrum mmoTpunAtmoro HITHAPATA
87
Ha6.nlimemte 17
BOJIbHan P-3. KJIHI11111eCKFIcl Amartio3?paic npaeoti apyatioa oiceilant
II cTaauu. FncToJlorliqecicrjji ottaarno3 ? Hauunalocqueic.n paK Tuna C0.1111aH000
Ha (Pone pexco Clotpcocetutott KUCT031-1011 macTonaTuu.
flpu nocTyn.newth B KamulKy 6HoTepanint 7 11tasi 1949 r. ycTaHon.neHo:
BO stlyTpenHeil nom:mime npanoil rpy,twoil >Ke.nent ? y3e.n 5X4,5 CAt, B
npanoil noAmbuuetmort o6.nacm?allmtpoy3e.n pa3mepom 0,75 CAl B AllameTpe.
7 mast 1949 r. Haar IllrbeKII1111 npenapara (4>otro 60 a, 6).
IltrbeKtunt npenapaTa it 'requite 60ne3)Itt
BOJIbIra51 P-3 riptunna ovrinte.nbubtfi Kypc mirrpilmbauelmmx HirbeKuHil?
c 7 man 1949 r. no 11 asrycra 1950 r. B Teqemse 15 mecHuen 6bt.no c,zte.na*-
no 254 11111e1WHII, B KOTOpbIX Bse/teito 63 100 ektmtnu, masubmt o6pa3om
cyxoro npenapaTa moitwillmattnit no.nyttetmoro 113 Ky.nratryp um3oTpHria-
supautemibtx Ha HCKyCCTBelIffbIX nnTaTanbubtx cpeAax. CnycTH 1 He-
?Remo nocze Hatia.na mfbetwHil 14 mast 1949 r. 6buta npoH3BeAeHa 6Hoinctm.
ructro.normecKoe 3aK.rnotteHHe: HatllmwoutHrtcH paK Tuna coznAHoro Ha (1)0-
rue pe3Ko supa:Ketmoil KIICT0311011 MaCT011aTHH. Kypc HirbeKumil He npepm-
BaJ1C51.
4epe3 40 OT Hattaaa Kypca, 17 H101151 1949 r., noc,ne ssedtterm
10 600 e,I0111H11, cermetteno: onyxanb npo,tto.maelt ymenutancH, COCOK cTa.n
6o.nee BbICTy1laTb item paubwe. Eme itepe3 2 Atecsma 17 asryctra 1949 r.
noc.ne sseAeHHH 28 000 eamtmi npit ocmoTpe ycTaHos.neHo: B npana rpm-
noil >Ke.ne3e COOTBeTCTBe11110 py6tty ? IIJIOTHa51 ortyxo.nb 3X4 CAL; cocci( He-
CKOJIbK0 BT5111yT; cnycTa 2 mecinta 14 ORT516pH 1949 r. noc.ne nse,rteitHH
37 000 earn= pa3mep onyxanit cTaa 4X4 CAt B npasoil numbHuelmoil (>6-
..nacTH Jnompoy3e.rt ? 1X0,75 CAt (0:yro 61).
25 HoH6pH 1949 T. 60J1b11011 npoH3nuteHa Hepa,nma.nmaH onepauHR ?
Hccettetwe OnyX0.11I1 B npeae.nax nopmeimmx TKatteil. flaTorticTo.normecKnli
AnartHo3: COJIHZUIbII1 pa K Ha *me macTonaTHH.
B nocimonepatwoHHom nepHoRe H }wee Henpepbumo Ha HipoTH>KeHHH
81/2 mecHues ? ,rto 11 asrycTa 1950 Is. ilp0113B0,IIIIJIHCb sHyTpHmbiaretmble
111113e1(11,1111 npenapatra Toil >Ke mo,awinucawm. Y>Ke cnycTH 1 mecHu mule
onepawtH 21 Rema6pH 1949 r., roma 6o.nbHan no,nytm,na OT Hatta.na xypca
46 000 mmHg npenapaTa, a ,py6eu 6bIJI B xopowemCOCTOnHFIFI, mapy>KH
OT cocKa HOSIBIIJI0C13 yn.noTHetnie B 2 CAI B AnameTpe, i iirrwiecicir ,rwarHo-
cunponalmoe KK macTonaTHH.
CnycTH ew,e OKOJIO 2 mecHites 15 cl>espa.rm 1950 r., Kor,aa 6o.nbuaH no-
mitm.na 51 000 eitmunt npenapaTa ? yttacToK macTonang Hcqe3. Ottaros
yrutoTHemist He oTmetta.nocb. Py6eu, 6b1.n B xopomem
HatIHHan C MPT, B nopa)KeHHorl rpyAHofi we.ne3e HOSIBJIneTCSI yn.noTHe-
1111e pantepom B 1-1,5 cm B xwameTpe. IloKaaH3awm eros? ttenocTontitia:
Talc B mapTe (22.111) OHO oripeAe.nneTcH B o6AacTu cocKa no xoay py6ua,
B Mae (29.V) ? 1130J/I/p08CMHO OT py6Ha, B mane (10.VII) ? noa py6uom.
3TH H3meHeintH nponcxo,acnt Ha (.1>oHe Henpepusaemoro Kylica turbeKuAti: K
22 mapTa 6o.nbitaH HOJIT111.71a, CLII1Tan OT naga.na Kypca ? 53 000 ewtHnu,
K 29 an ? 54 000 eammu, K 10 IllaTIR-60 000 eammu. HaKoneu, 9 anry-
cTa 1950 F., IIPIIHSTB TIOCJIe,IIIII0I0 254-10 HH'beK11,1110, Bcero 63 100
ewiwitt npenapaTa, 6o.nbilast npeKpaTma .netterme, HMen B o6.nacm py6ga
He CrIa5MHbIll C Ko>Keil rIJI0THbIf y3e.n, .pa3mepom B 1,5 CM B AHameTpe 11 B
bpasoil no,wbauetwoil o6.nacTH 11.110T1IbIfl JIHM(.1)0y3eJI (T51>K) pa3mepom
0,75X1,5 CAt, KOTOpbtfi onpenemincH 11 Hmea TaKylo >Ke BJ1HtflTH B (1)espane
Mecsme H 3aTem c HeKoTopmmti Ko.ne6auttHmH B pa3mepax coxparmacH Ha
nporsr>Keinnt utecTHmecHtworo Kypca
4
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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88
011PAT11OE 1'A31311T1IE 3.10K.VIECTBEMIGIX 011YX031:11 '1E:1011EKA 11
CnycTst 71/2 mecnueu no oKonqatunt nirbeKunii, 6oab1tan P. 6blaa
oculmeTeabcnouana 21 anpeaH 1951 r.: py6eu, 6bta 6e3 otiaroa
yrinoTnetilm. Bo3ae pyoua onpengaHacti v3eJloK, pa3mepom 1,25 cm B Ana-
meTpe; B numbunequoil o6aaent TaK)Ke nectionbico yNle11b11111JICH H nme.a
pa3mep 0,75X1,25 cm. Fpy,qHbie xceae3bi coxpaneHm (ipoTo 62).
30 aurycTa 1955 r. P. 6b1aa ocaimeTeaboruouaHa apaqe6Hoil Komnecneil
F1pc3tuuly1a Ygenoro COBeTa MintucTepeTua 3apacooxpanenim CCCP. 1(o-
MIICC1151 yeTaHounaa: dIpauast N10.110t1HaSI )Keaeaa HeCK0.11bK0 Ateimme ae-
BOCI, BO uHyTpeHHem? KuaapaHTe umeeTcH JIHuefiHbIfi py6eu, Oanbal, NISIPK1111,
nuutuKtibtil, 6e360.ne3ltentiblii, onyxonit B )Keae3e iie onpcileofieTest. 3atiaio-
gentle: P.?npaKTimectin mopoua, onyxuan BeT, meTacTa3ou Ile onpeile-
JIFIeTCSI>>.
P. no cneunaabHocTit ?,aupipKep. Bee sTli mum, KpomeineptioAa eTa-
unonapHoro JIetIe111151 (1949 r.), P. ycneamo Bb1110J14151eT CBOIO pa6oTy.
Cpoti imonton,enim 6 aeT 3 mecHua.
Ha6atmettne 18
BoabHan K-u, 42 roAa. Kamingeextifi AnarHo3: peuudusubui paK Aesoa
rpymoil >Kene3bi. IlaTorneToaorimectimi AnarHo3? adenoKapututoma (cKup-
po3Ha5i) c oacTKamu CaltlaK0e0 paKa.
3a 2 roa 4 mecHua o o6patuemm B xaminKy 6noTepamin 6onbtran rt?
0KTH6pe 1945 r. nuaepraacb pan,miaabHoil onepaium no nouon,y palm ae-
Boil rppitat )Kene3b1, rucTo.normectin onpengaettitoro KK ?Ty6y.nopithafi
cmppo3Hbai paK?. CnycTH noaTopa roa,a, B 1947 F. B 06.nacTil noczeonepa-
unotmoro py6na 11051BILTIaCb onyxoab.
B tomen nocTynnemui H tummy 6noTepanini 28 anpeasi 1948 r.
yeTaHoaaeHo: Ha tecTe anal rpyaHoil niene3bi ? onepaunambill py6eu.
Ha ypoatte 4 pe6pa no aesoli napacTepnaabnoil am= ? n.noTHaH onyxoab
B 1,5 CM B nnameTpe. Ha ypoatte 3 pe6pa B o6aacTii ocTaTiia 6oabiuoii
rpyn,Hoil Mb111111,bI ? placToK yILIOTHeHII51. C 28 anpeast 1948 r.
tarbetimin npenapaTa.
liwbetuttni npenapaTa ii Tegenne 6o.ne31111
K. npnimaa B 1948-49 rr. A.TuiTeabmpict, HO HeAocTaTotitto peryasipnart
Kypc nabeKunti: HaminaH c 28 anpeasi 1948 r. B Tetlemie 9. mecHuea, no
25 HtmapH 1949 r., 6oabHofi 6biao caezatio 164 IIH'beKlinn, Hrte,a,eno HiryTpli-
mbauemio 314 000 eninimi npenapaTa, B OCHOBHOM VI moaximKautin. B c.ne-
aymaiem 1949 r. 60J1bHaS1 npininmaaa JI11111b iipaTKoupememtbie Kypebt II
ripitTom C A.1111TeJ1bHb1M11 nepepbmamir
B cpeapaae ? tape . . ? 11 mrbeKunct,
B moue ? mane ? aurvcre
? 40 >>
B ceHTH5pe?HoH6pe . . 18
3aTem B Teqemie 9 tecHues oaabtraH He aetntaacb ii JIHUlb B mime
aarycTa 1950r. efi 6biao caeaaHo 11 ittrbeKunil (c 19.VIII?no 1.IX).
Ha 10 ,ReHb nocze Haqaaa IIHIeK11,11c1, 7 Niasi 1948 r. 6b1.Tha npon3Ben,eHa
5noncim: iicceqe.Ha noaostma onyxwm, paonoameHHat Ha ypotme 4 pe6pa.
naTorlicrozormiecKoe 3aKaiotieHne: paK Tuna adenoKapuunombt (cluippo3-
Mir!) c yttacTKama comithioao pa/ca.
CnyorH Niecsm, OT Hatiaaa .nirbelimul Houle uneeHHH 20 450 eitininu,
ocrasataHcsi OT 6noncmi qacTb onyxwm lictie3aa. KoliTypbt BTO/Oro
yn.noTHetinH Ha yposHe 3-ro pe6pa, cTaan HeHcHBIMH. 4epe3 3 mecHua, nOc-
ae 87 iiirbeKunfl (159 900 minim), KolicTaTnposano 26 ceirrH6pH 1948 r.:
?py6eit B xopoinem COCTOHI11414?.
3AKOHOMEPHOCTH aEnCTBHN 111H3OTPHHAHHOr0 HPEHAPATA
89
B caea,ylow,em mecHue, Koma 6oabiraH nplumaa B 107 HIrbeKII,IIRX
207 000 exiting npenapaTa, B6J114311 py6ua nosmaHeTcH y3eaoK pa3mepom
0,75X0,3 CAL, KoTopbtil Ha npoTH)Ketum caeityloatitx 5 mecHues (Ao ilteupaasi
1949 r.) noqm He 113mettHeTcH; 22 citeHpaaH 1949 ron,a, nocae mecHquoro
nepepbma B nirbeKtumx ero pa3mep pauen 0,75X0,5 c.sr, 3aTem no3)Ke, B
nepnolt, Koma K. ire np0113B0114ITCH mrbeKutni npenapaTa, 3TOT y3eaoK npti-
o6peTaeT ipii6po3ityto 11,110THOCTb H onpextezHeTcH KaK KEJIY,11,011HO-K14WEI11-101-0
TPAKTA
inpoTspKemill OCT, IICTOKLIIIIX nocze ony6anKoHaH11st Tpyita ?BiloTe-
pannH 3.noKanecTae1mbix onyxo.nefi?, Mb! He npeRnplummaau cneuna.nbHoro?
Haynemist 3.110KBABCTBEIIHbIX HoBoo6pa3o13aH11ti mce.ny,rtotnto-Kinuentioro TpaKTa.
npeitcTatoHeT IIHTepec HepHyTbcH .K cy,itb6e Tex 60.TIblibiX, KoTopme ?nu-
cani Hamn B 1946 T.
Ha6.1noitemie 22 (13 1946 r. 113,ameno riojtNe 14)
?BanbfraH 3-Ha, 46 .neT. PaK ntruteuo,a,a. B Komte anpe.rm 1946 r. 6o.nb-
11a51 nonyacTuosa.na 6o.nit npH TJIOTBAHH 11 saitepHcKy ntaux B 06.1acTit
jugularis sterna. Iloc.ne npnema 6o,neyTomouttlx cpeitcru ouvuteHne 60-
Hcne3ago, 110 y 60.11bH0r1 OCTBROC13 aaTpy,a,Heimoe ripoxmae-
nue H aa,flepma flhlILljj B TOli )Ke 06.nacTit.
TIpir pewrreHocKonm4-8 maH 1946 r., rycTaH KoirrpacTHarr macca MC,a-
oefrHo npoxo,aHT no cpuHeil TpeTH nituteHoa. 20.V peaKumn oceaamm
spwrpouuTou 32 Aim B I-1pH Hcc,ne,noBaHHH :Ke,nyadmioro coKa o6napy-
meua Kpoab.
B KJIIIIIIIKy nocTyruna 14 maH 1946 r.
15 mast 1946 r.--natiaTbi Hillemunt npenapaTom 1 moaricliliKauun.
npenapaTa it commute 6oabnoii
RaTa
Hirbeaunn ,U,03a II extinnmax
15 V - 18 V
19 V - 25 V
26 V
27 V
28 V - 30. V
1- 4
5-11 ?
12
13
14-16
no 15
no 20
15
20
no 70
Bcero
,445 eannnui 3a
16 mrbeiamil
20 AIBB -petinexoctcontuz- xmAxasi H rycTaH KoHrpacTHaH macca npo-
X0,a1IT CB060,II,H0 no Hcemy nporsuKeHmo rutateso,na.
30 maH - NtoTaHme cuo6o,m1o. BOJIbIlafi B Hecbma y,a,ou.neTaopHTeab-
nom COCTORH1111. IlepeaeLlefla Ha am6y,naTopHoe .nenemte, lipose,ttem A0110.R-
EItrre1blIbIll KypC- 15 iiltbeK11,Hri npenapaTa no 150 ejtunillu, exceaHeatro.
3AKOHOMEPHOCTII ;117-fICTBI151 1111130TP1111A11110P0 IIPEHAPATA
95
B aHrycTe y 60J1b110C1 110511311,11HCb Cy6leKTH1311bIe outyutemist saTpy,ttneu-
Horo r.noTamtH, B C1351311 C nem B aHrycTe-ceHTH6pe 6bra npoHedttett oToport
Kypc BuyTptimbimenubix HirbeKumil npenapaTa no 500 exit= emitneHno,
B Tegeinie 40 /veil. PenTrenocKdrumecKoe Hccze,noHanne, npoHaBeiteunoe
no oKouttalmn wroporo Kypca, noKasa.no cHo6oitnoe npoxommeinte xouTpa-
CTI1Ori maccm no Hcemy rmw,eHdAy 11 Hopmanbubte KOIITypbI CJI11314CT011
060J104K11.
Bo.nbilast ocTaeTcH noit 11a6.nmemieNt npot1). B. M. CHHTyxmta. B
Tenenlle 2,5 MCC5ILIO13, ncTeKwHx noc.ne OK01111BHIIR aenemist, ee cocTomme
Hno.nne TIOBJEMONITeJ1bH0. BoabHaq npn6amtna B Hece 3 KO. 1-1pHcTynn-
Aa K pa6oTe Tipenos,aaaTeaH, KoTopyro Bella xto cI3oeM 6oze3H11.?.
TlIM OK011tHIJIOCb onHcanne 60J1e31111 3. B 1946 r. C Tex nop 6o.nbila51
3. otTaHanacb no,n, Hpane6Hbim KO1[Tp0J1bHbIM Ha6,nio,ttemtem Ha npoTme-
IMH mem 1947, 1948 11 5-Ti mecHun 1949 rr. lia6,nroo,elme nono.nil.no
yCTBIIOBIITb y.aomeTaopHTe.nbHoe C0CTOY11111e mopoBbst 3. PenTreHanortme-
cKoe Hcc,neaoHantie cHcTemantnecial noKaahumno cuo6o,nnyt0 npoxoxt MOCTb
nituteHo,zita ir.r1 rycTbtx U K11,11,K11X macc 6apHH. IlpoztoabHbie cma,tuut CjI11-
311CTOf1 6bIJIH xopomo ,a,m14epetnutposa1Ibt Ha Hcem npoTynKeHmt. PaHee
HcnuTbmamoe outymemte nenpoxo,tutmocTH nitateno,u,a JUl51 n.noTnbix ramie-
BbIX macc y 6o.nbnoil 6o.nee ire TIOSIBJIHJI0Cb. IlaTonorrinecmix OTKJI0I1e11111:1.
CB513B1111bIX c npexamm 3a6o.neHatmem y 3. ire oTmena.nocb.
AtiaJ1113 K01311
29 X 47 r. 18 XI 47 r. 13 XII 47 r.
6 1 48 r.
remorno6un
3n1ITpOWITIA
JICfiK011,11TbI
303111104111J1b1
Ilanomicuuteptibie
CermenTnponannwe
11111\11:1)011,11Tb1
A1011011,11T1,1
P03
67
3 900 000
7 000
2
2
66
27
4
45
68
3 34000()
6 600
2
2
67
26
3
33
69 68
4 140 000 3 380 000
7 200 7 200
2 1
1 3
70 68
2t 93
3 5
40 30
311 48r
10 11 48 r. I 24 11 4S r
remor.no6nn
3puTpouirrbi
.TIefutounTb1
303111104m:1bl
flanotnionagpnbie
CermenTnponannbie
JImpounTbt
NIOH011,11Tb1
P03
69
4 170 000
7 700
2
9
71
23
2
29
68
3 900 000
6 800
3
1
69
24
3
18
68
3 830 000
6 600
9
2
69
23
4
17
TaKum o6pa3am, Ha6,ino,aemie FIBJL 60,nbHoil 3. nosuommo ycTaHomrrb
110.1101KIITEJ1bHbIrl 443eICT AdICTBI151 npenapaTa Ha 3a6o.neuaHne nnuteuoaa,
KAHHHTteclui TpaKTouanueecH KaK pa K H aaKoHmtameecH BbI3,3,0pOBJleHlIeM.
CpoK Ha6,ino,u,emt5I - Tim roAa.
Ha6.ntoAellite 23
B 1946 r. 6buta Tame Ha.no)Keila EcTOpliSi 60J1e3HIT 6o.nbHoro
Hmemuero KJI4HINBCK1111 AmarHoa paKa npHmoil KIIIIIK11 11 rticTanorunecKH11-
a,u,euomaTo3Horo nomma:
II
111
IL,
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
96
OBPATHOE PA3BIITHE 3:101 11ECTBEIIIIIAX OHYX0J1E11 11E1013E1(4 II
c20 anpean 1946 r. y 6o,nbnoro cra,na circTemamecKH 1105IB:151TbCil
npii Aeci)eicaumi KpoBb, HepeaKo 6br.n11 KpoBoTet1em151 H 6e3 cry.na. B nep-
BbIX turcoax maH, KaK npan.no, cTa.1111 HOHBASITbCH npii Aecpeimultu cHaqa.na
IipOBb, 3HTCM
11p11 peKTocKonini, npon3Beilen1Ioil HerbrpexKpaTilo ? 17 V, 3aTeM
19 V. 25 V ir 28 V 1946 r., OTHM111B0 1311AHa onyxo.ilb pa3mepom 2,5X1,5
CIIXILLIBH Ha unipoKom ocHoBaHHH Ha paCCTOSIBIIII 13 au oT anyca. IloBepx-
Hocrb onyxoall Hepona51, me.inc0-6yrpncTa51, B ueHTpe ee He6o.ribume 113"b5.13B-
Aelme. Ilo oKpywrocTu onyxarin, Ha HOpNIEIJIbH0r1 CjI11311CTOil 060J1OHICC, ne-
CROabK0 memix 6yropKoB, HOKPbITbIX. HOPMailb11011 CJI11311CTOil. 3a1motiemie
Hanyma (ITO. B. M. CBSITyX1111, Bpati MIIpoJlol3a, npo(k. Minru, BpaH
Bafluep): pag tip:Luoti
30 V 1946 r. HatiaTbi npenapaTa ?KID?.
npenapara ii COCTOBIIIIC Linyxonn
Jana
30 V-1 VI
Ihrbexunn LIo3a
I-n-3-n no 20
1.VI 1946 r. peKTocKon1151; KamHa Ta )Ke, liTO II 28 V.
lipoaamellue inmeKunil:
.Litara
2 VI ?3 VI
4 VI ? 6 VI
7 VI-8 VI
,LIo3a
no 30
no 50
no 75
Bcero 420 eaniiiin
8 MOHR. ,L(ecpeKaunsi 6e36coe3Henua. IcpuBb He BbmensieTc51.
PeKTOC1OM151. PeKTOC1011 11P0X0,LIIIT Ha 13 CAI cBo6o,a,Ho. 3aTem, npeoilo-
oeBas1 npensiTcme, npoxoAHT ilaabwe. 51313a, 6bmwasi B ueurpe onyxanH,
noaHocTbio 3awnaa. Ha ee mecTe HmeeTcH Bbm511411BaHHe c paxianbrio pac-
noHaraiouvimucH pyouamn; IIOITbITKa IIPOH3BeCTII IIOBTOpyI0 611011CM? He
)uaeTcH. IJeaocTb onyxo.rui npH 3TOM Hapywena, nominocb He6onburoe
KpoBoretiemie.
8 ?18 'WWI 1946 r. (11-19-m nirbeiumn) no 75 eunimu. Bcero
BBeaelio 1295 eammu.
18 MOHR. He3HatulTeabHa51 6om B 3a,ztHem ,npoxo,qe npi AeckeKaulni.
19 VI-20 VI 1946 r. (20-21-H HirbeKumi) no 75 exliniu. 90 VI?
Goal! npeKpaTnaHcb.
21 VI;-- 25 VI (22-26-51 mrbeKunil) no 75 eiummu. Bcero BBeaeHo
2 810 eximiu.
25 moun 1946 r. npon3Be,aeHa peKTocKoniul. PewrocKon npoxouHT CBO-
O01!0 Ha paccTomme 20-25 c.lt. Ha mem npoTH)KeHHH C.11H3HCTOfi H3meHe-
unii He o6HappKeHo. Ha ypoBtre 13-14 cis, B TOM mecTe, rue pal-lee 6brHa
onyxo.lb, BuBeH cBexcHil py6eu, noxpbrrbiti CBeKIIM 3nirre.rniem
(3aK.-HoHeluie KoHcHaHyma: npocl)eccop B. M. CBSITYX1411, Bpatm Bailuep II
MupolloBa).
26 VI-29 VI 1946 r. (27-30-51 lurbeKutnI) no 75 eikHHHu. Bcero 13,13eae-
1-10 3 110 ei),Hmill.
29 III0H51. 3nwcpu3.
PErPECCI45I AHIN0CAPKOMb1 KO/KH TEJIA
,n,eficTnne uni3oTpunantioro npenapaTa I 11 11 mofiJulniKaunn 6bifio 113y-
Hello B oTuoulenuu aurHocapKombi rpynnoii ynClIbIX B r. 1KneHe-npo(1).
npoci). a-pom H. 0. PurlieuKo 11 A-pom Ky-
C mo6e3uoro pa3pewelum awropoH arnx uccaefi,oHauuri, uurnpyem
ucTopmo 6o.ne3un, rfig 113.10)KenbI CHNIHTOMbi 3a6ofieHamm B MONCIIT IlOCTy-
nstemin 6oribuoro B K.IIIIII1Ky, ero commute nepe,a, naHaaom nirbeKunii npe-
napaTa, 113NieHeHl1n B npouece mrbeKuuli, rucToaoruilecKue ,aammte ii, na-
Koueu? COCT0511111C no oKonitanun Kypca mrbeKuuct.
Ha6nioAemte 24
Bo.% Ic-H, 58 -let PIcTopini 60JIe3H11 ,N9. 400. 110CTyn11.1 B OHKofio-
rutiecKylo KAHunKy KneHcKoro penTreuo-pafimo-oHK000rmecKoro uucTuryTa
7 InOlin 1947 r. Bbi6b1.1 10 oKTROpH 1947 r. IcannimecKuil Auartttxt -
wiettocapKama KON11 re.za.
IlaTorucToaorutlecKnii ,anarHo3- arteztocapKoma (Kano3H?).
Cony-rev:3y!mime 3a6o-aesaHnH-3m4m3ema .ierKux, mnoKapfimoaucTpo-
gmH, apTepuocKaepo3.
BuoncuH - 4 II10,1151 1947 r.. 6noncus - 31 warm 1947 r.
Hagan() it pa3Birrite Hacrosiutero 3a6onettaatisi
B cpespa.le 1947 r. 3a1eTH.1 nosumetute TeNum-6arpoHoro mrrua Beau-
LuiHort B ropounmy Ha Koxte cpe,uHeii V3 npaaoro mega. B anpeze mecHue
-ramie ?ice nima n0aBlialieb Ha npaHort ywHoil paKoHnHe, B mae
ieciue-
Ha anort yumori paKomme, Ha KoH:e B pa3.rummx yHacTKax: Tana - Ha
Horax u >Kneure. IIHTua He &mean, nuoraa OecnoKomoHcrno mc?Ketina
II 3y,R; rurrHa B ,paamepax lie yneanzumasnich, Ho Ha6yxa.a1I, Bbic-rynaH.Ha no-
HepxHocTu KOM:11, 11 ,I1O5lBAHJIIICb HOBbIe.
Status praesens no COCTORHI110 Ha 20 1110HH 1947 r. Ha Kowe cpe,uHert1/a
npaHoro naetia no Hapy)KHoil .nosepxHoc-rn pacnoamKeHo .nsrrHO 2,5)0.8 CAI;
Ha npaHoil ywHoft .paKoHuHe MITHo 0,7 CAI. Ha -leaoll luxe-AO 14 nsiTeH
pa3mepom B 0,8X0,5 Cit. Ha CnIIHKO Hoca 4 TaKnx ?ice rurrHa; Ha Ko-/Ke o6o1ix
6efi,ep Ao 8 meaKux mrreH. Ha ro.lome nozoaoro Haeua 2 calmaioutnxcH
nsiTHa 2X0,7 cit. B 06.9acTn THepuoro Heft, 3eHa H ueceu umeeTcH HecKoJib-
KO MITCH, cripana HNieeTCA BbinyK.lan onyxofib, pa3mepom 0,4X0,7.
Ilofi, npaaoil ii ;lead' KmoHnu,eil-mesaKue nHTHa 0,3).0,3 CAL. Clem OT
nynKa Ha Ko?Ke XUIBOTa oHaabHoe nsano 0,8X2 CAI. Bce TIiTHa TemHo6arpo-
Horo uHeTa C aenuLHbIM, Han TeMHO-KOpiinHeBbIN OTTMIKOM, 6e36o-le3He11Hb1,
He 3yfi1uuue, He me.ayulauwecH, ite moKHylune. 11pH HaaamanHamin oHn nc-
tle3aloT, HeCKo.1bK0 flPHflOLLHiTbl Ii BbICTynalOT Hall. nosepxHocTbio 3,aopo-
Hofi KoH:H.
BO:113110ft nuKHuHecKoro Te.Toc.ao?KeHHH, xopowero 111ITHWL Ka-amble, B11-
nmbie C.111311thIe 110KpOBbI (BHe IISITen II kpame KO)K11 auu,a) illicTme, 'Ho)-
MaIlbHoci 0KpacKH H B.TIMKHOCTII. PerII0HapHme aumcpaTimecK.He -,Ke.ae3b1
OTK.110HeHlIn OT HOpMbI He npeacTammoT. KOCTHO-MballenHan cucTema pa3B11Ta
CHAINIeTpIP4H0-HOpManbH0. POCT 164 CAI, Bee 67,5 Ke. B xermix npoc.nywn-
Declassified
3AKOHOMEPHOCTH JEtICTB1151 Hin3OTPnnA11110r0 nPEnAPATA
99
Haercs semyfisipme Abtxamie c iKeCTKHM OTTCHKON, 0611.MIC cyxHx xpn-
11013. nepKyropuo-Hcnbal 3nyK. Cep,aue: T011bl r.aymie, aKuenT nepHoro Talla
na aopTe, fieHaH rpanHua cepAua-no Ana cpes,mmo-K.rnotuitmoil .1113111111.
Ily.nbc: 92 y/Lapa B :\nnlyTy, puTmwien, MIrKuhi. OTmetiaeTcs cmepo3HpoHa-
Mile neplukemplecKux COCya0B 1..1,11aH0TINHOCTb U 0,1137TJ10BaTOCTb Anna. He-
Oo.abwaH 011b1WKa. 13ap114o3uoe pacwupenne Bell o6enx rofieuefi.
iKlrnoT oxpyr.noil (Popmbi, cfierKa B321yT. II11KIIHi Kpail neemi onpe-
,aefigeTCH rip!! 1'ay6oKoil nafibnamix Ha 6 CAL invite pe6epHoro KpaH, row-
!mai, 6e36ofie3nenubiti, cm,a,yeT 3a ,U,bIXaTeJIblIbINfli
Bepxmiii ee Kpaii onpefie.aHercn no 5 pe6py. Ceze3enKa-Hepx-
HHil Kpail no,rt Kynomm Anaci)parmbi, numathil npowynbumeTcH Ha 16 cm HH:{
pe6epHoro KpaH, caerKa 60.1e3HeHHblif. Otae.abi :Ke-ny,a,otmo-Kuwetmoro
TPKT Ii motleno.noaan cucTema 6e3 3aNlentbIX naTo.aormecmix OTK.TIO-
Heftnii.
JI etieume:c 17 111011f1 1947 r. Hallamr utrbexunu npenapaTa n Hue
exma,Heanbix i3IiVTHMbflflt1Hb1X BBeAeHIfil (B MbIW11,13I strum"). Hatuman c
1 cAt3 Ao3bi nocTeneuHo yHefintumaaHcb Ha 5-10-15 cm3. HHorfi,a no Tex-
inmecKlim npHtuntam nnefi,enne 6biao Heperyfisipuo c HurepHanamH 13 2-3
JmsI ii 6o.abuie. MaKcHmafibuaH ,ao3a ofinoKpamoro nae,ReHHH, no.nytienuan
6o-abHbINI, cocTa13351.aa 140 c,u3-1400 eanH1111,. Bcero 6o.abHoff no.nytnta -
67 mrbeKunfi - 5500 cm3 - 56 800 efi,HHuu 3a 105 AHeil.
Bi3e,aeHHe npenapaTa nepeHocH.Tocb 60.tIbHbINI Hno.Tme mosfieTaopH-
TejibH0. KpONle pe3K0ri 60.1e3HellHOCTH BO HpemH nefietum B mecTe
1lliKaKI1X Cy6-beKTHBHbIX :Kazoo OT 6ofibHoro Ile nocTynafio. ,LI,03b1 6o-
:ice 00 c3/3 BBOAll.filfeb B 2 11J111 3 pa3.-m4umix yHacrKa Team. TutaTefibuo H3-
mep5iembie nyAbc, ablxamie U TemnepaTypa 3a me HpemH Ha6Ju0emiH Da-
To.nornHecKmx crrKfioneHuil He npeAcTaansau.
B o6w,em COCT02111111 6a1131101'0 :HONCHO OTAIelliTb cfieaDouthe H3mene-
3aIllieb B licToplm 6osie3m1 OT 11 1110.151 n 13 MOM 1947 r. yKa3binaer
Ha yfisonzeTHopirreabnoe o6w,ee commie, ymeHbulemie pa3mepo3 netleHH-
BbICTrlaeT H3-T10,1 pe6epHoro KpaH TaribK0 Ha nosrropa nazbua, a TaK>Ke
ce.ne3eHKH - HbrcrynaeT TO.TIbK0 Ha 6-7 CM H3-TIQa pe6epHoro KpaH. Hc4e3aa
011yTJI0BaTOCTb .11111a, ormetiaeTcH no6.aefi,HeHHe TISITeH Ha Kme >KIIBOTa ii
cnHHKe Hoca. Bec 6o.abHoro 68 Ke 400 e. Ha 21 1110.1sp-- 6oabHoff nanytum
1500 eamnru npenapaTa.
B ,aa.nbHeftwem cocroHHHe 6o-abHoro yzytnuaeTcH, HOSIBJIHeTCH 6o,apoe CO-
Hp116arameTcH Hee (K KOHLly aeHernm nec 60J1bHOTO - 70 Ke 500 0).
HTlIa 110CTeneHHO TepHIOT IIHTeHOHBHOCTb oKpacKH, COIIHOCTb, CTaHOWITCH 60-
3anaiaaloT B uerrrpe u B uempe )Ke ripHoopeTafoT BH.Il. Hopmafib-
horr KONCH. PaHbWe II 6brcapee Hc4e3alor 6aaee 1103,11,HO nosu3HawHecH TIFITHa,
aoabuie nem OCTMOTCH 1151THa B 06.TfaCTH oesoll ywHoil npuo6pe-
TaH K KoHuy AeneHHH BHA KOWII TemHoro 3arapa.
3a HpemH fieHeHHH 6o.abnomy pery.nHpHo npoHno,amucb auanH3m mo-
HH H xposH, onpeaefisificH OIl (npo6a c meTimeHoHoil CHHI310), peurreHo.no-
rwrecior lice:le:tom:1mb aerKire *11 cepuu,e. MowHo oTmeTurb nonnueHne 0,11.
HanpHmep, 25/VI 1947 r. 0,11- 18, 2/VIII 0,a -18, 15/IX 0,a-27 ii
15/X - 24. Co CT0p0Hb1 KapTI1Hbi KpotH4 11 motui 3aMeTHbIX Kone6aHHI1/2
y.10B111-b He yfiaeTcH.
7*
in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
ii
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
100
OnPATHOE PA31111THE 3.710K.VIECTI1E11111dX OHYX0.71E0 IlEa0BEHA ii
remora 061111
91)IITIMILII
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P0-3
30311110(1)11.1bl
97 VI
1-;
2 VIII
23 VIII
12 IX
27 IX
14 X
72
74
68
70
62
66
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4 830 000
4 420 000
4 WO 000
4 300 000
4 noo OCO
4 800 000
5200
5500
3800
5200
2800
6400
6200
4
4
10
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6
9
8
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260 300
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,ELanubie naTorucTanorwiecKoro 11CC:IeJOBall1151 (uwrilpyem aaH.inouenne
naTanoro-anaToma npock. 1.11BeaHoaoil-Pawe);
1. Onyxorn) Hou;11 (no aetieHnsi 4/VII 1947 r.).
Onyxonb EOM comm. 113 nputiyunnao nepen.neTaloiunxcH Kaniumnpnbix
cocyuoa, o6pa3yloanix painntmoro paamepa yae.nKll, pe3Ho arrpannuennbic
oappKamateil mann. COCyabI onyxanu npeacTaa.runoT TOIIKOCTel1I1bIe
Tpy6En, BbICTJIaIIHbre anaoTe.nnambnumn anemeHTaNin. oTalitial0111.11NIIICH no-
mimopcjillamom cpopm. HapHuy CO CBeTJIbIMII 11y3b1pbK0B11)111b1M1I Sutpamn
acTpetialarcH wpyrmbie ninepxpomHbie Hupa C 3a0CTpe4111b1M11 woHu,amn,
okppKeHubie aulluockimbnoil 11p0T011.11a3N10ii. B IleKOTOpb1X yuacmax cTpyu-
Typa aiwnombr TepHeTcH, npanwkepupylouthe 3.71eN1elITb1 onyxonn o6pa3ylor
nyum, cocTosnune 113 TeCHO npu.nerawnunx KJIeTOK C aTIMIltHIbIMII, Hmnon-
nsnownmn ace Tam) x.neTicu Hupamu-yuacTith xapawTepa capHombr. Onyxo.nb
pacno.naraeTcH nenocpeucTuelmo no anwre.nuem, B 11e111paAbHOM yuacTwe
IICT01111e1THOC1'b /JO 1 C.11051 KJ1eTOK. 'CJI0i1 B 3TOM yuacTice 6o-
raT 3.nemewra1n aocna.nuTeabHoil innimabrpaului. r.11bI6K11 6yporo rim-mewl-a
pacnoaaraioTcH cHo6oxio B crpome nape.aua urrTpaReir.THanHpno B ariemen-
Tax BOCITaJIIITeJ1bH0r0 HOHJIbTpaTa. RHarnoa: aactiocapKoma (Kanon?).
2. lloc.ne .neuelum, 31/V11 1947 r. B TKaun, memennoil anuaepmnca
nonocKort cocouxoaoro CJIo, pacnonaraloTcH Anixl)yario-paccemmbie, mecra-
M11 co6panubte B rpynnbi COCy,abI. CTelIK11 11X TWOCBeTbI BbICT-
J1aHbI yrulOtaeT1HbIM 3Huore.imem. Cocyubt mecTamn KaaepHomo pacumpe-
Hb), B 60.11bWHHCTBe >Ice npeucTaansnoTcH criaaunimmi. B owe pa3aHTHH
cocy.aoa 11a6.1noa,arorcH CKOITJleI11151 aleMelITOB JIHmcimairoro Tuna 11 npo-
44epannH 6oraT0ft ckn6po6.nacTamn BOJIOKHHCT011. TKaIII1, oKpy)KwouKeil B
Biwa lupin' otambnue cocy,ancTme BeT0LIKI1. Plapolica KapTima nomoro
aameuKeHm COCyf_IIICTOr0 y3eJIKa py611,013011 TKaHb10, cpeun woTopoii pacno-
aararoTcH ocTaTK11 aTpocimpoaamibix cocyuou, oicppkeriume r.nbioxamn re-
mocHaepuna.
14cc.ne,aoaaHlle y3e.TIKOB onyxonn, B351TbIX nocze .netienrui, 061rappKii.qo
Filllet11451 o6paTiroro pammui onyxonn (atirliONTaT03IIbIX paapacTannii)
ii
peaxo abipmeHHyro peaHnswo meaeHxnmEt. 11Iowrop Iflue,awoaa.
OcmoTp 6OJIburoro me pea ro 31 10/X 1948 r. BoJrbljoji B xopo-
!nem COCTOHF11111. 3a roa HIplem He 6one.n, He noTepHa a Hece.
7.:
3A1011OMEP11OCTH AEHCT131111 1111130TPHHAHHOF0 HPEHAPATA
101
Flonmennenuabix runeH 11.nn Bo3o6noa.nemie pocTa npeacimx ne oTMeqaeT-
c. Tpyuocnoco6en, pa6oraer. Flwrua liCt1e3.1111 compmenno
TOJIbK0 ua JIeBOfi yuniort paHounne 01111 C Tpy,aom pa3MMIIIMbl 14 11MelOT BHA
KOJKII lona TeNnioro 3araRa. Bpau Kyrnma.
Ha cpoTorpacininx (pile. 70, 71, 72, 73) npriBo,turrcsi BHA 6o.Tworo .no
11 noc.ne .rieuenun.
Tawilm o6pa3om, B maTeplimax 11CCJIC1h.0Balillil MO/KHO HarITH OTBeT na
pHo, uonpocoa:
1. flopmenne anruocapwomaroanoro xapawrepa nouaeprzocb o6paTno-
my pa3IIIITHI0 foil BJ1H1I1HCM nwbeHunil umaoTpnnalmoro npenapaTa nepuoil
11 aTopoil mouncluiwauuti.
2. Perpeccufi 6bina 110JII1011, tITO BbIpa31IJI0Cb B OTCyTCTBIIII peanunaa
na npormenun noc.neapoukero cpoKa na6.nioaeingi B Temenne roaa, B TO
Bpemsi Haw uo nauana IllTheK11,13c1 onyxonb uomma Hecbma 31Iat111TeJ113110ii
cTenenn pacnpocTpanemm.
3. PerpeccHH onyxorni conpoamuaaacb namenetmem rucTo.normecmoro
ee cTpoemis.
4. HaKoneu, c.neuyeT nougepKurb, tITO 3a6aneaanne anrnocapHomoil
y 6anbnoro K. OTHOCHJI0Cb K HaTeropHH Hecbma TH)KeJ1b1X 3a6onesaimil H B
uannom c.nyuae npnmeHenne uniaorpunannoro npenapaTa npnae.no 6o.nbHoro
K HC110 abipaxcennomy mninumecHomy BbI311,0pOBJ1e111110.
11
PErPECCHS1 11PE,I1,PAKOBbIX 110PA)KEH1411
Ha6amemie 25
BonwraH C., 40 :ler. K.111HuHecHuil unarHo3: aaeuo0u6poAta JIeB0.i rpyu-
noil ?we.neabl. Hamizo Kamponoao apot(ecca. FucTo.nornuecruni umarHoa:
aoeHorptI6poita.
Cursinrombi nopaweium o momewr nocrynnemig B K.qmittxy 24 MOHB 1947 r.
AeBail rpyunaH :Ke.ne3a pacnonmena necKommo BbILUC npauoil. Flpn
ocmoTpe, B ueuTpe cc, nau COCKOM-3ameTHoe na ria a Ha6yxamie. flpn
ouvribiaannu B aepxle-anyTpeHHem HHaupanTe ?we.neabi onpeuezHeTcH ony-
XO.T1b naoTiroil KOHCHCTCH141411, pa3mepom 2,7X2,5 cm, c Hepoanoil 6yrpn?
cToil noaepx.nocTmo, nenpaanabnort oaa.nbnoil (Popmu, 6e36one3neunaH.
KonTypbt--treTicne 3a nclunoueHnem aepxne-napy)KHoro orue.na, rue onyxonb
Kaic 61,1 nepexo,awr B napenxiimy mce.neabt. rIOA COCKOM-no.nyaymiaff cma.a-
Ha-naunHalouteecH aTmenne coma. CHMI1TONI KeHura-no.no)Kwreablibifi.
OkanococicosaH apeo.na B Hepxneil no.nowine ampa:KeHa xopowo, B HmicHeii
BTHIlyTa B cmauky. 143 cocica-abtae.nenne m0mun0-6e.noro num
(puc. 74 a, 6).
B 110,EIMbIllIetIHOil ana,anHe npouvribmwoTcH uaa .numcl)oya.na,
naoTnoil KOHCHCTCHHHH, nepabdi-paamepom B unameTpe 1 cm, BTO-
poil-p,5 CAI.
llpaaaH monoturaH )1(e.ne3a OTICTIOHeHlIrl OT HOpMbI He npe,acTarameT.
6 aarycTa 1947 r. 60J1bH0r1 nponaaeueHa npo6HaH 6t/oncusz, u.nsi 'hero
ncceuena ouHa aTopaH gam, onyxonn.
? Bo apemH onepaunn ycTaHoa.neHo, 0113/X0J1b, pacno.naralomaHcH B
T0,11114e,-/Ke.ne3bi, Ha 6onbinom mem ,npurspKeHmi HCHO orrpaHmeHa OT oupy-
>Kammer! riapeHxumbr, B 0,11110M }He yuacTwe, B aepxlie-HapyucHom caoem
HaaupaHTe, oHa IIflTUALHO clicama c napettxu.moti, KK 6bt apacTaH B Twiny
:Kumar:A.
-t
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
102
01;PAT110E P.X31111TIIE 3.1oK.kitEcniEni1ux 011VX0.11E11 111.:.11011EKA 11
,a.nn rticTo.normecKoro IICC.11e,a0Ba111151 B351Ta no.nosittla onyxo.nn, 51C110
orepatittitetaiast OT ompy?Katouteil napenxiimbi, pactto.naratomancn co m-01)0111,1
11p0T1180120.110.710-1011 TOrl, KoTopan spacTaer B napettxnmy /Ke.le3b1.
fncTo.nornEtecKoe ticcae,aoaattne, nponne/tentioe npotpeccopoNt B. T. Ta.
aa.naenbni, I103B0.1111J10 cite.naTb 3atunottenne cdie,aytoutero xapawrepa:
1104nt6poma.,- npitgem B OTiteJlblIbIX iKe.r1e311CMIX paapacTannnx I1MelOTC51
npnmaKtt npeapaKoaoro xapaKTepa)?.
TOT >ice 6noncnposannbal NlaTepitaa 6but no.aseprurr ncc.nedlonannto
npo(Peccopo'm 51. JI. PanonopTom, KoTopbal npinue.n K aamniogemno, tITO y
60J1bH0fi C. minipocKonntlectut HNleeTC51 TO.11bK0 KapTima adttenotim6pombt.
B031\10)11O, t1TO pacxo>uenne mmay ic.rninntiecKnm11 rncTo.norntiecithl.
alar11o3om canaano c Tem, ElT0,11,7151 6110FICHI1 6b1:1 B351T itanmettee THflhItUlblfi
cpparmenT 011yX0J111, B TOil ee macTn, KoTopan npeAcTaamnacb OT ompy)Kato-
wen napenxtimbi oTrpanntiennoil SCHO, B TO spemn KK Haii6ozee Titnntinbtil
yttacToK, KK 3T0 513CTByeT 113 npitse.aennoro moue IIPOTOKalla onepaumn,
pacncoaraacn c npnmo npoTllsono.nomort cTopotibt.
C 7 aarycTa 1947 r. 6(111bl-toil trattant inrbetwint npenapaTa wropoil mo-
,a4nKatunt.
IhrbeKum, npenapara ii TC4CIBIC 60.11C3IBI
flpenapaT BBO.:111J1C51 BIlyTpl1MbIWetI110, B 51r0,3,11t111)110 o6.71acTb, o.a.utt pa3
,aeHb. Bcero tibuto c.ae.nano 57 nErbentnii, B KoTopux obt.no BBeil,e110
96 000 mum.
,E103b1 B OT,ReJlbHbIX turbeKunfix 6bunt c.le,apouine:
1/Ini,eKunn
Aare
3.03a
2
3
4
5
6-11
12-20
21-57
7 VIII 1917 r.
8 VIII 1917 r.
9 VIII 1917 r
10 VIII 1917 r.
12 VIII 1917 r.
13-20 VIII 1917 r
21--30 VIII 1917 r
1 IX --13 X 1917 r
50
100
200
400
SCO
no 1000
no 1500-2000
no 2000
Home 20 mileminil iraMecTe 6b1sweil 6nonctin B o6aacTit onepaull0H-
noro py5u,a nwintobTpaT pienbmnacn, KOHTypIDI onyxatut cIaJIM HetleTKIIM11.
30 asrvcTa 1947 r. 6o.uxan suruicana 113 KJIIIHIIK11. 21-57 111-rbeKU.1111
lip0113B021.11.T111Cb am6y.naTopno.
Route 32 ntubeKtual nitcptia.bTpar B o6stacrn onepauttonnoro py6aa
eine ymettbunmcn, ita NiecTe 6bistuert onyxo.nit cTa.Tto npowynbisaTbcn yn-
zontettne, nanomnnatoutee rio csoefl KoncncTetatun ao.nbKy )Ke.ne3m. B
jie-
BOil noambnnetnioil ana,u1ie-2 .nnwpoyana 3.1acTntiecRoil xonclicTenunH,
6e36o.ne3neunbie
flocze 44 nErbeKunfi 111-14/IlabTPaT B o6.1acTit nocaeoneRattnonnoro py6-
ua 6o.flee tie npoutynbtaaeTcst. Onyxam ire onpee.rineTcn. B neroii no,timbl-
wennort nna,anne unn AnNupoyae.n a.nacTnimort KoucncTenunn, 1 CM B Ana-
meTpe.
Home 57 mrbeKunil onyxo.nb B JleBofi rpy,a110i1 ?Ke.neae ne npoutynbr-
saercn. ,11mapanmecKne y3.7th1?TmKe.
Ifirbeidinn npeKpatuenbt. BO.T1blia51 ocTamena nofi, 1ra6..inuennem.
unttecKnil ocmoTp, nowropnembill citcTeNtaTmecKit Ira npoTst)Kentur 1 ro,u,a
11
7 mecnues, IICTeK11151X noc.ne oKonnannn .neilennn, T. e. C OKT516p51 1947 r.
TIO asrycr 1949 r.?ne o6trappK11a Katulx-Jui6o OTIC3011e1Illil OT nopmbi: pa-
3AKOH0MEP11OCTI-1 .11E11CTB1151 1111130TPIII1A11110r0 BPERAPATA
103
nee 6b1aman onyxoab ire onpeJte.rineTcn, peructuapubte .nitmcpaTntlectute
.11e3131 ne npoutyribmatoTcn.
remomo6nn
3pirrpounTbi
UB. 11111INKC .
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3o3nn0tPiLabi .
fla.noin120h11.101f01311,1 ?sassodadauo oastrumirEed Eins9 1M1191f09
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11L/cli11 S11/11.011: 021c1d@d0L4 a `1JHTIMMJIH 141111U11110110 ou urnmaw B.L3AuD
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111:E011311 0nnauat3011 J 1Jo11s1f09 A 1,11111)10111111 a330nodu a `w0E13d90
61761 u-L3S-Ige OZ 61.0100
?sant'ariad 410)1EHEIld11 ausialloto IfEEEMOLI
'esz, 'Dad) ?olsaext uollEod9a(1) luvemiairm, 1101E.109 `uorolfow aa Baum
? (9oRiLv
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somunEadu xnasis E09 nwollars uoadisinrausu daimedex 1113011 01E al111e1DEd
-EU(' 11011c003 X1c1113011a0061 IJOHTIncL1111 llOITIqIfO9 H I101cOd10
-11111111T11.1 01E109 3 ButisindEsd 01qs0wzo303 B3t0issawAdea90 Xe101130d11
X1c113IIMII'0NC U 111M.3OW *sotrox xnnilEatraw JAdmos Ham uonalraimarga
-03 HNUIIIUItialit- 11111911h01alfI101%1Adll plITIK11.91:11(1)11H 110Mc111'09311 11 IVOE0d
-01rm3 OD 1111111110131IIV 11011E01311N slaudum saawAduago arsadaistv manes
-oda311o119 2? :311110h011in? OWTIOISran oiler icaLdououed .0 ?is riodopnal)
?odu woiniarasEllodu `131111EflOrDlf3311 OJON3ahli.101:01311J 31E1AUSE3d
.icalnissoEsd90 W1911E013101 3 31331?1
113 g X g Kodamed 1qCdraOIC tronolida v000du lawnniadou griwahaadn 0201-1
-1;7113V71 Bansdauo saaramodu 110ast-09 Bdusals gi IfHllNOcLHH 101 a-3ou
?111:E3I1D11 'W3 ePoXen If iXg`i domed aarnsami
'1113s1.-90 poilhamrnsrou uossdu s Baaarnsiwaraduo aalled nirEScatwill
II VW11101:311 1.1311OX.f110 Xr111113I113311VMOVE 31111111EV,I 30111N:4'10
901
9-?000800061.001?1701.0-1.8dC11-V10 ZI./170/? eseejej Joj panaiddv Ado ? PezWeS u! Pe!Pssepaa
108
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
06PATHOE PA3MITIIE 3a0IWIECTBEHIMIX otlyxoaEn T:1011LKAit
CIIMIITOMM 6oHe3nn npu nocrynnennit n Hammy 4 11tapra 1948 r.
Ha Bepxneii noBepxnocTn 513b1Ka, no cpexteil JIHHHH?ynacToK nopme-
111151 pantepomMI1t1Oli B 1,5 CAl, uiiipniroii B Bepxneff Tpem 0,5 au, B M-
I I I iX A,ByX Tpemx-1 au, I 1e1Ipa1311.11b1 10 OBaJIbII0i1 (kopmm, 6e.noro uBeTa, me-
poxoBaTbni npu outyribmannn, yr.ny6.neH Ira 0,1-0,2 all, OT,LteJICH OT Hop-
ma.nbnoii CAI131 1 AgMapKa111 101 I I 10fi Minna Kpacuoro uBeTa, =pima B
0,1 CAL JIHNupaTHnecKne ?Ke.ne3bt He npoutynbulaioTcn (pnc. 79).
11 MapTa 6onbuoii npon3Be2i.ena 6llonenn, )1.1n Imre. Hecenena nanomna
nopmenHoro ytiacTKa.
rucTo.norntlecKoe nce.neaoBaHne d6Hapy)KH.no aTHnHnecKne pa3pacTa-
ititci 3nnTemin c yTomuelluem ero 11 HBAel I II HMI I napaRepaTo3a.
C 12 mapTa 6o.nb1toil nanaT Kypc HirbeKuHil npenapaTa.
Ihrbentunt npenapara n Tetienne 6one31111
11p0I13BO1LI1J111Cb BityTpilmbiwenno, 01U111 pa3 B eyTKH, npena-
paTaNt BTopoti moancinniatum. 0D,03bI npenapaTa 6bi.nn c.ne,nyknume:
Hubei:mu! .g.ara
1? 5.51 12 111-20 111
6-10-H 22-26 III
11-20-H 27 111 ?12 IV
no3a
200-600 eannnu
600-1000
1000-2000 3.
iloc.ne 20 11/1"beK1111fi, 16 800 extHnu npenapaTa, aeruconzaKutiecKoe no-
pax:elute neneino. Ha ero mecTe oOpa3oBaacH ynacToK, noKpbrrbiti nopma.nb-
HbIN1 311IITeAllem.
floc.neapoulee Ha6moaenne no3Bomuto yeTanoBuTb Ha npoTB:Kennu
14 mecnues yAomneTBopmeabnoe cocTosmue ombHoil.
CnycTn 14 meesu,eB BlIOBb na noBepxnocTu 513bIKa 11051BHACH 3rHaCTOK
oefiKon.naKun. floBTopHbifi Kypc infbeKuHil ,nperrapaTa cHoBa npuBe.n K nc-
14e3HoBeHmo ero, noe.ie nem y 6o.nbHoil KoncTampoBaHo Bbi3,n,opomellne.
Tatum o6pa3om, JIeIlKonJraKncr I3bIKa y 6o.nbHoft 0., 110CHB111a51 .lJ1fl-
TeJlbiihIfi it vnopnbiit xapaKTep, He noaaaBai3tuancn B03J1eriCTB1110 06b11I1 10
npnmensiembix Aene6nb1x teponpitsiTuri, no BAI 1 51 11 I leM IlirbeKUlifi tun30Tpn-
naHHoro npenapaTa Hcne3.na (pm. 80).
HTaK, MU Bnae.nu, 14TO HapB,ny C THEM HI IbIMII 3.9oKanecTBeHnbimH HOBO-
o6pa3onannnmn, ono.norntlecKnm npenapaTom yaaeTen Bb13BaTb npontecc o6-
paTHoro pa3MITI151 B pa3.71 I 111HbIX nopa)KeHnstx, npnpo,aa KOTOpbIX B HaCT051-
Inge Bpemn npu3HaeTcn npeApaKoBoil.
BO3M0>KHO, 14TO TaKa51 KBaJIM4IIKaL11 151 naTo.noruneeKoro npouecca 6y-
aeT cymeeTBoBaTb TOJIbK0 AO Tex nap, noKa ire orKpoeTcB ncTintnan npluni-
na paKa. Hoo Tepmint ?npupaKoBoe coeTonHue? Ira ypoBne immix coBpe-
meHHbtx 3naHnil He couepKwr Hmero Hnoro, Kpome nena.nbuoro o6eutamm,
trio TaKoil 6o.nbHail mo)KeT B110C.HeCTBIIII neperrm B KaTeropmo nopmen-
liblX 3A0KalleCTBeHHIDIM npoueccom.
AllaZI 13 KJIIIHIIIIKKIIX Ha6.rno,ReHnii, liponne,Refunix B npouecce 6noTe-
pannu 3T1 IX 3a6ckneBaHHfi, uaer HexoTopbal maTepna.n ,non cyKaelnin no BO-
npocy o naToreHe3e, KK 3TI1X 3a6o.neBaHHfi, TK u o naTorelle3e paKoBoro
npouecca. Bo3HuKaeT Bonpoc, He 51BA1IOTC5 III 410A06HOTO pOaa COCT051111151
ye nattanbnoti craatteei paKo8ozo npouecca? OcHoBaHHem K TaKoft nocTa-
HOBKe Bonpoca HBASHOTCH ezeitylouthe (paKTbi:
IOCTI1 A,Et1CTI1 I 1 51 III 1 130TPIIIIAIIIIOTO FIPEFIAPATA
109
1. Dm nopmeHnn npeTepneBaioT TOT dice tzpotiecc 06par/tow pcmttrun
no,u, B1111511111eM Tex )1(e MI1KpO6HbIX 4)aKT0p0B, .xoTopme BbI3b1BaIOT o6paTHoe
pa3BuTne paKoBoil onyxann.
2. Mexammm o6paTHoro pa3BHTHB qnpe.npaKoBoro? nopmeHHB TOT :H4e,
1 ITO II mexaHH3m pa3pyluemis paKoBoro nopmeHnst.
3. rHeTanormecKoe ucc.neAoBaHHe paKoBoil onyxchnH 'Ha pairumbtx 3Ta-
nax ee o6paTHoro pa31311THH, BbI3BaHHOTO MHKp0611b1M cl)aKTopom, noKa3mBaeT,
EITO B npouecce perpeccun moryT BO3H11KaTb II BO3H1 1KaIOT COCT051H11 51, nicTo-
aorntlecKu HeOT.//11/UAlb/e OT Tex, KoTopme maccucknullpyloTcn KK COCTOciIIH 51
KaT 3J1eMeHT0B, npumbim o6pa3om
yKa3bmatounix Ha ero 3.7toKenecTBeHHy10 npnpoAy. He 3acTaem A 14 Mb1 3T11
.-temeHTbt pKe Toraa, Kor,aa 3a6o.neBaHHe npotuno CTa2UII0 nepBoHanaabnoro
.4)opmnpoBanut 11 nepetu.no B c.neapountfl 31'an mopcpo.nornnecKH BbipmeH-
Horo 110paiKeHII51? BOT Han6anee oTBeTCTBeFrHbii Bonpoc BO BCeil npo6.neme
aKTHBHoro aeneinin palm. He ecTb All ?npeapaKoBoe? nopmeme Ta eTaalln
paKa, B KOTOpOfi TepanewnineeKoe BO311efICTBlle 51 13.1151eTCH HaH6o.nee 3(14ex-
THBHbINI? lie 8 3T0ei All cTaatut pan nau6onee aocrynen 6ttorepanectruite-
(w3vy 8030eticr8wo?
DTH B011p0Cb1 B0311 1 IKalOT He OT 6e3Haae3KH0CTII npmteHeHHB 6HoTepa-
TIM! B nocae,nylotunx eTa.nnsix paKoBoro npouecca. HeT. FlpHmelleHne aKTI1B-
novo Ae1ICH1151, KaK Mb! BII11CJIIJ, 344eKTIIBHO fl B COCTOHHIII1 pa3BliT0r0 paKo-
noro nopa)KeHHB H B COC1051H11 I ,naaeKo 3auleauero npouecca. Ho nocTanoa-
Ka Bonpoca o caoe8pentelutocru zetteHtm eCTb 3aKoHHoe Tpe6oBakme 344eK-
TUBHOCTII. OH I 1Cal1HbIe lIa6JIiOgHHHcI HBAHIOTCH 061eKTI1314bINI ocHoBaHnem K
TaKOil TIOCTaHOBKe Bonpoca, TaK KK 01111 110Ka3bIBaIOT, 14TO He Bee, a TOAbK0
HeKOTOpb/e a,aell/XPII6p0M, HeKOTOpb/e C.11yHaII AeilK011AaKIFII HyBCTBH-
TeAbHb1 K 130T1)1111aHlIONly npenapaTy. C.ne,noBaTeabHo, KaTeropun TK Ha-
3bumembix ?npe,npaKoBbix? 3a6o.neBaHHil He oJHopo,ana aa'iKe B rpynne mop-
cpoaortinecKit oLtHoTtumbix nopaxieHnit.
3m KC Ha6,11011eHII51 3aCTaBASHOT 3a,nymarbcB Ha.q naToreHe3om paxo-
nor? nopa)KeHmn B acneKTe ero CB513 I I C ?npeapaKoBbim? COCTOHITHeM. MMeH-
110 3T0 eocTonHne 600ee gem Bee Apyrne c y6eanTenbHoeTbio roBopuT 0 TOM,
14-10 opraHn3m tie.noBeKa Be.ieT aKTI161-1y10 6opb6y C EIMKTOpaMH 3.noKatiecT-
BenHoro pocTa, 6opb6y. He npeonanen KoTopylc, paxoBoe 3a6o..neBaHHe He
no.nynnT esoero Aa.nbxertmero pa3BIIT1151. He noTomy AH TOAbK0 ilaCTb npea-
PaKOBbIX COCTORHIIii Bnoc.neucTBHH .1aeT KapTHHy paKoBoro.nopa?KeHHH? Ec-
.111 CTaTb Ha 3TII 11031 1 LIU II. TO 311.4eKTI1BHOCTb aene.iHn paKa 3Ha1411TeJ1b110
no3pacTeT. PI 310 6\TaeT He npoifitinaicTtuza paKa, a repanuR paKa, H npitTom
ceoeopeitennaft.
BPEMEHHASI PErPECC145I 14 IIPOBJIEMA
PEOPAKTEPHOCTI4
HapB,n,y c Ha6.7noaeHnsumH, rae KaintepoallTunecKan peaKtunn, BbI3BaH-
Ilan 1111 130TpIlliallHbIM npenapaTom, npuBoxvia K CTOilK0f1 perpeccun onyxo-
.7111 C AiIIITe.11bHbIM KAIIHIIHeCKIINI 344eKTOM, B pue czynaes Ha6510fi,a11C51
14111b BpemeHHER 3c1)cpeKT, BCJIe,a 3a KOTOpbIM HacTyna.na 4)a3a pappaKTep-
HoeTH. BBeflemie npenapaTa 6anee He 131313b1BaJ10 KaHuepaintnneeKoff peax-
6o.ne3Hb BHOBb npiiHnma.ma npemee TeneHne, nopaweHHe nporpeccH-
poBa.no ii 60AbH0fi nepexo,nn.n B xaTeropllio He noansaiounixcH 6uoTepane-BTH-
mecKomy zetieinno. B HexoTopbtx caynasix npn BBegeHHH unt3oTpllnaHHoro
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
-
110
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
OTWATHOE PA3BIITIIE 3a0K.VIECTBEI1111,1X 011S'XINIEft 11E.:1011EKA 11
npenapara 6brao xoHcrarapoaano orcyrcrane Kaluteparniratiecmil peaxuna
y>xe c Hatia.Tia ,xypca, XOT5I nopmetme no caoemy r1IcroreHe3y, SIOKa.1113a111111
II .ripyrum ripimaxam 51B./151.TIOCb IIJILCHTIItIHbIM C Tema, .xoropbte Ha 1111130-
TpIIrlaHHbIfi npenapar 3axonomepHo pearapotiami perpeccaeii. 0;111axo no-
Ao6Hbie czylian 6b1.'ni OTHOCIITeab110 pe,3,1(11.
B Hacroinuert roxie Mbl onacbmaem pamoro poAa nposamenaH peippax-
repHoil peamula B rpynne rex 6o.riblibix, 3.11oxaliecrael1ibie ,nopmenan KOTO-
pbtx OTHOCII.THICb K xareropau 7-1YBCTBIITe.T1bHbIX K iniciorpanaHHoNiy (pax-ropy_
Ha6.navtenne 28
BalbHam 11-o, 52 ro,],a. IcanHatiecKaii xiarno3: petfuaua pasa noc.ie?
paxilia.maofi onepaulal JIeBoll rpy,a,Hoci )xediemi. 1-HcTozoriftiecKnil AllarHo3:
crpetfuaue paKoaoeo 3a6ale8atuz5l) (,aaBbUOBCKIIII H. B.), trry6yAspHo-me_le-
3ucrasi cpopma paNax. (npocp. Taaazaea B. T.).
B InoHe 1945 F. B OHK0.10r1i4eCKONI IIHCTI1TyTe 60413H0r1 Fl. &ma 'won-
seuetia amnyraung rpy,3,Hori )xe.me3bi no noaaay paxa. ,Llso ipeapa.rifi
Atecsma npoBoxiocH xypc npockmaxrattecKoil peHrrenorepanna. B Aexa6pe
1945 T. 6b1.1 3amelieH He6oabuioli BHyTplIKO>KHbIrf y3e.n, Ha paccrosnina
4 au OT onepauiloaaoro py6ua. lb o coaery zeHautero Bpatra 6bLno cae.natio
7 ceaHcoa peHrreHorepanan no meraay Maae. nocze 7-ro ceaHca B o6oacin
onepaunoHHoro pyOua II B HeKOTOpOM PaCCTOgH1111 OT Hero 11051BILIOCb 6o:Ib-
moe 11.710THI3IX BHYTplIKO)KHbIX ymoa. 3arem 60J11311a51
ewe 13 ceaHcoa peHrreHorepanna ii 3arem zetleinle 6b1.no 3axolitieHo.
25 1110H5I 1946 r. 11. 6biaa nomeuieHa B 60.11,511111,y B xparnie T51>KeJIOM
COCT051H1111 no nomay meracra3oB paxa.
B CB5131I C xapawrepom moxatiecraeHHoro nopa)xeinui II xupyprattecxoe
.rieqei-nte ii aytieBaH repannsi, COC.T1y/KIIB CB010 C.TIpKoy, aa.nee 0rKa3a.Turi: no-
aropHaH onepaium 6biaa pe Hetio3mmidia, a .nyHeaaH Tepannn npaae.na K
06111I1pHbINI otiaram Ii BbICb117a11110 HOBbIX paxoabix y3JI0B. KO>Ka rpyAnoci
Kamm Ha mecre paHee yAmeHHoil rpyAHoft :Keze3bi 11 B cocumix yttacrxax
6braa ycesnia MHOiKeCTBOM paKOBbIX y3.710B, copox BOCeMb 113 MIX nauxia-
.111Cb CtleTy, OCTa.HblibIe )Ke He Ntomit 6bITb COI1TeHbI. llopmemasi xmica 61,,i--
.1a mum? cnasnia c no,aaexcaulaNni TKHHHNIII, 113'bH3B.11eHa B o6.nacra py6ua,
?Tema, 6arpolio-caHeri oxpacio. PeraoHapHhill t1.1.110THb111 .ninuparaliecxact
6b1.1 ma.no nousiDxeli. B0.11blia51 110.71HOCTb10 norepma rpy14ocnoco6Hbcrb,
rpe6oaa.na nocresmord pexmma II B 3TOM COCTOHNIIII 6u.na craulioHapoaaHa.
C momeirra rocnirrammaium 6o.abHast FI. ocramoacb naa. Ha6manginiem
21/2 roiLa. B regeHlie KOTOpbIX .The411.11aCb 1111130Tp1111a1IHbIM ripenaparom.
Ilepsmit Kypc mrbeKtudi H Tettexite 6o.rie3mi
Ilepabdi xypc IIH1eKUJIIi npalo:Dica.ricH 6 MeC5111,eB C 25 1110H51 110
25 Aeica6psi 1946 r. FipenapaT BB011.71CH iiHyrpambiwelnio 0,1111I pa3 B
B reqeHne neptioro mecHua 6bIzo cileaaHo 12 iiii-bexuaii (1 800 eILII-
111111,), B retieHne c.neaylounix 5 mecHues-1 00 111rbeKIIII171 (40400 mama).
Cae,3oBareabHo, FI. npHHHMaaa 11WbeKU1 Junnb C OTHOCHTe.11bHOlf peryafip-
HOCTWO: Ha ripoTspicemul nepHoro wecramecsitnioro xypca 68 xiefi 6anbnaH
ocraaaaacb 6e3 zetieHitH.
B npouecce IficbeKL11111 6b1.11I KOHCTaTIIp0BaHb1 Cile,ay10111.Ile 51BJ1e111151.
1. 1-1aCTb 11.10T11bIX KaHKp0311bIX 3.10B HCI1e3J1a; ocraablibie MHbUlliJ1HCb B
pa3mepe, cHeaa.rmcb 6alee naociiamil H M1K1fMH. 213.1ei-ran perpeccaa 6ioni
noaraepx:AeHbi rlicroaorintecim (crp. 160). 2. llepHoAintecica, noc.rie Brie-
aeului 110KOTOpb1X cepu ii npenapara, ormeqaaccb noabiweinie Temaeparypm
to 38-39-40', COTWOBO)K,E1aBILIeriC51 03H060M, r0;10BHbINIII 60JIHNIII,
3AKOHOMEPHOCTII ,IEHCTB1151 1 111130TP.1111A111101.0 TIPEI1APATA
111
C13OM $36uteil pa36arocra, pe3xam- ocaa6aelluem. 3. 4epe3 Hecliauxo Hacoa
Houle airbenuni y 60.1b110i1 1105113.11 HACH 1111TelICIIBI1b1i1 3ydl1 B o6aacra onepa-
anoHnoro py6ita a xampo3aux ymoa, Ha6yxaime H noxpacHeHHe Hx. 4. Bec
60JIbIlO1I yBe.IIIIIIIIACH Ha 41/2 Ke. KpOBb: P03 -31 AtAtIttac a Hatia.ne am6y-
xaropHoro AeLielnifi, 21 AtAlittaC-25 XII 1946 r. Femorno6H11:28.V111-55%,
25 XII-60%, 3pmpouxTbi: 28 VIII-3 920 000, 25 XII-4 660 000.
C 25 XII B .,TIetle111111 6o.abuoil ohm cHe.naH nepepho Ao 31( Hitaapst
1947 r. Bo apemg nepepuria y 6OJIbHOft aacryna.no yxy)unemie: HOSIB11.110Cb
IfeCK0.11bK0 110BbIX y3e.TIKOB, xa1Ixpo31{asi npapoaa KOTOpbIX 6bIfIa noaTHepHHe-
Iiil racro.loripiecxn. 60.111,110171 6but natiar import xypc inrbexuail npenapara.
Bropoil Kypc imbeKtutii if -revenue 6one3mt
Bropoil Hype 6bia Hagar 31 Sittaapn 1947 r., npiniem ;103b1 6buni yae-
initienbi OT 1 AO 3 TbICHII exaniu. 11p0H3B0,1111./111Cb mexiemio,
xpome npa3xnitnibix
Tax )K K1( H paHee, y 60.IIbH011 Hepexm nocze Ha Hecxo.ribxo
nacoa noabnuaaacb remneparypa ,Lio 37,5-38-39?C, alior,ga c o311o6ama.
llocne nexoropbtx HWbCKLLIIM, B mecre nopaxcenini, B pyOue 11051B.T1 51.11HCb 3y1L,
:K.:Keane II 60J1e311e11110CTb.
CrlyCT51 2 NleC5111,a OT Hatiaaa wroporo Kypca tiacrb y3e.r1Kos crane 6o.Tiee
IIJIOCKOil, Hacrb actie3aa, Hacrb 3amerHo ymenbwmacb B pa3mepe H claim
mHrtie. HapHily C 3TliM 11051BH.111Cb liOBbIe y3e.TIKH, xoropble B noc.neuylouniii
IlepHOA TO 11Cile3H.1111, TO 11051BJI 51.111Cb B110Bb.
C 10 aripensi AO3bI &Inn yrie.nageHbi Ao 2000-4000 ei1HHI1. Ha IllfbeK-
unto. Cnycrsi 4 mecHua or Hatiaza aroporo xypca, 'coma 60J1bHa1 npiiHma
131 rarbexualo, 196 860 eximiti, ripa ocmorpe 4 111011H 1947 r. ycraHoa..leHo:
Ha acem ytiacrKe, HatuutaR or 4 pe6pa u ebuue, Kama AuzetcaR, noaeuxuaR.
Bce 6btaulue 3aecb glabt uciieanu 110.4HOCTWO. Y3ezox, pacaarimeinibalno
nepuHeil alica.vuipHoct mania, Tenepb c rpy,kom npoulynbniaercsi. Tpii
HI-1X y3.ria 6e3 113Atenexua, tieraepruil HIDKHHi1y3ez car 60.1Iee II.TIOCKHM. ,T111M-
(1)0Y3T1b1 B HaAK.T11014 11111-1bIX H 110,aMbILLIegHbIX o6.macrsix He na.nbnapporcsi.
B c.neAylouule 7 HHeil 60.711311HH narlytia.na no 3000 eximiu, ex(cAHeriao.
Llepe3 8 Ana, 12 HIOHH npa ocmorpe KolicraraporiaHo Aa.abHeihnee yn.10-
H ymeHburemie y3e.nxoa.
CnycTH 5 mecHuea or Hagan? HToporo Kypca, KorAa 6bLuo c,/te.naHo
155 I1lfbeK11.11171, Baegeno 245 800 ycraHomeHo: Ha aceAt ytcacr-
Ke AC8011 110.1106111ibt apyaHoii K.ReTKU u ebuue y3A06 He onpeaeARerag. Ha
mecTe 6b1aw11x pal-tee Y3.710B ripil BHHMaTe.1IbHOM ocmorRe IMONSHO yaimerb ene
3amerHym mirmeHratuno. Tpu y3e.111CCI BHH3Y- 6e3 3aMeTtiblX u3AteHenuti.
ilamtkoyiribi Hare He onpeotie.asnorcH. PeHrreHocxonim rpy,tuiori KJIeTKI1 ITO-
xa3aaa OTCyTCTBIle narozormiemix 9J1eMeHTOB B AericHx H cepaue. B0,11bHa51
npH6a1311.1a B Bece 3 ice.
B relief-me 1110.1151 a aarycr- a 6aubliaH nartyciaaa no 2000 eaamiu me-
AIIBBII0, !Tome IlpH3AH1111 11bIX Cocroimile ocraBazocb 6e3 nepemeH.
14 aarycra 1947 r. KOHCTaTilp0BaHO: Ha 8cem ytiacrice 8bUlie 4 pe6pa
/coma noaeuxcHaR, .MR210.51. Ho noaAlbuuetiHort y3eAku 6e3 nepeAten.
J11111111)oy.abI Hlfr,u,e He onpe,RezHIOTCA.
CIIyCT51 mecsiu, 10 ceHrH6p51, ripii ocmorpe 6aribHoil ycraHolizeHo yxya-
uieFaie - o6pa3oBaHne HOW:11X y3BAK0B no rpy,aHoil H .HeBOrl 110AMbIllletIlla
.111-11IH11. CnycrH elite 20 RHeil, B o6aacrti pyoua 11051BILIHCb HOBbIe rpyrribi
onyxo.Tietibix y3e.nxoti B 0,1-0,3 CAI B xiamerpe KaKabIff. K 3T0My apememi
(29 IX 1947 r.) 6aabHail npaHma or Hatla.na Broporo xypca 223
anbeK-
- 375 600
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
OBI'ATHOE PA3BIITHE 330KMIEC1'BEIIIIIIX 011YX0.1Ell 11E:10BEKA ii
Haniman c 3Toro momenTa, 6one3llb cm,na nporpecciipoBaTb. CTanii
11051B:ISITbCH BCC noBbie 11 noBme Bbichinaiinn y3enKoB.
Yxy,uweinie 6one31111 natianocb B npouecce lIIrbeKLuIfi, KoTopue npon3-
130,1[11JUICb, iai II pane, BilyTpumbunetnio, meameBird, c neKoTopumii npony-
cimiii, HO lie 6onee AnnTe.nbubrmii, nem npemyte. Tai, n aBrycTe 613I.110 npo-
nvutelio 7 Ana, B cenT5i6pe - 6, B oKm6pe - 5, B lio5I6pe - 8.
nine 111113eK11,11H ocTaBaniich 6e3pe3y.IBTaTubnin. Boni:man >Kim ew,e rod% Co-
cTonime ee nocTeneuiro yxya,wanocb. B nermix o6pa3oBancn meTacTa3.
ft norn6na B ,U,exa6pe 1948 r., nepe3 2'/2 roaa nocne Toro, KaK nanana
die-
Lieltile uni3oTpimatmum npenapaTom.
B na6nioaemin ira2t 6o.nbnoil FI. 6bino ycTalionneno cnea,yioatee:
1. Perpeccnn 3.noxatiecTBeintoro noBoo6pa3oBalinn, BbI313BIIIIB5i 111MCK-
LHISINIII npenapaTa, 'lacuna apeAtennbui xapaKTep. Ho 113 48 y3noB npn 3TONI
iicne3no 43. Ilorneonepaunomiblii py6eu, ii oiTppKaioutue ero mann, panee
11JIOTHb1 II cnammbie, }la 311atIlITe.11bHONI npocTpancTBe CTa.1111 Nisinumn ii
110.11311)1(11b1M ii. FlicTonornnecKoe 113ynemie otiaroB perpeccim nousemuno
KniututiecKylo icapTinly o6pamoro pa3BIITIISI (CM. tiacTb V).
Perpecciin iime.na mecTo npn 6e31Ia1exutom, intaxypa6nnbnom COCTO1IIIII1
11 61)1.na cpaBlinTenbilo ,rinnTenbitoil. Qua npoaonmcanacb 14 AiecnueB H 6131.na
CTOJ1b 311aLIIITeJlbHOCI, tITO 6onbitan Bepilynacb K >K113H11: ona
Bbunicanacb 113 KJI111111E11. Ee pa6oTocnocTionocTb 110:1110CTb10 BOCCTB110B11-
.nacb. Bec yBeniitni.ncB Ha 4 Ke. remorno6iiii Bo3poc Ao 70% BmecTo npenc-
mix 55%. 1(nnunnecKnil ocmoTp, penTrenonornnecKoe iiccneasoBanne ue o6-
irapyndiBanii nopa)Temin iiyipeiiunx opra11013.
2. Ilpoitecc o6paTnoro pa3BITTmi paKoBoii onyxonn y 6onbnoil FT. 6131.11
IICK.11101111Te.11b1I0 06ycnoBnen Bsea,ennem mii3oTplinannoro npenapaTa. 3Ta
06YC.1101VICHTIOCTb Bbipa311nacb B TOM, 11TO 11epil0a B nepBom Kypce
conposoncnancn perpecciieli, nepepus B IllrbeK111151X - pOCTOM HOBbIX paKo-
BbIX YVIOB, nepliou 1IwbeKuHf BT0p01.0 Kypca - 13110Bb perpeccileil.
Becb npouecc o6paTitoro pannTnn onyxonii, natinioaaBunificn y FI.,
aaeT nonnoe ocnoBanne oTnecm 3noKanecTBennoe nopaiKenne 60:111)11011 K
KaTeropini IlyBCTBHTe.rIb1IbIX K uni3oTpiininnioN'y auTn6nacT0mnomy TpaKTopy.
A ecnn 3T0 TaK, TO npeKpautenne perpeccnii B npouecce inneKunii, 6e3pe-
3y.11bTaTIIOCTb itanbnertwero nplimeitemin npenapaTa 3acTaB.115110T cilenaTb Bbl-
BOA 0 TOM, IITO COCTORMIe tlyBCTBIfTenblIOCTH CiMeHILTIGCb COCTOHIIIIeM pecli-
paKTepliocm. nopoasimunie TaKyio cmeny, OCT310TCH
Bonpoc AO:DlieH HATII o 311anemin KattecTsa npenapaTa, o peaKumi onyxo-
nesmx KneToK, o COCTOHHIIII oprainT3ma. flpenute nem neperim K paccmoTpe-
mno 3TI1X BOTIPOCOB, OCTBHOBIINICH iia neKoTopbix upyrux na6.inoueininx, rag
nposmannacb peciipaKTepnan peaKunn.
Ha6aloAemisi 29 ii 30
BOJIbliaii C., 51 r0a. KnimintecKnil a1Iarno3: patc npaaort Atodiotthort oice-
Aeabt II cTannti. DicTonornnecithri:-Ateracra3 aaenoicapntmombt (mg 6110-
DCIIII B31T, ?AIM .7111MC)0y3e,T1 113 TIOAMbIllle11110c1 BIlait1111b1).
Becitoil 1946 r. 60J1bHaH cnytiailito o6napymdina B npaBoil rpyunoil
:Te3e ynnomeune. Benutnnroii c ropowniiy, noaBil)Knoe, 6e36one3neituoe. B
Teneinie cne,ayknunx asyx mecsweB onyxo.nb yBenintiinacb npli6n1131ITenb1-Io
BaBoe. CnycTsi elite 2 mecnua, B 'none 1946 r. 6onbiran o6napync1ina TaKylo
'Ate 0113rX0J1b B npaBoct B CB1311 C 3THNI ()Ha o6pa-
TI1JIaCb B LlefiTpanbitbul onKonorntlecKnii 11HCTIITYT, rite 6131./1 nocTaBnen
2Lnamil3 patca it npeanmena onepaugn, OT KoTopori (ma oma3anacb.
rIpn rIOCTVflJIeHmI B Kv111HHKY AAR nenemin uni3oTpitnamtbni npenapa-
TOM, 1 aBrycTa 1946 r., npn ocmoTpe ycTanoBneno c.ne,rTyKnuee: B npaBofi
(1)010 76. Boahnon r.
1-1a6ntopeinte 26. Kamm-
ttecultil anaritoo: pat:
ripaBoil rpyanoft 1KCJIC3b1
II cTaamt. ritcTonortitte-
mil intorno: narmangp-
Ilan apenonpuntioNta,
tin nepecmoTpe - na-
unnimpitast apettoma.
15.IX 47 r. rlICT0a0rIPIC-
CKOC cTpoemte opium) 113
24 y3,110B, npouttohmato-
utux rpyanyto )Heneoy,
nepea nannom Kypca
111113CKIII1r1 npenapara. B
rpy6oil COCHIIIIII1eab110-
ncamtofi ocnoBe nepaBito-
Nteptioil BC.111,111111,1 H (imp-
MbI - HOHOCTII, Bb1110J1-
11C1111b1C COCOHKOBbINIII
poopacTattunnt, tIpC3Bbl-
gam nonnmop4mhnitt,
nonhiThie unnunapittle-
chlINI 3nuTenttem. ?attar-
1,03: nannannpnaH ape-
nonmuntoma, Bpi! BTO-
p11,1110N1 aniline Tex Hie
NW,? upenapaToB - Hanna-
asuman apetioNta
Bontmati nplinna 155 mrhenuil npenapaTa Ha nom:Henn 5 mecHueB
(157300 cumin) floimepranch o6paTnomy poomrrino it tictleoint B nottecce
aeticilitsi 24 yopa. Bhmocume B mann )Ke.neoe 3a nocneptine nopTopa rop,a, n
ABa HJIOTIIbIX intmcnyona B npaBoil nopmhimetmort Bnaatme
(Duro 77. Boahnon r
16.1 48 r ritcToitormie-
CHOC CTpOCIIIIC onyxonn
BO 'moist JICHCIIIIH (101
mrhemum). KapTinta KB-
C103110r1 macTonaTint CO
CKTICp030NI II Ile60abWOr1
tinclutahTpauttect Hpyrno-
WICT0,111bINIII 3aemenTamit
COCHIIIIIITCJIbIlOr1 TKaHll
nonyr }Kej1C3IICTbIX X0-
H0B. MCCTaN111 B iKCJIC311-
mix npocBeTax o6napy-
Minato-1TH COCOHKOBbIC
poopacTating c 6oraToil
rnannintonponintoil cTpo"
moii II 60.1bWa 11111,CKHII-
Crl Kp013C110C11bIX cocypoB:
nottunannost apettoma Ha
4)one 4m6p03110r1 macro-
naTutt
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
?
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
(Doro 78a, 6. Bonbnan F. Fncronorutleme crpoe-
nue ynnorneunn, nonanntherocn BT0p1111110 nepea
3 i%tecnua nocne omnrianun nepuoro uypca Innen-
anti Cmewanuan naprima 4n6po-anenomb1 u
4uu5po3uo-uncToanofi macronarnu e 061L1bHIAM
panurrnem rnannunanponannort py611.0130ri TKaH1t. B
qaCT11 )KeJ1e311CTbIX y3enK013 o6napy-
nu13aercn Kapruna arpocim >mamma TKaHII ii
aametnenun ee hionon,oft 6orarofi n.neruamu cpil6po3-
TKaHb10 (10.VI11.48 r.)
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 ? CIA-RDP81-01043R001900080003 6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(1)oro 79 Boabli a Ft 0.
11a6:no.iettne 27. Kamm-
iteeKitit Attarno3: aernio-
1epaT03 st3E4Ka. ritcro.io-
ItitecKnit .ittarito3 napa-
Keparo3 ilepea natta.Tom
IttrbeKuttit tipenapara I la
Eepxtteil 110BCpX110CTI1
B3b1Ka 110 cpeattert
min ? yttacroK n0pa:Ke-
WIH pa3mepom B 1,5 CM
nertpaonabito onaobitort
cf)opmbt, 6e.ioro unera,
InepexoBaTuft,
MAI Ha 0,1-2 Cul, ?e-
:ten OT 110pN13.11,110r1 C.111-
311CTOrl aemapKauttointort
amnia, Kpacttoro unera,
nittpintoil B 0,1 CM
(born 80 60:mita:3 0,
20-atteBitoro Kypca
Bityrptimbtwetntux 11111,,CK-
BHA npenapara (16800
eanxitul. flopa./Keinte na-
paKeparo3om nct4C3.10 Ha
ero mecre o6pa3oBaacH
LtacroK, noKpburbal Hop-
M3:161161M Brurre.inem
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(Duro SI Bo M 67 oeT Ba3a.111110-1C2 c.tt B uenTpe?S13Ba, 110-
1.ph!Taft crpynom ija nnoulamt 1,5X0,5X0,3
i ? ,
; I
'
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
cl'oro 82 YliacToK myabritcpopmitoro pai:a 6o.mliort
M. :to aetteinin
(1)OTO 83 YtiacToK Tat }KC onyxonti, npit 6o.ribwont yisenititetinif
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(I)oTo 84. Onyxoab 6o.ribuoil 111. aocae :whew's] W1130TplffialllIbIN1 ispenapaTom,
1311,111b1 o6lunplibte Ilona onyc-roweitita 3.10KatleCTI3e11110r1 TKIIIIII, manoe yBe-
;ingenue
(Duro 85 Ta *tliC onyxoali aocae :whew's' 1111130TplillaHlibiN1 apenapaTom B113.-
11131 arpocimpylowiteca paKouble K.nermi cpc.aa alimpou.arapiloro awintabrpara;
6o.abusoe yamithemie
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
04-r
? :,!".
B. ? c. ?V% ? :x,'1: ? ?
?1
;; . - ?
- ????? ? ? y ? ? s..$ ;???; ??
d
i}',;?? 01- / s"fail ' 4??
PI 1.%," .9.: 41 ? .1
(1)0y10 86 011y,i0j1b 6001,1101i 111. BOC.IC nelsons's'. Bilaubt ieiii paKouoil ma-
nn c aTpofissfpylow,siNnicss paKoowns KaCTliaM11, ia.qoe yficassficissfe
(I)oTo 87. YffacToK onyxomt Goabisoil r Ao .ffc?scisoss KapTsina
comf,mforo paKa Flomsmopqnsble wiefoot pascoubsx liACTOK 33110-
B cna6o pa3MITOil i0jjOKlUICTOHCTI)ONIC
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
*010 88. YilaCTOIC 011P0.111 60J1b110r1 r 11.0 .1101C111151 B 011yX0.111
MilOr0 NIIIT03011, 60.1bWOC
(1)OTO 89, 011yxwm (gmbliort I. 'mem. Aciiviimi
06pai1Lacr un te(Isi imIthtatlite (1)opstbi
pattoilidy. KneToK, Milonte ? ntt-telixIIMO-
11.11acTilica paiwiibtx vieToK; X600
1 _ .1, Prti'
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
1
3A1ionomEp11ocTn .nEncTinin w1I3oTpnnAn1Ioro. nPETIAPATA
113
rpyltuort )Ke.ne3e npn noxisinnt npaHort ppm Ro ropn3ouTa.nbnoil .1111}11111 13
0(1'mm! lumne-napplatoro Knaapairra HC110 o6o3nagaeTcH ray6oKoe BTHJICe-
1111e KON(11 B BILle np01J0J1b110 pacno.nmeHlloil CKJIBAKII. npn ouvnbulainin B
3TO1 yqacTKe onpue.nneTcn onyxo.nb pa3mepom 2X2 CAI, mainco-6yrpncTas.
11.110T1la51, no.n,HithataH no oTHomeinno K Kowe, 3a HcKamettuem Toro yitacT-
Ka, Ha KoTopom o6pa3yeTc1 ,sTmenne npit nommort pyKe.
B npaHoil noambiwetwoil Briaanne ? Aim 17J10T11b1X Jnimg)aTntlecxnx
v3.na. 0,a,m1 113 y3J1013 nccetten .71.12 rncTonornnecxoro nccae;:konannyi. 3amo-
nenne: ?meTacTa3 aaenoxapunnombm.
C 7 anrycTa 1946 r. nanaTbt nirbexunn npenapaTa. B Tetleinie nepHoro
roan Ha6.7no,aettitH 5o.nb1ta1 C. nplutst.na Asa Kypca turbextuift c HitTepHa.nom
n 40 Aneii.
17ep8bta Kypc npop,o.inKaacsi c 7/VIII no 20/XII 1946 r. B Teuealle
41/2 Nlecfluga 5bi.na cfle.natta 121 HirbeKu,HH.
Flpenapar BB0,111.71CH BuyTpumbutienno oann pa 3 B cymn, B /103BX,.npii-
11011,11N1bIX B
PIwbeKunii no3a a caninlitax ,UaTa
1_ 9 no 50 7-8 VIII 1946 r.
3? 47 1. 100-300 9 VIII ?22 IX 1946 r.?
48-71 x. 400-500 23 IX-16 X 1946 r
72-93 x. 600 17 X-11 XI 1946 r.
94-121 1. 500-700 12 X1-20 XII 1946 r.
Floc.ne 47 turbexunii onyxwb cTa.na enee Hunymort, pa3mepom
2X1.8 ot, necKanbKo 5o.ne3He11troll npn outyribmanum; noc.ne 71 Hirbeidutu
(23 000 eAninut) ? 6a.nee n.nocKoct 11 ymettbunmacs B pa3mepe tio
1,75X1,5 c.u. IlosepxnocTb cTa.na 6o.nee roaRKort.
11ocae 93 turbeKuHil (35 400 umlaut) onyxoab cTa.na mamma, ymno-
w.eintori.
floc.ne 121 HirbeKu,nit (50 750 exunnt) onyxoi HMeJIa pa3mep
1,5 X 1,7 cm, raaaxylo, naocxylo noHepxHocTb, 6bt.na 110,17,BII)K110il. MINI4MT11-
gectu11 y3e.n B npasort no,ambnneuHort ,BIlaallfie He npotonbtaa,ac.a.
20 XII 1946 r. turbexutin 6bI.T111 3BKOHtleHbl.
B pe3y,nbTaTe nepeoeo Kypca y 6o.nbHoft C. npoit3out,int c.ne,lytoultte imme-
Helium
1. Onyxo.nb, panee nmeHutaH pa3mep 2X2 or, B npouecce lmbeKtouriirt
ymeHbarmacb )7,0 pa3mepa 1,7X1.,5 or. rIosepxnocTb ee cTa.na raa?a
6o.nee n.nocKoti.
2. n110THbIrf .7111N1430y3e.T1 B npasoft numbnuetatoft Bnaxnie ticite3.
no npowecnint 1 mecHua n 10 itHect, B Teuemie KoTopbtx HirbeKun He
11170113BO11.TRICb, 29 Sumps! 1947 r. owl npon3BeHer1 KniuntuecKat ocmoTp.
3a 40 Audi, noxa 6o.nbi1aH ocTatia.nacb 6e3 aetteHHH, noHoo6pa3osaline flpI1-
1151/10 TIJIOTHyI0, xpsnuesyto KOHCIICTeHIMIO, yBe.111P111J10Cb B pa3mepe JiO
2X1 25 cm, cum? CflaBlInbIM C xo>xeft, nonepxnocTb ciaia 6yrpncTori.
C 5 ckenpa.nn 1947 r. 6bm natiaT Import Kypc HH-beKunct npenapaTa,
n 661bu1ix npoTnn npexurero 1io3ax:
Hwhemuni ,Uo3a 13 eannintax
RaTa
1? 15
no 500? 900
5 11-6 III 1947 r.
16? 30
? 1000-3000
7 111-4 IV 1947 r
31-58
2000-3000
5 IV-14 V 1947 r.
59-107
x. 4000-5000
15 V-8 VII 1947 r
Hoene 30 HirbeKunft (39 600 =mu) onyxo.nb ymeHbumnacb B pa3mepe
o 1,4X1.0 CAI.
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
114 utwArnoE P%3131ITIIE 3J10KAHECTI3E11111,1X 0111.X0.?1EH LIEROBEKA II
Ilocne 107 mrbeEwlii cocTonulle onyxonit ? 6e3 H3meitemill. 13a3mep
no-npuutemv 1,4X1,0 CAl, tkopma opa.nbilan, KoucucTenwin ? nnoTnasi.
Onyxonb nonmKna no orlionienmo K ray6mce ite)KatuNt TIcal111M, 3a IleKj110-
tielluem (=tor? ynacrKa, rjie ?Ha, KaK 11 npoKne, cnanna c KO)Keil. JIHmtka-
TnnecKne )Kene3b1 He npoulynbmalarcn. OT onepanim 60J1b11ag BlIOBb oma-
3anacb.
8 1110JIH oKoHneH aropoti Kypc 111113CK11,1111 npenapaTa.
B pe3yabTaTe sropoeo Kypca HpoH3oHinu anenyloutme 113meneuitil.
I. Onyxonb, Koropasi 130 epemn Hepepbma me)Kny nepnbim 11 BTOpb1M
Kypcom, sbipoc.na ;to pa3mepa 2 X 1,25 cm, Ha npoTmemni cropoco Kypca
mrbentitil 13H08b yilefibl1111.4aCb no pa3mepa 1,4 X 1 CAT.
2. YMel1b11111B111HCb B cnoem pa3mepe, onyxonb cra61uzu3uposadzaco 11
npon.nemie Kvpca ewe Ha rim memo He nonnemo 3a co6oil ee na.nbtreiiwero
yMeHbilleli1151.
TaK 3aKolltinnen nepHbni ron, ria6.11onelimi.
Hatpins-1 c 310r0 ppemenu C., XillByllIan B )1pyrON1 ropone, npticmmaeT
mrbeKtutit Heperynnplio, nepepbmbt CTa11013SITCH nacTbimil, AJIIITeJ11111b1M11.
Kypcbi turbeKwi( Kopomnmil, Oanbnan no;tonry omens' 6e3 aeneunn, KaTe-
ropHnecKu orKa3bma51ch OT onepannit ,ane TpCTII ppemenn B Tenemle nTopo-
ro rana na6nianeHu5l 3a1mmaioT nepepbmbr 11 TaTIbK0 TpCTb ? HIIIC1111111.
BOT IIX pacnpenenewle BO npemeim ii Tenenue npil sTONI 60.1e31111.
8 VII-8 X 1947 r.?nepepbts 3 mecnna. B nepnble nma Niecnua onyxonb
coxpanner CB011 npe)KHHe pa3mepbt, Ho 3a-rem yne.nwinnae-rcn no 2X1,75 C.M.
B OCTaJlblIOM HpH3HaKil OCTTUOTCSI
C 8 X no 2 XII 1947 r. ? 46 HirbeKtuni OT 1 000 Ao 3 000 eninnw int
HirbeKumo, mem 81 000 ennunu, ? ii cuona nepepble Ha 127 /well. Bo
epemn 1111-beKunii pocT ocTananniMaCTC51. B nocneHirbemuloHnom nepHone
onyxonb Taicmce ocraeTcn 6e3 H3MehIcrhrrii 6anee Tpex mecnu,en. 3a-rem Haim-
Hams! pod. Pa:1wpm ynenlicummoTen no 2X2 c-.1t B COMM! 113 cermeirrou
1-10518.11HeTC11 mum 6onee n.norubil KOIICHCTC11111111, nem ocTanbitan Liam ony-
xontr. Bonbilan BlIOBb arKa3binaeTcH OT onepaulm.
C 24 III no 24 IV 1948 r ? 31 111113eKHHSI ? 48 000 enninius. flopa-
)Kelme oc-raeTcn 6e3 BIUHIN1131X 113mellennii. BOjIblIa51 ne.naeT nepepbm fa
17 nueil, no Hcrenemut KoTopmx K.THHInnecKnii OCMOTp noKa3bffiaeT npem:ipie
ero pa3mepbt ? 2X2 113meltem151 o6Hapv:Kilealorcn B xapab-e-
pe onyxonu: 11051BILTIIICb yttacTKH B mine 6yrpncTbix wimon xpnweeoil Kt)11-
cacreamm, IIIITHM110 cnn3aHltbie c napeuxiimoil iKene3b1 Bonbnan BI101313 OT-
Ka3bt3aeTc51 OT onepaumi.
C 11 V no 11 VI 1948 r. ? 26 mrbeKunil )1,03aMII OT 500 no 5 000
emumn. Ilepepue 18 j111Cii. C 29 VI ? 17 HirbeKunii no3amH OT 2000 no
5000 eAmnin. Onyxo.nb ocTaeTcn B npe)Kilem COCTORIIIIII. Banblian ne.naeT
11013bIr1 nepephas 11 noanpawancn 2 anrycTa. fIpH na.ribnawni onpednenneTc:i
ysenmenHe HoPoo6pa3onalm B Hanpannemin B Tonwy ?Ke.nent. OT pull-
KaJibhroll onepawni 6albilan orKa3bleaeTcn, 110 naer cornacHe ira drpalin-
nentioe HcceneHHe onyxanii. 21 anrycra 1948 r. 11p0H3BORIITCH mceneinie
onyxonn BM eCTe . c oxpynaionteil )1:Hponofi KneTnaTKoil ii napeipalmoil rpyA-
Ira )Kene3bi pa3mepom 7X5 Cit. IncranormtlecKoe Hccnenonaime noNa3b1-
Baer, trro q6Onbwan 4aCTb ynazeimoro ynacenca COCTOHT 113 )1(Hponoii KJICT-
qaTKFI, B KoTopofi 3anmella rpynna C:11113a10111,11XC51, HenpanH,nbirbtx onevra-
mni, NienKrix 6enonamix y3eaKon o6wirm nHameTpom 01W.110 2 Cit, Hmetouttlx
crpoenHe aneHoKapumlombi c o6unt9Hbimil rue3namH co.ntinuoro paKa?.
B0.11bHaR npuHHmaeT I4IrbeK1111 11, nankman co 2 anrycTa rio cpenpa.rrb 1949 r.
no-npemulemy c nepepbn3amn, B ceirrn6pe ? B Tenemie 10 Ana, B Hog6pe-
15, B AeKaope ? nmsape ? 45 H copcem npeKpautaeT HX B 1950 r.
31\1(01101%1E1110CM ;11.:11crinni 11111301'1'1111A1111000 1111:11APATA
115
Houle oneparneudro yna.newin onyxonct Ha npoTmellint rana optima-
KOB peuununa H meTacTa30n He o6HapymnaeTcn. Ho 3aTem nonannercn pe-
onyxwin B rpynHoil mcene3e 11 meTacTa3 B JierKom, OT KoToporo 6onb-
Han nornoaeT.
Ha6Jnonenne Han 6onbiloil C., onHcalnie nimaNtinui 113meHeunii y nee
onyxanH II NteTacTa3on noKa3bumeT, tITO B nepHonbt, Korna umoTpllualmbni
upenapaT nocTynan B opran13m ? onyxanb npeKpano.ria
pocr HAH ymenbitta.lach B pa3mepe, B nepitonbi, KOr,r1,a HIMCKUHli He f100113-
1101111A 011yX0U1b nammana To panbwe, TO necKo.-mo no3nHee pacTm.
Haamonewie Tame 110Ka3bI3aCT BO3N10)KHOCTb BJUISITb Ha pod r paKonoil
onyxann TORM0351W,IIM 06pa3OM KK B neprultmom, TaK II 8 1108TOpHbtX I(VpCaX
IrirbeKuil i: V 00:113110i1 C. IleplIOAlltleCK11 nowropniouteecn Top:mom:elute npo-
no.ipKanocb OKOJIO 3 JICT, noKa ona nmena BO3NIONOIOCTb 11p1iMe1151Tb 1111130-
TpIrnaIulbIu
B acneKTe nocTamelmoro Hamn nonpoca o pecl)pawrepHocTll, HeoCixo?
Immo nonneplinyrb, nTo y 6onbnoil C. pecOpmcrepHan peaKuHn, no HatueNiy
MIIC111110, nponpunacb B nepnon pToporo Kypca HirbeKijuhi, orna onyxonb.
Hmenwas AO Toro pa3mep 2,0X1,25 Cit yMellblilliBILIHCb AO 1,4X1 fit Ha
upormelaw nepsbix 30 HirbeKumil, 3aTeM cTa6H.111311pona.nacb B TaKom CO-
CT051111111 II He 113MCIIII.T1aCb 13 ,n,anbuernnem lin B 1113 B KO1ICHCTell-
I1j111 no/1,1311)1:110cm Ha npoTrimmut cnenylotnnx Tpex mecnues IiirbeK-
upopporo Kypca. Ec.nn no3A1!ee, B renemie nToporo rona B nenentat 6anb-
11011 6brn cytu,ecTnelmblil ne(i)eKT, 3mmo4anam11cn B tIaCTbIX Bb1Hy)Kae1111b1X
Hepepbtpax me?Kny illrbeKuHsIMII, trro Hecomnenno Becbma nnoxo arpa?Kanocb
Ha 1)e3y.lbraTax. TO B Tenelme nepnord rona 1111 B neppom 1113 BO BTOpOM
Kypcax -cal:11x nepepbrnon He 6bLrio. Alem:ny TCM, HmeHlio B nepHon nToporo
Kypca B 6o.ne3HH Ha6monanHcb KK 6b1 nne pa3Hoponlible peaKwm:
IlepBbIC 30 turbeutHil Bbi3bIBa.1iI KalutepamminecKylo peaxtuno H COI1p0B03K-
Jamicb Kamtepo-repanemptecKlim 3(1)(1)eKT0m, nocAenylowne >ie 77 H11-beKunii
ocTanamicb an6o iren,efiCTBHTeJIbrrbTMiI, JI1160, t110 6onee ripannnbHo, oxa3ann
Kwit(epocraruttecKoe neficTelle 6e3 nocAenyiouteil KaHuepo.nTITIltleCKOil peaK-
111114, TITO l3bIptl.311.10Ch B crab-H.1mm= COCT051111151 60113110U. COEIOCTaBTISUI 310
Ha6.nionenue c tra6aloneHHem an, 6anbiroci fl. (c-rp. 110), Han? OTNIeTliTb,
tITO B 06011X 3T1IX c.nyitanx pecppawrepHan peaKunn BO3HHK.TIa H nonnmacb
Ha cmeny npex:Heil TIVBCTBIITCJIbITOCTIi. OnitaKo cywsec-rnetman pa311Hua 3a-
KnionacTco B TOM, LITO V 6onbn0Il C. cocTonwle pecl)pawrepnocTil 6bIn0 OT-
HOCIITeabHb1M, TK KK IrrrbeIcwrlr ripenapa-ra AtHowtipartio npuocrattaeizuea-
All pocr onyxonn 11 nonananzu o6wee pa3MITIle npouecca, xo-ropbril nporpec-
cHponan B nay3ax NteKay MIMI!.
Cne,ci,yeT pcnommirb, t1TO n,o Hatia.la HirbeKuml y C B Tenetme 3-4 me-
omen onvxonb, HmeHluan paamepu ropowimbi, ,B4OCTIMTIa Be.1111,11111bI
2X2 CA!, a B noambnuenHoil o6nacTH o6pa3ona.cmcb MeTaCTa3h1, Kaimpomian
npupona Ko-r0pb1X 6bI.T1a VcTairoeneira rncTonormecKH. C.nen,onaTenb110,
umarpunamioro npenapaTa nattanit npon3nonwrbot ?00.91311011 B
COCTOS1111111 ranoncipvioutero 3.noNanecTne1moro npottecca:, KoTopbm 3aTCM B
neptron .nettemin B npnmoil CB 513I1 C IIM11611TOpHb1M nencreHem npenapa-ra
npHitn.ri coaepaielmo 1111013 xapaKTep. KK 310 51BCTBNCT 113 anneal=
TaKum o5pa3om, peclIpawrepHan peaKuun, Nto)KeT HN1eTb pa3H3'lo c-reneHb
II MO)KeT HPO5IB.151TbC5T J11160 B 110.11110r1 noTepe TIyBCTBIITCJIbHOCTII K 11111301p11-
narmomv nperrapaTy, JI1160 B Torna HacTynaeT TOJIbK0 Katufepo-
crartyteciata 3c1)(1)eKT 6e3 nocaenyiouteil 'KaHnepomminecicolt peamuni, Kw:
3T0 6bmo y 6o.nbHoil C.
Mb! nonaraem, tyro Ann allann3a npo6nembt pecppawrepirocTH oco6oe
3patieune npenc-ran.nneT claim 113 immix nepnbtx Ha6morcentlit Han, Tenerniem
pal:a V 60.11131fOil E-B0r1 (Ha6aloAemle 30), o6paTneuteucn B KAHHin:y B mae
8*
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
116
OBPATHOE PA3B11THE 300KALIECTHEIIHMX onyxoAKH HmoBEKAII
1946 r. KaummecKnfi ocmorp 110K:13aJI c,ne,uromee: B Bepxne-HapywHom
KBaapaure .neBoil rpyuHoil >Ke,11e3bI ? onyxanb n.nornoil KoHcncrenulln
6X7 c.u. B 110AMblWel1 110ii Bna,uune HecKoJmKo IIJI0T11131X.
yBCJIII-
tCItIthIX awmpovinon. 0,Tom H3 11 11X 11CCetlell non 6noncnn zjjin rncro,nornue-
cKoro Hcc,nexmawm. 3aKmottetme: meracra3 aAenoKapunHombl. Or onepa-
qua 60.1bHa11 KareeoputtecKu orKaaa.zacb. B TOM we mecnue Gbiz Hagar Kypc
13HyTpliMbIllIet111b1X lit unmorpHnannoro npenapara.
lloc,ne 80 mrbeminii (7000 emmnu) npn ocmorpe yCTBI1013J1e110: ?Ha me-
m 5bmweil onyxoan rpy,rwoil weae3br ?mum, HeKoropoe ymnorHenue?.
E-Ba ()bum Bunncana 113 Iij1 II 11 1(11. Hirbexunn npeKpamenbi.
17 ceHrn5pu 1946 r. 6anbHau BHOBb 6bma craunoHnpoBaHa, Talc KaK 3a
BpeMSI nepepbma (oKo.no nanyropa NiecsuleB) mum BhIOBb nponLynbmarben
01IVX0j1b C rpeuknii opex BeJi1Itnhloif. BlIOBb 6b1an Hagan' mrbeKunn.
Frocae 69 IIIIICKUHrt (32 900 eJmum) KoncrampoBaHo: ?onyxafitt KaK
TaK06011 He npotaynbtaaerc.g. Ha mecre 6btatueti onyxam recroo6pa3Hoti
KoucticreHattu ylmorHenue, 6 T0.411(e Koropoeo HeCK0,11)K0 KIICT006pa3HblX
tua-
puo.>. BanbHau npeKparima mrbeKu,un Ha noaropa mecuua.
Bo Bpemu nepepbma BHOBb Bbtpocaa 011yX.W1b It 11p1I ocmorpe 8 sumapn
1947 r. ee pa3mep 6bia ycranomen B 2,5 C.m B Anamerpe. Koncncrenunn
cra.na noornoil KK xpsnu. Banbnan B0306HOBIIJIB mrbeguim. OAHaKo 3cp-
(beim 6anee tie Hao.nmaanocb. Onyxo.nb nocreneHuo yBe.rmwma.nacb, BILOBb
CTBJIII Ilp0111,yIlbIBBTbCH AHNupoymbi, nocreneHHo onyxo.nb AOCTIIMB Toro we
pa3mepa, HTO It 210 :mum's!. Oneparimnoe wia.neHne ocra.nocb oe3pe3yab-
TiallbIAL B nerKux oopa3oBaacu N1eTaCTB3. BOJIbIla2 cKoHHaaacb OT renepa-
jIII30BaIIII0r0 npouecca B Mae 1949 r.
3ro Ha6.THoaenne nmeer 6o.nbume 3ilageitite A.T1H nouumaunn coowHoro
npouecca perpeccHH paEoBoil onyxodm 11021 BJIII5TIIIIeM 6no.normecKoro ripe-
napara. C oaHofi cropoubt y oanbuoii 6bIJI AOCTI1THYT B nepBom H BTOpOM
Kypcax mrbeKunil ncK1HounrembH0 BbICOKIlrf 3(JH1)eKr: asteHoKapulmoNta BeAH-
411H0ri 6X7 C.It c meracra3amn B pe3yabrare mcbeKunfl 5o.nee He npotayabl-
aaitacb. 1-Jej1b35I He npn3Harb raKyio crenenb perpeccnu Becbma BbICOKOli.
Bmecre c rem Bce Aa.nbnefiwee reuenHe yoew,naer iiac 13 TOM, HTO npn nourn
nannom IICHe3H0BeIIIIII OTIyX0j1 II, B rpyuuoil we.ne3e ocraBaancb no.rmoueEmble
3.noKauecrBenubm K.nerKu H B nepepbme meway IIlFbeKUlI,IMJI ,naoll 'mum?
110130My (j)opmnpoBaHmo onyxmeBoro y3.la H nmurom pe3Hcrenruoro B OT-
iroweini um3orpnnannoro (I)aKropa.
Taimm o6pa3om, B 3TOM c.nytme KainumecKoe Ha6sHo2ienne ,Lmer ocuo-
mime AyMaTb, LITO B KOHMKTe C unmorpunammtm npenaparom moryr
OCTHTbCH )1CII3HeCTI000611bINIII pe311CTe1ITIIbIe i Hemy K.nerim, B cn.ny tier?
Aa.nbneilwne HnIeKunn Ha pa3Bnrue onvxam He ma3bmalor 34upeKra.
HmeHuo Ha6mo21eune Ha,n 6oabnoii E. nopouHao MbIejlb npH5er1rb K
yam-emu? nepnntmoro ()tiara y 6o.nbirbix paKom rpmnoil )Ke.ne3br B momeur
perpeccun 0flVX0Jii. BbI3BaHHOil LIII130TpIITIBIIIIbINI upenaparom. IKai MbI BII-
Amu paHee 3TOT Nrero,u 21aJr xopomne pe3VJIbTaTbI.
Ha6mo21erme 31
(B 1945 r. onncaHo no Ar2 11)
BanbHofi M-OB, 55 JIT. PaK 11p51,1101i KUIWCU. B Ntae 1946 r. CianbHort
IlOilyBCTBOBBJI 3arpy21Henue npu ,Lteci)eKaunn 11 o6Hapyw1r..n B Ka,ne Kporm.
B reueHue c.leapomnx 10-15 21Hefr umemin Hapacrami. C nepBbix Auer!
1110HH npeKparnacu CaMOCTOSITeAbHbIr1 crya.
B IjJ1t1luKv nocrynno 8 \TI 1946 r.
Hcc.neaoBaHne naimnaunen. Ha 3a211-reil creuKe npumoii ICHMKH, B 5 Cif
or aumbHoro orBepernu, cnpaBa or cpe_nHeil onnunn, naornau 6yrpHcran.
3AKOHOMEPHOCTH AEIICTBUSI IIIH3OTPIIHAHHOF0 HPEHAPATA
117
pacna/mioLuancu onyxo.nb. CreuKa KI4IIIKH BoKpyr onyxwm mulmnbrimpoBa-
Ha. Be.nutmny onyxam najjnawie TOLlIlO ycralloBurb He yitaercu, BBH/Ly
HeB03MONC1tOCTII JiocrHrHyrb naabuem Bepxneil rpanHubt onyxo.nH. Bnallmau
Haub ee mien pa3mep npH6Jumnreabno 3X3 au, 8 VI ?6Honcnn. rn-
cro.nornHecKom ucc.ne/loBanun ycraHoBana alteuoKapuHuoma npumoil KHWKII
(3aK,mottellue 3acay)KeHHoro Aeureou HayKH npock. B. T. Tana.naeBa).
14 VI 1946 r. 60.nb1ro1y &um Hallam1 mrbeKuun npenapara. HfrbeKIIHII
TIPOH3BO21HJIIICb ofum p133 13 cyrKH exce21HeBHo BHyTpIiMbIWetIHO '13 uro,untmym
o6.nacrb, 6e21po It B o6.nacrb crumb! nootiepeAno.
,LlaTa
14 VI
15 VI
16 VI
17 VI
18 VI
19 VI
Ihmesnim npenapaTa 11 commute onyxosn
FhrbCKRHH
-H
3-H
4-H
5-H
6-H
403a
is enunnuax
20
30
40
50
60
70
Bcero 270 eammu.
19 VI commute onyxam: npn na.rmnaunH ycraHomeno 3HauHrenbnoe
ymenbweune nnclmbrpara mum" KnumumiKa. 513Ba }weer xparepoo6pa3-
Hoe yrAy6.1enHe, nponycKaKnuee KouunK nanbua. BH,n,Hman Liam onyxann
ymeubmn.nacb ;to pa3mepa 1 X 1 cm, HaBHcaer co cK,naAKoil r10-
SIBILTICH CaMOCTOSITeJlbIlbth CTYJI; AecpeKaunu CHjIbII0 3arpy21meHa. B Ka.ne ?
ICJI011bH
Pena' reHorpamm a. Ha cHnmKe npumoil KI1U1K11 noc.ne Hammel-mu
ee KoHrpacrnort maccon c noc.ne,aymumm? onopowHemiem?AecipeKr Hanarme-
HUH nporuwenHocrbm B 4 C.3I Ha paccromm 5 Cit OT aHaJlbH0r0 OTBePCTHH.
npoltonweitife MfbCKHIlli
flan Fhrbesunsi
20 VI 7-51
21 VI 8-H
99 VI ?27 VI 9.H-13-s
28 VI 14-s
29 VI ?30 VI 15-H-16-H
Ro3a IS eannintax
80
90
no 100
120
no 150
Bcero 1300 e,runnnt
30 VI xiecpeKausi ieitee 3arpy,EmeHa, cry.n camocroure.nbHmil B reuenne
Hoc:maim "well.
lipoixon}nenne infbesnnil
1 VII-5 VII, 17-H ? 21-u no 150, Bcero 2 110 exiimu.
5 VII. IloBpexHocrb anyxwm cra.na 6o.nee roaAKoil (na.nbnaunu). Pa3-
mep l3ILli-IMOU onyxcon ocraercu 1X1 cm.
Ilepaol,anozealle HirbeKH,Hfi: 6 VII ?10 VII 22-H, ? 26-u no 150, Bcero
2860
qe1.0. VII. Kparepoo6pa3Hoe yr.ny6.neHHe yMelibWHJIOCb.
Onyxo,nb cra.na 6wiee nzocKocf. Ithalu mm m
nbrpar creullein-ma 3amerno
mu
rIpaLtoawerme turbeKunii: c 17 no 30 VII meounenno no 150 exinnu.
Bceeo B 47 HifbeKuirsix BBeAeHo 6010 exiHnu.
npclassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
t
118
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
- -?
0G1'ATII0E PA3BIITIIE 330KAUCTBEIIIIIIX 01I3'X0JIEn 4E:Miff:KA II
30 VII. Ilpit na.nbnaTopnom nce.ne,rtoBanun B Knwetutoii mime He o6Ha-
pyxciteaercs flu on yxonu, tut ututmiziapara. Ha NIecTe 6banneil onyxo.nu ynAoT-
HeHne pa3mepom enee 0,5 X 0,5 au, nawiewoutee B mute eK.na,mot. 06utee
eamonyBeTBne 60JIblI0r0 xopowee; CTyJI Bee Bpemn CaMOCTOSITeJlbnbIii.
reAtaTonoeugeocue uccAeaouaniut. B Tenenne Kypca mrbeKunil rwena-
paTa 6bu10 npon3Beaeno HeTbrpexKpaTnoe nce.neaoBanue Kpomt: B item, nen-
BOft wrbeKuun, 3aTem nocze 6, 14 ii 43-ii
Ilpit 113plelnin kpacuort KpoBn oTmonewili OT 1101ThIbI ire o6napy:Kunoeb.
KOJIIILIeCTBO apirrpottuToB, yNteHbumBweeen u Hana.ne 6o.ne3nn, 3aTem
BOCCTall0811.10Cb. KoautteeTBo remomo61111a OCTat3a.40Cb C neKOTOpb1M11 !MAC-
Cialummu npitmepHo Ha 0,11110NI n TOM )Ke ypoBue.
PeaKunn oceitantist apirrpowrroB coxpann.nrm, nonTn 'fa mum! n TOM
>ice ypoBne, ocTaBancb BbICOICOrf.
06mee Kannnemo .nefiKouirrou B Teuettne Bcero Kypca mrbeKunii no/t-
Bepramcb ne3nantrre.nbubtm 1oAe6altunm, npORBJ15151 Ten:tenant? K =interim
K KOnIty .neitentin.
B unTorpamme ?e.nofl KpOBII MO)KII0 6bIJI0 OTMeTtab neKoTopym Juinicim-
mouoitirrapifylo peaKuum: noc.ne Bpemennoro najleinIn JIIINHPOWITOB ira 6-ii
/ten mrbeunpoBannn KOJIllneCTBO wuton.oepnbix 3J1eMenTOB KaK .Inumtpoutt-
TOB, TaK Ii MOHOLUITOB BO31)OCJI0, AOCTIIrnyB B o6w,em 29,5% BMeCTO pauee
6bwuntx 25%.
FIcuuntymeapnan peaKunn ocTaBaoacb 6e3 mmenennn.
OGilitee COM/11111C 6onbnoro
Balbilort HOCTVEIHJI B Hammy npu OTCyTCTLIIIH eTy.na B TeHenne 2 ire-
Ae.nb; o6mee KawntneeKoe cocromine onpeitean.nocb KatuntuncTamtt, KaK
commute cpenmeil TypKecTn. B Teneune nepBbtx AByx ne2.te.nb noc.ne naga.na
mrbeitunil ocoobtx mmeneurdi B camoHyBcTBmt ire nacTyna.no. Bpemenamn
1105IBJIHJIC51 CaMOCTORTeAbnblii cTy.n, axtaKo AetPeKaUtin 6bma 6o.ne3nennoii,
TpyRuoil, conpoBoKoa.nacb otoe.nennem KONIKOB, unoraa c npti-
mecbm KpoBn flepBbifi CaMOCTORTeAblIblii CTyJI, 6o.nee HMI Nienee 6e36o.ne3-
11e1111bIll, nORBILTICH noc.ne 17 nirbeitunft ii3aTem cTa.1 pery.nnplibim. Flo Bpe-
meuam B Ka.TIOBbIX maccax umezacb lIpIlMeCh CJI1131ICTbIX KOMKOB, TO 60JIee,
TO meuee ()ammo oupawetnibix KpOBbi0 flocjie Tpexneae.nbuoro Kypca
uirb-
6b1,1 oTmenen nepe.nom B o6mem COCTOfillnli 6o.nbitoro,
KoTopoe 6br,no onpeae.neno kaK ?Bno.nne y1LOBJIeTBOpMTC.rr iroe ii, HaKoneu.
NaK ?xopowee?.
Bec noc.ne 6 mrbeKunii Ohm 50,1 ice, nocze 21 rurbettunn 50,2 Ka, noc.ne
44 rrrnerIce necTatmapTUoro npenapaTa, npui Bcex AapeicTax B meToArt-
ice .netiernin MbI ita6.nlo1Ia.nr1 y 6?.nbnoil Ii. KanuepoTepaneBnikecKnil acpcPeKT
$,Ba>1{Ab1 n o6a pa3a B 3riatniTe.nbuoil cTeneint H nepecTa.rin ero i1a6.nroAaTb
rop, cnycTn, npit ?Alta H Toil >ice meToAuKe inroToB.nentin npenapaTa, XOTS1
H AaLlerco necompweinioil, HO oxiitaicoBoil B Tetreinte Tex 21/2 .neT, KoTopbre
nanytia.na npenapaT 6o.nbitan 11.
Y 6o.ribitoil E. perpeccun 6buta CTOJIb 311a111ITeJIblIoil, tITO 011yX0.11b pa3-
mepom 6X7 or ire npoutynbiBanacb. 3aTem nirbeicutin lie OKa3bIBaJIII 34)-
(Peicra.
600brioil C. 6buta KolicTaTirpoBaria 3natinTe.lbtian perpeccrin Ii B nep-
BOM Kypce H B riatia,ne BToporo, 3aTem itacTynwno KanuepocTaTiitiecKoe Aeil-
CTBIle 6e3 noc.neAyrouteil KanuepanirrutiecKoil peaKunit. -3TO >ice OTHOCIITCH K
60J113110Nly M., umememy aitettoKaputniomy npBmoil
Talcum o6pa3om, y irac nu ocirotainin OTHeCTII (BO BCHKOM c.nytme no,n-
tiocTbio) 3a ctieT KatiecTBa npenapaTa 6e3pe3y.nuraTnocTb ero npumettemin.
3TO 06CT051TeJlbCTBO 3acTaimneT "Lyman, tITO B ornicatinbtx na6.nroAent151x
Mb! unjieJriI y 60J1bIlbIX nommirtylo pecpparcTepilyro pearcuttio.
?Altaic?, npnirsm Taicyro Totncy 3pe111in, Mb' J111111e1IbI cpakroB, KoTopme
1103B0'.7111.1111 Obi nam ynciniTb mexartu3m B031I111(11013e111151 31011 peaKunn ? C1351-
aaaa Jul ?Ha c pe3ucTenTit0urbio caNnix 3J10KatIeCTBeIlHbIX KJIeTOK, n.riut o6yc-
.11OBJlelta onpeAe.neinibim cpuno.nornnecictim COCTOSHIlleM opraint3ma, pa3B11B-
WCMCSI B npouecce
Tpy,atio oTAaTb npe,anotiTeinte oAriail H3 3T1IX runoTe3 6e3 cneullaabilbtx
HeJ1b351 IICKJ110411Tb, tITO B Macce moKatiecTBeinibix KJIeTOK
moryT 6bITb KJIeTKII C painutmoil cTeneubro IlyBCTBIITeJIMIOCTII K 111H30Tp1i-
namiomy anTn6,nacTomitomy cpaicTopy. B npou,ecce itirbeKunct B TaKOM coy-
time ritonyT tIyBCTBIlTenbIlbIe H OCTaIOTC5I pe3ncTei1Tribie xoTopbte 3a-
Tem Aakyr natia.no noBbim pe3ncTenTiimm noicanerinnm. B 3TOM caytiae pecp-
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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9
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
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1 MA, npeae.nbHaH 2 ii.z. 14FrbeKu1IIi npo,u,o,n)Kaancb 2 tecHua. Houle 16 MTh-
Catlin naKeTbi xce.ne3 3ttatinTe.rmo yNIeHbWILTIIICb, 6oint npeKpanumcb, ony-
X0J1b CM0p111,11.71aCb Ii MeHbrn11.11aCb; notwimacb He60J1b111a5I TIOJI,B11)KHOCTb
ttepna.nomr,umbix xpsnuell, KpoBoTeHeime npeKpaTn.nocb. BanbHoil ripti6aBna
B Bece 2 Ke. BBnAy yoytunemm OH 6131J1 BHOBb HanpaB,neH Ha peHTteHoTepa-
nmo 11 nptmHT Ha .nettemie.
25 aBrycTa mule JIelleHli SIno KyTapy B ropTaHn HacTynnao 311a4utTeablioe
yayquielme. Ilpir o6w,em xopowem COCTOBH1111 6o.nbHoil npn6aBH.I B Bece.
CIlyCT51 2,5 roxta 6o.ribHoil CKOH11a.TICH OT Apyroro 3a6o.neBamm. Ha ayTo-
ncnn naTo.noroaHaTomom czeiloB paxa B ropTaHn He o6Hapy}KeHo.
B RaHHom c.nytme nintmeHeHHe npenapaTa Bbi3Ba.no ymeHbuteHne ?fly-
XOJIII. 310 1103BWILIJ10 npltMeHllm peHTreHoTepanmo, HTo paHee He AaBaJ10
HI1KaKIIX Ha,ae)K.II, Ha ycnex, B CB51311 C T51IKeCT1110 nopax(ewitt.
Ha6.rno,a,eH1te aHanortnmoro xapaKTepa 6bi.no npon3Be,ReHo npo4).
B. K. TpyTHeBbINI, TaKiKe HO 110B0,ay paKa cOpTaHII.
K 3T1-tM czyttasim coe,ayeT 2L06aBI1Tb Ha6ino,gemte 34 Hag TetteHnem
me.naHocapKombi. Y 6anbHoro L, 22,roita, noc.ne onepaTHBHoro y,tta.neHnst
manaHocapKombi npaBoro 6e,apa, cnycTH rozr. BO3HHK peintw13 B (13opme MHO-
)KeCTBeHHbIX o6pa3oBaHnfi B 06.nacTit npaBoro 6eApa. Kypc 1.111430-
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
134
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
()I;PkTIME PAMIIITHE 3A0liktIECTBEIHINX 011YX0AEn WAOBEKA H
Tpnnannoro npenepaTa Bbi3Baa perpeccluo pima y3eJIKOBbIX o6pa3oBamiii. 3a-
Tem npottecc o6paTHoro pa313}1T1151 11pHOCTaHOBIIJICSI. BOJIbTIONIY 6bra nplimenell
xypc peHTreHoTepanlin MaCC11BHb1M11,tto3amit. B pe3y.nbTaTe 6bloo RocnirnyTo,
XOTH H BpeNteitHoe, Ho 3amemoe yaytunellue. Mu He maaraem 9TH Ha6.rno-
;Lewi51, xax Ha6magem151, no3BoasHoutue cermac cAeaaTb onpue.nemlyio ?Hen-
xy xom6InnipoBalaroro Nte-rou, H nosTomy He ocTaHaBauBaemcH ira aux 6anee
lianipo6Ho, o,nmaxa cturraem Heo6xoximbim coanaTbcci Ha HHX, noTomy trro
OHII BbLawiraloT ankagy cneu,Haabnoro H33711eHHH icoNt6HHHpoBarmoro meron,a
aetteHun onyxanefi.
MbICJIb 0 BO3M0)KHOCTII 6110-pamoTeparmil, BbITe-
Kaiontan 113 pH,asa KJmHhIqecxiIX 11a6.rnoAelmil, HaxotHIT no,a,gepmy II B o6uwx
coo6pmemisix o TOM, 9T0, noBpeKaan paxoBbte KJIeTKII KaKIIM-.111160 0.11,1111M
cnoco6om, MM Tem CaMbINI o6aergaem Aeficrwle H Ann Apyroro timxTopa.
Eann eTenepb Bce npme,neHHbie Aecteicrbi B II31'OTOBJ1eHIII1 npenapaTa
ii B ero npilmeHettim nepeBecTH Ha xammtlecluirt 513bIK, TO Mb! AOMKribl 6y)leM
KOHCTaTIIPOBaTb caea.yloatee:
1. BOJIbHbIe B 01111CaHHbIX Ha6.nronemix nanyttaxii tteaoaupocatitibui
npenapaT. B 3aBHCIIMOCTII OT cepHit a,o3a aKTIII3H0r0 Hattaaa .xone6aaacb B
npeneaax oautt aecaru.
2. 3a OTCYTCTBlIem MeTansKII KOHTp0:111, 'KOTOPaH B 3TOT nepHon ew,e
He 6btaa pa3pa6oTaHa, Ha npoTsmemnr ypea 111113eKtIllr1 Cpe21,11 aKTIIBHbIX
cepith BBOAII.1111Cb Tame ii eepint HeaxTHBHoro npenapaTa.
PeTpOCIleKTIIBHb111 aHaalla noxa3bmaeT, 1410 113 Tpex larbexullii, no xpart-
Heil mepe, aura I1lrbeKII1151 npo1i3Bo2LHaacb HeaKTIIBHIAM npenapaTom.
IczaHimecicHe ?xe Ha6ala2teHHH Ha A perpecenefi onyxoaert y 60:IMMIX ii
conocTaBaeHne itx c IIHrH6HT0pribiNt AeiicTrmem npenapaTa B sxeneplimeHTe
npuBeau K eaeaytoutemy Bbmony: 5.Ii TO00, itTO6b1 110AytItab 1WMOOICIITeAb-
HbI1i repaneerutteuctia 300eKT, Heo6xoaumo turbetorpoaarb 60.1bHbot exce-
alie6H0 100-200-300 ealllitIlf t111130TptIllaHH000 npenapara, HA:v.3E1(6,w Un-
&WC ItHell611TOPHOZO ae17CT611.5 He Hume Tpe.v. IiHnexc IIHrH6HTopHoro ,Tlen-
CTBIICT ? 310 yeaoHHoe o6o3HatieHHe OTHOILleHIIH cpea,Hero Beca onyxoan (B
RaHHOM caytiae CaPKOMbI Kpoxepa) KOHTPOJIMMIX Heaextemibrx JKIIBOTHbIX K
epenuemy Becy onvxoall ?KIIBOTHbIX, netteHHbix B TetieHHe 15 ,rtHeil c momeHTa
nepeca.rum onyxann. Taxum o6pa3om, 6oabHomy Hallo BBORIITb nO3N B
200-300 pa 3 6oabunre, qem 3T0 Heo6xonitmo ?yin nanvitemm COOTBeTCTBy10-
wero scixpexTa y paKOBbIX mbnuerr. OAHaKO, 11To6b1 cl)opmyanpoBaTb 3T0
ocHosHoe Tpe6o8aHue K npenapaTy c no3IruTrii ICJIHHHKH, Heo6xoximo 6b1ao
HaxonaeHHe onbrra.
3. B pue cayttaeB, oco6eHHo Ha npoTH>xemul 1948 r. iTHatrana 1949 r.,
(50JI1,HbIe nanyitaan itpeamepHo 6OAbtUtje a03b1 XIIAllItleCKU HeonutgeHnoeo npe-
napara, 9T0 (Eax noxasaa n 3KCTIepliMeHTa:IbHb1c1 aHaa113) ymritTo:Kaao no-
JIMIITejlbHblrf 3il4exT, paHee nanytteHmAl OT Toro ?xe npenapaTa B MeHbLIIIIX
no3ax.
4. BOJIMIbIe rrojryqajur nperrapaT 6e3 pera IIHTeHCIIBHOCTII nopaweHHH ?
arum 11 Te meTonllxa H ,103b1 flpHMeHcisnrct, KaK HIM o6unipHbrx 3a0xa4e-
CTBCHHNX H0Bo06pa3oBami5x, Tax II B C:IytlaSiX MeHbWer0 nopmerntn. Dxcne-
pilMeHTbI nce TIOKa3bIBaIOT, 9T0 110:10}KTITe:Iblibifi 3144eKT 3aBlICTIT OT COOTH0-
111e1M51 N1eXCAY mama 3.TroxageeTBeHrioil TKaHH H CTerleHbIO HaebutteHmt opra-
H113Nia aKTIIBHIDIM tkaxTopom o6paTHoro pa3Birrirn.
5. MeTonlixa ripumeHeHnH npenapaTa He SIBASI:Iaeb eneltua.ihHo 1136pall-
11011 MeT0aIIKOH 11 B C1313I1 C 311-tM oHa, BOCbMa B03M0iNFIO, He 6bTaa aOCTa-
T091-10 acIntiexTuBHoll
6.? FlperrapaT npilmeHnacH 6e3 xamtx-a116o AOITOJIHIITe:113HMX (i)axTopoB
BO3ReliC1BIIFI. KoTopbte 6.1aronpHnTeTBoBaan 6131 ero BJI11HHi0 Ha paxoBvio
onyxoab. TO.MKO n03nHee 6bI:10 BbISTCHeHO, 910 TaKI1M 6JIarOrIPIISITCTBV10111-11M
31KOH0MEPHOCTII .11.Ef1CTI3IISI W1130TPIIIIAIIII0r0 IIPEII \PATA
135
MOMeHTOM 5IB.11ileTCH onepanwHoe ymeHbweinte onyxozeBori Niaccbi, a Taioxe,
MO)KHO ,aymaTb, acennitiecluict BOCI1a1111TeJ1bHbIrl npottecc Bb13b1BaeMblri nopa-
)kemtem B MOMeHT 6Honctm Halt HepamnabHoro y,ttaaelnia onyxcall. Tame
He 6bin 11C110.11b30BaH cnoco6 npwsteHemin npenapaTa B cotieTaHmi c ayueBoci
TepanneH, XOTSI K 3TOMY HmeroTcn OCHOBaH1351, nanytieHHbie B HeKOTOpbIX Ha-
OaloAeminx iran paxom rpyxmort a(eae3m, paxom ropTaHH H mezallocapxomoil.
k1TaK, Mb! H13Baall ceilitac 0CH011HbIe a,ectiexTbt na6a1021giu5I. OHM BeCbMa
CYIlleCTBeHHb1. flpamtabHo 6yAer CKa3aTb, 910 KjIHHIPIeCKIle Ha6zioueHHB,
umeBwHe II,eJ1b10 BbISIBIlTb licamtepoTepanewratiecitylo 110j1e3H0CTb ll11130Tpli-
nannoro ripenapaTa CT6611.4lICb 6 UCK.1210talTeAbli0 orszettetutur ycitoeusix. lipa-
BilAbH0 J114 6b1.110 3T0 ReaaTb? CeiNac, nocae npofuteHHoro nyTH, Mb! ,ROJINCHE
CKa3aTb, 4T0 011bIT n0xa3aa IIPaBHJIbHOCTb BO3MO}KHO 6anee paHHero Hatia.na
KJIIIHIP4eCKIIX Ha6J110AeI11111, 13CJIe,a, 3a TCM, KK AiHozoizerHtie axcnepHmeHTH Ha
iKHBOTIIbIX 3T0 nO3BOJIFIJIII ca,ezaTb, a 5e38peatiocrb npenapaTa 6biaa aocTa-
rotwo BbutcHeHa H o6ocHoBaHa.
Momio nOCTaBlab Ham B yripex, 910 K.rIIIHhiqecKlIe Ha6rn0)3,eHl11I Hp0113-
BOAIIJIIICb Oatl08PeMen1-10 C paouroil HaA npenapaTom, a He nocele TO20, ,KaK
IIPO1{3BOACTBeliHa51 aa6opaTopim cmoraa 6bi 11p1ICTYTHITb K BbIllyCKY cTaKaapT-
H0r0 aKTIIBH0r0 npenapaTa. MbI CTaBI1J111 nepe,a C06011 3TOT Bonpoc 11 ripHwan
IC TBemomy y6e)xa,eHmo, tITO no oTHoweamo K palcoson 6ane3HH Taxan no-
eTatioBxa 6braa 6b1 aHruHayitHou H npHBeza 6131 TarIbK0 K 3anepauce B pewe-
HIM ripo6aembi 6HoTepanim palm. flpHtumoil, no6yastmweil Mac HaxanaHBaTb
xax MO)KHO paHbule KJIHHIP4eCKIle ,BAHHble SIBJ1i1j10Cb TO 06CTOHTeJIbCTBO, 910
paxoBan 60J1e3Hb no xapaxTepy cBoero TetieHlin Tpe6yeT AJIHTejIbH0r0 ne-
pHoRa Ha6alaurnift, He mellee HeCKOJIbK1IX JIeT. nOKa He IICTeK KOHTp0J1bHbIfi
epic B 3-5 JIeT, KK H3BeCTH0, HT JI,OCTaTO9H011 yBepetutocni B 344eKTI1B-
11OCTII TepaneBTIrteexoro meporipHRTHst. HexoTopbie ?xe cpopmbi, KK HanpH-
mep, pax NI0J1011HbIX Nce.ne3, naloT nocae panHxaabHbix onepatutil Hepeaxo
PeL1,11,1IMMI 11 II03,t1Hee. EMeCTe C Tem H3BeCTHO, 910 9aCT0Ta PeIIII,aIIBOB 311a-
tIIITeabH0 'cluriKaenn p(e no HcTetieHmi nepBoro rona nocae onepau,HH. Cae-
,a0BaTeAbH0, mem palibme MO)KHO obIJIO Hallam Ha6alaRetffin Haa nepBort rpyn-
nal 60J1b1MIX B YCJIOBIIHX CTP02000 KAUftlitleCK020 KORTPOAR, TCM cKopee
MO)KHO 6bIJI0 0>K11,/laTb pemeHHB Bonpoca o TepaneBTHueexort LIeHHOCTH
Me-
To.ua 6HoTeparuni paxa. 01IbIT 110Ka3a.1111p661MbHOCTb Taxoro pewemin:
1703TOdify Mb! Hmeem B HacTonatee BPeN151 BO3N10)KHOCTb nofweprHyTb xpH-
Tw-lecicomy aHaJ1113Y xatuumecxne Aamibie, nanytieHHbre Ha nepBbix sTanax
3KCHepriNleHTa:113H0-11P0H3BOACTBeHH0f1 pa6oTbi. ECTeCTBeHHO, ItTo Ha 3TOM
sTane HcanenoBaHHfi flUCI10 naloadrreabHbix c.nytweB HeBealixo. Ho pewalo-
LIMM HBJIHeTCH TOT (PaKT, tITO KJIIIHIltleCKHe maTepHaabi 1103BOJISHOT yeTaHo-
BliTb 3aKoHo.stepHocTit B TeLleinte paxoBoro npou,ecca, OTAUtilible OT Tex, KO-
Topple Ha6alonaloTcsr o6bputo. -aril 3aK0HONIepH0CT/1 nonnaloTcn, KaK 6y.ElleT
noxa3aHo a,aaee, axcnepumeHTaabHomy aHaaH3y 11 AaloT ocHoBy J1l,a,aJ1b-
nernueil pa3pa6oTxH meTo,Ra .6HoTepannu pan. 3101 OrIbIT
mucax He or 6brrb naitmeHeH 1-Ia6alonewisimil Han aetteHHem nepewmaio-
utuxcH onyxaneff aa6opaTopmalx I1J111 ,u,a-/xe Han aetieHtleNj 11X
CIIOHTaHHbIX onyxanefl, Hall6d.nee 6J1113KIIX 110 CBOHN1 CBOHCTBaM K paxy mum-
Bexa, noTomy tITO npo6aeNta 6HoTepamm npexae Bcero BKruotiaeT Bonpoc 0
npatenittecxoff geaecoo6pa3HoeTH 11C110j1b30BaH1151 3T010 cnoco6a B J1e9eHIIII
paxa tiezoBexa, B Tex ero cBoeo6pa3Hbix KOHKpeTHbIX Hp05113J1eHHHX, KOTOpbIe
Mb! Ha6aionaem TO-1113K0 y geaoBexa, co Bcemu OCO6eHHOCTSIMII, nplicyawmir
tte.noBet-lecKomy oprami3my.
He 11011,ile}KIIT CONIHeH1110, 9TO Ha xattecTBe K:111Hli4eCKIIX Ha6.110,ELeHlicl
110.11}KHb1 613I:111 OTpa311TbCH Bee caa6bie CTOpOlIbI npenapaTa H aeHeTBHTeabHo
0rpa3Haneb. Ho Ha ,KJlifliIitieCKFIX Ha6al0leminx Tax)xe oTpa3HaHcb H Bee
v.nytaueHHH, npoH3BeneHHbie c npenaparom. Hac He pa 3 nopax(a.no 3aKj110-
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
- -r
41.6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
db.
It
?P I
li`o ?
11,1
1 I '
136 01:PATII0E PA313IITHE OnN nr..10111.nix
time KJIIIHIIMICTOB 0 KatrecTse OT,/leabHbIX. MO114)IIKall,1111 ii.nii cepnii W1130TP11-
nainforo npenapaTB. CJIC,LI,YeT TIOXICPKHyTb, B K.nllnincy nocTyriaz IICK.M0-
MITeJIb110 npenapaT. 1-1a6.1no,Rall )Ke 3a pcmatireit 60JIblIbIX
na BBeaelnle npenapaTa, =tun cllcTemaTnnecKII coo6nta.na o cif mnTomax
cro AelicTBIllt Ha oprann3m 60J1bH01.0, 0 Tex KORKperHbIX OCO6e1MOCTFIX, KOTO-
pme o6pawazu Ha ce651 Bumaue npil o6leKTIIHnon perncTpaunn. Pa36op
K.nuiptecKnx AaHnbix npnBom.n }lac K aHa.nn3y sKcnepnmenTaabiro-npon3Boil-
cTBeHHoro nponecca, aHamt3y, npn KOTOpOM He pa3 nac yAllll.all.na 36811C11-
MOCTb luntutiecKoro AefICTBII51 OT MeTOXIKII H3roT0mennll npenapaTa.
Ha,ao etue yKa3aTb, trro ?Jura 113 OCHOMINX Tpy,a,HocTert KaninmecKnx Ira-
6.11!ueurt 3aKmotia.nacb B TOM, tITO 01-IH TIPOBOXIJIIICb, KaK 6bi.no ye yKa-
3ano, a OVIetICHHWX IIC.11061151X, OCHOBlia5I onacllocrb 1CpbblaCb 6 Fied0y116Te
acex aerpenym. Mb! cTapa.nncb B MIX pa3o6paTbcll if no mepe annepitmen-
TaabHoro nx pa3peweruill cTapa.uncb ycTpanllTb. H ia pa6oTa naxou.na no-
eTeneuo cHoe oTpmeHne B KJIlrHHKe. Halm mninnitiecKne ita6moxtem1ll no3-
:Ke, Bp511 JIM morau 6bI 1136e;KaTb NIHOrliX .11e340KTIIBIIbIX pe3y.nbTaToB.
M60 EH 0./.111H axcnepnmeHT He .Nio)KeTriojjeHirm KoHTpooll Bpemeu - Tpe6o-
mime, KoTopomy B COCTO5IMIII Y,ELOBjIeTBOPIITb TOTIbK0 Kmuninecxoe Ha6JII0Ae-
Hae. annepamen Ha -/KIIBOTII131X, He 4103I3OJIIIII 6bI nam cae.naTb
BbIBOJAa npocroro H STUMM, KoTopbni cpopmyanpoBair B pe3y.ubTaTe K./11MM-
CMIX Ha6JI10,WHIIII* ?PaKoBall orlyxo.lb lle.noBeKa no41. BJIIiIiiiICM NIIIKp0611 131X
tkaKTopoB no,a,BepraeTcH o6DaTnomy pannTino, He3aBIICHMO OT ee rucTore- ?
He3a?. Ha'KOHell, 1111 OAHU 3KcnepumeHT He ,naJI 6bi Ham 803M0)KHOCTII ce-
roAHH npeacTaBHTb Ha cyit Bpatle6Hofi 06LneCTBefillOCTII PLT1 KJIIIIIIineCKIIX Ha-
6.mor1.enun, TIOKa3bIBaIOLLUIX, tITO 3.noKatiecTBellHoe HoBoo6pa3oBanne RefIcT-
BIITeAblIO no,rtBepra.nocb ROJIHOII perpeccini If B peayAbTaTe 3Toro 6bIjI0 110-
cTarayTo KanunnecKoe BbI3210P013:IeHae.
B bl B 0 bl
1. lipti paKe y tianoBeKa, B OnyX0.7ISIX pa3Hoo6pa3Hoil npupo.nbr MOiKCT
6bITb BbI3BaH npouecc o6paTHoro pa3Bimill nyTem BBe.nemill B opralin3m 11111-
30TpanaHHOr0 npenapaTa, 0621a21.aroutero aHT116.nacTom11bINIII CB011CTBaMII.
2. KanHnnecKne Ha6mo.gemill noKa3a.nn o6paTHoe pa3uTne non BAH-
Eaaem wH3oTprInaHHoro npenapaTa c.ne,nyroutllx Bn,noB 3.noKanecTBenHbiX ony-
xanell n npe,ttpaKoBbix nopmemni tie.noBeKa:
1) paKa BepxHeil H ry6br,
2) paKa rarrocoBocr CB513KH,
3) paKa rpmfroil Nceaeabr,
4) H0B0o6pa3oBaHull TIPSTMOrfKilaIKfl C KJIMIFIneCKIINI ,nnarHo3om paKa IF
C rncTanorntrecKllm - azteHo1aT031{0r0 nomma,
5) paKa ninueBo,ga,
6) allrllocapKombr TeJla,
7) naMIJIiI51pHOR aJleHOMbI Tpy,Et}1011 ?Ke.ne3b1,
8) .nefiKon.naxmi CJIH3flCT0 HOJIOCTH pTa,
9) 6bmTpopacTyutect a21eHotjm6po1bi c perlloHapHbimn .nmajmy3.namn.
3. r1ICTOJIOrlineCK0e 1r3yt1eue noxa3a.no, trro o6paTHomy pannTtno no.a:
Beprazircb anoKanecTBeHHbre orr,Pxo.int n ripejtpaKoBble nopawelnill pa3./1inHon
npupoabt, pa3JIIIIIHOr0 crpoetttuz n pa3Hocl AOKWIl13121((111:
1) TIJIOCKOKJIeTOnfIbIrl paK,
2) TIJIOCKOKJIeTOLIFIbIrI oporoBeBarouHA paK,
3) 6a3mbHomneToturbirr pax,
4) aHrllocapKoma,
5) aileHoKapunHoma,
6) cKllpp,
.1EncTBIIll inimoTpunAnnoro Ill'EnAPATA
137
7) npeapaKoabte o6pa3oBaHHH:
nann.nallpHall menoma,
.neilKonzatani,
napaKepaTo3bt,
ruepKepaT03b1.
4. 06paTHoe pa3MITHe Momo 6bITb 13bI313aHO:
a) 13 nepButntom ollare onyxwm,
6) B meTacTa3ax,
B) B peull,n,llimoil 3JI0KaneCTBeHHO'1 onyxo./Ill.
5. 06paTHoe 3BI1T1fC paKoBoil onyxo.nn II npeLtpaKoBbix nopmennil
nponcxo,n,nT B npucyTcmint npenapaTa B oprann3me It nosTomy npeKpa-
utacTcH BmecTe c npeKpauteHmem InfbeKU,1111. OTclo,/ta BbiTeKaeT neo6xoAn-
NIOCTI) BBOAIITb npenapaT Henpepbmo BnpeAb 210 mamma lictie3HoBeHnsi
OHY-
XOJIH H OTAeJIbIlbIX 3.110Ka4eCTBeIlHbIX KJIeToK.
6. Him 3aBeputeHnom o6paTHom pa3BIITI111 340KatleCTBeIlHa51 onyxcob
6o.nee He peuummipoBa.na n He ;Lamm meTacTa3oB.
7. YmeHmuenHe onyxo.neBoil maCCM o6.ner4a.no narmuTe.nbHoe
6110TePaIIIIII II TI03BOASIJI0 6b1cTpee u.ocTnrHym 3aBepIlleHHOF0 o6paTHoro pa3-
1311111H 3.noxatiecTBeHHoft onyxcm.
8. Hpu ycoomin cncTeNtaTtillecKoro BBeaeull arrn6zacTomHoro 6Honpe-
napaTa onepaTnnoe BNIeWaTeJIbCTBO Nionno 6bITb orpammeHo Tia.nemiem
OnyX0.111 B npe,ue.lax nopmeHHoro Ha r.na3 yllacTKa, KI( 310 6b1.no noma3aHo
na psute c.nynaeB paxa rpy,RHoil xce.ne3bi.
9. 1-Ieo6xoximo nocTaBilTb 3w:tally 113ytleM151 nepeBoAa Heonepa6mbHbix
cpopm paKa B onepa6llambie, nootto6Ho Tomy, KK 310 Ha6.rno,Ranocb y
F. (cTp. 157).
10. KAtmuitecKtte npn3HaKll o6paTHoro pa3BHTtill onyxarni Bbipalliaaitcb
c.leayrouINIFI cHmnTomamll:
a) ocraHosKoll pocra onyxarni Ha cpoKll, pa3alltnioil OT
HCCKOJIbKIIX mecllueB ;to HeCKOJIbKIIX ..neT;
6) menbittentlem paamepoe OHYX04111, 410 perlicTpnpoBa.nocb npn ii3me-
peult cc;
B) anureAu3a1uee1 313661MOli noBepxHocTH, ycTaHamilBa.nocb ripn
NjIllantrecKom ocmorpe nopaelmoro ynacTKa;
vmenbuieHHem man iictre3HoBeHHeNt pernoHapHbix meTacTaTnllecKnx
Y3JI0B:
3aMeTHbIM If '3HatIllTeJIbIibINI y.nytnneHnem oftiero COCTOHHII51.
11. BbI3BaHHa5I MITI16JIaCTOMIII3IM 6no.norntiecKnm npenapaTom,
Bbtpallceuall perpeccull onyxwm Haxo,Itll.na no,RTBepllclleHHe B immeme-
111111 micTozormllecKoil KapTubT nopmeHtill. II3MeMIJIaCb cTpyKTypa onyxo-
yMeHbInaJI0Cb tnino MHT030B, Hapywancll pll,tr, xapaKTepHbix moptpo.no-
rntrecKirx HpHdHaKoB, npucyrunx 3.noKallecTBeHHoil meTKe. AHammy
STI1X 113-
Mel! elihlil nocutuella c.nellyiotu,all man 3T011 KurH.
12. 06paTHoe .pa3BHTne onyxann B 0,RMIX c.nytiallx HOCHJI0 3aBeplueublil
xapaKTep, ?Kouta npouecc perpeccu 3aKaHllllBa.ncll ckopupoBaHnem py6ua
Ha mecTe panee pacrignarainueficll onyxann. B ,upyrux ?Ice czytpllx npir
Toil
meToxiKe, KoTopall npllmeHllzacb B onlicaHHbix Ha6.11!0,11.eHllllx, y,ttaBa.nocb
BbI3BaTb Bpemeuyio perpeccHro,, KoTopall 3aTem ycTyna.na mecTo BHOBb
BO3HRICaBUIeMy aKTIIBHOMy pocTy OHYX0JIII. OCTaeTCH HellcHoil nputunta ocTa-
11013KII o6paTHoro pa3BHTllst onyxwm B Tamix czynallx H HacTyruleHnst petlyaK-
TepHoft pea-Kull. B tracTit c.nynaes HecomHeHHylo pOJIb Hrpa.no KaneCTBO npH-
meHeHHoro npenapaTa H Hepa3pa6oTaHHocTb meTo,anKll ero EpHmeHemill.
OioraKo He ITOAJIeNCIIT COMHeHMO TOT 4MKT, 410 Cpall 3JI0KatleCTBelMbIX HOBO-
o6pa3oBauti cyutecnyeT paaattituctsz cTeneHb IlYBCTBHTeAbHOCTH K
namiomy cimKTopy.
rof
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
133
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
OrWATHOE PAJBUTHE 3AOKAHECTBEHHUX OHYX03EH HEMHIEKA H
13. 110TIONUITeAbHbIfi 344eKT 6bra AocTurnyT Hecbma MaJIbIMII )1,03aMll
allTno.nacromHoro semema: ..nerKo 110ACHIITaTb, HTO npn Innen= B opra-
HIBNI BBOXIJIIICb ea.11.11b1 aKTIIBH0r0 HeatecTsa unmoTpunaHHoll KJIeTKII II B
pn,le cap-Ian 3moKatiecTHeHHan onyxo.nb Hall ymeHbwa.nacb Han pa3-
pvina.nacb Ao KoHua, OCTaB.1151H noc.ne ce651 py6eu.
14. acTemantiecKoe lorre.ribHoe Ha npoTH)Keium pua JIT me,kenne
B opramm unmoTpnnaHHoro npenapaTa B A03aX Ao 5000 ez,HHHH Ha IIIrbeK-
HHIO He oKa3bma.io naTo.nornilecKoro AeficT31!1 Ha BurpeHHHe opraubr He
2b13b1Ba40 HI! opraHnilecKoro, H11 4yHKI.U1011aJIbH0r0 HX nopa)KeHHH:
a) 60JIbHbIe paKom, H c.lytzaHx, Kora Hsedr_teHHe npenapaTa AaBa.no HO-
J10/(IITejIbIlbIrl pe3yobTaT, 3HatIIITeJ1b110 npll6as.nsian B Bece ? OT 1-2 Ao
10-12 xu.norpamm B TeneHHe nepuoaa mrbentufi;
6) HccaeaoHaHne KposH noKa3bma.no no.nHoe coxpaHeHHe (1)H3H0.n0rline-
cpyHKunll KpoHeTHopublx opraHos: cl)opmy.na icpoHn ocTaBa.nach 6e3 xa-
KHx-an6o npn3Ha1os naTo.ionmecKoro xapawrepa; peaKuHR oce,RaHHH 31311-
TpOIHITOB, npoTexasulaH npH AerIcTsim npenapaTa 6o.nee 6brupo, JIerIK011,11T03,
130 'Bpemsi nwbeKunil so3pacTasunffl, a TaioKe HeKoTopEde Kane6aHH5I B COCT051-
111111 KpacHoft wpm!, HaomoAasumecn B nepHo.ae HirbeKunii, HO OKOHtla111111
Kvpca, KaKort 6bI HAIITaTIbHOCTII OH HI! 6bIjI, ? BOCCTaHaBAIIBaJIIIC13 COCTOH-
111151, csoficTseHHoro ..u.aHHomy 11111I,IIBILayyMy 13 ero 110pMa.IIb110N1 4m3Ho.norn-
4eCK0NI (PyliK13,110H1Ip0BaH1111;
B) cucTemaTntiecKoe Hcc.ne,RosaHHe motm TIOKa3bIBaJI0 nopma.nbHylo 14)yHK-
unt0 noLtex Ha mem npoTH}KeHHH Kypca nwbeKunct;
r) HHyrpeHHHe opraHN, He nopmeHHbie paKOBbIN1 npougccom ? negenb,
nowth. Tpawr, KOCTHO-MbILLIeHHbIci annapaT, Heiman
cucTema H ncnxiltiecKaH cckepa ocTasaimcb Henospe)K,ReHHEmn ii ne npons-
.151.111 naroaormecKnx IlpII3HaK0B B ajIIITeabHbIX II TIOBTOpHEIX xypcax IfirbeK-
U1111 Ha npoTmemill pH,la
npn HaJIIIHIIII y 60.1bHbIX paKom xpommecKnx C011yTCT6y1011411X nopa-
HieHnii, KaK-TO: muoKap,ano,aHcTpoqm, opraHntiecKnx nopmeindi K.nanaHoH
cepaua. KomneHcHposaHHbix H C He21,OCTaTOHHOCTbI0 1-rf cTeneHH, xpoHntiecKux
racrpo-Komrros, renaTo-xo.neunTHTos, o6ocrpettut7 ne tta6./uoaanoco, ire-
cmorpH Ha AzurreabHoe sseaeHHe wmorpHnatnioro npenapaTa B opraHH3m 113
npoTHH:eHnn mHornx mecHues H .aaxce HeCK0J113K1rX .neT;
e) 6HoxnNumecKoe Hccoe.aosaHHe Kpomi He o6HappKnsa.no IIp113HaKOB
nospeKuseHnil opraHH3ma, CBH3aHHbIX C sHeAeHnem unnoTpunanHoro npc-
napara.
15. Ha6.inoaeHlle noKa3bisaeT, HT? perpeccufi 3.1oKa4ecT3eHHoil onyxo.m,
Hai; Jr npeapaKosbix nopmeHlifi, Haxoxmacb B HOCTOHHHOil 3aKoHomepHoil
crin3u c HachnueHHem oprammma aHTI16.71aCTOMTIOCI (1)paKHHefi unmurpnnaHym.
3Ta CBF13b supaiKa.nach He TOJIbK0 B TOM, "ITO npeKpauteHHe nwbeKuHil BbI3b1-
Ba.10 ocTaHosKy perpeccnu, HO TamKe H B TOM 13.11151HIIII, KoTopoe OKa3breaJI
IlpeTIapaT B 3a1311CHNIOCTII OT csoero KaHecTsa 11 "1,0311p0BKII: peepecctuo C110-
CODe1-1 6b1.1 6b13b160Tb T0.1bK0 TOT npena par U3 tuit3orpunanym, 6 KOTOpall CO-
xpanit.ica attr1z6.dacTamnb1a ckaKrop c 111-l3eliC0.41 aKT1161-10C7'I1 tte Hume rpex,
npu tipumettenutt na Pally IIH'beK1(111D (303 6 200-300 pa3 npeaocxoasittiux ao-
31)1. KOTOpble 6b13b181110T peepecctuo capKombt KpoKepa y 6e_zotx Atbutuni.
16. Ilpn co6.Tuo,ReHHH yKa3aHHbIX OCI-106HblX Tpe6osamdi, OT}IOCHLIOIXCH:
a) K IlHaeKCy aKTIIBHOCTII awTH6aacromHoro uni3oTpunamoro npenapaTa,
6) .3o3am, B) ClICTeMaTIIHHOCTII ii HenpepusaemocTu Kvpca nwbeKuHrf.?
KaHueporepanesTntlecKHfi 3clxbewr, 01111CaHHb1ii B 3T011 KEHre ?3aKoHomepHo
noeropuit.
j\NAMOMEPHOCTH AUCTIHIN numTmummoro UPEHWATA
139
*
BucKasaHHble 3)I,eCb co06paxieHHH HaxoAHT cHoe o6ocHoHaHne 11 AaJ1b-
neihnee panwrne B 110CJIe,ay101.1.111X 1)a3Ae.nax K1111111, 110C1351111e11HbIX IHITOJI0-
ritgect:omy H micTo.nonmecKomy mammy mmeHeHHil 3.noKatiemenHbix ony-
XOnerf noit HAHHHHem 61!oTeparnm, a Taw,Ke 3KcnepHmeHTam, xoTopbie crpe-
NISITCH BCKpbITb mexammm AeficT3HH inH3oTpHnaHHoro alITH6HOTHKa Ha paxo-
Male
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
=
111101144...
It
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CiA-RDP81-01043R001900080003-6
140 l'IICTO:101'11HECIOIE If RIITO:101411HECIiIIE II3MEIIEUIII B 3J101tAtIECT
\,7 Ilacm
IIICTOJI0FHEIECKHE H LI,HTOJIOrH4ECKHE H3MEHEHHSI
B 3J10KA4ECTBEHHIAX 0.11YX0J15IX, JIELIEHHbIX
WH3OTPHIIAHHbIM IIPErIAPATOM
Haw TIICTOJIONILIeCKIIII ,afraall3 II BbITCKaIOW,HC H3 Hero 13b1BO:kb1 6a311-
pytoTcn Ha Jusyx OCHOBHbIX rpyrmax Ha6.rno,Renstil:
a) namenesum B onyxo.nnx HeimHeim nofi, 134111111111eNI wisaoTpssnantsoro npe-
napaTa;
6) names-let-mu B onyxo.nux annepumeHTa.abHbrx iKIIBOTHbIX no BJ11151111101
6HoTepansut.
He ciseAyeT npeyHemstnsuaTb 1303MO}KHOCTII smaccisHecKoro rucTofiorntse-
cKoro, T. e. cTporo moptpozorntsecKoro AieTua 13 ou,eHKe cAussroH, nponcxo-
fiHuHix B onyxoonx no B.1111HHIICM xaKoro-ast6o TepanerrrnHecKoro arenTa,
CCM! 3111 nameHensiss HaX0J1,51TCH B CTaalISIX. TO.1bK0 B TeX c.nyttaHx,
rfie mouume B03,11,e11CTBIIe Ha onyxo.nb npisHofinT K onenb peasurm 061WIM Niop-
ckozormecicam names-leftism', rucTozor .41031Cer yreepoicaaTb. Bo ucex ocra.nb-
MAX. czyttaux r.ucTo.nor a0112/CeH y6excdarb, 110./1b3)*THCb II ucemn rips!-
Moro Ha6.nroAeHHH it uefieHanpanaeHHbtx. aKcnepsimenTon.
3TO nozo}KeHne 061SICH51eTCY1 Tem, IsTo:
BO-nepubsx, B J11060fi onyxann Mbl BHAIIM .K.IfeTKII B cammx paa.rnstntbsx CO-
CT051111151X, HatinHaH OT aKTHBHO paCT371.1411X II paamHo)KasonutxcH ,Lso KJIeTOK,
>K11311e,Re5ITeJIbliOCTb KOTOpbIX aaTyxaeT n KoTopbse HaxofisiTcH na paanbtx. cTa-
,EIHRX Aerenepaunn 11 rst6east,--ux Ko.nuttecTuo mHoroo6pa3110 napbsspyeT B
a.noKanecTseHubtx onyxo.nnx;
BO-BTOpbIX, rsicTanormecKass KapTisHa mo)KeT 6bITb pa.3111111Ha B Pa3HbIX
MecTax 3.noKattecTHeHHo5'i onyxwm is Tem o.nee B paaattLutbie (Imam ee paa-
BUHL
Bce aTO AocTaTonno 06W,e113BeCT110. F103TONIy Tpy,nHocTis peweittift 110-
cTaB.neHlio1i inpo6.nemb1 AocTaTonHo HeonscH. Ofi,Haxo coneTaHue mopcpanorst-
necKoro meTo.ga c rsicTotimiaHanorlitsecKilm n mnKpoxnmsniecKstm Nlo)KeT B 3Ha-
nliTe/IbHOrI mepe 110BbICHTb pe3yJIbTaTIIBHOCTb HCCJICA0BaH115.1 rips! yCJI0B1111, tITO
MIIKpocKommecialii alia.nua 11p0B0/1,1ITCSI He OTOpBaHHO OT 3KcnepHmeHTa"u KJIII-
IffItleCKOF0 011bITa, a KaK six HepaapbunfaH nacTb. B 3TOM n.naste MB! H 11b1Ta-
J111Cb BeCTII CB011 IICCJIU1,0BaH1151.
KaK MbI pKe cKa3a.rns, Hce Tpy,aHocTH nicTo.norntlecKoro ii umTozorsine-
cKoro allasnma OTHOCHTCH K Hattaohnomy nepstoay npouecca o6paTHoro pa3-
BUHR 011yX0111I, Kora 06b19110 npHmemzemble MeT0,11113I oKpawtsuamin 6eccu.nb-
Hbr BbIYIBIlTb a 60.11b11111HCTB0 rsicToxilmwtecKHx. peaKunsi OICa3b1-
BaeTc51 mazo rtoKaaaTeabHbrmH. Te xe no.no)KeHisH BbICOKOil Mepe OTHOCSITCH
If K noc..ne,aysoumm tigaaam, KorfAa npoLteccbs paapyinemsH paKoHoll TKa1111
TOJIbK0 13 dua6oft mepe npeHamspyloT npoileccamH THRINHOW pocTa it paa-
BIITIIsI onyxo..nesoil TKams H Kora 011yX0JIb rspeAcTaanneT eu.ke m0313111Cy 113
K.TIeTOK, )1{11311b KOTOpbIX paannuaeTcH B pa3JIMIHbIX, no,attac AssameTpa.nbno
17p0THBOITOJIMKHbIX Har1paBJ1eH1151X.
1-1T06bI 110 B03M0)KHOCTII 060CHO13aTb BbIBO,RbI 113 aHaznaa Toro maTepu-
KoTopbscs Ham Aaua.nx H KaHHHKa H aKcnepHmenT, MEI yusTbsua.nis, nomismo
o6uterncTonornnec11x nameHemul, c.neAytoume momeHTbs:
13E11111AX 011WX0:151X, IIPEIIAPATOM
141
1) peawraaaoe pa3BIITIte commurranbaoil
2) maKpotparaabstyso peaKunto, a TaloKe zumcpowiTapayio is mossosusTap-
Hp? (rsicTouuTapHyso) peamtwo;
3). Kapsto.normecithe cAaHrts:
a) H3MeHenisi THMOHyMell110B0f1 KIIC.110Tb1,
6) cfi,unrn nteptio-sutpbswxoubsx OTHOLlIeHHil,
13) paameptibte nameneHHH Hfisep,
r) H3MelfeBBSI mHToTHnecKoro muleKca;
4) nitepHo-HATon.naamaTunecKste exilic's (no Komypo): Bb151BJICIIIIC cTa-
pesow,ux it 110131MKACHHbIX paxoabtx KJICTOK;
5) H3Mellelii151 p1160HyKJIeIIHOB0il KIICJI0TbI, Hameilwero (1)awropa pocTa
II paamsto)KeHuss. luseTost; .0
6) 113Me1e111151 JIIITIOH110r0 II xonecTepinsoaoro noKa3aTe.tus paKOBbIX
K.neToK;
B KattecTue BCHOMOraTeJlblibIX rucToxismistiecKnx peaKunil 6bIJIII HCII0J1b-
30BaHbI peato.uns; 7) Ha ramorett; 8) BHTaMIIH C; 9) OKCII,3,a3b1, nepoKcis-
fi,aabt, oKcuRopeAyKaabt, cymutHoilerufitpaabt, 10) aprintssu (rHcTosibt);
1 1 ) rmoTaTHoss.
HaKoHea, B u.e.nom psule c.nytiaea npossaBoAnfiacb naamtmeTpun pacTy-
nusx Is AereHeionpysouusx yHacTscou B onyxo.rmx. ConeTasuse nicTanorsinecKnx,
H u,wro.norntsecKHx MeT0A0B /1.0113KHO 6b1.10 1103B0.5111Tb Ham
ytecTb He TO.111,K0 stan6o.nee pannse 113NICHe111151 onyxofieuoil TKaHH, sso is, B
maKoil-To mepe, npoHHKHyTb B mexamsam AeficTrmin wis3oTptinaHstor0 'Tema-
paTa Ha KJIeTKII 3.110KatleCTI3e1IfibIX Hou006pa3oHannfi.
HABJ11OPEHI451 HAP, KJIHHIPIECKUM MATEPHAJ1OM
fl,n31 113)711eHH11! rucTo.normecKsix H wiTo.norunecKstx st3melleHal anoxatie-
CTBeHHMX onyxo.nefs meaoHexa no u.nusnulem 6noTepanust Mb! N10r.n11 sicno.nb-
30BaTb 'maTepriaa, nanynemibsil OT 60J1bHbIX B paaammbsx CTa,E1,13FIX pa3BIITHR
paKoHoro npougcca:
a. B nepHoxt, Kora .neneHue wHaoTplinaHHum npenapaTom He AaBa.no
06'beKTIIBHO perncTpHpyemoro Tepaneamecxoro ecixpexTa, 311160 3TOT 9C1)(13eKT
Shin KpaTKoapemesumsm, Hc...neAcTuste nem 60.11bHbIe 6b1ats onepnpoaambs pa,sus-
Ka.nbsto.
6. B cTamin ocTatiostzetunocA pocra, Koma onyxofib, paHee nporpec-
CHBHO yHanutnasarnuancn, npexparaa.na cuoe ascriumoe paaHHTHe ii nepexoJus.na
KaK 6121 B cTaluno cHoeo6pa3Horo paaHouecHn, ins pocTa 011yX0.11H, 1fH ee pe-
rpeccms. Ha Ha6.11mes1nct Mb! B11JI.JI11, (ITO TaKoe COCTOHHHe, CO3-
aaitHoe unt3orpnnaHHoro npenapaTa, mom? 6mTb Hecbma A.T1H-
TeJlbHbINI.
B. B cTafinn o6partioeo pa3etintR, BbI3BalHHOr0 ./IefICTBIleM unnoTpllnaH-
nor? npenapaTa, Ha paltustuthsx aranax paapyweHHH 3J10KaileCTBel1110c1 TKaHH
pereHepauHts Hopma.nbnoil_TKams.
A. LI, FiT040flitleCKliii aHaJI113 onyxoners 60.nbubsx, y KOTOpbIX 110.1101KHTC.RbHbal
34npeKT aetsesisssi K.11111114CK11 He 6131.11 ycTaHoa.ness HMI He 6bia XOCTaTOHHO
"HCHO abipalKeH
MbI pewHzu cHatia.na noaueprHyTb unTo.normsecKomy anaaHay onyxofist
7011 11,0B0J1b110 3Hatime.abli0il rpynnbt 60J1bHblX, B ou,esuce xoTopbsx CTOJ1b
traCTo npllx0,IIATCH 3-lpn6eram K fle,13,0CTaT0t1110 TOHHI3IM 11 pacnobsaisaTbsm ()ripe-
.aefietuutm, KaK stanpnmep, ?aa'aep>KKa B ,pocTe onyxo.Tap, ?apemeHHass ocTa-
Holm 3 pocTe?onyxo.rus?, T. XL
H T. II. M313eCTHO, kaK mHoro cy6beKTHuHoro BHOCIITCH, B0J113110 11 11e130.11bH0
Hcc.nefi,ouaTe.nem npH nwto6Hbtx ones-maxis KaK ma.no TaKlie onpaanelnin
rnrw Annroved for Release 2013/04/12 : CIA-RD1-
P801043R001900080003-6
'
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
VP?
142
l'IICTO.TIOMPIFCIOIE II IIIITO:lorlItIECKIIE B
Amur turraTemo 060CHOBaIlHbIX Ha,ae)K,tt 11 cKo.nb milord 6yi1HT cnpaHeivnifibtx
comlleHnfi. nosTomy 6bura nocTaH.nella 3mana HalITH cpe/111 milornx meToitoa
unTanorun TaKite, KOTOpb1e 6b1J111 6b1 OTHOCHTO.I1b110 JierKo BbIII0J11111111b1 H 110-
3B0J151JIII 6b1 ,RaTb oOvelatiattylo otietwy 3cIm1)e1(ra =m1131151 wir3oTplinannoro
npenapaTa Ha moKattecTHemtble onyxann. 0/1.nn Toro, trro6b1 ouenitTb npo-
nponcxo,nisnune 13 onyxansix no ,u,I3JIIUIIII1eM unt3oTplinalmoro npena-
paTa, Hail? yaeCTb, t1TO npeHpaw,eHne Hopmanblion lumina! B moKanecTHeit-
IIVIO C13513aHO C nny6oKilmn 611anornnecKllmn 113MOHOH1151111 II pma ee CBOrICTII,
113 KoTopbIX ,HeKuropme OTHOCIITOJIb110 .nerKo HomalOTCH yneTy
CKHMII Menvia'Am.
MTorn MI10111X HCCJIOROBall 11f1 110 611o.norini paKOBbIX 1(.11OTOK 1103B0.151i01
CtIIITaTb, tITO mannrH113aultn HOOTOK 11aX0,1111T CB oTpa?KeHne B HameHeinin
onpeite.neHHoro KommeKca unTo,nornnecknx 11 u,trro4n3HonornnecKnx HoHa3a-
Te.neil: 1) B yHennnennn pa3mepoH a Hapna6n.nbnocT11 Hep; 2) B runep-
Tpockint Hammel( 11 HapyweHnn panteptnaix Holleplio-rutpbuuKoHbix OTHOWOHTI ;
3) B pe3Hom n03pacTa11H11 intc.na MIIT030B. HOT 3.0CT/IT0tIlIbIX ocnoHalinfi
Tam, tITO Kaxutbni 113 nepennc.nemibtx np113HamoH, B351TbIr1 B OTAO.11b110CTI!,
213J1HOTCH crteuntimnecKnm ,D,J1513.n01(anecTHennbix K.TIOTOK, oatiaKo Hce Tpn np113-
HaKa, B cHoefl coHoHynHocTn, TIO3BOJI SHOT Ha6.moitaTenio, KK 3T0 6y/teT noKa-
3aHo Aa.nee, ytII1TbIBaTb tzepaottatia.ibuble caatteit B 6110.710rIltIOCKIIX CBOCICTRaX
paKOBbIX KJIOTOK. HCX0,1ka 113 3TIIX coo6pmenntl, 6bi.no npe,napinniTo mule-
,noHaltne onyxo.nerr 19 60.71b11131X, KOTOpble nennnlicb unmoTplinannbim npria-
paTom 11 13 OTHOLLIOHIIII KOTOplAX, no MHOH1110 ire 6buto ,140CIP-
T04H0 BbIlIeCT11 oKoHnaTe.nbHoe peweHne ? oKa3an .1111 11111.3)-
Timinambiti npenapaT B cnynasix TO 11011 inroe Ha 3noxatie-
cTseHHy10 onyxo.ab. 4To6bi OTBOTI1Tb 3101 sonpoc Heo6xo,1Lnmo paccmoTperb
nTorn Hil>Kenplumanmbix Ha6mo,neHnil.
1. BOJIbIlaiI K-air. cIpn nocTyn.neHnu 13 1(.11111111(y: B Hepxuem HappKnom
KHa,npaHTe .neHoft rpy.nHoii ?Ke.ne3Bi ,n,Ha 11.TIOTHbIX o6pa3oHannsi 2,5 X 2,0 a
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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154
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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parait 310011T Haminan paimtue K.1111-11111eCKII yffanaaAtioaeditoeo !Rome/tun.
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Nile Ha6.110AeHIIH M0r.T111 6b1 AaTb Han6o.nee Liencoe npeAcTan.nernie o 3aKoHo-
mepHocTfix peaKunn 3.10KalleCTBeHHbIX K.71eTOK Ha 6110TeparIeBT1111eCK0e B03-
,1eficTme. Ho HaKon.neHHe 3Toro NtaTepna.na B K.1111111Ke HaTa.rnma.nocb Ha
113BeCTlibIe TpyAHOCTII. OHli 3aK.711011a.111Cb B c.neAyloutem. Ec.an onyxo.lb noa-
nepra.nacb B npouecce 6HoTepannit o6paTHomy panirrino, TO, ecTecTneHHo.
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Ha Niecre 6bunuei1 onyxo.111, 663 KaKIIX 6b1 TO HI! 6131.10 OCTaTKOB 3.noxat1ecTrien-
Horo nopmemin, 11.111 B snAe .ratun? 6eccTpyKTypHbix C.T1e2L0B era pacnaAa.
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unt3oTpnnaHHoro npenapaTa (ckuro 81, pnc. XVI); 11a6moAenne 44.
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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na6moReHim mom? Haytnto 01.1,e1111Tb TOAbRO 6 C0601Cy111-10CTII C Aa..rnanenunimil
rucTozoriltiecKilmii npose,u,eHimmit Km( Ha ,ICITHHIIIIKKOM Ma-
Tepiraze, Tax H Ha maTepira.ne cnonTaHHux.11 nepesHBaioutunst onyxwen .na-
6opaTopribix )1CHBOTI1b1X. nO3T0NIV He 6y,r1.em cnetunTb C 1313IBO,aaMII, a cTaHem
Tepne.atmo tmyTtaTb c06paHlibre 11a6.inoaelnifi.
2. BOAblia31 r-Ha, 56 ACT. flocTvnuJia B KJIIIHIIKY 21 Masi C anarHo3om:
paK Aecoti epyanot7 orce)ze3bt III maw& Pa3mepb1 orryxoan 11.0 aelleHHH:
7 X 5,5 X 6 cit; onyxoab xpgateBoil KOHCIIC1'e111.111II. B 110,4M131Wel1H011 BIM-
-11111C AHa onyxo.Trenix y3.ia. 25 Ntasi npon3BeiaeHa 6Honclur ii HatiaTo zetle-
Kycoltex onyxo.ini, yz.a.neHHbnl npu 6nonclai, (5131.11 u3yEtex npocl). Pa-
nonopTom, KoTopmfi .rtaa czemnoutee 3ax.rnotteHne: licczeRosamiii ylta-
?Tierrnoil onyxarnt 061!appKeHa KapTima co.matioaO paKa. 06Happxelibi pe3xo
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
. 411A
158
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
11.ICT0.10111tIECHIIE II turroaormEckm: 113NIEHEIIIIH 13 3.1101iAtIEC1
noallmopcimbre 1LIefiK11paKOMAX KJIeTOK, 3aamennble B BOJIOKIIIICTOil crpome.
o6utem, caa6o pannToil, trro npnottaer paKy xapaKTep mo3rom11oro. B
icteTKax mHoro NIIIT030B. BCTpe1IHIOTCH B 60JIbWOM KOJTIPleCTI3e o6umplIbie
yttacnat pacnma onyxcon>>. K onucaluno, ,Raintomy npotp. $1. JI. Pano-
nopTom, Mb! moxcem ,L1.06aBIITb wieor.tylow,ee: rpamm,bt paKoBbtx KJICTOK HeTKO
He Slapa oKpyrable, CBeTJIbIe, 6aabtaux paaitepoe c xpyitubmitt sapbua-
Kama. Cpemnal pa3mep %pa paBeti 34,3 naannmeTpimecKnx e.rtintnn.
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PIIC. XVIII. Cpanitelitte pa3mepon slaep pm:mon onyxosilt 6OibIIOi F. 4,(3, (66)
ii noc.ie octieinui (701 ii ) no.o. wimorplinainibm npenaparom
npoitammo 3riaturre.tibrioe ymenbuiemic pa3mepon Mau.
011yX0Ab 6bicrpo pacrytaaR. Ha 100 noaeil 3pemm
103013, 113 MIX B
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TeabH0-TKaltHbINIll npocaoliKamn COU,111111Tellblian TICHI1b 011yX0.111 C0,71,epiliHT
B OCHOBHOM (l)116po6aacTimecKne 3.11e:MeHTbl, nemHoro 114CTI1011,11TOB. B oKpy-
:Kammer( coeaumTeabHoti TIQH11? KJIeTKII pa3,apa)KeHnu BlIe60.1b1110M Komi-
tiecrBe. B onyxciaeBoil TKaffit mem-awl 6oabunie yitacialt HeKpo3a. KpoBeHoc-
HbIX cocy,ttoB Nia.Ho. llocae 25 turbeKunii npenapaTa (31 330 exHinu)
25 mous' npo113seitena paamKaabHau onepauHu ? yAaaeime aeBoil rpya-
not' ?Keaesbr H JIIIM(DaT1111eCKIIX y3.110B 113 no,s,mbnuetmofi Bria,umrbl. ripir tlICTO-
mrimecKom HccamoBaHHH ya,aaelmoil onyxoint 06Hapy)KeHa o6uta5! KapTima
coaugHoro paKa, HO B OTJ1111-111e OT nepsoa 6tIoncult, CO 3HatillT6AbablAta
ytlaCT-
K.C7.1111 arporPutt palcocoa TICatal, COCTORlallAllt 113 TO11K080.1101CHUCT0a CTp0.11b1,
6oearoa sbrrsulynoui upamit, B xoTopoil paccesuibt B .11e6011bIllOM KOJI1111eCTI3e
aTpotimpoBaHmpie paKompie KaeTKH. B paKoBbix smecmax K.neTxtr pacnoamKeubt
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0113?XoJNIX, IIPE1IAPATN31
159
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/MC 113AWHef11151 ICACTOK, CpCall KOTOpb1X AIKOZO 6b1T.flayrblX, (1TO nano-
.ittataeT Kapruay Ate3euxuAtonRacrittat 31111TeAUR. 061rapy)KeHbI aTunktilecKne
N:11T03bi 1-1060Ab1110.11 KOAllifeCT66 (3aKaloge1uie npotti. SI. JI. PanonopTa).
K ormcamno, ca,eaannoNty npo(1). 51. JI. PanonopTom, MO)K110 AO6H1311Tb,
tITO Hamm ycTaHounellbi B onyxoau 60J1bHOi1 r. caelvimune nsmenemm, nponc-
'Heim-re nocze npoBeAeHHoro Kypca aegemln wH3orptinaHHbrm npenapaTom.
411C.110 MIIT030B B onyxoneBoil TKHHII pewco CHU3UAOCb. Ha 100 noneil
spemm ycTanoBaell 41 MIIT03, 113 MIX B craaini:
npocim3b1 0
meTa4ia3bi 34
anacila3b1 6
Te.tiocila3bi
Taiiii o6pa3o1, ?111C...110 NIIIT03013 CH11311A0Cb B 6,4 pa3a.
Pasmepbr mep 3IIH1111Te.11bH0 113Me1111.1111Cb: Cpe/W1111 pa3mep smep VNIeilb-
IIIIIJICH AO 23,4 (3 noanumeTpimecKnx eamitimax). OTHoweHne pa3mepos
sutep, B311TbIX aegemiu, K mpam, B351TbIM nocae aetieHmi, palm? ?1,42:
npousowao cyttiecreeanoe meabuleaue Raep. 0,71,H013pemeH-Ho 113NIeHmach II
cTpyKTypa mep. )Io aetiemm mapa Ha npenapaTax caeTable c tcpynabutil Ra-
pbautcamu (caac-iwa upbmiKa), nocae aetteHuu HApa oKpaunmaiong no-
unomy remaTonnalmom (6oaee Temuo), a aapbutucti BO Ninornx sia,pax OTCVT-
CTI3y1OT iI.T11i KC 01Iellb MaJI131.
I'L3MelreH 1151 B onyxoan He orpaHntniBmong pe3Kum cHH:KeHilem tmcaa
MIIT030B II yN1011131110111101 pa3mep0B Ii cTpyKTypb1 mep. H3.1161-111A0Cb a 011CTO-
.70e1niectcoe crpoetate onyxaut: BO muorilx. mecTax paKOBbIe Komi1 pacnoao-
pbixao, pa3po3HenHo, 1IeTKO orpammelmo Apyr OT Apyra, KzeTot-mbre
xopoulo BI1,1111b1 (cimr. 89, 90).
143meiniancb He TO:IbK0 paKOBbIe KleTKII, HO II TKallb CTp0MbI: coeanHu-
TeabtraH TKailb coRep(IIT mHoro rIICTOWITOB, JIHM113011,11T013, II KJIeTOK pa31pa-
)Kemm. THKFINI o6pa3om B aetrelmoil onyxciam 6oabHoll F. NIO;KHO yCTHHOBliTb
ueabill Nut cytaecreemibtx a 06ZeKT116H0 peaucTpupyedubtx u3Ateneaua. CO:10-
CTHBACHIle ItByx rucToaorimecKnx allaan3oB, a?o 11 nocne .11eHe1111H, TIOKH3b1-
Baer, IITO noc.re .netieHnu Ha6.Ino,r_taercB:
1. Flousaenne 3llammeabilbix yi-laCTKOB aTpotimil paKoBorr
2. IlouBaemie AncicomnaeKcaulm paKoBort TICH1111? SIBJIeHHe, C KOTOpbIM
ogeHb tiacTo BCTpeTIIMCH B J1e11e11HbIX CTIOHTHHHbIX onyxarmx M0.1101IHbIX
iEe.T1e3 }KIIBOTIIbIX.
3. YNICI1bIlICIIIIC pa3mepois Ba,ep paKOBbIX EJIeTOK: ymeHmuemie t-mcaa II
pa3mepoB nx u,ttpbnueK; u3me1-fenne oKpaunmaemocTil staep.
4. YmenbuieHne tlIICJla MIIT030B ? NIOMeHT, KoTopbal 3acay?K1IBaeT cepb-
e3Horo BIIIIMHH1111.
5. 1/13meneHne KJICTOI11101-0 cocTaBa COe.T1111111Te.11bH0-TKHIIHOil cTpombl
3HaturreabHoe y-BealmeHne 1111caa rIICT1101111TOB, nouBaeHlle 3ameTH0ro Komi-
liccTsa JIIINH13011,IITOB 11 KJICTOK pampa)KeHuu.
6. 51Baeune npouecca me3etimmani3aunn paKoBort mann; 311aate.HHe
ioro npouecca ? KaK Item noaownTeabHofl peaKu,m4 I1O,L Baimmem sKcne-
pumenTaabliblX B03,aefiCTB1111? HeitaBH0 cHoBa noultepicHyan: ,/1so6poBoab-
cKau-3tmaa,cKast n HexopmueBa (1947): 3T0T npou,ecc me3eHxumaTn3aunir
?I303111IKaeT B tHICTO-11e011J1HCTIFICCICOilTICaHH, 6e3 CBSI3Ii CO CTpON1011
Ii Beam- K 6onee nan MeHee pacnpocTpaHeitHomy samemeHmo paK03011 TImene31IcTaH cpopma paKa, pacTymero B (1)116po3Holi
ori-lone Komoro noxpoBa?. 15 VII 1947 r. npouneueHa 611onclisi: nccenell
yllacToK Ko>KH C AByNISI BHyTp11K0NKHbINI, He npH6eraH K pammanbHoil onepaium, npoHasecTH pe3eKII,III0 HOBO-
o6pa3oBaHlig, He yilaJ75151 BCCil manotmoil n(ene3bi, HU JIIIM4)0y3.710B n .511N11110-
nyTert.
floupo6Hbici aHan13 yAaneHHoil onyxwm 6bin npoH3seeH naTo.noro-aHa-
TOMOM KIICBCKOTO 011K0.110T1ItleCKOTO IIHCTIITyTa npo4). IIIBe,rmonoil-Paule, J110-
0e3Ho npen,ocTaminweil Ham cBoe 3amn10neHne, KoTopoe MbI npuBonsHm H opu.
mane (Kypcnn BbIlieJfeH HaNni). ?Onyxonb 6enoro useTa, TBepAoil ?KOHCII-
cTeHunn, oxpyrnoil ckopmbi, 2 X 3 CAI, pe3Ko oTrpamineHHaH oKpywalomeil
maim manonHoil n:ene3bi. B OTACJIblibIX mecTax OT neplupepHn 011yX0J111 OTX0-
A1T umpoKne TOKII BOJIOKIIIICTOrl 6e,11,H0i1 KJIeT011HbIM14 3J1eNIeliTaMIL
BcrpetialOTCSI ynacTKI1 CTI.110111H011 rnantuni3au,HH TKa1114 C Koe-rue coxpaHHB-
111IINIIIC51 aTpoctmtmumit Hn,paNni. Cpe,flui romoreHHux nynKoB pacnonarmoTcH
-/Kene3ncrbie nepepe3aimbie B palairtnibix HanpanneHmx. CTeHKII nx
yronutenbi, COCTOSIT 113 RereHepllposaHHoil 3J1aCTIIKII, o6pa3yrouteil mHpoKne
myckTbi BoKpyr npOCBCTOB. npocneTbi npoToKos BbICT11a11bI ynnomemium snn-
Tennem. MecTam11 UpocaeTbt 11pOTOKOB BbITIOJIHeHbI pa3pacTaHHHmll Kpymibix
KneToK c nemrcToil npoTonna3mol Hepe,ami KapTimbt o6.nHTepaium npuro-
E013 py6HoHoil TICanb10 C Sumemisimil neTpluilliKau,fm.
KaK B ueHTpaabHbix, TaK H H neplukepunecKHx 'oruenax onyxonn menuty
nynKamn Bonominctoil Timm! ncTpenaioTcH B CtiyaHOM Hallartecrce anemeHrot
onyxanu, o6pa3wouitie TH>KII II rpynnbi, xapaKTepHbie unH paKa Tima Cr. So-
lidum. anemewrm onyxwm TOJIblc0 impe,zuca 5113J15110TC51 60JIee NMI MeHee
B 6o.nbunmcne >ice npengraanmot pe3Kne nanexua RereHepamm.
FIpoTon.na3ma KneToK npommaHa BaKyannin, Hupa Hall ymeHbmeHm B 06b-
eme, IIIIKHOTIP-111131, AllOy3Ho 3aKpainllamarcH remaToKcilallHom, hUlK, Ha060-
pot, yHenuneHbi, runoxpomanymbi, npHo6permoT CBeTJIbIfl BHA Kax 6b1?nycTo-
ro? Hapa c SIC11011 Kapnmoil Kapnonma. Fpamma menuLy HApom Tenom
It
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
4
F
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
162 rucToaornaEcian< 11 1111T0.11011111ECKIIE 11,131E11E1111H 13 3.7101iAilECT
KaeTKil actie3aer, K.nema npeapawaerca B 6e3swepHylo c roMoreHilofi 11.111I
panonomietaioli npoTonaa3mofi.
B rtepacpepHaecKiix tiacTsix onyxwai cpe,ailoAtioo6pa3Hoii.Kapnitibi row,-
remibix nytwou BbIikeslISHOTCS1 pb1XJ1Ori C0011,111111Te-lb11011 mann, co;tep-
wawa TOIIKOCTeIllIble cocyabi. B 0KppICHOCTI1 COCy,11,013 pacnoaaraioTcH
itialmabTpami, cocTosiwile 113 J111N4011:1,11131X 11 naaniaTittiecidix 3.1e-
MelITOB II maorouepirbtx aeliKowiToa. flOCJIeiLI11IC MONC110 11a6J11011aTb TaKi
B npocaeTax pacunipeliabtx Kanimasipon. Cpeta 1 (npocp. 51. 11. PanonopT)
((I/0TO 95, Ha6.1no,aeHHe 49). ?
4epe3 Alm mecHua zetteHHH (28 V 1948 r.) 6bT.na cHoua. npon3neileira
6HoricHH. Ha nperrapaTax 131111H0, HTO B onymanH 1113011301LIJIII cyatecTuembre
113NreireHHH, KoTopme npocp. 51. ,TI. PanonopT onncaz c.neAylouulm o6pa3om:
?Ilpn rHcTanorwiecKom Hcc.neztonalutu o6Hapy)Ketto: C0e,IIIIHIITeJlbH0-TKalffla51
OCHOBa KO)KH pe3K0 pa3pumella N 0611,116110 nipoHH3aHa mericamll 130CrIa.1111-
TeJlbH0r0 11141IJIbTpaTa c npeo6.naiicaltHem ?Jurmcpoualibix anemeHTOB. CO CTO-
polibi 3ni1TeJIiij o6HappicHeaeTcH pa3pacTaHne TH)Keti noc.nwtHero c norpy-
xcemiem 11X B r.ny6b TiCaHli 110 THny BOCI1aJIHTeJlb11131X pa3pacTaHHil. llomeamie
mecTama npinutmaroT COCOHKOBbIti (nannznomaTo3Hbill) xapa?KTep. ITauttote
111-:Twhix onyxwmx, JIVIE11111,1X 11111.30T1'1111AIIIIbINI
1 65
onyxoAeayto npupoay npot(ecca a npena pare OTCyTCT61110T. rIaTorticTo.no-
nnecKiiii m1arno3; onyxoiteacieo npotiecca He oatiapyalcetto. 57afteHtta coma-
:WI-11MA) (ripocp. PanonopT). Ho 3aTem 6b1.n0 ycTaHomeHo yxy,u,ureHne npouec-
ca 11 tiepe3 mecnu, onyxo.nb 11,e./IHKONI 6b1aa ma.neHa. B naTorricTo.norme-
CKONI npoToicane nwraem: ?Pe3euxpoualuibill ynacToK ry6bi pa3mepom
3,2 X 1 X 1 CAI. 110BepXHOCTb 6110HClip0BalIll0r0 ynacTxa 11313513BJle1la. ,11110
f13Bbl MeJ1K06yrplICTOe. Pa3Mepb1 513Bb1: 2,5 X 1.,0 CM. FIpHrliCTOJIOTHHeCKOM
B o6,nacTH fl3Bb1 o6HappKena tipembinailHo rycTaH BOCIlaJ111-
lenbliasi mulmnbTpau,HH 11oAczn3HcToro e.11051, pacno.naralomancH Ha 6o.nbulyio
my6Hily y,achnennoro ytiacTKa:..Cpeui BOCIlaJIIITeJlbH0r0 umPHobTpaTa 3aJI0-
?Nem)! o6unipHble 3bI oporouesaiow,ero H HeKpoTH31IpouaHHoro 11.11OCK0r0
31111Te.111151; tlacmtnio noacepecuotneeocn etteauro-KAerottuoti pe3op6tutu. Me-
c-ramit oTtleTallno 13b151B.11sieTcsi nonoca peatcruatumo 60C1WACHU5z aotcpyo 0pow-
6C6111t1X, HeKporuattpoaannbtx It noaaepetuttxc.n peaopthiuu 311UT6AUCZAbHblX
ya.goa. OTMetIalOTC51 Taioice aTHnHtlecKHe pa3pacTaHHH 31114Te.111151 peaKTHnno-
r.ocria.rmTeabiroro xapaKTepa c o6pa3oualt1rem ?Kemny)KnH B u,eHTpe
3aK:uottenue: atumbte OAR allaaH03a 11AOCKOKA6TOttH080 paKa OTCyTCT6y1OT B
IICCjlef1013airliONI MaTepHaae. 06patqator atutAtanue KapritHbt pe3op6tittu o6-
titupubtx aTIMUtleCKUX yaAoo opoeoaeatueeo u Heop000aeauteao 311UTCAUfl Ha
00He UHTCHCU6H000 aocnanttrevzotoao nponecca? (npocp. PanonopT).
MbI nonTopHo 113yntwur nperrapaTbi 3Toct onyxanH ii mcmem TOJIbK0 110A-
Tliep,L1,11Tb ubnuenpnue,u,einible Ha6,1n0,neHHH. Kalcou )Ke xapaicTep malcpo*a-
ca./HA-toil peaKullit B .netteHHofi onyxann 60AbH011 C.? 3,aeCb Mb! CHOBa ucTpe-
ilaemcH c maKpocParamil He KK c anemewramll conyTcTuyioutero ?Bocnami-
To:113110rd illupunbTpaTa, -He KK C meTicamu Bocria,neHHoro ?tia-
ra (3TO 06eT051TeilbCTBO camo co6of1 HmeeT mecTo), a ?KaK CO cnetittaituattpo-
aatatbtAtu Oaaoutzradittt ? KatttiepoKAacramtt (pm. 96).
FIaTorncTo.nornnecKHe Ha6mo,aeH1-!H Mbl OflOJIHHJIH elle1.111aJlbHbINI 1111T0-
.110r1ItIeCKIINI Hcc.neAoualluem ic.cleToK nepuoil, BTOpOrl II TpeTben 6HoncHH, co-
CpCAOTOIIIIB BIIIINIamie .11a cpaBHIITCJIbliOM H3y14eHuhI pa3mepos Hilep 11
ULpbi-
WCK, a Taime Ha H3ytielni11 cAuHrou B COOTHOLLIeHH11 pa3Ntepou Supa H H,Ipbuu-
Ka. B 3T11X Hcc.nuoualuisix Mb! 111.1111 no nyTH, KOTOpbICI 6bIJI Ti cuoe 'yew(
npe,a.nowell Malc-kapTH (1925-1933) 11 pHAom Apyrnx Hccoe,ouaTe.neil,
yTueplataBWIIX, rllnepTpocPHH 51,apbiunca 11 oco6eHHo Hapyweinte 0TH0ille-
111111 pa3Mepoi3 Hitpa K pa3mepam H,apbtunca,, HeagercH cneumpunecKtim np1131-ia-
NOM 3.noKa4ecTuelmbix K.neToK (Ma!-KapTH 11 Xaymeaep, 1934; Faam H A.nex-
can,aep, 1936; (1)1m.nep, 1935; A.neKcauaep 11 BHpA, 1936).
01UHalco B aliTepaType IleT e/u1HcTna no Bonpocy o HApbuincosoil rnnep-
Tpocinui, Kalc oco60m aoAtuHupytottieAt npit3HaKe 3./10KatleCTBeHHbIX KJIeTOK.
Tanice ocraeTcH He HellbINI Bonpoc 0 TOM, B KaKOrt Mepe 3TOT rip113HaK CBOci-
cmettex T0Ab1t0 KJIeTKaNIII 3.noKanectseHHbix Houoo6pa3oBaHtifl. ,E(.7151 panel-um
..3111X B011p0e0B llama coTpy,amlua E. IcHpruptHilicoua nocTarma cpaBHHTeJlb-
lIbIe rta6mo,aeH1ui Ha.L painntnimmH COCT05THII5INIII KJIeTOIC M0JI011HOPI xce.ne3b1,
trio ,ao.unto 6bulo TIO3B0J111Tb 11pOCJIC7IITb H3NICHeIlI151 51,1pbninca KjleTOK B Hop-
me, rum ninepemim )1(e.ne3bi BO upemil 6epemeHHocTH, 11, HalcoHeu, npn
pa3pacTamul 31011 we NI0.110t1H011 mceze3bi (afiseHolcaptuntoma).
Ha6.1no,ReHHH E. KlIpIllitIHIIKOBOil 1103B0J15110T c,ae.riaTb c.ne,ayloume BbI-
1. B IckeTicax paKonoii onyxanit 1-ia6.nro,aaeTc1 3HatinTeabHa5t rHnepTpo-
411151 5111,pbnaKa;
2. rHnepTpocpiin upbruma He 51B.1151eTCH cneu,HopipteCKum ?npH3Halcom
meToK TOJIbK0 palconofi onyxwm, Talc Kai< no,ao6Hbie xce.KpynHble 51,aphiu1dn
6bian o6HappKeHbi 13 M0.110t1H011 Nce.ne3e 6epemeHHoct mbium.
arclua c.nexcyeT, HTO A,nsi npaicTnnecKHx ?ue,nefl 1.111T0AllarHOCTHtleCKH 3.110-
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
OID
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
111CT0.101'11tiEC1ME II 1111T0.11011111EC1IIE 113NIE1IE11101 13 3.1101WIECT
KatiecTsemtoil onyxoan pa3mepb1 impbunica ueMoryT 6bITb itcrioabsoBairbt 1130-
.ruipoBaHHo OT apyritx ripB3BaKoB paKoBoil IIJ1eTKH.
no3Tomy NIONCHO ouzo ynepK,ztarb, trro KpuTepnii 3J101CatIeCTI3e11110CTII,
BbIABIll-lyTb111 Mak-KapT11 Hero nocae,loBaTe.mni, tie nmeeT camwtomeiontero
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110ii C. no,a, B.111311111CM unnorpnnannoro npenapaTa. Alla/1113 maTepnana Tpex noc.neasma-
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110/1,0611bIll CB11,aeTef.11bCTByeT 0 TOM, IITO YmpbuuKo-sukepHoe OTHO-?
weane noc.ne .nettemisi wimoTplinamluim npenapaTom 113Me1111.110Cb B cTopoliy,
xapaKTeptiyio X151 fiso6poKatlecTBeynibix imeToic.
I/13 npitBen,einibix cpaBlurre.ribBbix immepenuil MbI BnpaBe 3aK.11101111Tb,
B ?MINIMUM sutpa 11 51,11,pbanKa B mencax BTopoil 611onctni ,HaCT)7111I.1111 Cy111,e-
CTE3e1111bIe CII,B11111, np1ItleM c.tuniru, xapaKTepnylow,ite .fropmaaimaumo smep-
110-51ApbILLIKOBbIX cooTBOulemifi.
Bean )ice Tenepb cpaBBBTb Aamime, no.Bytielmble rip11 Rapnomerpriu Ma-
leplIaaa 3-fl 611onctur (onyxamb onepaTuBno 6buia yRa.trena) c Tem, t1TO 6bkno
yczanomeito A.nsi pa3mepoB sutpa n51,11,pbnIlKa B maTepna.ne .241 611oncini, TO
M bl ,110.11)KIlb16y,ttem npimitaTb, LITO B noc.rrexteNi czytiae 51,r_Lpo II SmpbuuKcy clioBa
IleCICOJIbK0 yBe.11111111.11I1Cb, OJII1aK0 pa3mep B,B,pbauKa .Bce )K tie ,n,ocTBraeT Tex
1)a3mepoB, xoTopHe 0110 IINIe.110 /1,0
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C1131Ir B cTopoBy Bopmaan3aulin SmepHo-HApbiwKoBbix onioulemtfl, 3aTem
tie-
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11e111111 atteptlo-stubiwKoBbix 01110111e1111f1 '13 ICJICTICaX OITyX0.11I1 ,11,0CTaT0t1H0 otie-
Buell ii AocTaTotnto xapaKTepell.
CotieTaB aTIIKaptiomeTpmecidie itaHHbIe C naTorncTo.norntlecimmil Ha6.nio-
1:CH1111M11, MONC110 C )10JINCI1bIM npal3ON1 yTBep1C,aaTb, B TKamil onyxo.rni
6oabirofi C. npou3oumn matniTeabBbie rticTozorntieclate il uswro.normecKite
113Melle1i1151.
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ritcToaornitEcutiE 11 I111T0.10111'IECKIIE 113MEI1E111151 B 3.10KAHECT
r10,11/30ASI Tenepb ItTorn nem Ha6J110)1,e1IIISIM, nicTanormecKum 11 11,11TO-
JI011111eCKIIM B onyxann ry6bi 6anbHoil C., MbI monceNt yKa3aTb Ha nan6o.nee
xapaKTepHble cnimirll. B ortyxami 60J1bH011 C., KoTopan HincaKilm Tepanewni-
necKum B03,11efiCTBII5INI, Kpome nunoTptinannoro npenapaTa, ire noAtteprazacb,
Mb!
1. 143meHeinte 11 pa3pyweinte paKOBbIX meToK.
2. Bunemut magotPara.nbnoil peaKunn 13 yttacmax, rite y3.1131 oporoue-
Bamateron1-IegoTH3HpouaHHoro n.nocKoro anitTemut nonaepraioTcn 111r1111110-
KneT0nnoil pe3op6uun.
3. Bce 31II SIBJ1e111151 npoTeKatoT Ha (1)0HC npKo ubipa?Kettuoil 130C1111.111-
TeabHoil peaKuini.
K 3TOMy c.ne,nyeT Ao6aanTb, trro cpaaHemte EJICTOK nepuoil 11 uTopoil 611-
onclut AemoncTpaTHuHo noKa3bwaeT Tamoe 113MeHellne B coaepoicanun piiGonjj-
icizeunocofi KoTopoe xapaKrepHo 0.151 ti.7e7.01( ao6poKairecreemibtx,
HaKOHen, Mb! BHLL1IM, KK anHoupemeHHO npolicxunT KapnaloeuttecKue
noKa3b1utuo11.ne Hopmaamaituto suteptio-upbtwicoubtx OTHOIllen1111 13 0Ily-
X0J111 60.71b110fi C.
B u,e.nom, Mb! ,a0J111(1-Ibl KOHCTaTlIp0BaTb B onyxon11 60.nbnoil C. onpeae.wH-
tibia K041111.11e1CC 1(lITO-OUCTOA0allgeCKIIX II3NIelle111111, o6yailoonetumni riptiNtene-
mteNt unmorplinaHHoro npenapaTa. 04,11aKo Harto cute pa 3 Hantrepluirb, turo
mallet-we onyxannoro ynacTKa 6b1.no nponne,rteno B TOT MOMeHT, Kor,na Ha-
tia.nbHbie 6.naronpu5lTHme unTanorimecime noKa3aTeJ11,1 1-IeCKOJIbK0 yxy.nulli-
J111Cb.
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nem 6bLna ubunicaHa 113 KJIHHIIKII. HecmoTpn Ha ,HaCT0111411BbIe y6enmenitn
npo,namaTb mrbeKutini, 6o.nbHa5I npepua.na 'Ix Ha /1:111TeJlbH131i1 nepno4, ge-
ment!, TIOKIIHyB ropo.n. Kora, CllyCTS1 9 women oHa BlIOBb B0313paTI1J1aCb B
KJIIIIIIIKy, TO Ha mecTe onepaunotutoro py6u,a 6131JI KoHcTaTtipouaH pannu-
undfcn peumunu onyxann.
Iloc.ne seem cKa3aHnoro nocTaTomio npocToro COTIOCTaBJIeHlin Auyx c.-ty-
traea?panee orincamfort onyxann 6onbHoct 1K.11Tenepb ripnueemtoro
onyxanit 60JIbH011 C., IlT06b1 K 3aK.T11011e111110, tITO B 060I1X c.nyna-
zx Mb! nmeem KaK 6b1 nocze,nouaTenbribie cTaxnu ertultoro npou,ecca: nepubiii
cayinail 3axuaneH HaTra.nbHoil CTa,r(1111, uTopori? B 0,4110r1 113 (5anee n03,zintx
cTaxtil.
CaeJtyloutee 3BeH0 B na6.rnaneHunx Hafi, npoueccom o6paTHoro pa3BITTIISI
paKa ry6bI no umunntem usH3oTplinaturoro lipenapaTa AaeT Ham Ha6.11one-
Hue Hu immeHertHem onyxcoll 60J!bnoro .11-uoua (Ita6.rnarteHlte 4-e), v KOTO-
poro TIJI0CKOICIeT0t1Hbril oporoBeHaioundi pa K ry6bi 6b1J1 nOJIHOCTb10 itineneit
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?Ke.nan nposepHTb nanytreHHbiti JIM TepaneuTHneciutil pe3y.nbTaT, um( pv6eu,
o6pa3oBautur1Ic51 Ha 6bunue11 3110KatleCTBeHHOCI 011yX0J111. 3Ta TKanb 6bi.na
nomteprHyTa nago6Homy Hcc.ne,noBaHuto npotp. 51. JI. PanonopTom, KoTopmfi,
B CBoem 3aminageH1311, ycTaHosHB nonHoe OTCyTCT8lIC 3.10Ka4ecTaenHbIX Kj1eTox,
Haulm B QIIHOM npenapaTe cpe,rut COMIIIIIITeJ1bH0-TKaHHOil OCII0BbI 6110nCIII)O-
BaHHOTO Kycotnta, npomaHHoil otimtpo-rncTnouriTapHumull noa3maTnnecKlImil
KJIeTKaMII, y3e.noK, itenTpanbHan tlaCTb KoToporo COCTOSI.TIa 113 oporouemoutux
tteuryeK, OKaHMJIeHHIDIX BaJIOM ICJIeTOK. (npocl) SI. 31. PanonopT).
Howie nawreAbHoro aettemin onyxanb HcLieina 11 MO)KHO 6b1j10 nepefiTH
K Ha6.1110/1e111151N1 Ha,rt AJIIITeAbHOCTb10 rtanyneHHoro TepaneaTitnecKoro 344eKTa.
B 3TOM COCT051111111 60J1bH011 ULU LteNtoHcTptipouaH KommccHt! xgyprou B
cocTaue AefiCTBIlTeJIblIbIX t1J1eIlOB AKa,lteM1111 Me.LI.HWIHCKHX HayK npot1). Ky-
nplinHoua, !wo(!). MeJIbHIIKOBa H pc= Apyriuc
HecmoTpn Ha ,nainibie ocmoTpa 6oabHoro H aprymeHTatuuo npo4). 1-litcHe-
mita, a Taime mileHrie npo(1). CunTyxima, AoKTopa 14. Ampeesa r Apyrnx ,K,1111-
111111,11CTOB, Bbnueynaaannan He coma BO3M0)KHbIM npH3HaTb, tITO
60.11b110r1 F. upaKTnnecrut 3Aopou, 6anee Toro, HeKoTopbie KOMHCC1111, H
nepuvio otlepeab .npo(1). Me.nbHHHoa, HolikpeTHo yKa3a,nn MCT, ute, no
11X minim, HmeioTon 3.noicanecTuemibte IHouoo6pa3ouamin, 'He Hc4e3Hymulle
BO apemn .netlemin W1130Tp1InaIllibIM ppenapaTom. BB11,11,y 3TIIX 06CTOnTeJIbCTB
II nO 0c06omy HacTonunno npotk. ManbintKoaa, abnnerta3ualtHan KOMECCH51 no-
cTaHounna uce nau,o3p11Te.ablible no paKy mecTa onepammo y,11aJIIITb H non-
neprHym rucTanornmecKomy aHamt3y. YKa3aHHan onepautm 6bi.na npoH311e-
.nena B npneyrcrann '1.1 no 3aAaHltsim npock. ManbturKosa. OnepaulloHiHmil
Ma-
TepHaJI 6br.r! on.nomthipoYaH H oritaH Ha Hccze,loaamie cneulla.nbnoci aaTopH-
TCTIIOR KOMITCCIIII, cocTonuweil 113 MOCKOBCKIIX 11 .rtetutHrpaAcKHx inayanoro-
aHaTOMOB. cIpituaturm 3atunotreinte 3To11 KOMHCCIIII B opHrmia.ne (KypcHa BbI-
Amen Haw!).
?npn ruCTOJIOrtinecKom Hcczedttouanint (10 XII 1948 r.) npenapaTou HH)K-
ry6bt o6HapynceHo CJIeiLymulee:
1. B 0,111TOM 113 ynacTicoa KoHcraTnpyercH Haxemie alcawroaa Hapuy co
craamotaamiem cocotwoHoro C.11051 Ha orpaniutettHom yliacTice. B 9TOM yHacTHe
oTmeHaeTcH pa36117'ne py6ti080t1 mann B. TIO,II3MITeJIHaJIbHbIX CJIORX. OTme-
maercn 0611.nbHan BocnannTeabHan mulniabTpaun Cy631111TeJIHaJII:abIX CJI0eB
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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170 nicrwionvIECKBE II 1111TOJIOTIFIECKIIE 113MP:11E1111n 11 3:10KAtIECT
cocTosnuan no npenmytuecTsy 113 KJ1eTOK zumtpott,tworo Tuna c npitmecblo NieJi-
Knx TIICT1101.111TOB 11 CH,H1111t111bIX n.na3mamtlecK11x KJ1eTOK.
B r.ny6itHe 6HoncitpoBaHnoro KycotiKa o6Hapywenbt.ny4nat nonepetmo-
no.nocaTbtx MbI11111, Taime npomtBainibtx TB)Kamil 1)y6uoB0lt TKa1111 11 pb1XJIbIM
K.rteTotangm HIlli.111C11X npu3HaKoa onyxonecoao npolfecca He
o6papymeno.
2. BO BTOpON1 113 Hcc.neitoBatrubtx yttacnott TaK)Ke o6nappKetia KapTInta
aKauTo3a it rHnepKepaToBa.
B C0e,LUIHIITeJ1b110-TKaH110r1 ocHou oTmettaeTcst pa3B1ITIle py611,0BOil TKa1111
Ha orpaHntieHHom vtiacme 11 sut.netntst AttOy3H0-xpoinitlecKoro rpanyanunott-
Horo Bocna.neHnst.
B my61tHe HcczeitoBaitHoro npenapaTa o61Iapymella TKaIlb CJ1101111011 /KC-
JIe3b1 C BOCnaJ111TCJIbliOrl taulunbTpauttert CTpON1b1.
T 'pima/cos onyxoneeozo nporiecca a 3T0M npenapare ravice He o6Hapy-
oiccwo.
3. B Hccrie.ztoBaHHba Tpex AltmcitamttecKitx ymax o6nappKetta TOJII3K0
KapritHa rnnepn.naBint He cnervapattectweo xapaicrepa.
Ilint3Hatcoa nepauttH000 unit AteracrartviecKoao onyxoneaoeo npollecca
1111 6 OaH0.111 113 UCCIlea0881{HbIX AtiAtOartittecicux Y3.406 He oGnapyoiceno..D.
3T0 BaKruotteHite curial-to Komuctrect namnoro-ailaTOMOB B cocTaBe:
npocit. J1. 111a6a,u, npo4). A. apyKoBa, npock. r.na3yHoBa, npo(1). 51. Pa-
TIOTIOpT.
Bpaa JILL tITO-J111(30 MO)KHO ,(1,06aBlITb K noc.nerutemy BalunotieHmo it Bpsut
Jill NIO)KHO tnepeoueHirrb ero 3Hatieflue. Conocramneve naTormTanorittlecKoro
BaKrtioneintn C 311111KHbI
6b1Tb H.0110JIHeI1b1 II conocrap.neHbi c Tem!!, KoTopble ornicaHbi B HepBOil gam
pa6oTbr npit Hinmernin KJIIEHHtleCKIIX HaornoneHinl, Anarn13 Beex HccnertoBa-
HHa B ue.nom 1103BconeT ycTaHOBHTb HeICOTOpbre o6utHe 3aKOHONIepHOCTI1
o6pamoro pa3Bwrirti 3J10KalleCTBeI1HbiX onyxanert no, BJ11111H11eN1 um3oTp11-
naltHoro npenapaTa. 3T11 H3MeHeH1151 oxBaTbisaloT noBe,rtemie maKpotpara.nb-
HOfi ClICTeMbl, xapaKTepHbie 113MeHeHHH C0e,a11HIITeJlb11011 TKaHII II, HTO 00060
cyutecTseHHo, 3aTparlivaloT OCHOBHbIe CBOCICTBa eamitx paKoBbrx KJIeTOK, o 'rem
CB11,/(eTeJ1bCTByIOT II3MeHeHBH IIH,T(eKCOB, pa3Mepirbie cumuli
nitep, xapaKTepnaB nepemet-ta caNtitx strybiweK 11 Hitepli0-51,apb1111KOBbIX OTHO-
memicr. Flo usenomy pstorty nputrHH rncranorntiecKnii aHa.n113 Kruantitecxoro ma-
TepHaza noxy,aa nmeeT HeCKOJIbItO cpparmetrrapHbai xapaKTep. Ho naparme.nb-
HO 311111 Ha6rno,rteHt1st1 BeJIHCb HCCJIeitOBaH1151 Ha,lt rticTonorittlecturmit, rncTo-
XIIMIttleCKHM11 1 WITOHOTIItleCKIIMI1 1,13Mellefmmu B 011011TalIBbIX H nepeBHBato-
ItEll111.1X 011YX0J151X, JlEtlE1111131X 1111130T1)1111A11111,111 IIITHAPAT011
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171
mitxcsi onyxormx HtlIBOTI1bIX. FlplItIeNI OCHOBHb1M11 061,CKTaM14 mytteHml crty-
WHIM Kapuunombt Kposninca H cnotrraHuble onyxo.nil mutual. K 113.710)KeHHIO
11ToroB Ha6mounit1l Has, atumu o6veKTamn Mb! H nepexo,uum.
HA6J110,11,EHI451 HAA onmoasimit JIABOPATOPHbIX )1(14BOTHbIX
1. al111511111e wit3oTpurralinoii Illi4leK41111 ii uth3orpimatilloro npenapaTa
siaKapaiwomy Bpayti-lbipc
Ham Ka3a.nocb, tITO aHar1!t3 pa3:11114I1b1X BonpocoH 6HoTeparuni 3.noKa4e-
CTI3e1111131X onyxorteil moweT TOJIbK0 BbutrpaTb, eC.1111 B Kpyr Haulm OnbITOB,
110MIIMO cnowraltubtx onyxourt MbIwefi, 6yaeT BormetieHa TaxaB Tpy,a110 no/1.-
,naloutastcy1 3KCIIeplIMelfTaablibINI BO3HerICTBIIHM onyxo.nb, KK KapunHoma Kpo-
;1111(0B. OCO6blii ititTepec sTa onyxo.nb inpeacTaBaBeT A.nH peweHHB BonpocoB,
CB513a1111bIX C JI,CiICTBlieN1 npOTHBOpaKOBOTO aHTH6HoTHKa KK Ha tipotiecc Atm-
cra3upocamin, TK 11 ero BJ1115111112 Ha yoice pa3eti6un1ec5t AteracTa3bt. Bayep H
LieitKep (1935) cnnTaioT, LIT() Kapunnoma Kpornixa oco6o npitro,n,Ha xemo-
TepanermttlecKitx HenbtTaintii: qT0T, KTO 113J1etHIT 3Ty 011yX0J1b, itmeeT xopo-
Hine nepcnewritabt 113.11e1111Tb oupyrne, B tlaCTHOCTII, tie.nouttecKne 131111.bI paxa?.
Apyroil awrop ,aomaK (Dornack) TK/KC yKa3b1BaeT Ha tiocinoiturenbnylo
c1'ot7Kocrb onyxoAell Bpaym-Htipc tc repaneartvieocum 803aelv1CT81111A1.
443 Bcex mHorotnic.leHilblx TpaticrutanaullogHbtx onyxanert iKIIBOTI1b1X,
no.nyttemibtx 3a ;rr)c.neotutee rtecult.neme, 6Atoce aceeo tc cnoRranHoduy iteno-
aegrecKaity pay CTOHT two:limbs' onyxo.nb 5paytt-1111pc?, nHuieT 51. Hap-
TOJIbeB (1940).
Kai( noKaBa.no noApo6Hoe Hcc.neAoBaHtte, npoBeiteHHoe B Hamel .na6opa-
Tomtit r. C. wooTpHrtaHHan 1114eKLI,1451 npoTeKaeT y KpOJIIIKOB
BO cpaBiteHitio c mbnuamtt Becbma MHTKO, BCC Kp0.1111KH BbI3H,0paBJ111BaTOT, npli-
tieNt B neptiOeputtecicoa Kpoatt o6Hapy>KHTb TpitnaHocom He yueTcB. OH11 06-
HappKimai0-rcH B Bug earn-um-lux 3K3emnaBport BO BHyrpernmx opraHax:
anmtkaTittlecKitx xce.neBax, mlloKapae, ce.neBeHKe, netieHH, notmax 11 Hauno-
ttetninKax. Tem He meHee pa3I3irrire1111130TplitnaH11011111-upeKuini npeampautaeT
BbICOK0f1 Mepe meTacTaBitpoBaHne II Bbl3b1BaeT perpeccino nepB1114110r1 ony-
=111. Hinin6wropHoe ,rteficrinte B 3TIIX sKcnepHmewrax moweT 3aBlICeTb TOJIbK0
OT cpawropoB, Bblpa6aTbwaembix uniBoTpnnaHym, HaX0H,11111,1IXCH B paBrattnibix
BnyTpetuntx opraHax. OTMeTIIM, tITO untBoTpunanym He npomiKaloT y Kpo-
Alma B onyxorteByto TKaHb 11 He BcTpetialoTcti BHyTpit ITIOKatleCTBeliHbIX K.ne-
TObliCn, jeKial K 3TO 6buto Hamn pallee onnaHo Arm capKom H Kapumom 6ertbix
m
ConocTaBoRB itaHlibte onbrros I'. C. 10mat1eBa Hau paBaHmem xporm-
tibeil Kapututombl y KOHTpOJIblibIX 11 Bapa)KeHlibtx untBoTpunaHym paKoBbtx
KporniKou, HeTpy2tHo yeTaHoBuTb c.nertyloutue Bamoible MOMeHTM: 1) 1111130Tpli-
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JISIX npoitecc ymennuemin H Ame no.nitoro iictiemoseinin 3.noKatiemenitoil
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imaKTIIBiroe, ynittiTomeT ee CHOCO6HOCTb K Ambnernnemv pa3Nlitmennio I!,
napywan meTa6arni3m, metier 3a c06011 ynce 5IIVIeH1151 Tinnumoil Aerenepa-
unn IT ymnpatinsi.
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nue nccaeoBaTestrn npitimexaeT npopacTanne neKpoTnnecKnx 3011 11 ytiacTKoB
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calnible riicTmorntiecnie, turr000rnnecnie RBJ1eHlISI moryT 6b1Tb Bbipmembi
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angel= X 350. Kapnwa allanorutinaK TOrl, tITO na6.n}ca.a.nacb y 6o.rmoro JI.
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Pitc 103. Ltaabitertunie acrelicpaTimble II3Meue-
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12: CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Pitc. 104 Boace 11031.IUH1 cTaaitsi ii3meliciiiiii KaCTOK
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Pile 107 Flonit6.nacTbt cpexi T101111 pa3pytueliiio -
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 ? CIA-RDP81-01043R00190008norn_R
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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CTBOBaTb 1111130TpIlllaHlibIM npenapaTom;
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Hym, nozytieRFINX 113 Kpoeu OICU6OTH6IX, MMKHO, npH cTporom co6.1noAeHm1
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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lie TO.IbK0 )KIM II pa3mHoN(a.ric11, 110 trro6bf on npoOp1upoaa.4 KanueparniTn-
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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06mile 13b1B0abl, Heo6xo,numo paccmoTpeTb oTAe.nblibie coral' 113 Bb1lllefia3-
LaillIbIX 011b1T013.
Album) 5651. 1'13Me1le111151 3T0f1 011yX0J111 B npouecce JletleHlig npeAcTaB-
.TisnoT irecomlfeli 11 bill IIHTepec. Pa3mep OrlyX0.1111 K HatIaJly onblra 6131.1
1,3 X 1,0 c.it. oenewlem 6bi.na npoilme,a,efra 6Honclisr, 130 Bpemn KOTO-
pofi 6bla y,na.neu KyconeK pa3mepoNia 0,4 cin, noc.ne nero ToTnac )Ke 613100
Hanaio oenenne. Ha wecTofi aC1113 pa3mepbt onyxo.rm 6buni 0,7 X 1,0 CAI,
HoCile tICTO X0.113 cTa.la N1041,SICHI-10 ymenbularbcn II Ha 26-ri fiseHb, nocne.1-
aellb 31:cnepirme11ra, npe,ncTaBanaa o6pa3oBaHne 1)a3mep01 B 0,3X0,3
TaKIIM o6pa3o1, rucTo.noriplecKomy 11 UlITOJIOTlitleCKONly aH2111113y no,nae)Ka.na'
onyxo,nb, 3Han1rTe.nbi10 ymeHbununuancn non n.ininnnem BBe,nenitH W1130Tp11-
Haffner? npenapara B A03e 130 KE 3a 26 nurbeKunii.
FurcTo.normecKan KapTiffia onyxo.nn 50 .witenttn: afaeHoKapuithoma
>Ke.ne3bi. Roue izetteftm B OrlyX0J111, HapH,ny co 3HatinTe.ribHbIM ee
m011131.11e1111CM. BD01130111.11I1 cyfuecTBennbie rucTo.nornnecKue It uuT000rime-
Chile cjniiru. OTNICTIIM npe)K)ne Bcero ymeHbuieHrre pa3mepos Haep paKOBbIX
KJIeTOIC 11 romorefnmau,fno.nx cTpyKTyp. KapTima oftero cTpoeHmi onyxoon
no.nnocTbio Hapyinefra: BluuIbI TOJIbICO OTILeJlbHbIe rpynnbi paKOBbIX KTICTOK,
1iaX04,2111,11XCSI B cTazoill AncKon.neKcaunil. Ale)KAy rpynnamn paKoBbtx KoeToK
pacno.no?KeHbl o6unipHbie nonn, 3anciafteHHbre Han romoreHHofi 6enKoB0il mac-
B xoTopoil BcTpenaloTcg OTACJIbH0 pa36pocaHHbre paKoBbie menui H OHM-
(1)0unTapirbie KaeTK11, IIJIIt 6OJIbUJIIM11 vtiacTKafu1remopparun. Ha npenapare
o6unIplIble COMTHIITeJlbH0-TICaHHble pa3pacTaHHH. He manylo nacTb
npenapaTa 3aHlimaioT 311atinTe.ablibre cKormemin d-ufm()ounTapnbix KneToK,
cpen,11 KOTOpbIX, KaK HcK.rnoneHile, BcTpenaioTcn Onle.r1bHbre paKoBbre KJIeTKII.
HaKoHeu, BCTpetialorcH 3Ha141lTe.nbHme ytracTKII onyxo.rni, rite BHilHbI T0,11bK0
113o.nupoBaymble Hapa, Haxo,nsfuulecn B pa3Jur1ibix cTa,n1Inx ,nereHepawni
pacria,na.
MbIlllb 5642. rficTo.nornnecKan IcapTHHa OrlyX0JIII 50 Aeitenusz?adeno-
Kaptiunaita. Ha ripenapaTeBitalibl o6unipHbie HOAR paKoBblx KJIeTOIC, oT,ne.neH-
Hb1e ,apyr OT Apyra TOHICHNIII COMIIIiIiTeJibH0-TKaHHIPI AM npocaonKaM11 ? Onv-
n.rincQifiinri in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Cop Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
186 IIICTOJIOTIPIECKIIE: II 1.11a0101114ECKIIE 11331E11E111131 B 3:10KAllEC1
X0J1b mien A0B0J1bH0 MHOTO KpoBenocubtx cocy,gor3 c pacumpennbrmn npo-
cueTamll. HeKoTopme cocyAbi cartepKaT cepo3no-KporminicTble Bb1110T131. Me-
cTamil Ha6maRaioTcsi ygacrial HeKpo3a H ne6o.nbume cKonaellim .nlimtpounTon.
SI,npa paKoBbix KJICTOK 3aN1CTII0 Kpyrnibix paimepoB c rnnepTpocimpoBalmbiNtli
sutpbauKamir. (Dopma sulep no.nlimopqmaH. Pa3mep mep ii mriallumerpugecKnx
eilianntax Kane6.neTcn B npute.nax or 4,5 .no 18,3. Cpexinii pa3mep BApa pa-
KOBOil ICJ1eTKII (Ha 100 K.neToK) ? 10,4. OTIYX0J1b 6bicTpo pacTy11051. 1-la 100
no.trefi 3peiniff BcTpegaeTcH 174 NIIITO3a.
I7ocne nettemen B Tetlemie 96
Aller1 011yX0Ab ymenbtuunacb 6onec tress( ii
TPU pa3a: ncxoxibili pa3mep 1,8 X 1,5 cm, KoHetnibiri ? 0,5 X 0,4 C.,11. rIICTO-
aorntlecKan 11 unTanorngecxan KapTHHa onyxann pe3Ko traiteminacb. Ha ripe-
napaTax BILE(Elbl 06unipHbre nann CIIJIbli0 It3MeneHllblx paKoBbix KACTOK, B KO-
TOpb1X 1311X1b1 51f3j1C1-11151 si,Repiroft AereHepaunn, ,nintho3a, it KapnopeKcllea.
Rap H3N1elleHHbIX ?paKoHbrx KsleTOK rycTo H romoreHHo oKpatunBaioTcsi rema-
TOKCIIJIIIHOM, flapbUUKU tie 8Uolibt.110C-Jle aegennst 1Ia6moitaeTcH pe3Noe YMellb-
weime pa3mepa naep. Pa3mep smep B n.nainimeTpligecialx exilinuax Kane6-
aercn B npe,/te.nax OT 1,9 Ao 5,6.
.1C,IC111131 10,4
OTHoweHne pa3mepoB 51,Rep onyxann: =? 2,9.
ilocae aetiemin 3,6
Ha npenapaTax orpomuble XIICTO3HbIe pacumpeirim nnoToKoB co-
CV,II,OB C CepO3H0-1(p0B5IRIICTbIM BbIllOTONI, a Tauce T10.151 HeKponitlecKoil TKaHlf.
Aleeramn BcTpegaeTcH JIHNIcpounTapilasi HtujmnbTpaunn.
B pe3KONI OLT11141111 OT onyxann 1O .netreling ee KACTKII nocze aegennn ne-
pecTasnn AeJIIITbC51: .41117'03bl Ha npenaparax netientiou onyxonti orcyrcrowor,
13 To Bpemst Kai( ?Tto aegemin Ha 100 naneil 3peHng 6buro 170 MHT03013. ,,E(a.nee
cleayer ormeTirrb nommenue autpoxiix ,npouroeK coe,aunnTe.nbitoil maim, me-
eTaNIII KopoTKIIMII ygacmamtr npofnixaloweil me)K,ny paKoBbimil KJICTKaNIII, B
()MIMIC OT c.na6o pa3Birroli C0e,RIIIIHTellbH0-TKaH11011 crpaint ao nettetni.u.
Bce cKa3aHHoe Aaer. npucTaanemle o Tex ray6oKnx 113me1-ieH1Istx, KOTOpble
11p0I130111J111 13 onyxoint B Hanom B OT,ge./IbHbIX ee memax naa BJ111511411CM
wn3oTpunaHHoro npenapaTa.
Mbitub 5648. clICTOROPIPleCKaH xapTIIHa ao netteHtut: a,geHoKapunHoma
C OTHOCIITUIbH0 60J1bW1IM K0JI114eCTBOM KPOBeHOCHbIX cocyAoB, Bb1110011eHlIbIX
'Tonto. CpeAnnil pa3mep n,rtep ? 11,2 mnaHrimerpngecKnx eximmu. ileze-
1113ff KJIeTOK He gacTbi: 1311,L1HbI TOJIbK0 eximigHbre MIITO3b1 Ha Amor? no:lieu
3peHu5r. B pe3ynorare npitAteHetats uni3orpunattHoco npenapara onyxanb 311a-
,111TeilbflO yMeHbIIIIIJIaCb (6bmo 3 X 2 Cali, CTaJ10 1,5 X 1 cm).
MinTocKorurgecKan KapTHHa nocne .4ettenta: B paKoBoil TKaHrI BUTEN
6oabwlle ygacTKI1HeKpo3a, gacTbio Bbrxaungne Ha nonepxHocrb onyxami.
RApa paKoBbix KJIeTOK 3aMeTHO ymeHburnancb: cpeaHnir pa3mep supa
5.7. B oKpy)KalotHell COUHIHITTe.T1bH0r1 TKaF111 BcTpegaeTcn mHoro KJIeTOK rit-
CTIIOUFITaPHOF0 Tuna, B inaa3me KOTOpb1X 'Horpetiaiong BK./110401111H :KenToro
uBeTa. Tana.' o6pa30Nr, B pe3yabTaTe 1LerfCTBI151 wn3oTpimannoro npenapara
npon3owao He TOJIbK0 ymeHbluenue onyxamr, HO 11 pe3Koe ymeHbluerrnd pa3-
mepoB sutep paKoBbix 'UM-1'0K; B otcpy)Kaloweri coexinuTe.nbnort mann TIORBli-
diach germ BbipaweHHasi rircTou,wrapliaB peaKuHR.
MbUllb 5025. rlaTorncTanorngecKuil RHarHo3 onyxann do neiteaux aAeHo-
Kapanuoma. Ha cpe36 131141I-Ibl MIITO3bI; ozae.nbnbre 1-10J151 pa-
KoBoil maim pamezeHbi umpoKtimir npoc.noilKamH COWIIIHIITe.11b1i0r1 TKa1111.
B pe3yobTaTe net(etam B TegeHHe 36 ;mil onyxanb yMeHbuur.nacb (6br.no
1,7 )< 1 CAI, CTaJI0 1 X 1 cut). Ha InIcTanorHgemix npenapaTax 131140-1bI OT-
iteambre, XOT5I H AOCTaT04110 .Kpyrnibre ygacTKH paKoBoil TIMM. Haparty c
13E11111.1X 011YX0:151X, :11::11E11111,1X 1111130TP1111A14111111 IIPEHAPATON1
187
1111M11 BcTpegaloTcn o6wnpnbie ygacTKII paKoBoil maim c ripH311aKam11 pa3Jing-
11011 crenelin nza3maTngecKoii 11 B,nepHoil itereHepanint. Bo.nbwasi gacrb sutep
3aKpaullmaeTcH rycTo 11 romorenHo remaToKcHaHHOM, 4aCTb sutep rep51,11a
B06a1e CH0006110CTb K THriutulomy oKpauntBaluno, a oxpanntBaeTen TOJIbK0
30311110M; Ha6.1nattaeTc1 06atee ymenbweHne 1)a3mep0B agep. B .negeHHoil ony-
X0J111 Bc-rpegaloTen o6unipuble remopparmecKne nom'. I1pOCJI0fiKH coexuni-
Teabuoil mann mecTamn rycTo np0in13aHm Kpyr.nomeroginam 111-111311JIbTpaTOM.
Ailburtb 5029. BitoncHH He 6buto. Iloc.n EtHil nut
e 38 ,eeiteut rHcranornge-
don KapTinia onyxonn: 0611.111pHbre 110J151 py6u,oBoft C0e,ELIIHIITCJIbli0r1 mann
C oT.n.eJlbHbIMII ?tiara:mil merogHoro AeTptrra; couswinTe.nbilan TKaHb 6oraTo
nuckil.nbTpupoBana JIerIK01111TaNI 11, .1111N401/11TaNII1 Ii nom16.nacTamH, cpe,/tH HO-
Topbtx BcTpegalorcn eiumugHble, Aa.neKo OTCT05111111e Apyr oT Apyra ma.neHbKne
Tpy1111b1 110,I1,03pliTeilbHbIX no pant KJ1eTOK.
Album) 5027. Bnoncno do neitexu.q: onyxatib nmeeT crpoente a.nbBeannp-
Hoil aileHoKaptunrombi manotmoil ?Ke.ne3bi ((1)010 111). B pe3y.nbTaTe
38-1tHemoro .negeHHB OT 6anbwoil onyxarm (3 X 2 CM) OCTaJICH 04eHb
ygacToK, BeCONI 13 0,0 15 .it. FitcTanorugecKan KapTilHa ocTaBlueil-
cg onyxo.n11 npeacTaBafleTcn coBepuleinio HHoil, gem Ao aegenun: Ha cpe3ax
Mb! BIIJIJIM paBiromeplibte rIOJISI, COCTOSILLUle 113 KJIeTOK mimcliottuTapHoro 11,
o6pa3om, monounapHoro 11 rHcnoturrapHoro Tnna, npoHn3a1mbie
y3KIINIII TsuKamn manazwil 4mApo6.nacTn4ecKoil TKaHII, cpean K0T0pOr1 TOJIbK0
113pCilKa n3ampoBalutble OT,ReJlbHbIe KJIeTK11, 110,a03p1ITCJIblibIe 110 paKo-
Boil npnpang; 3111 KJIeTKH BcTpegaloTcH eal1}1114H0 Ha o6umpHbix 110J151X cpe3a
11 0/111 KaK 6b1 TOHyT B NIacce THCTII0TeHHbIX 3.TIVICHTOB. BC5I K.neTotman Nracca
onyxo.nu, Kpome KJ1eTOK 016po6.nacm4ecKoro Tuna, 'vier MHOT0411CJIOHHble
npir311aKI1 iterellepaultH it ymnpainin. MHorne maKpo(Imrll cattep)KaT x(e.nTbie
pallyabi (pm. 112, 113).
Mbuub 5028. 011yX0.11b B Haga.ne aegelnin nme.na ? no cpaBHemno c Apy-
ritmit ? B3HTbIN1 II B .91X1TeplIMCIIT, Ile60513111110 -pa3mepu (0,5X0,5 cm). 1-1e-
pe3 36 Audi zeneinin onyxanb cTa6n.n113npoBa.nacb 11 ,Lta)Ke HecKanbKo ymeHb-
unuracb. rncT000rngecKnii aHa.1113 ma.neHbKoro KycogKa 3T0'! onyxanii, 13351-
Toro 130 Bpemn 6noncial nepeA Haitanom nettetam, ,aaeT THringilyto KapTinly
aaeHoKapunnombi mo.notinoil )Ke.ne3bi. Bo.nee AteHee Kpynnbie ruing He-
Kpo3a B 011yX0.411 OTCyTCTBy10T; OTHOCHTUIbH0 tlacro BcTpegaionn He6arnaune
remopparlitleciale ygacTial. B pe3y.lbrare _wile/um npoit3oulan xapaK-repHbie
113MCHC1-111 51 cTpyKTypbr oKpauninemocm 60J1b111a51 gacTb gaep oKpa-
11u3:0u1r
1Blli
acn0
eTcn 6anee rycTo romoreinto remaToKcnanHom. OAHoBpemernio npo-
1 (11;leic37xexc\HII}Kenl Hilie mwromgecKoro ItHAeKca. KapnomeTpllgecKHe
p
110Ka3b1BalOT mmeneHHe pa3mepo13 nAep paKoBbix
KaeToK: noc.ne .negeHun napa 3ameno ymeHbumancb. XoTn Bce 9TH H3MeHeil1151
cnowramioil onyxann OTHOCHTeJ1bH0 He B TOM cmbieze, 4T0 paKoBan
TKaHb eme npircvTcTByeT, 110 Bce 9TH 113NlefleHII51 oco6o turrepecHbi Tem, 4TO
pncyloT nepe,n, Hamm Ty tka3y'Aet1cTBI1g t11!3oTplinaHHoroonperrapaTa, Kora
TOJIbK0 HaMeTlIJIIICb AereHepammbre 113meHern1n B paKoBon Tical-114, 1-10 pa3py-
weHne.ee eme He Haga.nocb 11, r.naBHoe, He ,BcTynna B AerICTBHe maKpotPara.nb-
nbrii annapaT c COrlyTCTBy10111,IIN11-1 51B.TleHIISIN111 xarntepomacmgecKoil
11
KaHuepanwrngecKoil peaKuHH.
NIGUUb 5026. FlleTanorHttecKaB KapTHHa xycotma onyxatm, B3 51TOTO npli
6HoncHn: remopparnecKan narnwianpHan a,rteHoKapunHoma. B pe3ynbrare
./letteHUA onyxanb ymeHbuni.nacb H ee rucTo.nortmecKoe crpoeHHe II3Me1111./10Cb.
B114,11bI 0611111p/Ibie 110J151 paKoBbix KJIeTOK, Koropme 6e3 ripexurell TIpa1311.11b-
110CTII o6pa3yloT 6anmune n maabie Ky4eo6pa3Hbre cxon,nemr, npoHH3aHHbie
K.nemamit AnmcpouirrapHoro 11 rHcmoturrapHoro xapaKrepa. B csoeH Macce
paKoBbre 1CJiTKJ1 AaloT KapTIIHIDI ,RereHepaTimbix CABHTOB: Ha6martaeTcn 6o-
-nee TemHoe 3aKpaunt3aHHe smep remaToKcihnnHom H romoreHH3auit51 B,BepHbrx
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
Declassified in Part - Sanitized Copy Ap roved for Release 2013/04/12 CIA-RDP81-01043R001900080003-6
rucToaorimcKHE 11411HTonorimEcKHK 113MEHEHH51 B 3301iAgECT
c-rpyKTyp. KapHomerpmemie 113mepellim Haep onyxarnt ,ito JICLICI11151 11 noc.ne
Jletle111151 110KB3b1BaIOT ?Hem, 60J1b.WHe cABHril B pa3mepax step: noc.ne Jietie-
111151upa pemo ymeHbumnicb.
Album) 5024. ?ao :zetteutts onyxarib IIMCCT c-rpoemie reMoppariftiecKofi
LtHc?ro-aaeHoKapunHombi, pa3mep 0,5 X 0,4 au.
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a 143 maccbt OTACJIblIbIX AncKonaeKcirponalmbix KACTOK wurre.rwoHaHoro 11411
Kpyrriome-rotnioro Tuna c Hapamil, OTJ1111111b1M11 TIO cBoefi upywrype 11 oKpacKe
or 5utepr.pa11ee Ha6./HoltaBu1l1xcH 11 paKoBoil TKamr. 3-roT cBoeo6pa3HbIrt icon-
momepaT meTom, 3ainimalownil o6wilpHble norm Ha ripenapaTax, cocrouT
Cpannenne pa3mepon flaCp B samax
nocne OC,WHIM wmaorminsiishim npenapaTom; BHAHO 311WIWITAbH0e
INWHIAHOUlle pa3mcpon suep nocoe JIC 'Jell Jill
B pe3y4bTaTe Aettentur B TeHelme 38 ,Rilefi Ha 11IecTe Orly:Walt o6pa3oBa.:1-
CSI 6eccpopmeHHbni oc?ra-roK fitc?roaorimecKHe ImmeHeHHH, uponcweitunie
onyxwm, Becbma 311aLIIITejlbtlb1: Ha cpe3e B1Fia romoreH113HpoBaHna51 6e.1-
KoBaH 6ecci?pyKTypHan macca c ytiaorKamu MCJIKAX 06JIONIKOB Hap,
Koropou .BcTpetialoTcH e.L1141111(1Hb1C Harm Jereimpilpylowilx Kpyrrromeromibix
CICOTIJIeH1111, lf, HaKOHeLL, OTHOCHTCJIbH0 oHeHb He3HatiuTezbubie yHacmH zere-
IlepllpylOWHX IcleTOK, KoTopbreJ111Wb ozaaaelino HanomilHalur 0 6bI13We1l 3,1ecb
pallee paxoBoli -mann.
Alotum 5020. rHc?ranornHecKan KapTHHa Kycomca, 13351T010 npn 6HoncHn
Oo netteattg: aiiefloKapulimoma moacmoil :Keze3b1. Hoc.7e 27 aNea netiom.(1
3ra orpomaaH onyxcob (nparrnHecKH MbIWb 6bula B35fra Ha zetieHne npe)-
GOOKailbtiOAt neptioae) 3Ha1IIITeJlbH0 ymeHbinu.nacb (6bum 3,2 X 2,2 cAt, c?ra.no
2 X 1,5 cAt). B ee rHoro,nonmecKom ci?poeHHH nponow.rul cze.aylouve H3me-
HeHlI51: 1) tlacm onyxann noltBepraacb pacrizaBzerano: Ha muKpocKonntle-
cijix cpe3ax BriijHbl o6wHpubre romoreHn31lpoBamible maccbi onyxarieBoil TKa.:
11H, .ne>mauwe Hapsmy c He meHee oaunpHbrmH T10.151A111 THIII11111011 paKOBOII
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l30Mb1 5028 ;to ii nocae action's uni3oTpiin3ninot npenaparom. 'kilo 6bmo 6b1 eute npoaamiarrb HirumeHile rucTonorntiecmix Ii 11.1110-
..torimecicitx lia6.moaeHnii HtLIL aeficTauem 11ni30Tpunalmor0 upenapaTa Ha .11p3'-
rue cnoHTaimbie onyxo.m, Hanpumep, 13, 7718, 6085, 5447, 5647 H 2986
(pm. XXVII, XXVIII, 123, 124, 125-127). Ho 11 cermac B A0CTaT01111011 Mepe
tieTko Bb1p11C0BbIBaIOTC5I onpeLe.neHuble aakoHomepHom, 1103B0J1511011.1,11e, XOT5I
H B 06u.utx gepTax, npeAcTauirrb ce6e Te ppoueccbr, myropme ripoTexamT B
cnoliTallubix onyxwmx 110A B.711151H11eN1 6uoTepaneamtlecxoro B03,/leriCTBHH. 06-
o6m,emie BTIIX npoueccou, no cyluecTay, 13B0XIT Hac B paccmoneHue npo6.ne-
Mb1 MexaHhi3Ma J1sefiCTB1151 npoTllsopakoaoro airrn6noTim Ha mokallecTaemible
mum', trro HB.112eTC1 coaelmaHlrem c1e.yI01LLeii Liam Hauler? Tpyita.
13
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
(7
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Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
196
31EXA11113N1 .11EfIC:T111151 .111T1111:1ACTON1110f0
VI 'inn
MEXAHH3M AEFICTBH54 AHTHETIACTOMHOTO IIPETIAPATA
143 111H3OTPHIIAHYM HA PAK
11,14Tan011411ECKHPI. 14 rncTanorntiEcKiin AHAJ1143
MEXAHH3MA )I,EFICTB14S1 11.11430TP14I1AHHOr0 FIPEIMPATA
BO3HIIKa1011IIIfi TIOA 113.111151H11eNI uth3orp11nadHoro nponapaTa B 3noKane-
CTBeH11131X onyxoanx npou,ecc czaraercn 113 t(e.loao pnaa NIONICHTOB, KoTopme
B CBOefi COBOKyTIHOCTI1 1103B0.715110T He Talmo cra6nan3HponaTb Hon 311ann-
Teablio yNleHb11111Tb, HO B pue carmen 110.11110CTbIO 113.1et1lITb Amex? 3awea-
wile B caoem pa3BIIT11II cnonTanbte onyxo.111. Hart6ozee xapaKTepitbie HI3J1e-
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una.nbHbix Hccaeuosamifi. Kw< 6buto ycTaHomeHo pa6oTamn Enawnata
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Declassified in Part- Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
198 -
Declassified in Part - Sanitized Copy Approved for Release 2013/04/12 : CIA-RDP81-01043R001900080003-6
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-301I ueuTtoi1f9u11 davent'-uadoM oiddx 11 uarnidiy xlsrox.cuo X1c1HHEIHOU3 g
?KC BbI3BaTb H nocaeAroutlie cTaxiii 113-
meHernisi onyxonii BI1.110Tb ope3Ko Bbrpa)Keirrioil ?KanueparumitiecKon peak-
111111.
5. Cpe,zur liair6o.nee KapaKTepribix SIM/IC.1111u npouecca o6paTiioro pamiTlin
3J10KatIeCTBeHHbIX KJIeTOK no Baioninem uni3oTplinaulloro npenapaTa na:to
OTMeTriTb CJle,rtyloutee:
a) 3w:weal:ewe ymenbutenue saepnbtx paastepoe, c necataten-
HOCM10 cetiaeredibcreytotwe o6 tiamenenutt ypoenli, a Atoolcer 6bab U xapaK-
repa o6ditetta eeuiecre KAMM onyxam.
6) 3a/cotta1tepnoe menbutetwe paesuepoe napbutual, TO ecTb TIpOlICX0:111T
nopmaarmau,nsi imepito-upbunKoBoro oTtioweniiri?pe3y./IbTaT my60Kiix, NI0i)-
(1)4113110J10111HeCKIIX c.ErBiirOB B momattecTBeitiroil x.rieTKe.
B) policxozi IT iptenburenue pu6onyK./eunoeoa KUC4077,1 B paKOBbIX KOCT-
Kax JIeICHHhIX 011VX0JlerI, C 60./113111011 nararmilocTbio AoKa3bniaiouree, tiTO lia-
pyumeTcri ,IIHTCHCIIBHbIfi CIIHTe3 6e.111(0B, neo6xo1Uimbix )1J111 pocTa 11 pa31no-
weliiin KJ1eTOK. TakttAt o6paealt, 8b1K.VOtlaCTC51 eaatcnbta (Paicrop 6bicrpoeo po-
en/ ii pa3svno.91centoi 3./oicattecreennba KACTOK.
r) HapHay c n3menennem pa3mepa ruep npoircxoanT ymenbutenue nue-
ALUT0308 8 onyxofieebtx KileTKCIX. DTO noKa3biriaeT, tyro MelIFICTCH HC TO.ab?
KO ?alien eettiecre KileTOK, HO OHU Tep.SUOT Cl1OCOGHOCTb K 6atcrpaity pad-
.11140.7/CeM110.
6. Tarthe UAW-10 113NleHIIBWIleCH no,a 13.111451111ieM ani3oTpFinannoro nue-
napaTa 3d10KatIeCTBeFIFIbIe KJ1eTKII, C yNIefIb111111311111MIICSI aupamii
rpaTuBwile p116orrymennoBylo KHC.110Ty, necnoco6ribie 1111 K IIHTelICHB14.0-
My 6e.TrKoBomy currre3y, 1111 K 6bicTpomy JeJleHrno, C 113MeHlIBWIINICH
A1eTa6oa1I31om, BcTynaioT B HOBbIe OTHOILIeH1151 C 3B W11THb1M 11 CM/la-
:NHL opranimma H 113 KJICTOK arpecciumbix, cri0c06ribrx 6brcTpo pacTri 11 paamiro-
)KaTbCff, BHUIpHTbCH B oKpy>Kalow,yio tropma.abityro TKalIb 11 pa3pyinaTb ee,
MAUI CraHO8JITC51 06beKTall aaPeCCUU CO croponbt 30NUTHbIX KileTOK U eystro-
paamblx Oalcropos opeatuteAta.
7. aroT MOMeHT CBH3a11 C fran6arree tieTiuim 11pO5IBACHI1eM BTopoil CTa-
J11111. CyllieCTBeH110 OTMeTIITb, HTO nepBbie ,RBe cTaLorn moryT ripoTexam eine
00 120518-11eHUII Knuntotec/cu yilurbteaaitotx tail/et/enact
8. BTopan cTamirr ne3amembim11 nepexoiraMH cBmarta c nacTymennem
rpeTbefi
nORBJIeHlle B onyxwieBoil TKa1-111 311a1111TeJ1bH0t0 inicara N1OHOLUITOB, rii
CTHOLUITOB, maKporfiaroB connairaeT c frapacTamem KanuepommitrecKoil pe-
anum. no mepe pacTBopeinin If yl-IIIIITO)KCH1151 3.moKatrecTBeirilbrx ICReTOK 111
IIX MecTo npounKaioT clitt5po6aacTritrecKne KJIeTKIT, iiaxQurruulecn B COCT051111111
110Bb1WeHHOrI aKTHBHOCT11, oprarin3yiourne Ira mecTe ITOTH61.1111X KJ1eTO1( coeirlf-
HFITe./Ibliy10 TKaHb. Tai, n covert-must aegcTettn U1130TpUIUMHOCO npenapara
tt ecrecreennbtx 3aU4UTHbIX CUA opeaattaita nponcxoiinT ocnoBiroil ripouecc
Bb13,a0p0B.11eH1151 tre.noBeKa HA 11 1101L017bIT1113IX )101BOT1113IX, nopanceirubrx 3J10Ka-
lIeurBefmai onyx6.71b10.
9. 13 OCHOBe BO3HIIK110BeHH5TTaKoro npouecca Amur ne,uentre B opranii3m
'60J1bHOTO OaKT0p08., KoTopue CII0C06HbI BJ11151Tb Ira ?KH3fleHI10 Bi5K1ib1e
Turn paKoBon KJ1eTKI1 H Te.m H3MeFISITb yCJI0B1111 ee ipa3Bwriani, npirtrem
HX nanpasitenno TaKHM o6pa3om, trro 3T11 113MeFICH1451 11p11130/111T lureTKy
iC rorepe 3.401ca11eCT8eHHOCTU, 11TO B.rreireT nacTynaeinie KarruepwrirriprecKoii
1111:11APATA II.! 11.11130TP1111AllYM 11A !'AK
227
peaKuilir B oprainume, B KoTopoil npitniimaeT yitacnie pria cliaKTopoB, 01111-
CalllIbIX Ham
AllT116./HCION1/11)1C 111aKTOpb1 HAICIOTCH B pflAC BILROB MIIKpoSItbIx KJICTOli
ItJlIt npoiryKTax IIX. 11{11311e,ReSITeJ1b110CTII. MOJKII0 AymaTb, trro MeXaH113M
pa3pyruitTenblioro AelICTB1151 pa3airgen, B 3aBHCHMOCTII OT HX npripubi.
kapTinia 113meneinisi onyxo.rui nojr, 13:11011111eM 3111X rliawropoB mwKeT 6bm:
CIO:lb iKC 1 a3lioo6pa3i1orr, CKOJIb M03atitilla crpywrypa mriKpo6iibix
3T1IX (PaKTopoB. Boripoc 3alynotiancri B TOM, KaKasi 113
paKonoil KJIeTK11 IIC yeToilturaa K AericTByloulemy cliawropy.
10. DTOT cao:Kubill ripou,ecc, Bbl3blIlayMb111 111113011)1111aHHbIM ripenapaTom,
nmeeT CB011 IICTKO BbIpa)KeIllIble cnetauPuttecKue 0c06en1-t0cru, OTAIPIHbIe OT
111,13b113aeN1bIX iieKoTopbrmii apyrnmii BellIeCTBaN111, npiimennembimii npir 3Kcne-
plimeirraxbuo1l Tepaniiir onyxozeil, nanpiimep, a.m.rionaom Koaxnunirom,
ropmoirom ClIfIeCTpOJICN1, capKominuniom H, naKorieu, 6aKTeptimbribbi no.ri;
caxapimom 113 B. prodigiosuin.
11. Muorutinc.netnibie itaSjuoji.eitnsi ria,1 AeficTrinem npoTuBopaKoBoro
ai-
TII6IIOTIIKB 113 1111130Tp11111111yNI, a TaKHte pn,a ,apyriix airrn6,riacT0NitiblX
timicropoB aoKa3binaioT, LITO paKOBbIC K.71eTKII Hapsuty CO CBOHNI OCHOBIlbINI
Cl3aCTBONI?azpecc118ttocrbio?o6.naz,a1OT 11361ipareAbiroil Jia6nobriocTbro,
paHUMOCTb10. 51B.71e1I1151, B031111Ka1011111C 110,3, 1141111H11eN1 uni3oTpiniantioro npe-
ii
a pa Ta SI13.15110TCH j111111b flaCTHblAl alyttaeAt 11P0IUMCHU5I emit tie6uparatbH01.1
paHU.VOCTU 3.10KalleCT6CHHblX K.leTOK.
12. Ilojryqeiin bie unTariorittiecKne, rircTarrorittiecKne, 3Kcneplimerrra.nblib1'
ii KJHhI1II'leCKlie 1ia6moiteini1 HMIOT iiaettie;1:1 o6ureil Teopint paxa:
a) 01111 CBIL/LeTe.71bCTBylOT 11p0T118 pactuttpare.ibfi020 TailK08i2HU5I iltleHUR
(6 aeronaut/a paK08blX onyxoneti UpaKoebtx ti.lerolc;
6) 01111 CB11,11eTC.11bCTBY10T nporue rilnoTe3bi, LITO pakoscat tmerica 518.11lleT-
C51 peeyAbrarau otyraatut.
11MKTIA BooppKaioT TeparieBTa-oliKariora, TK KK 01111
noKa3braaloT, trro, licno.ab3yn rliawropbi NIIIKp0611010 IlpOlICX01K1LCH1151, MO)K110
nanpaenenHo 11.3.41ellArb paKocibte KACTKU, unman 11X OCH01311131e XapaKTepHbIe
CBOrICTBa.
flIsifid in P rt Sanitized Copy Approved for Release 2013/04/12 CIA-RDP81-01043R001900080003-6
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