TICK ENCEPHALITIS IN MOLOTOV OBLAST IN 1948
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Collection:
Document Number (FOIA) /ESDN (CREST):
CIA-RDP80-00809A000700040541-5
Release Decision:
RIPPUB
Original Classification:
R
Document Page Count:
4
Document Creation Date:
December 22, 2016
Document Release Date:
October 27, 2011
Sequence Number:
541
Case Number:
Publication Date:
February 25, 1952
Content Type:
REPORT
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CIA-RDP80-00809A000700040541-5.pdf | 241.59 KB |
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CENTRAL INTECIGENCE'AGENCY v REPORT
CLASSIFICATI R
Scient.lfic - Mfedicino, tick encephalitic
1:50
'tussinn
DATE OF
INFORMATION 1950
STAT
DATE DIST. ol.5' Feb 1952
NO. OF PAGES b
SUPPLEMENT TO
REPORT NO.
THIS IS UNEVALUATED INFORMATION
n11 TOCY,T,f TY m..
O, T? ?IT? IUUT rn811 uno~ UUNT, n lO,? O,I,11?
TI 11w1N 0/ ffO,q, ACT ul
1. e. C., a, lull U. U A1nn1? m TYul1UYOa OS T? ff,YTg1
OF rtT Cnin?, 1, YT win TO Y SUIThOMU, null, tl PRO?
1101? ,T U,. UTTONOrM1 U T,l$ n,1 I/ nO,1MTn.
i.evropatclogiya i ?sil:htLtri_;;, 'i,l YIX, 'fo 2, 1950, pp 19-21.
TIC{ rKETIl/II.IriIS I`I N(Lk-froV OIcIJ.ST I. 1948
N. V. Samovich
:submitted 19 Aug 1919
CJh Icsl. ;itu:y cf t c. -ce dti;?.: in o1 7?:;v `0 OSt Ins said,
uui,Iue and cleorl, Jefira.c; ,i'alit ,r?- lished a
J ' poison with the cliaicol picture of
""cefh:aitia es dencri} 'd It, the :-- ast (SCr.:i', Shapoval, Fanov, and
th, ulna Kazakhstan .; t?'=1uv ;-r': ':andryko).
niuti cc ciiairr:i nFerript!;,:, of cues rf. ?;;riouo seasons of the year
ar? .:I:.;:r: the prrsance Of n:,r,)on,,'7 'part fro:, loc
1 peculiarities. In T','/,
: n'. o\' ch's "IR:e State of the Spi-~a1 _'luid in S,rr n;-.iuWn=r EncepL.ilitis," in
the u:.rk Gtate of the ;.plan, laid in Tic: Encephalitis, n,blished in Trudy
)blotu? s , o atonetolovirhesYo o S:stitute, Yol T, 1^143, Which was based on
, aterial hoe the yearn 193r' to 19.1, we 'ere a? le to ricte the presence of
.local mud seasonal differences In changes in the fluid, with a repetition of
thr, }:uric type cha:?acteristics.
"-'h^ p;c,'liarities of tic:- encephalitis it, i.olotov 0hlnst are clearly
revealed by observations as to the course of tick encephslitis in 1548 In the
data of the nerve diseases clinic of the Xolotov ::edicel. Institute. Suring the
summer :..o:,ths, 4'( patients .rith acute forms of tlcl. encephalitis were admitted
to the clinic from various rayons of the oblast. All patients had, before
developine. the disease, been in the woods, but only 42 percent had picked ticks
from theaselves. The first case of the disease dated from 13 Jay and the last
from 1 August. In slay, nine persons becore ill; in June, 25; in July, 12; and
in August, one.
STATE NAVY
ARMY AIR
40
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STAT
p3?;m.r:aeon , .rcerirgeal forms predominated, without pronounced focal
sympi.ms. ^.he rePhalitic form was
myel:itic in , the not+_n.~;~rcpha'.o myelitis in bested in 24 persons, the polin-
4, er,d th'- =ncephalit.- Jr, one. , the plrne in
detected in four Forms xhich were not c cleaearly lyd defiefined were xere
poraars.
A -?peon;. Croup wee forri by seven patients with tree presence of s
thal,-ia an reurovascutar dernai reactions which had not been described earlier
th
in e works of local r,europathologists. It was possible to detect forms which
were not clearly definer] ir. only the Mulyansk center, where all cases
nese were submitted to scrutiny.
of
ii_-
ithou', touchirr- on t.a:_ ch'3-acteristics of sufficiently well-known type
manifeseRf the of tic': e::cecir,lit
aspe-te of the case is, It is still necessary that individual
ur a;n,?as occurring Burin
shool7 C the season under consideration
r.. -,. ?i she cases, a
hr ,_1 course of the high-temperature pod '?''L c"y 'in:r ti temperature, the temperatureefell to6
nee.7 :':,:? 7.2 dty;, ?_?i`,lc
again. ;;cd~.r?,,;.:_ .tr. J el. i;. ,. ^:aerc in the patient's condit
and
risr., i_ scc: cases, the neurological symptom's hadn
air 'y r?:[:ctv'. -,Ile Whose wh?,n r;...
airy. ,.y ,1 n, ;?,T .;J. f,. i,.,; patient was placed under the observa_
ti r,.,amre;(' , Chile the primary period was revealed on the basis
:rr2tic^ a::d Was c;LL)rc
influen;:c, inC of i.,;.,1, .? ofoten than not diagnosed of typical as
infln. r t ;, i E reveal the presence of typical
to of c su y 1.: "3imary period. It had also been
as i ..r.r
h,,r possibl t t. tr(.nd in earlier seasons 1939, it
one f :11; - ., ... , in 1J39, it
-_ i:)~ ? Yu,tt:,rn is r ,,,
er-t ?,.:,= :. re b
i :.:;i ;!1e e.m o^ rrr.:,our.~ed atrophic paresis of
upper
in cn:j; rt ,-r+h "`~ht p+'-?sona (17%), two of they. exhibiting ethe
'e
n c re",
occu '
11'c ' er cnusclen. In six patients
parFS,rr oC ? . - E ;?accles of , there
Uc? the humeral belt. Atrophic
noteed i- 1,0
? ;tr`;,1 -; , y1c - sct In. Cerebral hemiparesis was
1. l,ar::a
Bit ,-.; Cal inrervation was exhibited by
+
c?' ? " P ' ,' hile I 1C was able
during :) U? .1;: chr, t nB the acute period, the
banc.2 0? i..- craria: :)i patient, the f"'Ictlnral distur-
the
ivnd,;r ha eeco:?.: ? ,?r i:< ir:r. of Paresthesia (the ,:l? ,r edge of
the difior1cr: i s?r roc! of the neck, oral cthers) end
The ]at
t.?, ,ri cc, i VJ ;icy;" her'L t pep' . aia) of the
i
.eental type.
lower neck, no 1__. i,? t),, "?,,?--_izr_tion in the segments of the
et the rotor c;isturbance6 which hen'
cr i of ti. 're female patient, who uc:derwent
to ho:.; f~:cc tlona, Upon dischar'c 6
't a "el`t
.. Lire fir
from
of sec ,'t,rt:; with a unique
Fol.lo?,ring a 4- to 7F,-, ?- +. , _...._
hyt-- ,r3 thr.
n e. The
,.;;, ---- ..- _ ::r L: unit or
th _ r,,-cn y , the annular hy;?err , t i c peri-
of inv .; ie7. - 8, 't a distance of 20-,,, , -- ._*
,y, . ronlia of the skin th?:rc , -,r, :V,
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general malaise, high temperature, headache (sometimes with naus
ingeel symptoms and sharp pains of ea), mild men_
, a burning,u npleasant nature, situated en
the ortremity nearest the Bite of the bite.
band of this extremity were painful to the touch.
The muscles and the neurovascular
In one female patient, who had not been receiving serum treatment, there
appeared, as the local dermal reaction subsided, individual +
elements over the entire b
of neuroinfection (genera' -Y. In the cases cited above the gen annular-rash
ROE ~eecti of e malaise, headache, ,accel ratio of
rythrocyte sedimentationhigh temperature, comleaedP
symptoms indicating that the regional a ' etic elelemesen)nts were affected oy
of pain neurovassyndromecular of sympathalgic character, change elements ( (local
skin reactions), g in sensitivity, and disturbance
Recognizing the great importance
phalitis, we sought to do of spinal-fluid diagnosis of tick ence-
everything in our
Power Measurement of the pressure of the spinal fluid b to study the spinal fluid.
nostic lumbar tape revealed i nteresting data, The taps were opt mediedlwithgthe
patient placed in a reclining position. An initial pressure of the water col-
umn of from 40 to 50 mm was established ten times; from 50 to 100 mm
from 100 to 150 mm, 13 times; and higher than 150 mm 180 34 times;
pressure of the fluid was repeatedly observed in ( in the enpe. A reduced
clearly pronounced meningeal s Patients in t
period
cases, simultaneously with ameliorationmofethe patientpsa condition, a noru of
zation of the pressure of the fluid was noted. tappings in such
Ali_
-
In investigating the fluid, lymphocytaI pleocytosis was established in the
majorit of cases, ranging from tens to the first few hundreds of formed ele-
ments /loud corpuscles? in one cubic millimeter.
The amount of protein od
not exceed 0.h5P in positive protein reactions. In inve the
leucocytosis ranging frnm 9,000 to 12,000 was encounteredtina2 % o of those
blood,
examined. ROE, as a rule, was accelerated and was normal only in t ie
cases. In the second month of sickness, a moderate eosino d
quently
quently noted. Phih ia was s not not
nfre-
infre-
The carbohydrate-salt metabolism was investigated in 45 cases and the
Potassium-calcium metabolism in 12.
Carbohydrate Metabolism
A normal amount of super in the blood was observed in 79% of thous
examined. In 11.7% of those examined, the absolute sugar content of the blood
was reduced 52 to 79 mg %.
The coefficient of nnnetret-r e
examined. A pronounced "" sugar was increased in 62. Sp
increase in bWPerglycorrachia vas noted in 35% of cases. those
penetration of the hematoencephalic barrier for sugar was unevmy
pronounced at various stages of sickness: in the first 2 weeks, in three
fourths of those examined; in the third and fourth weeks, in one half; and more
than one month after the beginning of sicknes,, in only one third.
"Salt f oflam
The absolute sodium-chloride content of the blood increased in 30.3% of
the patients. The coefficient of penetration of the hematoencephalic barrier
for sodium chloride was reduced in 65% of the cases, due mainly } .. )rrachia (85.' ), The coefficient of penetration of sodium chloride in
_rst 2 weeks of sickness was reduced in more than three fourth of thosed
examined; in the third week, in one half; and after more than a month, in one
third.
-3-
ftm*WMNW
nwAaapapm.
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STAT
Comparien of the carbohydrate and salt metabolisms for tb, period of
sickness
agreatestn them.
In the early phases of
coefficient of sugar
penetration was observed, the penetration of sodium chloride proved to be low-
ered in the same proportion. The inverse relationship between them remained
also in later phases.
Potassium-Calcium Metabolism
The coefficient of penetration of the hematoencephalic carrier was within
normal limits in 6o,>; of the cases.
Tn 40 cases, the Lange reaction with colloidal gold was performed, with a
normal type of curve being obtained in 21 cases and a change in color toward
violet being observed in 19 cases in the third, fourth, and fifth test tubes.
Of them. these changes set in eight times with meningeal. forms in the second
week of sickness ar.d 11 times with forms exhibiting local symptoms at various
stages of sickness. The type of curve obtained shows coincidence with the
syphi;itic bend in the correspording curve and with the curve for polio,nyeli-
tie. A men!nEit!c curve was not obse: ed. The data obtained in performing the
Lange rea^t.io- agree with the fluid --pressure indications, i.e., with the
absence of a n>-n1.,.6itlc curve and of increased pressure.
Completely differc,,t data were obtained by A. B. Nandel'boym In investi-
getir.g the spinal fluid and blorsf o^ patients sick with tick encephalitis in
aze.khsian. These data are fundamentally different from ours in the following
respect.: prelominsr.ce of high fluid-pressure values, different morphological
composition (,.f the cellular elements, presence of a usually meningitic curve in
the .onge reacti?cc:, absence of changes in the salt metabolism, and lowering of
the cce_fficier of' penetration for sugar. The data cited clearly indicate
dezided differences In the laboratory characteristics of tick encephalitis in
Molotov Oblast and Kazakhstan.
J n' -a*~:at^r data differ In smaller degree, and in individual instances
appr,;;:ars;e the investigations by V. V. Kartasheva of patients in the subacute
stage cf tha --stern variant of tic): encephalitis. The author notes the pres-
ence, in the / final' fluid and in the blood, of pathological s hli'ts in the
biociem-cal equilibrium of both the carbohydrate and salt metabolism (In the
majority of )8t.terlts, therF was an increase in the coefficient of penetration
for sugar a.;d pronounced hYp'--'1-?rrnchia)
.-,._ .
Pasically, to the treatmer.? ,f our patients, together with supplementary
met thods, he antiencephalias serum of hyperimmune goats was used. The serum
prepared by the Molotov 7irusulogical laboratory on the basis of crOf
Pshenichnov's mot od. p?,r_i_..: .. _
firmed the diagnosis, the patients-were! diagnostic lumbar tapping, which con-
redko, with 30 cc of serum which had been slightly heated. with,thetordinary
method of injE,ting the serum, an unusually high percentage (up to 58) of uerum
sickness was observed in 1918 in the form of skin eruptions of the urticaria
type, with painful skin itching and sometimes with edema of the eyelids, gums,
and ever, of the larynx. The pretence of aphonia, together with edema of the
larynx, could simulate the appearance of bulbar disorders. '
The general scral symptoms, which usually set in or the sixth to eight:r
day following injection, were usually preceded (for 2-3 days,' by e local reac-
tion in the vicinity of the site of inject--.n (in the buttock).
A lethal outcome developed in only one case of the encephalitic form.
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