A NEW METHOD OF SYNTHESIZING POLYMERIC N-VINYLLACTAM

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700230055-4
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: July 14, 2011
• Sequence Number: 55
• Publication Date: March 29, 1955
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/07/14: CIA-RDP80-00809A000700230055-4
STAT
Sanitized Copy Approved for Release 2011/07/14: CIA-RDP80-00809A000700230055-4
 Sanitized Copy Approved for Release 2011/07/14: CIA-RDP80-00809A000700230055-4
AM WM MOD OF SYNTHESIZING POL-IC N-VTh rLLACTAM
(Cecmient: The following is a translation of a German abstract
in Chemische Technik. Vol 6, No 11, Berlin/Leipzig, 1954, p 618,
based on the Hungarian article by R. Bacskai and J. Barabas
in Magyar Kemiai Fo yoirat Vol 60, 1954, published
pp 145-147.)
Polyvinylpyrrolidone (PVP) is an excellent absorbent of toxins. When com-
bined with other drugs it prolongs the period during which these drugs remain
in the body and thus brings about a considerable improvement in the specific
therapeutic action of the drugs. The technical preparation of PVP presents
some difficulties. An attempt to find new methods for the preparation of PVP
and its hcmtologs has resulted in the following simple synthesis of N-vinyl-5-
methyl-2-pyrroli-done from levulinic acid and ethanolamine:
Hydrogenation is carried out at room temperature and 10-13 atmospheres.
Purification of II can be carried out by distilling this compound in vacuum
(b pt 148-1550 at 5 mm Hg). Compound II is dissolved in benzene, then SOC1
is added slowly (dropwise) to the solution, which in the meantime is being 2
cooled pith ice and stirred rapidly. After this, SO and HC1 are removed by
boiling and the benzene is distilled off. Compound 2I II is purified by dis-
tilling it in a vacuum (b pt 102-70 at 1-2 mm Hg). Hydrogen chloride is
removed from III by treating this compound with a suspension of NaOH in ben-
zene. Compound IV is purified by subjecting it to vacuum distillation (b
pt 700 per [sic] 3 mm Hg). Polymerization of IV is carried out in a sealed
tube at 1000 after addition of 1% of H202 and lp of NH3. The polymer is
completely soluble in water, but differs from the monomer in that it is not
soluble in ether.. The physiological activity of the substance that has been
prepared is being investigated.
Sanitized Copy Approved for Release 2011/07/14: CIA-RDP80-00809A000700230055-4