SCIENTIFIC ABSTRACT GAUZE, G. F. - GAUZE, G.F.

• Document Type: CREST
• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R000514420005-0
• Release Decision: RIF
• Original Classification: S
• Document Page Count: 100
• Document Creation Date: November 2, 2016
• Document Release Date: August 23, 2000
• Sequence Number: 5
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

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"Soi.ie E'eatur--zl In The Evolution Of Integments In Frest-,-'e,'atcr kr,~'ysspd Py Killini;
Acticn Cf Cr-tically lEFomc:ri(- OrgEmic ~~cids. InstJtut(.~ Of ZooloCy, 1-bscov., Statc Vniversitjy.ll
by Fauze G. an,.~ Swaragodv-I, '111. F.
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IITI~e zounl hpalin;~ an,, a7-e." (-. 1'29) by n F. lause *
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L. -f
SO: Adyances -ja k!-%Wrn Biolo (Uspakhi 3ovzralrermoi Bioloric) Vol. XII, No. 3. 1940

GAUSE, G. F.
"Frey-UIyssling, A., Submicroscopic Morphology of Protoplasms" (in Geiiran) (P. 572)
by Gause. G. F,
SO.- Advances in Modern Biology, (Uspekhi Sovremennoi Biologii), V01- XIII, No- 31 19hO

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"The problela of stabilizing selection," (p. 193) by G. F. Gimse.
SO: Jourml of General Biolomr (Zhurml. Obschei Blologii) Volim II No. 2, 1941.

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GAUZE, G. F .
"The reaction of living -,mtter to external effects. Denaturation theory of tram= and
irritation." (P. 301) by D. N. -Nasonov, V. Ya. Aleksandrov, Q.-F, Gaigge,
SO: journal-ag Ggne;:Al, BIolo-zr (Zhurnal Obschei Biologii) Volw,,ie II No. 2, 1941.

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f;vlaf j;Ud 3, 217-1609i1); cl C. A. 34.
be MUlly 44 the ITIMIL41111111 Ol V01tiOlli 1401. fit 14 file
=-c5 by how they Ate kradurraird by Optical "''l" of cau., ".11lool I., &A"olit'd It" hy tile
"of varsoxii sutntancrat it prar%cuted as a methort Of "Nuniption of a freeptive %till,t4twit divrMy Atlectett by
investitat an call"I d!vw.e1'ic andlylis. The methail i% the 2 isomrt%. The coefl. Of relative toxicity Of the 2
applied in the Stittly 4 (1) tile MCVhAjlj%rr rj Ingle, fartion imatirri Of tartaric 4641 in-ciiiie, front I in 1.303 when
(2) The evolUtion 14 the ntfvtxl% %Y4tem. (3) that me' One Itia1w, front the lawfoloa I'l tile fiAllel through the
clatialit" (it lite v2riout phriol. funitiotall in proluzoo rill killing Aillon. in tilt towel
exhitit, In'. "In, I., 1w tile tit lachw, illilt If ;air t,-nuutm ill the
The 2 optical 6onirri of it Initte %ule,tiancr may
differarrit deKtrm of toxicity ithe natuml i,.(xncr bring; nume 2 isomers, "hile. in fill- hight-f ('wiril, It it title fit (A' tor%
toxic) but jxwrx4 the name mech3n6tra of toxic action which differ in the :1 i-turr~. It I, itigarted that the
at judgiril by the identity Of the "Lition of Inrcaj: fWari of the ]it type are III~ which airt moily on the
Ing toxicity to torten. and be the itlenti(y of the .4all'19ce Of tirlianions. anil file favlor~ of The 2nd tM,
thote which act intrinally. The problem of the mode of

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The study of the toxic action of nicotine in animd4 of
variously develovird nervous ~yitetn; lsointi. to the ab. roe
-raccotallpatially%riecificrelvtonv %tilmiAnce in Protozoa
Coclenterala, T-jilicil.46A, kotatori.t 4nil NctocrtinrA: Cies
.Ind the preien#v of sipch a ul,itatue in Antirli-lik. free
H Chn lognathis und Verichraw lit Aithrol"lit it is
abicalt tagain. it cl-imli.irion Of iti di,tritaution with thAt
fit acct&holinc in Ifilyercut grouli% of allittwk leads tit 'see
Naltnificallt tIAtA on thc rvolullon of tile nvtvou% %Y%tem.
rhe r"vi-tive -uleitan,v in tod-thir r-i-ninx Olt- vatic
Q~T CIOC tdAtiOn tit the receptive uibstance (,it cheill.

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btv-e controlled by the cn,loplastn. Of the 2 t~omrra I)( floe
cinchonitic ottly tile IrvototAtory howed the ipecifi,
c" power fit %timulatine ciltarv
--I -1- 0 - 1--l-o ti- I v ilk .4 o
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,cojo~?icaj ajantivity." (p. 227) by F. G
SO: A-1-7ances in Yodern Biolo- (TTsvekhi Sor-enennoi 9!olo-le) Vol. XI-T. No. 2, 1-9/A

f".~Usg, 1,. 7'..
(7,eorr_aT)vjjcp_l reaularitio-9 In varia'ilitY Of' or7a_n4sVl,.'T (F. 5-38,
"Lifrdne, E. T., Darwiniqr, anl
R.,v. !"! r. 7. lalv-. 10 (iT, - .10. 3, 19111
�0: '.k~vnnc_ ~s --'n Y64p, v:,. Bio _ g7 ;n0l.&J r)ovremt%nnol TiiolO'lle) Jol. '.(IV ,

" AU'~7 E 3G. :.
"on the in7erse Relation Between Acq7iired and inherent Pr-)nertics of OrCanismr,,"
Dokl. A': rS.'Z, 30, -~o-3, 1o,41

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GAUZE, G. F.
"The Struggle for E~xistance and the Problem of Wound Healing." (p. 153-~) by Gauze, G. F.
(moscow)
SO: Advances in Modern Biol2EI (Uspekhi Sovremenrioi Biclogil) Vol. IL~, No- 5, 191.3.

GAUZE, G. F.
I'The Prcblem of Freezing." (P. 571) by Sheinis, V. N. (Moscow 1943, 96 pages)
Reviewed by G, F. Gauze (11'oscow)
SO: Advances in Modern Biol2u, (Uspekhi Sovr~mernoi Biologii) Vol. 16, no. 5, 1943.

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un .;th3 " -*0
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teria was Lwlmrd which proluces a hillicab un mow" "An. to dryucm at 37-141", (Ii-fror the try rr.-Illuc in a "of
00 1 Crptj gx-1peptide. in. Thk -uL%I&a* h JcAj- anian tunt. of Warm ale. on & Water luth at 40 6'. ashl/
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for Larce-wale lic'.1ii'mou t4 grallik~idin "S" 16 dexcritri. Thor wtivot Principle ctytaililt. Filter and wozools the
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00 fcctiun. The "tell Nutctium C- iiindair to. thiough rAX filter. p~crptxmze 2 or timm times from the wetonc-
identical with. the stfAill of Dul.p%aud Lckongs to the B"d- water qcAn. With the charmial and wz--h ewh little with Purr 1190
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Culture
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and this sula. wess applied with tampons. Clotial frujus 7 woo
-
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=j::rsme infections of the hip o(
,
d
4100
0 an
on
rats hav Ing hip wannals infected
lialsectoriciaW
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at
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PH!W:uaftNqvj' trouncocci VA C. dithAeride. J. W. Ile"

no*

If Igoe

w

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u.i,-, ,.~ ,, ..
117'aria.+ic.-i and ':e-~md44-y A7.orif, 'A,-~ro-cc)-Ac Clr-nunisms" (p. 132) 'by lr~,uze, -. ~,'.
1 .1 .- I - - - . - I
. T
. I
SO: Advnces -,rt ::n(.iprn OsT)ekhd Hiol,qf-ii) Vol. Ito. i., i~,4c;.
I

y 3~r,,7e , .,)3 1 4-,# -e::)
'he olo ral 7ield" (P - 283) ?-ede7,.-cd F. C', c0-.7, Yl
(Us,,~ekhi Sovremenrici dolo~ii) "o. 2, 1~45
odern

"Gramicidin 'IS" if (P. 345) by Gause, G. F.
SO: Advances in 'fodern Biolomr (Usnehhi Sovremennoi Biologii) Vol. Y.X, 110.3, 1945.

GAUZE, 0. F., AND Yr.. T. KOROBKOVA
"Action of Streptomycin on the Plague Bacillus and Cholera Vibi-io,"
ZhNEI, 7, 54, 1946

T -7.--. cv-.
11 W 0 0
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0 04
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c 0. Gauze (Ac3m]. M"L !ki..
%fowow).
067-71(IM); cf. C.A. 60.
64001pej ryamems. "Ird fruill a %,it
111 South RU BMW on & Vaster W 11milulnit Imt Imls.
wulb baw (1) woo wwnt. N a neutral l1wdium coats.
In 1. ad topwattes) ptptcmrA k 13, sidemg to, N&CI
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static -.vmm. of It Its amit"i booth (in p,p.nk.) *its.
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of ntr stnJo) too- Aml. I U1. IY*
phostems A tw 11, owl Ejel. oWs, A101.4-Z 10111).
Che"UAIMAIWulk. ;,oWTr IBM: ubwtvvd aphi-A wplicrosiLt
Ill $%tit* illift-iftl 010ASIOPA. JSPIPW. tit WhIell It Olkil ISISMY
Aim-!
It I"kh. m rdro. Time mauto 1'. SJOWNS Vvir.milit-6.1kU. is
iihm to the orgailum. imid JA~Jlm to IL 11.
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... -,-, P F
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,,ploIc-gical action cf irbidim." (.. 433) by Gtosil, G. F.
.0 -
"L',Cl: Advances in ',bdern Biolc;--y (Uspekhi 3ovremennol E-iolozie) IV 1. ~',7TJ, NO. 3, 19-~6.

CAaUzz.-, i, L
fIlAkarstvennyye veshohestva mikrobov (Microbial Medicinal Substances),
publlshe,' by AM, SSSR, Moscow, 1947
- 'i .- -7--- -
- :' - --- - 5 'T

C,A=. 0. F.
*Recent J'uccesses in the Study of Antibioticsp* ZhWl, 3, 6, 1947

"Soviet Cramicidin and Now Antibiotics," in the bookt Antibiotiki., 12-14,,
1947

USSR/Medicine - Antibiotics mar 1.947
Medicine - Ophthalmology
*Antibiotics and Optical Activity," 0. F. Gauze,
8 pp
*Uepekhi Covremennoy Biologii" Vol XXIII, No 3
Discusses optical Inversion of the penicillin mole-
cule) the streptWcin molecule, and gramicidin S,
the biological activity of optical isomers, and
the restraining action of inverted molecules on
enzymatic -processes.
10'T50

GAUZE) G. F. (Prof)
The Problem of Antibiotics in the Light of Theory
Ywtnik kk Mod Nuuk WSR, No 1, 1948 -

1.
A &CASP I., LA
00 4
D*W9 as.d WaIWM farms of Bacillud m
"me pkyllol*ca
F,
G. 11, 134-9(1949).-The
do tam Mot D. the dextr2l
form (11) was found inOZ;TV20 I,, Russia and
g=hu "ted In only 2 (Gagry. 65%; Sukhumi. M~ 1.
in Bmil, counts showed IN)- I in'r7.
100% It In 3; morr 12 than I In 3. Im In 2;:~~. 0., f
factor is the faster growth rate of 1. Av. colony diam. for
18 Russian and 3 Brazilian cultures. at 24 hrs.. was 108';
ueater for I than For It. Accionling to Alpalov and
Nastyukova (C.A. 41l 8M), I-quium-rine inhibits I
more actively than U. and J-quinac-fine Inhilwits It morr-
thanI. Tests with 0.0038% inhibitor in 1xitato-agnt
cultures revealed no such selectivity. J. F. S.
V tin,
Q 1
JP_
S I A64TALLUNGK&L tOTCRATURt CLA&UPICAtION
81 41C.-
"&Took%:-
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IV
to

USM/Madicine - Microbiology Wr/Apr 49
Medicine - Bacteria, Istrcoides
"Tendencies of Bacillus Mycoldes to Spiral to
the Right or Left," G. F. dauze, Inet of
Jklarla and Nled Parasitol, Acad Mad Sci USSR,
6 pp
"W"iologlya" Vol XVnl, No 2
Lift-opi.rat"m R. raycoida*;are;-'fou:nd In central
UW, right-spiraling bacteria in Trans-
caucasus region. South American soila(Br~ztl)
contain zany right -spiraling forms rarely
found in. lurope. Left-develop faeter than the
44/49T81
USM/Medicine - Mc~ro- Mar/Apr 49
biology (Contd)
Y~j
rigbt-opiraling bacteria due to relatively
weaker physiological condition of the latter.
Both'r1ght- and left-spiralijig B. mycoldes
are inhabited by both optical iijaners of
atabrine. Submitted 24 Mar 48.
44/49T81

PAmft of recoM f~cb on antiblotka. G. P. GAuze
lAced. Aled. S6.. Mosam), MiAobi6lo
IRML-13 flitmims. julun F. iWilr-I
uss~
oct-J-1

C- h \,) z- G, (~- - F
Hkusz, G.F.
--- - of microorgaulam13-
Gertain Droblems in geography
no.2:263-272 Mr-AP 150.
U;3P.90vrem.'biol. 2-19 ~ :
(r,,-INL 19:2)
1. Moscow.

GAUZZ, G. 1.
Therapeutic action of antibiotics according to the Pavlovian theorys
Bratial, lek. listr 31 no. 11-12 1081-1087 1951. (MML 23:1)
1. Of the Laboratory of Antibiotics of the Academy of Medical Sciences',
USSR.

AnUbioLics
zci*ect of al')ozTrein upon bact-~ria. !Tovosti r.-.2d. no. 23,
Unclassified.
9. Monthly List of Russian Accessions, Library of Congress, 1953.
?~2

GAUZEJ G. F.
"Recent USSR Work in the Field of Antibiotics.," Znarziye Publishing House,
Moscow, 31 pages, 1952
Translation W-25279., 10 Feb 53

GAUZE, G. P.
%ramitsidin C i egO Drimenie Grainicidin C and its use Moskva, Nedgiz, 1952. 152 p.
(Biblioteka praktich~skogo vracha)
1. Antibiotics.

GAUU G.F.
Selective action of antibiotics In the light of commarative bio-
chemistry. Uspekhi Boyremennov Biol. 34,1354-66 152. (WRA 5!12)
(CA 47 no.14:7036 153) 1

USSR/j3iology, Agriculture - Anti- Jun 52
bioti:~s, Plant
Diseases
"Use of Antibiotics in Combating Plant Dis-
eases," T!rPf G. F.-Gauze) Lab of Antibiotics,.
Acad Med Sci d
Priroda" Vol 41 No 6
PY 105 -3-07
Describes N. A. Krasillnikov0s, work on the
resorption of penicillin by lettuce through its
rrot system ("Dok Ak Nauk SSSR" Vol 79, No 5,
P 879,1951); the use of griseofulvin, an anti-
biotic which is effective in combatina fuacus
229T6
diseases of oats, lettuce, and tomatoes; Kra-
sil'nikov's results on cotbating bacteria! d4-,:;-
eases _f cotton and citrus plants with anti-
biotics.
229r6

GAUZE.7 -).F.
Lektsii uo antibiotikam (Lectures in
antibiotics). Izd. 2-e, pererabot. i doo. ',.:oskva,
1.'-53. 251 p. (Alrl-ad. med. nauk- S3SR).
a)- '-!orithly List of Russian Accessions, Vol. 7, No. 5, Auf,,ust 1951

I
USSR/Medic.'Lne C-ancer Research
Card 1/1 Pub 122-5/14
FD-1520
Author Gause, G. F., Professor
Title Concerning effects of antibiotics on the growth of malignant tumors
Periodical Vest. AMN SSSR, 4) 29-34, Oct-Dec 1954
Abstract Although no antibiotic has yet been found that would have practical
application in the treatment and prevention of cancer in man, experi-
mental data now on hand is Interesting enough to encourage further
research. The trend in recent years consisted of search for antibiotics
that posses specific Dower to check aerobic glycolisis and that are able
to suppress the growth of malignant tumors. Difficulties encountered so
far have been due to the fact that spect-fic biochemical peculiarities of
cancerous cells are not well known. When that is discovered it may be-
come possible to develop antibiotics with specific action on the bio-
chemical process peculiar to those cells. Graphs.
Institution Institute for the Investigation of New Antibiotics, Academy of ~Ledical
Sciences, USSR
Submitted

GAUZE,, G. F. Dr. Biol. Sci.
"Recent Studies on Albomycin, a New Antibiotic,," published in British Medical
Journal, P. 1177, 12 Nov 55
Gau2e was a member of the team of six Russian doctors who recently
visited the United Kingdom.

GAU23, G. F.
Certain problems in the Plasfitfication of Actinomyces. Kikrobl-
ologits 24 no.1:103-113 Ja-F 055. (WLRA 8:4)
1. Institut po izyokanlyxi novykh antibiotilov Akadomil moditain-
skikh nauk SSSR, Moskva.
(ACTINGHTCES,
classif.)

GAUZE, G. F.
"The Effect of Antibiotics on the Growth of Viruses and Malignant Tumors"O
a roport presented at the First All-Union Conference Devoted tothe Clinical-
Experimental Study of Antibiotics, Moscow, 25-27 April 1955, Antibiotiki, No 1, 1956

USSR/Tum.ors u-4
Abs Jour : Rof Zhur - Biol., Ho 6, 1958, No 27T70
Author : Gauzot G.F
Inst 2 Not-GIven
Title s On the Effects of Antibiotics on the Growth of Viruses and
Malignant Tumors.
Orig Pub : V sbo Antibictiki. Eksparia.-klinich. izueh. M.p 1956,
103-109
Abstract : Of the numerous antibiotics known at pronent, only 7 have a
weak antiviral activity; erlichin, achromoviro-mycin, netro-
poin, a crystalline substance from Proactinomycos formion.,
cardicin, elonin and viscosin. No TofA'i-on's-h'i-p-b`otwoon anti-
bacterial and antiviral activities of these antibiotics, as
wall as between their efficacy against certain viruses in
vitro and in vivo was established. There aro no thoorotioal
grounds wkde-W -may indicate possible methods of search for
antibiotics possessing antivirus activity, hanno, such studios
are entirely Impirical. A number of antibiotics with antinoo-
Card 1/2
the Jk-ray therapy oI* n:Ltragon nustara komo2.cn1no)*

USSR/Microbiology. Antibiosis, ind 3ymbiosis, F-2
Antibiotics.
Abs Jour : Ref. Mur-Biologiya, No 1, 1957, 515
0
Author :-S. F.-Gau-ze, 0. L. Popova, G. V. Kochetkova.
Inst
Title New Method of Selection of the Producer
of Albomycin
Orig Pub : Antibiotiki, 1956, 1, No 1, 18-20
Abstract : 1,11hen a suspension of spores of Act-inomyces
subtropicus, the Droducer of albomycin,
is-.subjec'ued to uitra-violet li-ht, in
the subsequent selection it was not
possible to isolate strains with a greater
productivity of albomycin (1) then those
isolated from the initial culture. No
results were obtained also in the attemDt
to derive a more active variant by
Card

USSR/Microbiology. Antuibiosis, and Symbiosis, F-2
Antibiotics.
Abs Jour Ref. Zhur-Biologiya, No 1, 1957, 515
Abstract subJecting the suspension to the action
of 1 . In view of the fact that 1
contains iron (11) and actinomyces are
highly resistant to 11 in the nutritive
medium, an attempt was made to find out
whether any connection exists between
the increased resistance to 11 in the
medium and the increased synthesis of 1.
In concentration of 0.02 to 0.085' of
FeSO this connection was not established.
Pur~Lr, the effect of Streptomycin (111)
on the development of actinomyces in a
solid medium was studied. In concen-
trations of 111 in the medium equal to
50, 100, and 200 garuma/ml a single
Card 2/3

USSR/Microbiology. Antibiosis, and Symbiosis, F-2
Antibiotics.
Abs Jour Ref. Zhur-Biologiya, No 1, 1957? 515
Abstract colony has C-3rown from 1,000, 20,000 and
40,000 spores respectively. Streptomycin
resistant variants w1iich freely develop
in 150 gamma/ml varied considerably in
their morphological and physiological
properties. A change in'the color of
the mycelium was observed in 15 cases
out of 200. In a amall number of strains
of 524 streptomycin resistant forms the
formation of 1. exceeded by 150 to 200
percent the formation of 1- from the
initial culture, and this index was
maintained by a number of generations.
Card 3/3

'r - F-
USSR/Microbiology Antibiosis and Symbiosis. Antibiotics F-2
Abs Jour : Referat Zhurn - Biol. No 16, 25 Aug 1957, 68473
Author : Trenina, G.A., Ganze, G.F., Preobrzhenskaya, V.F.,
Brazhinkova, M.T., _Marova, Yu.A.
Title : Antivirubin-Antiviral Antibiotic Formed by Actinomyces
longispororuber.
Orig Pub : Antibiotiki, 1956, 1, No 4-9-13, 62
Abstract : The morphologic, cultural and biochemical indications
are stated for the most productive strain No 8173, in
relation to antivirubin (I), isolated from desert soils
of Kara-Kumov. The antibiotic accumulates mainly in
the actinomycete mycelium, The optimal medium for for-
mation of I is nutrient agar, containing Chottinger
broth (30 mg % amino nitrogen), 1% glucose, and 0-5%
sodium chloride. The fullest isolation of I is obtai-
ned by steeping the agar nutrient medium an which the
.product was cultivated in strong acetone and subsequent
Card 1/2 - 33 -

USSR/Microbiology - Antibiosis and Symbiosis. Antibiotics F-2
Abs Jour Referat Zhurn - Biol. No 16, 25 Aug 1957, 68473
evaporation under Nacuum. I is.obtained in the form of
a dry preparation containing 800 antistaphylococcus units
per mg. I appears as a bright-red pi(pnent with properties
of a dye. Blood serum only insignificantly inactivates
the antibiotic. The study of the spectrum of the antibac-
terial action of I demonstrated that it has a selective
action on staphylococci, Bacillus mycoides and hay bacil-
li, weakly inhibits growth of intestinal bacilli and
Candida albicans. I inactivates the tobacco mosaic virus
grippe virus, smallpox virus and does not act on bacterio-
phage.
Card 2/2 - 34 -

EXCERPTA 1,2DICA Sec.4 Vol.11/4 1!:d.!:icrob. elCe. Apri158
807. FORMA71ON OF COLIMYCIN IN CULTURES OF ACTINO'MYCES FP-kD-
IAE VAR. SPIRALIS (Russian text) - Gauze G. F. , Xochetkova
G. V. , Preobrazhenskaya T. PT.-5-Fd-P-L1-vzner N. S. inst. for
Res. on New Antibiotics, USSR Acad. of Mod. Sci. , Moscow - ANTIBIOTIKI
1956, 5 (5-8) Illus. 3
The coli mycin -producing A. fradiae var. spiralis when grown on mineral agar does
not colour the medium. The substrate myceliurn is at first yellow, then orange or
reddish-brown. On organic agar the substrate mycelium is at first yellow, then
yellow-brown. An aerial myceliurn appears late and is white or lilac-pink in col-
our. Sporangiophores are spirals, and spores are elongated. It inhibits the growth
of M. aureus, B. coli, Aerobacter aerogenes, B. mycoides, B. subtilis, Can-
dida albicans, etc. It forms two kinds of colonies: white and more active pink.
Maximal colimycin formation in media in depth cultures is accompanied by autoly-
sis of the myceliurn and by an increased concentration of aminonitrogen in the nutrient
medium. Addition to the medium of starch, glycerin, glucose and fumaric acid in-
creases colimycin formation. Lactic acid depresses it.
Svinkina - Moscow (S)

-GAUZZ, G.F.,professor (Moskva)
Study of the qualities of the now antibiotic albomycin. Test.
AMN SSSR 11 no.1:21-26 #36. (MLRA 9:5)
1. Is Instituts p0 *skanii novykh antibiotikov ANN SSSR.
(AZITIBICTIGS
alboarcin., pharmcol.)

USSR/Virology - Pacterial Viruses (PhaGe).
Abs Jour : Ref Zhur Diol., No 6, 1959, 23781
Author : Gauze, G.F., Kochetkova, G.V., Preobrazhenskaya, TP.,
.9', Sveshnikova, X.A., Popova, O.L.
Inst : -
Title Actinophages as Test-Objects in a Search for Aiiti-Virus
Antibiotics.
OriG Pub M. L;iC.;iyeny, ipiderdol., mikrobiol. i i=runol., 1957,
1, No 1, 53-58
Abstract 71ie ability was studied of 1000 cultures of Actinomyces,
isolated from soils of various geoaraphic locations, to
suppress four cultures of bacteria and six variovs Acti-
nophaZes, of which four were Polypha,,es. It was determi.:t
ned that about one-half of the tested Actinonyces are
able to suppress one or several Actinophages in the ex-
periment. ActinophaGes were suppressed by Actinomyces
with antibacterial activity as well as by Actinamyces
Card 1/2
USSR/Virology - Bacterial Viruses (Fffares). E
Abs Jour Ref Zhur Diol., No 6, 1959, 23781.
which did not possess antibacterial activity. It was
noted that Actinomyces able to suppress a corabination
of 4 ActinophaGes (No 2671, 2761, 250, and 3087) were
fOUILd rtost frequently; these ActinophaL;es turn out to
be most conveiieut test-object in a selection of Actino-
myces of cultures which produce antivirus antibiotics.
Ya-1. Rautenshteyn
Card 2/2
4

...........
JV
108 117"1(1956Y. --Cultures of Aclinamyce
growki onagzr in dftAT=t diIns.at 28' for 72 hrs.
cultures, while very active rigalasit normal
shwed that sonw
ve ag3lnst the s"alled albamy-
~-,xtaphylococcil, were inarti
-rei!stunt strains, rWle other cultim ~ vcd a ochavitz
such that b4th rtr?Arswtre attack4td~ The latter form gen-
*
J',
crated,not only albomyclu but another antibiotic factor
W h auld not'be WLited coavcntiofially. Stminn

F Jhcse~strafns'could preserve their aatiblotic cham~ttrlcitics
~cvgral yt;ivs..
x-&

14
-11 JI-V

GAUZI, G.Y.
~-
CF-ro-biams in cjassifyiqg~actinomycote antagonists] Toprosy irlassifi-
katsil 8kt'uOmlt~OtOV-aut89Olll8tOv- Moskva, Medgiz, 1957. 206 p.
(ACTINOKrG]ITALES)' (MLRA 10:7)

GAUzi-:-'p G.Y.-, KOCIMKOVA, G.V.; PiX4B.U:,.IMiSKAYA. T.P.; E-3,;
F.A.; POPOIA, U.L.
N
Mie use of actinophages in the search for antiviral antibiotics.
J. Hyg. Rnidem., Prahn 1. no.1:63-69 19,57.
1. Institute for Antl-~!)tics Research of the Academy of !Aedical Sciences
of the U.S.SeR., Moscow.
(ACTITTORYGNSO
actinoiahages, in research on antiviral antibiotics)
(ANTIBIOTICS,
antiviral. une of Petino-ohages in renearch)
CRACTTCRIOPILO-3,
nctinanhppe in resenrch on antivirol. antiMotics)

GAUS. G.F.
Soviet scientists; role in solving the problem of obtaining nev
antibiotics. Antiblottki 2 no-5:8-11 S-0 157. (MIRA 10:12)
1. Inatitut po izuskeniyu novykh antibiotikov AMU SSSR.
(ANTIBIOTICS, preparation of,
research in Russia on prod. of nev prep. (Rus))

GAUZZ, G.F.; PnOBRAZHENSKAYA, T.P.; KOVALSIXOVA, V.K. ILI IGHEVA, H.P.;
"ft~-~~YA, M.G.; LOMAKINA, U.N.; KOVSHAROYA, 1.11.; SHORIN, V.A.;
KUHRAT, I.A.; SHAPOYALOVA, S.P.
Crystallomycin, a new antibacterial antibiotic [with summary in
Nnglish]. Antibiotiki 2 no.6:9-14 ilD 157- (MIRA 11:2)
1. Institut po izyskaniyu novykh antibiotikov AHN SM.
(ARTIBIOTICS, preparation of,
CA(,crystallowein. prod. from Actinomyces violaceoniger Okua))
THOMYCHS
violecooniger, prod. of antibiotic cryiitFi11oaqcin (Rua))

USSR / Hlicrobiology. -Antibiosis and Symbiosis.
Antibiotics.
Abs Jour : Ref Zhur - Bioloaiya, No 5, 1959, No. 19478
7
Author : Brazhnikova, M. G.; Kovsharova, I. N.;
Gauze, G. F.; Sveshnikova, M. A.; Bob1cova, T. C.;
bliorln, V. A.; Rossolimo, 0. K.
Inst : 'Not given
Title : Cerulomycin, a Recent Antivirus Antibiotic,
Formed by Actinomyces coerulesceiis
Orig Pub : Antiblotihi, 1957, 2, No 6, 16-20
Ilbstract : A. coerulescens 1581,
which produc-7.-s the
antivirus antibiotic
cultured In flasks on
cePtaining 1.% soybean
-1
l
," glucose, 05" NaCl
Card 1/3
aerulomycin (I), is
swings In a medium,
flour or corn extract,
" CaC03. The
arid 0. 5'k
S-

USSR / Microbiology. Antibiosis and Symbiosis. F
Antibiotics.
Abs Jour : Ref Zhur - Biologlya, No 5, 1959, No. 19478
of 200 mg//kg. I possesses weak neutralizing
action on grippe virus in vitro and has little
medicinal value in experimental Srippe in-
fection. -- T. P. Vertogradova
Card 3/3

USSR/Virology - Bacterial Viruses (Phages)
Abs Jour Ref Zhur - Diol., No 19, 1958, 85-(65
Author Gauze G F , Kochetkova, G.V., Preobrazhenskayaj.P.,
*U_tr__in-n__'_T'e-S., Sveshnikova, M.A., Popova, O.L.
Inst ~0" 1z"Y"I"frPlyt,
Title Studies of the Suppressive Effects of Actinomycetes on
ActinophaLes.
Orig Pub Mikrobiologiya, 1957, 26, No 6, 729-735
Abstract Of 9 actinophages isolated from the soil only 2 were dis-
tinguished by specificity of action, while the others
were polyvalent. Comparative studies of the antiphage
and actibacterial activity of 1000 strains of Actiaomy-
cetes showed that of 546 strains which suppressed bacte-
rial growth, 331 also suppressed actinophages (under con-
ditions of interaction with a culture), and of 454 strains
which did not suppress bacteria, 247 also suppressed ac-
tinophages. Of 578 cultures of Actinomucetes with
Card 1/2
3

USSR/Virology - Bacterial Viruses (Phages)
Abs Jour : Ref Zhur - 13iol., No 19, 1958, 85765
E.
antiphage activity, 279 (48%) acted against 1, 147 (21%)
acted against 2, 85 (15%) acted against 3, 40 (7%) acted
against 4, 21 (4%) acted against 5, and 6 (1.9%) acted
against 6 ddfferent phages. -- Ya.l. Rautenshteyn
Card 2/2

USSR/Microbiology - Antibiosis and Symbiosis F-2
Antiobiotics.
Abs Jour: Ref Zhur - Biol, No 18, 19587 81441
Author Gauze, G.F - ------
Inst
Title Geographic Distribution of Microorganism-
Antagonists.
Orig Pub: Uzpekhi sovrem. biologii, 1957, 43, NO. 11 46-54
Abstract! The author invites the attention of investigators
to a very important question from the point. of
view of seeking antibioticsq but one to which
little attention is paid: the geographic dis-
tribution of anta onists (mold fungi, bacteria,
and actinomycetes~ andmakes some general
deductions. Bibl. 14 refs.
Card 1/1
20

, ,GALU23, G.F., profeesor (Koscow).
luropean conference on antibiotics. Prlroda 46 no.1:111-112 Ja 157.
(Kilan~.~ntibiotics--Congresses)

GAUZE, G.F., professor.
*ffect of antibiotics on viruses. Pr1roda 46 no.3:98-100
Mr '57- WaA 10-3)
1. Inmtitut po izyskaniyu novykh antibiotikov Akademil meditolnekikh
nank SSSR (Mookva)
(Antibiotics) (Viruses)

USSR/Microbiolo6y - General MicrobioloEg. Variability F
and Heredity
Abs Jour : Ref Zhur Biol., No 22, 1958, 9929o
Author : Gauze, G.F., Kochtkova, G.V., Vladinir,,va, G.D.
Inst ; AS USSR
Title : On Biochemical Mutants in Yeast Cells with Impaired
Oxication.
Orir, Pub : Dokl. AN SSSR, 1957, 117, 110 1, 138-141
Abstract : ThrouGh the action of trypaflavine (3,6-diamino-10-
methylacridine chloride), capVior or ultraviolet rays
on the plicated form of Saccharomyces cerevisiae, Ros-
tov breed, strain AN-2, biochemical mutants with impai-
red respiration were obtained. This property is firmly
transmitted to future generations and is retained with
reseedinGs in the course of many months. The iupairneut
Card 1/2
19 -
USSR/MicrobioloGy - General MicrobioLia - Variability F
and Heredity.
Abs Jour Ref Zhur Biol., No 22, 1958, 99290
of respiration is accompanied by irreC;ular chani~es af
aerobic Glycolysis: in certain cases the intensity of
Glycolysis increases and in others it decreases. For
rapid differentiation between normal cells and uutants
with, impaired respiration the method of specific stain-
inG of colonies oh wort-arar, with the help of the leu-
kobase of methylene blue, was used. Biochemical mutants
of Yeast cells differ from normal cells in the same way
as hi u and animal cancer cells differ from the healthy
cells of an orpnism. The mutants obtained can therefore
be used as test objects in investi[,,ations on anticancer
antibiotics. -- L.G. Azova
Card 2/2

Country U38R
Catc.rr.cry Microbiology. Antibionth qW byrnbi,3alsi. Antibiottun
Jour *Ref No 23, 953, ,qo io~696
Auth~,r
,,-F.' Kochet1wva,0. V. VIrdirdrova G. 5.
Tn8titut . AorAdJW of Scleno(91) USSR
Title Biochemical Rutuats Of Itaphylvaocci With Damazed
Oxidation Systems as lie-iT-Obiw-t!i in the Search ror
canoer kntibiojUG5.
Orir; 1,ub. Do,:1 . All MR, 1957, 117, i,'o 4, 720-722.
11~'atr-'Ict :Througt- ultrv-violet Jrradirticn of r. stridn of Staph.,--
coocun oLuraus three iqutantn visre obtuinad ihioh
Uff;iQ-Ti~m- the original in thnir slou growth, Intense
pi6rzmnta+iol er)d ionaidora'bla reduction in reepIrr-tion
(40-60 loorcurt compared vilh the normal). &uah r=tantn
aro sizdlar to c&neer colls, in whioh imp&~rmnt of
oxidation is aloo, found. It has beer. shown that poni-
cillin and straptomycin auppress the Lrrov+,& af the
original a-trains and mutants, vhorer. ilt~y-ir, v.'~,nh
deprasaaa the 6-ro-Ath of baoteris. orly in the prsa6nae rf
oit~-gen, aots on the original strain ewd does not check
the growth of mrtanta. In consideration of the similari~
C a d:
1112.
F-21

Country
Category
AbS, joUr Raf Zhur-Biol., No 23, 1953, rio 103696
Author
Inatitut.
Titlo
F
OrIS Pubi
Abstract :between the mu-tents and qkncer calla from the poirt of
(Gont.) view of impairment, of oxidation, the authors attupts4
to find antibiotiom wbich would act 9816CUTOly OD
calls with impairment of oxidation and would not act
on calls with norml respiratory apparatuses. Among
2500 cultures of actinamyc*tes freshly Isolated from
soil, 60 cultures were fomnd which possessid a
selactiTs, effect on the xUphylococoun =utzwta with
impairment of oxidation.-G. P. Y'laina.
Card: 2/2

GAUZE, Gno 'rpi;r FrAntmovich; HISIMSTITI, Tn.11., otv.z-td.; A!;ToIITUI,, L.D.,
"j4dAzd-va-, TIOYTCRMVA, N.D., tekhn.red.
[Ways of searching for new antibiotics] Puti lzyikrpiin novykh
antibintikov. 14)nkvn, I7d-vo Aknd. nauk SSSR. 1958. 171 P.
0-11RA. 12:1)
1. Chlen-korrespondent AN SSSR (for Mdsbustlln).
(AlFrIlBIOTICS)

GAU29, Georg;Ly.-Frantauvich; SHORIHO V.A, red.; ZMIAROYA. A.I.,
-, - .-Waui.rod.
(Lectures about antibiotics] Loktaii po antibiotikam,
1%d-3, dop. Honkva, Gos.izd-vo med.lit-ry, 1958. 354 p.
(MIRA 1):4)
(ANTIBIOTICS)

GALTZE, G. F. ioscow, USSR.
M
"Some Biochemical Foundations in the Search for Anticancer Antibiotics."
Report submitted I D IV Intl. Cong. of Biochemistry, Vienna, 1 - 6 Sep 1958.
0

USSR/General Problems of Pathology - Experimental Therapy U-1
Abs Jour t Ref Zhur - adl,, Noi 181, 1956, 84877
Author : Gauze G F,
Inst : Academy o edical Sciencos USSR
Title : Certain Theoretical Problems in the Search for
Anti-gancer Antibiotics
Orig Pub : Vestn. Akad. med. nauk SSSR, 1958., No. ls 37-41
Abstract : Starting with the supposition that the metabolism
of cancer cens is charac.terized by heriditary distu-
rbances of the respiratory apparatus ZT-e, of the
cell's7J, studies were made of the possibility of uti-
lizing as a test-object for the selection of anti-
cancer antibiotics mutant strains of fungi and staph-
y1ococci with attenuated oxidative processes. Follow-
ing the action-on cultures of Saccharomyces cerevisiae
of trypallavin,, camphor, or ultraviolet radiation, or
the action of ultraviolet radiation on Staphylococcus
Card 113 nureus cultures, a number of strains were obtained

USSR/Goneral Problems of Pathology - Experimental Therapy U-1
Abs Jour Ref Zhur-Biol.,, No. 18,, 1958, 84877
Abstract with inheritable disturbances of the respiratory
processes. The mutanto did not oxidize leukobase
to methylene blue. These mutant strains were used
(0.F. Gauze, G. F, Koahetkov, 0. B, Vladimirova,
1957) for the study of the properties of 2500 cultu-
res of various actinomycetes-isolated from the soil.
seeded on agar, were transferred in
1he cultures,
two days to suspensions of mioroorganisms of normal
respiratory functions or with disruptions of same.
It was found (T.P. Preobrazhenskaya, Ye. S, Kudrina)
that 53 culturea suppressed the growth of the mutants
with altered respiratory functions but did riot in-
fluence the other microorganisms. The larger part
of the cultures which were active in relationship
to the mutant staphylococci showed no effect on the
mutant fungi; of these, ton cultures in experiments
in vitro suppressed the ascitic cens of the Ehrlich
Card 2/3 carcinoma. 1, certain portion, however, of the
22

GAUZE, G.F., klJDRM, Ye.S.9TR',9KINA, G.A., TOROPOVA, Ye.G., V-YSHEPAN, Ye.D.
Formntion of a new antibiotic actinoidin in cultureB of Pro-
actinomyces actinoides [with summaT7 in Englishl. Antibiotiki
3 no-1:51-55 Ja-F'58 (KIILA 11:5)
1. Institut po izyskaniyu novykh antibiotikov AMY SSSR.
(ANTIBIOTICS,
actinoidin. prod. by Poractinomyces actittoides (Rus))
(NOCARDIAR
Proactinomyces actinoides, prod. of actinoidin (R6))

BRAZHNIKOVA, M.G.; US.PENSKATA, T.A.; SOKOLOVA, L.B.; PRNOBRAZHENSKAYA, T.P.;
GAUZE, G.F.; UKHOLINA, R.S.; SHORIji, V.A.; ROSSOLIMO, O.K.; VKRTO-
GRADOVA, T.P.
New antiviral antibiotic hellomycin. Antibiotiki 3 no.2:29-34 Mr-Ap
158. (MIRA 12:11)
1. Institut po lzyskaniyu novykh antibiotikov AMN SSSR.
(ANTIBIOTICS,
heltomycin, prop. from Actinomyces flavochromogenes
var. heliamveini & antiviral properties (Ras))
(ACTINOMYCES, metabolism,
flavochromogenes var. heliomycini, holiomycin sy-n-
thesis (Rue))

G.AUZZ, G.F.
Symposium on the biochemistry of antibiotics at the Fourth
International Congress of Biochemistry. Antibiotiki 3 no.6:
117-119 N-D 158. (MIRA 12:2)
(ANTMOTICS)

GALTU, G.F., IVANITSICAYA, L.P., VLADIMIROVA, G.B.
Biochemical mutants of some bacteria with impaired oxidation
[with summary in English]. Izv.*An SSSR. Ser.biol. no.6:719-725
H-D 158 (MMA 11: 11)
1. Institut po izyskaniyu antibiotikov Akademii meditsinskikh nauk
SSSR, Moskva,
(ESCHERICHIA COLI)
OXIDATION, PHYSIOLOGICAL)
BACILWS MYCOIDES)
I

Prof.
WON---NMW
Some theoretical problems in finding anticancer antibiotics, Vast.
AMN SSSR 13 no.1:37-41 '58. (MIRA 11:2)
1. Institut po isyeksaiyu. novykh antibiotikoy AMU SSSR, Moskva.
(ANTIBIOTICS
anti-oancer, theoretical study)
(CYTOTOXIC DRUGS,
antibiotics (Rus))

AUTUORS: Gauzey, G. F. , Ivanitskaya, L. P., 20-1-53/58
Vla irova,-G. B.
TITLE: On the Cytochromic System of Biochemical Mutants of
Bacterium coli and Staphylococci With Disturbed Oxidation
~o tsitokhromnoy sisteme biokhimicheskikh mutantov kishechnoy
palochki i stafilokokkov s povrezhdennym okisleniyem).
PERIODICAL: Doklady AN SSSR, 1958, Vol. 118, Nr 1, pp. 189-191 (USSR)
ABSTRACT: Such mutants of microorganisms may be considered micro-
biological equivalents of cancer-cells and may serve as test-
objects in the determination of cancer-inhibiting anti-
biotics. The author3 wanted to produce mutants of Bact.coli
with a hereditary disturbance of the respiratory apparatus.
Slowly growing mutants were obtained by ultraviolet radiation
of the strains 5383 and 5375 with a dose which almost killed
all bacteria. Other analogous mutants were produced by the
influence of urethane upon Bact. paracoli. This substance is
highly cancerogenic toward the cells of higher organisms and
easily causes cancer of the lung (reference 1). In individual
rare cases mutant forms developed which after further re-
inoculations hereditarily conserved a retarded growth and a
Card 1/4 disturbed oxidation. Table 1 shows that the Bact-coli=

On the Cytochromic System of Biochemical Mutants of 20-1453/58
Bacterium coli and Staphylococci With Disturbed Oxidation
mutants had only 45 and 35~ of the respiratory activity of the
initial culture. The activity of the urethane-mutant of
Bact. paracoli amounted to 28~. Table 2 shows that the
respiration in these mutants is less suppressed by cyanides
than in normal bacteria, as it was proved by the authors
(reference 3) for Staphylocoocus aurcus'. This Eive rise to the
assumption of a disturbance of the cytochromic system in "he
mutants. The cytochromes were therefore investigated with the
microspectroscope by Zeiss (Tseiss). As figure 1 shows, the
initial strain of staphylococci (reference 4) has 3
characteristic absorption bands in the spectrum. In biochemical
mutants the wide band of the b 1 cytochrome can no longer be
determined. In the mutant of Bact. paracoli the dama~~e of the
cytochromic system is of another nature. In the initial culture
exists a wide cytochrome-b 1- band and 2 narrow ones (a and
a21 fieure 1). The biochemical mutant insiead of the b 1-band
shows 2 distinct cytochrome-bands at 555 and 565 m,44,. Besides
a wide cytochrome-band is here seen at 600 meLA. and the weak
Card 2/4 a2-band hitherto seen. The two bands instead of the b 1-

On the Cytochromic System of Biochemical Mutants of 20-1-53/58
Bacterium coli and Staphylococci With Disturbed Oxidation
band are theoretically interesting, as the opinion was
uttered (reference 5) that the b1-band developed of the fused
b- and c-bands. The biochemical mutants of the staphylococci
and of Bact. Paracoliin a number of cases show quite a similar
behavior. Thus the authors determined antibiotics which
selectively suppress all these mutants and which influence
the initial forms of the microorI,,anisms. Some of these anti-
biotics also suppress the growth of the cells of the acytic
cancer in mice. Defects of the cytochromic system are also
characteristicof the cancer-cells. They are different in
different tumors. In man it was a small content of cytochrome
(reference 6). In mice cytochrome b was almost completely
absent, whereas c was relatively even present in excess. In
this are to be seen analogies with the above-described mutants
of the microorganisms with disturbed respiration.
There are I figure, 2 tables, and 7 references, 1 of which
is Slavic.
Card 3/4

On the Cytochromic System of Biochemical Mutants of 20-1-53/58
Bacterium coli and Staphylocci. With Disturbed Oxidation
ASSOCIATION: New Antibiotics Research Institute, AcadenW of
Medical Sciences USSR (Institut po, izvskaniyu. novykh
antibiotikov Akademii medits--nskikli nauk S5!iH).
PRESENTED; October 30, 1957, by A. L. Kursanov, Acadei:iician
SUBMITTED: October 29, 1957
AVAILABLE: Library of Congress
Card 4/4

GAUZh;, G.. F. (DR.)
Antib -otic Anti-Mitotics in the USSR - Dr. G. F. Gauze, AcaderV of
Sciences, USSR
Report to be submitted for the First Intl Symposium of Anti-Infective and
Anti-Xitotic Chemotherapy, Geneva, Switzerland. 12-13 Sep 59-

GAUZEY G. F.
"Darwinism, Microbiology, and Cancer."
Report Submitted at the Darwin Centennial Celebration, Chicago,Ill., 24-28 Nov 59.
Academy of Medical Sciences, Moscow.

G&UZR, G.F.; WGUROVA, T.S.; POPOVA, O.L.; BRLZHIIIKOVA, M.G.; UMNSUYA, T.A.;
R6SSOL1140, 0. K.
lfutoy%vein, a now antibiotic produced by Actinomyces atroolivaceuB.
Antibiotiki 4 no.3:20-23 M.V-Jo '59. (MIRA 12:9)
1. Institut po izyskaniyu novylth antibiotikov AMN SSSR.
(ANTIBIOTICS,
mutomyoln, prod. b~ Actinomyces atroolivaceus
& pharmac 01. (Rue)
U,

GAUZIC, G.F., prof.
Darwinism and certain aspects of the investigation of cancer cell analogues
in microorganisms. Vast. AN SSSR 14 no,2:49-38 '59- 1 (NM 12:4)
1. Institut po izyakaniyA novykh antibiotikov ANN SSGR, Moskva.
(NEOPIASMS,
cancer cell analogues in microorganisms, genetic aspects (Rua))
(MICROORakNISMS
same)
(GXW=,
DUvIniss in interpretation of cancer cell analogues in micro-
organisms (Rua))