SCIENTIFIC ABSTRACT GYERGYAY, FR. - GYIMESI, J.

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• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R000617720020-6
• Release Decision: RIF
• Original Classification: S
• Document Page Count: 100
• Document Creation Date: November 2, 2016
• Sequence Number: 20
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

SZABO, St.; GYERGYAY, Fr.; LAPOHOS, Eva I.; GRIDNEVA, Alla L.
Experiments in encenhalities. 11. Behavior of the cryoagglutinins
in rabbits treated with a suspension of heterologouB brain.
Coraunicarile AR 12 no.2:255-259 F 162.
1. Academia R.P.R., Baza de cercetari stiintifice Tg. Vures si
Catedra de fiziologie 1. M. F., Tg. Nures. Comunicare prezen.-
-tata de academician D. Miskolzy.

EPERJFZSY, A. ; KISS, A.; ADAM,S.; GYERGYA , F.; YESZT, T.
Research on experimental encephalopatnies. III. Chemical
study of the cerebral lipoproteino of rabbits treated with
a heterologous brain emulsion. R4v. sci. mod. 8 no. 2/2:25-28
163.
(ENCETIIALOMYELITIS) (BRAIN) (LIPOPROTE-INS)

SZABO, St.; MODY, E.; GERGYAY. SUKELY, I.; FESZT, T.
Researd.b on experimental encephalitis. Pts. 4-5. Comunicarile AR
13 no.1:77-93 Ja 163.
1. Academia R.P.R. Baza de cercetari atiintifice Tirgu Mures ii
Catedra de fiziologie Institutul, medico-farmac%utic Tirga Mures.
Comunicare prezentata de academician D. Miekolezy.

KOVACS) A.; KEREKES, M.; FESZT, T.; Grr.RGYAY,
Research on experimental encephalopathies. Pt.11. Comtmicarile
AR 13 no-5:463-468 my 163.
1. Comunicare prezentata do academician D. Miskolezy.

EFERJESSY, Ana; FESZTp T.; GYERGYAY, F.- KISS A.; KOVACS,, Viorica
";L".- .9
Research on experimental encephalopathy. Pt.14. Comunicarile
AR 13 no.11: 1003-1007 F163.
1. Baza de cercetari. stiintifice din Tg.-Mures a Acadermiai
R.P.R.. Comunicare prezentata de academician D.Miskolemy.
f

GYLI~,, yj;-", ~ F. ; , -. ; 1, ";1 , !'~Ve 6y.
i-!~LoLic and hlstoenz~mtic af-'.ivitie.9 cf the intestinal mucosa
ir atrophic human sucklings and in underrr"IT'ished rats. Follia
histochem. cytochem. (Krakow) 3 no.2:101-114 165.

GYERGYMIL, L.
"Singularity of the Reciprocity Theorem." P. 72, Ljubljana. Vol. 22, no- 3/4, 1954,
SO: Nast 3hropean Accessions List, Vol. 3. No. 9. September 1954. Lib. of CoWese
1
~-:Z-r il '--I iii ' H !
! , t4~ I : ..,

GYERTYPIIOS, Zoltan
Career of a modest invention, Ujit lap 16 no.23:12 10
D 164.

GY&IGM~, L.
Universal diagrarn for detenaination of absorption in standard electric
band-pass. filtars, dogigned on tho basis oC i;,Li:-o paramet*ors.
0
p. 242
Vol. 23, no. 718, 1955
ELIMTROTEEHNISKI VESTNIK
Lujbjana
So: East European Accessions List (EEAL), LG. Vol. 5, no. 2, Feb. 1956

GYERU'YEK, Ludvik. dr., ing.
Stabilization and improvement of feed-back aystems. Automatika 2
no.l.*14-19 Ap 161.
1. Clan Redakciskog odbora, "Automatika".
(Servomachanisme)

GYERGYEK, Ludvik, dr., ing.
Synthesis of -linear electric circuits. Automtilm 2 no-5:264-268
N '61.
1. Clan Uredniskega odbora, "Automatika".
r- --,

GYEFC,YEK, L. ____
"The essence of information" by G.Yegla. Reviewed by L.Gyergyek.
Elektr vest 29 no.8/10:229 161.

GYJ~,'RGYEK, L.
"Knowledge and information; Gnosiological proillems of
cybernetics" by J. Zeman. Reviewed by L. Gyergyek.
Elektr vest 30 no. 10/12:320 162/163.

Gy prof. "J'3 .
mattka 5

f-r
n no i-,,e :3 1- a c o n c.
L
1 . Fa ou' ty o f 'E'l e r, t, rn-1 gr no o r Inive I v c uh sna Jana.
Y4
PHAET.T.-I

E" MMIMI'A'W
Th &&-dy* Md "Ovemblooly* Wad"" of maw
I~ds.iv.~~ C.Yftuwk. L&WO Satanyik. and Edit
, I (118 pW). Atft Physiel. Arad. &i. )lung. 1,
-tr'74(IMX EuSl6h)--Tbc adscoolytic twid syst"thi.
tic effects of d9sydrowgovornine. dihydruargotintLot.
errotawbat on bkpod pnwum of eats ism tanow.
filtallor blood-preinuft vism an observed as a fvswt of ad-
lubly iv I. of dthy-frivromod eflof alkelitille (W I vus. IM he.
'1111A tilklftw Mn 1w rwat~vd by
atioe Tlart tenths nix. to Ol ros. tit
roff kc. of body wt., 0.6 to 0.8 W4. of dAydrWOKS"Kint.
au,Uio2.2aig. of the
bkvkilid ul the hkoid-lin"Mue-litisirig effect of adirluatifte.
I Gattruk a. INTIss"a

c0
"v j L
Blood pmeters amorimTra Wilk curb&", I.- Gyrr
~,L ~stanyik. R. Uns, and 0. PatakY Will- liu&]"t-
mr
frurii.i. lek Phyfid. Amd. 56. 11mmr. 2.33-10099)),-
[n am,pinized animals, the blood preaure elevation elic
ited by carbaminoy6choline was revened by dihydrtwrg~
cornine and by tetratthylatunionium Ix-utnide CITA)
V~~Jilation of Sympathetic orijr6i w-AS not rcsix)nlibk im
Fhelall in bhx)d prewurtitinceit wasnot prevented by adrrtjjl
lig2tion or inhibited by TEA cw isuprapyInoradrenalinc.
'rhe bfuud prtmurc (" was of pamsymputhttic ofigin wincv
it wms campletly inhibited by I"Ce dowe of atropine.
Richard F. Riley

Tbe'vez;6m of biduibm *a r
A-1411=01- rim, -At All
anlw~ljl temp. of 3WIlltmi. (1).)4 Flig.AW 1, vuly-
cutancotbly, InMamd the 0 coluumptiou Aiul body trinp.
of rats atwstbctiwd with urribrAn, luminal or tmxphitw
scoWLimitte, Adrrnalectomy prevented these cbmge
At 3)' the Same amt. of I lourn-d Lwxly temp. but did no
after 0 consumption. At L74* thc body temp. ifid a4)j
ChAH9C alld 0 COMUMptiOn VMS only Slightly CIVVatr(l.
At 3)* adrenaliw lowerct! t1ke body temp. but to a k-w-r
deptv than 1. Adrenaline half the Same effret, as I on 0
consumption at 20', 24', and 30' on anitruls antiothetized
with urethan. Richard F. Riley
AW-

'', .1.
GYMM, L.; SZTANYIK, L.; LANG, N.; FATAKY, G.
Blood pressure experiments with carbachol, Acts. ph7siol. hung.
2 no.1:33-40 1951. (Cin 20-.9)
1. Of the Pharmacological Institute of Budapest University.

GarWloulc blockiu# activity of tropotits. L Cyrroork
md L. Sztilnyik (Univ. IludApest. AM7lwj,;W.'----,
I,ad. Sev 11stiog. 1, 41-7i(MO.-Alropineand himialnl," .11,
1-hhAtIl lite likolillICTITectsof the b, .1
prviwite tise irmilting ftmn jAAnChUiC I)CIVC '4111111ILMUll,
... id I he %:~,utruct ion o(rats nic (it at ing inembrittir (win -t imit.
latiml ,( the flef~e The (I'llwill cf-
'hirall-I 11-1 wt 111C W-f ... v - "
wu*.t times xliwjx~t thunolj~,phjr
to I times stronger tit the rxpls. %)it the nirtilating
p'icuibrule. Afroplitir suirthyll brumWe paritlys"I the uipe-
rior ccrvkvl ganglion to an citcrit sitnilAr tit lusituttrorlifte;
Irtrarthylammonium brunikle was klm efferlive Illkil the
quaternary trupebw W. 11-41 F. Ittlell

11 H
GuStim-Makift stedfas of troplins "d troplWam.
(I.Yerlurk (VnIv.
Tropine (1) injerfM ;it 1,11 mg. doses praducril is I-try"j-
"'1191kin blocking effect In the cut for 4-0 min., while the
effect of 5-6 ing. Usted (bir 12-13 min. The effect was
-tic-
rac Ally the rume as with atropine, but of shorter dura-
P
Iion. The quaternisation of I sliXtilly IncmawA the effect;
-fer, of I flare 4 M.Ch greater an fix lioll-I'lork illit r1tert
after q1lart"llitallon. IL L Chil"s

The IICVAU of Wallantlaw 00 metabolism. L. Gycroirk
and Oy. patally (Univ. nudArst). Afla
3ci. Hung. 2. 179-"19SIXin Germun).-Guinca phii
were siven a 0.2% histantine (1) suln. hy aerosol and the
tittle 111ramired FEW apFcarance of drilltra. After contr0i
V.erv obtained. the Ian InAll, were Ely it I Ing.11vit. thyroxine
on the Ith And Sib days srus not sitnificaully changed. 0
consumption was increaSed by 1 (8 tux.ji(A) a.) alone. 0
consuniptioct lncrra~.l Ivy 71% when 11 (till-101) 11411) X.)
was given fur 2 to 4 days. With 1 (4 nis./IM it.) alone
the inctruer, was 107v; after 11 the int-fraw WAS ;17%. 0
uptakc %Vaq 111wer Willi adfru.skVtoulls"I IhAll with floculAl
411filU11% After L PYIPM11241nillf! (111) lines not inhibit the
incteawd inetAbolic action of I in rats. Treatment with 11
had no influence on the I-hv4ucrI bronchmixtsin. In
guinea pigs treateti with III a rise in stirtaiv,dimn wa~ pre-
vcotcd even nhcn nuiny-fuld lethal dcw%of I were sh-rit.
11- 1 Chiluk
11 VA

GYX U*X, L.
-, .,-,
Studies on the cholinergic blocking substances. 1. Sites of action
of compounds of the atropine group. Acta physiol. hung. 2 no.3-b:511-
517 1951. (GIMI 22:1)
1. Of the Institute of Pharmacology of Budapest University.

FgnyL-,, G.
AU 4drannUn serum k as vor(mikw b4tasmak bafo3,v=olas& ove.
p&UauB bordtokkal,, /TwMbltion of tho offoct or adrazolln
on 891,114.1 Potosolun an7l blood onlar lovole by QWatholytU
acwltx7 KiverlatoB ornstwd. 30 19.551 P. 203-9o
L Plinmacoutic Instltuto,, Budapest I-Wical Tinivw-jity,
CLML 202 10, ()at,. 51

FMTE, G.; GYEqMIIK, L.; S"UTAITYIK, L.;
Invoetigation on the relation of serum potassium and cfLrbo-
hydrate metabolism. Kiserlaten Orvostud. 3 no. 5:338-342 1951.
(CIRL 21:3)
1. Technical Associate for Coak. 2. Institute of Pharmnceut-ics,
Budapest Medical University,
Tdlli:'~i

A vqptativ ducokra hato, gy azeTekrolo Lffru,413 affecting the
vegetative nervoun gangliow-T Orv,, hetil.,, Budap, 92s25
24 ad= 51 P, W843,
3.0 Doctor, 20 PhwrAmtical Institut# (Director-Prot. Dro
B*U leaskuts)p Budaperit Medical UrdvorsiVo
OLML Vol, 209 No. 10 oat 1951

q
Synthesis of compounds-eif-i
Adrenaline-blocUing action. Klirolv Njk~r. N
7414,~l IWII .19,52) Jnn
I
I
E
.
.
With the object of finding coniptis. with Adrenalie. ' ekinIr
effectii, varions ArOClf,CIIINRCITICIT3%.IlX (LILK) ii, "I
RN(CITIC11,011), tvm: voltv"Ecit to Itell"11
alcoholates atid then tmited with aralkyl halities to I:iN -
ArOCI I:iCll:N*RClI:CI 1,011, These %yere cutiverted ivith
SOCII or S013r.. to the corrLipoviding Cl or Br dcrivs. Tb?.
folluiviii.- I ivere prepil. (R, Ar, X, to , Ail rt~nafin e-bluckin U
CiTCCt (t~t! Vfflk'13 Of ffib'U'llamille - Me, 141CIE1,
0.3; VILCHt. PhCH.., Cl, 120', OZ: PhCH., PhClts,
Br, %.". 1.5; 1-naplithylinethyl, PhCH... CI, IeW, 1.15
;
,
IIhCH:, 1-implithylinethyl, C1, W.5* (d%compn.), 1.0; Mi.,
(A), C1, W'O' 0.2; 141CII., A,
C1, 1.0i 111tCIT., A, m, "'o. Thc I ocTu
feattily ~ol. ill 1110. Thc 1.1-z Lot.-IINI, i-nuwA Lowl-Acti!
~WUI'110~,VIIIJ)AliiC JI:Lf;IIYSiI With a do-;~ of 3-1
iLlkLLtIVI'-VId LJ)-(UC 1114-C Ott

Chemical Abst.
Vol. 48 No- 4
Feb. 25, 1954
Organic Chemistry
Attempts to find fiLw compounds with curat clilic effectx.
111. Quaternary derivativen of dicarlint7fir. tLqgJapg. "g
so Kfirolv I'llidor all([ 4-isAA G
XeVA -k
'.TeU'rrAP1I!. 2, 369-7-1 1952),in
ngTish); cf. C.A. 46, 7517f.-Seveml eptatertiacy i1crivs.
of iuccinyt- and phthaloyltrophic wcre ftyllthe'ired with tile
object of establishing tile changes in 101annacol. rflects al
the quatetpization of bis-quaternary comptiq. by aralkyl
compds. which, as; a rule, yield derivs. xvith ganglion-block-
Ing Wicts. Succinyl-anfi-tropine (1) b,,." 140-50", was
pd in 6 g. yield 820% by pouring ~.5 tul. (0.025 mote)
Fcrtff,60M, n 7.1 g. (0.04 rnole) tropinc-110. kLcpiag the
reaction mixt, 3 tits, at 115-20' with air and intlimurc ex-
cluded, moiAcning with water when Vs fortnatim ceas",
adding NH, to pH 8.6, slinking 8 times with eight 25 ml.-
portions of CHC1l. decolorizing with C. removing the solvent.
and distg. undcr reduced pressure- Phtfiallayl-onti-tropine
(11). m. 65-7'. 13 obtnincd by ralsterification qf tropine
with o-Coffi(Milt), in the prownce of Na. The follosrit,g
MICH NMc.R'X
R
1.2R'X (R - -ClilCHr-) and II.2R'X (R - 4-CJ14) werle
prend 'P~'~ a d ,,,7,d. (no. given); (11), Mel (N-2.97)-,'
(1c). m_BrC S. ff.CHBr
~Af C.W,C N_M);
(Ila). Afer (N-305); (11b), PbCK,13r (N-3W).
310* (clecompa.)l obtained by adding Met to I in
abs. MeICO, allowing to stand for a day. filteting, washing
'the ppt. with AletCO to remove unfeacted substance, and
rccrystir. frorn Mt:OI1-Ft,0- 1b. sit. 200-2' (demmpti.).,
Lrc!~ In Nfe.-CO with jFt.pr

compti.), ~epd. b aciding m
Id -BrCsI1jCItsBr to I in WX01
allowing to stan 3 days, filtering; and rmryr*g. from
MeOll-Ot.0. Ila, m. 298--300* (decon' U.), prep(l. Ly
quaternizing 11 in MeICO with Me, .9 mcr)-!;tl;. from
water. nb, m. 218* (cleicompn.), obtained by refluxing
Il 3 hrs. In Me,CO with PhCll,Br, filtering, %Nnshing the,
salt with MqCOcmd recrystg. from McOH-rst,O. Pharma-
col. tests revealed that the cutam effcct Is prt,-domin-mit in
the bis-quaternary detivs. Cotnpd. N-307 proved hi [tog
vzsts to be 2.5 times and* N-300 5.0-timm mg rtit-ir as d-

GYFMGK, L.
, I
The role of tj2v halogen groups in the pharmacological ffects of
dibenzyl.b-chlorethylamin* (dibenamine) and dibensyl4bromethylamine.
Acta physiol. hung- 3 no.1:165-173 1952. (CLML 24:3)
1. Of the Research Institute of the Pharmaceutical Industry, Budap"t.

GYERMW. L.;N&WR, K.;KOVATSITS, H.
- ------------
New adrenaline-blocking compounds. Acts, physiol. hung. 3 no.1;175-182
1952. (GIAL 24:3)
1. Of the Institute of Pharmacology of Budapest University.

kNADOR, K.
Studies on cholinergic blocking substances. II. Correlations between
structure and affect in antimuscarine. ganglion blocking and curare-
like actions of mono- and bis-quaternary ammonium compounds. Acta
physiol. hung. 3 no.1:183-193 1952. (GLML 24:3)
1. Of the Institute of Pharmacology of Budapest University.

GYKRMM, L.;CSA , Z.
.Oqay-%~~
A method for the bioligical determination of ACTH. Acta physiol. hang.
3 no.3-4:563-570 1932. (CIAL 24:5) -
1. Of the Research Institute of the Pharmaceutical Industry, Budapest.

GY-bRNRK, L.:SZTA.NYIK, L.
The effect of histamine on the adrenal gland. Kis*rletes arvostud.
4 no. 4:241-247 Aug 1952. (01*L 23:5)
1. Pharmaceutics Institute. Budapest Medical University.

GURMA, L.
Method of testing of local anesthetics. Kiaerleten orvostud.
4 no. 6:401-W5 Doe 1952. (GLML 24:1)
1. Pharmaceutical Industry Research Institute.

t -.I IIFII OL111 F31rIM? i
33. New vompoillid, willt lilt-III ljlljw~1114 tilt Ikvli%IIv'-
1). Loillivi-I mitt Gy,-Villk.l.' I.Jtarclplj
K611iid PoI11141al - Vol. ~iS, 1952~ No. 10.
312, vol. 60, 1931. Nif. 5, j;j).
It is klioNvil lil;%ildy fruill l1w iav-~,kflj,'a~kt I Is
calrivd OUI Is\. L;ifilk'll 111A thV
;it Ili Im"Illicylit- lillifides. LuIllithilvs. Ov. (tilt! xylocidilt,
I
In orth'V 14) CAUdIlkli Ow It'hil-imis liellwot Olt.
chollical sirlwhirt, 'kill[ thi. lov;d ItIml-AbcUl! ;tai 4tv.

compr'linds wo-v I)ropil-ell.
gol'o ~%Ifilidos allit loilli(li&N llropar~,d ' froilt the
Olloluict-I)i (tVvivaLives n1loty lovill,
11wicAlIL-tic !it fivily, 111111, -wvvot vollipotilid-,
silk-tris.., Nlovoellillu ill I Lis rt7s1wrl. ~ Qw-ir. (o."it-ity ii
)ow Init. s Lrull.-, Nwal irrillitill", prohibit.
LviV 1) Mc I it' a IWjV. Tltk-W iI'fjj-.tjjjj!.-
I I a DiloA it's
hv (limilti"I"'d Mid ~,OlltilkllletillAy (lilt Ilitilol"wal
ni.tivity Ill lilt- voillpollild illi'vomcd I)y - l1w illtro.
thictitill of a wcollil frev. nrolliatic illillito I'mull.
I lowt!Ver, tho Illus obtained &-livikOws [if-v highly
tij,Jr. This loxivily van lie dililillisholf Ity I It-!
acylation (avotykilion or sitccliqlatiol)) (if I ltl~

j

lt~" I lit,
Sv.
A
c" A.
second milillo group bill. Olvir aclivi(v i:i roducoil
cloylaillino allilide lircila~vIi has it "mittor"
ionic structue aml Lliviviorv it is milcr soltiMp.
It proved to lie a more- poleuL loeal Won
Im,
Novoenijlt~ ill Spit" ot it', (mork, previ 11,
iouiied) carlioxyl gcoup, Seveml quaternary dvri~
valives (it (lie compollmh mentioned above Yt'vri~
prepare(I and isivestigated ill rvilivi-t it) thelt
cological Value. 'file local zalarsilletic artivitY of tile.
alkyl (Ittoterlotry compotit'As is low, tile m-livity (if
the allylic quaternary compomok wmi foumt It) be
of tilt- smile ordvr at, thal it( tile IcTliary -mills. Oiw
it) their low Solubility ill water tile biological "ItAivit).
of tile henzylic quaternary coutl4iounds vas not
invo-tigated. In respect to the, vE(vA of 1.1.1c otackar
sill) Stif Uen (S oil tile local awke-Akivitic potellcy of
be dr; wn that
them, Compounds tilt, A~tpiAkisiou ~cltu I
lissullie
not only tile d by I.Wgreu
and Collaborator,., to 'he solely resliousible for Ow
pharmicolo!Ac activily - but tilt! elt-Hron affinity
of tile substituents k also of decisive impurtanec,

Vfdunttion of the Alrenocorticotrooic Hornones."
60 SUDDlement to V. 4, 1951, TBuirinest)
P. (Acta FhX~jk!~~op I
s0: Vol. 3, No 6 Librtiry of Conf~niss, Jun 51,
Uncl.

GYFMMK, L.;NADOR, K.
Studies on cholinergic blocking substances. III. Neurowuscular
blocking tropeinea. Acta pbysiol. hung. If no.1-2t159-174 1953.
(GLKL 25:1)
1. Of the Institute of Pharmacology of Budapest University and of
the Pharmacb-Induatrial Research Institute, Budapest.

Thc phuma~ctpgy at tr tsmMei t ndiWe d h 4
ft -PAq
phimmaylandne (111) ca VtP blood Frcirmaz: CP
.CRO was stucfW~ PyAumaitie, mial-An.
=d trimeton 6-vialib. the abilitY of 1, 11, =d MI to milsfi-
thebloodpMsum, The =3a ;Lvtkm 01:1,11, and Mccci;'
of a,, dlro~t va;mular coramitan whJ6 Is "t oltertd.. b,4'
adrvu.-r& blockIng r4imir, A -.9.40&lPtcry c&ct is *19~'
d=01strable. Harold S. YJAIOQ~

"M11 ilil"I'V IM
RM., Lb

.6hollnertic; blocking substances. IV. Correlation be
'twsen 'stmcture and effect of quitemary detivilairm of
banioyttropine slid benzoyl-ip-troplrie compounds, L.
(Pharvrc.-lwl.jRe-;carch Init., 1111dill)(.0.
Sri. 4, xa-40(lvx;Yit1
C.A. 47, 121iMs.-The coridation-i iv~v! itudicd tx-:,
twt-n stnicture and OTLet of troiwines luving local unm-
thetic and Cholinergic blocking activity by n3ing the Me]
'
Chemical- Abst. T V). atid MCH~Ri(V)
(1). EtBr(II), PrBr(III). DUU4(
Vol. 48 'No. 3" qll3tCr"ty (11VTM. Of b--llmvl-
P-tropine-11Cl(VIl)- anti the jlLwerimr~ keramy](VIII)
Feb. 10, 1954- diriv. of VII. VI and it~lc quatermiry dcriv-.~, have gmater
Biological Chimistry alltinitlicidneactivity (flan VII acid it'i di.rivs. I'll'arldill
derim of V1 >.IV. V. wid VI it, v4kraquitImIL11~6C Necking
agents, Whereas tilt derim of VIIA10%vul little diftleacc
ill actioji. *All tonipch. Mioived siriflar block-hig action on
hatit sympathetic atid parasympat Ili; tie gattKlLi.- I iknd V
derim of VI shoti,ed lvjit cold 1V
1eriy'-('f VI acid V11
1:
nhllw'~Il greateit cllrali'lv elf'ct' ttiv'. of VI all't
VII are inferior to VI and VII a, lo,:al xi-thiti.:,; ho,-.estzi,
11-and V derivi. of V1 and IV, V. awl Vil are
%imilar int activity Ici VI and VIL Dcii~ . of Vil iitcrva~v
Ami'llictic activitv ill Jilv~l pCol"'llioll 10 i!;,*;,,%,, ill ';-t: -I
tile jilVy
A
"pub
14
J
ml I Will 't "T, i.
H

E ibs' y at
ftatln& 6, tance3. V, Phurnacolog
I Ite"
trolges acting on Tegetefive gan-fiti.
0 na",
R--
Wild ~;,NfiWor Mcd. Unlv,. B
A
c4d.* t, 7TMM43)1
g IM); cf.

U N,(;

holytic, curariform, and local unes
ing ciTcets, va~i
=
cs of wany new quaternary tropelues
thetic activities
',were studied.
acetate of S-beuz,
.5ltroplnlun% bromide,acetate of
iodide (I)
bromfd~, and t1te* nitu, yj t)rQmI ettlyl O
M
l
~
;
.
,
bromide, (Uniethyleazlianinte i1
r
"le, J
jr
bromide, bonxyl bro, mpl
n1da 4 - ~rofnI
I 1W.IrYl brwill(h
~14,-

of 8-inethyltropinitun iodide (11). dimethy1carbamate of 8-
f .
Mao-
hentyl bromide,
-
r-broMe,fien-1 bromide, ::y1
!
l
J
lbfumide
'
t-metl
Ib

In.rs-8-methyltronixt-
benzy1tropinitirl bronlide, lj~nxoate o
r
h iv
.
elljyj
P-MV
We. ,
~-nitrobun-zyl broi
i
n
de,
1- b
P-Jncth-
bcn
opHum iodide, Un-
imn iodide, hcrizoate of cii-S-met
ylL
-
t
i
i
b
id
l
f
i
b zv
Y
rorli( c, I-naplithylinctilyl c1.
!,,1ld!-.
l 'b
-Pht1*7111'eth
i&
~
t-v
s-
u ni
rom
a
~zu
e o
c
zryltc of Ira ns4Aenzy
trop
e,
-J
id
f S
i
b
L
b
l roru
y
_ P-P!-1-1131t
f
np-1 . bromide
diPhen)-lmeth
l
-enzoate o
ram
,rorro
)-
nium
euzy
8-benzyluop
e,
4t- y
bro-
nice, P)CUiAby-1 i
-b
and
tropiniurn bromide, benzoate of 8-(P-phei3~fbenzyl)tropm-. romoNnroyl
p
""hyl bromide quafe-,narT
de
h
f
r
i'ium. bromide (111), p-aminobenzoate of ~,benzvltroplnium
brovaide, P-,m.nobcnzoate of 8-(p-chTr,1obcnzyl)tmpiaium r
o
the dt pjajdej~jte a
. f tMPlri, The P-phanylbeti-
.Zyl apd. haloben.-yi-iiiinternarict tjore t1le most; ai~ti
t

-brondde, p-aminobenzoate of 8-(I-Aaphtbyluiethy-l)tro- ve
ganglion-
iclaing agents, IV is!Z-0 times strong&
'
It
pinium chloride, P-nitrobenzoate of);~-(p-chlorobenzyl)tro- ' tetraethylammonitan chlo:,i4je.
Cozapols. I and 11 have
'
pinium bromide. P-chlorobenzoat----of B-benzyltropinium
lim rauscmrinic action. COMPI.Misav=yPotell
t Sympathetic
ganglioa sti
l
piniurn iodide, phen.
bromide, phenylacetate of 8-methyl
l mu
aat.,
Harold S. Rkilaj
ot:
ylacetate. of 84)enzyltrop1niurn bromide, phemylacetante
~.8-(p-brcmobcnzy1)tropinium. bromide, phenylacetate of 8-
(p-phcn),Ibe.-iz~y:i)trapitiittnx bromide, diphonylacetate of 8-
methyltropliduri itAide, diphenyluetate of 8-benzyltro-:
acetate of 8 -lbenzyl)
pinirm broadcla, diphenyl, -(p-phenj
.tropinium bromide, tropatc of &-niethyltropinium bromide,
i tropatc, of 8-beazy1trophilum bromide, di-tropate of 8-(p-
a--yl)tropinimu bromide, 1-tropite of -3(p-brorno-
I bromobe
t -plienethyl ropiuium
~1) ropinlum bromide, ropate of 8

-1- ffl.. u, al �~j-zquw g I It I Ij, tail -.1,ILHMM
ip! M

--
Pharmacology of T-52 tris- (dimethylaminoethyl)-twaine, an oraI14 effective
ganglion blocking agent. Orv. hetil. 94 no.14:381-382 5 #pr 1953.
(CLML 24:4)
1, Doctor. 2. Pharmaceutical Industry Research Institute.

A;
0,
synthesis and blologleal acti-Vity Of dipbenyl and lndxno
Horivativeg. LAszl6 Vaillm, T. Horvath, T. 'Mrgrldi,
and imh List. Phmriu~ Ind,t Budapcit).
rryR e s,.c
-19(1054Xin German)
A cia . Sci Hieng. 5, 111
(Einglishn summary); cf. C.A. 45, 67=-S~nthtnis of in-
datte and diplienyl d"Ivv. with side chains chai-acteristic,
:of corticosteroid hormones is rerorted. only 4-AcOC.11,
CjT4CII2COCHiOAc-4 (1) showed weak cortisone-like tic-
tivity. 4-MeOCJ14C4H4A.c-4 (45.2 g.) In 66 mi. morpholine
refluxed with It g. S giv~m W g.
ticair "id morpholidd (b), in. 14.1' (from EtOlf). Re-
fluxing 50 Z. la, 67.5 ml. 500/0 NaOR, nod 335 mi. EtOR
ve3 30 g. 4-%feOCJI4CsfI,C1TiC%H-I (H), in. 184-5'
:~froit,'At:011). Ittuxing3Dg.llin2OOml.AL011withco
43% JIBr gives 24 g. 4-HOC.H,Cs1f,C11,COj1-4 (111),
(fiont Ai:OH). - Heatinj 23.2 g. M with 23.2
dry LNTaOAc and 46 rut. AcjO gives 14 g. 4-.AcOCjIAC4IF1_
Cl-ItC0,H-4 (W), m. ISS6-7' (from EtOffy, PeAuxing M
g. IV with 100 ml. C,11. and 100 ml. SOCr, gives 20
~' 4-
ACOC;H,Ctfl4CHiCOCI-I(V),COTOrICS:.CryStal3,fli.
V (8.67 g.) in 150 ml. abs. C&Hf treated with 16 g. Cfll%,2 lit
SW irif. Et-O gives 8.12 g.
kelotis (VI), light yellow crysts., in. 115-16' (front C&114).
VI (2.94 g.) in 40 ml. dioxane treated with 29A nil. 2N.
HyS04 gives 1.2 g. 4-AcOCjHCaH4CH-COCIItOI-f-4 (V;1),.
colorless needles. in. 13C-7* (from ate.). VI (6.83 g.)
heated with 60 in]. AcOll lives 4Z3 g. 1. snow-white Inves,
Va. 117-18* (frNra EtOU). Rtfi"xitig 2,84 il, V11 with 15
ml. At%O gives 2.0 g. 1. Treatment of 121 g. of H%CC11-
(VIDD with 240 1. J'Cl, folinived by terno-ral
n . of 12 1 g, anhy-j. MCI;, ii, 180) Int. Ph N Ot
K Vm 6( '"0 -g. 34 Mr.14 n im f- I -'r, a rti ( %:Y I i~7 C,;ij !I i ota I I L4 f,-L, (110,
in M 5' The kcto-acid is redtlectl (c[. Fic!t~ C.,I. -13,
_~ ilit .11 W'ide (XI),
13WD - indaue-l-car6m;ic acid W; 4f~d 5
yellow oil, bo I 13~40*; the amfdt (' XII), iii. IV~V (from
14,0). Tan soin.of-3.5g. CY1,11iltz 1350. Iit.-D hzUtti
6 g., ]a giving, 5~2 g. idar;yl-r-dtlisapne~'kyl ko.'e-sjr (XIXI),
dari'~-ellnw oif. Mil (7 g.) in 70 iul. dionvie trmted w,.th
15 ML 10% H.So. gives M g,
(XIV), oil, b~., !),J-f02*. XTV rplucts coSI _-~dlug 'd
B-L
Tollens solus. Heating 7 g. XM lit 25 ral.AeOll gives I-
(XV), oil, 4-44 IIS-2 I.1,
bw
xl~ (3,2 g.) 111 6 till. 1);jTfd1tL tn-,,t-zd with 3-7 tnl. Ar,01
-2 athip W `0 nil.:
gives XV, be ct 117 M*, lie, , 4.4 of 1% -lit U
CJI# with 5-3 g. Pb(OA64 gives, vi renitwal of lib-3,1ts as i
Pb-oza?afe, 2.7 g. of
1XVI), 61, fi~j-eqj 1071-10" bt.; TVI'(1.25 1'.)
in I'-) int.. abs. hfeOH tmated wiLb 6 nil. I N Me.0ML
followed by 0.3 tril. ArOH gives 0.%~7 g. of ctud- I-Ijydtai~y-
1-(w-hydracyacetyl)irdane (XVII), thick drup. Heating
0.52 F. XVII and 0.71 g. PhNCO In ~~ nil. C.Ill uMer an lut.Tt
-
9 Mi AfspAcn3lurelhan, yello-s- cx)rstaLq,
as gives 0.7 X. of Lhe X
in. 103-4" (front ligrair,!). Ifital-f 0. H:Vjtle

G_.
H,.wgary/Grgan1c Chemistry Synthetic Organic Chemistry, E-2
Abst Journal: Referat Zhur - Khimiya,, No 19., 1956, 614-97
Author: Beke, D., Lempert, K.,,Gyermek, L.
Institution: None
Title: New Local Anesthetic Agents
Original
Periodical: Neue Lokalanaesthetisch wirksame Verbindungen., Acta chim. Acad.
sci., hung., 1954, 5, No 1-2, 143-149; Germanj Russian and English
resumes
Abstract: There have been prepared a number of N-diethylglycylanilides
ArNHCOCH2N(C2H ) (GA) containing various halogen and alkyl sub-
stituents in t~;2 aromatic nucleus and the lccal anesthetic proper-
ties of the-hydrochlorides anA acid succinates (AS) of these com-
pounds have been investigated, On treatment of ArNH201CH COC1
there are obtained ArNHCOCH2Cl (CA) with a yiej# of 7~-~; which
give with HN(C2H5)p the GA with a yield of 60-76 ,%. The following
CA and GA have been prepared (listed are: Ar, MP 0 C, of CA, and
Card 1/3

Hungary/Organic Chemistry - Synthetic Organic Chemistry, E-.2
Abst Journal: Referat Zhur - Khimiya, No 19, 1956, 6-',49r,
Abstract: MP 0 C of hydrochloride of GA): o-chl(.).ruphPnyl, 74-75, 108-111;
m-chlorophenyl, 100-101, 219-221; p-chlo-rophemyl. 168~ 178-1791
2)4-diehlorophenyl, 117-118, 172-173; 2,5-iichlcrophenyl, 115-114,
172-173; 2,6J*chlorophenyl, 172-173, 168-169, AS, MR -130-1320;
3,5-dichloropbenyl, 141-142, 2o6-207; 2,4,6-txJ.,.-hIor,)pheny1, 181,
218-220; p-bromophenyl, 176-177, 161-168; 2-.br~n-6-chlorophenyl,
167-17o, 175-181; 2.5-cUbromophenyl, 136-138, 188-190; 2,6-
dibronWhenyl, 170, 195, AS, 132-134; 2.4,6-tribrmophenyl, 217(-218,
211-21'3; 4-chlor-o-tolyi., 128-129: 120-121; 4,6-dichlor-o-tolyl,
177-178, 177.5, AS 102-103; 4-bram-o-tolyl, 132-134, 152-154; 4,.6-
dibrom-o-tolyl, 196-197, 135-137; AS 100-1,02; 2.6--d:Lchlor*tolyl
167-169, 193-195; 2-brom-p-tolyl, 118-119, 146...,47; 2,6-dii5rom-p-
tolyl, 188-19oY 18.87190, AS 138-14o; phenyl, 134-135, 108-1090
0-tolyl, 112j 1.1.9-120;- p-tolyl, 163-164, -14''7-11,8; o--eth'YlPhe'iYl,
102-104., 138-14cr;Cr-naphthyl, 159-4, 162-1633 2-methylnaphthyl-l,,
167-168, 210-211; about V2 of syntffbsized GA have local anesthetic
properties approximatirig those of novocain. Substituouts in ortho.-
and ortho'-positions are not indi8pensible f-r h.I.gh anest
-hetic ac-
tivity, thus GA (Ar = 3,5-dichl$rophenyl) :~3 as actf~ve as the
Card 2/3

. Hungary/Organic Chemistry - Synthetic Organic Chemiatt7, E-2
Abst Jo,,umal: Referat Zhur - Khimiya, No 19, 1956, 614,07
Abstract: 2,6-isomer and exceeds that of novocain ', lwhfie GA (Ar Z 4-chlor-o-
tolyl) is 1.4 times as active as novocain.
Card 3/3

H 1) N
New IoCat P. Mx, W, L(,,,pcft, all
(.4c.a rh.~m. huiq, 195-1, 5, 151-M ; cf.
sa lLh titu tl~d JiL thyj iyuylam il,
Alm-.5 that, %vithill thi, 1.1-~ of vmlj~4"Irtht, the intit'dacti-Ill iat;~
tht, mol. of o. furtlicr mbtitacrit fl.,31ogen, 111hyl. Nol, Nile ur
;icyLimide gil-ii,p) into till, frl,,~ tjjjljo pbsitic.1, (1.4itil r,~!jpvcl to t1w,
sroul)) imrvoics flw anxsthetic: mfiviy i"en,
the Ociarclix affinity vI the now iubititzient. Stcrif
ar important. If the sainn si<itu.11113 all!
glVLYlAnijijC, thtir elf!ct on the biological activity (if the !;irodiict
cicliunck on t1wir clectrou T140 pr~ W civicritit'd era scries
'1 0,0111 .
of 2 _- d-4iclAorr, or -dlbronip.-4 " r, Lcmilidei mith an Nl_
group. The dill alkqer.;A tilli ne ii tfuAted %vith
an(I zlie jjzolu-~t -,;i!,,,vd with NHL-. u Ilim. til-
dihalogea'-, V~114rh 13 P.M"
acyl,xv-d to th'i
Quatemaq- deriv. of the lat~mimrd are prepared. 1.,)ru 11 su anm
~21%.P- Of all LIJIIIPOUMdS OlrC qiVLfl. if. WREN'.

Cholitiergic-blocking substances.. Vt. Phanuacology o
MarueMonium;,and penpin.2-type ganglionic-blocking
ro"e*'
compogdas. j..,C !,Mek- (Phitrina6a-Industrial Research'
T
da r qYSIO . AMC -let. 111ifig.
I Inst.. at dFa
c(. C.A. 4 )7f.-.,. tie Sympathetic
in =Mshl- c(. C.
ganglionic blocking actions, toxicity, absorption front the ,
of rach of the
gastro-Intestinal tmct, and mydriatic action _
following comptis. were detd. and comparrd: Lfl-hi,(tri-
methylamrnuniutn)htxanedil)romide, 1,64jh(dimethylollyl-
arnmonlun0hexane dibromide, 1.6-bii(dinictitylliciizyi;iijt-
inntilutu)hexane dibrontide, bis(climctltyleth~,litidinonium-
,11thyl)methylamine dibromide, bis(dimethylethyLtinnio-I
nitimethyl)meth)-lamine(licliloride.bi-4trimethylammaniutit- -
ethyl)arnine dichloride hydrochloride, bis(dimethylarnitio
Zliyo
'ethyl)mnine Whydrochloride, and tris(dinact hylami
uqilne triltydroctiloride. IH!, 1~1'
S. Ellis

I
tMTE, Gyorgy,; GYERMEK, Laszlo.
Method of determination of dextran In the tissues. Kiserletes
orvostud. 7 no-1:64-87 Jan 55,
1. Gyogyszeripari Kutato Intezet.
OUTRAN, determination
in tissues)

SZFMNI, Adam, dr.,; KOMAROMY, Jozeef, dr.,; ERDSLYI, Gabor,dr.,;
ETMP~PKszlo. dr.
Iffect of thiocyanogen and of other hypotensive agents on hepatic
amino acid oxidase. 14W. velorv. arch. 8 no.2-.55-57 Apr 55.
1. A Budapestl Orvostudomanyi Pgyetem III. oz. Belklinikajanak
(igazgato: Gomori Pal dr. eg3retmi tan r) es a Gyoj7ozeripari
Kutato-Intezet (igazgato: Gerece Arpad &r. egyetemi tanar)
koalemenye.
(LIVER, metabolism,
amino acid oxidase, off. of thyroidectomy. thiouracil.
thiocyanogen hypotensive agents)
(DARY11ROGNMASES,
amino acid oxidase in liver, off. of thyroidectomy.
thiouracil, thiocyanogen & hypotensive agents)
(THYROD GIAND, effect of exicision,
on liver amino acid oxidase)
(THIOURACIL, effects,
on liver amino acid oxidase)
(THIOCYANATES, effects,
on liver amino acid oxidase)
4

ChOU'leirgic bloc.Xinz. rmintnirces. VII. Correlations, ii,t.
'i tween and cholinevwrase-bItiCting
1, c ritfk- lllharvyaro~wl. Re-icArch 1!,it,
-i.
(,'at, 40, 'Mollo qnd hii Ip ifptlial.)
..'nimpdr. will% trorjarl,! itrovtvrrc~ h-az tistid li~,
effect. on pseti(lit and trite "hijul mi. inNst intil
Tnuc