SCIENTIFIC ABSTRACT GAVRILOV, N.I. - GAVRILOV, N.I.
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CIA-RDP86-00513R000514510002-3
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S
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100
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December 31, 1967
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SCIENTIFIC ABSTRACT
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GAVRILOV, N. I.
"The role of sanitary-hygienic measures in reducing the morbidity
of workors and employees of the Podoi!sk Mechanical Plant."
Report submitted at the 13th All-UnIon Congress of Ilyglenists,
Epidemiologists and Infectionists, 1959
GAVRILWOV
Keeping records of morbidity with temporary disability at
the 14.1.Kalinin Machinery Plant In Podol'sk. Zdrav.Roa.
Feder. 3 no.6:8-11 Je 159. (HIM 12:6)
(PODOLISK--INDUSTRIAL HYGIMM)
CAUIWF, I.I.
-------
third R -- of the Onsoll on Fbdloal and hophylactle Assistance.
Zdmv.lb~.Fodor. 4 mo.IA244 Ja 160,, (NIRA 13t5)
(PMIG Em )
GATRU"I Noll
lWintration of mistakes In medical diagnosis and disability
evaluation e. medical and propbylaetic astabliebmuts. Traah.
delo ne.2.-181-183 P 160. (NMA 136)
1, Nediko-eaultarmaya, ebast' Pbdolletago mekhanichaskogo savoda,
IMSUI NJ, aLlialm,
(MOICAL RIONDS)
Utilisation-of latent facto" in ambulatory polyclinic service for
the po~ulatian. Smmed. 2,11. no.8tl24-128 Ag 160, - (KM 3380)
1. Machallnik otdela meditsinskogo abolushivaniya gorodskogo mseleniya
i rabochikh promyshlennykh predpriyat1y Ministeretva x1ravookhraneniya
F93PBR.
(PUBLIC HELLTH)
GAVRILOV, N.I.p kandeekonomenauk
In friendly Guinea* Friroda 50 noo7t73--80 J1 160. (MM 24:6)
1. Institut Afriki AN WSR (Mokwa).
(Guinea-Deseription and travel)
GAVRILOV N I
1ZA - ~V, 1,6116
1
In the Gollegium of the Ministry of Public Health of the RS*F$S.Re
Zdrav. Roe. Feder. 5 no. 2:43-44 F 161. (MIRA 14:2)
. (JENINGRAD-PUBLIC HEALTH)
GAIMIM N.I. '
!Organization and method of studying disease incidence among
industrial worke~sm by- V,A,Mozgliak6va. Reviewed by N I.Gatrilov.
Zdrav. 116s. Feder. 5 no 6-S49-41 Je 161. iMIRA 14:6)
, (INDUSTRIAL iYGM M-) (DlSEASES-REPORTIM)
(MOZGLIAKOVA, V.A.)
Sle'prblam,* in t&6-j", ot -local *o of the publIc health
stsis ZOMT. Rbs. 6ii~. 5 -no. 7:3-8 -, J1 161. (MIRA 34:7)
(PUBLIC HEALTH)
GAVRILM-, N,
NProbilem of therapy and prophyUxiv An the vinage.0 7#&av, Roo
Feder. 5 no .11&44-1+5 H #61. (KEU 34:20)
?KAT IN PROVINCL-PUBLIC HULTHO RMIAL)
GAVRILCVf N.I.
- "For the worker's health." Reviewed by 11J.Gavrilov. Zdrav. Ros.
Feder. 5 no.io:36-37 0 161. 1 (141RA 140.0)
(INDUSTRIAL HYGIENE)
GAVRILOV N I 1cand.med.naWc (MoAva)
Measures for the further improvement of organized forms of medical
service for the urban population. Sov. zdrav. 21 no.5:13-17 162.
(MIRA 15:5)
1. Iz otdela organizatsii zdravookhrananiya Instituta gigiyeny imeni
F.F.Fa-ismans, (dir. A.F.Shitskova);
(PUBLIC HMTH)
GAVRIU)Vt N.I.p kand.med,nauk
Role of the nedical-nur e as regards different organizational
forms of registration-in ambulant polrlinical Institutions,
Med.sestra 21 no,10133.6~36 0 062. , (KMA 1614)
1. Is otdola organisauii sdravookhranwLtya Mookovskago nauchno- i
IseledovatOl'skogo Instituta gigiyeny *meni F.F.Erimum.
(CLINICS) _.
ZAKHAROV, Fedor Galaktionovich;j d.; MATVEYEVA9
N.M.,, tekhn. red.
[Medical care for workers of industrial enterprises] Medi-
tainskas obolushivanie trudiashchikhaia promyshlennykh prod ..
prilatil, Moskva, Medgia., 1963. 233 p. (MIRA 16:5i
(IABOR AND LABDRING CLASSES-M&DICAL WE)
GAVRILOV, N. 1.
"Concerning the Real Zeros of Analytical Functions." Thesis for degree of-Cand.
Physicomathematical Sci. Sub 1 Dee 49, State Astronomical Inst Imen-I P. X. Shternberg,
Moscow Order of Lenin State U imeni. M. V. Lomonosov.
Summary 22, 18 Dee 52, Dissertations Presented for Degrees in Science and Engineering
,~.n Moscow in 194 . From Vechernyaya MoskyR. Jan-Dee 191+9.
Pounoff
"LiapOunoff,,StibU1tT of Systems of: !4:6~nr. Differ
ential. Equatloiss'.0-7'40 I. Gavrilov, Odessa State U
ipsni I. I Ni nov,
"Dok Ak N&ukSSBR!.' Vol LXX7
LIV, No 3, pp.4P5-428
Considers, tbs' ar iem dx' /dt P
Bye ik(t)xk
Ikk-summed2from"L"'to"In';-:I,wl.,2,..,n) where P are
continuous .(in. 9sP!Pal% complex) functions of a
variable t."7.'Zstikb3-ish4is an effective auf-
ficient critOrign.lor the", Liapounoff v&ab It 0
the: soln ~'(xjsb) O-f thijl~ ~Uya~jo thit d
closes the stabilitv' for both pos characteristic Alum.
berr and also characteristic numbers equal to zero.
w,4 corroborates certain results of Wintmer, Weylp
V. A. Yakubovichp V. V. Stepanov, V. v * Mioroshiloys
i. M. Rapoport, K. P. Pe=sidskiy, B. L. Demidovidl,
&nd V. P. LBasov. Submitted by'Acsd 1. G..~Petrovskiy
'27 Mar 52.
s Stability Jun 52
In ~: the 2heoryI6k. Stability, -kccordJ=,-',
t*IXMoff 1. Gavrilov, Odessa State
1'. 1. Mcbnikov
"Dok -Ak Nank sm" vol 84, 'No 4, PP 657-66o
Considers the usual system dxi/dt - :Pii-.(t)xk
(k-svi' ed; i a 1,2, .. n), where P:Lk(t) are con-
tiiia-,418 complex functions of a real variable t.
Di ~- es the method of generalized character-
IsItSi7elom and the criterion of Persidskiy (L.
232T87
Aersliskizr "Iz Kazan Piz-Wtemat Obshch" 11,
Subm'itted by Acad 1. G. Petrovskiy
27 Mkir 52..
2"7
GAvRn,ov, N. i.
"I NOW VAthod of Investigiting NonliDear Differential Equations 14deb is
Based on the Theory of Momenta,* Dr fte4kth Sci,, Inst of Mathematics, Acad
Sol Ukrainian SSR, Kiev,, 1954. (RZbMatg Jan 55)
1&=way of Scientific and Technical Masertationv Defended at USSR Higber
Educational Instintions (12)
SO: Sm. No. 556, 24 Jun 55
tl ij -t
Call Mr: AF 1108825
Transactigns of the 7hird All-union Mathematical Congress (Cont*)Moscow,
Jun-Jul 15b, Trudy 156, v. 1, Sect. Rpts., lzdatellstvo AN SSM, Moscow, 1956, 237 Pp.
Gabib-Zade, A. Sh. (Baku). investigation of the Ramification
Points of Non-linear Loaded Integral Equations With Various
Parameters. 44-45
qaavrUov,_~. (Odessa). New Method Based on the Theory of
Moments, for Nventigating Non-linear Differential Equations. 45-46
Gagua, M. B. (Tbilisi)* On the Completeness of Systems of
Harmonic Function's 1116
Mention is made of Keldysh, M. V.
Gallpern, S. A. (Moscow). Cauchy Problem for the Equations of
S. L. Sobolev Type 47-48
Mere is mention of-Petrovskly, 1. 0.
There are 4 references, all of them USSR.
Gakhov, F. D. (Rostov-na-.Donu). Chibrikova, L. I. (Kazan').-
Card 15/BO "Some Types o.,,' singular I-nt-e-,-,-ra-I-Tq-ua-EFo-E-s--.~olvable in Closed Form."
4S-49
,~ I ~- V ei~-, / !-- 0 V " /V /
SUBJECT USSR/MATHMTICS/Xfferential equations CARD 1 / 1 PG - 732
AUTHOR GAVRILOV R.I.
TITLE On the stabi-My in the sense of Ljapunov for the existence
of vanishing characteristic numbers.
PERIODICAL kat.Sbornik9n.Ser. -C.L 1, 7-22 (1957)
reviewed 5/1957
The present paper contains the proofs for the theorems which have been
announced in earlier papers of the author (Doklady Akad.Nauk 2AL 425-428
(1959); Doklady Akad.Nauk �AL 657-660 (1952)).
INSTITUTION& Odessa.
LUNW, S.I., prof*# doktor biolog.nank, Otv.red.; KOVBASM, S.M., dotsent,
land. Istor. nauki red.; PAZYM, LoLp doteents kand.geologo-sineral.
nank, red.; EIRILLOT, Te.A., prof., doktor fisiko-matemat.nauk,
saslushemayy daystell nouki USSR-, red.; TSHSZVICH, V.P., prof*$
doktor fiziko-mtemat.nauk, red.; LZONOV, I.G., doteent, kand.iotor.
nank, red.; TOROBIYET, A.I., prof., doktor biolog,nauk, redo;
GATMOV, N.I., prof., doktor fisiko-matemat.nauk, red.; KOROZOV,
"A-.A--Prof-;-doktor khim.nauk, red.; DANILMO, X.Te.. doteant,
kan;'filol*'
SWi;; og.nauk. red.; KIGALI, K.G., dotsent, kand.istor.nauk, red.;
OV, A.M.0 dotsent, kand.geograf.nauk, red.; BABICH, N.M.,
takhn.red.
ESclentific yearbook for 19561 Nauchnyl ezhegodnik 1956 g. Odessa.
1957. 388 P. (MIRA 12:4)
1. 9dessa* Universitst. 2. Daystvitelluyy cUen Ukrainskoy Akademli
vallskokhos.nauk. zaveduyuahchiy kafedroy fiziologii rasteniy Odeaskogo
gosudarstvannogo univermiteta im. I.I.Nechnikova (for Lebedev). 3. Za-
veduyushchiy kafedroy istorii Ukraim4k6j* SSR Odeaskogo gosudarstvannogo
univers.itets im. I.I.Nechnikova (for Kovbasynk). 4. Z.aveduyashchly
(Continued on next card)
IQ oft IV A
oil jz,
all .9
IV
GAVRI
jqY,_NjL, prof., otv. red.; SHAFIROVICH, M.D. , takhn. red.
[Scientific yearbook of Odessa University] Nauchnyi asah-EINCUk.
W-i~
Odessa. No.2.[Faculty of Physics and Mathematics and the
search Institute of Physics] kiziko-matematicheakii fakulltot
i Nauchno-issledovatellskii, institut fiziki. 1961 197 p.
1. Odessa. Universytet. (MIR& 16:10)
(Odessa-Physics-Research)
(Odessa-Mathematies-Research)
GAVRILOV N. I. [Havry-.Iov,, M. I.)
New method for Investigating nonlinear differential equations based
an the theory of moments. Dop.AN URSR nc-.4-429-433 161.
(MM 14:6)
1. Odeaskiy gosudaretvennyy universitet. Predstavleno akademikem
AN MSR I.Z. Shtakalo.
(Differential equations)
GAVRIIDV,, N. I. [Hayrylov., M. I. I
- -----
Homent method in the theory of non3-inear differential equations.
Dop.AN UIMR no.6:708-712 161, (MIU Up 63 1
1. Odeaskiy gosudarBtvennyy univeraitet. Predstavleno
akademikom AN USSR I. Z. Shtokalo.
(Differential equations)
GAVRILOV, H.I. (Havrylov, M.I.]
Method of moments in the theory of nonlinear differential
.equations. Dop. AN UPOR no.8:1007-1012 161. (~W,, 14:9)
1 Odesskiy gosudarstvennyy universitet. Predstavleno
akademikom AH USSR I.Z. Shtokalo.
(Differential equations)
z!4-6j =Irr (m) /T/F11P( t)/EWP(b) ~~:,-IA (c
a 10. 1 N R AT5018033 l,R/903)/63/OCfjl/002/ooegtuqa~
J
.,.!Tqr,6 -Bauldr, T, - S. -, Cavri lov, N. T. vo lor, i Ps
er,7~dl;c- ~4on of equi librium S-,! i", S -1
Baku. Azerbaydzharskiy gcsudars~vennyy ,m*versi~et. Uchenyie zapiski.
Ser`:ya fiz_Uko-matematicheakikh nauk, no. 2, 1963, 99-1-03
TOPIC TAGS- -Salid-S -cr
e_equilibrituxv
f~o 'th-
MS R IU __r
1hpi Wvyti ci e which was davelope'l i4 . e
equi pment
of end1lbriu-ni solld Solutious by slow crystallizal-ion fi,om the !ie Lt. The
-trn e nt is z?ppllcahle e,,ren for th_~_m;e :E 7~ _'v, :crnpos :~n ~ur_: ng
~f t~e nvest:
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txte meat, in.which the rate ofAtiffusion is much greater than in the
17-7
i. Ccrd. I
e i ~urriace ~r, Pvac,,a'e," ;ai
T:-Ie -imj ~DU WiLh standard
I ar c eA
d
s and thermocouples were mounted on 7he furnace cover W (Fig. I of;
ithe Enclosure .
5 To pro4uce a more unifam tempe rature in the cavity of the furnaces,
a 51.ckel cylinder (L) was placed inside the cavi ty. -he arti-AP lescribes the cir-
nP
indicated that they
Card 2i4
ACCESSION IlRt ATS618033
consist of two phases. "The authors express their gratitude to I. IvaZov-0raskiy
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ASSO~IATION! Azerbavdzhanskiv qosWL4rQtjimnvv
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Wh lor 11tevirsilrd fly pulthig 41111111 -it agar lectivircti The tithidle
k
Mil
o hi
e
t the
node
I
I
h a
st d
T .00
ois-
ofill"a
o
ou
t
i1
t.
. V.
ilovo-A. I. Pisramladtvi MM
X.
o
turv
r
. a
as
a
"
tUT
g ~66
' nitho%lor rve "",11her-At 4
orl. (:. A. 30, IrJ46-Althimah t C sliketopip-
IM); lovidein hydt,olylAtCS CAUW,% 111ith PtUdUCtioss .00
00 slinn have, only a (ethic terulcury to migrate to'the calls- of Nils, whk-b iq more mailictl with a Ail then with a lig
00 ode, low-licaraciihe grmpslntkkehaimstuaterWI)rineream
f hi
i
h
d
id caslockle. IV. V. S. Italabukhao-Poptativa, N. 1. Cistor.
979-
it
DW
il
1
s
l
F
k
A
P
h
fli
nd G
Y
o
.1 -
st
r
e o
tbt* transport to the efectrotics. The an
y t
a
s.
as
y
a
un
.
.
.
ar
.
ov,
.
j r olli
g
00 3 -i-~ b die, which is markedly bask. wass.'ound to isaftentittly to NO.-Daring ionophor"is of hexone liossics, valint. slutounic
the cathode without decompa. SIMI with a velority *P-
stis
o
dr
l
ls
idi
Th
i s61 and sispartic ", the current it. shoulif tve excred 11)
to 15 m
am
11
t rvaction of the voln
at the
/s
cm
00
o
ere was t
o
st
ne.
y
proachint; that of free h
y .
,
.
i
p.
q. 4
or dissamination. Aspostic " anhydride tinder the calliode shossuld be kept achl with a current of COI but =00
expiti. cesmi(issms (Coi.pism" through the win. in the mLimlaMsfavwdcsaminatkez(gantinosci&. Asper. o;
cathode mnPartment)v acted like the anhydride of glycies: lie " migrates vcrr Slowly to the cathode. With tbk Zee
so and wu YM little dhv)cd.; at the cad al the vipt. some Will strong acidul2tion is neorrvary. InMvift =0
0
h was found in the sortoole and only tram in the cathode com- asuituillon. Dipt)(kIs4Iuuetiflrt!y lolitecathutle with-
I
Z- postment. In is mixt. of tyrut%inc and the anhydride al outhydrelysi%. I conditiosisavelavorabjeforionLu ac.96
pit
2900
ee Alycim. a small portion of the tyrodne snorted to the anode of dipeptides (acidulation at the start with 0.1 N If'80.MW
' .
00
0
I COS through the valhissle
solo.) There is on
"
M
= 1
.
.
.
, of Nit, In the rashjr w4u. at a current d. ad 10 1 '400
in. amp./ Cm.9 If the rturrut d. rises too 11 to 41) m.
) 60
strip./ em.2 tberr is A Slight ok'%AMiUAtiM inilkated by 141
the appesensisce of Sinai: quantitticis of NNS. F. L. D.
'Eli
0-
doe
AIM.ILA ARTAUUNCICAL 1.1111414101 CLAISOKATIGN
too
100 0
144040 or I too.) .41, 1-- lot
---s
-- - 1- 1- _r-
-1 - slisso
,(
j
U kv 00 It
"
'
t
, Me IN 9 a 0 3 0 0
0 0 0
0
o.
* 0 0 * 000000000
I H. I*
"Stud* de la possibilite dluzw detemination quantative des fomes cycliques dog
anbydrides d'aminoacides diapres la methode de Blanchotter." 2ayrilgv. N. -1. (P. 809)
30; Journpl of General, ChealutrY (Zbu=al Obahchei Khimli) 1938, volu" 6, No. 9
0
0410, a,
0
0 0 got of 0
w a "A v I it Q it 411 0 0
1L.&_A -A -k- t. 6--s-
to tyfwue m A, produced in the a
I!Mlc 1
?
Composition of potelmot by A.
'llorilli a Gavvilav. Bilallvi-lya 4, 1:11.) 11
n, tyt(Kinr And tryll",
kfi. we the most, C"IY dcWtIcil fi"M
o,1,1. by I ortiM. Ijjp%4.d0tKtllC*fthiS0"I-
J+"~j J,y Irvi-in. the ph-
-00
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j-,twinnertic *64 111ti-tv lLl%w wil- tr,t, 1~% -00
Aoki tyl.-Ille as*
aeo
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goo
00
eq
j_; lose
let*4 e. ties
00
ties
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J,j OR .III A J. .& g ii.0 9. A-41- 'so
'A
-40
go Ittlmelplabitily of the mitupleell diltvtopipetmaints
i-ig", A 00
so it 41-a;ned im?th Isy A61erbAlen (cf. C. A ~ 21. likki: 21. -00
V) anal by Wakisrhmidt-Leill. ft dl., (cf. C. A. 22,
3419) on the fernirwaVon vol simple dikct*Matine% -00
a When tirditnt with anill"t at N) . Signple dArt'l-iver -00
Amint% air frmirs"I "ion r IaNtr to tryp4nunaw, CItvvi
lurivir i. hyd"4TOM in W hm It, the extrat 14 1.% -00
jithlieAw. I'fylmln anil etepoin canowt ImImIrt,
so a It. Pdr,tky
so zoo
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Alm SL 0flat 1,114f MCA 1. UllgatUME, C1.01,01 CATIOW too
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go
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s MOWW~Ro&y al the biw9l reaction si a metb" 61 1
00 ft 1. , ----
'x of OM9100. I J~ Ljd!jN'
w A. 1. twisp
*0 Gavvew.. .4 - s.4. -410
.00
RAIWt Of ploteWytie hydr%4y%ts C&U tie tk-1,1. by * %tudy u(
8 the abomption qwtrutn of the murtt mection. Ily .00
CIM11"Wins The Mir of Int-fraw 4w f1rctraw 44 the stubmw N
so wilh the 47haliar in born-iov,4 the Wititt wa. ii,"s the vote
btaft,"I. all 1w V.b4lstul... .00
00 8
so
woo
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yzt-" too
Mew
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0 0 w ev 0 o 0 0 0 0 *1* 0 0 0 0 0 f, 0 o o too so 069 to
040.00 0 so 0 000 0 0
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ome ot"IST-66 -Pogo
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pot
Mir VON R
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so
so- ps R. T.
'a I O's I CA 'OftALS'"Wai
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IM&I Sol "T Ist
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ft 0 is a 9 A a 3 4
a,9 04 6 64-6 Cs 0 0 0 0 0 0 -84
So
1 r
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W.WM~wz- .
- -
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lit OLkp-lmg W91113
"90110141 omit
Oe i
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04 0
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lilOgYrt
".
,
ze%jr. too. a. mtt.-
nw twowki t. baw%t ujuvo ti., %00
Of rmpling at Mileatiml %ulfattilia"161C with Octiviathi 2 R
-
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l -00
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urnyk
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,
i
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l
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i
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or
mmetr
c drtn. CA the regultm
g POOMU
coloration
9
i
c
htb
l
01; am
n
tlap
a
"W-3AAh"Ifonic m6i). ChK tv. the
sola. bellngenvAl. for streptockle Is diGuttired Ivy trating
1
0* with about 0.2 kv. Of a 0.6% sol", of N*N(h ao,1
0A cv.
T
see
o-lorp 111CI. After testing fur free JINLh with stanh.
1
Widt Pao"
about 0
5 cc
of X&OAc
ol
l 0
f see
.
.
b
.
n. am
.2
tr. o
.3%filk-of the acrtYlated2ft"I ar
l-I
d
Af
r m
r
.
ter
The develmoromrat of the red color the moln. is cliki. to 11) cv.
with X
OA
W
f
i
S
C
r1, and a
ter 13 m
n. c4"paml with a 11)
m
1
i
l
a
f
"I
% see
4"t
0
ati
e.
m
n. o
ar"go
t. M. 0. Moore see
Nee
see
see
See
A a it a 14TAkt~44 trtWVWQ CUUNPICAM see
too
t-
malv OFF
- - -- S I aw a .0 A
V
aIt It
0 10 Is V 0 lp jj
lt
It a
: 1
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~
0 0 0
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R
GAVRILOVI N.I.
"Device For Determining Lewme Area" Dok. AN.y 24, No- 5, 1939.
--r.- and BALABUXM-FOPTSOir.!,,
V. S.
"The Characteristic Autoclovic and Fermentative Hydrolyates of Gelatin" Zhur,Obshcb.
Khir.. 10 lio. 7, 1940. Dept.of Organic Chem. All.-Union Inst. of Exrtl. Med. imeni A. M.
GorIk5*-_R_eC-eTv_eT_1_7, June, 1939.
Report U-1627 11 Jan. 10,52.
rr r r rr r r T WIT i1 3 1W ji 9 i ii ii it a
r a a I IL L a K CUT
M ago IND O*Otos
**A
see Sts hois it j -1 Auww'ml syedwals of dlkoft-
time bound to as gatise add. Kh. N. Lerman and
0 J J. Cts. Cbros. (U. S. S. R.) It, 127-32
LG
V=v of the work wwo I he pregm. of dl
SA (~ r-46
tuted on the N of amino acku.
filpkeresive won pe"id. accordift to
A i bratinf, 15 g. clik"opiperashir In 300 g.
P-
bNO# at 140 with CICHICOCI ~45 9.), followed by
bmt* at 13W to =An. of the startles material And
cenCl. Tbelifteredandcook win-saveSM
"MOW
Cr"d. from xylese, it m.
tion of the ~bovt win% attempted with various rr-
SO A
eel to. lomb". No urethan and ItiNCOXIfillh, but
t Fh, 1: : Will
tb uniformly mg.remIts. Pis Z
asive "a provd. t7 boating 6 j[. diketopipersaine in xy-
Oese, , 11 1 In, M. , adding PAMCOCI (15 W.) and beat - Gee
W at 140' to "novel of 11C1. On Conlivic 3 9, of Crude
SOS IwonmMeetyl - Ill . was otitainni. Oystd. from ben. Zee
0 W I . frov, k 0. two*. Amination wov maul" un%mv-fid
with the gap to ghvn show., Attempts to *minute
0014 the by Squid NIfq gave free dibctopiperoxise no*
41 -- flestles of 4 a. of the bis(ekleco. coo
-0 with 2.6 g. NsOAr in &be
1. Mrs. gave caudderable free diketopilirmalne without 400
Indication to nectlas cd the LICHO) It we 01!0*
10"dtbattbeclintbin. pd.lbxvit'. t
I-To go*
to
At.
b..Ab,A MZ~ was woo
d
a Itop"Watoodille j1W =Xpdo. by
Sim d
Wlvvy%b=TWV sely free Ovipe line" were ab- MISS
toinvd.
we 0
1�101" MAP cpv Got 5111"Off viskal me 6.v M
AN I I V 1W 0 14 6 1 V IN 9 A 4 3 0
I'll 9 1 0 a,, In a,
9166496
a No a
I . A, I
0 .0-0 0 0 0 0 0 0 4 0 0 0 0 0 0 0
4
16 U0. - 0: 0 0 0 **so* 06
0 0 0 a 0 0 0 0 0 0. 0.
0-0 We
41 'go
0.0 'Septal,14 -#I
see
A -to
'a Ova
of 4""1140 lee
o =14" by "kimptim'W'.
0041
ISO*
,004 "il-thir -R4111"m 141 111P.-I hit:
00
so cv,ill I
ex - --.' 1400
Ood Th
10"t 4% for
OOW minalla)nq
0011 "'A h
L,,,Yrt-. With
ter 0
go
i~l 0
400
ZOO
1300
lose
Iwo*
U71114111110, CLAIWIC&
iLll--L-li -1-- -iTli---;~!
ties
119.3" -fit ONT 449 ....... tree
a Alp 10
it it A of it on 01 w
it i aiK 134 "n
1-0 -*6 0000
0, cp
A
triltic"I only when Ph is in dimt
I. I. dkfft
The rot 1 c1 caniltinatiom with she C of Co. Ilipt,tatine hA
% the Sallie
n.,
-
"-cltaia mrsiecedaills. Tbor.0 fiev, ph t
FAIty mricl attlidrs ate not r.fu4md unless
iselle
_
V
K 7
.
=it Subismism1~0 owdes. %. 1. Gaytilumr. A.
so, Ale far I'll repI.Ac" the It in 11COXII, co, -Ac. The
X11'.
T
M.11")
sti
Itt
Ivist
(cuft
Irl
1
.
-
14MV&
yu,
unit M. It.
i
r
, 1441taktioll Ill 1111.1,01il. uW 6 all rtwpllm. 11l# vvslrf
ban. S.W. 44400. 11. 7 ,a UOVO). -IU
belsaviortsfalcaltles raw u( frilucti,01.4 mr&ttalk. cuttillil" is pffAlatily dur to
is
to
.bly
rbittliser cydk and
in ciectrureductitits is stud" to det. 14 their gemater tiew L4 hydiolyA~ awl she -4Y - 14 the cmpd
4
ep, ~Ics "n Le distinguialsed In Pristrins. The
,"-chsin
o
j
d
j~,.
p
pro
.
p
It. M. Wmttr
ejecumles an purr 11b, the &no& milest. 6 207. tW4,
the *,b,,,k be, 6 *),,, HA 3ulc* 111011,45 -, 110"D4,
11.111 U Allifile, cotle"t it. is 41,187 alills./sil. on. at 40'.
"
like . r"lur-
Voller the" 4"Hitth"J., Over Is prewth-Ot 1R)
Is
WNWIt
I1*NII tv
) A 11M1
s.
.
t.
tkm qa the atmor
CIL
mem, I%.-rbclltLo% ,DCII,. ROMFICIIAW!,
ale
A-V at f1cmim. &5% fm
frdtictioct of ACNI'llit. .9
IIMV-
I,- 111CONUN 118141 4021c, 1W nC"s-
41M
A.
~
2
.
,
INItcloOlirmiDir is vesnipletely seduced to
too
POPMAW. \0 miuctloct Wris-
PhCI ICO*%l I Pit.' PhCllCONI%. IICO.XII,. . AcMil. 9:
Ac.';Met. RtCO.V%Irl. ble Etcosphr, ill.
~-
:t
611". StetCHCONMet. bt 17"' MesUICOSM. in.
4
lNiz I4,cIircONHCHXOslI.
-
CCON'll
N
si
o
et,
)
t
W
. "
It-
"
4100
I.- L X.(41
hyl.
lecowl t1jW ive. M. IU3 4 0 (from uthcuc I
134-6*
Kie(h in RttO). sot N-(
m K TIMAS
i
m I
3
,
m.
fters Ove
(2
% Ar
20
too
0
See
Any 1
logo" map
*31411 doc a" 1%1
7
V
0 a, 'Pe V 94 An I ad a 0 V I V 111 4 3
at W
,
1
:
: 0
1: * 0
0-0
-0-0 ~ : !! 0
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00000 0 :0 :0 :0 1
:0:e
:
V w W w W w
11 10 W
11 19, W. I 14 VIF tiOlta bid ft
JA
A
en 40
OVA Vvwjj~ de mwpkbw by die Sobalevit metliod-
t 0
1. GhubwS A
wnd XimikAr. 1939:
xm. 4. a and &-Vnwn clkvkn I the SOWCVO nwtbOll
hr14 he pmm of 01-0.0 MS./nd. but was un.
11rom cm by "Wdom cl the in the
WSS tbwvfom coffwted to
'11"D ids. T1k lNuffic
prop. Axiom
sic NO
atki 1.6 ad. 41 9d",. ItZ101 (Vol 11414
add Is a U) ash AAsk mW czclt: OWL 9 see
91 ":*I= 1 .00
Id. do 4) lwm th" is no MCOM 10 txcm
01
*.U. ,,.be pi.. tM W.- w be
test
temed. To a& of the tomt tube add 3 W. rA Ow di- age
W"., IA4.0 ad. of lip, Ow 0m W. of 10% M1.011.
Kap for to wk.. &M HoD to w4m 10 ad.. OW cOMPAM
in "Wb obtWned by this metbod'
'III d catudsmi. COMP"ed tO thc
intemtkml matiod bw a-phine, this w"INA Isvit.
meww1at bisbow results. Nt. 110fth
it
Ole
0O
N
I tvtrtr *4 Ord itim Ocatac Itx I INA v ft 9 As's 3 9 1
000 0 0 0 0 0-00OW0.6,wooo a 0 0 0 0 0 a 0-0
, 11 .
?.!oscow Stsite Univ., (-1946-)
"Methods of the Estimation of ',iflorphine according to Soboleva,"
Zhur. Analit. Khlm., No. 5-6, 1946.
GAVRILOV, N. 1. Prof.
"Present-Day Status of the Problem of the Cyclic Nature of Amino Acid
Bonds in the Albumin Molecule" 1947. Moscow State Univ... im. M. V.
Lomonosov.
GAVRILOVI 11. 1.
"The Present State of the Question of the Cyclical Nature of the Bonds Of.-
Amino Acid in Molecules of Albumin (Diketopiperazine Structure Theory)," -~
Vest. Moskov. U. Ser. Obohch. Houk No- 7, 1947.
e4 ----
lot
.A __ __ gkasn:", f- CL MAI.
A,, A-A., f.. L. Is
49 MV
gripertOO& (MOOWOOW State I A.0 0*00# 6 14 1 .Us t
rv arsil A. V.
17.3m 010947),tin Rulinlain).- It is 1xiamble that m C 6. 6.1nd fill a
0"",. detal. a aw d'hel,nAp"dal" (pjvp) lier"pt in frilloper4life ill IhAt sitiv ('I. Iiinspol With . ertmallr and
A junthaftjird "liv, 14411this will 1whicyrd fly Wwtfvlytk the %pill" Willi 40111ple isvililloa.1.1 Stullmly, let III imily
1rediAM" to a Its Cathutlit in add Milli. (10% if ), of orw C "say 1W INKIndAith 4 1011talwilihir ill title Cifilh 4
fHCOat"'. Under tbasmemulitkats. nopopix'Will itivepilde mid file Isilief With 4 (hpullikir. vie. rhevive. .00
ma-0 am no Por Wh all BMW * Irwriluirthirs was Ot,""siplOwti with a lit vatt"itir Air* tit. .00
00 11i IM till. cin., c.d. 11.1114 stntp./.I. vuk.. with an and. ;4
If dy*; no 1 11 We Its wr" , only VKP.
III anit N11 gimful- xre dirt.l. In Ow *iq *44 Ilk Ili* 414#111 %lich as Ilot III r%jTr%l I$-# hm 6Or 1-4al ii,focli-al. -09
00 T. liphimlymed I (4,441s. Lit full I I'll$( is 66"1 and Other "ilh 1.4:!r CT",
00 owt nairduct"i by the Mornwii and by The van ityke onstfut"I it, jwffi~t .13 'filly IMI'lirrifills "fill I.M.;- itild -so
sairthude(C.A.24.2772). 411"'. IN*). b. !N1 AM 4% 1114, 1110 ill., ruld Mornwit if- .00
gnino N content lit the hydirtilysird mlov,10. fuld In thit trishibillty to( itur N. Viumfi-mg -,( the viviti,ist Oitrmitr
00 kydrWywd original litoltin givell the sutt. at the DKP N (2, 4, sind A aml-. Pit INN -,]. vin-1 114-1 ito rift, I itif t'w
ee 0 wisiaauy Prevent: the van Sylit "Wthod #IV" this amt, 1b.111. 4~1 file jilt 14.1wrell ~vvll% is fill.
directly; the .46[enwti dells. 11111st lie Inullitaw by 2. 115atury; "tith 11111W211"llip Culli.4 Its stir 1"Ittribin 14.
siorl MR ON ad litiegatine is litratalor by two rmthsml.~ ,,,I imstuph-te. A Irtisp. 1111C It 01-111 -0' 111SY C411W by-
00
volt
14001 IMP N ("five fullwal N) found YM1 drokysis sit the warin; a tilt, lowre ihAit 2.5' t* itimudi-
.= Iletit. t4 piptiAtior kit triluert)
00, T (1) 27.6; pwdn4w led adstis (0) 28.2; tient fir the 11mlactital. let
00 a mum alburnin (111) 2t.fl; %turinfroultale(MIL4117o For I was attemided by way tit elerimphrigeti%: hower". only
twit OKI' tise" are In 14 num-wyclic jOirptifka. (;,Hl a. abilut halt ill I lie fiscal still, tit pilictillifir f. tran4ttir"I in
in IV 6. Xlevircstrolsivii-in libirtairs free aillbso polips In.. thir ill tit$ lim, CIICI.
Is the amt.. (4ftv"Wit. vast AvItri: I N.2. 9.211; H 9.6. 13.0. lully. Ill hall I-Mil 1wel.l. 11"141 WAI fill. hillitz's 1100
In 13.6. 14m; IV hA. 0-2. miter crittiffustAtums, 123 fill. %ctmit Aviv 4"t-v I.Ittil. isith
-1 'the" atut%. rettlain"i us '100
MMMOM dialditsed in Wmer- Centrifuged Mal vidimsted to fte
new see . peinhim, of flit. of t fir An. (esint a. wtm is**
the ripl. Aplivat titer of lite Nil 1.
alter utfurtbin 1% rvi-Itillir, Ollie ill filliturr 44 the lawill 1w4
twor" the helif C Oil PA I, as"I The enel N d lieldides: it the 11111t lit stinjivian by
Ili$ 11*11"I as sialfalt. ();10. was tiftj file tle 0
Iwort, the viristitial I.Aid btivirelk IJXP All'i the prptitt
"IS emb ralsw kill. N. Thon
Nll ClIk
ILWII C(R IS, V
[ , ~w t
RLL
~_+o If
U 9 A' 112-1i d 3 a V
442
Is o 0 o o
WEV X - - . - . . a a a 0 a -
_4f~ j- ~jj ?~jj ~~l 0
It P idle 399 U10641 400 6~94
-A d , L-AL b , 0 J_
A. 1- 1-111ML-1- ~_~Jt 1711 =~~
i* L a %a
AN
PSOCCUIS A.4 PfCO(OF111 --Vt-
so*$"vo -41 now and Ilibililli4w Makka, M, -0
( 70i:
Rakow of plaide. A. V. K7
C,
00 _roov owm &&to Usiv.). j (USS.R.)
Rudea); d. C.4 JI 33W
"doctlow SM , , go a "0 as lee
MIW" Id 47 sq. ca. wM 4 esp.. IN 10% RCI
ton, of the , ion IM &M. fron tin
=WWO tM tboure" a" an aftevol"d
ow. of IH6; Nokia Mol volop achis wore Won ho swo-
I wok IN 73 al., Mbw _1 4 , .00
go A I Anklos 1 9 age
art - rodo" r very monly w: SoNI16
040, a 98%. 1011%. DiNHCNXOJII
am MOVOWS b PbCli#CONII#. Blum 6 not.celoced. 00411,
Dor an the Amino, wids and 41pept
Almislan1w. lyralow. arioulne. h
Nol try"Ophon. cystkw is red =q =t Ve pgo*
toe"afte In so Min., cysteine is not th"
2
IN WW or In NH4)H aWn. GIrrylalycine anbydr~k
(2
'a.) (0-3 t) in so tw. Oleo mi la tra.
.6clawasteducvdin hrS. to the Cittntolul.61". Sot 0
Poduct Ow kleotifirtl as PiNfASIM. IXWY1JeUCine
anhydride (0 ) in 75 sW. 16% IlCI was reduced to See
tlweztentoiivtodfisobutylp*msiw. Redwtiouol We 0
platio (0.1".3 x.) In 76 sol. 10% 1 IpSo. was corqkted
Not. of Ila coummed Corresponding to
L
about 27% a( tbe total N: thm. conw.
it q-*dY. Is the Pemotar of Ow cyclic diketop
Z N
In
we'll
N
Avadva mi# C"V a" 1p
10 #W a pt it 0 Al 0 __%
4 a
U It AV 10, It 0 4 It 9
lp 0 Op it T I
0
21
T
T
T.T TYTTITITITF
m AbD ta ese... It
z
o
'
,DID --eV-sibumolmlar wdft of POWM U.i is typical of SipeptMes'. I The It I I I wpi
"to-
'
e0 ! f
I I
14
di
C
h
L
fl
l
w
sso
ve
n
i
4
a;
ti.
.
too the lUttate (A) rit
y
Itiftewatka of sobst1tvied damisplilareshm WO m
--p
CUjod Alb-, remidue (01) otital= 7 c-fla. Cie 16 C4110 IWM.. rt-
a- 1, 7
Go"
f
6
, ) jtj from AcOI31 ml Dom front MeCIII, st" 2 1.
2. /
Our (mikko Cwt. oj a7dd. once
-
00
e
0o
o
T
0o d. e.A. U. 11M.-Tile Pon"tY 41 & occurrefti in protfuct with the correct N content awl awl. wt. (at I.S.
s
of am of Blatt tit 4 POWW Fk6jei bgtwm III- di-Fj filer (M-SUCT.
== (1) and an "Abo arml (U) b dbmmd. al.1410,verymi-inif . Opts. with pkTk acid,tims
a
n
TI
ti
i
d
U i
W
-04
on.
o
W por
a pot. Muret react
ot
s m
out mg. u1shydria an
LbAsp between dw N of I Ilad dw CWl of
(Pn) whkb did not d6Wvv In C41(s was re-
f 0 om the bub of the work of Lamme aw ckvdl*v (C.A. SS at The %.
l 00
a"4. 11,0 to 111" 2.5 X. preduct with the correct
,
WN). Lkkwbct.tv tbatoolIWImirbourivolipal
d
I
f
S
A -
S.
or
o, N mttst
and tiat Costl of U 6 ruled oat bomm than COWP
8 with pkrk acM. mW I derin. Isolated from. (TM. m. 3400, ml jol. In Hav, pi picric acm,
00 r == do. :-(Cariloxymeth or a $IV" tg. and a pas. bluret reaction. 1 (3 g.) and 4.3
t-
d mthepalcan
1
ISO
d
t
h
l
d
1
EW
b
I
S
d
*00
.
a
reac
e
.. .0.
.
.
ol
. t
. s
. ( ),
y
dale. the. oL4AIwd from
i
I
0o give a ppt. which, with lioNCIIXOM gave 0.75 a. of*
!i mW(COC?)s(02QX.)d4 mot react an r4ning 24 bell.. pmdwt.VU.(Cojl),.m.138*(fwmAcONtaMMeOll),
0043
"601
1 11 kA RtrO. An nothemic rubcdom. between I S. 1.4- Insol. in MO. ppts. with pkrk &M, gives a fieg. almobt
C
pas blurvir"Wou. 1(3jj-)mnd4.5ftd.(
a
.
li
s
a
a
w
6-
)t "
m
w
r
is
o
m
a
i
x
o
(
ia
om
~v
)
i
o
Ac~?
9 f i
r-lts-j
100
. 10DW. EteOxddedahw the beat dreac.
m
mbed
hko
e
m
w
a
d
a
I
COm w
v
e
C
O
ta
Pt
t i
P
t
O
ss
P
E
7
r
n
l
:
0 '1 Q . chkAutim product. 11V WASW witis timmi 11 tho tuixt. refluited 48 bes., the StoOteplared
! 'R
MNCJ`lr~ xMC4110bereduzing continued. the Ciffs reum. . IIA
' U in ment
and treated with 2A 1
O
l r* o
.
,
t.
.
o
COVITt in NUO lpve a product 10.3 ji.) having the coe -at a. I4NCIftCOHt a4ded to the residue In 150 ml. RtrO and
N coffitent and raw. wt. (Ram) at Z ;SOSbf4-(4vb*xy- t - fatered when the "othemic, reaction hAd guu;;4.
'
I
!V It 000
0
lth AcOEt (which dismaived abowt
/o of the V0.).
; so
Fj abr=. in. M
fonmuf titer; %/s of the N appeared as N M Solo. in. C04 (wbich disaulved altmost nothlogi). and MeOH
"0 0
S Neoll foe out hr. Wbm 5 9. W and & mi. (COCOs In . (wlkh dimmolved most of the PPO: the Goal amend.
j
-SI40wmniuiL*d%4bmmWtboWambedW,trest;!d-tuW out. TbeAcORten.wasevapd.amd1thervoldve
-'1 I
A
) taid. with RteO, # cryst-com
W"Um, ofItaNCHmMRt,tba
(
O and AcOE1
*kb the em"act x cm t in hot HA Et
I
ld H
O
"
i
d
8
f
.
n co
&
,
m
. .
at
I
a pro
wkb dry MCI 4.
C. o
tent mad Md. foe k ~ (3--. It IN Mbly
n -taw
(MVW"* Mr
NUCOCO)
CCII
C971t CO (R atO
H
d
i
JU
1r
~
o
-
O
I
I
a
o
d
.
2 he10
The WoOH est., Wd. with 9W 3.5 a. cryotals
In. 1421, very sol. in HjO and MAM.1boodal. lm 140 Wtj,-
a**
Wis. PPft. with *Tk ". contains a-, Sk" a POS.--
2110. Powd.
#1000 OAt G- 049
malmably V0
kb
*i
it Is
d WO 0
.
a
a reac
om;
W
y
U S At 00 W I t " I was car"y ground with loss #. PC6
; P I I I
3
~ 1
It It
1
00000 000*0e*ooeoealoo;[Lo-&,;O::Oooooooooooeooooo
:1
--lub 0
0 0 0 0 0 0 0 0 0 0 w0 00000000000000,00ft
------------
_Wwwww nigogi~gao-ii;;;;
*~r. ditat S days with 6 SIMOuty, 8.1 S.'alaftim eth
the 2,6-dibydro4OA4IkA1*r;gr&dw (EK) ester-Ha in 30 mi. KtOlf and a g. IX ga
p9n mkLAed usase dild. with -e.Vbdx)dA ) J%' -Fj Is
cave MCI 2's4b(I 39
wi Rum 11 in MeCO di 541",
d "i-Ane. M. 60'. sol. In 160
CHXWt. The pera. .1 T W.W. with . 'i =1 00
elm in Co.. - a y 'W
in f-diusage. IDI-Et amputate.
Ila Jr.) In soft with 2.8 g. 11 gave 37.3%
odd "Wadva of I ""' ~Wvw..P R; 1&4.Fj esW
Ob Got 6=4 MAN FE" w D: 20
9 L. N. Akilmove. This
1W. IS WS-5MIMLT a 0, M,. 6a. In &(,611 ..4 Et6H. insool.in
p Strom I mW Pas is U~btd (ga the Ifewco. Calts. and Ew. rq1j7V lydne Ur
I T J, lOws"hubtarir 't'-Ila (Not 1.) in W011 ='t Oxii 00
tont wivni- CUM and CqHA
Oftlortri yldtdv,,
1130,
1441
0 w1imay. %%Vte wm
o' POC 11,
= in.
vety
Mo sto . in". in rat"Ptior. Rua, Colls. MVVCO
its greattr Wy. IN CCU SW
Axis. .
micro ang"
0 0
111
It (mm 11
dk"t -pe
Rw
nir Pri"00 C"Cls- and hydrOmbox. The
tulactiou
thl bbmt C=Pkzu Of ioam of th
h 0
-
o
,
to
090. 80". dK*W~, 06 110140M. W01- IS UMI
OH
h M
i
CO- '08"
MW H e
ave
plotled " fewlime at x. [y. L= M=
405&
b
d
0
O
'
t
sal. IN We dowly decouip. w
00 dosis got 61" Amiga N with [too. aim a me. radio *
a
WO P1101111 and 101tedial J". N. D.
Ul"Alf. N. I. 10-dwriloy And L. N. Akiw4v%. fw 00
0 with pktk add. And a p-- biuret rewti". fOr-
M
ycift
Oswego C1 as all trans Which, gin
LIS with
-Ila
d
l ~
9OD-71.-VU.211a in 0.7k .4. win.at PH 6-7 was M
h
yred by a 91111wal ext. at canine Intembw mucVft
jr
0
,
c
M
00 can be recriltd. Since slk- by" IS timi
citlotr yd" at X of tooth, Its, TMwIt a ve
g
t coW (
).
A slotillar main., contg. (),I!~ VOID. was h
drolyard to it* extest at 23 mi 26 . so ter 6 and
to as 1. vols. (M N&oll) of Cxa. wais compared with
that in a 111011W scia. coasts. pure 1. Aftor 30. And
Amiga
f h-- in 0.3% Ha, 63.7% after 24 hn In I" HO Z9.-
21110 In 0.7% sq, soin. at PH 7 was'h;~'jr;:~ 6y Ar
t
th
00
at
99 t:o wk. 13.6, 30.6. and 22.6% X Upe
N after, 24 h,.' bydroly3b of EK In N N20H at
f After $
l
t
0 o
e extent of 75.9% in 32 bm- and the Pit felt to 3.
TIN WrO Ove 0111Y ureak tests for I at d
WAYMIU
To PhOO
h
00
-
ye
w room temp. sbowwd 02% s
0hydralyew Is 111%, Ila at 1001. 79.0
1 AN
h
U& P
ydrol"Is was 64,
VAN
Arte In 13 It". la,
tresiteol with 0..'% Pepsin to
1 00
twt
atten" to asp. the k
:0 jecdog an sq. win, rix to'=1ywIz o.
w
b3
Ink a 3-eqnspart- %, Ila for 14 b"', wag &)q by"y0a; the hydrolynte
nav* a str, ff test jar I god A empletely ate
bi=t trig
So am cill for 00 bn. Was MaNKTISMIUL
HaNC14MEI.-
h
d .
~
see to have an "aroldinase'. activity.
~::=
e
t
M an
MCI (11A a.) Is 20 'mi. U0011 MINd with 3
" 91%
09 wilss. toned. is wee And PPtd
= in 1r
, Ov "Cl'alm"tnest 1111110.1%fla.solikh
N@ ON Ar aminoww Aide C I... Issiving the I tins
l
1420. Att at daig
#mm .*AW- V! L-ki thin "amidlum"
activity but has a
00 VuJHCI, M.
to give The dibask WW XV)s M.2110 dtw 01110" vatillMy far by&Wyzkg X1 to a dipep SO
in dde, which is
00 mouttiss is transformed to the tautome-ic fwuw b1drolYN4 by it twase MT.- Dan anthe 049
419"Mic b7dr.0011111 $9,
00 camod.. m. 126". llft1w at.I00*;F.;-.w= h1hroin and gehlia me later.
Preted As bsiliMing the Preftiocr ofamidlise compile. 1, 00
00 the lau'd prMet". J. P. Dameby 00
0 O'S Q'0 0 0 * 0
L'O 0 0 04 0 0 * 0 a 0 0 vl~_ee 0 0,04 0 0 0 0
*0 14
*04
00
09
oig#
44-4
Too a
96141
guano
V. bw
d.0-i
(tw MOAMP. "Oder 1w
-
partment. " ww 11i ad".
swatutiab aa^ afthe
14 =Udit-b
phoreasolaw.opluaw
1, out nit. lbrouga a VAN 111144"
9111131111 3001knip.1 sit" lishm
Metil was (fte ~ at Morowne: with
-b7diorlik"ht!
$110 "dolamp. under IM V.,
:A=wl
aftcr 15 hm; U04t"f MIng.
I was ft*Adwfw In 40 ofla., 1110
with a casm. M Stream save a
owdir tho maw w"flona. but
braw, c"pletv tramet vm Allabloid
opium (a a.). ground with 20 mL
r odso$Nw"W - W.V. dw scraw a &W&
ad -ban k" oploss aw e- M4844swoviii 1%
OMMM Wet R. Aco Dan.. was rM from murpUtic In The nibUk coo-
Onot - thely.). political pilot 10 )~-Jw usUNAMP., the 10"p. d"s
M W-W14417)(14 Rua- t-neway to W.. Oonw N*. 14111 cowthrold to .00
-ftebov . 1W w. 6, in the cathode couspertincut on twice revvUed ft.
IV veamp =4 Jffl~ vAwd of tha I% "it catholyto and twkv rvpcoled 6
U-11) 14 .--- lim, ekwtvaphurciiiii.. the Total pro"I contained Mg, .00
#a JM) morphine aW 305 mg. SAMNor. AN14 a Pei-.
It-vilM forted qrocedwv. iarniviagrwilb fraWitaltatval TheImp. -00
16"kieft 101
W-M at Xv wift"p). Al the isful. of Atoll. and -00
P 44 wA-). Obw Twig* ftpwed dvMcfbcrcv* uVo W% of The wwrixNat
obutwOw
owhic to Ozo Mg.) and UD to ILSM Of t Marectine (9p -00
rm., in
toduou Wed"
the rive St"toir 6 1, owutn) could be Kvd.; I cr of moo
UM*
Wit (3 6. sittil. a the atter to tathode requirn ackifficliclon witli AcOl.
&~sd tb~* to. vAb tat (4) "Blectro*UM" wat Obtained from paw
nb
UN=MU
mmambimddmo cztd. with 11.0 at &)-W' 3 hr*.; The t"hic we* nit 41141114110
V.); the authwedw- alas for I hr.. with 2% Atoll; the e41. Wait evapd.
, 1. , attisplecdams: woe
of Aco", at "* at a r!m:e nil's I-AV.. of-t
't" cents. ramphloe kToo
AC40M WM.
d1l't V111 a celloplidiftil nwmbMtw. ft Miliode) 46abiol dktd.
,VMkw Water. Under a OMWU Ut CO.. ttalp, J&-W* CWMt feath. Woo
the lag 200-M milliamp. idler it hr.. Total duration 6 br..-. 6*0
t6 hot add final ant. of warphiftintbec2tbolyle23 (yield 7411) COO
(2)VW&kjbk - - is ;= Till,
Reploc-C of the PI cathode by 11
.... 1.9r-
e.g., 80 nil. of tit. trout dry plant mocriaL f 74.2 414111411
boo% "114 IQ-
mg. morgoblor. with a Its cottimle of 62 sq. 6-MV
N ~~ -
3D% gm wMilemp,.. move In 13 W. 974 mg. margobloo, (yiclil
W" AMMO material wil. with 1140 and Ilia tv*-~ v*b woo
= "31%
gave under the lianis condiflaim. with &I *Sb"a
IM% *M aft 1111116; to SIAW% *W at tampicim. CAmPlece of tj;'
ofilli a pmbmwft
in 0 The cathmic compartaveat reietabio doutly
P11=10 uns. (6) To def. ii d1pontlow a t goo
4% AROORN, ,b. WOMM.
0.1% mutual%* WW wAn. in 03% IIA04 with a 0.16% -7 woo
2-11 NO ~Lx W'j-AA1 is ado v
0 0 111 0 41 0 0 0 0 0
a's 0 0 0 Wo
W's-le Wol-o 0-0,0 0 0 0 0 0 0 0 0 0.-0 0 Wo 0 O's 0.0-i0 0 *.-AA6
P-A-low-G-06-9 0 0 0 0 0 0 0 *a 0 go 0'0 oi.*!-O,O,O-o 0 0-0
00
00
go
00
00
go
go
00 rm -ps oi o% wmr
00 FO"U"OIPMPMIWRN%O
01 up *"a 0 -1 IR mm js Impi
v p W-P
WeN PD. 17P1.:
so
00
0 0 0 0~: wol.o..0 0
0 0 0 0 OW Wo~
AD,aI
00
go
eke
as
.00
00
00
0
06
I lisle to
A ` a &..I 1- 11 1 1 I-A& A (9 Pit
00
00 r
11 11 Jilt Jill list INJOW Q Is Oc
I f
I-Go
am;" M., 1. pIckhan and S. 1.
a roe
oew 'i2 zoo
Dox I!!-
roe
law
0 :1000 0"
tloo
we*
sea a%, &$I
she a n a 1 9
so
0 0 0 000,00 0 0 0 WOO 0
USSR/Chemistry - Albwdn May 4 8
Chemistry - Synthesis
"The Structure of the Micro-Folecule of Albumin, III," L. N. Akimova, N. 1.
Gavrilov, N. D. Zelinskiy, Lab Chem of Albmmin imeni Acad N. D. Zelinskiy, Moscow
State U, 11 3/4 pp
"Zhur Obshch KhiWI Vol YXIII (LXXX)., No 5
Describes synthesis and properties of 4 5~- dichlordihydropyrazine. This was consensed
with the esters of glycol, alanine, aminosuccinic acid and diglycolglycine. The
adsorption spectrum of the copper complex of the dihydropyazine-bisdiglycol-glycine
ester had a maximum, corresponding to the free diglycol-glycine ester, but it was four
times greater. Develops a working hypothesis on further possiblities of transforming
the micro-molecule model of albumin into a macro-molecule model.
Submitted 13 Apr 1947
PA 8/49 T65,
GAVRILOV., 11. 1.
USSR/~,hemistry - Albuminj holecular Structure May 48
Chemistry - Fermentation
"The Structure of the Micro-l'blecule of Albumin,, IV.," N. D. Zelinskiyp N. I.
Gavrilov and L. N. Akimovap Lab of Chem of Albumin imeni N. D. Zelinskiy, Hoscow
State Uj 3.112 pp
"Zhur Obshch Khim" Vol XVIII (LM)j, No
Describes fermentation of amidine bond. by pepsin and Intestine juice. Submitted
13 Jun 1947
PA 8/49770
a 14 k t. .3 M o v IL, ij A ;'r0
p , 9 IF I I ~ -W y 1 .4 so ii~ M tt 4
A
Cf. C.A. a?, 0113k
as". IN"
d 2
2
) .
g.
5.). It lot. MAO. Ne
:nit I till. 0.24 -V eott)Avl, t,k:.Ni list. mmt it Asnuic).
lisfildild 1WO46 A
the sold
olin
ith
d
i
t
off w
.
co
xe
g.
lem m
VC4
nit %vottifusting. The fillhivini wor-Irtigth% ill inAp.
K1
i
case
n $KOO, cl
Autow also filter, the IRW -ild-
# atilsorption &all lunfat r1linction "setts. were 'AlwTv"t.
it move train The viaduct with Wr- ethm- the ligail"O
rise the "'t-416, till-l: AW oto. 00t;
Vlotmisijr. AK.I
%WI
1111111; NphrothnAnji.1c
.
.
.
Naoll spit %'A a. 011% -7141yetne in 2,8 mt. N N*Oll 11.145; invi h0nshmAnMe,
I
o the sell". *1"
with th till
It
fin
Af
00 Z. .
.
i
s ).
(wall , -
ter
11.140; Nlkw. 0.17,11;
aliecipd, "fatralind with 3.6 nd. -s N fict the RIA) layff tulde
0
W
111": 4nullur
W0
0
111161r
1AI: (11141titilis. roe
.
.
.
.
.
.
.
VM., the water evapd.. aild tb;dy ;~~ Wd. with jiuret MI.O.M. 1 [$%*COCO %I full, MI. 0.:M; AV
.V*- zoo
.
hot MtW. The: n6awalvid residue sea% taken UP with NUM.N111
0.1-6111; 11191141lisle
00 .
o
^q. 11goli. dightly ftWitied with Acuff, and treetteit with AW, 0.211); ollrysinillanildr, NO, 11,17a). 0"oplete sh.
00 j
! it In plow.Kt u( INI black tier 45 rairs. The mixt. - mpt cufv" Ate given. rise sasb1litill kill 64 Mr. lit.
2114111ti"t, Theatall-
With 5111T011
id
l
fil
d
00. .
,
teM
.evelpt
.. pp
yttrwye7filydne M forms a bluret complex with a red and irs inctesuers the 5tAbility of the CA mn It%"*
x N Dictitylosamide did not rmt stith Qlk
CuroAc). zoo
-
Sell
0 .
calm 2201 contains no Cf-. 1 (0.5
r. darkens at 2110". M. Is the condit i de"bed above; its compkx wits
Not c
treated as Above
MI
6
d 0
i
4
MA -200
~
1 .
An
.
a.
..
.
m
(armed bY heisting the noilde with CUtOAc), fit Mr
%,
I ed with 10 1. 11. The jj4!Any1t0aiycy 'Yeine (MI Rion I., 1W jilul olowir .1'I'ling V1
tiled after hpinwitatioll Pirr it M00-4; 1 'AUtrt ~Abwtpd" aWfts of solutillno of c*Wr com*1" of
.
*
off
CU
0
Tan"Pte" 4" Ill enal"i"'one
till
*,S- The 1411"1
1hid. 04111-4. CU V1411111r]"- ill onin
pew weehr W. Tho is lim etiev" for R. III. Itall a 0
Add$ Were prefid, ill alk, -RAn. (cf. abovc). ThcIL41,rauss
let 4ide (flat men own the twW 4110-7= trip Willit-IM011% 01 Mae. llb-4ptilin and T1101111' t5ttlaClillts
"la= wmtLm. with 2 max. at -M-M mp. .14milar "'effs.. Mp.. we" W.-erit"t Pic the li'leti- MA
Z, isher, fact urv" are Ov" fiv Ili~ Morel 01
a Iff1wokle. and be twist I defiv. of 141wriseltit ""xilar. 1110. 1).L311% still. ITA.
mnin CO 1wr ""AT I
01111111111a. salaftm at eapp" tioil kulven file givrs'. %%hrll -b", '4 Cis o-ollsiftes of
"a . 'Alltsumfint, xl)Titlc. and hyllps%yvalinr %TIT %uhlocicil lit
pa. W trite Cos Pkv-
'4 WA clectnAy-i, Cis %sr.., f.,nn.1 t.. jhT ams,te,
Si owe pf"d. by 414. a MIAt. W The a 3% XOH.
Imis-liv
I m -~ p
1 U fiv so
9" 0 0 0 0 9, 0 0 0 0 Ole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
~--6440-411-0 0 0 94 0 000 see 00 4111 - 0 - - 0 6 0 *to 0-0-0-6 0 0 0 0 0-0 e-O-O 0 0 *011 0
AGO
S414
1146411
USSR/Chemistry - Spectrophotmetry,, Proteins Oct 48
N Spectraphotometry of Biuretic Cmplexes as a Method of Research
on Proteins: ~Ij, Absorption Speotra of Solutions of Cupric Complexes
of Several Asides." N.A. Poddubnaya, N- I. Gavrilov,, Iab of Albumin
Chem, Moscow Sta'W Ut 11 1/4 PP
"Zhur Obahch 1himm Vol XVIIIj, No-'10
Investigated absorption spectra of blue-violet Ou complexes of
oxamide derivatives, violet Cu complexes of malonamide derivatives,
and red Cu comp1mms of biuret derivatives. Submitted 18 Sep 47.
PA 2/5OT60
GAVRILOV, N. I.
N. A. PoddU17~~aia and It. I. GavrilovP Speotro-photometry of "Biuretic" oomplaxes
a,-, met',,od ofAnves ties tion of albui.-ion. VIII. Absorption spectra of solutions of
"exes of uLLno-acids. p. 1860
copper cor.;) L
The amino-acidc form copper complexes with EL maximm ahsT.-ption 610-63Cm.u.
It is proved by electrolysis Vmt copper enters into to the Ln~on part of the
coo-,-vr comnlex.
Lab. of C' e-,-,istry of Albmn &,oscow State University, 11
'older of V%e Lenin Order
.eptember 13, 1947
SO: Journal of Gener-aj Mic7istry (b.SSR) ~Lg, (80) No. 10 (191,8):
GAVRIWVO ff. I., Prof.
"Delonization of H2 at Low Pressure," DOk- ANi 71, No. 2~ 1950; Lob. -
Protein Cheinistry Im. N. D. Zelinskiy, Moscow State Univ
Mbr. Mil. Air Eng-ineering Aced. im. N. Ye. Zhukcyvskiy.
Akknows "d V.ZJ6, -V. 1ARTMOODY State UOV..
b4i. Vdoh S.S.S R. 73 1 IWQ2
V
Moscow)* Ad
of the cima, bw6vkt ;I wyktcd
4119WOZ:lAsimes indicates a Nude of formation of the
POPtide h t6t 6 WA MIV. to t#* MO-Pr rWt1M of
ydewylk dm -pipm.42ine. thus. tt~
h
at 1k v 4" P. t%W"Y1dHAftO
111 111*143119kkut. OnAutbly vilth Intellnedwit
MIX of & C14f"Powins WWI of Nils stimps ot
tWCO vmp. *kkh riuming" to 11m, lamtrtir 0,0-ill-
Acdetriv. by imankrufAtigmurfromM totheOll snuipe.
the resmawmat Imadve tow votautouOy dt*m
eitit" into awn A* *YA AtMIC14COM or into
Wit mid 1. to she. RW fbe lattef reaction omis. I
whim, ak. JIM Yields FtOAc and l1j%'CllO-'0XllCl1,COr
It. A slWAW YmIlon wh% lyrominit Me "Irv Itives a
Clir N1f.C(0ll)VAcC1ltMfft
mr-mmet sumbitamiII to I but much man mabir dam neither
InWi6ewhittOlldneekspikofflItOll-, t6mmilamts. I . I
of the to,"" I ader obtAmt as a by-product. tiowev"
Imilesto tut tt vaction tornm h similar to that purami
by the shelft ififfiv. The Irw--- analog of I with sk.
IICI npklly Wvak"MaO vW to RtOAe *xd I
"tow t2 it* ,,C, Nit).
( t
yiemed
art-
tlw 0 1 which was not c"vvd by
IYOXY171NIUmto-
it aralwo of 1.
sell, getras -"M- Wid emer Ykid anakw of I vrith-
out on "Atonts"I"Ith formation of RtorC-
COM111'"M Ion the%
NPH HIM t.
c
A"If. soak
S.S.R. 74,
R(If4sillill
the pommiWity-ol existence of the protein tool. structure Pro-
powd by G., d di. ( I'Mmik Mps*,v Vvh. 1941. No. 7. 67-
84; follmag sbvtO. Cvatg, diltvtoop"W&W awto hewks
uValiulm betw"= %=e pArMtkie CWM The VeMV
bumsfer of these JV-3cyl VMPS into elolodume %,Ism da
CO carries an aminoacyl group may be the hmp to tW On-
tbmk of dw prpWc chals. with cilligtopip~
latervesdiate a"Ky. Ileatins 1.9 a. M-9VAW
ewridemwoms-dikittopipmLlintlit hWlu'5qE&l
Owsterbalb lben5hrs.st142* save83 1
. p. 4C4H4-
.fter ;;;" with 11.0 Et "If. WW 116
SOOMICHICOCI si";ruly Gael the 1-('
dfjWY04.$-4Ad#PiperQ*ilW. ul. -",* (Analysis 'Ovem is%
of a TWWWACYlated deriv.. COIIAMN.S). Pb-
CIIM%l[Cll,COLI in Ph%'Ch (0.5 hr. at 130*) savt the
I." tier
i
ftFh.N;ck)! I I wftk Ithi"
ClIgmit in RtJ3, then treated with dry IICI after filtrutim.
UVX"cttd ester while extu. of %k original MA, W"
r4= I%d INfT)vC-IIJCHaCOlr
H k ~.. I, ,
at), mall.
Mxv. OR dmTW or t t WOW ft an
pm 17-110; no diket VMS IN
llJc.N'll.c(OH)R
the
"Mo
grME3
"ItIlCh "tt-k the r-lurzj
dli, ghcmw
struetwit Ot Pteiffin miclasuallicall; V. Ac" of
P"taCb1or1de an dLket.
~Qv . R .C, PrtruvA, and X. A. I ubtuyA (Sfo%mw
Stile- -~VV) 74m, 06thcArl KAim. (J. Gen. ChM.) 21.
tallml): f CA. 4J. 37A11tt.-2.&rXkctC prnutloc
Usi
(11 With 1". let,.- irwtv. vinkh
.t jjt,,_ 1,,.1 1.. lit., iq.tillat tit 11,Amulil, 1wodwim. The
.lievific condititmi A,-urlng lbrit h4mat" I-ve -4 tweU
worked out, mm-". o.5 it. powd. I &W 0.4 g. PM
carefully tfiturAicif together. heated rapidly IS 40 mi.
M. In the prrvimi,ly descritted app.. reftted 3 lim. cookd
.jit"nit mv, .4 smi.turr. and 1111teird. gave lnrlkMhb
rty-SIAN. (III dmunp. :01'. flivin
lite trAcq~qki "t I And tolatillig Its lift. a tilpept4jr whicl
ykidi I% efm4cfrtistic Cu root tell. The product was im.
pule, 2.1 wene I cty%tds couhl U %me under a tnkrtAcqm;
the matetial coutd not he recmfil. nor could Its InOl. wt.
be detd. tlevatoc of its lowly. Sintitaily. I g. I and 8 C.
KI& In 40 fill. hot Cliff Pvc much IICI; fiftering the hot
mW kiting
lain. after .11 rain. without ac"m to ITM~Sttkft
it stAnd I hr. jAvc 0 7.1 X. nectilk". decomit. IWM* and
analysitur &4 alk-vr; the mit-ro-callic aTt*AMW wall very
simil4t tn 11,N-1k hU,toA0-dihv%4oI,Y"I ne (III)'- the lwal.
awt WAS 201. lit t-Ithl 11,0, bwfuo Antilul X.. And Itratment
k O-PO.-O N
with Mcoll peccuoled with 14r Ice and leffiali warni up to
10-15, Ito- 1, biJkleting the can of hydroly", of llw P
link an-I little -howing lite Iti.oln, I w#* tha IIIA. Imi 1--ulAy
an mler of the w+I with an etoll form of 1 (11111). Treat.
*#cut Willi (C(XI), t'lijed to YiM 11CAl. ralwTied rnr
?be amide formulatinn. aml no reacti4m tcwk plicc even in 6
hr* Trralinent at the jwminct in mlif ItIvO with lf~
NVII.C11.141 4141 rttqt~ with Pt.0 hill, 1.
OV1.11cf.dul-111,11%.
am h It an r,Acr cat the ~*J. -i,-e neith,,i Re j2y%!trA-&mktine
our X-P&-phory6ted alyrine Et ever owe vowm. The
'structure rJ the produce refnains unknown. VamscrembilAt.
IMP12 Were 111491C 10 CVAIJIM the bMt OtIoddiont for the
twelm. of III 1#V file IdkjVr ff.4,jif"j. In C.11. the tr44-t4mi
'AVA.l."1411V I"If the vk&l. are hmt-r thall In 4:0,
III AlrPh 1.04 It at"I III 14NI'l, It prnhwainAl lite, ;11
Itent4ne or cIrlohmatic fit,- rrwtitul 'It" not go. while III
lio&-Itant a PDOOF 11AWC PftklUCt I$ f0fultd. CUIllit.44% Cf.
Indicillng sorm ILL No reaction occum in pt-tr. ether. to.
W--#O*. while lit hexane is forined a chlorinAted product,
2'. which tftccxnp. in itir and gir" a bittert reaction.
tn. 120
In AcCI It formed tilefu4ivelY. Albin. u( quimline did full
facilitate the mactioll. I Wa's PnIxt. by divem tnethadt
6% a hilift dep" I,( putify and wai flied in the 110. reaction
with the ftAlowinx leull- the Ittmiuct. iyutifiel hv "in
frolit Pb%ltt. us 274". Ill" mvi mict with KNNO.. with
KI, giv" both It and M, slid will% 14CII der% not met at
all. trulk-aing a completely keto fiwtu. 1. ft(mi the di-Ij-
Ae deriv. and If,NCtfXONa in 11A In. 314'. g4re with
PCI& only 11; ittlaiNtion with ultraviolet light failed to after
the result. I "I'L from Rion .1ad dried at 110* St.%
inve otl1v If After 4 hm 1-0. ,Ih he -6-Ae -Irriv 0%
CO. IrAvr I"Ily W11.1ye ustr". 1.1 m Offi it, 1"1l III It hill I
/IJ-7
;face 4 Ill. tit, 7W 4l"1 fne 4.1 1" W.L' obtained. Ill i.
"t pfepl. ill Co. Isom thoroughly d6ril (15111'~ 1.
Although eval then It ttLly 10fln'Uccasio"A It, VI. Prep-
Welige, at
imerless; Mil
lbak Gq f IFO;"nljv ;WIT '%- Aklentiv..
INd. 2M-94-Ad4n. of 27.8 ml. W`f! NII.Oll In 43 min.
to 30 S. MCOXCIIINII'Alct in 10 ml. 11.0 at - 109 VAVt.
lifter 48 bM,M)%2.54i"pjpmatjw(I), Wgjand$c.
PO. treated with 70 mi. dry CCJ. (for app.. Kv C.A. 43.
3-1")- -PWIY twaled. boiled IA Ism. cooled filtsved
withistat acef" of mokture, and washed with C13;' gave
95-7% (11). in. 330 , am
I-011'. II(I.51.)"UallyrAdedto4.6g.tynwne?.It
"tcr IICI &All in _'i nil, dry MeOll with ke cooling SaVe
-the poorly 3W. di..Vt
fjw-211(7. in. I:r-,* (froce, C110j): when CACI, is used a.
"A"ent- the Fent'llivIl dOe's not take Place, and sionee glyrine
dif"'Plide may be i-l-Ated. TrrAtnwnt with IPbCH,%WI
Virlds the
rOx ) 1320 (from
0~110). .14milatly. ll,%CIIAC!rN gave 2.-
ifi-Fj #Wr-2ff(7
sale. in. 10". r- MeOll-Eloft attempts to form the
9161,60braWksly dorip. under viseeksuss consiltionip,=TlY
the cormpoodinff deviv. of Ctyt*. m. 1190: 1 its a
reaction run In all, %'&Olf. Apparently the acylated
Andiline kiles ROJI and the glycyl raidusp is WyUted in &
Val: lose of The exo4nfe. Vn- Sienese beelftnallim of
I- 1.3-Mirewperaglaw in** noon WO am"
Gem =it meembels. L. N. Akimoves am v. 1. GsvfiW,.
INd. 204-31I.-I.4-DiacYlated diketespiperselismet select
With Mairsell rAitu am Werse Pei asini'm fis MA a way
that the Nile Foup Addl to I M-' g-P of it, Let..
P'Ppmsh-- forming A hydrate of the tuffespordblill GoWne.
-which lituletstmn tit,- tWilll;
she product m4y cittirt 1-c theacylAted .%mine with fo"nA-
tion ol the diketopiperarine. or it may kv~r ROII and form
The evit-
acv &led amidineq form Cis complete, of the tripristids: type
wi, ~` . 1: 1 ratio of Cis to the amWine; on tre-Atment with
Mi the sumMitirl form Cu %all- of the mvtYl.limilide
Inic. Rtfluxing 1,441ijcrtyl,likVt(Ilify-fAtint With OFSOM
abs. EtOll until wiln. occurs assul chilling rapidly. Followed
byomfdn.olit,%ClIA'hEt(L.1g.r-lc.pipemaine)pvein2
blS. X Pill. Of dikCt(J;ti=ntP (1). Lnd a salid. C,*Hn'%.Ot
(13) (eztd. with Etoll the crude plit.). that gives the
AtIll
MAYS"IC And the hillret r"Cli"M Of 4litWf'tiqtC tYpe
in. 1.13A 5.06 (from FtOll-Flol. sprmrently bir(exis-N-
Fj
ralleig.
I
CCIIB%',t) whilethe mother liqtKm Vicklell Ac.V11C1AC(NFJ.
in. 43'. and lf,%'CllCtfFtJICl. in. 1451. With Ain.
MrOll As "vent was sim"y obtained am I :s4ip
%'.CR-CI(t (R - 1f(WCIIt'%Ac) (W)I, C*11*04.Vs. m.
li-s-O'Ormn UeCO). and a little ollbe Uabm. aL 134%
sea* Ac.NIICIW(hFt was also found. Wbrm tbe reaction
Is run In Etl('#. M, m, 180% Is the principal p"yjgwt; if
Its.';CH#C(XMe is used the same III. m, "s% memo almll
witk AcN11CH,COMr. m. So'. wisle subptilutift ci 14,011
at the solvent Virlds the di-Me *sair a CmElftNij~,
al III, m. 142' Omen MvOll-El. m
- 11 It 91011-dry
IICI gave mli ionic umvected U. mW H,NCHsCC)'4ll-
ClIx0irt'l ",,,deconp. JKI'. Unelm tk - cmKII.
lions (I ht.) I , unchAnged while Its di-Ac deriv. yivIds,
-At deriv. of 16 days witb
AreEt &mi 1. Shakint 2 IS. di
3,44 g. tyrminr Me curt in 50 ml. &b4. Etto Orlded X
drelyhymi-te Me forr. M. W. am the tyrojilse Me filer
."lot of It. M. ItAo. whkb on sunding in the reaction
%ohi. sbaly yivM-t I and 11st sibarr 4V-amyh entine Me
ester.: treatment with MROIWICI yieldit
Jk.jAw-UO,m.942*. ftClIsMiewitlithaREAZZ11:17
of I in F1.0 rapidly Pye am I and SIM aws'atayffim"Jil
- of M M, 149' (from UVICO). a won a jagag
PhCANHAt. m. 410". Similarly. Frh% in SW
1.4-fads. 41-dia4rityl-l-propyi-s.hoboktfmdw =-7
AcN.C(:4-Pr- MC112. in, 176'. Wbich 2lft
mg. ninhydrin rrottim; no Ac.VliPr was lommil. Isdicatiag
A Ix"ble ubwncr ul an At ump in todo position. An at-
tempted rimilar reaction with dry *%*If# in Elio Nkd to Ube
place, pamAbly becittoc of ready ky%s o(.Nlf* by lbe tapect"i
.."1-011 julduct. *141ins the %Urting nuttrial in the
courte of the isata!km ttrAtment. Treatim. t of 3 IS. 1,4-
b EtO wills 1.43 g.
lIt.NCIICOEt for 2) min. pvr the
int FJ t$tt? olgaka of U. "I. I His (frm EtOAC). WO
i7rc
rJ11COMICH, 9. m. M': in EtOll as solvent. the
amidine could not be holated ajol onlY I-Pirmeratine mmul
MCCjj,j%'11s.J1(~CC11jCl, m. 106% meet found. Tyraosine
gave 50me 1 yrodne am Its wag at Cd
Ste ester. as well " the Me e1kr
findlOt 0( 11, M. too* (Imn NICTCO.-FtO).
0. It. KOWILOPOO
07 1 -a. I.
n
SIL ar
' ruct re of --,Acrolec-,O,:r units of mrote-Ins. Tr. Prcpamti~ in of cor -
-1. . tlli - - pe , Ide-
of 'he dllr-,-cL- _,-4 c neries and their acylatlon." by N, I. Garilov, and
L. N. Aldrova!Tp-.289)
SO: JguriAj gL Gonval. Choristair (Zhunuil Obshchol MhLrdi) 1951, Volum, 21, Ile. 2
GA71,1107, ' 11. 1.
"C'm 11-1
,,k, xturc of sub-moloc-ular lumits of proteins. VIII. S.-.)i-,e ', mmsformations of
acylated '11, 5-cLiketo-piparazines dmrin,cr -.-eacti-n with ar.Lnoacidz and arO-r-cs."
bj L. 11. Aldmova and 11, 1. Gm-rllov. ~p.204)
SO: Journal, of General Chemieunr (Zhuxnal Uoshchoi Khimia) 1951, Volum 21, Ilo. 2
nUMV, N.L. professor, rodALktore
[Protein chemistry; collection of articles. Volume 2.1 IhWI& balks;
abornik statel, Feravod a anglilskogo. 14oskYa. Isd-vo inostramoi lit-ry,
1952- (Oft 6:5)
(]Protein*)
Amino kids. 'Nov 52.1
vii~ne a of,Amino~Acids: 1..'~,~nthesis of Imino,
Ithers.of Amino Acids," ~A. N. ~6vkiheyev (dec)
and R. I. Gavrilov, Chair of Org Chem, Moscow*
State U
"Zhur Obshch KftimjI Vol 22, No 11, pp 2021-2029
A method of synthesizing imino ethers of a-amino
acids was developed) and its applicability for
synthesizing inino ethers of the aromatic and
(~-serles waz demonstrated. The imino ethers so
formed were comparatively stable in a surplus,of-
a1c satd with hydrogen chloride. Thig permitted,
23ax-35
the products of the reaction to b.e:-Sepd oi;t in
r. z;eficiently pure state. The effect of them
position of the Amino group on the rate at which
Ininc, ethers of it- and f-amino acids were formed
,vas recorded. A series of new imino' ethers of.
At~smlno acids WaS prepared. Representatives Of
the aromatic and j9-series were similarly prepd.
23ST35
'U.99R/Chinistry - Axiuo~ Ai:ids'
ff,,~Midine6 of Amino Acids I1,11 A. N. Baksheyev(deel
and, N. 1. Gavrilev, Moscow State U, Chair of Org',
Chem
'mZh.ur Obshch KhIm" Vol 22, No 3.1, pp 2030-2035
A series of N-substituted amidines of amino acids
was Bynthesized. Certain dipierates were sepd'bLit'.
In'most cases, these picrates were easily and di-
'ieitly obtained by the combination of the salt'of
dlmethylaminoacetiminomethyl ether with the picrate
of the corresponding amine in an a1c soln. The
238T36
tendency of the imino ethers' of 'at*-amino Acids to
form only m6nosubstitated amidines vas*noted,
vbireas 49;dimethy-laniinopi-op-.iliciinoinethyl eth6r,
irhi6 reac ing'ifith'~n-ilib6-"und6r-'anoilog6iii 666di-
tions' (dej)i6ding- bn'the r6i~Wnt -i-itio) -ieadily'
pi6videi'b6th mono- and diifibstitfited',amidii2L-6.,'-*
Thi treatment of the dih
. ydrochloride of suiinoiso
b4tyriminomethyl. ester with p3h~idine led to. the hy-
d,rochloride of aminoisobutyramide.
238T36
-7
1. AFIVOVAI Lv N., GAVRTLOVa N. I.
2. USSR (W)
4. Piperazine
7. Microstameture of protein. Part 11.
Zhur. ob. khim. 22 No. 12, 1952.
Some reactions of diacyldiketopiparaziness
9. Monthly List of Russian Accessions, Library of Congress, May 1953. Unclassified.
G~--XXUQX, AkhLwa, L.
"SySte.-;'z- of ar'socistion ai-~i ways of syntIhetizbv- noIlls 01 ot3in ':d,~rostructuros.
Ir. fron the 'D. 70.
(Analele Roniano-Sovietl'ce, Soria ChUiie, Series a 1.1!-&, v. 5, no. 1, 1953, Bucuresti)
SO: Honthl-v List of East Egropean Acce -.gigns, Vol. 2, No. 9, Li7brarl of Coniress, Septenber
1933, uncl
GAVRITAOV. R.I. (Moscow)
. Chemical nature of proteins. Biokhimiia 18 no-3076-384 My-Je '53.
(MIRA 6:7)
(Proteks)
.J
1A
Ghaziaga Abet.
Vo 1. 42 No. 6
~~r. 25 * _9U
Org-arde OlmniztT7
A 4slWw
n; --It hastietz ohowa that amisline and X
Unka4t, are po3sWe between dioxopipemities'
no acids Thus the poxsibil*,ty of hiteirl ofypciptide
link2gCS in protem I is eliminated above the trijieptide stige.
Heaud$ 1.1 t - S- arbogtyriit-- cnhydride wiLb 0.&! g. dioxo-
pirx~zxne in xyl,ne until CID, evolution ceased. filirring,
and W."hink [~( p"'t ith a little Cold HTO. ~Wd,l th~
ir.-k,l iq:,l ~Inv I gage no w1hydride or ninl,~dnn fl:~ts,
but d1d EkiLmt test of the bipepdde typ,& rafter stand
imf La M. F-'~%tpn_ of t1te aq~ filtmte gave, 4k-Topirwr-
in I IL Vj=94CL,__
L-9 cFvm stru -1 -phthgoy-
11tha
dfo=p(peraz!ne was edded C,~ZS T. %',!
EtOH. the mLrt. ihaken I hr. and the ppt. wikI MOIL
AA-d: the f1trate pre (Pewhile
the pvt afi~r !r-;-.rrmt w,-th an '. FtOH yidde'l crystaij
~er -1r4ed ni
20' ravid li-tint
$"pRjal~%J pJhIq OtjU'&7j
U
-
-
r
W
av
.Fu
=flow, ou "tt
qd
Pull
P 44ti
44M
*0
V4430WO
L144;~,
19 In, "I mi
_
.),I,l
f:'Ir 11, r" 0;
d.k ;:p ;,'I
-local
VTtV
too
1,ft
DU
wo v r
sm .19, M"
Ut br
bz
i-ard 954
RAM thtl[ tm' left a b"1140, it. of aartln$ ma
tha I fu r4p;~ VC X "d IV
21111804 (PM em" 41t'Qr SUED.-Irl
of Oro
110 an plom", T* 1V W.3 V-)
tO treated "ith 0.41 g - V,CHOCOCI An Ht
MM 1. lip .1. 111'. youl"I the die ba,
7
ICIANMQ"~= 110+, -hio x4mc no a ahy
~Ydmt t44;' ;be biwrt rqLcUm'of the trA
t C'4 4 Wit4 ftc
COQ 15mve Altm z;
4CCmp. WO ". fo Ji '.,zLtd giving * urg. ;ni~
it tom hiumt tr4a' and a Vas. W%bY*
-)% tt"m
Owd p4n-tm~ Complete I I treed of NaCJ. Tb~ ~
=00 In ft prf;sen'~ -4 MKO Imstaut of NR'O.
40 pxvdgc~ PbAcb v-- frml of 161s" by kti
Wel LIA, -A,". MOW the -Incd. bwovq4f
ve At Pos. Anhydride mud Dec. gh
Ctrum t tew The [wer run with 2
luafy)=. xeucz~ (bc piperazine ring: th4
W . by apecuuph,,tcuut try, which sbawl
; t. of td- muA frlr~i-wklcs. Th P4 I
dMVa to WjjCfi,L'O N RVH,C(.V1 blcf'M
'C11McCOMXCHsC(.)). -hich tbLcn plMt!= R!jT.
ANJACJII(:0~11. !Q-k ... s 2.3
I,IpqlizLrm iq 2D ad t., M011 kith Z ;. J.,1
flujopipemidac in L5 jul E'Otf I hr. rayc Ft(
I'll
'Zi., brramc bwstc. P-~gc of dyy 110 yirl4sp
Wt. C.311"MOO'Ch. d- '-'~ 220". giving IL tript
ICU. PIP*; aulrydrije 1-1. -d pui milby'I'lu tel
hatting. The pfqxj%L, I i %-Axis"I the att'Arttar,
It 0. Vi f. N11
N
CO C1 f. NU
M
('
Chemical Abst,
Vol. 48
Apr. 10, 1954
Organic Chemistry
AkiMo and 1. 03.17ile
Yal. V. Lomnnmv gjgte LIM I. hfg~). 84w-i-Obraorl'
Kiesm. Z3, 4 t7-29( IU.%3).-In further attempts to establish
Cl) the nature of ibe links of proteins to repkice the varticcly
simple pepWe linkap (d, C.A. 47, 2001h) the carboan-
hydride link was e3mmd. Such links can exist in the farm,
of ring-closing units ((rae anhydrides) in dimlated,piperi
azinedione structures, ot In the form of simple 1111car an-'
hydd*s. SeverA simple anhydrides ivere p=pd. and the
;fMWAtiOn Of OCY)OW %5-PtPC1%WaCdJOUCS UOM 111CM Was
estalitisivId. fleatiag2s. N-0thtdoy1jilMat (1) with 2.3 g.
~(COCI'h 4A Ism In CJ14 'T VD1,fi N-PWAOky1t1jWiNC ON.
Aydride (U) 10-allACUUM1,C01VO, tn. ql6* (from
PhNO,). This (1.9 C.) braINI with III S. 2,5jdPer"l"C.!
Aiow in PhNOs OJS hr. it 140* gave a pp(. of 1.4-bis(N4
d x nine. m.
102100 . M
YI&I fte
.1 K. (COCI)t in 144 1. extit. cJ the ppt. with NlesCOJI
U Iwaling the itivil. poition with syle-ne ve the mixeil
anhy*ide a~W14CVWC11jCVNH C111 50) 0. de-
rocnii. 220' (from PhNO,). I (OYMA X.)
n to mi. d* atie
mated with 0.4 MI. 114N. then at IQ* iri 0.4 ml. ]Rto~
'Ct. and after 10 min. with 0.84 g. I in dioxane. save 03Y,
lit. itlentifKA as H, m. 215*. Ttentment of 1.94!
Wile
CIl(NIICChCIfjPb)COj1I (U1) in dioxane with 0 mi.
V" t,N. then with 0.4 ad. RtO.M. wxl O.D1 g. M in di~
C%nim 7-1 after I hr. (C(h evehition) X(brxzy(Oxyr4r-
!hhvvl~?=r Rkydride. C.:jj"%Nj.square pkites, m. 143*
Similarly, PhellioeNlicif COSH (IV)
'trrjU(4I with CIC%Iit in the Uw.~wnre of Et.NZ in Wio=me,
tiven With 111, rlvr t0% (PAC11ACffl11C11,CXW (V), mi 1 1. 1
114' A morr &-itisfactory procedure, dei
TO(jX%1 later, (or Mint. of the Anhyt"Iel 10 111ttstcat"I bi;44..
low: IV In 20 ml. dinsivir was trrated with 2.4 M14
11-teiNClIsCUMes. then at 10" with 1.9 mL RtOtW,aad
after IQ Min. *11114.18 R. IV lit 220 nil. N Naolf, and the
Ppt. rdtitind after .5 min'. vieldlit 81% V. tn. I k9"! after.
Le M.
Ok butku Tht synthesis Is a 2-ste rett=4
I,, d1ocame M1.2 .1.
m 1~
cool* with 0.95 mi. Ittosect, allaz
to stam to mfmu mixed W 10 mi. If'o, gave much Cot 0-3
V. M. II0* Identical with the above.
==Myl anhydride formed initially ceacts either
with the Na saft of tv or with [Ito, Yielding the mme pml-
Uct M, the difference In (be 2 mactions being the by.pml-'
ucU. Tivaimentef(betuylozycabon),I)glymilfl)'-im(Vl)I
In d1unne in the Presence of RUN with HI%CC . then with
VI. as above, gave (bexsybx)carboxy1)j1ycy1 ax-
ky*Ms. m. 140* (cmde), m. 14P (from PbN ). which
cam be cry". fnxn hot EtOH. Similarly.(beusylexicar-
boxyl
.V=1Yc* tycise rave the wre aNA
21
M. I % ob only in ciude.tatc. Is I hr.
..witttO27s.tlycineandO28t.NaOllint5ml.tt
0.1 jr. Hs 11, shaking until win. resulted. neutraHn Witt,
IICI. and so mcxv gave 53Fr, PALW0*1 .me.'
m. 231*. = reaction with a miglycylglycine sare_
no bmlabk amts. of phthalaylgi Illycy ycyw
although a tobwptide bluret, test t L3n
was - GAI ' (0.37 C.) In 10 taut]. NaOtHI tc th
2 after 15 mtn. zave 75% VI in 179%
V ISTAW with In 2 rooks )v Moli ;;U~Y,
PC tg=
ly =t1gNW2e.m.Iq0*.-
G. MI Kosdapoff
IGANISIANI. P.O.; GATRILOT, 1J.
Forml titratlon with application of a glass electrode. BiokbWla
19 jio.3:345-348 Mr-Je '54. WRA 7:6)
1, Ufodra orgamicheskay kktlnll Nookovmkogo gosudarstvannogo
malverelteta,
(7muLmust
titration of amino acids with glass electrode)
(AMINO ACIDS$
t1tration, forml technic with glass electrode)
's Rt
a(,'& All Sluctural fc-c-
~~fao CCU,
r, IT. - 1~: N a ntut ' 11.
f ("In cl~m~ U.S.S-R,
40 464~f,
M/Chemistry Antibiotics
Card
Authors t Akinova,'L. N., and Gavrilov, N., I.
Title S Structure of Gramicidin C. Part 2. Study of the FormAtion of Cupric
Gramicidin Complexes
Period.1cal Zhur. Ob. Xhim. :24-)- Ed. 6p 10W~- 1078o June 1954
Abstract. Experiments were--'conducted for the purpose of solving certain unexplain-
ed problems,connected.with the structure of gramicidin in the expectation.
that this would lead to the synthesis of this antibiotic. 'Incomplete
data show that gramicidin.C has a piperazine cycle, formed by phenylalan--
ine and proline.- Gramicidin is a dimer. The molecule of the' original
gramicidin has tripeptide which together with coppar in walkali mediura
gives a complex with a maximum absorntion of 570 - 575 6j1,. The displared-
ment of the absorption,maximim, tadard the short wave bind, was -observed:
in'the amide7tripeptide complex, containing aisparagine. Five references.
Tables.* graphs.
Institution State University, mo*cow
Submitted
July 20,'-.1953,
'2-
-2-
vndenc-m the baul
d1oxwp"Allnib in Its metkd WAY e comou.-SupTied
-
tramtrilml tell
dk
t
(I
d
LT
d
t
b
i
n
a
e
, w
use_t4-___
m -
-
% ~ the
.) -an
y-
t
22W-7(1954): d.--C-A. 49i- -an 011tri c-
~Plllag IuSc, (O.T.) or an evacut,ted "- r4&,qp;j.
-037C.-Among the various te&ctk)ns be(w"n - IV. I I-Y itibe (H.T.) (in.pt, reportcd without ccmment ctiv tho
acet-Fe1;7x,,ripmz1ne anilirit,4 Is that in wbkh thtse licated frnm rwin p. in an opcn lube). Refinxiiij 80
1;rnied N-acetyl-Jimpiperazine (11). bh~ng I veith W. Piperazint (M), 620 rid. 11MIL tind -r-) mi 4131" CU 0
a
r
ddi
100
1T
l
d C1
4
if
0
ITICOITt '-emal firs. ilk Et'O r2ve on exta- witb Urr .
ari
.
ng
.
- m
.
~,,,'
jj
.
CC -,in umlated yield of 11. m. 180'. while thm .:In. yktdcd
8*
h
ik
h NQ44Q(hU-&t 125-30- O~ ex. Ov, If& fi.M aet-turle a64.
'
t
* acdtt
ester, m. 4
;. t
e Ke e~trr rca,;ts shmQOV:,,
CAU 9'
Ub-2
id
v I
th
l
I
I
Sh
I
I
U
k*
l m;,2%vL&*. It stirml with ale.
NaOll at town tenip.-pvt
e mAti
JU
.i
ri
_
W
JAr
n
,
s J
l-
k
i
*I
!
P
f*T
h k
fi
f
l
R
O
j 11L Shaking It with PhOIN11,4a a&4. RtOll I hr. gave
tvm
rs
e-cco
r
n
w
t
,
t,
ng ap
n gavtj
o.and IIA and M. 6-zilLir maction %1,1h buiNll ;n EMU rave the
PrNITAc. S40:%rly, I ind PhNUI(2 C. and IZ84., rosP-
-im- caf
v
vA
1
r1
nd A
N11Ph i
O solvVi
5
M
t
l same m7dt; no re-cition took ~iilci bctw.!Cn I awl PhNITt
.
l
e
a
c
n
l
e
g.
g%
t
.
G
U.
the vield of T1 "n3 tim-tated. PhCtTiNT`I#jr,; 95,4P in E1011- Heating H In dry a1c. Ila gave Ila mnd H,
VCjjjC04YjjCjj,C(hFJJ1(7 (IV)
in. 11W. Ileating 11
.,
N
-11 hk. r -e M% 11 and t6NAc. and
g:%v ,
-diml
si, ,1 11 with OAX fICI
kith A,
ave 1
11
are
O
diazopip---azine (11a) reamd 3 ]`-rs. in.EtOTT gave It. .
y
,
g
3
g
Ik and IV, it the reaction is ruiv iti dry 1i!011; ate. NmOif
dtid 2-C,,] LNLf~jhjEt.Q gave .7z ~11;6' Itk13 d j~ re* -arid It gives 111. G. Nf. KoWarxyrt
USSR/Chemistry - Biochemistry
Card 1/1 : Pub. 129-10/25
Author : Mwarov,, K. S. ad GaVrILM, N. 1.
Title Electropboresiso electroreductloup and spectrophvtomstry of plastelas
reriodical fest. Nbsk. un. Ser. f1sibamet. I yest. nauk,, Vol 10, &-N, Tab 1955
Abstract Showed by electrophoretle dlagMms that plastein Is not a f raction Of
casein. Conducted electrophorstle analysis of plastein obtained from
human serum albumin hydro3,yzate as prepared by enzym hydrolysis. The
plastein thus obtained differs from the plastein from casein ih amino
acid nitrogen content. Also prepared copper complexes of the plasteins
and analysed then electrophoratIcally. Studied the electrophoresis of
casein electroreduction. Tabies~ diagram. Fovrteen references
(twelve USSR).
Institution Chair of Organic Cheodst,17
Submitted Jun 26, 1954
L-0 V
USSR/Organic Chemistry - Naturally Occurring SuIbstances and Their Synthetic
Analogej, B-3
Abet Journal: Referat zhur - MLtmUz,, No 19, 1956,, 61681
Author: Gavrilov., N. I... Ioanistani., P. G.
Institution: -Xwe
Aft. as On the Amount of ay Iclic at-fine Bonds of Amino Acids in S(ne
Protolm
Original
PoVdicals Zh. dbahch. 25V No 9,, 1802-1812
Abstract: cridictice (MR) of derivatives of diketopiperazines (DP)
On electri
-
reactions occur: - in tbe~caee of aminoacyl-Dp t are formed
p~peraz*s of peptides; In the case of amidine d Vives of DP
ER is accaqwied by formation of free piperazines and a splittlM
off of peptIdes terminal amino group of which can be determined
by the gasometric method. - ER was carried out at a movable mercury
electrode Opcording'to the method of Gsvrilov and Koperine, (Zh.
obahch. kh-1-4i., 19kTsI17, 955p 1651). Changes in procedure involve
Card V3
- -- - - 63-~)
14.4
jo VI 13-9 (16
1)
R
.
.
eaWtively, I of DP in
found to be 27.6; 46 % Of total N rre
8
1
; 3
-03) 30.9; 23.1 and 40.o. procedures
used for the analysi, -
, of
`
Ub~~ hYdrOlYBates before and
were
h
c
after im
ecked with an art
ffic
ial m'
*We Of amino acid. correspond-
iDg to the composition
Of Ill. Folffol t'tration 'With the
Card 2/3 use or