JPRS ID: 9710 WEST EUROPE REPORT

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APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFI('IAI. USE nNLY - JPRS L/9956 , 3 September 1981 _ Ja an Re ort p p (F4U0 52/81) FBIS FOREIGN BROADCAST INFORMATION SERVICE FOR OFFIC[AL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R440400050006-6 NOTE . JPRS publications contain information primarily from foreign newspapers, periodicals and books, but also ~rom news agency transmissions and broadcasts. M,aterials from foreign-language - sources are translated; those from English-language sources are transcribed or reprinted, with the original phrasing and other characteristics retained. Headlines, editorial reports, and matPrial enclosed in brackets are supplied by JPRS. Processing indicators such as [TextJ or [Excerpt] in the first line of each item, or following the last line of a brief, indicate how the original information was processed. L~lhere no processing indicator is given, the infor- mation was summarized or extracted. Unfamiliar names rendered phonetically or transliterated are er.closed in parentheses. Words or names preceded by a ques- ti~n mark and enclosed in parentheses were not clear in the original but have been supplied as appropriate in context. Other unattributed parenthetical notes within the body of an - item originate with the source. Times within items are as given by source. The contents of this publication in no way represent the poli- cies, views or atritudes of the U.S. Government. COPYRIGHT LAWS AND REGULATIONS GOVERNING OWNERSHIP OF MATERIALS REPRODUCED HEREIN REQUIRE THAT DISSEMINATION OF THIS PUBLICATION BE RESTRICTED FOR OFFICIAL USE ONLY. APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-40850R040400054006-6 FOR OFFICIAL USE ONLY _ JPRS L/9956 - 3 September 198 - JAPAN REPORT (FOUO 52/81) _ CONTENTS SCIENCE /~uJ7 I'EQiNOLOGY Ibw Chemical's Strategy in Japan, Worldwide Analyzed (SHUKAN TOYO KEIZAI, 17 .Jan 81) - Finns Planning To Work With Biotechnology Surveyed (NIKKEI SANGYO SHII~LIN, 13 Jul 81) ~ ~ - a - [III - ASIA 1'~1 ~"OliJ] FOR OFF[CIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-40850R040400054006-6 SCIFNCE AND TECHNOLOGY llOW CHEI~tICAL'S STRATEGY IN JAPAN, WORLDWIDE ANALYZED Tokyo SHL'KAN TOYQ KEIZAI in Japanese 17 Jan 81 pp 88-98 (Text] Survival Plan for Sada and Vinyl Chloride A].though the f acade of the Japanese petrochemical industry appears unusually unpe~-- turbed by the aggressiveness of Che American Dow Chemical, an unbearable sense o- crisis constantly predominates behind the scenes. The Japanese petrochemical industry, built an a vulnerable raw material foundation, can b~ "wiped out unless some countermeasures are devised using this issue for momentum. The Dow activity is a warning bel~" (chairman Fukashi Hori, Asahi Dow). _ Activities among corporations and groups are being mobilized under the surface tc respond to the approaches made toward Japanese firms by Dow. If an operational tie-up and joint Cank construction take place, that will not only create a stir in the caustic soda industry but may even shake up the structure of the Japanese petro^_hemical industry. The strategy toward Japan dieclosed by Dow at the end of November last year included: 1) long-term mass import of ethyl~ne dichloride (EDC), vinyl chloride monomer. (VCM) and caustic soda; 2) construction of a tank base ~ointly with .]apanese firms to receive the imports, with a target partial operational date sec Lnr the end of 1982; 3) constr~ction of a VCM plant (annual production: 30,000 tor~s; operational in 4-5 years as a joint venture with Japanese firms at a cost L $l~~ mil.lion. Among these, the import o,: EnC and VCM and the construction of storage tanks pase an immediate problem to the related industries. The import ~f caustic soda is eatimated to be ~n a scale of 200,000 tons (dry base) in the ^~.{c 'L years, but the actual scale is likely to shrink considerably since the pro~~ct on , mu::t }�iF~1d to the demand. ~lso, a r.elated sou~ce calculates that the production of VCM in Japan "will be delayed at least 7-8 years even if the prcject is undertaken. They don't intend to start it now. It's only a trial balloc~n announcemenC." In the circumstances, the focal poinC is YIOLl Japanese firms respond to Dow's idea of constructing a Lan~. base which ca~ handle an annual dem~nd of 500,000 tons of EDC and 100,000 tons of VC;~t . 1 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R004400054006-6 - FOR OFFICIAI. USl~: ONLY Usin~; Fixation oF FDC Import as a Lever Ttie basic rPasons that Dow is aiming at the Japanese market are higher growth rate ot ~~CM and EDC' than in Europe and the expectation of demand for cost-competitive Dow products. Al.so, Dow is directing its aim at the moves toward structural renovation hy the caustic soda industry, which is presse~i by the second manufac- turing mettiod conversion due by the end of 1984, and the vinyl chloride industry which is also involved in it. Lncidentally, in 1.~79, EDC imports increased rapidly to 387,000 tons (double com- pared to the previous year). Althougti it is estimated that imports dropped to the ?evel of 210,OOU-220,000 tons last year, that figure is still above the 190,000 tons recorded in 1978, which represented a dramatic almost four-fold increase compared to the year before that. In the case oF 1978, tli~ increase in the demand for petrochemicals triggered a scran~ble for ethylene amung polyethylene makers and vinyl chloride makers. Al.so, the stringency in the supply of chlorine was forecast due t~ the low demand for caustic soda, which, according to the analysi::~; kindled the expansion of EDC impor.ts. Last year, these special conditions were eased and the demand for ethy- - lene was considerably reduced, but the EDC imports have continued at a relatively }iigh level. This is clearly attributable to the international competitive cost ciif.ferential of chlorine. It can be considered that these "pictures which indicate that EDC imports have taken root in 3apan encouraged T:ow's decision to launch an attack on the Japanese market" (executi_ve director Okubo of Toyo Soda Manufacturing). Incidentally, it is said that approximately half of.the EDC imports are Do�w products. f.,earning From Mistakes ,:~t one time Dow experienced difficulty in its attempt to venture into Japan. Dow initiated a strategic move toward Japan using the 1972 complete liberalization of capltal tr.ansactions for caustic soda and chlorine enterprises as momentum. In 1.976, Dow obtai.ned permission to manufac.ture causCic soda, and it also started import s~les, snowballing its activities which reached a peak with the launching of a bi~ plan to build a caustic soda plant. However, the plant site selected had to be changed from eastern Tomakomai to Sodegaura in Ch.iba, Tachibana Bay in Tokushima and to Hario in Nagasaki due to opposition by the local communities. The scheme for advancement was after all cancelled. This failure to advance reflects a background of fanatic opposition by caustic soda firms, which had been weakened with the burden of the first manu- Cacturing method conversion, and the strong opposition of the local commurities toyal to the ].ocal caustic soda ~.ndustry. rteanwhile, ir is also said that Dow had second thoughts about starting an electro- lytic enterprise in .lapan, where the energy cost was high. Learning from these f.ailures, since then Dow has steadily worked earnestly if not spectacularly in lapan. Already, Dow supplies 7 percent of the chlorine derivativ~. ~~roducts used in Japan, which is equivalent to 60 percent of the chlorine derivative 2. FOR OFF[CIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400054446-6 ~mports. Also, it has a Product Development and Research Institute (establish2d in 1976) in Cotemba, and a polyole plant using urethane foa~ as the raw material is also under construction, with operation scheduled for this year, 1981. The move taken by Dow at this time "is supported b;~ the adequately strengthened relationship with related companies and by homework well done on the business world and market structure in Japan", commented a related source. In addition, this time there are firms in Japan--for instance, Mitsui Toatsu Chemicals--which are examining Dow's proposal. In short, in the Japanese business world, there appears to he a change of mood in that the satisfaction of hunger precedes other matters, even if it means that Japanese companies must ~oin hands with "notorious Dow," which devoured European markets by aggressive low pricing. Mitsu Toatsu's t~pproach to Dow At the moment, Mitsui Toatsu is making stealthy moves regarding association with Dow. Last year, concernea personnel went to Hong Kong where the Dow Pacific head�- quarters is located, and made an agreement to draw up an original plan between the two companies very soon in Haw~ii. Mitsui Toatsu took Dow executives to the Isumikita plant for a tour, demonstrating a positive attitude toward EDC imparts and investigation of joint tank construction. However, Dow has not clarified its intention as to whether Mitsui Toatss can serve - as Japa:i's window with the right to represent Dow or if it is to be treated merely as "one of several" upon organizing an import-sales fircn. That is, discussions between the two companies have not reached a decision concerning the form of the new firm--a consortivm or the use of Mitsui Toatsu as a sele partner with the right to represent Dow, ae far as the Japanese side is concerned. A source close to this deal in Mitsu~ ~:,atsu put it in pers�pective: "It may well take the form of polygamy. Although it depends upon the volume of transactions, that form might help us to alleviate the riek of totally depending on Dow." In such a case, the new firm might even be on a near commercial basis. 'I'he name of Mitaui Toatsu is said to have been initially used in a release dis- tributed at a press conference held ~y Dow. However, Toatsu arranged to have it altered to the phrase, "construction of tanks jointly with Japanese firms...." The alteration, a related source pointed out, is evidence that the relationship bet~eeen Dow and Mitsui Toatsu irs consolidating at a rapid pace. Meanwhile, another related source expressed the opinion: "The relationship bettween Dow and Toatsu does not ap~ear to be progressing as fast as the Dow side wants it to appear." - i.t is suspected that Dow hae also felt the pulaes of all vinyl chloride makers in addition to Mitaui Toatsu, such as the Shin-Etsu.Chemical Industry. This leaves room for speculation that Dow might tie up with a f~rm other than Mitsui Toatsu or with multiple firms. One source considers that the Oita Center of Showa Denko, which can offer tank base grounda as well as users in its proximity, is the best contender, although it is not a vinyl chloride maker. 3 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFICIAL USF. ONLY - The Japanese side, as seen in Mitsui Toatsu, is obviously inve~tigating Dow's offer, because the structural problem of Japan's vinyl chloride industry and the problem of the second caustic soda manufacturing method conversion are intertwined. Vinyl Chloride Industry Renovation Plan To Be Tacked On The vinyl chloride industry led by the Vinyl Chloride Industry Association charted a structural renovation plan during the prev~ous antideFression cartel period (May 1977 to August 1978). Hawever, three companies--Toyo Soda, Nissan Vinyl Chloride .(a productian subsidiary of Nissan Chemical Industries) .:nd Tokuyama Sekisui-- announced their intention not 4:o participate in this structural renovation plan. Ldhile the Vinyl Chloride Industry Association continued to urge the three to change their mind, demand was renewed and so the structural renovation plan was shelved. This industry has encountered a downpour of depression since the spring of last year after the boom of 1979. It looks like it ia constitutionally predispose~ to "suffer from the progress of a malignant illness after recovering from one sick- ness" (executiv~ director Fukae of the Kureha Ch~miCal In~iustry). The vinyl chloride industry traditionally maintains exce~sive equipment and peren- nially maintains a priee war which can be criticized as being excessively competi- tive. In particular, the confrontation between the vinyl chloride monomer group and the polymer groups is fierce. Furthermore, the heavy burden of the manufac- turing method convPrsion is an extra drag on the industry since many firms have branched into the field of soda and chlorine electrolysis. ~ In the circumstances, the companies may agree in general with the theory of scrap- ping equipment, but the realization of the idea at each step of the theory will be difficult in view of the growing conflict among them. Recently, Mitsubishi ~Ionsanto Chemical of the Mitsubishi group suspended production of VCM (annual production 80,000 tons) and caustic. soda (annual production 200,000. tons) at the Yokkaichi plant, and decided to aubcontract and concentrate production at the Mizushima plant of Ryobi. They signed a sales contract for Mi~tsubishi Monsanto to sell polyvinyl chloride (PVC) to Ryobi starting in 1978, but. their tie-up advanced one step further to the intensive production of V~'M. This deal was made rather smoothly to concentrate the operation within the Mitsubishi Chemical Industries group. Even amoa~g different business gro~ips, three companies-- Asahi Glass, Kureha Chemical Industry and Shin-Etsu Chemical Industry--have affiliated operations extending over vinyl chloride and soda. This agreement is built upon the tie-ups between Asahi Glass and Kureha Chemical Industry and between Asahi Glass and Shin-Etsu Chemical Industry. As a result, Kureha Chemical Industry suspended the annual 100,000 ton crude oil cracking operation in the VCM installa- tions at the Niahiki plant, which suffered from the surging energy costs. Similar to the Kureha Chemical Industry, the VCM installation at the Takaoka plant of Japanese Geon, the original process of which became unprofitable after the oil shocks, was closed down in June 1979. This move increased the operational ratio of Ryobi and Sunarrow and was also connected to Che EDC imports from Dow. In spite of these partial ad~ustmenta, the present state of ttie total picture of structural renovation, including scrapping of equipment, is very slow and frus- trating. ,4~ FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 Shackled by Soda Manufacturing Method Conversion The structural renovation of the vinyl chloride industry is closely related to the caustic soda manufacturing method conversion. Caustic soda production capacity is 4.46 million tons per year (of which 1.65 million tons, or 37 percent, is made by ; the mercury method). Only the Noboribetsu mercury method installation scrapping - plan of Hokkaido Soda distinguished itself, along with that of Nippon Carbide Industries, during the second msnufactur..ing method conversion drive (to the ion- exchange membrane method in FY-80). Asahi Chemical Industry, Asahi Glass and ~ Tokuyama Soda, which have their own technology, an ion-exchange membrane method, are expected to convert the remaining mercury method~installations in 1981-82, earlier than the designated end o~ 1984 deadline. However, the remaining ffiajority of firms so far have given no signs of starting to change the existing installations until the very end ef the deadline. In some cases, howe~er, the possibility exists that some makers will get ambitious enough to scrap a11 or part of the remaining mercury method installations. This passive attitude reflects the heavy pressure of the cost of converting to the ion- exchange membrane method, the unpromising outlook in demand for soda even after the conversion, and the question of the cost competitiveness of the vinyl chloride, including the concurrently produced chlorine, in the case of the makers which also produce vinyl chloride. Dow is charting its current strategy toward Japan as follows: "Japan's chlor-alkali industry ie in a whirlpool of struct~:ral reorganization, such as closing of plants or the closing of ins~allations in stage~. Dow will fill the supply and demand gap created as a result of this reorganization" (president A. J. Butler of Dow Pacific). At the same time: "We will provide a long-term stable supply to meet the demand of the customers" (Butler). Dow's pronouncement, no matter how softly it is expressed, is a written challenge to the Japanese industries, which are suffering from the caustic soda manufacturing method conversion and the structural renovation of the vinyl chloride operation. Mitsui Group's Possible Reorganization '1'he necessity of concentrating vinyl chloride manufacture in the Nagoya and Izumikita plants has been talked about for a long time at Mitsui Toatsu, which is trying to approach Dow. Ethylene at the Nagoya plant is transported from Osaka Petroleum Chemicals (OPC), and is relatively expensive. In caustic soda operations, Osaka is limited Co the mercury method and Nagoya is limited to the membrane method. The cost will rise if Asaka's manufacturing method is converted. Therefore, the plan to purchase EDC from Dow ia credible. - However, if EDC is purchased, a large bottleneck will be created for OPC to consume ethylene, since the company doea not maintain a polyethylene operation but manu- factures ethylene of high specific gravity for vinyl chloride use. There is every indication that the plan to concentrate the vinyl chloride produc- tion by the Mitsui group, such as Toa Gosei Chemical Industry, Electrochemical Industry which is semi-Mitsui group, and Kanagafuchi Chemical Industry, may have been triggered by the Dow EDC import plan. However, there has been no sign of actions by Mitsui Toatsu to influence others in this direction. 5� FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFI('IAL USN: ONLY i~evertheless, Electrochemical Industry is quite volitive: "It is very risky to join hands with Dow, but the vinyl chloride ~nterprises of toa~orrow will seek a way to obtain inexpensive raw material's. We will be very interested if Mitsui asks us to join in the sch~me to institute a EDC import company" (vice president Shinohara). Kanegafuchi Chemical Industry remains cool and is merely observing the situation. Its EDC imparte from Dow were the top-ranking in Japan in terms of transactions by yen until 2 years ago, including production on consignment for Korea. It buys ethylene from OPC. It might affect OPC's ethylene consumption, but it would be geographically advantageous for this company to decide to act in concert with Mitsui Toatsu. If Dow and Miteui Toatsu happen to head for a consortium, participation by Electro- chemical Industry and Kanegafuchi Chewical Industry remain possible. Related sources comment on the establishment of such a coasortium: "It would hold a quantitative bargainin$ power. If only one compar.y participated, it would be criticized to the effect that the combine (complex) structure would be destroyed." One thing that attracts attention in connection with the caustic soda manufacturing method conversion is the Kajima complex. In this area, Vinyl Chloride Monomer (capital invested 50 percent by Shin-Etsu Chemical Industry, ~5.percent by Mitsubishi Petrochemical, 10 percent by Asahi Glass, 10 percent by Kan~gafuchi and 5 percent by Asahi Denka Kogyo) proudly produces vinyl chloride monomer on the largest scale in Japan, accounting for an annual production of 270,000 tons. Chlorine is supplied by Ka~ima Electrolysis (capital invested 25 perc~nt by Asahi Glass, 23 percent by Shin-Etsu, 23 percent by Asahi Denka, 21 percent by Mitsubishi Petrochemical and 8 percent by Kanpgafuchi). Incidentally, Ka~ima Electrolysis is equipped with Japan's most advanced large mercury method installation. It hasn't been converted yet at all. The burden of conversion will be enormous. If by any chance it ia ~crapped instead of converted, the adverae effect that will fall upon firms which totally depend on Kajima Elec- trolysis for chlorine, such as Asahi Denka, will be immeasurable. With this in mind, it is very difficult for Ka~ima Electrolysis to make a fast move. Some calculate the possibility for the Ka~ima complE~x to serve as an import base for pow's producta ~udging from the geographical location. However, this is generally considered uniikely to take place in view of the presence of Asahi Glass, which has developed a new ion-exchange membrane technology. Likewise, the poeition of previously described Ryobi, which has. concentrated pro- duction within the Mitsubishi Chemical Industries group, is also delicate. This company supplies VCM to Japaneae Geon (Takaoka) and iCanegafuchi ChE~mical (Takasago and Osaka). If these two companiea start to show same move associared with Dow, it will affect the caustic soda manufacturing method conversion by Ryobi. The ratio of the installations of thia company not converted is 42 percent. There are more soft elements still remaining in the relationship between Dow's aggressiveness and the Japanese side, which is countering it. Nevertheless, "going against the current of the time does not work for Japan's petrochemical industry" (director Kenichi Watanabe of Showa Denko). A black ship named Dow may become the firat blast pressing Japan's chemical market to open up its gates in earnest. 6 ?L USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00854R000440050006-6 NOR OFF'1('IAL l)SN: l)NI.Y rigure 1. Placement of Vinyl Chloride Mono~ner and Vinyl Chloride Polymer Installations (production capacity 1,000 t/year) q*~i: I I� P H P!yY 3 71 M~~~~~~ i27. ~ a ~4 iu.s � M tll~E/'v-Ej i~ _ M =4F~~ � $ ~ . {dw . P ~~kt+*i�~ 77 41 P � ~A 27.5 ' P 7i7t7-1t* 82 ~tU~~lc ~ � P !!![it# � s9.5 ' 7Y70-1t 114 � ' M J2 M ~ll1/~ I.Z 200 � ~t~t3t.~ in . f� M~~Tt~ � t~25 i o.s ~ P !![~t~ � :!l111 59 , / 1~ P Aa1t* ~ . RMit~R 2 190.5 � , M t~11~~/v- 270- ~ F 58.5 ~ i� � M s~~~�~~ ~ ~~it~ . P'~i% SI . ~ ~tit~t�s~a~ u.s . ~ t~~tr* 34 : ss ~~Ir~ ~3 ~ ~ P~'It+l~ �~liit i i fi~~t~~ i~- iso 6 _ n~~ roe f~~.7 ~o.s 7 � M 290 M 9~it~ 60 8 8~1te--,~ eo 9 - : M it~tn*. ~ y c e o c) , - JII 14 0 � M t�Y %�~Ic* t9.5 P 1111R~ ~O � 1 19~ ~3.s M t.r~~wt~ eo 2 , Note: P for polyvinyl chloride, M for vinyl chloride monomer Icey : 1. Mizuahima 22. Japanese Geon-Takaoka 'l. Japanese Geon 23. Asahi Glass-Satauki 3. Chisso 24. Electrochemical-Ome 4. Ryobi 25. Kureha Chemical-Nishiki 5. Ryobi 26. Electrochemical-Shibukawa 6. Sanyo Monomer 27. Ka~ima 7. Tokuyama, Nanyo 28. Kanegafuchi Chemical 8. Shin-Etsu Chemlcal 29. Shin-Etsu Chemical 9. Sunarrow Chemical 30. Ka~ima Vinyl Chloride Monomer - 10. Tokuyama Sekisui 31. Chiba 11. Sunarrow Chemical 32. Electrocheanical 12. Tokuyama Soda 33. Chisao 1:3. 'foyo Soda 34. Sumitomo Chemical 14. Mitsui Toateu-Izumikita 35. Nisean Kagaku L5. Toa Gos~i-Tikuehima 36. Chiba Vinyl Chloride~Monomer 16. Kaneg~fuchi Chemical-Setteu 37. Asahi Penn Chemical l7. Knnegafuchi Chemical-Takasago 38. Niaean Chemical 18. Sumitomo Chemical-Niihama 39. Japan Vinyl Chloride (EDC) 19. Ctiiseo-Mizumata 40. Kawasaki 2U. 'l'oyo Soda-Yokkaichi 41. Kawasaki Yuki 21. M.Ctsui Toatau-Nagoya 42. Central Chemical 1 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400054446-6 1~()R ()I~N'I('IA1, IItiN: ()NI.Y Last Moment of Complex Era In Alberta, Canada, where Dow is planning to place a supply station for EDC and vinyl chloride monumer to be shipped to Japan, a gigantic petrochemical complex is b~:ing built. As a first-stage project, an installation that produces 540,000 tons of ethylene a year has been operating since September 1977 in the hands of local capital, Alberta Gas Ethylene. Dow takes all of the ethylene produced and manufactures 200,000 tons of vinyl chloride monomer there. And 450,000-ton class installations are being ne.wly con- structed for EDC, soda, chlorine and EO-EG. A 3,000-km pipeline has been laid between Fort Saskatchewan, where the plant is located, and the Dow Sarnia plant in Ontario so that the remaining 180,000 tons of ethylene can be used as a raw material. Products from this Sarnia plant will be shipped to the gulf coast on the east coast _ of the United Statea, which is truly a mecca for petrochemistry. An average 10 percent duty is applied to exports to the United States, so the cost competitive- ness is not necessarily good. The key products are derivatives which will be transported by rail from Fort Saskatchewan to Vancouver. This stretch is only half the distance to the Sarnia plant. Fort Saskatchewan has bountiful natural gas and rock salt, and electricity is also inexpensive. Products costing less than 100 y~n (around 170 yen in Japan at present) per kilogram, on the basis of the ethylene price, arrive in Vancouver. Commodity circulation bases such as EDC tanks and ships for exclusive usE have been already constructed in Vancouver. Since only some 20 percent of the national demand exists on the west coast of the United States, they were certainly placed there to aim at the Southeast Asian markets. EG and the like have already arrived in Japan. The second-stage and third-stage projects are being formulated in Alberta with the target operational date set at 1984 and 1986 respectively. The total ethylene up to the third stage will be on the 1.8-million-ton ecale. As ethylene derivatives of the second-stage pro~ect, intermediate and low preasure polyethylene of Dupont, styrene monomer of Exxon or Shell and LLDPE (a third kind of polyethylene) of Dow are named as candidates. The total Canadian ethylene and polyethylene production will be 3.5 million tons and 1.7 million tons (currently 60Q,000 tons) reapectively in 1990, and some pre- dict that two-thir.ds of the prcducts will be exported. Repositioning of Pacific Sphere These positive activities in Canada are very characteristic of.the future petro- chemical development. In the United States, raw mate?-ial costs will be 30-40 per- cent cheaper than in Japan and Europe due to the domes!:ic price control over crude oil and natural gas. T'nis price control is expected to be lifted (decantrolled) in September 1981 for crude oil and in 1985 for natural gas. After the decontrol, it is obvious thaC the competitiveness of American products will be lowered. - 8 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 Also, in the United States, oil c:apita~ often enters into the petrochemical business. The present shares of each petrochemica~. product held by the oil company group in the United States are 60 percent in ethylene, slightly less than 90 percent in benzene, 60 percent in polypropylene and 40 percent in polyethylene. These shares Fertain to either refined products or primary reactio-~ products. With fuel consumption regulation over passenger vehicles, gasoline demand is expected - to drop. The oil companies are aggressively looking for a new source of profit in petrochemistry. The weight is, so to speak, shifting from conventional petro- "chemistry" to "petro"chemistry. Adding to the forecast decline of the raw material advantage in the United States, competition between oil and chemical capital has opened an overseas rush to seek resources. Furthermore, im~estment in advanced areas--Canada, Alaska and Australia--is in the limelight. These areas a11 belong to the Pacific sphere. The repositioning of outposts in this sphere that involves the Japanese pttrochemical industry is shaping up. Absolute Advantage of Resource Holders ~ In the past, the world's petrochemistry was established in Japan, the United States and Western Europe where gigantic demand existed, and was developed by each supply- ing i.ts own market. The annual demand for ethylene in each area is 4.2 million tons in Japan, 13 million tons in the United States (estimated) and 12 m.illion tons (estimated) in Western Europe. Southeast Asia, flanked by the~e areas, currently shows a very small demand, 200,000 tons (estimated), although it has a potential growth capacity. Southeast Asia is relegated ta being an export market of Japan, the United States and Europe. In the past, basically only the excess aupply of each area was put out for export, a pattsrn where domestic demand had priority and the surplus was ~xported. The basis for these mar~Cet location type tripolar structuxes was that they could secure inexpensive raw materials and en~oy the benefit of large-scale investment. However, midwifed by the two ~il shocks, the absolute advantage of the rpsource holder revealed itself at last when 80 percent of the total cost of universal chemi- cal products was claimed by raw material costs. Among the tripoles, the petro- c:hemical industry of the TJnited States is blessed with the optimal condition of _ having the market location as well as the resource location, and it retains out- standing competitive power. Un the other hand, the Japanese petrochemical industry's international competitive- ness rapidly declined. 1. 1975, after the first oil shock, domestic demand dropped drastically, and the surplus, mainly the universal use resins such as polyethylene, was placed for export. I~ a3dition, im~orts dropped drastically (see Table 2). `I`his happened at a time when the price of domestic products was relatively expen- sive, 1,OQ0-2,000 yen per kiloliter, compared to the imported naphtha, because the price of raw material naphtY:s was still on the rise i~n 1975-76. 9 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPR~VED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 I~()I2 ()1~1~1('i;ll, litil~: ()NI.Y 1'able l. Cont�nuous Depression of Exports (unit: 1,000 tons, . _ 2 3 4 5 ~ � --n-... . ~ _ ~ ~o i ss u 8 : s ~ . ~ ns ~s ~~r ~u aw sia (19.!) (31.9) (25.5) (29.8) (23.9) (14.1) (24.9) 9~:nyQe~. 100 154 116 14Z 161 ~ 98 '48 (2Y.6) (25.9) (17.2) (23.3) (21.6) ~9.6) f6.1) 10 e~~! 147 131 119 90 54 ~ 82 48 ~ (30.0? (11.?) (11.4) (8.8) �(4.4) (5.2) (4.0) 11 tt e=~ ~ P- 64 117 166 i81 250 105 . (5.D) (9.0) (12.41 (12.1) (8.1) (7.4) 12 Y;i: 9 x# u i. 69 69 ' 81 ~ 88 98 90 6~ (S.1) (5.8) (7.0) (9.8) (9.4) (7.3) (12.3) 13 aX}~,~/v- 98 73 b8 40 41 18 2 (D.5) (8.9) (5.S) f8.9) (3.8) (1.3) (0.3) B T X'{0~ 4~? 2Z9 300 381 'J41 3d0 ~10.1) (T.4) (5:8) (7.4) (9.2) (7.8) (10.3) E G - 10� 20Y 42~ 147 71 (45.8) ~38.8) .(95.0) (~.BI (18.SI 14 aa~~aio~l~te~#~tit, c ) v~i:~~tr_xtttM~s~ 15 ttUrh) ~e*1[~AMt~, ~1t~s~~tttA1R, +~SfM~t ~ Key: 1. 1974 11. vinyl chloride monomer 2. 1975 12. polyst:yrene 3. 1976 13. styrene monomer 4. .977 14. (Note) Actual val~e gained up to October for 5. 978 1980, figures in are export ratio to 6. .~979 production. 7. 1980 15. (Source) Prepared from NIHON BOEKI GEPPO by 8. polyethylene the Ministry of Finance and KAGAKU KOGYO 9. polyprolylene TOKEI GEPPO of the Ministry of International 10. vinyl chloride resin Trade and Industry Table 2. Basically Increasing Imports (units ~,000 tons) qa , i 1 18 E D`C l~f ' f!O 6! 3Yi 3/a 177' 9 ne n ~tt ~ y u ~ 4 ~ a~ u 10 X~'~Y~/~~` b o ia ia ~ e~ es 11 ~s~-w~l~ ia ~ i~ sa s~ a- ~ s r x a� i~a ev iae ieo ~ s~ a. ~e o a. ~ s~ s~ ee 12 Tf9saE~1~ - 6 7 0 ~ 90 6A 13 7 A ie u as 4a fik) 66~Ff3101li~C~~IR~ (tll~IF)~~t~B~kf�1lla~ 14� 15 Key: l. 1974 9. polystyrene - 2. 1975 10. styrene monomer 3. 1976 11. phenol resin 4. 1977 12. acrylonitrile 5. 1978 13. synthetic rubber 6. 1979 14. (Note) Actual value gained up to October for 1980 7. 1980 15. (Source) NIHON BOEKI GEPPO by Ministry of Finance - 8. polyethylene lA FOR OFF[CIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-44850R000400050006-6 N LY Ir contrast, this time, the surplus cannot be turned to export. Yet, imports are iiicreasing noticeably in the sector of bulk products. It is natural that exports di~opped in 1979, when there was nothing left to export because of the stringent supply of raw material and the favorable domestic demand. However, exports did not recover even ~hen the domestic demand fell in reaction in 1980. This is be- cause European products were the only competitors to Japanese products in the export' market encirc~ing Southeast Asia during the previous recession, while at present overwhelmingly cost-competitive American products have made a conquest of the mar- ket. For example, some vinyl chloride resin products on the market are even cheaper than the price of Japaneae ethylene. . Others Besides EDC Await an Opportunity to Flow In The American petrochemical indu~try had a small exportable surplus in the past, showing an export ratio of an average 10 percent, siihilar to Japan. The drop in automobile production and the housing slump gave a devastating blow to this indus- try in the United States, wliich prim$rily caused the universal use resin business to tumble down from the second quarter of laet year. The drop in demand hit bottom, but the recovery is painatakingly slow. These stagnant buainess conditiona are one of the factors preseuring exports. The fact thaz there are other factora makes the root of the trouble deeper. No new ethylene inetallation pro~ects are called for after 1982 in the United States. In this reapect, it can be said that no installations will be built for ex~ort pur- poses. - However, this is true oniy within the boundary of the United States. Overseas investment, which is expected to continue in the months to come, cannot be con- sidered without constant exporte. The current export aggressiveness may convey by and large an impression of preeale. "The queation of EDC �rom Dow raised at this time will not be limited to this item. Any products carried in bulk will be built into a long-term strategy," is the frequent serious reaction (director Kenichi Watanabe of Showa Denko). Indeed, looking at Table 2, EDC imports dxopped in 1980 compared to the previous year, when the shortage o� chlorine and ethylene dramatically accelerated EDC imports, but styrene monomer, ~G and acrylonitrile imports showed an upward trend. Vulnerability of Japanese Industries ~ If export aggreasiveness in Japan and Southeast Asia intensifies, Japan, to counter thie, can also scheme to obtain overseas locations for pursuit of inexpensive resources. This is a reasanable theory. However, the Japanese petrochemical induatry unfortunataly does not have enough real power to assume the role of an advantageoua reeourca holder. In Singapore, a 300,000-ton ethylene operation, palyethylene, polypropylene and EO-EG operations are expected to be initiated in the fall of 1981 under the leader- ship of Sumitomo Chemicals. This is not a raw material location, but an oil refinery base. It is certain that the coet competitiveness will be low. Also, the securing of marketa ma.y encounter difficulty since the project was not approved by ASEAN. In addition, the more etringent pollution control may affect the project. . l,l FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007102109: CIA-RDP82-00850R000400050006-6 FOR OFFIC'IA[. l1SF UN1.Y Meanwhile, Saudi Petrochemical is located in a nation which has resources but which suffers from political instability. It is often considered that normal operation will meet with difficulty from the aspect of technical transfer. "If a large _ deficiency does not appear, we must celebrate, under this system which gives priority to national interests" (a related sourc~). The co;apany is relieved to be able to scale down to 500,000 tons of ethylene following a~oint operation agree- ment with Dow. With the example of Mitsui's failure in Iran adde3 to the uneasiness, the purpose: of opening busineases in the developing nations, alChough they may have resources~, is fading away in the petrochemical industry. In Iran Petrochemical, there was a~ plan to bring EDC to Japan. The facr that Mitsui Toatsu is whetting its appetite: to purchase EDC from Dow may be one of the indications that the Iran route has been virtually "given up". This aesumption is further supported by the [~ustra.li~i Redcliff Pro~ect anaounced by Mitsui Toatau with Asahi Chemical Industry. "Economically, Canada is preferable, but Redcliff also has natural gas. It may even have oil; we cannot be ab~olutely suree We might even be able to obtain the~ right to hold reaources," is the explanation of the advancement plan (Mitsui Toatsu). However, preceding this, there w~s the episode of Mitsubishi Chemical Industries and Mitsubishi Corporation implementin~ a feasibility study. According to the results of the study reported at that time, "money will be consumed by stagflati~~n investment, and the natural gas will not even last 10 years." The fact that Dow was hesitant to start a feasibility study and lost the option may have been due ~to such circumstances. On the other hand, Mitsubishi Chemical Industries acquired the right to implement a feasibility study at Prudhoe Bay in Alaska "by following the trail of the Dow- Shell group." However, the problem there ie the ownerehip of natural gas. The assurance given by the atate government for ttae location was the aupply of natural gas held by the atate. But the state owne only one-eighth of the entire Prudhoe Bay natural ga~, and so it "can be worth only a 100,000-ton ethylene installation" (Mitsubishi Chemical Industriee director Hiroshi Watanabe). Dow is currently negotiating for the remaining seven-eighths of the natural gas with Exxon, which owae it. In aay case, the vote of Mitsubiahi Chemical Industries which has the right to hold resources ie not significant. Another example of a~oint venture is five companies--Mitsubishi Chemical Indus- tries, Mitaubiehi Petroch~mical~ Mitsubishi Corporation, American Occidental - Petroleum and Canadian Dotne Petroleum--which have agreed to promote a petrochemical - complex pro~ect that will produce 3009000 tons of ethylene, 100,000-150,000 tons of high pressure polyethylene and 300,000 tons of EDC in British Columbia, Canada. "We would like to handle this as carefully as we are handling the possibilities in Alaska" (Watanabe, Mitsubishi Chealical Industries). ]2 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400054006-6 F(l~R OFF'1('IAL U~E ONI.Y Are More Coming To Approach Japan' As described above, Japan's petrochemical industry is vulnerable in light of the fact that it does not have the advantage of being a resouxce holder. At the same time, Japan's petrochemical industry has not acquired a global market, and cannot graduate from the.practice which grew up during the daqs of the Japan-U.S.-Europe tripolar structure. The overseas sales ratio of American petrochemical f3rms has reached a high level, for instance 50 percent for pow, 40 percent for UCC and 30 percent for Dupont, whereas Japan's Mitsubishi Chemical Industries, Mitsui Toatsu, Showa Denko and Sumitomo Chemical all maintain only a 10 percent level. - As seen in Saudi Arabia and Singapore, Japanese petrochemical companies acquired capital power in the form of a consortium when they advanced overseas, and they often supplemented informatioa networka and selling power by the participation of trading catnpanies. Even with this preparation, the Japanese firms made good only in the Japaneoe tnaYket or the limited Southeast Asian market. If production activity is atarted in an oil-producing nation without a solid new marret, the products can be sold only in the existing m~rket. Overseas locations are associated with the problem of delivery of goods. American teams can easily take the defeneeless naked Asian market and are familiar with the ins and outs of the West European market, but they can get snarled up in the Japanese market. But if only there is a pilot, they can come in any time. Americans will not play a power game by setting up a damestic or foreign ~oint concern or a conaortium to sweep Japanese industries off Cheir feet, but will devisz a way to envelop Japan for a landing: . Japan's market is immense and has further potential growth compared to the American and European markete. It is posaible to coneu~ie the inflow to an extent. Never- - theless, the high growth rate of an annual 20 percent increase that Japan once enjoyed ie now beyond her dream. The market is large, but not enough for a living for ourselves and the incomexa" (Watanabe, Mitaubiehi Chemical Induatries). The American goods offensive led primarily by bulk products is, however, inevitable. Now we have plunged into the time when the Japanese petrochemical industries must set up an operational atrategy in proportion to this attack. And on the other hand, we must carefully avoid any policies tinged with protectionism such as an import narrier that wi11 impede a rati.onal conversion. ~ Collapaing Complex StrucCure From the starting point of the Japanese petrochemical industry in the decade from 1955 to 1965, it was necessary to establish a production system that used naphtha as a etarting raw material and collectively utilized propylene fraction, butane- butylene fraction and cracked' residues which were produced in connection with ethylene. Large-scale operations were sought to gain the economies of scale and comprehensive operations to utilize each fraction efficiently. ~3 FOR OFF[CIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFICIAL USE ONLY '1'o each complex, new industrialization of polypropylene and acrylonitr.ile and acetoaldehide manufacturing method conversions were implemented in the latter half of the decade. In addition, electrolysis equipment, ammonia and methanol were also incorporated into each petrochemical complex. The cost reduction achieved by these large-scale, comprehensive operations increased the demand for products to be used for automobiles, home appliances and synthetic fabrics and created a demand for products used as paper and iron substitutes. A happy cycle appeared when these expanded demands made larger scale operations pos- sible, recreating the increase in demand encouraged by the further cost reduction. ~ Since the first oil shock, however, the faults in the complex structure have been revealed by the integral effects of the unbalanced moves in demand. A further blow from an incre3se in foreign imports such as EDC could wipe out the balance of the integrated effective utilization of various continuously produced fractions that serve as the main pillar of the complex structure. Inevitable Reorganization . The 500,000 tons of EDC imports that Dow is talking about far surpass the production of a single complex. The largest EDC installation in Japan is Tokuyama Doda's 200,000-ton acale operation. Even adding the 180,000 tons of vinyl chloride monomer produced by Sunarrow, which ranks parallel with the Idemitsu Petrochemical and Tokuyama Complex, the total production is slightly over 400,000 tons in terms of EDC. And 400,000 tons of EDC is equivalent to 280,000 tons of chlorine and 120,000 tons of ethylene; this amounts to a large nart of the complex. This is true of acrylonitrile and EG. Even if the ethylene supply is greatly depleted, the products manufactured in connection with ethylene such as olefins may be still needed, which creates a large imbalance. Japan's petrochemistry must rely on foreign raw materials for crud.e, naphtha or intermediate raw materials. If naphtha which is customarily imported is replaced by an inCermediate raw material which is obtained lower on the production line than naphtha, materials in the atream above thia point will become unwanted. The industry ie pressed to cope with this from both sides--which product should be produced in order to be the moet rational (horizontal), which stage of the produc- tion system should the Japanese petrochemical induetry choose to start production (vertical). In Japan, where uaera are very critical of product quality, the inflow of monomers as intermediate raw materials may be acceptable, but polymer imports will not be readily received in the market. However, in the field of LLDPE, where competition for technologicgl development has intensified, rivalry for a share of the market is in evidence, including foreign technologies such as those of UCC and Dow. In Alberta, ventures by Asahi Chemical Industry with Dow technology or by Asahi Dow, a subsidiary shared 50-50 by the two companies, are being considered. Also, Nitto Chemical Industry auppliea acrylonitrile to the parent company, Mitsubishi Rayon, but Mitsubishi Rayon~ in a move going beyond the business affiliation, is substitu- ting inexpensive imports for part of the supplies. ~14 ~ FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 k'resident Hisashi Ki:rokawa of Mitsubishi Petrochemical says: "The second-stage - project of Kajima cannot be a c~py of the first stage." If this statement is applied to existing complexes, a reorganization and reconstruction of the com- plexes are perhaps inevitable. Intensified Dow Tactics to Grab Warld Market Shares Among the world chemical industries, Dow Chemical is well known as a firm which has most aggressively enforced multinational development. The weapon it uses for this development is not particularly special. Dow's approach clings to a very simple and crude theory that calls fur the mass production of universal goods at a bottom low cost and the expansion of markets. The main strength is the world's largest and most competitive chlorine products, specifically, vinyl chloride, sCyrene, and polyethylene. Furthermore, Dow's = business practice dictates that ic not get its hands into polypropylene at all, although it is a universal reain, and that it deal only with EDC and monomers, but not with polymers even among vinyl chlorides. To maintain competitive strength, Dow's conventional practice calls for locations advantageous from the aspects of raw m_.~erial, energy and~cost, and purauit of an all-out scale of mass production. In Pursuit of Natural Gas After the first oil shock, Dow sought plant locations advantageous in resources, on ~ne hand, and extended its areas beyond the traditional European and American cultural sphere, on the other hand, with outstanding developments in Asia, the Pacific and Central and South America, especially in unison with the rise of the moderately developed nations. - After the oil shocks, the world chemical industry entered into an era in which a serious question aroae regarding whether petrochemiatry is downstream of the oil industry or still in the genre of the chemical industry. In reality, the large equipment investment for petrochemistry in the latter half of the seventies was overwhelmingly made by the ma~or oil companies or crude oil holders such as the oil-producing nations, rather than by the purE:ly chemical firms. In the midst of this trend, Dow intensified its move toward u~~stream by attempting to counter the ma~or oil companies. It made a series of offe:nsives--resource exploration in Canada together with Dome Petroleum, expansior. af the service business of the dowel [phonetic] sector to the oil industries, holding of lignite deposits in Texas, and a crude oi1 refinery installation (180,000 barrels a day) in Oyster Creek, Texas. It also holds coal mining areas in Australia. This company is self-supporting in 80 percent of the electricity it uses, and holds more than 10 percent of the natural gas it uses from its origin. However, these strategies are powerless against the oil ma~ors, which formulated a scheme for control of the well spring of resources. It can be said that they are merely measures to maintain bargaining power. . l.5 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007102/09: CIA-RDP82-00850R004400050006-6 FOR UFFI('IAf, IIfiE ()NI.Y Figure 2. Worldwide Network of Dow Bases ~ it~~~ :~'?~9rr14~6~~! ,,D ~ ~ ~f~' .rY ~ i 1 ~ ~ . 2. ,~3 ~ 6 7 ~ . . M ~*13 . ~ ~ . 12 ~ + ~ ~ . 4 ~ ~ ~ w~'` . 5 , ~ ~ F~~17 16 . S!. ~i' ~ " ~ . � ' Y , , . . - � Key: l. Alaska 7. Holland 12. Saudi Arabia 2. Alberta, Canada 8. Germany 13. Japan 3. Midland, Michigan ~ 9. Yugoslavia 14. Korea 4. Colombia 10. Italy � 15. Hong Kong 5. Brazil 11. Spain 16. Australia 6. England A truly discreet approach is to bring a large plant to an area where inexpensive and plentiful resources are available. 'rhis idea was embodied by the ventures into Alberta, in Canada, the Alaska pro~ect, the Redcliff pro,ject in Australia, the Saudi p~o~ect and the projecC to advance into northern England and directly connect to the North Sea oilfields (liquefied natural.gas). It also still has a project for advancing into developing nations witti resources, such as Indonesia. c~C ~tiem all, the Alberta pro~ect was the first to be completed. In Canada, there I:: cilso the Sarnia plant, which was the company's first venture into a foreign country in 1946 and was built in a province ad~acent to Michigan (where the main of.fice of Dow is located, in Midland). This is the largest chemical plant in Canada, and it produces vinyl chloride, styrene and polyethylene. The large-scale operation of the recently built Fort Saskatchewan plant in Alberta will. make a pair with the Sarnia plant Chrough pipelines. 'l't~~ province of Alberta has shown interest in promoting second- and third-stage ~~rajects similar to the petrochemical enterprise to be completed in 1983 and 1986 respectively. It is said that Dow has already demonstrated a desire to get i.nvolved in the second-stage project. 16 ' FOR OFFICIAL USE ONLY ~ APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400054446-6 '['o Australi~, Saudi Arabia and the North Sea In addition, in Alaska, where somewhat of a boom has been evident in recent years, Doa went into business at the head of a large consortium and acquired rights to r.onduct a feasibility study of Prudh~e Bay on the Arctic coast. This consortium i.s made up of eight companies, including two key companies of the Dow-Shell combine, _ A~a.hi Dow, Mitsubishi Chemical Industries and Dupont, etc. According to the project, a pigeline will be installed vertically across Alaska from Prudhoe Bay to the Kenai Peninsula on the south coast. A gas separation plant, a 450,000-ton ethylene plant, a 200,000-300,000-ton class polyethylene plant and a 250,000-ton EG plant will be constructed by 1985. The total investment reportedly will excee~ $3 billion ($1.4 billion for the pipeline alone). This will be connected to Alberta and the American mainland ev~entually by pipeline, according to the blueprint. On the other hand, an oil refinery plant in Oyster Creek, Texas in the southern United S~_ates was~completed last apring. It is not only scheduled to supply naphtha to an e+:hylene plant (540,000 tons) which consumes 200,000 barrels a day and is newly bsilt in Louisiana, but also to establish a raw material fuel self-supporting system for factories scattered in the gulf area. Meanwhile, the company is trying to establish a self-supporting system by holding lignite for electric generation in Texas. The pursuit of resources has not been confined to North America. Although Dow's option in the Australian Redcliff pro~ect was revoked by the local state government last October due to a long delay in the project, since the latter half of the seven- ties, the project "will never be abando~4d. We definitely want to go ahead with it," says Dow. (vice president Lundeen). - ls~ri i0Q ~ 90 r ' i gp 70 ' Figure 3. Steady Expansion in the Seventies 60 - � 2 ~ Key: 50 1. 100 million dollars 2. sales ao 3. operational profit 30 20 - 3 ~o- ' 1910 Ti M 78 4 7 1 77 71 7~ ' Also, the Saudi pro~ect was recently pushed forward by a joint venture with Mitsubishi. This finally set Che course to begin serious investment in Saudi Arabia. Although the details have not yet been specified, it will certainly ;~.7 , EOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFICIAL USE ONLY be clecided to reduce the scale of the derivative products that the two companies Lake delivery of, in addition to 500,000 tons of e~hylene and 500,000 tons of EG they must share. Furthermore, the policy of the Saudi Government seems to stick to the principle of setting 30 percent of the total investment value as capital, of funding b0 percent by means of a 3 percent interest rate loan from the Saudi Government, and of procuring 10 percent through the market. In the $2 billion Mobil project in Yanbu, Mobil and SABIC (Saudi Basic Industry Corporation) pro- vides $300 million each, the government loaned $1.2 billion, and the market loan was $200 millio:~. In the $3 billion Shell pro~ect, Shell's investment share was allowed to be only $400 million. Dow and Mitsubishi appear to be investing dol- lars based upon these shares in investment. Based on this principle, 15 percent or less may be Dow's share, which matces it quite a low investment. For the Dow company, which is unusually highly dependent on loans among American firms, this pro~ect has considerable advantage considering the present high interest rates. Informed circles agree that Dow is panting to - obtain Saudi crude oi1, since it is forecast that securing crude oil for the refinery in Texas will encounter some difficulty. They say the original purpose of Dow's advance into Saudi Arabia was oil. Likewise, the eighties' greatest theme of resource pursuit activities is the move to obtain gas in the North Sea. Dow hae announced a petrochemical pro~ect in , Firth, Cromarty, in northern Scotland. It plans to build a gas separation facility and ethylene complex based upon a pipeline to be inatalled across land from a pipe- line which has already been laid in St Fergas (slightly to the south) on the British mainland. The pipeline will be installed by 1984-85, a 400,000-600,000-ton ethylene installation will be completed by 1986, and the ethane gas surplus will be supplied to Dow plants on the European Continent. However, ICI, BP Chemical and Shell Chemical, which conetitute the ma~or English chemical concerns, are showing strong oppos~tion. Sheer Snatching Tactics in Low Market Growth Meanwhile, Korea, Japan, Hong Kong, Brazil, Yugoslavia and Spain, which tend to have growing markets, are almost virgin soil for pow. Maneuvers to take some part of the market in these areas which have a high growth potential have been especially noticeable since the latter half of the seventies. In the Yosu complex, in Korea, a 240,000-ton soda plant, a 280,000-ton EDC plant and a 100,000-ton high pressure polyethylene plant were built and began operation in 1980. This complex, however, appears to be a big failure and ia suffering from a low rate af operation, directly affected by the drastic slowdown in the Korean economy. Meanwhile, Dow disclosed the intention to start a 360,000-ton soda (720,000 tons in the ~econd stage) and electrolysis base petrochemical chlorine complex around 1975. It looked for locations for a while, but in the end, as announced by vice president Lundeen at this time, it appeara that Dow settled on a policy of snatch- ing a share of the Japanese market through product imports rather than building plants. This can be interpreted as meaning that it does not make much sense to get involved in production in Japan, where raw materials, energy (especially elec- tricity) and cost are most expensive. 18 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 Figure 4. Increasing MultinationaZ Flavor, Toward Downstream (Unit: million dollars, . ~ Z5 7i~ Tl 7~ ?9 1 It ~ a.W s.16s ~,~31 k~a t~xi5 . T' r?1 il 56.7 54.4 55.5 52.9 49'.5 i~. 4~~'1c~Fl � 7~~) ~ 26.0 26.6 26. Y6.3 28.8 SAj ,~i t 6.6 6.5 6.4 6.4 6.8 ~ ~ 6 ~ ~ . ~ 3.7 4: a ~4.4 S.9 . 6.8' ~7 3fi7tUi~ , 4.8~ 4.L 4.4 4.9 5.I 8~7 3'> . 3.9 ~9.5 3.1 3.6 3.0 9 1~~~~~ 'J~ 13.~ .747 3,048 3,333 .~.535 ~,788 ' i~ � ~*~q~4 694 622 809 ' S43 578 r1 y'Jx#~'i~' 15 .r,~ �1.429 1.691 2,146 2, 479 3;458 ffi'~~ '~~1~6 301 392 3T3 ~ 414 693. j ~ ~ ~flb'i '~f17.~ 712 . 713 ?55 ' 8T4 .I,O1Z- - ) �~'1~~'1 '~~1 8 82 82 4~~ ' 94 63 ~ Key: 1. katio by areas 8. Brazil 13. Sales - 2. Total sales 9. Revenues by sector 14. Operational profit 3. America 10. Chemical products, 15. Sales 4. Europe, Africa metal products 16. Operational profit S. Canada 11. Plastics, packing maf~erials 17. Sales 6. Pacific area 12. Biochemical products, 18. Operational profit 7. Latin America conaumer goods Other than Korea, the relatively large plants built are a polystyrene plant of 70,000 tons a year in Hong Kot~g, and a plant of 15,000-ton scale in Thailand. As soon as the flong Kong plant wae completed in 1978, the exports to Hong Kong by the affiliated AsAhi Dow (50-50 investment by Dow and Aeahi Chemical Industry) showed a draetic decline. On the other hand, in Latin America, the Aratsu [phonetic] complex in Brazil was completed with the investment of $200 million, and in con3unction with this, Dow Brazil was aeparated from Dow Latin America to become an independent firm. Aratsu produces PG, P0, soda and chlorine group products, and is Dow's largest plant in Central and South America. ~ Worthy o� mention is the petrochemical businesa in Yugoslavia. This turned into a West-East ,joint oparation which is the largest in Eastern Europe. A complex for ethylene cracking and producCion of vinyl chloride, polyethylene and styrene on ~ Krk island will be completed in 1982-83. Already in 1978, a polystyrene plant in Zagreb started operation. The investment on Krk island will come to a total of $700 million. Recently, Dow opened a resident office in Peking, ana it is reported that Dow has concluded a long-term blanket agreement with the Republic of China. At any rate, Dow has steadily pursued resources and expanded markets with an insatiable appetite, but various sources point out that Dow's traditional business practice was about to encounter a eharp turn in the road. This was necessary due to the worldwide slackening of the growth rate of universal chemical products, the shrinking of areas available for market expansion, and the frequent labeling of petrochemicals as downstream products of the oil industry. . -19 . FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFI('IAI, 115H: ONI.Y I'u cumb.~t ttit~se trends, I)ow Ltself has decided to expand and replenish the bio- ~�h~�mic~l lield: it is rumored that it will expand tnto the gene engineering field ~~nd it wi:11 alsu purchase Richardson Merril, a large pharmaceutical company (it might very well end up in a joint concern or it might be a simple license purchase). tilso, various projects such as special resin, hollow fiber and coal liquefaction are being brought to light one after another. A popular direction from commodity - chemical to speciality has begun to be pursued even in a firm like Dow. Still, it is questionab le whether or not Dow, which has conducted business on the basis of mass production and mass sales, can successfully change its habits. Rather, it is more likely that the company will reinforce its accustomed business ~ractice of expanding its shares in generally stagnant markets using traditional products and approaches. In this sense, it seems correct to accept first vice president Lundeen's usual press interview in Japan as an announcement that Dov~ is serious about grabbing a share of the Japanese market. COPYRIGHT: Shukan ToyoKeizai 1981 8940 CSO: 8129/1451 . 2p. FOR OFFIC[AL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00854R000440050006-6 ; ; SCIENCE AND TECHNOLOGY _ FIRMS PLANNING TO WORK WITH BIOTECHNOLOGY SURVEYED 'rokyo NIKKEI SANGYO SHIMBUN in Japanese 13 Jul 81 pp 10-11 [Text] Biotechnology is being used for pharmaceuticals, chemicals, and food pro- ducts. Even trading companies and machinery manufacturers are getting seriously involved in biotechnology. According to a poll conducted by the Nihon Keizai : Shimbunsha, 95 companies, 72 percent of the 132 companies responding, were found to have specific business plans for biotechnology. It has been called the last technological revolution of this century. Zndustry has begun to put real effort into research and development for this indispensable and potent technology in order to create future business vitality. There are many different target dates for commercialization. Some companies expect to make use of the technology in 1 or 2 years; some have long-range targets of more than 10 years. This shows that biotechnology has already passed the "fever" stage and has been incorporated into business strategy. Commercialization for 47 Percent of Companies in 2 to 5 Years; Sights First Set on Pharmaceuticals Biotechnology will first be applied commercially to pharmaceuticals, next it will spread to chemicals and food products, and in the future it will move to the larger tields of energy and agriculture. This is roughly the commercialization strategy of the companies planning to work with biotechnology. 'Che 95 companies (86 manufacturers and 9 trading companies) which have business plans for biotechnology are aiming at quite different fields. Almost half--44 percent--are planning to apply it to pharmaceuticals, 23 percent to chemicals and food products, and 10 percent to energy. Also, many manufacturers gave specific names of products, such as interferon (virus propagation prevention gene), anti- biotic substances, and amino acids. From this we see that biotechnology is becom- ing firmly entrenched in the field of pharmaceuticals. Specialized manufacturers , such as Takeda Chemical Industries Ltd have always been involved, but companies in different businesses such as Suntory, Toray Industries, Mitsui Petrochemical, and Calpis Food Industry Company can be seen entering Che field. The new tech- ' nology is being used as a takeoff point for ventures into pharmaceutical and chemical products. Pharmaceuticals are the initial target because their high added value and growth potential make this a perfect market for commercialization of the new technology. 21 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFIC'IA1, ( ItiN: ONI.Y In Ltie period of low growth, the pharmaceutical industry maintained a growth of close to 10 percent and secured a high rate of profit. With this in view, compa- nies seeking to diversify find that "there is no business more attractive" (Suntory). 1'he target date for commercialization is 2 to 5 years from now for 47 percent of the companies. However, there are many businesses, like Showa Denko's amino acid manufacturing, which are already in operation. Also, there are many "reserve forces" ready for commercialization. Takeshi Tsuchikata, president of Sumitomo Chemical Industries, says: "We have roughly decided on pharmaceuticals, agri- chemicals, and petrochemicals. Now we have to narrow our sights." When it comes to energy and agriculture, commercialization wi71 occur later than in other fields. For example, Idemitsu Kosan will "require a least 10 years" to produce chemical products using gene recombination. Morinaga Confectionery "would like to improve seeds by cell fusion, but it will take 5 to 6 years to accomplish this." In agriculture, it is necessary to manipulate higher forms of Zife such as plant.s. In the fiel.d of energy, the price ~ompetition between crude oil and synthetic fuels is an important issue. The practical application of biotechnology will lead ;:o the expansion of peripheral markets such as machinery and plant construction. The large shipbuilders such as Mitsui Shipbuilding and Engineering and Hitachi Shipbuilding and Engineering have announced their intention to "undertake construction of chemical plants using bio- technology." In addition, major companies that specialize in planning such as Chiyoda Chemical Engineering and Construction and Sumitomo Chemical Engineering are competing for orders for facilities to prevent biohazards in testing facili- ties. Also, general tradir.g companies are watching the situation carefully. Mitsui and Co Ltd is actively working to effect a tie-up between U.S. business ventures and Japanese industries. Marubeni, Ito Chu, and Tomen also have ambi- tions: "We want to get involved in pharmaceuticals and industry. In technology, expectations center on the following processes in the order given: gene recombination, fixed fermentation, semisynthesis using fermentation, cell fusion, and large-scale cultivation of cells. Gene recombination Cechnology is ~onsidered to be a central part of biotechnology. Many companies "are in the process of learning" about it (Takeda Chemical Industries Ltd, Fujisawa Pharma- ceutical Co Ltd, A~o no Moto Co Inc, and Mei~i Confectionery Co Ltd) and are work- ing hard to secure the necessary technology. Some concrete results can be expected in 1 or 2 years. It is generally felt, however, that cell fusion has more practical value than gene recombination in the near future--for example, for use in diagnostic drugs. There is also strong interest in applications for improvement of agricultural products, not just pharmaceuticals and diagnostic medicines. The fixed fermentation process Is being applied to the production of amino acids and fats and oils and to research and development of synfuel alcohol. Companies which have gotten results with these technologies such as Tanabe Seiyaku, Miyoshi Oil and Fat, and Kansai Paint are rclying on biotechnology for manufacturing. � 22 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFICIAI. USE ONLY a~ - .~"~S : ~'K. s 6 ' i: ~r. . j+ 'f',4,`~~. . + Y-'. - Culture tank for production of interferon (Central Rese arch Laboratory of the Green Cross Corporation) `l'-~~r~et ~'ie?ds cf Corlmercializat.ion for ~Siotechnolo:~;;r - . , ~ _ - r- ~ ' l,. ra~:r:~-.ceuti.ca?.s ~ ~ ehemicaZp '``ener~;~;~ ~isce~.~.aneou~ ' � i f ood pr ~ducts~.. . ~ , i ~ ~ 44 ~3 ~ ~ `~lo % 23 ~ . . . , ~ ~ 1~`~ ~ ~ ~ . Tar,~+:t Dwtes for Bi4technolo{~y Co-imarcialization llOt set ((~.6) 1 yeax ('7.1) , ~yl~e~d-:T in u~o (15~~ . - 2-3 years (1~..,) i~ ~ %1 . ~ l�')-~ ycnr~U (7.4 ) targot date. ; 9rj co~npanie~ 1 155 Projocts . r �n (',",~.5) ~ � 4-5 ,ye~.r:+ (~?'7�"O ,-1 ) ; c;a~ ~ ~ Research: Trying To Catch Up With the United States and Europe in Quantity and Quality; Positive Approach to Business Tie-ups Of the 80 companies undertaking or planning to undertake business related to bio- technology, 62 companies already have a related research department. Seventeen companies do not have a special research organ but are beginning to conduct research. Pharmaceutical manufacturers which specialize in organic chemicals and even ordinary chemical manufacturers have already set up bioscience research , centers. For example, Mitsubishi Chemical Industries established such a research organ as a separate company 10 years ago, in 1971. The research capability of such companies is rapidly taking shape. 23 FOR OFFIC(AL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R440400050006-6 roR oE~Ficin~. ~~sH: c~Ni.v I~uL luukiil~ at the overall situation, there are many companies which are not yet ~~yu.i_ppecl t~ handle this new technology. Also, 4G of the companies, more Chan half, re5poncled that they have less than 10 researchers (including the "several" cate- hory). 'I'hen there were 20 companies which had from 10 to 49 research personnel. ~)nly 9 companies had 50 or more. Biotechnology is said to require "a human wave oL geniuses." Considering that a U.S. genetic engineering venture, Genentech, has 60 researchers with doctor's degrees, it cannot be denied that we are behind the United States and Europe in both quantity and quality. ~t ~~fR~rtDJl~ 1 flf ~~~t~~ - - ~ c~ a~~ t~t ! c~~ ~t 5 6 , ~o ~ i5 ~ u 4: _ 10 ~ 5 10 ~ 7 5 5 4tt a 4~ ~ ~ . 2 ~ 231 0 ,.ta "~o so iao ~ i ~ io > t ~ ~ 8.~ 9 i ~l0~ot11~ 6~~~ 4i ~ k !9 19~ ~1 ~f7 8 ~ 9 '10 ~ ~ s _ x t Key: Key: 1. 44 companies 1. Research and Development Investment (note: 2. 20 companies 36 companies did not respond) 3. Number of Researchers (note: 2. companies 13 companies did not respond) 3. 2 companies 4. 5 companies 4. 19 companies 5. 4 companies 5. 36 companies 6. (including "several persons") 6. 25 companies 7. 10 or less 7. 4 companies 8. 10-49 8. less than 10 million yen 9. 50-99 9. 10 million yen to 100 million yen 1(l. 100 or more 10. 100 million yen to 1 billion y~n 11. more than 1 billion yen 'I~t~~~ mci.in problem is ~etting the pereonnel (reaearchers) . Of 86 companies, 32 are ~~~u~;uplinracticetinhtheeJa~aneseeemnlo mentisistem~~pThisnshowsahowrmuclhli hS ualit t P P Y Y' Y re:;c~archc~rs ~re needed for biotechnology and how desperate many companies are for ~~cr5onnel . lic~c~au~;e of this situation, all of the companies are diligently working to train E~~ople quickly. Looking at the methods of personnel training (composite answers), 53 companies said,that they rely on in-house training. However, even more compa- tiies (59) send their people to educational institutions within Japan, while 32 companies send their people to overseas educational institutions. Aji no Moto ~~rides itself on being the world leader in fermentation technology. However, according to the president, Katsuhiro Utada: "We are continually sending our per- :;onnel as students to educational institutions such as Stanford and MIT in the tini.tecl States and Tokyo University and Kyoto University in Japan and we are careful ~~ot to have the relationships cut off." 24 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 With respect to research and development investment, four companies are spending more than 1 billion yen annually: Mitsubishi Chemical Industries (2 to 3 billion yen), Sumitomo Chemical Industries (several billion yen), A~i no Moto (approxi- mately 2 billion yen)~, and Ringen (approximately 1 billion yen). The largest group, 25 companies, spend between 100 million yen and 1 billion yen. Compared to the generosity of Dupont, which gave 6 million dollars to Harvard Un3versity for biotechnology research, Japanese companies still have a long way to go. Hourever, - we can see that in reaearch investment as well as in personnel education, they are quickly building up their capability. There are also many companies eager to make tie-upa with other companies for research and development and pereonnel training. The poll showed that 40 companies have already made tie-ups or are in the proceas of doing so. Several tie-ups have been made with U.S. business ventures such as Mitsui Toatsu Chemicals and the Green Cross Corporation with Gennex. Most observers believe that there will be an increasing number of companies who use tie-ups with other companies to secure new technology more quickly at the stage where their own accumulated technology has reached a high level and their development goals are clear. One aspect of biotechnology is its use in diversification, for example the develop- ment of inedical products or fertili2er additives by a petrochemical manufacturer. Many of the people involved declare: "In commercializing, one cannot avoid tie-ups." Method of Poll A questionnaire wae sent to 200 important companies involved in the field of bio- technology such as chemical and food companies. Replies were received from 132 companies by the end of June, and the results were analyzed. Together with ques- tions on the companies' business plans and research organizaCions, the opinions of reaearch and development aupervisors were surveyed. Of the companiea which responded, 85 companies submitted the main points of their answers in the form of a chart. The following companiee did not submit because of format limitatione or the deaire noC to reveal heretofore unpublished information: Nippon Oila and Fats, Fu.~.isawa Pharmaceutical, Wakamoto Pharxnaceutical, Kaken Chemical, Santen Pharmaceutical, Amano Pharmaceutical, Ishihara Sangyo, Nippon Noyaku, Tokuyama 5oda, Mitsubiahi Gas Chemical, 5hinetsu Chemical Industry, Nippon Synthetic Chemical Industry, Nippon Synthetic Rubber, Nippon Sanso, Hoya Glass, Sakai Chemical Industry, Chiba Buta~ien Industry, Nitta Gelatine, Jomo Nenshi, Honshu Paper, Kanzaki Paper Manufacturing, Japan Tobacco and Salt Public Corpora- tion, Mitsui Norin, NitCo Seifun, Toyo Sugar Refining, Kyodo Shiryo, Fu~i Seiyu, Yoshihara Oil Mill, Prima Meat Packers, Ito Ham Provisions, Hayashikane Sangyo, S B Food ProducCa, Okura Shuzo, Chlorella Industries, Kawasaki Heavy,Industries, Tsukiahima Kikai, Nikkiso, Mitsubishi Electric, Mitsubishi Corp, Mitsui and Co, C. Itoh, Marubeni, Sumitomo Shoji, Niasho-Iwai, Tomen, Kanematsu-Gosho, and Nichimen. We surveyed the opin~.ons of executives in charge of biotechnology and department - managers of 132 companies which have a strong relationship with biotechnology. They believe that this ie a promiaing technology with great importance for the next generation. They have confidence in the posaibilitiea of commercialization and are dealing with it rationally. We compiled the repliea as follows: 94 percent believe 25. FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R044400050006-6 FOR OFFI('IA1, l~tiE ONI.Y , tl~;� I~i~,~~~rl~noloby ~atll contribute to the happiness of mankind. Four out of f.ive l~~l[tve that the level of Japanese technology will be up with the United States witt~in 5 years. However, more than half believe that "administrative restrictions" and "citizen's movements" will create obstacles to the commercialization of bio- technology and many said that the recent boom in biotechnology is building up excessive expectations. ~1~~f~'?~'/o'r-C~A~~'~0~##tt:.$t~1.~3b+ ~ c~a~stiu25~~) Key : I l. Do you think that biotechnology will contribute to the happiness of mankind? 2~ $ 3 1181~ (126 total respondents) , ~ 2. Yes ~ ~ 3. No 3~:~~~t~` ~ 3~ 4. Other answer ~ 5. What is the Japanese capability in gene 4 ~o~~ ~5w recombination? (128 total respondents) ' S~~~~iM~.~~`T~*~~~ . 6� Will be equal to the United States in t~~Ht~tze~~> 5 years 7. Will catch up with the United States in ;~~E:his 62~ 2 or 3 years *r~a~. 8. Gap,between Japan and the United States ~~2~3'~T~ 311~ and Europe likely to continue p~ic~~ c ~ 9. Already equal to the United States and ~ ~c~t~~~~^ ~ Europe 13~~'~~ ~ 10. Other answer 9trr~c~~~,5~'. . _ . ' i !t . , ~ ~ ~ . I ~ ~ ~ II I I ~ a~ 1l a~i'f'~" VI tive H iene Laborator High- Preven Y National Yg Safety Test Facility Made for International Communicable Disease Program . 1. When do you think that biotechnology will ~ become a 1-trillion-yen industry? A 3- trillion-yen indusCry? 2. 1 trillion yen market ?t~(~}+~7/ ''~~~~1~( 3. 3 trillion yen market 1 ~~ts ~ , ~t ~~~~th~ 4. lare 1980's ~~~4 ~ 5 . early 1990 `s 6. late 1990!s 7. 21st century gp. 8, other answer ~ ~ . ~.~x * ~ ~ _ e~~t~e~t..^~arir~li � 26 . ~ ~Ei~C1~FO~il~t'1!~'~ ( P 4 ~ ?FICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2047102109: CIA-RDP82-00850R400404050046-6 ~ What do you think will restrict the application of bio- f B~r'~'~~r~~�~s-4t~t technolo to industr in Ja an? (125 res ondents) ~.ri-iGAi'~'~'~~e,'~l:~~IM~4t~t.: ~ gY Y P P ~ atafif~'rLx3~.' ` t11ALll;h) ~ . ~w-;,.+ (1) social restrictions related to safety and life ~ ; ' ethics 81 _ (2) administrative restrictions such as testing .l0.~ i guidelines for gene recombination 75 ~ 4~ Y . (3) economic restrictions such as the burden of " m'~4u~~'~~~~--~�~-~31J1 research and development costs 52 ~'m,~~ }5� (4) personnel restrictions such as a lack of ~ ~ - ~,'~,1HE~M! ~ . . . . . researchers 42 ~!I!~!~l~~"'".r",~~.' . , ~#x~~`~+~~ , ~ (5) technological restrictions such as intrinsic 'm~~~'~'~~~~A~ ~ limitations in biotechnolo itself 23 ~ ~~a~~ar , gy } ~ � (6) other answer 6 Market: Ma~ority Believe It Will G~ow to 1 Trillion Yen in 10 Years; Gene Recombi- nation Technology to Catch Up with the United States in 5 years; Opinion Poll of Related Executives and Department Managers Firat, opinions emphasizing the importance of the world to be opened by biotechnology were evident. "To put it strongly, we are approaching one of the greatest turning points since the beginning of mankind" (development department manager of a trading company). "It is an effective means for solving the food shortage of the 21st century" (development department deputy manager of a major sugar refiner). "After electronics, it is the second most revolutionary technology since the war. I ~ believe it is a meaas of solving the world's fuel and food shortages" (director and production technology group general manager of a ma~or fermentation company). What size worldwide.market will be formed by biotechnology and at what time? In the survey, we asked when the market would reach 1 trillion yen and 3 trillion yen. _ A majority ~52 percant) responded that a 1-trillion-yen market would be created by the early 1990's. In other worde, the respondents believe a 1-trillion-yen market is poesible in about 10 years. The largest number of respondents, 42 percent, thought that the tnarket would expand to 3 trillion yen by the late 1990's. However, 30 percent thought that it would take until after the beginning of the 21st century. So there was quite a divergence of opinion on the pace of market expansion. Some observera in the United Statea say that there will be a 6-trillion-yen market in the 1990's. Compared to this, the eatimates of Japanese companies are very con- servative. In the United States, this technology is expected to expand to agricul- tural fields, euch a3 seeds~ and to energy. In Japan, developments are expected to concentrate on pharmaceuticals and chemicals. Perhapa this difference in approach is reflected in the estimates of market size. Next, we asked what percentage of chemical procesaes using high temperature, high pressure, and large aquipment will change to ~nergy-saving processes at ordinary temperatures and pressurea. The overwhelming response was less than 10 percent in the next 10 years. Fifty-three percent of the respondents said 10 to 30 percent in 20 years. Narrowing it down to only thoae respondents involved in chemical indus- tries, we found that 64 percent replied 10 to 30 percent in 20 years. This means 27 _ FOR OFF[CIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFICIAL USF, ONLY th~~t in the firat part of the 21st century chemical industries are expected to et~ow a great change becauee of biotechnology. We can see a readineas for t}ie change. However; opinions like the following were also hearfl. "The reaction of living organisms is slow and catalysts for fermentation are unreliable. It will be dif- ficult to use them in the manufacture of petroleum products in the near future" - (technological research department manager of a chemical manufacturer). "Bio- technology will soon have a central role in a technological revolution in medicine. But its application to chemical industries will be limited for some time" (director and research and development manager of a ma~or chemical company). What is the capability of Japanese technology in the field of biotechnology? We asked the individuals involved how they would rate this level f~r one of the newest technologies, gene recombination. Only 4 percent replied that "Japan has already caught up with the United Statea," 24 per,cent said that we would be "equal with the United States in 2 or 3 years," aad 48 percent or almost half of the respondents believed that we would "catch up in 5 years." As was the caee with semiconductore, we have been told by many observers in the United Statea and Europe that Japan will soon catch up in gene engineering. Most , of the relevant pezsonnel of these Japanese companias also believe that "this will happen in 5 years." This shows that Japan is rapidly gaining confidence in this field. Already some people are saying: "Biotechnology fits Japanese culture. It is possible that Japan will soon be the world leader in this field" (pharmaceutical planning department member of a ma~or liquor company). On s:he other hand, 13 percent of the respondents said that "the,gap between Japan and the United States will continue for some time." Also, there are many requests for improved capability. "Unfortunately, the talented people in this field are going overseas. We need poeitive action by the government and financial sector such as economic assietance, improvement of faciliCies, and relaxation of regula- tions" (developmant~office director of a seed manufacturer). "If we are to expand the fields of application for fermentat~.on technology, which is very advantageous for Janan, more effort muat be put into basic and peripheral technology" (director and research and development divieion manager of a chemical product manufacturer). Although companies which are not involved in biotechnology say that it has "great merit," it is clear that they are hesitatiag. Thie technology is based on basic research in a broad range of ecientific fielde including biology, agriculture, medicine, biochemiatry, chemistry, and biophy$ics, so haste is not in ord~r. Another problem ie the rather large research and development cost required. The products must be narrowed dowa to those with high added value. All companies, including those not yet actively involved, have very high expectations of biotech- nology. An Issue: Wariness of Emotional Reaction; Viewpoint of "Life Ethics" Cannot Be Ignored Many respondents said that "social reatrictions related to safety and life ethics" and "administrative restrictions such as testing guidelines for gene recombination" are important problems in promoting business in this field. Three out of five 28 , APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R440400050006-6 ~ iE ONLY respondents consider that these two things are obstacles. On the other hand, those � who picked "economic restrictions such as the burden of research and development investment" and "the difficulty of securing human resources such as researchers" did not constitute a majority. In ahort, the results showed that even though the companies are hi.ghly motivated, they are afraid that citizens' movements and overly stringent government regulations will shackle positive progress. - On the other hand, there were many who consider that safety measures should have priority. "Measures should be tak~n by the government to prevent those who have not received training from lightly indulging in ~experiments" (research and develop- ment planning department deputy manager of a ma.~or textile manufacturer). "This field involves certain dangere, 3ust as does nuclear energy, and sufficient con- sideration ahould be given to respect for human life" ~technology promotion depart- ment aupervieor of �at and oil company). In addition, admon~itions against racing - ahead recklesely stood out. "For eaample, cloning technology ie a field where the ethical view of ecientiets becomes very important" (director of applied development laboratory of beer company). "Even in Japan, Che people are likely to be critical of thia type of research. We ahould remember that the commercialization of this technology is posaible only if it is socially accepted" (deputy director of research labor$tory of food products manufacturer). Companies which cannot decide whether to enter this field or not gave the following sorts of~opinions. "Pharmaceuticals and increased food production are fields where microorganisms and plants can be used. However, it is not permissible, for ethical reasons, to fool around with animal genes. The very study of cloning of animals or human beings should be forbidden" (central ]:aboratory director of chemical manu- facturer). "Even if new products are useful for particular human purposes, might they not ~ destroy the balance of the natural world?" (deputy director of research and develop- ment office of oil refining company). It is interesting that there were many respondente in industry who coneider that becauae biotechnology is a very promising and revolutionary technolagy~ commercialization should be carried out circumspectly. There were only 3 respondents out of 126 who anawered "no" to the question "Will biotechnology contribute to t~te happiness of mankind?", while 118 respondents answered "yes". However, of those wha answered "yes", there were only a few wt~o were as uncondi- tionally positive as in this opinion: "Biotechnology has technological limits. There fs no danger of repetitive self-propagation of monsters" (director of central research laboratory survey and planning office of a food products manufacturer). Moat respondenta wanted to apply conditions even though they believed that biotech- nology could contribute to the happiness of mankind. "Whether it can be useful or not is a problem for human beings." "A necessary condition is the establishment of a social ethic under which only research whtch aims at increased human happiness is allowed" (life ecience researcH laboratory director of ma3or fat and oil company). 'ro summartze, biotechnology is atill a young area of science~ and technology. It should be evaluated rationally and cultivated with understanding. For this pur- pose, proper guidance and measures for cultivation by the government are indispensa- ble. Also, it will not do for the gener.al populace to have excessive expectations derived from science fiction or to protest on the basis of emotion alone. The prob-- lem is what specific actions will be taken by industry Co create the proper environ- ment for progress. 29, F4R OF~ZC'[AL U3L QAILY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R044400050006-6 FOR OFFICIAL USE ONLY Business Plans Related to P,iotechnology Research Capability Business Field Technalogy Used ime Needed Name of No. of Company Name Research research- or Commer- ialization Organ ers Pharmaceuticals Takeda pharmaceuticals cell fusion, gene 5-8 years Biotechnology 30 Pnarmaceutical recombination and Laboratory, Industries other arrangement Fermentation Products Lab ~ . an yo o p armaceut ca s ce us on, gene years ermentat on sever~3 recombination Laboratory onag o p armaceux ca s gene recom nat on - years several plant and animal fixed ~nzyme medicines, clin~ fermentation, ical diagnoatic cell fusion medicines ana e e ya u a no ac s, xe m croorgan sm a rea y pp ie io- organic acids method applied science Lab, = Microorganism Eisai Co physiological gene recombination 10 years Bioscience . several active substances cell cultivation Group Yamanouchi pharmaceuticals aemisynthesis 5 yeare Cell Physiology Pharmaceutical uaing fermentation Laboratory cell fusion Banyu antibiotics gene recombination R&D Group several Pharmaceutical cell fusion Office Yoshitomi pharmaceuCicals gene 'recombination 5-6 years Central several Phar~aaceutical Laborator Mochida interferon cell cultivation unknown several Pharmaceutical diagnostic test cell fusion 2-3 years chemical Otsuka interferon cell fusion 5 years Cell Technology approx Pharmaceutical Research De t 30 Tokyo Tanabe Co pharmaceuticals fixed fermentation 3-4 years Natural Sub- several stance Lab Riken Vitamin food producta fermentation~ . 1-2 years Chemicals � Mitsubishi pharmaceuticals geae recombination 5-10 yrs Bioscience Lab, Cheinical chemicals semisynthesis using " Biochemistry several Industry fermentation Lab, Technology tens Laboratory food products fixed fermentation alre~dy . applied diagnostic test cell fusion in 1981 chemicals 30 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 ~v `-~-+"~~~"`r'~- Fermentation and Biology-Related - Training and Employment R&D Expenses Business Already Undeztaay Plans (1981 Plan) in-house training, overseas pharmaceuticals, amino acids, education, new graduate nucleic acids employment, midcareer employment in-house training, new p armaceut ca s, yeast ermentat on graduate employment in-house training, outside approx ~ p armaceut ca s education in Japan and over- million yen seas, new graduste employment, midcareer employment in-house training amino acids, organic acids in-house training, outside small pharmaceuticals, animal medicines, education in Japan amount food product ingredients , in-house training, overseas ant ot cs educat3.on, midcareer employment in-house training, outs e p armaceut ca s ~ education in Japat~ outside training in Japan an p armaceut ca s overseas, n~w graduate and midcareer employmeat enzymea, hormones new gra uate an m career approx em lo ent million yen in-house training, oute e enzyme ~aanu actur ng agents or education in Japan, medical uae in-house training, outside 2-3 billion steroids, diagnostic test chemicals, education in Japan and yen isomerized sugar, soybean milk oveXSeas, new graduate employment, rnidcareer employment 31 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 FOR OFFIC[AL USE ONLY (taUle continued) Sumitomo pharmaceuticals gene recombination 7 years Bioscience Lab Chemical interferon cell cultivation 5 years Pharmaceutical - chemical bioreactor 10 years Div Research - roducts De t Showa Denko amino acids gene recombination 2-3 years Bioscience Lab Mitsubishi pharmaceuticals, gene recombination, 4-10 years Central Research Petrochemical agrichemicals, cell fusion, cell Lab, Mitsubishi diagnostic test cultivation, Petrochemical chemical fermentation Pharmaceutical roducta Laborator Mitsui Petro- physiologically fermentation, cell 2-3 years Comprehensive chemical Indus- active sub- fusion, tissue Research tries stances cultivation Laborator Kanegafuchi intermediate semisynthesis already Bioscience - Chemical pharmaceuticals, usi~ng fermentation, applied Laboratory Industr harmaceutieals ene recombination 2-3 ears SeiteCsu Kagaku pRarmaceuticals synthesis using 3-4 years Research Dept and inter- fermentation Bioscience Group ediates Toyor Soda sweeteners fermentation 2-3 years Planning Lab ph~rmaceuticals gene combinatinn 5-10 years enzyme analysis 2-3 years e ui ment Nippon Soda pharmaceutical~ gene recombination 5-6 years Bioscience Lab nd fermentation chemicals " " 8-10 ears Asahi Denka food producta fixed fermentation 3-4 years Food Products chemical emisynthesis 5-6 years and Oils and producta sing fermentation Fats Development Laborator Chisso pharmaceutical fermentation 5-6 years Development companents Office, Yokohama Branch Nihon Shokubai chemical gene recombination 10 years Cencral Ka aku Ko o roducta Research Lab Sekisui Kaseihin se of uriused semisyntheais 5-7 years Ko o resources sin fermentation . Asahi Glass field being &D Dept ~ elected Nippon Paint harmaceuticala ell cultivation 5 years echnology chemical ene recombination Center ubstancea nd cell culture Kansai Paint chemical fixed fermantation 4-5 years echnology roducte acterial method rou Dainippon Ink ood producta ell fusion 5-6 years ioscience and Chemicals hemical ivision roducts 32 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 sevezal in-house training, outside several tens training in Japan and overseas, billion yen employment of new graduates and midcareer em lo ent several in-house training, outaide amino acids, etc , education in Japan, employment u on raduation and in midcareer i:n-house training, outside heat resistant enzymes _ education in Japan and overseas, employment upon graduation and in midcareer approx IO " " approx 200 million yen approx 100 outside education in Japan and bread mold, glutathione overseas, employment upon raduation and in midcareer several outaide education in Japan, 20 million employment of new graduates yen , approx 30 in-house Craining, outeide 300-400 � education in Japan, employment million yen upon graduation and in midcareer _ several outsid~ education in Japan and urokinaze (pharma- overseas, new graduate employment ceutical) . several in-hause training, new graduate 50 million employment yen approx 10 in-house training, employment 50 million upon graduation or in midcareer yen several outside education in Japan, em lo ent in midcareer several drainage water tr~at- ment rocess several new graduate employment 10 million yen several ~ several in-house training, outside approx 100 micrabial. protein education in Japan, new million yen graduate employment 33 FOR OFFICIAL U~E ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R440400050006-6 FOR OFFICIAL USE ONLY Kyowa Hakko pharmaceuCicals gene recombination 5-6 years Tokyo Lab, Kogyo amino acids gene recombination Technology special anti- cell fusion and Laboratory bodies, enzymes large-scale culti- vation alcohol fixed bacterial � method Nippon Kayaku pharmaceuticals gene recombination -6 years Pharmaceutical and cell fusion Div Pharma- chemical gene recombination 10 years ceutical Lab, - products and fixed fermen- Agrichemical tation Div Jomo Lab, Technological Development Dept Takasaki Lab Kumiai cell wall dis- Bioscience Lab Chemical solvin enz Hokko Chemi- antibiotice gene recombination -10 years Induetr Kao.Soap food products gene recombinaCion -6 years~ Bioscience Lab - chemicals fixed fermentation " Lion Fat and biomass develop fixed fermentaicion 0 years Bioscience Lab Oil ment plant breeding gene recombination -4 years oil and fat cell fusion, etc -4 years manufacturing enzymes for gene recom'uination -5 years medical use Miyo~hi Oil lipid synthesis fixed fermentation -4 years Manufacturing and Fat Grou Sanyo Chemical chemical fixed fermentation -6 years Planning and Industry producte Development Group, Planning De t Shin Nippon chemical fermentation, fer- -7 years Rika producte mentation using enz es Sun Star interferon ce11 cultivation -7 years Bioacience Lab Dentrifrice antibiotica cell fusion -10 ears Textiles~ Palper and Pulp - Asahi Chemical urokinaze tisaue cultivaCion -6 years Technology Lab, Industry Research Section of Food and ' Pharmaceuti.cal Plants Toray interferon gene recombination few Basic Research ears Laboratory various am~.no technology apply- acids in enz es 34 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 approx 40 in-house training, outside 700-800 pharmaceuticals, alco- education in Japan and overseas, ~illion yen hol and fuel, amino employment upon graduation and acids, enzymes, etc in midcareer several outside education in Japan, 30 million pharmaceuticals, _ employment of new graduates Yen amino acids aeveral agrichemicals ~ agrichemicals ~ 40 in-house training, outside 500 million production of surface- education in Japan and overseas, yen active agents ~ t �of .new.. re~uates approx 1~0 iix-house training, outside 900 million soap containing enzymes education in Japan and overseas, yen employnsent of new graduates and eople in midcazeer several in-houee training, employment 20 million fat and oil analysis of b~w raduatea en _ several i~t-houss training, outmide ducatioa in Japan~ employmant f new graduatee and people in idcareer approx 15 verae8s education, employment 250 million f new raduates en utside education 3n Japan and sodium glutamate, verseas, employment of new harmaceutical radua~es � ingredients - n-house training, overseas harmaceuticals, amino ducation, employmAnt of new cids raduates and people in midcareer 35 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R440400050006-6 FOR OFFI('fAl, USf: ONLY Teijin pharmaceuticals gene recombinaCion, 5-6 years Biomedical Lab chemicals fermentation and 8-10 years Central tissue cultivation Laboratory , Basic Research De t Kanegafuchi pharmaceuticals cell fusion and 5-6 years Pharmaceutical Spinning cell cultivation Research pharmaceuticals fixed enzyme 7-8 years Laboratory fermentation Unitika pharmaceuticals fixed enzyme 4-5 years Central fermentation Research Lab, chemicals No 3 Lab Kuraray pharmaceuticals gene recombination 5-6 years Central cheraical fermentation 3-4 years Research producte Laboratory, agricultural an gene recombination 10 years No 3 Lab � live~tock roducta Mitsubishi al'cohol fixed enzyme 1-3 years Central Rayon ~ fermentation Research Laboratory, No 8 Research Grou Nitto Boseki pharmaceuticals fixed enzume 10 years Development fermentation Laboratory limi.ted en$ es Koh~in phar~aceuticals gene recombination 5-6 years Saeki Plant che~airals semisynthesis 2-3 years Research Dept uein fermentation 0~1 Paper timber breeding protoplasr eepara- 5-6 years Timber Breeding tion and cultiva- Laboratory tion technology~ cell fueion Sanyo Kokusaku tieeue cultivation, 4-5 years Iwakuni Pulp fixed enzyma Research Lab, - fermentation Etsu Branch, Fercdentation Grou Jujo Paper pharmaceuticals semisynthesis Central food products . Research Lab, Chemical Products Grou Food Produc~e Kirin Brewery new yeast breed cell fusion, gene 10 years Comprehensive ing technology recombination Research new bariey b~e~ed gene recombination 10 years Laboratory in technolo cell cultivation Suntory phyeiologically gene recombination 10 years Biomedical active peptides Laboratory, food~producte fixed enzyme Central fermentation Research Lab 36 FOR OFF[CIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 in-house training, outside education in Japan, employment of new graduates approx 10 " " 40 million pharmaceuticals yen approx 20 in-house training, outside 300-400 education in Japan and overseas, million yen e~loyment of new graduates and eo 1~ in midcareer several outs~de education in Japan and 100-200 drainage water treat- over~eas, employment of new million yen ment with micro- graduates and people in . organisms midcareer 4 3n-houae training 30 million ' yen several fn-house training, outside 50 million amino acid synthesis, education in 3apan, employment yen enzyme fixing of new raduates approx 20 outs3d~e.educatinn in Japan, approx. 100 yeast, enzymes employment of new graduates million yen 10 outside education in Japan, SO million forestry employment of new graduates yen and people in midca~eer several in-houee tralning, outside 50 million protein yeast, education in Japan, employment yen ribonucleic acid af new graduatee several in-house training, yeast, nucleic acids employment of new graduates ~ several in-house training, outside several tens beer brewing, plant ~ducation in Japan, employment of millions and microorganism of new graduates and people of yen enzyme production, in midcareer malt roduction approx SO in-house training, outside liquors, food pro- edueation in Japan and overseas, ducts, pharmaceuticals employment of new graduates and eo le in midcareer 37 FQR OFFICIAL US~ UNLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R440400050006-6 FOR OFFICIAI. USE ONLY Sapporo food products cell fusion 8-12 years Central Lab, Breweries (yeast, etc) Applied Develop- ' seeds tissue cultivation 10-15 yrs ment Lab, Raw pharmaceuticals gene recombination 10-15 yrs Material Testing Lab Asahi food products gene recombination 3 years Central Brewpries pharmaceuticals enzyme fermentatio 3 years Research Lab agricultural an cell fusion livestock roducts Toyo Jozo Bioscience Lab ~ Sanraku Ocean alcohol fixed yeast 5-6 years Central ~ fermentation Research Lab amino acids gene recombination 5-6 years antibio~ics cell fusion 5-10 ear Godo Shusei ethyl alcohol fixed enzyme 3-4 years Central fermentation Research Lab biomass product~on of high S-6 years coave~sion erformance bac~ri Aji no Moto amino~~acids gene recombination 3-5 years Central fixed enzyme 2-3 years Research Lab, fermentation Bioscience Lab Kikkoman phyaio7.ogically semisynChesis 3-5 years Central activa - ~using fermentation Research Lab, substances Noda Industrial Science Lab Foundation Chukin vinegar mfg gene recombination, 5-6 yeara Chukin Vine ar tixed fermentation Bioscience Lab - Snow Brand dait'y products tixed anzyma already Technology Milk Producte fermentation applied Reeearch Lab food producte ue~ of new enzymes 1-2 yeara Bioscience Sec. microorganiema phax~saaceuticals aemisyntheais 3-4 yeara using zymotic microar aniams Mei~i Milk food products~ gene recombination 10 years Bioscience Lab Products harmaceutic~l.s Yakult pharmaceuticals gene recombination 5-10 year Central food products " " Resear.ch Lab Calpis Food antibiotica semisynthesis 5-10 year Tokyo Research Industry using fermentation Laboratory, antineoplastics cell ufsion Basic Research Sec. ~ = 38 FOR OFFICIAL USE ~ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400054006-6 - approx 50 in-house training, outside 20 million alcoholic beverages education in Japan, employment yan of new graduates and people in midcareer 20 in-house training, outside eer, malt, yeast education in Japan and overseas, employment of new graduates approx 30 in-house training, outeide alcoholic beverages, education in Japan and ovezseae, harmaceuticals, em lo nt of new raduates food roducts 60 in-houee training, outside 400 million training in Japan and overseas yen approx 20 in-houae training, outside approx 100 drinking alcohol, education in Japan, employment million yen enzymes, alcoholic of new gratduates and people beverages in midcareer approx 150 in-houae training, outside approx 2 amino acids, nucleic education in Japan and overseas, billion yen acids, yeast, em lo nt of new raduates harmaceuticals approx 40 in-house trainirig, outside approx 800 soy sauce, alcoholic education ia Japan and overseas, million yen beverages, food e~ployment of new graduates and products, alcohol people i.n midcareer several in-houae training, outaide 50 million vinegar manufacture educatiion in Ja an and overaeae en approx 50 in-houee trainittg. ou~teide 500-700 cheeae, lactobacilli, sducation in Japetn and overeeae, million yen fermented milk drink, etaployiaent of new graduatee pharmaceuticals several in-house training, outside undetermined fermented food products education in Ja an approx 20 ouCside education in Japan, fermented milk drink, employment of new graduates and fermentation agents, paople in midcareer lactobacillus agents in-house training, outside fermented food and education in Japan beverages, plant and - animal food products n 39 FOR OFFICIAL USE ONI.Y APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400054006-6 FOR OFFICIAL USF.. ONI.Y - Meiji Seika antibiotics gene recombination 1-2 years Central enzymes cell fusion " Research Lab, physiologically fixed bacteria " Pharmaceutical active peptides method, enzyme Development fermentation Research Lab, Fermentation Technology Lab Pharmaceutical Develo ment Sec. Morinaga pharmaceuticals gene recombination 5-6 years Bioscience Lab Confectionery food products " chemic~tle " s~eds cell fueion " Meito Sangyo synthesized fermentation already Fermentation producta (yeast) applied Development Dept, Synthesis Develo ment De t Mitsui Sugar food products fixed enzyme within 3 R&D Dept mxde by combi- fermentat3on years nation and - conversion of di.saccharides Taito food products semisynthesis several usin fermentation ears Hokkaido food products Fermentation Sugar (beet sugar, Plant Research maltose Section Nippon Shoku- sugars (pharma- fixed enzyme Research Lab hin Kako ceuticals, food fermentation products) dextrine " Ringen interferon ce11 fueion 2 yeara Ringen K.K. dextriae fixed~enzyme already Technology Dept chsmicale fermentation applied Ringen active sub- microorgani~ms " Bioscience Lab stances inside - or anie Oriental breading of cell fuaion, etc 2-3 year~ Research Lab, Yeast y~ast molecules, Enzyme Develop- Industry biochemistry fixed enzyme already ment Center, tee~ chemicals, fermentation applied Biology Lab automatic analy- " 1 year sis e~ui ment Takii Seeda improved vege- cell fusion already Basic Research tablee flawers a lied Laborator Other Manufacturing Industries Idemitsu biomasa energy cell fusion, etc 5-10 year Central Kosan chemical gene recombination more than Research Lab, products 10 years new dept 40 FOR OFFICIAL USE ONLY ~ APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPR~VED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 in-house training~ outeide pharmaceuticals, education in Japan and overseas, foodstuffs, agri- employment of new graduates chemicals, veterinary medicines, enzymes approx 30 outside education in Japan, approx 200 alcohol employment of new graduates million yen people in midcareer approx 30 in houee training, outside approx 200 enzy.mes such as rennet, t~Ainiag in Japan, employment million yen dextran of new graduates several in-house training eucrose manufacturing several ~ outside education in Japan small amount natural pigments 6 in-house training, outside 40 million melibiaze, maltose educat~.an in Japan, yen production enzymes ~ nt of new raduates _ im~+hduee training, outside sugar syrup, dextrose edulcat~,on in Japan, for use in pharma- e~ployt6ent ~of new graduates ceuticals approx 120 outaide education in Japan, a~prox 1 maltose and pururan for employment of new graduatea use in pharmaceuticals, grape augar for use in food, sweeteners aeveral in-housm training, outaide bread yeast, steri- education in Japan, lizing livestock feed, employmeat of new greduates SPF (specific pathogene and people in midcareer free) animal breeding several ~ o e rs n n, ou s e 15 million improvement and sale ~~~~atie~~iof3n.an ab~soverseas, en of seeds several outside education in Japan 100 billion ~ and overaeas, employment of yen , new graduates and people in midcareer 41 FOR OFFICIAL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R440400050006-6 FOR OFFICIAt. USE ONLY Nippon Oil alcohol for fixed microorgan- within 10 Central use as fuel isms years Research Lab pharmaceuticals fermentation by 3-4 years variant roota Hitachi Ship- chemical produc bioreactor 5-6 years Technology building and tion equipment Research Lab, Engineering Chemical Research Section Mitsui Ship- pollution high-density in 1981 Bioscience building and prevention aontinuous Laboratory Engineering . � fermentation . slctif3cial � i~ Japan Gaeolin synfuels fixed micro- 2-5 years Technology oY anism method Reaearch Lab - Chiyoda Chemi ~iohsz~rd already cal Engineer- pz~vottti~on applied ing and aquip~tat ' ' Construction Toyo telluloae ~ enzyme reaction undeter- Technolo~y Engineering plants mined Laboratory ~ Process Lab Sumitomo biohazar$ Technology Chemical p+r~vention Dept - En inee'rin e ~ at Matsushita ~eth"sRe produc- btcrmass conver- 1-2 years Energy Con- Electric tios~r'equipment .siqn technology version Industrial btoeei?por fixed enzyme 4-5 years Laboratory, fermentation Matsuehita Battery Industr Lab Fuji biobazard already Electric pXav~ntion applied ~a ~ ii~ 42 FOR OFFICUL USE ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6 APPROVED FOR RELEASE: 2007/02/49: CIA-RDP82-00850R000400054006-6 - several in-house training, outside approx 200 education in Japan, million yen employment of new graduates employment of new graduates equipment for sludge and people in midcareer treatment several in-house training, employment several tens active sludge method, of people in midcareer of millions alcohol fermentation of yen several in-house training, employment 100 million all types of related of ~o le in midcare r en lants several outside education in Japan and approx 100 fermented alcohol ov~raeas, employment of new million yen plants raduatea aad eo le in midcareer several outside education in Japan and 10 million overseas, employinent of new yen r, uates several i~-1i~tlse training, employment several biomass conversion of nati gY~duates amd people in hundred energy midcsreer. million yen COPYRIGHT: Nihon Keizai Shimbuaeha 1981 9651 CSO: 8129/1561 ~D 43 FOB OFFICIAL U3E ONLY APPROVED FOR RELEASE: 2007/02/09: CIA-RDP82-00850R000400050006-6