RESEARCH ON TRICHIONELLOSIS

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80T00246A074700130001-8
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 11
• Document Creation Date: December 27, 2016
• Document Release Date: February 5, 2014
• Sequence Number: 1
• Publication Date: May 1, 1964
• Content Type: REPORT

Declassified in Part - Sanitized Copy Approved for Release 2014/02/05: CIA-RDP80T00246A074700130001-8
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INFORMATION REPORT -- INFORMATION REPORT
CENTRAL INTELLRQNCE AGENCY
This material contains information affecting the National Defense of the United States within the meaning of the Espionlztge Laws, Title
18, U.S.C. Secs. 793 and 794, the transmission or revelation of which in any manner to an unauthorized, person is prohibited by ? law. ?
50X1-HUM
COUNTRY Poland
SUBJECT ResearCh on Trichionellosis
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DATE OF.
INFO.
? PLACE &
DATE ACQ
REPOR1
DATE DISTR. 1 May 6)4
NO. PAGES 2
REFERENCES.
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THIS IS UNEVALUATED INFORMATION
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annual report (seven pages, English) of a
Polish research project entitled "Investigations on Trichinellosis with
Special Reference to gplaootiology, Immunology and Pathogenesis." The
projectle.which is beindtconducted at the Institute of Parasitology at
Warsawlis under the direction of Dr Zbigniew Kozar.
2. The summary of progress:
a. The investigations involve a number of topics, a part of which has
been completed or published (five papers), others are being conducted
or will be undertaken.
b. Epidemiologic and epizootiologic investigations are designed to
establish the incidence of Trichinellaspiralis in people, domestic
and wild living animals throughout the country, the effect of con-
tributing factors and to develop control methods.
c. Among the hitherto examined human corpses (more than 2100 cases)
from various regions of the country, positive results have been obtained
in about four percent. This percentage is lower as compared with that
of the US (16 percent)', but the differences between individual regions
are significant and warrant epidemiologic conclusions. Similar methods
(microscopic and digestive) are used to examine dogsats and wild living
animals. As to the infection in pigs, the analysis.. 1a collected
from all over the country will permit the recogniteillfluence of
? ,
cultural and other factors on the incidence of th In these
animals. The studies are also concerned with th
particularly in rural population from certain regio ie country, as
assessed by allergic tests.
environment,
d. Pathogenesis and therapy of Trichinellosis. To begin with methods
of experimenting and studying the effect of invasion in mice have been
developed the critical review is concerned with some re-
ported methods.
e. The pathogenic problem of trichinellosis is extremely complex and
should be attacked by possibly all available methods. Stme interesting,
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Excluded from automatic
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declassification
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INFORMATION REPORT INFORMATION REPORT
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DO NOT TYPE ABOVE LINE
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so far unknown data have emerged from the studies on the effect of 50X1-HUM
flora in the host's digestive tract on the course of infection
Intravital staining of some host's tissues 50X1-HUM
was employed to learn more about host-parasite relationships
f. More attention is being paid to alterations which occur in host's 50X1-HUM
tissues. The muscles of infected animals (at various time pi) have
been the subject of our hitherto performed studies. Metabolic changes
of the muscles have been examined so far as carbohydrate
lipids and Krebs cycle are concerned; the results Obtained seem to be
of interest. Independently, the activity of some enzymes occurring in
the serum of infected animals and the metabolism of the myocardium are
being investigated. In these investigations, histochemical methods
play a supplementary part. Ther1Ruscular phase of the invasion has been
the subject of numerous ex Tiations; as to the intestinal phase our
studies have been concerned the occurrence and distribution of
some compounds (RMA, DRNA e and the enzymatic activity in the pa-
rasite and surrounding host s,tessues.
g. As regards the parasite, respiratory and metabolic studies were
made on isolated larvae. Eventual differences in the pathogenicity
of individual parasite strains (eg from Africa dnd Poland) were also
investigated.
50X1-HUM
h. The main goal we are aiming at in this field is to obtain an
appropriate therapeutic method. The hitherto applied corticosteroids
are effective clinically, but they result in general, long-lasting,
undesired sequelae. We could demonstrate that a similar clinical effect
but without sequelae is obtainable with plan preparations of azulenes
50X1-HUM
I. In our opinion, trichinellosis of people occurs not only in acute
form (described repeatedly), but also in a chronic one, persisting
occasionally for several years. It is just the latter phase of
trichinellosis which in some countries may become a serious sanitary
problem, that is the main subject of our investigations.
j. In the group of 236 patients, affected by reumatic disease and
subjected to balneologic treatment, 18 cases presented ailments
which apparently could be related to trichinellosis they had years
ago. We also analyzed other post-mortem diagnosed trichinellosis
cases which had reached clinics and autopsy tables with various mis-
diagnosis. Our studies are also concerned with the consequences of
trichinellosis (mostly of the circulatory system) in the group of
patients who had succumbed to the disease a few months ago, as well
as with their treatments.
k. Immunology of trichinellosis. The investigations of this group
aim at the establishment of more detailed information about the host-
parasite system
and at
the development of practical guiding lines for the diagnosis (com-
parison of various reported reactions).
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C0NFIDENTIAI7
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CIA-RDP80T00246A074700130001-8
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WriFtilLiN mu
I. Name 0 .1ustitution:
PoliSh 'Academy of Sciences
Institute Of Parasitology Paa eara, 32 Warszawa
Laboratory of Antropozeonoses2 Norwida 292Wroclaw, Poland
. Name. of principal investigator:
Prof .dr Zbigniew K 0' Z a r
3, Project title:
Investigations on trichinello is with special re
to epizootiology, immunology and pathogenesis.
erence
50X1 -HUM
CONFIDENTIAL ?
uotttalral3aP
put tul5sAnitAcP
tntulops tu,14 pgrA2
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e ?
4) . CONFIDrtn" A
Samar: of progress
The investigations involve a number of topics, a part of which
has been coapletek others ere being conducted
or will be undertaken.
Spidemiologic and episootiologic
investigations are designed to establish the incideno*
of Trichinellaspiralle in people, domestic and wild living animals
throughout the country, the effect of contributing footsie and to de-
velop control methods.
Among the hitherto examined bum corpses (more than 2100 cassia)
from various regions of the country, positive result have been obtal..
ned in about 4%* This percentage is lower as compared with that of
USA (16%), but the differences between individual regions are signifi-
cant and warrant epidemiologic conclusions* Stellar methods (micros-
copic and digestive) are used to examine dogs, oats and wild living
animals* As to the infection in pigs, the analysis of data collected
from all-over the country will permit the reoognition the influence
of *altars' and other factors on the incidence of the parasite in the-
se animals. The studies are also concerned with the effect of envi-
ronment, particularly in raral population from certain regions of the
country, al assessed by allergic tests.
P *those:lassie and therapy of Trichi-
n It 1 losis. To begin with methods of experiaentine and studying
the effect of invasion in mice have been developed the
critical review is concerned with some reported methods * 50X1-HUM
The pathogenlOillroAcm of trichinellosis is extremely complex
and should be attacked by possibly a11 available methods* Some inters*
ting $ so far unknown data have emerged from the studies on the effeot
of flora in the host's digestive tract on the course of inteotia50X1-HUM
Intravital stainig of some host's
tissues was employed to learn more about host-parasite relatioDshits
I II Ill!
50X1-HUM
Nora attention is being Paid to alterations which occur in noev-s
tissues. The muscles of infected animals (at various time pa.) have
been the subject of our hitherto performed studies* Metabolic chamte
of the muscles have been examined so far as carbohydrate
lipids and Krebs cycle are concerned; the results obtained sees to be
of interest. Independently, the activity of some enzymes occurring in
the serum of infected animals and the metabolism of the myooardium
are being investigated. In those investigations, histochamical methods
play a supplementary pert* The muscular phase of the invasion has bee:
the subject of numerous examinations; as to the intestinal phase our
studies have been concerned with the occurrence and distribution of
some compounds (RNA, DRSA act.) and the *wattle activity in the pap.
resit* and surrounding host's tiaras.*
As regards the parasite, respiratory and metabolic studies were
made onibolated larvae* Eventual differences in the pathogenicity of
individual parasite strains (e.g. from Africa and Poland) were also
investigated*
The main goal we are aiming at in this field is to obtain an
appropriate therapeutic method* The hitherto applied oortiiesterolde
are effective clinically, but they result in general, long-lasting,
undesired sequels*. we could demonstrate that a similar clinical effe
but without sequels* is obtainable with plan preparation* of azulanes
50X1-HUM
- In our opinion, trichinellosis of people ()entre not only in ace
term (described repeatedly),but also ins chronic one, persisting
occasionally for several years* It is just the latter phase of
50X1-HUNI
mmFIDDITI AL
Declassified in Part - Sanitized Copy Approved for Release 2014/02/05: CIA-RDP80T00246A074700130001-8
Declassified in Part - Sanitized Copy Approved for Release 2014/02/05: CIA-RDP80T00246A074700130001-8
CONFIDEN IAL
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many years the disease was found neither in the man nor in animals
(province Cracow). The data have been obtained from 951 adults
(rural popalation). In most parts there were negative results but
in some localities there emerged unexpected positive results which
could be later explained in the light of a detailed epidemiologic
and epitootiologic analysis. This fact is an additional support for
the value of the test in mass investigations and confirms our older
vim on the applicability of the allerzio test *-ft
-- MA's oriantikt4en
in opidemiolozical situation
50X1 -HUM
3.1pizootiology of trichinellosis in
swine. By way of personal enquiries and contacts detailed data
were collected on the occurrence of trichinellosis in pigs in the
individual regions of the whole ?pantry. /endemic centres were found
where cases of infection occur every year and areas where oases of
trichinellosis are not recorded for many years. los analysis are
submitted the various opisootiological and other factors. Th, anas.
lysis of the data will be terminated in the next aonthe.
4.Inoidence of Trichinells spiralis in
animals . By means of the two methods (as in 1) simples from
about 1000 dogs and cats and more than 200 wild animals were inv....
tigsted. The material was collected from various provinces of the
country. Attention Is drawn also. to larvae of other neaatodes fount
in muscles, which may be erroneously taken for the Trichinella ler*
vae. Espeoially if wild animals materiel is coming at irregular
intervals these studies mast be prolonged for the next year.
2?Pathogenesis and therapy of trichinel-
louts.
5. Inflaance of B.mesentericas on the de we -
lopaent of trichinellas in aloe ? She
experiments were condmted on mice, males (in 3 series). They were
given per as daring 6 days fresh culture of B.aesenterious? The
first series exhibited 3,46 (170,6 intestinal trio:1112mila., in
1
controls were found 11,71 (_ 1,17 trichinellae. Series II (Bake.
sentericus,during the first 6 days exhibited on average 696,1
( 1- 289,4) muscle larvae. In 59 controls there were on the aver,.
age 1824 larvae (1' 250,4). Series III.(B.mesenterious 6-12 days
P.i.), the number of muscle larvae 1309 ( ? 330,8). In 27 control -
1863 (...! 369,2) larvae. It was proved that the feeding of the im.
footed mice with the culture of S.mesentericas deoreases by 'several ,
times the number of the developing intestinal trichinellae ( P