SOVIET BOOKS AND PAMPHLETS CONCERNING VETERINARY PRACTICE

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80T00246A043800010001-4
• Release Decision: RIPPUB
• Original Classification: S
• Document Page Count: 1454
• Document Creation Date: December 22, 2016
• Document Release Date: May 20, 2010
• Sequence Number: 1
• Publication Date: August 22, 1958
• Content Type: REPORT

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NOFORN
COUNTRY USSR
is material contains information affecting the National Defense of the United States within the meaning of the Espionage Laws. Title
S.C. S3eeg. 793 and 794, the transmission or revelation of which in n.nv ,,,.,,..e.. .
CENTRAL INTELLIGENCE AGENCY
25X1
SUBJECT Soviet Books and Pamphlets Concerning DATE DISTR. 22 August 1958
Veterinary Practice
NO. PAGES 2
REQUIREMENT RD
DATE OF
INFO.
PLACE &
DATE _ACQ.
SOURCE EVALUATIONS ARE DEFINITIVE APPRAISAL OF CONTENT IS TENTATIVE
four Sovi books and five Soviet pamphlets all in
language,
2. A brief description of these publications and their contents is as follows:
Books:
M.S. Gannushkin, The Study of Epizooty with the Fundamentals of Microbiology
(Epizoologiya s osnovami mikrobiologii ,Moscowy 195 pages with photos
and charts. A rather complete text for veterinary students, concerning
communicable diseases among domestic animals.
Ye.S, Cherkasskiy, Distemper in Carnivores (Chuma plotoyadnykh), Moscow,1957,
290 pages with photos and charts, A short text for scientific and practical
workers, giving descriptions, preventatives, and cures for distemper in wild
and domestic carnivores.
Professor I.Ye. Povazhenko, General Veterinary Surgery (Obshchaya veterinarnaya
khirurgiya), Moscow, 1956, 3b -.Pages with photos, X-rays, drawings. A text
for advanced veterinary students, with both theoretical and practical conclusions.
R.A. Tsion, Diseaaes of Young Agricultural Animals (Bolezni molodnyaka
seltskokhozyaystvannykh_zhivotnykh~, Moscow, 195$; 144 pages. Less sophisticated
than the preceding, intended for veterinary interns and other semi-qualified
personnel.
Pamphlets: (All from the All-Union Agricultural Exposition of 1957 and 1958)
V.P. Titov, How to Lijuidate Ringworm (Kak likvidirovat' strigushchiy lishay),
Moscow, 195$, six pages. Extremely basic, intended only as a manual for
literate farmers.
S-E-C-R-E-T
NOFORN
IX ARMY X NAVY x
~CNote: Washington distribution indicated by "X"? Field distribution by "#",)
AEC
Q
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S-E-C-R-E-T
NOFORN
P.T. Lebedev, 98 Calves from 100 Cows (98 telyat of 100 korov), Mcscow,
1957, six pages. In general, merely an exhortation to work harder,
pointing out the successes of an advanced collective farm.
Professor V.I. Zaytsev, et al., Prevention of Sickness in High-Productivity
Cows (Preduprezhdeniye zabolevaniy u vysokoproduktivnykh korov , Pdoscow, 1957,
six pages. An appeal to cut down on the use of food concentrates for milk
cattle because of resultant diseases and other bad effects.
N.V. Zaytsev, The Fight against Gadfly Diseases in Animals (Bor'ba s ovodovymi
boleznyami zhivotnykh , Moscow, 1957, 12 pages. Briefly describes the use of
DDT against gadflies.
Professor A.A.Kudryavtsev, The Raising of the Young of Agricultural Animals
(Vyrashchivaniye molodnyaka sel-skokhozyaystvennykh zhivotnykh , Moscow, 1957,
35 pages. Basic rules for successful raising of young livestock.
3. These publications may be treated as UNCLASSIFIED when detached from covering
report.
S-E-C-R-E-T
NOFORN
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TeMnepaTypa B03ayxa 8-10 rpaayCOB. 3aTeM
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
C 15---20-JlneB1loro B03paCTa TCJIIIT BblpaLgR-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
oKOra: I114Tb1 AJmiioi 1,25-1,5 McTpa ;Lag ycTpOICTBa KJI TOK H
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
,i,cBaTb B CbtaopoTKe- KpOBH 6oJ1bHbiX HLIBOTHbIX coAep KaF1th
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Co8jni e i!e jiact!op Ka ,xtlst, c~ ep cat~He n ucl six i~ i~o~ e t
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CO2ILP*AHM9
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ABTopbM: AJnexcaHAp AneKCeeBHq KyapRoLee,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TBOpeHHH H COCTaBHTb npH6JIH3HTeJIbHbIH KaJIenJLapHbll3 rpa-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
f O k4eH,HOMy &JCTpee nPHCIIOCO6HTbCH K HOBOA 06CTA-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BaeTCSI, 3acbInaeT H JIHHIb H3pe,LKa HOHO.IIHT yinaMH ftpu
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
(c nOMOlljbIO KOTOpbIx rOToBSIT npocTOxBalny), He6J1aro-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
KOTOpble MO)KHO B03MeCTHTb nOBbIIIIeHHOI3 gagefi MOJI03nBa,
OCO6eHHO B nepBble AHH. B RaJlbHefiiueM, YTITH HI-IAH'BHAyaJib-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OAHH H3 Ba)KHeFimHx npfeMOB BbIpaLUHBAH>R MOAOAHHKA
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,IaCTO McHRIOT.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MHHepaJIbHas IIOAKOPMKa H AHeTHHeCKHe cpeAcma. Oc-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
O3HaKOMHTbC5I C peuerITOM H CTporo PYKOBOACTBOBaTbCSI
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16
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B03paCTy. rlpH 6oJlee OCTOPO}KHOM noaxoae MO}KHO noJty-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
A O,IA1oM 133 COBX030B YCCP HaMH 8bIJIO OOHapy*etto
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
tff#@ ff6f#eLH oefH K 13epexpefixHtlact 3aJulHe. I< KOHUy 6one3t1i
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3* 35
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ha6JIIo)ZaeTC5T Hc6JlaronpH9THOC cOoTH0nleHHe. Be3ycJIOBHO,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
O,aHH CHMHTOMbI HaAo yCHJIHTb, Apyrxe ocjia6HTb.
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
9TH 3a60JieBaHHSI MOT 6bITb H y geJlosexa H y x{HBOT-
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4* 51
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
a CTCJIbHble KOpOBbI, cyHOpocHble CBHHbH HpHXOJLcIT K COCTOSItl
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cTaTOX Hx y Mono) HSIKa Hapyinaem npaBnJn noe (JopMHpoaa-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIaMn (pTyT'HO-KBapueBble JlaMnbl). O6Jiytieuue yJlbTpaf Ho-
JIeTOBbIM CBeTOM He TOJIbKO }KHBOTHbIX, HO H HOKOTOpbIX KOp-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
roi - yclJIHBaTb Ten.iooTAagy npH neperpesaHHK. 3TO 3a-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
COACp>KaIIHCM I1 )HBOJj11T K CyXOCTH KO)KH, IIleJIyIHemno H
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yKa3aHHIO Bpaua JIeIIHTb.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ten.noi MbIJIbHOH BOAOH o6MbIBaIOT nopa}KeHHble ytIa-
CTKH, Hacyxo 06THpaIOT HX H 3,aTeM MO}KHO OCTaBHTb }KHBOT-
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BHyTpb AaIOT TaK}Ke XJIOPHCTbIH KaJIbIUHH B pacTBOpe H
Apyrne JleKapcTBa.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
06H3aHHOCTH BeTepHHapHOrO pa60THHKa - BbIHBJIeHHe
60JIbHbIX }KIIBOTHbIX, yCTaIIOBJIeHHe 3a60JIeBaHHH, BbIHCHeHHe
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIHTb 3a60JleBIIlee 3KHBOTH,Oe OT 3AOpOBbIX H npHCTyfHTh K
Oueuxe npH3HaKOB, XapaKTepH3YIOIL HX 3a60JreBaHHe.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
npHBHBOK, TO 3a60JICBaHHe nOCTeHeHHO nepeXOJIHT Ha 60JIb-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MODUbIO Jla6opaTOpnoro HcCJ1e,OBaHH51 HJIH noc ie 3a6oci
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
raHaMH ABH)KeIIH5T. BbICTpO pa3MII0}KaeTC5I B Te,ne }KHBOT-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
necepbe3nbIM onpaaAaHHeM ruioxoH pa60TbI yxax(HBatoutero
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BblpaxcaeTCSI B HepBHbIX Hpunaaxax, cyAoporax, 6oJIeBblx
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ha BHyTpeHHek noaepXHocTH 6eaep H oco6e1t1o Ha xbatte
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
fIpOTeKaeT OTieHb TA}KeJio, BbI3bIBa1 peaKu141O 14 yTiaCT146
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BHTb. Hen'pa'BHJIbHO noCTynalOT, IxorAa HanpaBJI511oT TOJIbKO
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5* 67
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B 3-He,eJIbHOM BO3paCTe H B 2-Mec gHOM. K KOHIZY TpeTbel'I He-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
a nopOC'HTa, HaxoJ !m'Hecsl MA Ka7KAoIi MaTKofl. 3a6o,n'e'BaIOT
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
fPHHHMaeT HOBOe nOJI03KeHH'e, H neTJIH KHHIOK Ile B03Bpa-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TOpbTX yTiaCTKaX HeT caBepuI,CHHO HOpMaJIbHOfI CJIH'3HCTOH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
6bITb H nOTOMy, LITO BIO B3pOCJI-OM COCTOSIHHH OHH HapaTHCioM
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HeH'HSI ,rtHaPH03a npH}Ka'3!HeHHbtM H'CCJIej(o'Ha'HIICM kpOHH
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
K KOJIH6auHJIJIe3aM OTHOCHTCSI OCTpble, ceHTWIeCKH npOTd-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
'rark t{ax KHIBOmH0i2 'a MOMellT o6Hapyx{eHnSi 3a6o.rl'eBa,t-tH5q
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
3a60JienaiIHe B03111KaeT TaK 6bICTpo, 'ITO TpyAHO TOLIHO
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
C 9T0ro M,OMCH"I'a HagHHaeTCSI ineCROnbKO ApyrOH ne;DHO/t
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}KHAKOCTb (3KcyAaT). flpH BbICJIyUIIIBaHHH TaK}Ke CnbIHIHbI
CyXHe XpHnbl.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
$ Haga.ne 6oJie3ltH yka3aanble nopa}t{ennx o6Hapyxcxsa-
IOTC5I B OAHOM JIevKOM, a B AaJibHexHleM npouecc MO}KeT
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
CyXOBaTbI, a JIIIM(~aTIIgeCKIJe y3JIbI OTCTgIIbl. JIHM(JaTHLIecKHe
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
3HaLIHTeJIbxo peace, a nOTOMy cpeAH MBCCOBbIX 3a6oJIeBaHHI%I
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIpH BCKpbITHH - MaCCOBble KpOBOH3JIHSIHHH, yBe1IHqeHHa5i
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HUM AeH"cTBHeM, a rIoTOMy, Bbl3Ba$tt i 3apa ceHiHe, Off I1HOP
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B TaKHX CJiytIarx 6e3 npoMeAJieHHH ROJI>KHa 6bITb npHMexexa
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B nemee BpeMSI c.neAyeT H36eraTb Bbinaca MOJIOAHHKa
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Xy,IjaHHe, cepbiI3 UBeT KO}KH, 38T51}KHOH KaIueJIb C 06HJIbHbA4
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BMOHHH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B 9TOI3 cTaj(HH ocJIOfKHeHHH cTF3paeTc 1 pamHUa > xim-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
mIBaHFie, neHHLxHJIJIHH, cy.lb43aMHAHbIe npenAp$TbI. iloJ3e3HOe
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
.H3eHTepHH HFHHT - dtgeHb rc KHorO BHHMaHHSI npe-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
napyitttioH o6o00ttKII, a Taiuke H $ttyrpH caMOro Bonoca.llpo-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cbti#UpoTka JjeIicTByeT 3ilatlllteJibIIO f blcTpee ii AepHee,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
,E e3:HH(~eKUHH nIpOBOAHTCSI 10-20-gnpoueHTHbmM ,pacTBo-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Hbrx. B 31HMHee iB'peMx rpbb3yiHbl TIacTO nOKH'AaIOT nacr6Hula
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
pBOTa, nOHOC; CnyCTH HeKOTOpOe BpeMSI nopOCRTa CTaiHo-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
KJIHHHtIeCKHe npotIHe npH3HaKH H 9HH3OOTH1 CCKOe pacnpo-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
-IeM paxblue BBOJUHTCH cbIBOpoTKa, TeM JIyqlue AeIiCTBHe.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
flpe1 HcaoBHe . . . . . . . . . . . . . . . . . . . . . . . .
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I p. 90 K.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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HOTOpOH yXOAFIT B MHOrOBeKOBOII HapOAHbMIi OIIbIT 6opb6bl c BIIH300-
TIIHMH CpeAH CeJi6CKOXO3nHCTBeHHLIX fIBOTH}JX.
HapnAy C aIIH300TOJI0rHeII H3y9eHFI M BOIIpOCOB, OTHOCJIIUHXCFI
K 3apa3HbiM 6oJIe3HHM, 3aHIIMaeTCH TeCHO CB93aHHafl C Hell MIIKpO-
6HoJiorHR. 3Ta MOJIOAaH Hayia B03HHKJla B cepeAIIHe upomJioro BeHa
H C Tex nop 6ypno pa3BHBaeTCn. MIIKpo6II0JIorln n3yilaeT HpHiIIIHy
aapa3Hblx 60JIe3HeI3 - Hx Bo36yAHTeJIefi - MHKpo6oB, OTHOCHHWHXCFI
1? 3
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
V Miipy HeBIIJjIIMbIX HeBOOpyMeHHbIM ma3oM MHHpoc1 OHHtICCIilX
Cy11[CCIB. IIoiIaj[a11 B OpraHH3M ?ICIIBOTHOFO pa3JlH'IIbIMII HyTHMH,
pa3MHO?HaHCb B HOM H HpOj[yH;HpyR F1 OBMTbIC BOH[OCTBa, OHM BbI3bIBaIOT
CO CTOpOHLI OpraHH3Ma OTBOTHyIO peaIl[HIO, HpOHBJIRIOII[y1OCR ero
6OJle3HCBHbIM COCTORHMOM.
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60B, ?H H3H0j[ORTCJIbHOCTb HOTOpbIX
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OTHOCRIIUHeCR 1f HporBJIeiIilIo 3apa3-
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HaBJIHBaJIHCb HCHOTOpb10 3aHOHOMOpHOCTH TegeHIM 3HH300THM H HaHaH-
JIHBaJICR OrpOMHbIH OIILIT 60pb6bI C 3apa3HbIMH 60JIe3HRMH. Oj[HaHo
B I[efE1 Ha6JHOReHHH HO XBaTaJIO BCCbMa CYIJ OCTBOHHOrO 3BOHa -
TO1HOFO 3HaHHR HpH911Hb1 3THX 605e3H0M - 14X B036yj[HT0JI0H.
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HpH'HH0Ii rHHeH11H II 6po?HeHH1J, Ha6Jnoj[aeMblx B Hp1IpOJ[e, RBJIRIOTCR
OIlpej[eJIeHHb1e MHHpoopraHH3Mbl. CB011MH j[aJIbHe1HIhIMH pa60TaMH
OH j[OHa3aJi pOJIb MHHpo60B B B03HHHHOBeHH14 HOHOTOpbIX CH0911(11-
9eCHHX 60Jle3HeIl 9eJi0BeHa H ?HHBOTHBIX H BO3MO?HHOCTb yCHOHIHOH
6opi,6b1 C HIIMH, HanpnMep c CH6HpCHOH R3BOM, pO?HeJ CBHHOH, 6eH1eH-
CTBOM M AP., HyTOM HpHMCHOHHR HpellapaTOB H3 oc ia6JIeHHiIX pa3-
JI119HbIMII cuoco6aMH HyJlbTyp - B036yj[HTOJIel HOpO'HCJIEHHbIX
60JIe3Heu. Tan HORBHJIaCb HOBan HayHa - MHHpo6HOJIorIIR.
B HOCJIelaCTepOBCHHII HOplOj[, HOCMOTp1 Ha ero HCHpOj[OJ1?KHTeJIb-
HOCTb (80-90 aeT), B 06JIaCTH 113y'eHII2 3apa3Hbix 60JI03He1 Cj[eJiaH
6bIJI p};[ OTHpbITHM OrpOMHOH Ba?HHOCT1i H caMoe rnIaBlioe - HOj[Be-
j[eHa Hay9HaR 6a3a, HOTOpaH IIOMor.Ia o60CHOBaib HaHOHJIOHHbIH
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BTOpOH 3TaH B H3y'eHHH 3apa3HbIX 60JIe3He1, XapaHTepH3yIOH[HI3CH
6bICTpuIM H BCCbMa yCHeIHHbIM HpO) BH?HCHHCM BHepej[ B pa3JTHPiHbIX
o6JIaCTRX 3HH300TOJIOFHH H MMHpo6HoaorlM.
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HRX IMJIO HapaJIJleJibHO pa3BHTHIO TCXHHHH H HpOMLIIHJIOHHOCTII 11
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
o6n3aHO pOCTy HoCJIeAHHX. AO cHx nop He CYWOCTBOBaJIO 6bI HayLIHbMx
npeACTaBJIeHHH 0 B036yJjIHTeJIAX 3apa3HbIX HB(CKIjnOBHb1X 6oTIe3HeI3,
eCJIn 6b1 6JiaroAapn pa3BHTHIO TeXHHHH He 6bIJI H306peTeH MHKpOCHOII.
IIOHBJIeHHO MHHpocHOIIa OTHOCHTCH H Haiia.iy XVII BeHa; nepBOe
onncaHne MHHpoOpraHH3MOB AaHO AHTOHOM JleBeHryHOM, HOTOpbIII
CHOxCTpyHpOBaJI npH6op, AaIOIUHH yBe3IHileHne B 300 pa3. JleBCHrylfy,
HccJIeAoBaBH1eMy pa3JIH'IHble o6'beHTbI - B0Ay, 3y6HOI3 HaJIeT, pa3-
JIHLIHble HacTOH, HCHpaHfneHHH H
AP., - OTHPLIJICH HOBbIH MHp paHee
HeBHAHMbIX cyujeCTB. JIeBeHryl{ BII-
AeJI MHHpo60B pa3HOH (OpMbl if
onHca.l HX?B cBoel pa60Te, Ha3BaH-
Hor3 opMbi nnouonoIBeaxx y pa3:1n'HIb)x rp116oB:
a - Penicilliuin; 6 - Aspergillus; s - Mucor.
He6oJlbIHHMH, IIJIOTHbIMH, BpaCTaIoll HMH B cpeAy HOJIOHIIFIMH. OHM
pa3BIIBa1OTCH HPH TeMHepaType 25-30?; HaTOreHHble BMAbI HY?KAaIOTCFI
Alin cBoero pa3BHTIIH B 6o.mee BmICoHOii TeMHepaType (37-40?).
H CeMeiICTBy Actinomycetales OTHOCHTCH TaR?Ke MHKo6aHTepnH;
HHTCBHJ1;HbII3 MHI JI1H Y HHX He o6pa3yOTCH, H BOA MHHPOCHOIIOM OHM
IIpeACTaBJIHIOTCR B BnAe najiogeM (HanplMep, BO36YAHTeJIH Ty6ep-
xyJle3a - Mycobacterium tuberculosis ii napaTy6epKyJie3a - Myco-
bacterium paratuberculosis).
ll_lHpoHO pacnpOCTpaHeHHbIMM B IIPHpOAe rpn6aMH HBJIHIOTCH
n ji e c e .H H (rH(oMHgeTbI), gaCTO BCTpe9aIou neCH Ha pa3JIHIHbIX
Cy6CTpaTax (Ha CMIPbIX npeAMeTax, B ChIPbIX HOMeII[eHHHX Ha KO?Kax,
rnrIIjeBbIX npOAyHTax, paCTeHHHx, Bapenbe M T. A.). Ppu6HMI[a, win
MnIreJIuH, IIJIeCeHH COCTOHT 113 rFi )0B (yAJIHHeHHble HIITH). MHHOJIHH
MO?KCT 6bITb CCIITIIpOBaHHbIM, I. C. pa3/(eJI0HHbIM llepeVOpOA{faMll Ha
2' 19
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OTj(e3I.H161e HJICTHH, HJIH HpO CTaBJIHTb C060H OJjHy ifJICTHy (y HH3IHHX
IIJIeCeHel). Y HJ10CeHei paajrn aIOT JjBa cnoco6a pa3MHOHfeHHH:
1) BereTaTHBHbIH, 3aujjio IaJoWHl3CH B pacraJje MHI[e3IHH Ha OTJjeJIbHMIe
( parMeHTbl (OHHjiiH, XJIaMHJjocropbl), JjaIOHI;HO B ZjaJIbHe1IHCM HOBb111
POCT MHII;eJIHIJ, HJIH B ()OpMHpOBaHHH CHOP-HOHHJ[ii, IIOHBJIHIOII;HXCH
Ha HOHIjax r1()OB - HOHHjjIICHOCB;aX H OTI11HYPOBbIBaloWu1XCH OT HHX;
2) HOJIOBOI7, HacTynaIomui HOCJIC LIepeJjOBaHHIH pnJja 6ecrIoJlblx pa3-
MHOIHCH14H.
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JjHTCJIH cTpnryn erO JIHIHaa H IIapIHH y geJIOBeia H Hf11BOTHL1X.
H LIHCJIy Ha[160JIee pacllpoCTpaxexxbix oTHOCHTCH: r 0 J1 0 B q a-
T a q II JI C C C H b (Mucor), XopoHlo pa 3BHBa10I1jafCfl Ha BJIa}HHLIx
HpegMeTax, CTCHax OTCbIpeBIHHX HOMeIIjeHHil, BJ1aHfxbIx HopMax H Jjp.,
H14 CT0B11Jjii aii HJIeceH b (PelnicllliUm), HOHHJj1eHOCIjbI
ee HMCIOT BRA HHCTH; H3 HOHOTOpbIX BIIJjOB 3TOH HJIOCeHH IIOJIyL1a1OT
allTH6H0THH HeHHIjHJIJIHH; JI 0 e T1 H a H II JI e C C H b (Aspergil-
lUS), cpeJjH HOTOpOYI BCTpeiIal0TCJT HaTOICHHbIC BHJ[bl (aclleprHJIJle3
IITHII).
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Blastomycetes) - OJ[HOHJIeTOLIHble OBaJIbHble HJIH HpyrJlble o6pa3o-
BaHHJI. Pa3MHO)HaIOTCIi OHH HoLIHOBaHHCM; HpH 3TOM Ha IIOBCPXHOCTH
JjpOHfHfeBOH HJIeTIfH IIOHBJIIIeTCI1 IIOCTCHeHHO yBeJIIHL11iBaiomHI4Cf1
BbICTyH; B HOCJICJjHHH IIOPCXOJjHT MaTepHHCHaf1 I1HTOHJIa3Ma H HJjepHoe
BCHjeCTBO. B JjaJlbHeRiueM OTIHHypOBbIBaCTCH BHOBb o6pa3oBaHHaH
HJICTHa H Ha'IHHaeTCH ee caMOCTOHTeJIbHO0 CynjeCTBOBaHHe. MHorm
BHJjbI Jjpommeii pa3MH0?Ha1OTCH CIIOpaMH.
HeHOTOpJIe JjpOHfHfH HcIIOJIb3y1OTCH HpH CHHpTOBOM 6po5HeHHH,
HpIiroTOBJIeHHH TeCTa, He(Hpa. OTJjeJlbHble B1IJjm Jjpow?1fei HaTOreHHbl
B036yJjHTeJIb 3HH300TIILICC1f0 0 J1IiM()a1rlTa JIomaJje1).
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
r.'aea III
DH3HOJIOrHfi MHI{POBOB
HHTaHHe MHxgO6OB. IITO6II OTHpaBJIHTb }HII3HCHHbI0 ~yHH1(HII,
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CTOHHHIiII1 06MeH BeWeCTB C oupyxtaioutell er0 BHellHeII cpeAog. He
BpeACTaBJIBIOT B 3TOM OTHOIIIeHHH HCHJIIOYeHHfi H MHKpoopraHH3MMI.
B COCTaB MIIi'p06HOI3 HneTKH BXOAHT B 6oJIbIIIOM KOnngeCTBe BOAa
(75-85%); B CyXOM BemecTBe ee HMeIOTCfi T3H Ha3bIBaeMble oprauo-
reHbl: yriiepoA (C - go 50% K C XOMy BeIgeCTBy), a30T (N - AO
12%), Bo)opoA (H - go 7%) H KHCnopo) (0 -go 30,5%). 3TH 3Jie-
McHTbI fIBnfHHOTC$I He06XOAIIMbIMII, Tax HaK 6e3 HHX HeBO3MO}KeH
CHHTe3 6eJIKa HaK OCHOBHOPO H{H3HCHHO Ba?HHOI'O BeLI eCTBa. HonII-
aeCTBO 6eni'a B CyXOM Beu[ecTBe AocTHraeT 50-70%.
HOMHMO Bepeii1cneHHJIX 3neMeHTOB, B HneTKe HMeIOTCH c 040p,
KanHI3, MarHIIII, cepa, } Hene30, HanbIZlll, HaTpnl, XTIOp, B HIIiITO}K-
HIiIX HOJIHLIOCTBaX HHor)a McAb, IUHHH, a TaKxce TaK Ha3EIBaeMble
pOCTOBbie BeigecTBa (( aKTOpu pocTa), IIrpaioLI IIe Cy1.1ecTBeHHy10 pOnb
B o6MeHe. 3TOT BecbMa MHoroo6pa3HbHI3 xHMHLIecHHI3 COCTaB 6aKTe-
pHI3H}IX HneTKK IIouOJ1HaeTCfl H3 oxpy}HaiomeI3 Hx CpeAbl, B KOTOpOI3
AOn}KHbl cOAep}KaTbCa BCe 3TH 3neMeHTbi. H 3TOMy CneAyeT A06aB11TL,
'ITO pa3n1iiHble BIIAbI MIIKpo6OB pa3H5ITC$I B TOR IInH HHOH CTeneHH
110 XIIMHLIeCHOMy COCTaBy II IIO3TOMy HpeAbfIBJIJIIOT H 3TOII cpeAe Aaneio
He OAHHaxOBble Tpe60BaHHfI.
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LIepe3 ee o6oao'IHy; lIepe3 Hee me II3 HneTKH BblAeJI nOTCfi HexyH(HbIO
ell OT6pOCLI. 3TOT o6MeH IIpOAyHTOB IIIITaHHfl II }KII3He)efITeabHOCTH
IIPOHCXOAHT 611aroAapa pa3HH1;e B OCMOTHPIeCKOM AasneHHII BHYTPII
H BHe 6aHTepHIIHOII HneTKH. O6bILIHo unTOIIna3Ma, BBHAy IIOCTOflHHOPO
BpHToHa BOAII, HaXOAHTCH B Ha6yxIIIOM COCTO}HH11 H TOCHO npuMbiKaeT
K o6ono'IKe. Tai' co3AaeTCfl oupeAeneHHoe Hanpr}HeHBe w14TOBna3Mbl,
Ha3hlBaeMoe TypropoM KneTKII, H coxpaxenHe elo CBOeI3 06b119110144IOpMIJ
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meHIIH HneTKII B rHIIepTonwIecKIIH paCTBOP CO1II Ha6juoAaeTCa BBne-
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Ha6yxaeT II TepAeT 4)OpMy. 14 B TOM II B ApyrOM Cnyqae 6aRTepir3Haa
KJlezxa MO}HeT IIorH6HyTb.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
HC06x0AIIMble AJIB II i'aH11H BCH[CCTI3a MIIHpo66bl HoT1 'I IOT 1,13
oI{py?KaioL[ eH CI)CA i pa3JII1911bIM1I IIyTHM11; 110 TI111y nlITaHIIB Hx J(eJIr1T
11a ABC. 60.11,111110 rpyiiHbl: ayTOTpo(()oB, I1JIri IIpOTOTpo(oB, if rCTepo-
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aMIIHOKIICJIOT.
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M0TaTp0O011, 11JIII cait poO11T0B, ?K11ByIIIIIX 3a C'ICT
MCpTBbIX opraHHIICCKHX BOIUccTB (I'HHJIOCTHble MIIHpo6bI), 11 n a p a-
T p 0 j) 0 B, 11CII0JIb3y10II[IIX AJJH I11MI11Tn ?KIIBOII 6CJ1oI , IIapa311-
T11pyI1 B HKIIBbIX TJ alIlJx 3KIIBOTHb1X 11 paCTCHIIII. B036yAIITCJIII 14H(feIC-
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Tp0(J)013, B TIa0TIIOCTII CaXapa, AIIIOrOaTOMHbIC cnHpTbi. I4CTOz1HIIIlaMH
a3oia )JBJIB10T01 aTMOC(epHbIii a30T, 6eJIKOBbIC BCIITCCTBa (upl HX
paculcimeIIH11), OTACJIbIibie aMIIHOKIICJIOTbI.
TaK11M 06pa30M, 6axTepuIIHar KJICTKa IIpeACTaBJ1fICT c060II H au
6bi npeKpacno opraHHaor3aIIHyIO XHMli 1CCKy1o Jra6opaTOpHlo, BOCIIp11-
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B HanIOpllllx; HanpnMep: OKIICJIHCMbIII IIpOAyKT + 110,-11POAyKT OK11-
ciieniIA + X KaJiopii i.
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a a p o 6 it bi e M II H p o 6 bI (aapo6bi), HC110Jlb3yl01IIC AJIH Ox11-
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1IbIX (JyHHIiHii, Ito Aaxee BpcuCH (o6JlnraTHbl(,' aHaapo6bl). TaIIIM o6pa-
30M, pa3rpaHll`[CHiI McHCAy aapo6aMH if aHaapo6aMH OTHOCIITCJILH0
yCJIOBHbI.
3ii3IIMbI MIIKpO6OB. XIIMII'ICCKHC npOlTecebl, IIpOHCx0AIIIIU11e B M11K-
po611bix KJIeTRaX, a TauaKe B OICpy?KaIomcii epeAe HoA 11X BJIHHHIICM,
o6ydnOBJ111MI10TCII IIa1nuIIeI Oc06bIX BCH1;CCTB - 3H3IIMOB, HJIII (J)ep-
MCHTOB. 3H3IlMbI IIrpalo'r pOJlb Ka'raJIII3a'rOpOB, B HpHCyTCTBIIII HOTOpUIX
CTllMyJIHpyIOT('31 paaJ1Il'1IJb1c x11MI1'icciillc peaK Aim. (I)epMCHTbI Cne-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIII(Im"IHbI H Hpolln IFIIOT CBOII CBOIICTBa JIHITIb B OTHOIHCHFIII oupeAe.1eH-
HbIX XHMHMOCHIIX npOIJeCCOB; OHH HeyCTOHLIHBbI HO MHOI'1M BHCIIIHHM
B03AeI3CTBHf1M 11 pa3pyuIaIOTCH np1 HLICOI{oI1 TeMHepaType, B HpHCyT-
CTBHH IUOJlogej, KHCJIOT, COJIeH TH]ISOJIbIX McIa;IJ10B. Pa3JI1PIaIOT
3 IC T 0 3 H 3 IT M bi, BbIJJeJIHeMble MHICpO6aMH B HHTaTCJIbHyIO CpeAy,
paCTBOpHMIIO B H013 H IIPOXOAAHUIIC tIepe3 6aHTep11II1TbI3' (JlnJmTpBI,
11 3 11 A 0 3 H 3 H M 161, TCCIIO cB113anHbie C TOJIOM ICJICTICII 11 oCB06o1ICAalo-
fuHecn JIHHIb HpH ee paCnage. HpH HOMO1]1 OH311MOB COBepIuaIOTCH
TaH1l XHMHTICCKHe peaKuuH, HaH rtigpaTau m H J);CrnApaTauHA (c Hp11-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I'.aaea IV
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
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no Mop(oUorHLIecnHM, ( IH3HOJIOrHileCHHM, allTHreHHbIM H BHpyJIeHTHbIM
CBOHCTBaM. Y 6OJIbIIHHCTBa HaToreHHMIX MHnpo6OB THH S 6o.lee
BHpyJIeHTeH no cpaBHeHnTo C TIiIOM R. CH6ilpem3BeHHbmA MHHpo6
npeJjCTaBJIHeT B 3TOM OTHOIHeHHH HCHJIIO'IeHHe - y Hero THH R -
HaH6oJIee BHpyJIeHTHaH (JopMa, Talc Han 3TOT THH JjJIH cI6HpeH3BOHHOrO
MHnpo6a OCHOBHOII, a TIM S - H3MeHeHHIill.
CyMMHpyn JjaHHLIe, naCaIOHjlecTI H3MCH4HBOCTH MHnpO6OB, MOHTHO
cAcaaTb BMIBOJj, LITO 3Ta IIpo6JleMa, HMeTOI aT Cepbe3HOe TeOpeTMIe-
cnoe m HpanTHLIeCHOe 3HageHHe, eH(e JjaJlena OT OHOH'IaTeJIbHOPo
pa3pelIeHHH. OjjHalio OCIIOBHOC HOJIOHC0HHO O peuialoweM BJIHUHHH
YCJIOBHIi BHeIHHOH CpeJ[bI Ha H3MeHLIHBOCTb MHHpOOpraHH3MOB He
BbI3LIBaeT COMHCHHIi H BOJjTBCpmgaOTCH BCOMH JjaHHbIMH MHnp06H0-
JIOrHII. 3TO O6CTOHTOJIbCTBO JjaeT OCHOBaHHe paCCMTITbIBaTb Ha JjaJlb-
HeI3IHHe yCHeXH B IIOJlyLIeHHH IIyHCHbIX H 11OJIe3HbIX JIJIH WJIOBOHa
BHJjOB 6anTepIH IIpIIMCIICHIICM MCTOJjOB HaIIpaBJIOHHOH 143MOHLIHBOCTH
Mllnpo6oB.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
rnaea V
MHHPOBbI H BHEIIIHHH CPEJIA
BinixHne 4)H3HileeKHX (IaITOPoB. F 41H3HMecKHM (aRTOpaM, oHa-
3bIBaIOH[HM BIapamOHHOe B TOH HJIH HHOH CTeueHH B03AefCT13He Ha
H(g3HeAegTeJTbHOCTb MHKpo6oB, OTHOCHTCH: TeMIIepaTypa, BbICymJIBa-
HHe, AaBJIeHHe, ABHmeHHe, cBeT, 3JIeKTp1ileCTBO, JIy'in PeHTreHa H
paAHH.
T e m H e p a T y p a. Pa3HNIe BHAbi MHKpoopraHH3MOB HeOAH-
HaKOBO OTHOCHTCH H KoJIe6anIuJM TeMHepaTypbl OKpyxcaiou eA cpeAbl.
rCanpo()HTbI 60Jlee HpHduoco6JleHM H H3MeaeHHHM BHeHIHeg TeMnepa-
TyPII HO CpaBHeHHIO C IIaTOreHHbIMH MHKpo6aMH, HpHBHKHIHMH K TCM-
nepaType xo3RHHa, B HOTOpOM OHH IIapa3HTHpyIOT. HH3KHe TeMHepa-
TypbI McHee BpeAOHOCHnI AJI$I MHKpo6oB 11 o6blqHo HX KoxcepBHpyloT,
HepeBOAFI B aHa6HOTH*iecxoe cocTonHHe, B TO BpeMFI KaH BbICOHHe TeM-
HepaTypbl ry6HTeJlbxbl Aim MHKpoopraHH3MOB.
PaccMaTpHBaa BJIHAHHe TeMHepaTypnoro ( aHTopa, MOH(HO.OTMe-
THTb cyII(eCTBOBaHHe TpeX TeMIIepaTypHbIX 30H: OIITHMaJIbHOH - HaH-
60JIee COOTBeTCTByIOH[wx3 npOHBJIeHHIO HfH3HeAeHTeJibHOCTH MHKpo6oB;
MHHHMaabHOI - HpeACTaBJIMoigeii co6ou npe)ell, H1 Ee HOTOPOrO
pa3BHTHe MHKpo6OB HeBO3MOH{HO; MaI{CHMaJIbHOII - c1lynCaITZeH nopo-
rOM, HpH HOTOPOM AaJIbHeHmee IIOBhImeHHe TeMIIepaTypbl ry6HTeJIbHO
AJIH MHKpo60B. Tan, Hanpnrep, AJIH B. tuberculosis cocTaBJIHIOT:
MHHHMyM 29?, OIITHMyM 37-38?, MaKCHMyM 41?; AJin B. anthracis:
MHHHMyM 12?, OIITHMyM 32-37?, MaKCHMyM 45?; in B. mallei:
MHHHMyM 20?, OHTHMyM 37-38?, MancHMyM 44?; Aim B. subtilis:
MHHHMyM 50, MaKCHMyM 57?. TaKHM o6pa30M, aMnJIHTyAa noJie6aHHH
Me)KAy MHHHMyMOM H MaRCHMyMOM y IIarorenHbix MHHpo60B 3HaLIH-
TeJIbHO McHbrue, tleM y CaIIpO(HTOB (B. subtilis).
NO OTHOIIIeHHIO K TeMIIepaType pa3JTHLIaIOT TPH rpyIIIIb1 MHKp06OB:
ii c H x p 0 (i H JT b H bl X- IIpHcuoco6JIeHHblx H MH3HH IIpH xOJIOA-
HBIX TeMIIepaTypax; HeHOTOpBIe BHAbI 3THX MHHpo60B MOryT pa3BH-
BaTbCH game IIpH OTpH aTeJIbHOH TeMIIepaType; M e 3 0 chi H JI b-
H bI x - HaH6oJlee MHorogHcJIeHHh'x cpeAH ApyrHx rpynu 6anTepHg;
B Hee BXOAHT TaHme HaToreHHbie MHHpo6LT; OIITHMyM Ann Me30(HJIOB
IIpeACTaBJIHIOT 30-37?, MIIHHMyM 10? H MancHMyM 45?; T e p m 0-
( H JI b H bI X - pa3BHBaIOII(HXCH IIpH cpaBHHTe3IbHO BBICOKHX TOM-
HepaTypax: IIpH MHHHMyMe 0HOJIO 35?, 0IITHMyMe 50-60? H
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MyMe 70-80?. Pa3BnTHe TCpMO(f uJIOB B HaBo e COHponoHlAaeTCH
noB1,1111CBHeM B nCM TCMnepaTypbl go 60-70?; B ATOM npoi ecce npH-
HnMaIOT ygacTI3e TepMOrCHHble MHI;p06LI.
Pa3JI1414HOC OTHOIITCHIIC I; TeMnepaType npOHBJIHIOT BereTaTHBHble
(IopMbI MITI{po6oB H nX CHOpbl. Tart, HarIpHMep, CHOpb1 Bo36yJTHTejIH
C116111CKOH H3BbI OCTaIOTCH HU4311eCIIoco6HbIMH HOCJIC 15-MHHyTHOP0
HnnF'loll tiff, CH(OpbI CTOJ16IIHMHOH IIaJIo 1lH - nocrn 3-MaCOBOI'O HHnH-
MCHHH, TOFAa I;aH IiX BCI'eTaTHBHbIC (J)opMbl HOrH6aJOT BpH TeM1ICpa-
Type 70-80?.
B bi c y fit H B a it n e BJIetIeT 3a co60H HOTepiO BOAbI, a BMCCTe
C TOM rH6eJIb MliKpo6oB, TaR HaK BOAa COCTaBJIHeT CyIL eCTBeHHyIo
MaCTI, MHHpo6H07I HJICTHH. HaH6owiee iIyBCTBHTeJIbHbI H BbICynIHBa-
HHIO HCCnopoo6pa3yloI ilie MHKpO6bI H BerCTaTHBHbIC (J)OpM1iI CHOpO-
o6pa3yI0MHX. CHOpbI BCCbMa yCTOHMHBbI H 3TOMy (JaRTOpy B03AenCT-
13111 H MOT coxpaBHTbCH B CyXOM COCTOIIHITII AeefITHJIeTIIu1M11. libICTpO
rH6HyT npli BblcynhHBaHHl carllloff MHICpo6, B036ygHTeJ1b reMopparH-
MOCHOjI CCHTHIIdMHn, B TO BPCMIT xaif Ty6epi;yJIe3Han HaJIOtIIla MObH T
CoxpaHHTbCH MCCHI1;aMn B BbICyIBCBHOH MOHpoTe. E03AefCTBne BbICy-
InHBaBHCM MO?KCT IIJBMCHHTbCH AJIH o6e33apa?KHBaHIIH pa3JIH1IIIbIX
cy6CTpaTOB, co ep?Kan[HX naToreHllblx MHHpo6oB, H AJIH HoHCepBH-
pOBaHrIH CHOpoBOpTHHJHXCH BpoAyHTOB.
R a B it e H It e Aa?HC B COTHH H TbICHMH aTMoc(J)ep He oHa3iaBaeT
BpeAHOrO BJIHHHI111 Ha ?Hn3HCAeHTeJ1bHOCTb MHHpo60B.
A B B ?T; e H If e B Bile MexaHWICCUOrO COTpHCeHHH, HanpHMep
ABBHieHne BOAbI B Te13yilnX Bo oeMax, y6HBaeT MHI;po60B. QHH TaK?KC
6biCTpO ru61TyT ITpii BCTpnxliBaJnn ?HHAKOCTII, B HOTOpOH OHH B3Be-
ITICHbI, B OCO6eHITOCTIi CCJIH K B3BCCH Ao6aBHTb neCOH ruin CTeKJIHHnble
6yCLI. 3TIIM BpndMOM MaCTO ITOJ1b3ylOTCH B JIa6OpaTOpHOH npaHTnHe,
IIpHMCHH}1 HIyTTCJIb-arlnapaTbl (I1pO113BOAHT AJIHTCJIbHOe BCTpfIXHBa-
Bile B3Bedi1 MIIKpo6oB).
H p u M 0 ii C 0 JI 11 e q H bl fl CBOT y6HBaeT MHKpo6oB B epaB-
HIITeJIbHO HOpOTHIIC CpOKH (OT HeCHOJIbKnX MHHyT AO HCCIOJIbHIIX
MaCOB, peAKO Hecl;oJlbHHx CyTOK). Ero AehbCTBITe o6'bHCH9eTCH pa3BH-
THOM OTHOCHTCJ1bHO BMICOKON TOMnepaTypbI Ha o6JlyMaeMbTX npeAMe-
Tax, a riiallnblM o6pa30M 3J)(eI;TOM yJlbTpa(HOJIeTOBbIX JIyMeH COJIHeM-
Boro CBCKTpa. PacceaiBHbIIi COJIHCMBLIA CBOT 3Hag14TCJILHO MCHCC ry6H-
TeJICH AJ111 Mrihp060B.
B CB9314 C BbICOI;OH 6axTep1Ir nAHOCTLTO yJIbTpa(HOJIeTOBbIX JIytICH
o6JIyMelne IlMH ?HHBOT}IQBOAgdCHHX noMebIIeHHI3 AOBOJIbHO M1POHO
IIpIMeHHCTCH B BpanTHHe ?HHBOTHOBOACTBa (KBapueBbie 11 yJIbTpa-
BHOJIeBble JIaMnbI).
DabTepHrJvI noCTI, npfIMOrO COJIHOMHOro CBeTa AoHa3blBaeTCH KJraC-
CHMCCHHM OnMITOM. B LialnEy HeTpH C arapOM 3aCeBaloT KaKOH-JIH6o
MHHp06 H 3aHpbIBabOT ee MepHOI3 CBeTOHenpoHnr aeMOH 6yiarol3
C Bblpe3aHHbIMn B Held OTBOpCTHHMH, 6yHBaMH wild IjeJIbIMld CJIOBaMn.
ilanTHy O6JIy ialOT npfIMbIMH COJIHeMHbIMH JIyMaMn 1-2 qaca if HOCJIe
3TOrO BOMelUalOT B TepMOCTaT. Llepe3 CyTHH pOCT lyJIbTypbI MOH HO
OTMOTHTb JIHIIIb B 3aTeHeBHbIX MCCTax.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIytiH PeHTreHa II paAHH BMaJIblx go3axCTnMyTIH-
pyIOT pOCT MuHpo6OB, a B 60JlbllHx (IIpn AJIHTOJIbHOH 3KCHO3IIBHH)
OHa3JIBaIOTCH ry6HTeJlbHiIMH.
3 JI e K T p H iI e C H H A T 0 K HpOHBJIHeT BecbMa CJIa6oe 6aKTe-
pII9IIAHOe AeiICTBile.
BAHHHHe xHMll4ecHHx I aKTOpOB. BoaJ eI3cTBHe xlMHilecHHx Be-
IIjeCTB Ha MHKpo6oB 3aBII04T OT HX xapaITepa, Aoabl H AJIHTenb-
HOCTH 3KCn03HIAHH. Mailbie A03bI HeJOTOpbIX XHMIPIecHnx Be-
HgeCTB npH KpaTKOBpeMeHHOH 3KClIO3119IIII MOryT CTHMyJIHpOBaTb
pOCT 6ai{TeplHI, a 6OJIblh11e A03bI - y6HBaTb MHKpo6oB. XHMHgecKHe
Ben;eCTBa MOryT oKa3aTbCH ry6HTeJlbHbIMl3,
BbI3hIBan B 6aRTepli3HOI3 KJIeTKe OKIICJIII-
TOJIbHble (HHCJIOTM, MapraHAOBOKIICJIbIH Ha-
JIHH, XJIOpHa} H3BeCTb) IIJIII BOCCTaHOBHTeJIb-
Hbie ((opMannH) IIpoliecCbl, a Tai1Ke Koary-
JIHI;HIo 6eJIHOB. Pa3Hble BIIAbI MHKpo60B
npOHBJIHIOT HeOAKHaxdBylo yCTOYIiIHBOCTb H
XHMHLIeCHHM BeiiAeCTBaM; Ha16oJIbman 3KCIIO-
3III]HH Bo3AefCTBHH H IIOBbIHIeHHan HoHgeH-
Tpa11HH BeJIWCTBa B pacTBOpe Tpe6yeTCH
JJ;JIH TOM, qTO6hI y6HTb cnopbl, Tax, Bere-
TaTIIBHble ~OpMbI CII611pen3BeHHOrO MIIKpO-
6a Horl6aloT B 5-IlpoAwHTHOM paCTBOpe
Kap60JIOBOA KHCJIOTbI uepe3 HCCHOJIbHO MII-
PHc. 7. JjeI1cTBHe coa-
He4IHOro cBeTa Ha Hyab-
Typy - pOCT allIIIb B aa-
ApbITbIX OT cBeTa McCTaX.
HyT, a cnopbi 3TOPO MHKpo6a Jlnuib *Iepe3
14-40 CyTOK. AynrunM paCTBOpnTeJIeM XHMII'qeCKHX BeWeCTB, B
HOTOpOM 0HH oHa3bMHaIOT HaH6oJIee BblpaHieHHylo 6aHTepnAIIAHOCTb,
HBJIHeTCH BoAa, Tax HaH B BOAHbIX paCTHopax IIpOHCXOAIIT Hx
Hal6owlee 3HeprnnHa1 AIICCoUIIaI IIH Ha H- ii OH-HOHM, tiTO onpeAe-
JIHeT peaRiAmo (pH) epeAbl.
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JKaeTCH B CHJIbxeMIIrel3 CTeneHH Ha H 113HeAeHTeJlbHOCTH 6aHTepIIFI.
RJIH naToreHHbrx MHKpo60B Han6OJIee 6JlaronpnHTHa HelITpaJlbnaR HJB4
CJIa6o a eJiogHan cpeAa (pH=7,0-7,6); oTKJIOHenne pH B CTOpOHY
KHCJIOTHOCTII IIJIII II10JIOLIHOCTH MOHSeT TOpM03HTb MH3HeAeHTeJIbHOCTb
MIIKpo6oB.
B HpaHTIIH0 np0(IIJIaHTnHH H 6opb6bl c 3apa3HbIMH 60Jle3HHMH
CeJIbCHOX03HIICTBeHHbIX HCIIBOTHUX IIpHMeHHIOTCH pa3JIHLIHbie upneMbl,
IIpHBOAH He H rII6eJIH MHHpo60B.
C T e p n JI II 3 a it II H IIMeeT AOJlbro yHHLITO?Kenne BCeII MIIHpO-
( J[Opbr B AaHHOg epeAe II Ha pa3JI1P3Hbix npeAMeTax. A,oCTnraeTCH oHa
o6HCnranneM IIOBepXHOCTeII npeAMeTOB, Himq enneM, o6pa6oTKOri
TeHyiIIIM IIapoM H aBToJJlaBnpoBaHHeM. H cTepIIJrn3ai[iH HpH6eraloT
B 6aHTepHOJIOrIILIeCHOr3 n xHpyprlI ecHoiL npaHTITHe, Hor a Tpe6yeTCH
IIOJMOCTbIO 06edIIJIOAIITb IIHTaTeJIbHble cpeAbl, o6e33apa3IITb HHCTpy-
McHTapHA, pyHH xnpypra, oliepaluHoHHoe noJle.
A H T 11 C e II T H K a (B XIIpyprHH) 3aHJIIOLIaeTCH B yxnirTO?KeHnl
pa3JIIi'iHb4MII XIIMIi` eCW MI BenjeITBaMU MuKpo60B B paaax; a c e H-
1
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
T H H a HMeeT i eJibio npeAoTBpaMOHHe nonaaaunn MHHpo6oB B
paImx.
e 3 H H( e H g IT H CTaBIT nepeA co6oi3 3agwiy yHH'gTOHfeHHH
naToreHHbIX MHHpo60B, HMeI01gnxc 1 BO BHOIHHOH cpeAe, OHa IIpeA-
CTaBJIfIeT Co6oii AOBOJILHO CJIO}HHyI0 CHCTeMy MeponpHHTHiI, nrpalo-
IAHX BCCbMa CyWeCTBeHHyIO pOJIb B npOcJnJlaHTHHe H JIIIHBIIAaIAnn,
I1IH eHIInOHHbIx 6o.Ie3HeI3 (CM. rJlaBy (1,Le3lHi lexgffm)).
BJinfiiiie 61IOJ1orniieenux 4IauTOpoB. BogBa, Boaa H BcR oHpyxcaio-
igafi BHemHHn epeaa LIpe3BblLIaiiHo 6oraTbl pa3 iu inOI3 MHHpoi3JIOpOi3,
OTJZeJIbxble DHABI HOT0poi3 yLIacTByIOT B IlpeBpaweHHn BeJ CCTB B npn-
poae. TaHHM o6pa3oM, B 0TACJIbHbIX Cy6CTpaTax BHOIHHOH cpeAbi
B pe3yJIbTaTe 3BOJIIOA14R MHHp06Horo MHpa, BbIHCHBaHHn OAHHX B1AOB
H rH6eJIH HenpnCH000611BHI1-IXCFi co3aaeiCH MHHp06HbIii Hef33axc -
accoUIIaIuIH (6Hoi eHO3) M11Hp060B, HOTOpbIM B 3HagHTCJIbHOn Mepe
OnpeAeJIHeTCH BO3MO}IfHOCTb npOHBJIeHnH pa3JI11LIHbIMn BHAaMH MHHpo-
6oB CBOeH }aII3HeAeHTeJIbHOCTn, TaHoe }HC nOJIO}HeHne Ha6JiioaaeTCH
B OpraHH3Me H{HBOTHOrO H LIejioBela. Oco6oe n3061JIne MHHpo-
tJ)JIOpbI OTMCLIaeTCH B HHHIegHIHe, B erO TOJICTOM oTAeJIe. B iioc ieA-
HOM npOTeHaiOT BeCbMa CJIOHSHble MIHpo6HOJIorngecHHe npo1 ecem,
BJIIFIIOMHe Ha paCII(emicif C IIHTaTeJIbHbIX BenJeCTB, H C03AaIOTCfi
pa3.TwgHbIC OTHOHICHHI MCHfJy OTAeJIbHbIM11 BnaaMH MHHpo60B,
B opraH113M EIIBOTHOrO MOFYT nonaaaTb TaH}He HaTOreHHbIC
MHHpo6bI, BCTpe=IaIon 1Te 3Aecb HaH 6JlaronpIHTHbie, TaH ii He6Jiaro-
IIpHnTHble yCJIOB149 AJIH CBOOi3 Hfn3H11, onpeaeJTHioigHe B03MOHCHOCTb
Hx AanbHeHH[0r0 CynjCCTBOBaHHH H npoHBJICHIIH napa3rITniiecHHX
CBOHCTB. H3BeCTHO, HanpHMep, LITO npn OAHOBpeMeHHOM HH()nI[npO-
BaHIIH OpraHH3Ma HaHHM-JIH6o naTOreHHbIM alaapo6oM (6ai[nJiuibl
CTOJI6IIHHa, 3JIOHaileCTBeHHOrO OTela HJIH 3MI H3eMaT03H0r0 Ifap6yH-
HyJia) H a3p06HbIM1I MHHp06aMH BO3HHHaIOT yCJIOBHH, CHO006CTByIO-
I4He nponBJIeHHIo aHaapo6HOiI HHIIeHIIHH, LITO MO}HHO TpaHTOBaTb HaH
CIM6H03 MHHpo6oB. Bo3Mo}HeH, Ilao6opoT, aHTaro-
H 11 3 M MHHpo6oB, Horaa B npHCyTCTB14H oaH0r0 BHAa HX, HanpHMep
HnlilegHOH naJIOLIHn, He pa3BHBaeTCH naTOrOHHbli3 MHHp06 - B036y-
AHTeJIb CH6HpCHOH FI3BbI. HHOrAa MaJIO naTOreHHble DHABI MHHpo6oB
aHTHBH3HpyIOTCFI 1OA B03AeiCTBneM HaHHX-JIH6o canpo HTOB (C 11 H e p-
r 113 M MHHpO60B).
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HnHOB OAHHM 113 nepBbIX OTHpbIJI CyII[CCTBOBaHHe B Mnpe MHHpo6oB
HBJICHHH aHTarOHn3Ma. HM 6bIJIo yCTaHOBJIeHO, LITO MOJIOLIHOHHCJHhIe
6aHTepln yrHeTaIOT }HH3HeAeHTeJIbHOCTb rHIJJOCTHbIX Mnxpo6oB,
Ha OCHOBaHHH 'IerO OH npeaJTO}HHJI 3aceJIRTb HHIIIetHHH iieJIOBeHa
I{yJlbTypHbIM1 pacaMn MOJIOLIHOHHCJIbIX MHHp060B, HOTOpMe AOJIxcHbI
6bIJIH nOaaBJIHTb AeHTeJIbHOCTI, rHHJIOCTHLIX MHHpo60B n TeM caMLIM
H36aBHTb JIIOAef OT IIOCTOHHHOrO OTpaBJTeHnnI TOHCHHaMH, BbIpa6aTbl-
BaeMbIMH 3THMHMlHpo6aMn. B HaCTOHH[ee BpeMH HBJieHHe aHTarOHn3Ma
IIHpOHO ICIIOJIb3yeTCH B IIpaHTnxe 60pb6bl c IIHI eHI1HOHHbIMH 60JIe3-
HFIMn MOJIOAHfiHa CeJIbCHOXO3HHCTBeH.HbIX H FIBOTHbIX (CHapMJIHBaHne
aI[ngoI aaHHa, BBeAeHHe aLHAo(HJIbHOH 6yJIbQHHOH HyJIbTypbI 13 T. A.).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HOJIOTe6HeB H MaHacceHH euie B CeMHAeCHTbIX max Hpomnoro
Bexa ycTaHOBHJIH, 'ITO rpH6 3e7IeHnII3 HHCTeBHH (HeHHIIHJIJIHyM) 3a9ep-
H{HBaeT pOCT HeHOTOpMx 6aHTepHH, a TapTaHoBeRni3 (1904 r.) BhIHBHJI
nege6Hoe 9eHCTBHe 3Toro rpl6a upH HacTepeJIJIe3e Hyp. Tax 6MnH
3aJIOH{exbI OCHOBBI yqeHHH o6 aHTH6HOTHLIeCHHX BeuiecTBax, Hni
aHTu6HOTHHax, HOTOpoe uoJIytIHJIO ullpoHoe pa3BHTHe B HaiueI3
cTpane n 3a py6ex{oM.
AHTH6HOTHHH - MOLUHOe CpO.1 CTBO B039eIHCTBHA Ha Bo36yAHTe-
neH paaJIwrnIJx IIH( IeHB;HOHHMX 60JIe3Hel. Y}He H3BOCTHbI AOCHTHH
aHTH6HOTHLIeCHHX BeuiecTB, MHOrHO H3 HOTOpMIX UIHpOHO HpHMe-
HfIIOTCII B HpaRTHHe JIOIeHHH
HH(eRILHOHHhIX 6oJIe3Hen LIe3I0- B. COL!
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3Ha'IHTeJlbxoe pacnpOCTpaxeHHe
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TO'IHOH aRTHBHOCTbIO, HIHpOHHM 9'ON000CCUS
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THHOB H3BeCTHL1 HeHHIUHnnHH, rpaMHIUHAHH, CHHTOMHUHH, 6HOMHUHH,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
H 0 H H I[ H JI JI H H - BeCbMa aRTHBHbIFI npenapaT, HCnOJIb-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
paCTBOp$ITh (JIH3RpOBaTb) OTJjeJIb13bie BITJ(bl MIIHp06OB. OH OHelJH(H-
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BaHHH ( HTOIIAIIAOB J;JIH JIeLIe6Hbix i eJIeI3 HIHpoHO UOCTaBJleubl B CCCP.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
l.aaaa VI
POJIb MHUPOBOB B IIPEBPAHIEHHHH BEII(ECTB
B HPI4PORE
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TCJIbHOCTbIO FHIJIOCTHUIX MIIHp060B. 3TOT IIpOrjeCC MOIHOT npOTeHaTf.
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rion septique, B. coli, Proteus vulgaris, B. subtilis - n MHorne Jjpyrne
ninpOKO pacnpocTpaHeHbr B npHpOJje; Hx HaxOJjHT B IIOMMBO, B03JjyXe,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
PyccHnl3 MlHpo6noTlor C. H. BHHOrpagcxHIi goHa3an, tITO MHorie
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60B, HpHCII0006JIeHHbIx yCJIOBIIBMH }K113Hn H THOU genTeJIbnocTH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B CCCP LII I OH( TIPHMOHHIOTCH pa3LLT'IHble 6aHT0pII iIIbIC rrpeHa-
paTbI (TIHTpaFHH, a3oTo6alTepliH) gJI3I o60raTUeHIIH Bo1IBb1 a3oTOM.
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HPHMCHHIOTCH ((HYJIbTypHbI0 Ap0HC?h1n).
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B npoueccax cnnp oBoro 6poxceHHH MOPyT IIPHHHMaTb ygaCTHe,
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cTpaTe, cogepxcaMeM He 6oriee 14? cIIHPTa, CCJIII ero OCTaBHTh OT-
HpfITbIM Ha B03Ayxe H B TerIJIe. TaH 06bi4Ho cHHCaIOT BHHOrpaAHble
BIIHa, npeBpan[aaCb B yr cyc. B nnieHHe, HOTOpasl o6pa3yeTCH Ha
IIOBePXHOCTH 6pogHruei3 HSHAHOCTH, HaxoAHTCH yHCycHOHHCJIbie 6aHTe-
pHH, HOTOpbIMH o6yCJIOBJIHBaeTCH yHa3aHHbIH npogece. CHallaJia
BbIpa6aTbIBaeTCH 11 OM0H{ TOIIHbIii II OAYHT - yHCyCHbIH aJlb)erlA
no ypaBHeHHIO: C2H6O + 02 C2H4O2 + H20; B HTOre Aajibueiimero
oHHCJIeHHtl noJIyqaeTCH yHCyc.
Mac JIHHoHHcJloe 6po5Henii e- pe3yJlbTaT pa3-
aomeHH1I pa3JIH1IHbrx opraHH IeCHHX BeII{eCTB IIPH B03Aei1CTBHn CIIe-
Iw4 wiecHHx anaapo6HbIx cnopoo6pa3ylo- AO
Iuux MHxpo6oB (Amylobacter), BOCbMa $oo P
1
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..,.. .... 1 . y 1 .... X10 0 0" 0
PacruelJieHHe yrJIeBO90B, a TaH1Ke mHPOB ?o0 0 O Uo0 ~~ O
H 6eJIH0B BegeT x 06pa30BaHHIO MaCJI
HHO
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an~ra_ n ri O o , IJU 0 rip
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yp
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xoI1 H gpyr1X HHCJIOT H HOI{OTOPbIX nn.OOOO0 I p o o II Q
xpo6oB HaXOAHTCJI B IIO1BO
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ycT0I3'IHBOCTH HX CHOP H BLIC0x OI3 TeMne- 0?0~ ~~~ o IINIIn,7j1\~,
O O A O" V
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e OHH Mn-- B1I3LIBaTb 1TI1TlM n a1i
p
yp
ce
nporperbix ripogyHTOB, IlanpHMep Hon-
cepBoB, C o6pa30BaHHeM ToxcHgecHHx
BenkecTB (B. botulinus).
PHC. 12. Yncycnoxxcnan
nanogxa.
M0JlogHOHHCJIOe 6p01xeHHe npHBOAHTxpacmenJle-
HHIO caxapoB (reHC03) Ha ABe gacTHgbl MOJIOgHOIT HHCJIOTbI 1110 ypaBHC-
HHIO: CBHI206 = 2C3H603. MowlogHoRHcJloe 6po]HeHHe AaBHO HCII0JIb-
3yeTCH geJiOBegeCTBOM AJIH IIpHrOTOBJieHHH IIpOCToRBami, HyMbIca,
allpaHa, pa3JIHxIHTiIX CbrpOB. OnpegeJleHHbiiI BHA CIIeIH( HgecHHX
MHHp060B - BHHOBHHHOB MOJIOgHOHHCJI0r0 6po1HeHHH BnepBble ycTa-
HOBHJI flacTep. 3TOT MHHp06 BIIOCJIeACTBHH IIOJIygHJI xa3BaHHe
Streptococcus lactis. HOMHMO 3TOPO BHga, HMeeTCH png gpyrHX
MHxpo6oB, cuoCo6HbIX c6parHHBaTb caxapa 11 BMI3bIBaTb MOJIOgHO-
HHCJIOC 6pomeHHe, B' gacTHOCTH Bact. acidophilum, Bact.
bulgaricum.
HepegHCJieHHbie BHAMT 6aiTepllii 0THGCHTCH x rpynne Bo36ygnTe-
JIOH THIIHgHOI'O MOJIO'HOHHcjioro 6p05xeHHH, o6pa3ylon1x 6bICTpO H B
3HagHTeJIbHbIX HOJIHgeCTBax MOJIOgHyIO HHCJIOTy 6e3 IIO6OgHbIX IIpOAyH-
TOB. 3Ta rpynna, xpoMe cHBamHBaHHH MOJIOHa, BbI3LIBaeT pHg pa3JIHg-
HbIX 6pOAHJIEHLIX HpOgeecOB, IIIHPOHO H3BOCTHbIX B HpaITHHe: HOJIy-
geHHe HHCJIoro XJIe6HOPO TeCTa, CHBaIIIHBaHITe HanyCTbl H orypIJoB,
upIroTOBJIeHYIe CLIJOB, CHJIOCOBaHHe HopMOB.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HapHPy C 3TIIM H3BOCTHbI pa3JIHiIHble BHPbI MHI{PO6OB HOTHHIILI-
HOro MOJIO'IHOICHCJI0r0 6p0)$eHHH, IIpH B03ACHCTBH11 HOTOpbIX MOJIOiI-
Han HHCJIOTa HaI{aIIJIHBaeTCH JIHiHb B He6OJIbfHX HOJIHLIeCTBaX H,
I{pOMe Toro, HoJIyLIaOTCH PRA ApyrHX HpOAyHTOB 6pox{eHHH.
B HaCTOHH[ee BpeMH IiMeeicn MHOrO IlpenapaTOB, HPHMOHHOMbIX
PJIH Hp0(JHJIaRTHKH II JICiIOHIIH }HeJ1yAotTHO-HHHIe1IHbIX 3a60JIeBaHHH
MOJIOAnHna COJILCHOXO3HHCTBOIIHbIX }HHBOTHMX, AJIH IIPHPOTOBJICHHH
HOTOPbIX HCHOJIb3yIOTCH 6aHTCpil THIIHTIHOro MOJIOTIHOKHCJIOro 6po-
H{eHHH - aHTaroHHCTLi rHHJIOCTHbIX MHHp060B; H 3THM npenapaTaM
OTHOCHTCH JIaHT06aI~14JIJIHH, agugoIIHJIIIH, ai ii o HJIbHan 6yrnboHHan
HyJlbTypa (ABU).
B pon eHHe HJIeTLIaTHH. B HPIIpOAO CyWCCTByIOT
6oJIb1I11e 3anacbi yriiepoAa B BHAe HJIeTiiaTHH paCTOHHI3, npii paciuenaie-
HHH HOTOpOH (HOCJie rH6eJIH pacTeHH13) ocBo6onJ aeTCH yrJlepo . HJICT-
LIaTHa paces eHJIHeTCH pa3JIIIgHbIMH 6al{TepnnM11, OTHpbITbIMH B. JI. OMe-
JIHHCHHM. H3BeCTHbi, HanphMep, McTaHOBoe 6pon lime, Hpi HOTO-
POM B pe3yJIbTaTe pa3JIOH{eHH2 I{JIeTgaTI{H o6pa3yI0TCH McTaH H
yrJIeHHCJIOTa, H BOAOpOAHOe 6pWReHHe C o6pa3oBaHHeM BoPopoPa
H yrJIeinCJIOTbi. 3TiI ABa BHAa 6po1HeHHH oeyWeCTBJ HIOTCH pa3JIHLI-
HbIMH rpynnaMH MHHpo6oB.
Bpo neHHe iuuieTLIaTKH, CoCTaBJIHIOII[elI 3HaLIHTCJIbIIyio tlacTm Tau
Ha3bIBaeMbIX rpy6bIX HOpMOB, HrpaeT Cepbe3HyI0 pOJIb B HHweBapeHHH
TpaBOHAHbIX, paiAHOH HOTOpbIX B 6OJIbfOH Mepe COCTOHT 113 CeHa H
COJIOMbI. BaI#Tepnn, pa3JIaran HJIOTLIaTHy B HHII CBapHTeJIbHOM TpaHTO
5I{Ba'IHbIX (HpynHbiH poraTbIH CI{OT), COAOHCTByIOT JIytIHIeMy yCBoenHIo
BTIIX HOpMOBbIX BeileCTB. BG36yAHTeJiH 6poncennn HJIeTLIaTHH HCnoJib-
3yIOTC31, HpoMe TOPO, B TOKCTHJIbHOH npOMbIIIIJICHHOCTH HpH 06pa6oTHe
JIbHa, a Tani ne B 6HOJIOrwiecHOii OLIHCTHe HetIHCTOT. Bpon eHHe I{JIeT-
LIaTI{H B 110t1BO COAeHCTByeT o6pa3OBaHHIO nepemnon (ryMyCa), B npo-
MbIHIJICHHOCTH H HOMY npH6eraioT AJIH HOJIyLIeHnn HenOTOpbIX XIIMH-
LIOCKHX npOAyl{TOB. BMOCTe C TOM 6aHTepim 6pO?I{eHHH HJIeT'IaTI{H
MOryT HahiOCHTb BpeP, HOPTH ApeBe6HHy, 6yMary H Apyrne BOIIJeCTBa,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IMeIOIInHe n c$oeM cocTaBe HJIeTtiaTHy, a rpH6 Stachybotrys alternans
CBOHMH TOHCHHaMH, BbIAeJIfIIOII(HMHCH HpH napa3HTHpoBaHHIi 3TOFO
rpH6a Ha COJIOMe, BbI3bIBaeT y jiomaAeH THxcenoe 3a6oJleBaHne -
cTaxH6oTpnoTOxcHHO3.
PaaJIONteHHe ICHpOB n.pOHCXOAHT McHee HHTeHCHBHO, 4eM pacHIell-
JIeHHe 6eJIHOB H yrJIeBOJ[OB. 3TO HOJjTBep9I{AaeTCR o6Hapy?HeHIIeM CHOH-
JIeHHi3 mHpa B HMaX C yxce CFHHBHIIIMII TpynaMH HiHBOTHbIX.
B pa3pyHIeHHH HrnpOB yiIaCTByIOT pa3JIwIHble 6aHTepHH H IIJIeCHe-
Bble rpl6bl. IIpouecc pa3Jlo2EeHHFI H{HpOB 3aHJIIO'IaeTCFI B HX pacnage
Ha rJIHI;epHH H pa3JIHLIHble HHCJIOThI. HpOAyHTbI pacnaga nOA Bo3AeH-
CTBHeM MHHpo60B npeTepnesaloT AaJlbneuIHIIe npespau[e1IHa.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Piaaa VII
PACHPOCTPAHEHHE MHHPOBOB B HPHPORE
Mrn po(PJIopa HO'IBbl. HonBa HpOJ(CTaBJIAeT co6oi3 cJloambiii HOM-
nJIeKC opraHHneCHHX H MHHepaJlbIlbIx COCAIIHeHnII, B03HIlEIIIIIX Ha
HoBepxHOCTH 3CMHOII KOpbI B p03yJIbTaTe C n311HO-XIIMHgIeCHHX H He
MCHee Ba7KHbIx 6nojiorlinecnHx npOqeCCOB.
HOUBa ilpe3BbILIaI3Ho 6oraTa pa3JI14LIHbIMII BHAaM1 MIIIipoopraHII3-
MOB, OCy1I eCTBJIAIOHUnX HpeBpaH~eHHC BeIBecTB B npup0AC. B BCn
BCTpeualoTCn 6anTep1114, Ap0i ?Kn, IIJlecean, aHTIIHOMnIACTbI H Apyriie
(JiOpMbI. HOtIBCHHbIl3 peHCIIM - BJia)KHOCTb II KaIIHJIJInpB0CTb, TCMIIC-
paTypa, peaugun epeAbi, McTeopoJrorngecnlle II KJIrrMaTHgeCKIIe ycJlo-
BHH - BJIHHCT iia COCTaB MHKpo4mopN H cc BbISICIIBaeMOCTb. OTMC-
LIeHO, HanpHMep. 'ITO MaKCnMyM MHKpo60B IIaXOAIITCn B nO'IBe B TeIIJIOe
BPCMH toga. HOaHgCcTBO MHKpo6oB, HaceJIiIIOMIIX HoiIBy IIa pa3Hbix
cc ray61maX, Heo liHanOBO: B 3eMJIe, B3HTOn C IIOBCpXHOCTH 110JIB,
6bIJIO yCTaHoBJieno 2 564 800 KoJlomifi; Ha rJiy6nnie 2 M (rr iira) -
23 100; Ha rJry6HHe 3,5 M (rpaBHb) 7170; Ha rJ1y6HHe 4,5 M (ne-
coi) - 1500; Ha rny6HHe 6 M - 0. HOtIBCIHIble MHKpo6hl He TOJIEKO
ynaCTByloT B (JopMnpoBaHHII notIBbI, HO HrpaioT H CyMCCTBeIIHyIO pOJIb
13 IIOBbJmeHnII cc ypoHianIIOCTII.
AJI}I 3I1113001OJIOI'OB it MlHpo6noaoroB IIMeeT 60JIbIJO0 HpaKTn-
necnoe 3HaIIeIIHe 3aceneHIIe HO'IBI,I naTOrCIIHbIMH MIIKpOOpraH143MaMIr.
HOCJIeAHHe n0IIaAa10T B II09By C BblgeneHHIIMn HCHBOTHbIX It HX Tpy-
naMH, OAHaEo Ha BbI}ISHBaeMOCTb IIX OKaabIBaIOT BJIIIIIHHC HaJlnnne
BJlarn, OpraHnnIeCKIIX BCII[CCTB, MHoroiIHCJIeIIHon canpo nTHOn MnK-
pO(J)JlOpbi, C HOTOpOI naTOrdnHbIM MlKpO6aM BeCbMa TPy9110 KOHKy-
pnpoBaTb, peani wi epeAbl, aapar ini. ToJIbnO Cnopoo6pa3yronne
MlKpo6bI B COCTOHHIIII B TeneHne AJIIITeJIbHOrO BpCMeHII IIpOTIIBOCTOHTb
BPCAHbIM nOnBeHnbIM B03AeiGTBHHM, H0CII0p0Bble }KC (OpMbI 60JIbmeII
uaeTbIO IIOrH6aIOT. 113 IIaTOrelHbIX allaapo60B uaCTbIMi 06HTaTeJIHMH
IIOiIBbI (no AaHHbIM 6awTeploJIOroB, HCCJICAOBaBInHX 06pa3I[bI IIOLIBLI
Ha pa3HbIX yuaCTKax (f pOHTa BO BPCMF BOHHbI 1914-1918 rr.)
HBJIHIOTcn: B. perfringens (B 100% necaegoBalHH), B. sporogenes
(80%), B. oedematiens (45-64%), B. tetani (27%), Vibrion sep-
tique (8%), B. botulinus (6%), B. bistolyticus (2%). OAHaHo HaH-
60JIee Ba?KHMM FIBJIBCTCHH HaJImIne CIi6Hpen3BeHH0ro MIiHpo6a, Cn0-
co6Horo COXpaHHTbCn B IIogBe g0CffTIIJI0THFIMII if npu 6JIaronPHIITHbIX
yCJIOBIIHX pa3MHo5KaTmcFI B ne11, BCJICACTBHe Hero C03AaIOTCH CTaIjHo-
HapHble OTiarn Bb13bIBaeMon TIM 60JIC3Hii.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
143 HOCIIOpOB1IX (JIOpM B nOLIBe MOryT HaXOA13TbCH BO36yUHTeJ111
Ty6epl{yJle3a, po1KH cBnueu, Herpo6aIu1JIJIe3a, napaTH(a H HeHOTOpbMO
Apyrre. FIX coxpaH}1 MOCTb npH 3TOM HeO IIHarOBa, HO He HpeBbIIIlaeT
AJIH Ha116OJiee yCTOW1IHBbIX BHAOB HeCHOJIbHHX Mecnr eB.
B OTAeJIbHbIX CJIyTiaaX BeTepHHapHbIM CneI ItaJIHCTaM npHXOAHTCH
IICCJIOAOBaTb IIOLIBY Ha HaJi1YHO B Heft IIaTOreHHbIX MHHpO6OB (Bo36y-
AHTOJIOIi c16upcHoH H3Bb1 H AP.). ,I1,JIH 3TOPO 1IOJIb3y1OTCFi duel[HaJIb-
I1bIM 6ypaBoM c MexaHHLIeCHH 3arpblBalowencr H OTHpbIBafO Hello
IIOJIOCTbIO, HOTOpbIM B pa3HbIX piacTHax H3BJIOHaIOT HeCKOJIbHO upo6
IIOtIBbI; CpeAHHFI Bec IIpo6bi 0,5 Hr, a Bcero Ha6HpalOT Ao 5-10 Hr.
IIp06bl 3eMJIH IIOMOWaIOT B CTeJJIHHHble 6aHHn 11 OTIIpaBJIHIOT B JIa6o-
paTOpHlo.
MuKpo4IJIopa BOJ bl. HO caoeMy npOHCX09KAeHHI0 npHpOAHble BOAbI
AOJIFIT Ha aTMOC())epHble, HJI11 McTeOpHbie (AoxcAb, CHer, HHe1, poca),
IIOA3eMHb1O (rpyHTOBble, apTe3HaHCKHe), IIOBepXHOCTHhIe (perH, o3epa,
IIpyAbl, 60JIOTa) H Mopclre. ATMoc(epuble ocaAHH, BbInaAan Ha 3eMJ1lo,
CJiyHCaT HCTOLIHIIKOM o6pa3OBaHHFI Ha3eMHbIX BOAOeMOB, rpyHTOBhIX
H apTe3Hanclcnx BOA.
B aTMOCf epHMX BOAax O51,P1HO co epxcaTCH B paCTBOpeHHOM
COCTOHHHH B03AyX, a30THaa u a30TIICTafi KIICJIOTLI, aMMHaic, opraHIl-
iieCKHe cOeAHHeHHH, COJiH HaTpHFI, HaahgaH, MarHHIi, IT, KpoMe Toro,
BO B3BCHICHHOM COCTOITHHH MME. H 6aHTepHH. CTeneHb 3arpH3Heu-
HOCTH aTMOC())epHhIX BOA 3aBHCHT OT COCTaBa IIOLIBbI H McCTHbIX CaHH-
TapHbIX yCJIOBIiT. B H OMbI11 JIeHHLIX panOHax, rAe B B03AYXC HOCHTCII
MHOrO nbIJIH, camH H IIMeIOTCH pa3Hble CCpHHCTble COCAHHeHHH, BOALI
MOryT co epacaTb HX B 60JIbIIIOM HOJIwIeCTBe.
FpyHTOBhIe BOAhI o6pa3yIOTCH B pe3yJlbTaTe IIOrJIOweHHn nOiIBOH
ocaATOB; oHH CHaIIJIHBaIOTCH Ha IIepBOM OT 1OBepXHOCTH 1IOiIBb1
BOAOHenpOHHI;aeMOM cJIOe. rpyHTOBble BOAbI MoryT 3arprI3HFiTbCn,
ICorAa 3arpr3HHeTCH BepXHHH IIpOHimaeMbIn IIJI3CT IIOLIBbI B MOCTe
HalOIIJleHIin rpyHTOBbIX BOA. ApTe3HaHCHHe BOAbI, 3aJleraIou rte
rny6ouo MOHCAy BOAOHOIIpoHHB;aeMbIMH nJIacTaMH, 06h1iIH0 He 3arpH3-
IHnOTCII.
3arpn3HeH11e IIOBOpXHOCTHbIX BOAOCMOB (peH, 03ep, IIpyAOB),
a BMOCTO C TOM 3apaaiceHHe HX naTOPCHHbIMH MHHpo6aMH lPOHCXOAHT
pa3JIHMHbIMJI cuoco6aMH; OHO B03MOHMHO IIpH He1OCpOACTBeHHOM
CnyCice CTOLIHbIX BOA B BOAOeMbI, BCJIOACTBHe npoCat1BaHHH B KOJIOAIXhI
COAOpHHHMOFO BbIrpe6HbIX HM HJIH CTO'IHbIX BOA, oCO6CHHO HorAa
noc ieAHHe 6JI113HO paeno io iceHbI H HCTOLIHHHy IIHTbOBbIX BOA. CHJIbHMIe
JIHBHH, CMLIBaIOHWHe rPFl3b H HaB03 C 1IOBepXHOCTH HOLIBhI H HecywHe
HX B OTICpbITble BOAOeMhi, TaHxce CH0006cTByIOT 3apaxcenHlo nx naTO-
FeHHhIMH MIHcpo6aMH. BOJIbIIIyIO pOJIb B HpeAOXpaHeHHH OT 3apamceHHH
BOAOOMOB HrpaIOT IcyJlhTypHbIC HaBbIHH HaceaeHHH, 9IiHBYIIWOrO Ha
6epery BoAoeMa HJ1H B ero olcpeCTHOCTHx.
B IIpilpo e Ha6J1IOiJaeTCH (JeHOMOH caM00iIHWeHHII BOAOeMOB
B pe3yJlbTaTe B03Ae13CTBHFI IIa HHX pnAa (H3HileCHJIX, 6HOJIOrHLIecHHx
H XHMIILIecICHX (J)a1cTOpOB, H HOTOpEIM OTHOCIITCH: 1) COJIHetHbIII CBOT,
2) MCXaHHuCCKOC AOHCTBHC ABHHCCHHH BOAbI, 3) Ho,7IIJ ICCTBOHHO0
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
coOTHOHI0IIHO co ep?Hau{nxcfi B. Bone naTOFOHIILIx MHHpo6OB H can-
poc HTOB, 4) c arol(HTO3, 5) 6aHTepHoc arm, 6) HOHOTOpbJe XHMH-
nOCHHe Beu{0CTBa, HaXOAHUineCH B BOAe.
143 IIaTOreHHbIX MHHp06oB, HMOIOWHX 3HageHHe B naTOJIOrHH geJIO-
BOI{a, B BOAe HaXOAHT BO36yAHTeJIOU 6pIOIIIHOPO TJi )a, xOJIepbI, AH30H-
TepHH H Ap.
B BOAC MOI'yT 06HapymiiBaTbCH: 13036yA11TeJIb C146HpCHOH H3BM,
3M(113eMaT03HOro Hap6yHHyJIa, HH(e1B;HOHHOH aHCMHH JIOUIaneH,6py-
IieJIJIe3a, Cana u pHAa Apyrnx 6oJIe3HeI3, BO36yAHTeJIH HOTOpMIX CHO-
C06HN 6OJIee HJIH Mexee npoAOJIMIlTO ThHOe BpeMH HaXO HTbCU B BHpy-
JIeHTHOM COCTOBHHH B BOAe.
Oco6ylo poJIb HrpaIOT 3apaMeHHble BOnOeMbI B paCIIpOCTpaHOHHH
JIeHTOClhIpO3a ?HHBOTHMIX. JIeHTOCHHpb!, BbIAeJIHfICb 143 OpraHH3Ma
XO3HHHa H IionaAaH B BOAOHCTOgHHHH, MOFYT COXpaHHTbCJI B HHX
B TeMIOHH0 AJIHTeJIbHOPO cpo a H npH 6JIarOnpHHTHhIX YCJIOBHHX
pa3MHOH{aTbCH B HOH; 6yAytH yCTOII?IHBbIMH H H113HHM TeMnepaTypaM,
OHH He TOpIIIOT ?HII3HeduocO6HOCT14 3HMOH B He3aMep33IO1IIel rJIy6HHe
BOAOeMOB 11 B HX JICAFIHOM HOHpOBe.
BBHAy TOrO iITO Boa MO?HeT 3arpH3HHTbCH (eHaJIbHbIMH MaccaMH,
60raTLIMH HHIneLIHOH MIIHp0 )JIOpOH H B TOM LIHCJIC B. colt, onpeAeJle-
HHC HOJIHTHTpa BOAbI (T. C. HaHMCIIbHIerO IIOJIHLICCTBa ee, B HOTOpOM
HaXOAHTC}I HHHIeLIHaFI uaJIotIHa) CJIY?HHT ICOCBOHHbIM 1OHa3aTCJIeM
3arpf3HCHHH BOALI HHHICLIHbIMH MHHpo6aMH, B LIHCJIO HOTOPMIX MOFYT
6bITb naTOreHHble . BHAbI. 1TO6bI u0Ha3aHHFI HOJIHTHTpa 6birnH upa-
BHJIbHbI, BOAY Ha6HpaIOT OCO6MM npII6opoM, CTapalcb upeJyupeIHTb
Ce B03MO5HHOe 3arpfl3aeHHe. Bona C'IHTaCTCII HenpHrOAHOH AJIH IIHTbH
HpH HOJIHTHTpe 5 H MeubTIIe; 3T0 03HwIaeT, 1ITO B 5 MJI HCHbITyeMOH
BOAbM 6blJia HaI3AeHa HHHICLIHaH naJIoglla.
MIIHpoc Jlopa B03Ayxa. B03AyX 3arpfl3HfI0TCH MHHpO6aMH rJIaB-
11MM o6pa30M 143 HbIJIH, 1OAHHTOH C 3eMJIH, C HOJIOB CHOTHbIX ABOPOB
upH HX HOAMCTaHHH, 0006eHHO CYXHMH McTJIaMH, C HaneJIbRaMH BOAbI;
nouaAaHHo MHHpo60B B B039YX B03MO?HHO HpH HaIIIJIe ?IdHBOTHLIX
11 LICJIOBCHa BMCCTO C HaueJIbHaMH CJIH311, B HOTOpLIX MHHpo6bl MoryT
AOBOJIbHO AOJII'O CyII eCTBOBaTb. OAHaHO B03AYX He upCACTaBJIHOT
co6OI3 6JlaronpnFITHOI3 CpeAbl AJIH H 113HCACFITeJIbHOCTH MHHpo60B,
Tax HaH oHH rII6HyT B HeM OT AeHCTBHH HpIIMOrO COJIHeLIHOrO CBeTa,
BbICynIHBaHHfl, OTCYTCTBHH HHTaTCJIbHLIX BeweCTB. ,,JIHTeJlbHoe BpeMH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B ropogcxoM lTapxe - 200, Hag MopeM - 1-2, B ApRTHKe - 0-1.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Hble MIn po(b1. Ha CJI113HCTOI1 o6oJIO4ICe pOTOBOI IIOJIOCTII HaxogiuIII
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
13HOCHT16 13 CHJIOCHyTO Macey HyJIbTypbl MOJIOtIHOHHCJIbIX MHHp060B
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
0603BPOMHBaHIIO HaB03a OT HaTOreHHLIX MHHpoopraHH3MOB AocTH-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
6pyAeJIJT (oco6eHHO onacno Aim *ieJTOBexa MOJIOHO oaeri H I4o3), 60JIb-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
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69
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BaTb HaH MeponpHFITne, rapanTHpyIOmee BO BCeX 6e3 HCHinowHHn
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
6oJIe3H}IM BCero opraHH3Ma. Tall, "PH cH611peROIi FIaBe, no MxeHHIo
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
AHTHTe7Ia. AHTIITeJIO - BeII;eCTBO, HaxoAHIImeecH B HMMyHHOI3 CbI-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
j[eJ1OHHOe pa3B0geHHO CbIBOpOTKH KpOBH HCIIbITyOMOFO HUIBOTHOrO.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIOJIOHfaTeJlbHylo peaRullo, IIpH ROTOpOI3 6OJIbIHIIHCTBO HPaCHbIX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
O II C 0 H H H bI - allTHTeJla, HaJIHzIHe HOTOphIX MOHCHO yCTa-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
P 0 JI b B H T a M H H 0 B B yCTOU IIBOCTH OpraHH3Ma MHBOTHbIX
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
06oJI0tIHII - 3nHTeJIHfI, a 8 HeHOTOpbIX cJiyuafix H AOfTOJILHOCTb
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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cTOJI6HHKa); 5) THaxeBble BaKI(HHhI (IIpl 3a6oJIeBaHIIFIx, BhI3BIBaeMMx
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LIyMbI HpyHHOrO poraTOro CH0Ta). THaaeshe BaHI1IIHBI, nOCROJIbHy
B MaTepHaiie, 113 KOTOporO OHH FOTOBHTC$I, IIMeeTCFI }H11BOi3 BHpyc,
o6LrgHo o6e3Bpe?KHBalOTCH ()opMaJI11HOM; 6) AeIIOH11pOBaHHbie BaKIjH-
HbI, K KOTOpLIM Ao6aBJIHeTCH HaHoe-uH6o BeluecTBO, 6oJlbl11epi gaCTbIo
rHApooHHcb auIIOMHHIIFI, BhI3hIBaIOIIIee BOCIIaJIeHHe B McCTe HH'beHI;II11
BaHgHHbI C ) eMapHaI;11oHHbIM BaJIOM; TaHHM o6pa30M, opraHH3yeTCH
BaHII110HHOe Aeuo, OTHyAa HocTeneHHO paccacbluaeTCH aHTIIreH.
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Jla6opaTOpxblx MHBOTHhIx), CTepHJIbHOCTb (noceBOM Ha HHTaTeJlbable
cpeAbi) H aKTHBHOCTb (Ha Jla6opaTOpxmIx ?KHBOTHmIX).
BaHIIHHaI;IIH C03AaeT Y Hf11BOTHbIX aHTIIBHbIFI 11MMyH11TeT pa3JIIIiI-
HOII AJI11TeJIbHOCTH H HaIIpH?KeHHOCTH, HOTOpble 3aB11CFIT OT CBOHCTB
IIH(eHTIIIOHHoro areHTa, xapalTepa IIH(eHI;IIII 11 yCJIOBHiI, B HOTOphIX
HaXOAIITCH BaHIIHHHpyeMoe HoroJIOBbe M]aBOTHMX. IIpH IIJIOXOM
COAepmaH11H 11 KopMJIeHHH aHTIIBHbIII HMMyHHTeT Mo?KeT OKa3aTbCH
BeCbMa HeAOCTaTOgHMM H HpaTHOBpeMeHHNIM, a B oTAeJIbHhIX CuyKaHx
COBCeM OTCyTCTBOBaTb.
rHIf epHMMyHHble ChIBOp OTKId uoJIyLIaIOTCn B pe-
3yJIbTaTe BBeAeHIIH B HapaCTaiOH;Hx A03ax HC11BOTHbIM-HpOAWI[eHTaM
CHanajia BaKILHHHMIX, a 3aTeM HeoCua6JIeHHhIX IIITaMMOB B036yA11TeJIH
WI eHI;11II, IIPOTHI3 fCOTOpOI3 IIOJIynaIoT 3TOT upenapaT,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
FHHepHMMy1H3agITfI - IipOIIecc 06bhIII0 AOBOJTLHO AJIPITCJIbHbIH.
nO OHOHgaHIIH IIepBOrO I[IIHJIa rIHepHMMyHH3aIr13H IIPOBOjjFIT IIepBoo
ISpOBOHyclaHHe 11 113 RPOBII IIOJIy'IaIOT CbIBOpOTHy. Hocile 3TOr0
tlepe3 OHpOAeJIeHHbII3 HHTO BaJI cJlegyeT HOBbIH I[HHJI rIIIIepIIMMyHII-
3aIAHII C HOCJIeAyIOMIIM Hpo13OB39TIfeM. Maw BCOFO gJIH rHHepHM-
MyHH3ar irn HCIIOJIb3yIOTCH JIOHIaRH; HpOJJyUUeHTaMH MOryT 6LITb Tan1ne
HpylHbIIi poraTbIH CHOT II CBHHbH. FluIIepHMMyHHyIO CbIBOPOTHy Hp0-
THB TIyMbI HPyHHOFO poraTOrO CHOTa noiIyialOT OT 3TOFO BIIga 1ICHBOT-
HbIX, IIPOTHB tiyMM CBHHCH - OT CBHHCH.
JIB rnhepHMMyHH3aIjuu IICIIOJIb3yiOTCH TOJIbHO 3AOPOBble ?HHBOT-
Hble H3 6JIaronoJIytIHbIX II0 3apa3IIbIM 60JIe3HHM X03fIHCTB. EcJIII
rH1iepnAIMyHH3aIJnH HpO113BOAIITCH OjJHHM BHjAOM IIaTOreHHOI'O MHKpO-
6a, noJlytiaeMyio CbIBOPOTHy Ha3bIBaIOT MOHOBaJICHTHOH (HanpiMep,
IIpOTlBOCH6HpehI3BeHHaH CbIBOpOTna); HPH IIMMyHII3aIUIIH AByMH pa3-
HbIMH BHJ{aMH B036yA11TeJIeII CbIBOpOTna Ha3bIBaeTCFi 6HBaJIeHTHOH; HO-
JIHBaJIOHTHaH CbIBOpOTHa HOJIyMaeTCH IIpII rIIHeprIMMyHH3agnH MHOFHMH
BHAaMH MHnpo60B (IlaripHMep, cbIBOpOTHa HPOTHB ra3oBbix OTCHOB).
HepeA BbIHyCHOM CbIBOpOTOI g an npaHTIItIeCHOro IIpIIMeHeHIIH
HX, TaH Hie HaH BaHUHHbI, HpOBephIOT Ha CTepIIJIbHOCTb, 6e3Bpej[-
HOCTb H aHTIIBHOCTb. BbIHyeHaeMbIo rn1eplMMyHHble CbIBOPOTHII
HOHCepBHPyIOTCH 0,55-11pOIZeHTIIbIM paCTBOPOM (1)CHOJIa;
Hpu He1OTOPbIX 3a60JIeBaHHFIX, rJIaBHbIM o6pa3OM MOJIOj[HiHia
COJIbCHOXO3fIHCTBeHIIbIX limBOTHbIX, B HatIeCTBc IIp0(HJIaHTHtleCnOrO
ii Jlet3e6Horo CpeAcTBa HPHMOHHIOT CIICUH0tiecHHI3 6aHTepno(ar (Ha-
HpHMep, HpH IIapaTIIC O II HoJIH6ai[HJIJIe3e). B Jletle6Hblx Iuenux HpH
OTJ1;eJIbHhIx HII(eHgIIHX (HanpHMep, HPH MbITe) 14cIOJIb3yIOT aHTHBH-
pyc. AHTHBIIpyC IIpeAcTaBJIHeT C06oH (HJIbTpaT 2-3-HeAeJibHOIi
6yJIbOHHOH HyJIbTyPbI HaTOreHHOPO MHHpo6a (HaIIplMep, MEITHOPo
CTpeHTOHOHHa). B (IIIJIbTPaT IIOpeXOJ[HT IIPOAyHTbI Hin3Hej;eHTeJib-
H09I'Jg HPII{po6a, H HOBble HOCOBbT aTOro MHHpo6a B (JHJIETpaT ynie
IIe AauOT pocTa. BHepBble gJIFu Jletie6Hblx a eJICI3 aHTHBHpyc 6bIJi Hpej--
JIOIHOH Be3pejHa, B BeTepunapiylo HpawTHHy B CCCP ero BBOJI
14. H. CaAOBCHIIFI.
HBJIeHHH HMMyHHTeTa IIIIIpOHO IICHOJIb3yIOTCH B J[HarHOCTHHe
MHOrnX HH(J)e1I[HOHHbIX 60JIe3HOR }nHBOTIIbIX. ,JI}I THarHOCTHnII
6pyueJIJIe3a, HyJIJIOpo3a, JIeIITOCHHp03a it Apyrnx IIpii6eraloT H
pean1IIH arrJHOTIIBaquit (PA); gm gIIarHOCTHnn caria, 6pyI CJIJle3a,
rleplIHHeBMoHHH npynHoro poraTOrO CHOTa, cJIytIIIOII 60JIC3HH JIO-
maj;enI ii gpyrHX - H peangini C]3H3buBa}IHf3 HOMHJIeMeH'ra (PCH),
AJIH AlIarHOCTHHH c116IIpcHof f33BMI-n peauniIII HpeB;HHHTaAIir 11 T. A.
RBJICHHH HMMyHHTCTa HpnMeHHMbI H AJIH TepanHII }HHBOTHbIX,
60JILHbIX HII(enijuouIIbIMH 60JIe3HfIMII. B Jletle6HbIX IUCJIHX, Han
yna3blBaJIOCb BbIHIO, ylOTpe6JIHIOT rnnepIIMMyHHble CbIBOpOTHII, 6aIi-
TepnocJ ar, aHTHBHpyc.
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ChIBOpOTlJi H Ilp., a Tan}He aJiileprlltlecnlle H Cep0JiorRucei IIe McTOAbI
j[HarHOCTHHII iiOJIytiIIJIH HcJJI[ogHTeJIbHO IHIIpOHOe pacrpoCTpauIeHHe
B HpaRTHHe IIpOTIIBOBIIH300TIMOGRIIX MeponpIIHTHII,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
1'.4aaa XI
OCHOBHbIE METOAbI H TEXHFIKA MHKPOSHOJIOrHgECIfHX
HCCJIEAOBAHHfl
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gHaJIbxbII3 OuTHtIecHHII HpI36op - M H H p o C H o n. HpH ero HoMOII;H
j[ocTHraeTCH yBeJIHt1eHHe pacemaTpHBaeMoro HpeAMeTa OT HeCHOJIb-
HHX COT AO 2000 pa3. MHHpoeHOHbI 6bIBaIOT HpocTmIe 11 CJIOHCHble.
HpocTble MHHpOCHOnbl, CocTORMIle 113 OAHOPO HJIH HeCHOJIbHHX
yBeJIHLIHTeJIbHLIX cTeHOJI, AaIOT He6oJIbIIIOe yBeawieHHe. AJIH
H3yneHun MHHp06HbIX HJIeTOH H006XOA14MLI CJIOH{Hble MHHpOCHOHbI,
COCTOHH;HC H3 gByX LIaCTeA: McXaHH'IeCHOH H OHTHLIeCHOH.
MexaHHtIecHaH qaCTb MHHpOCHOIla COCTOIIT H3 uITaTIIBa; B HO-
cJIegHCM pa3JIHLIaIOT HHHCHIOIO tIaCTb, HJIH Ho}HHy MHHpocHoIla, n
BepXHIOIO tlaCTb, HJIH HOJIOHHy, COCqHHeHHyIO C HH1HHeH tIaCTbIO
IuapHHpoM. H BepXHeII taCTH HOJIOHHH HPHHPOIIJICII Ty6yc (Tpy6a)
MHHpocHona, H ee HH?HHCH tIaCTH - HPCAMCTHbIH CTOJIHH.
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HOH 4)OpMhI, HMeeT OTBCPCTHO J[JIH upOXOMACHHH CBCTOBbIX JIytleH.
HOCpeACTBOM BHHTOB ero Mo1HHO HCPeABHraTb B J(ByX B3a1MHO Hep-
HeHJpHHyJIHpxbIx HalpaBJIeHHHx. Ha CTOJIHH HoMeuuaeTCrl o6'beHT
HCCJIegOBaHHH - HpeIIapaT, HpHHpeIIJIeHHbII3 AByMH 3aHSHMaMH -
HJIeMMaMH.
B BCPXHIOIO qaCTb Tpy6bl BCTaBJIHeTCH OHyJIHp, B HHSHHeJ3 ee
tlaCTH HaxOAHTCH Bpaujalo WHIICH J[HCH c OTBCPCTHHMH - peBOJlbBep.
B 0TBCPCTHH PCBOJIbBepa BBHHtIHBaIOTCH o6'beHTHBN. Tpy6a MHHpo-
CHOHa HepeABHraeTCH BBCPX H BH113. BOabuloI3 (MaHpoMeTpHtlecHHI3)
BHHT CJIyHfHT J[JIH IIOAHHTHH H onycHaHHH Ty6yca Ao HpenapaTa Ha
HPOAMOTHOM CTOJIHHe HOA HOHTpoJIeM rjia3a (cMOTpeTb c6oHy). Ma-
JIbIH (MHHpOMCTpH'IeCHHH) BHHT IIOJIHbIM HOBOPOTOM HepeABHraeT
Ty6yc MHHpOCHOUa Ha 0,1 MM; HM IIOJIb3yIOTCH HPH HeuOCpeACTBeHHOM
paCCMOTpeHHH rlpenapaTa.
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Horo aHHapaTa, o6'bewTHBa H OHyJIHpa.
OCBeTHTeJIbHbIII aHHapaT paCHOJIO}HCH HoA Hpej[MeTHbIM CTOJII4HOM
H COCTOHT H3 3epHaJIa H HOHAeHCOpa c J.{Ha(parMoH. 3epHarto CJIyn 1IT
JAJIH HanpaBJICHI1H CBeTOBbIX Jlytlell H HCCJIeJZyeMOMy HpelIapaTy.
OgHa CTOPOHa aepHaJIa uJIocHaI, Rpyra5 - BoruyTaa. Hpn J];HeBHOM
1 Hanucaua Ha1AxJ;aTOM BeTepxuapHbIx uayx C. C. I'xTeabCOH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CBCTO IIOJIb3yIOTCFI HJIOCICFIM 3CpHBJIOM, npii HCHyCCTBCIJIIOM OCIle-
II(OIIHH - BOFIIyTb1M.
H 0 H A C H C O P (GryCTIITCJIb) HpH IIOMOWU CBOHX j[ByX JIHH3
co6HpaeT CBOTOBJIO JIyMH B I OHyCe, I{OTOpbIII J 0ME0H HaXOAIITbCFI
B HJIOCI{OCTH pacemaTpIlBaeMoro IIpenapaTa. CJICBa OT HOHACHCOpa
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CBeTe H0II eHCOp IIOj;HIIMaIOT (AO ypOBHF4 npeAMOTHOPO OTOJIHHa);
Piic. 15. CoEpeMennblii 6noJlorn=IecrHfi MHHpocnon:
S - HOJIOHIc2; 2 - Homtia; 3 - mapHHp; 4 - npe;MeTHbOl CTOJIIIH; 5 - TyOyc; 6 - Maxpo-
McTpI19eCHHf3 BHHT; 7 - MIIHpOMeTpugecHIIa BHHT; 8 - peBO.nbBep; 9 - aepla.uo; 10 - HoH-
Aellcop; 11 - o6ieHTHB; 12 - oxynnp.
npn ITCHYCCTBCHHOM ocBelfCHHH ero OnycHalOT AO Tex nop, no a
H3o6pa5KeHne HCTOiIHn1{a CBeTa (HacTOJIbHOI3 JlaMnbl) He lOHBIITCH B
IIJIOCHOCTH npenapaTa (npn MaJIOM yBCJIIl=IOHHH o6'beHTHBa). CTenenb
IlpoxoHlf OHHH JIYMOI3 B MHHpOCHOI, OTpa7HCHHblx 3epxaJIOM, peryJlH-
pyeTCFI npnc-Iu1a(parMoll. OHa HaxOZ(HTC5I B HHSKHOl3 gaCTH HoHAeH-
copa. Hpn HoMO1uH pbiuara MO?HHO yBCJ1IYllBaTb IIJI14 yMCHbIIIaTb
OTBOpCTHe ) Ha()parMbI.
O 6'b C H T 11 B BBIHHilIIBaCTCFI B OTBepCTnC pCBOJlbBepa (B HHHfHen
iIaCTn Tpy6bi MIlnpocnona, IlanpaBJlennol3 K o6'beHTy IICCJIeAOBaHHfi).
HecHOJIbHO JIHH3 ero, 3aI{JIEO9eHHhIX B McTaJIJIHLIecHylo onpaBy,
HMCIOT I};HJIHHApnllecKylo 4)opMy. Ha o6'bel{TliBax c0BpeMeHHblx
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MHHpOCKOnOB I[H()pOBITe 06031meHHn (8, 10, 20, 40, 60, 120) ysa-
3bIBaIOT CTeneHb yBeJIHReHHA. O6'beKTHBBI MHHPOCKOIIOB CTapbIX
CHGTCM cna6HCeHw o603Hag0HIIfIMH 1, 2, 3 H T. A. HJIII 6yHBaMII -
A, B, C, D H DD.
06'IOKTIIBM 6IIBaIOT cyxHe H norpyxcnble (NMMCpCIIOHHMe).
B MHTpo6HOJIorlUecHou IIpaRTHKe IIOJIb3yIOTCFI rJIaBHbHM o6pa-
30M IIMMepGHOHHbIMII 06'beITIIBaMII - MaCJIIIHhIMH HJIH BOAHNMH.
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(IIJIII ero 3aMeHHTeJIH - HeApoJIn). B 3Ty Halro OCTOpO?KHO, IIOA
KOHTpOJIeM rJIa3a (CMOTpeTb c60Ky), norpyHCaIOT c pOHTaJIbHYIO JIHH3y
IIMMepCIIOHHOFO o6'beHTHBa, OCTOpOHfHO onycHan Ty6yc MHKpocxona
Bpau eHHeM 6oJIbHIOro BIIHTa npasoi3 pyxOI. 3aTeM, GMOTPFI B OKyJInp,
McAJIeHHO IIOAIIIIMaIOT 60JIbmHM BHIITOM Tpy6Ky Ao Hcnoro pa3JIH-
geHHH o6'benTa, a AJIH noJlyileHHH HoHTpaCTHoro H3o6pa}nenHII
cJlerxa IIOBOpatIHBaIOT MaJImrn BffHT (BHII3 II BBepx), He OTpMBan
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IIpeABapHTeJIbHO IIOAHIB Ty6yc 6OJIbIIIIIM BHHTOM; JIHH3y 061,eHTHBa
penoMenAyeTCH Cpa3y me IIpOTepeTb iIHCTOH CyXOH TpfIHOtKOH.
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yxyAinas KaLIecTBO o6'benTHBa, a npOTHpanne ero 60H3HHOM HJIII
HCHJIOJIOM He peHOMeHAyeTCH, TaI KaH npn 3TOM paCTBOPJIeTCSI Ha-
HaACHHH3 6aJIb3aM, CHpenJIHI0IIuHI3 JIIIH3M o61eHTHBa.
0 K Y JI fI p, BCTaBJIHeMLHI B Bepxuioto ilaCTb Ty6yca MHKpocxona,
IIMeeT ABC JIIIH3bI, CKpeuJIennble McTaJIJIHgecnou onpaBOR. BepXIInsI
JIHH3a - rJIa3Han, HII?KIIIIfI - C06IIpaTeJIbHas1. PaCCTOFIIIne McMAy
JIHH3aMH paBHO IIOJIyeyMMe IIX ()OKyCHNIX pacCTOBHIIH. IJHC pbI Ha
onpase OHyJIIIpa o6o3HaLIaIOT COOTBCTCTBYIOH[He cTenenH yBeJIH'Iennn
nao6pa neHHfI, nonyilennoro o6'beKTHBOM.
06mee yBeJIH'IeiHe MHKpocHOIIa BbILIHCJI$IOTCII IIepeMHOHCeHIIeM
LIHCeJI, yIa3MIBaIOIILIIX eTeneHb yBCJIHTIeHIIH o6'beHTHBa ICI CTeneHb
yBeJIHiTeHIIfI onyJrnpa. HanpHMep, HMMepCIIOHHhHI 06'beITHB C HO-
Ha3aTeJIeM yneaHneHHH 90, a onyJlnp - 10 x AaeT o61uee yBeJIII-
tICHIIC B 900 pa3. HMMepCHOHHHO 06,LeITHBbI C 0603HageHHeM '/,,
AaIOT yBCJIHileHHe IIPIIMepHO B 100 pa3. HpeAeJi BHAHMOCTII (Him
pa3pe1IIalowan CII0c06HOCTb) 60JIbmIHHCTBa MHKpOCKOIIOB panes
0,2 MHICpoHa. RJTH 113y'ICHHfl 06MHTOB McHbIIIHX pa3MepOB, Hepa3JIH-
LIHMMIX B 06hITIHbIX CBOTOBLIX MIInpoCHOIIax, IIOJIb3yIOTCII 3JIeKTpOH-
HbIMII MHHpoCHOIIaMII, AaIonUTMH yBeJIHtIeHIIe B 20-40 TIilCITt pa3.
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CTCHJIe pa3MepaMn 7 X 3 CM II TOJIII[HHOH 2 MM. HOBepXHOCTb CTennna
AOJI?HHa 6MTb LIHCTOII, o6e3?KHpeHHOII (IIaxecexnafl Ha Hee KaIIJIFI
MHAHOCTH JTerno pacTeICaeTCH). H0BMMe CTeHJIa npoMMBaIOT BOAOII,
3aTOM CIIHPT-3(HpOM (CMemmaHHMX B paBHbIX LIaCTFIX).
HCnoJIb3oBaHIIMIe CTeHJIa o6e3Bpe?KIIBaIOT Heo*IIIH(ennon3 cep-
ROIl KHCJIOTOI3 HJIII 5-npOI;enTHMM paCTBOPOM Kap6oJTOBOii KHCJIOTMI,
IIPOMbIBaIOT BOAOH, KIIIIJITIIT B 2-IIpOI[eHTHOM paCTBOpe COAbI H B
MbIJIbHOII BOAe. CTeIna, IIOCJIe KIIIIntenna xoponI0 IIpOMLITble BOAOH,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIOrpySHaIOT B CMCCI CII1rpT-3(f lpa AJIB o6e3BfpuBaHHH. TJIICTLIO
CTCHJIa 6opyT IIHHi OTOM.
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OpraHII3MOB ueo6XOAHMo CAOJIaTb Ma30IC, OICpaCHTb H paCCMOTpeTb
CPO IIOA MHHpOCHOHOM.
HpexCAe BCero HoA6Hpa1OT =HICTOC npeAMeTHOC CTORJIO 11 3a?Hu-
ralOT cnnpTOBRy. IIpo6npHy c 6aHTepIIaJlbnoA HyJlbrypor3 npnAep-
SICHBaIOT B IIaiCJIoInIoi HOTIOSICCHHn 60JlbHJIIM HaJIbi[CM Ha iiaAoHH
JIeBoII pyICII; npo61Cy npo6npiCH HaIIpaBJ11IIOT B CTOpOHy HJIaMerIH.
3aTeM B3HTYIO B BpaByIO pyICy HJIaTnII0By10 HCTJIIO, xopomo npol{a-
JIeHHyIO Ha IIJIaMCHH B BCpTHI{aJIhHOM HOJIO1HOHIIH (gaff YHHgTO?1 OIIIIH
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(IIJIaTIIBOBa11)
IIeTJIJ1.
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HpO6xy Mn3nnl);eM H 603LIMHHIIb1M naJTLr eM TOH MO
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I{ Ba CTOJI IIO ICJIaAyT). HCTJIeii Ha6HpaloT B npO-
6HpICe O)Hy ICanJllo II OCTOpO5ICHO Co 113BJIeHaIOT;
iJpafi npo6HpICH caeriia nplrn llraroT n B6JI11311 nJla-
MCIIH 3aICpblBaIOT npo6ICwii (He BbinyCHafI HOTJIH).
11ocJIC 3TOr0 Hpo61rpICy CTaBHT B niTaTnB, a OCBO-
GO 1I13 1orTCH Jicuoi3 pyHCOi3 6epyT 3a pe6pa npoA-
MOTHOO CTOHJIO.
HOTJIIO HpIHJIaAJIBaIOT H IIOBCpXIIOCT11 CTOHHa
H pa3Ma3bIBaIOT HpyF0BbIM1I ABH}ICCHHFIMH HarIJIIo
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MOAJICHHO XOpOnlo npOHCaJInBaIOT Ha IIJIaMCIIII, =ITO6bI
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BalOT HeCKOJIbKO AHOH B TepMOCTaTO. PaCTBOp MOSKOT AJIHTe3IbHOe
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIpH CJIOH{HOM MOTOAO oHpaCHJ4 HpenapaT oHpaHIIIBaIOT gByMH HaH
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
RHCJIOTOyCTOHtIHBbIC 6aF TCpHH HpHHHMaIOT Hpacxblft HBOT, oCTaJIb-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIOHH YBOJIHi1eHHH cyXOII C14CTOMM H HpH HOMOWH gHaC parMbl Him
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
3aBepxyTmTMII B Mapf0 HJIH BaTy). 3aTeM B cTepHJIH3aTOp HaJIHBaIOT
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B annapaTO Hoxa - CoCyge B;HJIHHgpHiOCKOII ( OpMbI C HerJIOTIIo
3aHpbIBaIoLT encn KPEIHIKOH H OTBCPCTHCM AJIH TepMOMeTpa. Ha AHO
annapaTa HaJTHB3IOT Bogy, BCTaBJIHIOT peHIeTIIaTylo 1OgCTaBKy H KJIa-
Pxc. 22. CymnJIbniIi3 1Hxa4i (Hem
HacTepa).
gyT Ha Bee CTep1Jln3yeMble HpeJ;Me-
TbI. Bogy nogorpeBaiOT 90 KHneHHa
(100?). 3KCn03HI vIH - 30 MHHyT.
OgxoipaTxaa CTepHJIH3a1[1H 3T11M
MOTOgoM He o6ecnetIHBaOT IIOJIHOFO
06cCnjTO5KHBaHHH, TaH KaR np1
3TOM y6HBaIOTCa TOJIbHO BereTaTHB-
Hble ( )OpMbI 6aHTepHIl, HO HO Cnopbl.
AJIH gOCTHHCeHHa 1OJIHOH CTepIIJI11-
3aI;HH TOKy'IHM napOM B03geI1CTByIOT
TpH gHa nogp}g (gpo6Ho) no 30 MH-
HyT. 3THM MOTOgOM CTepHJIH3ylOT
nHTaTCJIbHble CpegbI, KOTOpble HO
Bbigep?KHBaIOT HarpeBaHHe BJIHIe
100? (cpegbi c CaxapaMH, HeJlaTH-
HOM, MOJIOIIHMe).
C P H 3 a A CYXHM
IIa poM nog AaBJI0HHCM
(aBTOICJIaBH poBaHHe) go-
CTHraeTCf B C1IeunaJlbxoM anna-
paTe - aBTonJIaBC - gByCTOHHOM KOTJIO C repMeTHieCKH 3aKpbI-
BaIOn e11Ca KpbIIHKOH H MaHOMeTpOM. Mexcgy CTOHKaMH annapaTa Ha-
JIHBaIOT Bogy. B KOTCJI noMemaIOT CTOpHJI143yOMbIC HpegMeTbI; 3aHpbi-
BaIOT KpEIHIKy. HogorpeBaeMaa Boga 3aKHnaCT; Ilepe3 0TBepCTHH BO
BHyTpCHHCH CTCHKC aBToHJIaBa o6pa3yIOII[HCCa IIapbI HonagaloT
BHyTpb KOTJia, BbITCCIIHIOT 113 IICro B03AYX LIepe3 CIICIUHaJIbHbIH ICpaH,
KOTOpbIH IIOCJIO 3TOF0 3a.iipbIBaIOT.
gaBrIexne Hap B 0,5 aTMOCC epbl COOTBOTCTByCT TeMnepaType
110-112?, B I aTMOCC Opy - 119-120?. CTepHJin3auna npil 120? npo-
goJlllfaeTCH 20 MHHyT. B aBToxJIaBe o6eCHJIOHfHBaIOT IHTaTOJibxbIO
Cpegbl, nepeBH30gHbIfi MaTepna3 B MOTaJIJIHIIecRIIx Kopo6Kax -
6Hucax (614HTbl, TaMHOHbi H gp.).
TnIIgaJIH3aI;IIH - MCTOg gp06H0bb CTeplJ1H3agim. HarpeBaxne
xpOH3BOgHTCa B BOglIH0I11 6aHe nfH TeMHepaType 56-58? B TO'IOIIHC
6-7 gHeH: HCpBbI13 gCHb 2 data, B noCJICgy10igHe HIT - no 1 ilacy.
TaHHM 06pa3OM, CTOpHJI143yIOT 6eJIKOBbIO BelgeCTBa, He BblgeplKllBa1o-
HaHe HarpeBaHHe BbiHie 60? (KpoBaxaa cbIBOpoTKa).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HacTepmagnn - McTO) gaCTMHOII cTepHJIH3aI;HH (y6HBaIOTCH
TOJIbHO BereTaTHBHble (opMN 6aHTepHI3, CIIOpbI He Horr6aIOT). HaCTe-
pH3yIOT IIpH 75-80' B TeTieHHe 30 MHHyT C IIOCJIegyIOIIAHM pe3HHM
oxJia,H) eHlieM. B MHBOTHOBOI;TiecHOH IIpaHTHHe HacTepH3aqHH HIHpOHO
HdHOJIb3yeTCH PJIH O6e3BpeHfHBaHHH MOJIOHa HopoB, 6onbHbix Ty6ep-
HyJIe3OM H 6pygeJIJIe3OM.
B,HTaTeJIbHble epegbI. 1JIH BhIJXeJIeHHH 6auTepHaabHO1ft HyJIbTypbi
H3 HCCJIegyeMoro MaTOpHaJIa IIOCJIeAHHii BbICCBaIOT Ha IIIITaTeJIbHble
epewla. HCHyCCTBeHHMe IIHTaTeJH HIde cpeRbi 6bIBaIOT MHAHIIO, IIOJIy-
MHRHHC H HJIOTHble. Hau6owiee yIIOTpe6HTeJIbHbI CJIeAyIOH;He HcHyc-
CTBeHHble HHTaTeabHMe cpeAII.
1. Muco-HeHTOHHbII3 6yJI16OH (MIIB). PoBxsHbe mace, oCBo6o5Hj(eH-
Hoe OT HocTeg, H{Hpa H cyxourn IHI3, 113MeJibLIaiOT. MHcHok ( apm BbI-
Aep RItBaiOT 14-16 LIaCOB B ) BOI3HOM (Ho Becy) Horn 4 eCTBe AHCTHJI-
JIHpOBaHHOH BOAJI. HacTOH C MHCOM HHIIFITHT 1,5-2,qaca H f IHJMTpyIOT.
HOJiyTIeHHan H II) HOCTb Ha3LIBaeTCH M5ICHOH BOAOI.
MfICO-IIeIITOHHbIFI 6yJIbOH rOTOBSIT H3 MHCHOII BOAM + 0,5%
HOBapeHHOI3 CoJiH (5 r Ha 1 JI) + 1% IIeIITOHa (10 r Ha I Ji). Bee
BMeCT HHIIHTHT, yCTaHaBJfHBaIOT peaiwHlo cpeRbl (pH), (HJIbTpyIOT
qepe3 6yMaHCHMii (HJMTp, pa3JIIIBaIOT no IIpO6HpHaM (HOJ16oLIHaM) H
CTCpHJIII3yIOT B aBTOHJIaBe,
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
2. MIICO-IIdnToHHbIi3 arap (MHA) - IIJIOTHaH cpega. B MHCO-
rienTOHIILIH 6yJIboH A06aBJInI0T 3% arap-arapa, HOTOpbIII IIpII 110-
AOrPOBaHIIH pacIJIaBJIHIOT B 6yJILOHe. B ropsrueM BIIAC yCTaHaBJI11-
BaIOT pH, (J11JIbTpyI0T LIOpe3 BaTHO-MapJIOBbIH (HJIbTp, pa3JI11BaIOT 110
HOJI6o'maM (Hpo6IIpICaM) H CTCpIIJI113yIOT B aBTo1{JIaBe. HoCJIe CTCpII-
JIH3aI[rm IIpo611pI{H paCHJIaAbIBaIOT B HaHJIOHHOM IIOJIOHCeHIIH; CpeAa,
OCTbIBafI, CTaHOBHTCH IIJIOTHOII 11 HMOOT CHOIHCHHyIO IIOBCpXHOCTb.
3. MHCO-IIeIITOHHbIYI ?HcJIaTHII (MMH) - HJIOTHa5I CpeAa. FOTO-
BIITCH TaH Hie, IcaH H MHA. H MHB Ao6aBJIIIIOT 10-15% erica THHa.
B pacHJIaBJI0HHOM MH?H npOBCplHOT pealiu11IO CpeAbl, ())IIJIbTpyIOT B
rOpH1ICM BHAe, pa3JIHBaIOT IIO IIpo6IIpIiaM 11 Ap06HO CTCp11JI113yIOT TO-
HyTFIIM IIapoM.
4. HoJIyawgEnII arap. H MHCO-IICIITOHHOMy 6yJILOHy A06aBJIFHOT
0,25% arap-arapa. Aaneo IIOCTy1aIOT TaR Hie, HaR IIpII H3roTOBJIeHIIH
MHA H MHiR.
5. HOIITOHHafI BoAa: H AIICTHJIJIIIpOBaHHOII BOAC A06aBJI210T 0,5%
XJIOp1CTOrO HaTpa H I% IIeIITOHa. CMecb HHIIFITHT, ()IIJILTpyIOT L1epe3
6yMaaaiblfl O111JIbTP 11 CTepIIJIH3yIOT B aBToICJIaBe.
6. CpeAbl C yFJIOBOAaMII H 11HA11HaTOPaM11 AHApeAa. CpeAbI C yr-
JICBOAaMII IIPIIMC11f1IOT IIPH 0npeAeJIeH1111 6IIOXIM11tIeCHIIX CBOIICTB MII-
npo6oB. B IIX COCTaB BXOAfIT IICIITOHHaf BoAa + 1% yrJICBOAa (rnio-
Ho3a, JIaHTo3a win Ap.) + 1% HHAHIiaTopa AHApeAa. Bee BMCCTe
Ap061I0 CTOPIIJIII3yIOT TCHY 11M HapoM. HHA11HaTop AHApeAa COCTOIIT 113
( yHCIIHa Hiic oro - 0,5 P, 4-IIp01[eHTHOrO paCTBopa OAH0r0 HaTpa-
16 MJI If AFICT11JIJI11POBaH1IO1'1 BOAbI - 100 MJI.
7. CLIBOpoTounbIII 6yJILOH 11 CbIBOpOTOIIHbIH arap. H CTOpHJIbHLIM
IIIITaTCJIbHbIM epeAaM - MHB H paCIIJIaBJICHHOMy - MHA Ao6aB-
JISIIOT CTCPHJIbI30 IIOJIyIICHHyIO HPOBHHy1o CbIBOPOTHy J1OIIIaAH B HOJIH-
ueCTBe 5% H 06LCMy CpeALI.
8. HpOBIIHon 6yJIbOII II Hp0BHH011 arap. H paCIIJIaBaCHHOMy
CTCPI,lJlbHOMY MHB if MHA if oxJIaHiAeHHOMy IIPHMepHO AO 450 Ao-
6aBJIFIIOT CTCpIIJIbHylO A4H6pHHHpOBaIIIIy1O HpOBL JIOIIIaAIr IIJIH 6apa-
Ha (IIpnMeH2I0TCa AJIH OHpCAeJI(,'HHH rCMOnIITHTIOCIiIX CBOHCTB 6aH-
TepIIu).
9. MonOHO (IIpoCTOC). CBeHide HOpOBbe MOJIOHO 06e3HuIp11BaIOT
if cJICrHa IIo nwna'FIIBaIOT AByyrJIOHIrCJIOfI COAOII. PCau1 HIO CpeAbI
OHpejOJIrIIOT 110 acrlioMy II0c11HCH111O JlaliMyC0B0i 6yMaamlf. CTCp11JIII-
3yIOT Apo6HO TOHy%1HM napoM.
HpoMe OIIHCaHHbIX, CyIILCCTByI0T OILe CpOALI cilegnaJILHLIe AJIH
BbIpaLI[HBaHHH OTACJILHLIX BHAOB 6aHTep1111 (HnLIIIbie epeAbI HOTpOBa
11 HeTpaHbflHII, rJI119ep11IIOBble H HapTO()leJrbHble, ne'ICIIO'IHb1e II AP.).
Onpege1eIIne peaiaiin cpe;Abl (pH). HpH 113roTOBJIeHII14 II11Ta-
TCJIbHbIX CpCA Ba)IlHO yCTaHOB11Tb IIX peaHu11lo (pH), TaH I{aH 113-
BCCTHO, LITO AJI1 pa3BHT11H JIF06oro BHAc M11Iip00praHH3Ma CTOHOHb
HIICJIOTHOCTII HJIH II1eJIOiIHOCTH CPOAbI IIMOCT CyH eCTBe11HOe 3IIagIOHHe.
M c T 0 A M H X a a Jl If C a. HoMIIapaTOp MIlXaaJII1Ca npeA-
CTaBJIHCT co6ou faIu11H c xa6opoM IIpo6HpoH, coAepaxamfix paCTB0p
BCIueCTBa-HHAI1KaTopa, ABCT HOTOporO B xwEAOII IIpo6Hpue 000TBOT-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CTByeT onpeAeJlexxoH pearl;HH cpeAbi: HHCJIOH (pH=5,7 HJIH 6,4),
HeuTpaaibxou (pH=7,O), cJ1a6o IAeJlouHOH (pH=7,2-7,4) H HieJiornon
(pH=7,8-8,2). Aim OIIpeAeJieHHH peaRwHH B Hpo611pHy co CpeRoH Ao-
6aBJIHI0T paCTBOp rOTOBOro HHAHHaTopa. OHpaCHy CpeAbi c AO6aBJIeH-
HbIM HHAHHaTOpOM CpaBHHBaIOT CO CTaHAapTHLIMH paCTBOpaMH B IIpO-
6Hprax; HoHa3aTeJib Hpo6HpHH HoMnapaTopa, CoBHaAaIome%i no oRpa-
CHO C I;BeTOM HCCJIeAyeMOH CpeAbl, H yHa3biBaeT CooTBeTCTByIOwyIO
peaHnHio.
TexHHHa noceB.a 6aHTepuaalbHblx IynbTyp Ha HcxyccTBeHHble nH-
TaTealbHble cpeAbl. HpH HOCOBC H3 HaT0JI0FIIgOCHOro MaTepiaiia
(HeLIeHH, CeJIe3eHHH) UOBepXHOCTb opraxa Hpl?HHraIOT HarpeTbiM Ha
HJIaMeHH HpH?HHraTeaieM - McTaJTJJHYeCHOI3 HJIaCTHHHOI3 (HIHaTeaieM).
B HpaByio pyHy 6epyT CTeHJIHHHy1O HHHeTHy HaCTepa C TOHHO OT-
TIIHyTbIM 3aHaHHHbIM HOHB;OM, B JleByio - ABe Hpo6HpHH C HHTaTeJib-
PBC. 25. KoMBapaTOp H Ha6op CTaBAapTHbIX pacTBOpoB HHAHHaTopa
(Ho MxxaaJixcy).
HbiMH cpeAaMH - MIIB H MIIA. OTJIOMHB HOHOB; IIHHeTHH B6a1H3H
nJIaMeHH rOpeJIHH, OCTOpO?HHO HpOHaJILIBa1OT eio HOBepXHOCTb THaHH
HCCaIeJyeMOrO opraxa B McCTe, HPH?HHCeHHOM IIlnaTeJieM, H HaTHrH-
BaIOT ATOM HeMHOrO MaTepHaJia. He BbinyCHan nHHeTHy, M113HHAeM 11
6C3bIMHHHbIM naribileM iipaBOH pyHH BbIHHMaIOT np06RH 143 Hpo6HpoH,
yAePMIIBaeMbIX HaHJIOHHO B JIeBOH pyre C 06paWeHHbIMH B CTOPOHY
FOPCJ1HII 0TBepCTHHMH. IIHneTHy BBOAHT B Hpo6HpHy c ?1HAroH CpeRoH,
caierua HaTHrHBalOT HeMHOro ?RHAHOCTH H 3aTeM iIaCTb Ha6paHHOro
BbIJIHBaIOT o6paTH0 B Hpo611pHy, a OCTaJlbxyIO LiaCTb BHOCHT B Hpo611p-
Hy c arapoM, opomIafi HocJIeAHHH. Hpo6HpIH 3aHpblB IOT 11 CTaBHT
B TepMOCTaT HPH TeMHepaType 37-38? gaff BbIpallUHBaHHH HyJlbTypbI.
HCHOJIb3oBaxxyIO HHHeTHy OHyCHaIOT B paCTBOp Hap60JIOBOH HHCJIOTbI
Hair Hauoro-JIH6o ApyrorO Ae3HH( IITAHpyI0Hlero BeWeCTBa.
IIpH BbICeBO 6aHTepiiaJlbHOH ryJlbTypLI H3 oAHOH IIpo6HpHH B Apy-
ryio 6epyT B JIeByIO pyHy ABC HpO6HpuH- OAHy C 3acesaeMOH HyJlb-
Typol, Apyryio CO CTepHJIbHOH HHTaTeJlbxoF CpeRoH (o6e Hpo6HpHH
Aep?raT HaRJloHHo, HpO6HaMH B CTOpOHy HJiaMeHH roperir i), a n
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
IIpaByio - 6abTOpHOJIOrIMeC11y1O IIeTJIIO. noCJIeJIHIOIO IIpOHaJIIIBaIOT
iia HJIaMCIIII, Hpanoi py1{OH BbIHHMaIOT IIp061CH H3 Hp06Hp0I{; B3HTYIO
IIUTJICII HauJIIO H3 Hp06HpHII c HyJlbTypOII IIepeHOCIIT B upycyIO Hp06IIpHy
Puc. 26. HOCCB B upo611pHy H Ha HJIacTHHHaTbIK
arap B qauIHy.
co epegoii. ECJIII cpega SHIIgHal, BBCAOHHYIO HCTJIIO C ImuieH OHyHaIOT
B MHJ;HOCTb; eCJIH cpcja IIJIOTHaII, HOTJICII HpOBOjIIIT CJICrHa no IIo-
BCpXHOCTH COJIOp?HHMOPO IIpo6HpHII CHH3Y BBCpX. IIpo6IIpHII 3aHpbl-
BaIOT H HOMCHIalOT B TCpMOCTaT.
4T06bI 143 CMOCH AByX WITH HeCHOJIbHIIX BHJIOB 6aRTepIIII B LI-
AeJIHTb LIHCTyI0 HYJIbTYpY HaWAOPO BIIJIa, IIpHMeHHIOT
MCTOJI HJIaCTIIHTiaTblX HOCCBOB. Hamm CMeIIIaHHOH HYJIbTYpbI Ha-
HOCIIT IIIIIICTHOH Ha HOBOpXHOCTb mnco-HeIITOHHoro arapa B *IanJHe
IIeTpII. IIIHaTeJIeM OCTOp05HHO pae paIOT Hamno 110 IIOBCpXHOCTH
arapa. 3aTeM 3TIIM We IHHaTCJICM pacTHpaHHe HOBTOpIHOT BO BTOpOII H
CJIeJIyI mux LIamICax (go 5-6 TIaIIIeK HoTpl). tIamHH noMewaloT
B TepMOCTaT Ha 24-48 LIacOB. Bee MaHHIJ JIHL 1H1 BbIIIOJIHIIIOT B CTe-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
pHJIbHbIX ycrioBHHx. B HocJIeRHHx qam ax POCT 6aHTepHH noJ1y*iaeTCH
B BHAe OTJ[eJIbIIMIX HOJIOHHFi, 6JIarogapH ileMy HpeJ[CTaBJIHeTcH B03-
MO?HHOCTb nepeceBa 3THX HOJIOHHH Ha IIHTaTeJIbHyIO CpeRy B IIpo-
611pHy.
McTo M HyJIbTHBHpOBaBHIi auaapo6oB. AHa3po6Hbie MHHpo6b1
BblpamIIBaIOTCfi 6e3 J;OCTyna CBo60J;Horo aTMoe~epHoro HHcnnopoAa.
H alaapo6aM OTHOCHTCH BO36yAHTenIII ra3OBOH raxrpeabl, 3JIoxa'Ie-
CTBeHHOrO oTeHa, CTOJI6HHHa, 3M(H3eMaTO3HOrO Hap6yHHynna H Ap.
H 3 H q e C H H H M e T 0 g C03gaHHf1 aHaapo6HbIx yCJIOBIIH.
3acefrHHb1e aHaapo6HbIMH MIIHpo6aMH IIHTaTeJIbHmIe epe) LI IIOMeigaIOT
B ciicgHaJIbHNIH arnapaT ApHCToscxoro (HJIH B CTeHJIIIHHLIi`i 3xCHHa-
TOp), repMeTHLIeCxH 3aHphIBaIOT ero H BbIHa'IHBaIOT B03JAYX HacocoM.
BHyTp1T aIIHapaTa C03J;aeTCfi 6ecHHCJIopo)[HOe IIpOCTpaHCTBO. AIIHapaT
HJIH 3HCHHaTOP IIoMeIUaIOT B TepMOCTaT.
XIIMHLIeCHHii McT0 A. IloceBbi aHaapo6HLIX Hy3IbTyp
noMell aIOT B 3HCHHaTOp Ha IIOJ;CTaBHe; Ha A HO ero HOMCWaIOT IIHpO-
raJiJioa H meJIOgb H 3axpbihaiOT IIJIOTHO HpbIIIIHy, IIpeABaPHTeJIbIIO
cMa3aB ee span Ba3e3IHHoM. PeaHrIIII McHHgy IIIIporaJTJIO7IOM H u eao-
LibIO COIIPOBomAaeTCH IIorJIOIIjeHHeM HIICJIopo1 a, BCJIeJ[CTBHe'IerO B rep-
MCTHT1eCHH 3aHpbITOM 3HCIIHaTope c03gaIOTCH aHaapo6Hble ycJIOBHH.
B Hoaorif gecHHft MOTOR ocHoBaH Ha IIPHHI[HIIe co-
BMeCTHOrO BLIpaII;HBaHHf1 aapo6HoIT HyJlbTypBI c axaapo6HoI3, xorga
CBO6OWJbII3 HHCJIOpOA HorJIomaeT HepBafi xyJibTypa, Co3J;aBafl ycJIo-
BHH axaapo61w3a AJIfi BTOpoIT. AJIH JLOCTHH{eHHfI 3TOrO B rJIIOHO3HO-
HPOBHHOM arape, Haxo)(HweMCHI B iIaBIHe HeTpH, IIocpeJ[HHe CTepHJibHO
BbIpe3aIOT y3HyIO HoJlocHy, pa3AeJinB IIOBepXHOCTL Ha J];Be IIOJIOBHHhI.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ha OAHy 113 IIHx 3acenaroT a3po6Hylo HYJlbTypy (r iiiiioHHafi win coH-
IIaH HaJrovxa), a Ha Apyryio - aIIaapo6Hyio. Nlcar;yxa Ha HOBepXHOCTb IJIOTHOH HHTaTCJIbHOH
cpejjbI (CM. rJlaBy VII).
B IIaCTOHuiee BpeMFI caHHTapllasl 6aHTepHO-
JIOrHH o6oraTHJlacb cneJulaJIbxbIM npl6opoM
HpOTOBa, ROTOpbIII gaeT BO3MOxcHOCTb 6oJIee
TOgHO yCTaHOBHTb HoJIHLIeCTBO MHHpo60B B CAH-
HHIIe o6,beMa B03) yxa. LIaHIHy c 1IHTaTeJIbxoI3
cpeJloli HoMema1OT BHyTpb annapaTa. Ha IloBepx-
HOCTH Cpej[bI CcejIaIOT 6aHTepHH 113 aBTOMaTH-
*IeCHH BTHPHBaeMOrO B03J.IyXa. OcO6bIM CMOTLIHHOM
OTMeTIaeTCF1 TOLIHOO ICOJIHtIeCTBO nponycHaeMoro
B039yXa 3a JIIO6oH OTpe30H BpOMeHH. 3aTeM
ualuHy Co cpeqoli (arap) BbIAOPHCHBa1OT 24-48 ua-
COB B TO MOCTaTO H HPO143BOAHT n0j1;C'ICT BbIpOC-
IHHX ICOMOHHH.
B a H T 0 p 1 O J I o r H L I e C H o e HCCJIC-
j> O B a H H e n o *I B bi. B BOTepHHapiIOIi upaH-
THHe 6aHTepIIOJIOrugecHOe HcCJIej[OBaHHe IIOLIBbI
HpHMeHHeTCH pej{HO, rJIaBHLIM o6pa3OM jIJIH
OHpej1;CJICHHF[ HaJIHLIHFI naTOreHHbIX cnopoo6pa-
3yIOn411X MHHp060B (CH6HpCI of H3Bbl, CTOJ16HFIHa
H j{p.). ITpo6bl c06HpaIOT CneIIHaJIbHbIM McTaJI-
JIIIMCCHHM HOJIbIM 6ypaBOM Ha pa3HbIX rJIy6HHax. OTBOIHOHHOC HOJIHLIC-
CTBO IIOLIBhI (3--5 r) 3aJIHBaIOT CTepHJIbHLIM IJH3HOJIOr1LI0CHHM paCTBO-
pOM HOBapCIIHOH COJIH, THIaTeJIbHO BCTpHXHBaIOT, HpOrpCBa1OT 30 MHHyT
Hpn 80? (,gJIFI YIIW1TOH{0HIIfI BCPOTaTHBHbIX IOM 6aHTepHH) H 3aTeM
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
pyl(eHHH cnel;H(H*IeCKHX o6pa3osaHnn-BKJIIOL1e-
p
(npH 6eHleHCT'Be H Ap.) IIpHMeHHeTCH McTOA MH-
-- ----------- -- --n- - um
IIPHCyTCTBHH IX B opraHax CyAHT HO pe3yJlb-
TaTaM 6HOJIorlHecxoi3 npo6M: BHpyccoAepma-
IgHM naToJlorniieciHM MaTepiarIoM 3apa?KalOT
BOCIIPHHMLIHBOe K AaHHOMy 3a60JIeBaHHIo ?KHBOT-
LTX 3a6oJIesannI3
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LIecHne oco6eHHOCTII (Hepa3JlnHHMOCT16 B o6LIHHLIX CBeTOBLIX MHKpo-
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HHl3 (TeH1ell) B HCCJIeAyeM0l THaHH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIIIIOT, COO;jIIHHB ee C HacocoM. HHJ[KOCTL 113 IIOJIOCTH gHJI11TI pa,
npoIJ 1I ICepamttnecICHC CTCHICH (HJIbTpa, C06HpaCTCH B I{oji6e.
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CLIBOpOTKa). DTOT McTOA OCHOBaH Ha B3aHMOA0iiCTBHH aHTHreHOB CO
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B TOM, LITO Haxo JIlljaflcH B Hpo6HpRe pa3Begexxaa (f u3HOJIOrHLIecHHM
paCTBOpOM HpOBHHa5I CbIBOpOTHa
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pa3JIHiIHOH BOJIHLIHHbI (CH3IeeHHbIH aHTHreH). Hpii OTCYTCTBHH arrJIIO-
111
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
THHaWIIH HMCIOWHIICn IIa AHC rlpo6HpHH ocaAOK B BHRe nyrOBnLI JICI'Ho
1)a3611BaOTCH HpH BCTPHXHBaHHH, BbI3bIBaH paBHOMepHOc HOMyTHeHHe
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pa3pa6OTall HJIacTHHTiaTbIH MOTOR peaI{gilu arrJIIOTIIHOIWII. 14C-
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c HpacHoH reHJHaH-BHOJIeT B AO30 0,03 MJI. CbIBOpOTHy H allTHPCII
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paCTBOPOM ((H3HoJIorI1 eCH1ii paCTBOp C 0,5% Hap60JIOBOH HHCJIOTbI).
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BHJIO, CTaBHT HOHTpOJIb, T. 0. HCCJIOAyIOT co CHeIH(JHileCHHM aHTHre-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HoM 3aBe)OMo n03HTH13HyI0 (HpeIIHIIHTHpyIOHIyIO) CbIBApOTHy H HOp-
MaJlbHyio. B IIepBOM cJiy*iae AOJIHSHa IIOJIy iHTbCFI IIOJIoa riTeJIbHan
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poro pnAa. B mix me Ao6aBJISIIOT IIO 0,5 MJI HoMHJIeMeHTa, pa3BeAeHHOro
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6apaHa, pa3Be)eHHO1i (H3HOJIOrHLIeCHHM paCTBOpOM 1 : 40, H IIo 1 MJI
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3BaBIIIHM IIOJIHbiI3 reMOJIH3 3pnTpOIIHTOB, oxaaaJiocb pa3BeAeHHe ero
5 M. C. raHayIIlxaa 113
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B Hpo6Hpxe 1 : 2000 (npH HaJIHiIHH reMOJI113a B npeAMAylIx pa313e-
ACHHHX 11 npH OTCyTCTBIIH ero B LIOCJICAyIOM11X - I : 2500; 1 : 3000).
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0,49 MJI). B KaSiAyio npo614pRy Ao6aBJIHIOT CTOJIbHO [ H3HOJIOruTIeciOro
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
aw ll13eMaToaHOM Kap6yHHyJIe; Bo36y) HTeJIb 3TOro 3a60JIeBaHHA o6-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
C. H. BbIHICJIeccHHM 61,l.no yCTan0B,neno 3apa?Keane canoM xHlHbIx aaepeii
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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3a6oJICBaHIIe. BOJIbHb1e }HHBOTHblO BMCCTC C Bblije3IeHHHMII 143 HOCa,
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10* 275
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
KJIHHIIIICCHIIC HPH3HaIUI 60JIe3HII. I4HHy6aIIHOHHbIM nepnoA np1I
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pdJW11X CJIy'IaHX HpYMHbIMH HpOBHHb1M14 11aTHaMM. TaHMC 7He HpoBoH3-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIHHHHH HMeIOT McCTO Ha eepo3Hblx o6oJlo*IHax rpyRHoH H 6pIOIIIHOH
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pyIOT 3-IIp01;eHTHbIM rOpnLIIIM paCTBOpOM JIY[3OJla, HpCOJIIIHa, xap6o-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIOBOH I{IICJIOTLI HJIH 10-HpOI[eHTHbIM paCTBOpOM HI3BeCTI{OBOro MO-
Jrol{a. B ica9CGTBe emeLk I(J)H9CCI{Oro Hpo(JHJIaKTII9eCHOF0 CpeACTBa go-
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r0II0JIy9HOC no naCTOPCaJIe3y HPOJIHl{OBOA4OCHOC X03HHCTBO o6'bHB-
JIHeTCI1 6JlaronOJly9HbIM 9epe3 ABe HCAeJIII HpH OCTpOII H 9epe3
20 AHCH IIpH XpOHIVICCHOH (OpMe naCTepeJIJIe3a, IIOCJIO HOJIHOIO
npenpaweian 3a6oJIeBaHHI1 IIJ111 BbIHya I eHHOro y6oa H TigaTOJIb1IOH
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6paaOBaII Ty6epKyJIe3Horo CHOTa B MO.IOAOM Bo3paCTe (a BMCCTC C 3T11M
VMCBb1BC11IIC CpejjHCH HpOAOJUHHTCJibHOCTH HM31111 ISpylHOPO poraTOro
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BoCHpIIIIM9IIBb1a Ty6epayJIe3y BOO BIIAbi AOMBAIHIIX ?ICIIBOTHMX, OAHaRO
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
tiallwe Apyrnx nopaxfaeTCH HpynHbli3 poraTblil CHOT, 3aTeM CBHHJH,
a TaHHfe HTIIIIbI. H Ty6epHyJIe3y BOCnpHHMqnB H 9eJIOBeic.
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losis OTHpbIT HOXOM B 1882 r. OH HMeeT ()OPMY TOHKOii CTpOfIHOI3 na-
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5,0 MHHpOH, InHpuHa 0,2-0,5 MHHpoHa. B naTOJ1OrnileCHOM Ma-
TepuaJie HJIH BhIAejIeHHbIi 113 CTapbxx HyJIbTyp Ty6epKyJIe3HbIIi MHHpo6
LIaCTO npeACTaBJIFIeTCFI Han 6M COCTOfIWIM H3 OTACJIbHbIX 3epeH. B no-
CJICAHee BpOMH CgIHTaiOT AOKa3aHHbIM, 'ITO Ty6epHyJfe3Hag naJlogia
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Pile. 75. Ty6epxyrreaHbie 6aiiTepfhi.
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TeMnepaTypa AJIH HYJIbTHBI1 OBaHHH BO36yAHTeJIfI Ty6epiynle3a
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
37---38?, 110 OCT pee MO?KCT HpOHCXOHTb n rlpn 30-42?.HoTIOHnH Ha
IIHTaTeJlbHOii cpeAC IIo}113JIIIIOTCn JuHUlb MOPe3 1-2 ne e in IIoc ie 110-
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(B. tuberculosis typus humanus), 6hIL1rtIi
(B. tuberculosis typus bovinus) IT rITH-
qHii (B. tuberculosis typus gallina-
ceus), KOTOPMC CJIeAyOT paccMaTPHBaTb
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IIOJIytIHBUIHOCH B P03YJIbTaTC AJI1iTeJ1b-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIe3Horo Hpolzecca. OAHOKpaTlIan Ty6epnyJIe3Han HHI enqaa MasmbIMH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HC 6LITb TaHHX IIpI13HaHoB, KOTOpbIO yKa3blBaJiH 6bI iia Hammite
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
HbIX, IfpyrJIblx o6pa30BaHITIi (HHeMtIy?ISHHqa), Co,i[cp1raWHX OTACJIb-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
noTopafl n03BOJIflCT Bb]OBHTb BCOX HUIBOTHMX, 3apaHiOHHblx Ty6ep-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
V CBHHCII BIJ TPHKO?KHaI Ty6epByJIHHOBan Hpo6a HpOH3BOAHTCH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
11pH Ty6epKyJle3e Kyp 6oJIbHnIX HTHA y6HBaIOT, a OCTa3IbAblx CIi-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BOJILHO 6LICTpo HapacTaeT; LIacTb 60JIbHBIX BbI3J;opaBJIHBaeT, a y MHO-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HaM AO 100 MJI, B3pOCJILIM CBIIHLHM 100-150 MTh Ho OTJ[eJ hn},IM JTaH-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
A03M Ba1gnubx coCTaBTIRIOT: AJIH IIopoCHT-COCyHOB e 10- Ao45-AHeB-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
X03HIICTBO (cepMy, CHOTHbIyJ J(BOp, CBHHapHHH H T. J(.), Tj[e yCTa-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
rriaea XX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IHOHHbIX Ma3HaX OTMeKaCTCB 3OpHHCTOO CTpOeHHe MHHpo6a; IIOMIIMO
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Hc1BOTHEIX IHOpCTbIO geJIaeT 3TOT cII0006 3apameHH31 canoM McHee
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XaTeJIbHble nyTII.
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iiagajio MOHCeT, IIO galHbIM OqHHX HCCJIegOBaTeJIeH, IIpOHIIHaTb gaimme
ilepe3 JTHM(J)aTngeciHe HyTH CJIH3IICTOpI o6oJIOLIHH HOCOrJIOTHII. Z(py-
rHe noJlaraloT, qTO B HpOBb CanHOI MHRp06 IIouaAaCT ilCpe3 CTeHICy
HHIHetIHnna, HOTOpan IIpH 3TOM O6bhIIIO OCTaeTCH HCn3MeHeIIHOII. B 3a-
1311CIFMOCTII OT HOJIHqCCTBa H BHpyJIeHTHOCT1 BHCApHBIIIeroen B036y-
J[HTCJIII H o6H[ero COCTOFIIIIIH OpraHII3Ma CaIIHble nopaxceHnH MOryT
J1OJIyYHTb 6oJICe 1JIII MCHCC MHO?HeCTBCHHbIH XapaRTep.
LIaH{C BCerO canoM IiopaHCaIOTCFI JICPHIIe, rAe CaIIHble H3MeIICHnfi
BCTpeilalOTCH HO`ITH B 100% cJIyLIaeB; A0BOJIbHO 'IaCTO OHH JIOHaJIn-
3yIOTCH Ha CJI113HCTOn o6o jogxe Hoca, Ha Home, B JIIIM()aTHLIeCHHX
y3Jiax II BO BHYTPCHHIIX opraHax (ne'CHII, CeJIe3eHRe). HOJ[ BJIHHHIICM
caHHhIX MHHpo6OB B03HHicaIOT McJlRFIC y3CJIHH, B 06pa3OBaHHH HOTO-
pbix IIpIHHMaIOT yuacTIIe 1JIeTOLIHble 3JICMCHTbI. Y3eJIHH B I(CHTpe
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TaHIIM o6pa30M, IIOJIytIaeTCH 06bI3BOCTBJICHHbIII canHOI3 y3e.IoH. Norga
.y3eJIOH He HHHancyJIHpyeTCH, B03MO}RHO gaJ1bHeIIllee paCnpoCTpaHe-
HIIe canxoro IIpogecca. ECJIH y30JIOF, HaxoJ;HTCH, HaupuMep, B cTenne
6ponxa, canxoII MHHpo6 LIepe3 CTCHHy Oro MOXCeT HonaCTb Ha IIOBepX-
HOCTb CJIH3ITCTOI3 o6onno'HH H OTTy a CO CJIII3blO Hapy?Hy. BMeCTe
C TeM HaxOJ.[HIIUHeen Ha CJTH3HCTOI3 6poaxoB CaIIHble MHHpo6bl MoryT
IIpH BAbIxaHHH nOnaCTb B aJlbBeoJlbI, coagaBaa II B HIIx canHble IIHeB-
MOHHLICCHIIe 4 ouycb1.
ECJIH B TOR HpOBn cpa3y nonagaoT 60JIbIHOC ROJIIIMeCTBO CaiHbIX
naJiogei, B03MOMHO OJJ;HOBp0MCHHO0 o6pa3OBaHHe oLIeHb 6oabmoro
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
xorn1geCTBa cauHbix yaeJIROB B JIernnx (MIIJInapHblll can) n B gpyr1X
opranax (Ha cJIH3ncTOn Hoca, Ha no?ne).
YcnoBn i, cnoCO6cTByIOII;ne pacnpocTpaneHnio cana. OCHOBHLIM
nCTOgHHHOM cannon KH4M iin HBJIgOTCH 60JIbHai CalOM JIOHIaAb,
HOTopaB, B 3aBIICHMOCTH OT XapaHTepa npouecca, Mo neT BbIAeJIHTb
MIIHP060B C HCTOYeHHeM I13 HOCa, npn I bipnaHbe n HaIIIJie H3 JIerxnX
H C rHOIIHbIM CCHpeTOM HOHCHbIX H3B. TJIaBHOe 3HaneHHe B nepeAa'e
Cana HMeeT HOCOBOe IICTeueHne, oAHaHO BbIAeJieHHe 3apa3HOP0 Ha-
YaJia npn Hume H H3 HOHfH1.IX F13B TaHHie MOMeT CJIyHSlTb IIpn'IHHOH
paCIIpOCTpaHeHlH 6oJIe3Hn.
3apa}nenne name BCero HacTynaeT IIpn noJIb3OBaHnn 06MHMH
nopMyIIIKaMl, BOAOUOIiHbIM1 BeApaMII n TOp6aMn, HorAa HopM H Boma
3arpJI3HHIOTCH BbIAeJIeH1HMl 6OJIbHOn JiomaAH n 3aTeM nonagaIOT
H 3AOpOBOn. HOCOBbIM HCTe'IeHHeM H BbIJ[eJleHneM HOHUIbIX H3B iIaCTo
3arpH3HHIOTCH npeAMeTbI yxo a n cnaprxcennH, HoTopble CTaHOIIHTCH,
TaHHM o6pa3oM, IIepeHOCnnHaMH nn4eHgmi. 3apanceHHLle CTOHJIa
nrpalOT poilb nepeJ[aTnHHOB nHIJ2eHljnn, ec in nocrie 60JIbnoll JIoIIIaAn
B ee CTaHOH BBOAHT 39OpOBy10 JiomIIagb, nomb3yIomyloc1 HopMymnoil,
113 HOTOpOH HOpMHJin 60JlbnyiO JIOIIIagb. B 6JiaronOJIyilHOe X03HIICTBO
can 06bIHHOBeHHO 3aHOCnTCH BHOBb IIOCTynaiolIUIIMn 6OJIbHbIMH JIo-
IIiaAbMII, nipw1ieM CHaqania 3a60JI0BaIOT CTOHn[ne C HHMII DO CoCeACTBy
jiomaJ;n, a 3aTeM can IIOJIynaeT J[ajIbHenniee paCIIpOCTpaHeHne.
YCJIOBneM, 6JIaronpiuTCTByIOH9PM pacnpOGTpaxeHnio caIIHOn HH-
4eHunn, Cny?HHT cnynennoe COJJtep?HaHne JIOniageli, oco6eHHo eCJHl
OHII HaXOAHTCH He Ha npnBH3H n nMeIOT B03MO1HHOCTb CBo6oAHo o6-
maTbCH Apyr C ApyrOM. 06mile HOPMyfHP II BoAorlolHMe Begpa gacTo
cJiyxcaT IIpffnHHOII pacnpoCTpaneHIIH cans Ha 3ae3ncnX ABopax. 3a-
pa neHne B03M0?HHO npn nOJlb3oBaHnn o61gHMH BOAOIIOIIHLIMII HOpbI-
TaMn. Oco6oe 3IIaLIeHHe B pacnpOCTpaHeHHH Cana IIMeIOT caimbie
XpOHPHII, HOTOpble, He BbIHBJIHH HHHaHHX HpH3HaHOB 60JIe3Hn,
MOryT rOgaMI3 pacceHBaTb MHHpo6oB. B AOpeBOJIIoA130HHOe BpeMH,
norAa 6opb6a c canOM B Poccnn orpaHli'IPBaniacb TOJIbHO yHHiITOMe-
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Hax YHpannbl, B npeAeJlax TenepemHMx rpa1H1 Hyi16bllneBeRoli o61IaCTH H
Ha3aXCnOH CCP, OVIaCTH B CH6HpH). 06ancHenne 3TOMy cneAyeT HcnaTb,BO-
nepBbIX, B RJIHMaTHUeC HX ycnOBHBX, co8J[aIOIUHX BO3MOHiHOCTb XpOHHileCKOTO
TexieHHfL cannoro npouecca. CanHbie xpoHHHH, B CBOIO O`IepeAb, OCTaBaHCb He-
BuIHBJIeHHbIMH, pacnpocTpaHH.nH Hn(Ieno1IO. BO-BTOpbNX, yxaaaHHbie pallOHrl
6biJIn B OCHOBHOM HOHeBOAneCHRMH, C HpyHHbIMH nyJIaInxnMM H IOMeL PHb1MH
HOHIILIMH X03HLiCTBaMn, rAe can R CRAY 3TOrO noJIyYaJI 6oraTy1o noiBy AJig pac-
npocTpaHeHHH.
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.cTH)Hen1H Haynn B o611aCTn J{narnoCT1Hn cHpbITLIX 4OpM 3TOFO 3a-
60JIeBaHIIH.
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IIpn cane HenpOAOJinfnTeJIeH, 'qTO IIOATBepHEAaeTCH nCHyCCTBeHHb1M
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
~apaxtenIIeM norAi nepBbte nogieMbl TeMnepATyptI perncTpnpytoTe
Ha 2-8-ii geHb Hoene 3apa neHnn. Hpu CupbITOM, He3aMCTHOM TO-
LIeHHH B YCJIOBIIJIX eCTOCTBOHHO O 3apa?neHHH 3TH nepllbie HOA'beMbI
TeMnepaTypbI 1IaCTO ycxoJIb3alOT OT Ha6rno eHHH, HO 3T0 He AaeT
OCHOBaHHH rOBOpHTb 0 I;JIHTeJIbHOM HHKy6aI;H0HHOM nepnOJ[e.
Ho XapanTepy TetieHHH can MOH T 6bITb OCTpbIM H XpOHHHeCKHM.
B no aBJIHIOII[eM 60JIbIHHHCTBe cJlyiIaeB OH pa3BIIBaeTCH y 7iomageII
Kan XpOHHLIeCKOe 3a6oJIeBaHHe, 6e3 naKux-JIH6o IIpH3HaICO-B, KOTOpbIC
yna3bIBaJIH 6bI Ha HajIngiie Cana; IIOCJIeAHIIII yCTaHaBJIHBaIOT JIHHIb
IIyTeM gIIarHOCTHgecHHx HCCJIegOBaHHI3 MaJIJIe1HOM II peanuuei cBH-
3bIBaHIIH KOMHJIeMeHTa. OCTpNIA Can, B 3aBHCHMOCTH OT BblpaHCeHHOCTH
KJIHHHgecnoI3 KapTHHLI, ) eJIIITCH Ha HOCOBOII, KOSKHbII3 H JIerOLIHbIH.
Heo6xogHMo HMOTb B BRAY, WO
3TO JZCJIeHHe yCJIOBH0, Tan nan
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a HOCOBOH H HO?KHbIH can MOryT
BCTpeilaTbCH OAHOBpeMeHHO.
HpII OCTpOM H 000BOM
c a n e Ha6JIloJgaIOTCH HOBbHHeHIIe
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Hb1I3 JIBM4aTWIeCKIIft y3eJI IIpH cane. II pacnagalOTCH, IIpOBpaIIIaJCb B
II3BLI. H3BbI MOryT yBCJIHiInBaTb-
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rHOI3HbII3 cenpeT, HHOrga c np1MeebIO KpoBH. HpOB;000 B HOCOBOII
HOJIOCTH npu gaJIbHCIIHIeM pa3BIITII11 3aXBaTbIBaeT BCe 6OJIbnlyJO
IIOBepXHOCTb, HpIILIeM FI3BbI, yrJiy6JIHHCb, MOrYT Hp1BCCTII N IIpo6o-
j[OH111) HOCOBOII HeperopOAnH. OZ(HOBpCMeHHO IICTCgeHIIe 113 HOCa
CTaHOBHTCH o611JIbHeO, npno6peTar rpr3HO-rHOHHbIH B1Jt OT npH-
MCCH KpoBII. HOAYeJIIOCTHble JIHMC)aTlIneCKHe y3JIbI (maiiie ogHH
113 HHX) OnyxalOT; BHaganie OHH LiyBCTBHTeJIbHII, 3aTCM CTaHOBHTCH
IIJIOTHLIMII, 6yrpICTLIMII, HellOgBII?KHLIMII, Tau nan cpaCTaiOTCH C u0-
neH. 3TH JIIIMC)aTITneCnHe y3JIbI HarHauBaiOTCH OLIeHb peAnO. HpII
He31TagIITeaLHOA BIIpyJICHTHOCTII canHOPO MHnpo6a H AOCTaTOnHOI3
yCTOH'IIIBOCTII opraHH3Ma B03MOMHO 3aHiHBJIeHHe CanHbIX 23B, B pe-
3yJIbTaTe nero HOHBJIHIOTCH 3Be3AilaTble py6ubl, a ecJiII H3BbI 616IJIH
oileHb MaiieHLHHe, OHII OCTaBJIIHOT JIHHIb He60JIbmue 6eJIbie IIHT-
II IIIInH.
C RaJIbHeIIHIHM pa3BIITHeM 601103HH JIOIIIagb XYAeeT II noru6aeT
B TeneHHe 1-3 McCaueB IIpH CHJIbHOM HCTOIIICHIHII.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
K o m H bI H c a ii xapaKTepH3yeTCH IIORBJIeHHeM Ha KOHSe
(Mall a 3a) HHx KoxegHOCTeII, HO Hepe) HO H IIepeAHIIX, Ha rpyAH,
nee, rOJIOBe, MOIHOHHe) y3AOB, KOTOpNe 3aTeM npeBpaluaIOTCH B H3Bbi.
H3BLI AOBOJIbHO r7Iy6oIHe, HMeiOT HepOBHMe Kpaf, canoBHAHoe AHO
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geCISHe cocyAbI, IIpoxoAHume B o611aCTH H3B, yTOJIL IOTCH B BHAe
HIHypoB. IIo xoAy 3TIIx IIIHypOB HepeAKo o6pa3yIOTCH CBeHSHe y3JIM
H H3BEI. B03MOMHO McAnennoe 3aHSHBJIeHHe Has c o6pa3oBaHHeM
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HOCOBbIM; nOIIIaAb IIOrH6aeT IIPH CHnbHOM HCTon. eHHH. IIpH KOHSHOM
cane OTMeLIaeTCH OTegHOCTb KOHeTlHOCTeu, oco6eHHO 3aAHHx, HOTOpble
CHnbHO onyxaioT (CnoHOBOCTb HOr HpH cane); Ha6nIoAaIOTCH Tame
PHc. 108. Canabre B3BLI Ha HOe00OH neperopo;Ixe.
XPOMOTbI HPH OTCyTCTBHH OCO6bIX IIpHLIHH, KOTOPbIMH MOHSHO 6bIJI0 6bI
o6'bnCHHTb HX npOHCXOHSAeHHe.
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pble yua3LIBanH 6bI Ha eanHoe IIOpaHSeHHe. KOBnIIneHHe TeMIIepaTypbI,
nOCTeneHHOe HcxyAaHne nomaJH, 'IacTHgHal IIOTepn eio pa60TOCIIO-
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qHe canHoro npoI ecca, eCJH HeT ApyrHx npwIHH, KOTopble o61ecHHnH
4bu npOHCXOHSAeHHe 3THX HBJIeHHA. 1103TOMy can nernHx ~iacTO AnH-
TenbHOe BpeMH OCTaeTCH HepaCn03HaHHblM, ecnn AnJ ero AHarHOCTHKH
He npH6eraloT H ManneHHy.
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HbIX n3MeHeHHI3, KOTOPbIC He AaIOT AOCTaTOLIHOro OCHOBaHHH npH3HaTb
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It He 6MITb paCII03HaHHbIM. BOA BJIIIHHHeM yCnOBHI3, yxyAmaloigHx
o6iuee COCTOHHHe nonma)H, Haul, HaapHMep, ycnneHHal aHCIInyaTa-
n;HH, nonHHSeHHe nHTaHHH, pyre 6oae3HH, Ocna6nnIOH[He opraHH3M,
B03MOHSHLI o60CTpeHiae cannoro upouecca H IIepexoi xpoHHgecxoi3
( IOPMbI B OCTPyIO C nOHBneHHeM IIpH3HaKOB HOCOBOrO HJIH KOHSHOro
cana.
TIpi xpOHH90CHOM cane npoI;eHT BbI3AOPOBJIeHHH AocTHraeT 30.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HaTOJloroaiiaTOMHTIecHHe H3MeHeHHfl. HpH BCHpbITIIH Jioniage i o6-
pawalOT BHHMaHHe Ha non y, wxaTeJIbHbIH annapaT, JIHM(f aTHLIeCHHe
y3JIbI 11 Apyrne opraHbi. Ha HOHCe, B HOCOBOI3 IOJIOCTH, B ropTaHH
n B Tpaxee MOryT 6bITb yHa3aHHble BbIIHe y3JIbI 11 H3BbI. B Jlernux
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JIH9HHbi - OT IIpOCHHOrO 3epHa go ropoiiirn ,i. HpH 3aCTapOJIOM die-
rOtIHOM cane B Jfernnx nhiOr a o6HapyHCH-
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r BeTa c OTj(eJlbHbIM11 rHOIIHIIHaMH B HHX.
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CTaAnn npogecca, HMelOT pa3JInLIHbIn B11? .
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Ha HOHegHOCTH. Ba1OT rnoiinoe HOCOBOO HCTetleHne, TnnntlhIOe
onyxaHHC nO geJIIOCTHOrO JIHM(aTIIIIeCHOrc
y3Jia, xapaHTepHble AJIH Cana y30JIHn 11 II3BMI B HOCOBOH HOJIOCTH HpH
o6igeM nCXygaH11H x31(11 HOrga Ha3InI1o CanHble H3BLI Ha HOSHe C COOT-
BeTCTByIOII[11M OnyXaHn0M HOjIHOHSHbIX JI1M(aTHtieCHnX COCyj;OB,
CJIOHOBOCTb nor H Hp., Torga eCTb OCHOBaHHe yTBep11d aTb, LITO JIOHIaJ>;b
cannan. HOA03peHne Ha can M05HeT BO3HHHHyTb np11 Ha3lntln11 OT-
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no 3THX 11p113HanOB 603 Cnel[H(JHtIeCHHX CanHbIX H3B Ha CJI1131ICTOH
noca HegoCTaTOtIHO j[JIH npn3HaHHH TIOIHagn cannon.
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OCMOTP HOCOBOH HOJIOCTH. C 3T011 UCJIbIO HpIIMeHfTeTCfI pe(JICKTOp -
3epuaJio, oCBen~aIonnee HOCOByIO HOJIOCTb. IIOJIb3OBaHHe pedJJIOlTOpOM
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B03MOHCHO B COJ1He9HbIH AeHb; npII ATOM HCCJIeAyIoIIjHH CTaHOBHTCH
Tail, LITo6EI JIytIH cOJIHua naAaJIII Ha 3epICaJIo H OTpaHCOHHbIM CBeTOM
OCBeu arIH HOCOByIO IIO7IOCTb. Pa60Ta c pe4JIeHTOpOM IIpH HCCJIeAoBa-
HHH JtomaAeu B HOHIOIIIHe B03MOHfxa IIPH IIPHMOHCHHH IICHyCCTBeHHOro
cBeTa.
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YeCHOH (opMe. IIO3TOMy OAHOPO HJIHHIILIeciloro McTOAa AHarHOCTHHH
JIB HcHOpeHeHHH Cana HeAOCTaTOHHO. Ho IJIHHHLIeCHHH OCMOTp
JIOIIIa1eu Ha can o6H3aTeJIeH, Tail Hail OH IIOMOraeT BbIAeJIHTb BCeX
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
2) JiomaAi, IIMeiomi a negCHbie npH3HaJH Cana H AaImme IIOJIO-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
0tHIIUeHHbIMn OT pearHpylomlIx Ha MaJIJIOHH JIOHIaAen BCJIeACTBHe KOH-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HoBaTO-cepor0 1BeTa, c Me7IKHMI3 6eJIOBaTO-COpLIMII 6JIeCTrnluTMH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B OTZ[eJlbxbIx CJIytIanX, BCJIejcTBHe pacnpocTpaxeHHJJ BocnaJrll-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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3Hga otleHb 3apa3HTCJIbHbI H 6bICTpO paCIIpoeTpaHHIOTCH. McI1igy TOM
K0HTarH03HalI IIJICBPOIIHCBMOHHH KaR 011300TH2 IIpOTCKaeT BHJIO,
BbIJIeJIOHHC IIOBbIX 60JIbHbIX HpOHCXOJZHT C 1iepepbiBaMH B HCCKOJIbI{O
J];HOH. HpHMeHeHHe HOBapecHOJia IIOMoraeT JIH(I(IepeH1 Hal HH: IIpH
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3a60JICBaHHHX - 06bILIHO 6e3pe3yJIbTaTHO. HpH HH(JJIIOaHHO H rpHHHe
He Ha6Juo) aeTCH HOpaHieHHFi J(MxaTeJIbHLIX IIyTeI HJIH OHO BeCbMa
He3HagHTeJlbHO. BMeCTe C TOM IIpH HH( JII03HII;e H B MOHbHIOII CTOHOHH
HpH rpHIIIIO pe3HO Bblpa]I{eH KOH'WIOHHTHBHT: KOH'bIOHKTHBa ICHpHHgH0-
KpaCHOrO B;BeTa, Ha6yxaeT; OTMOLIaeTCH CJIe30TegeHHe, CBeTo60H3Hb,
hero o6bILIHO He 6bIBaeT Hp1I KOHTarHO3HOH HJICBpOHHOBMOHHH. Horj a
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(Ha 2-3-K AeHb).
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'iCH: HpH K0HTarH03H0H HJIeBpOIIHeBMOHIIH OHO 06bILIHO C1I HOe m
pmaBoro IIBeTa; HpH 6pOHXOHHCBMOHHHX, OCJIOHCIIHIOWIIX y1a3aHHbIO
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OT 6pOHXOIIHeBMOHHH H3JIOTexa B CTaTbe 44H(12e1lHHOHHaH 6pOHXOIIHeB-
MOHHH)).
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MOFYT 6LITb JZH44epeHHHp0BaHbI B HpOI[CCCO TeueHHH 3H300THH, KorJ(a
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
naToJIoroaxaTOMH1IeCKOe BcxpLIT14C Tarn1 a HMeeT 3HatieHHe B AII( -
(lepenI IaJIbHOH JuIarHOCTHHe. HpH HOHTarII03HOH IIJIOBpOHHeBMOHHH
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HHR 6e3 ogarOB HOnpo3a B JlernHX. MMIT Ha cenl(HH xapanTepH3yeTCH
HaJIHLIHeM (OKyCHOH HJIII pa3JIHTOH rHOHHOH 6pOHXOIIHeBMOHHII CO
CIJIOHHOCTbIO K pa3BHT14IO coej;HHHTeJIbHOH THaHH.
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notion H xopomiHx rHrHeHHilecHHx yCJIOBHI3 cogepmaHHSI. JIyiIIIIHM
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IIJIeBponHeBMOHHH 3HwIHTeJIbHO CHHmaeT HpOI;eHT JIeTaJIbHOCTH H
IIOCJIeAYIOII;HX oCJIO}nHeHHI3. Ao3a Hosapeexojia OT 3,0 go 4,5 r,
B 3aBIICHMOCTH OT Beca JIomaj;H; HR beIAHpyIOT erO TOJILHO BHyTpHBeHHO,
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OTeHOB.
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CBe}ieI3 HHHHtIeHOli BOgbI. YHOTpe6JIHIOT TOJIBHO CBe71H13 pacTBOp.
BJiHBaHHe Hp0H3BOj;HT anHapaTOM Bo6pOBa HJIH 100-rpaMMOBhIM
IHHpHgeM Hpu c06JIIOgeHHH o6II(Hx ycJIOBHl BHyTPKBeHHLIX HH'be]KAHI3
(BbicTpHraHHe BOJIOC Ha MCCTe BBeAeHHR, j;e3IIH()eII;IIn.ero, CTepHJib-
HOCTb HHCTpyMeHTa). ECJIH HpeiiapaT CJIyiauHO nonaj;aeT HOj[ HOMY,
Hy)nHO HeMeAJIeHHO (BO 1436enfaHHe OTeHOB) BBeCTH 100 MJI ()H3HOJIO-
rHiiecioro paCTBOpa xJIOpHCToro HaTpHfl B OKpy?HHOCTH MecTa HH'beH-
I;IIH HoBapcexoJia. HOBapcexoJE HCJib3H Ha3HaLI Tb JIoinagIIM c oCJIa6-
JIeHHOfi cepj(eTixol3 j;eHTeJIbHOCTbIO. I Iepejr ero BBej[eHHeM peHOMeH-
AyOTCH IIpHMeHHTb JieiapcTBexxble BenxecTBa, H0j{HHMaiomHe AeHTeJIb-
HOCTb cepj;iia (HaM(apxoe MaCJio 30 r HJIH Ho(eHH 5 r nogno nHo),
a IIOCJie BBej[eHHa Hpoj>;OJUKaIOT CJIegHTb 3a cepgiwwM H B cJiyLIae HagO6-
HOCTH IIOBTOpRIOT HHieluu4Jo cepjletiHbix cpegCTB.
B HepBbie *Iacbi uoc ie IIH'beRgHH HOBapeeHOJIa Y 6OJIbHOH JiomagH
IIoAHHMaeTCR TeMHepaTypa Teiia II HecHOJlbHO yxyj[maeTCR o6ll ee
cocTORHHe; 3TH RBJIeHHR AOBOJibHO 6bICTpO HpOX0) aT. Jleue6Hoe
peHcTBHe cHa3bIBaeTCR B CHIIHieHHH TeMnepaTypbl go HopMbl B TeileHHe
2-3 j(HeI3 11 B yjiyLIIIIeHHH o611Aero COCTOHHHR 6OJIhHOrO ,nHsOTHoro;
OJHaHO HonBHBIIIerocs IIpOI CCa B JIerHHx H B IIJIeBpe OH He oCTaHaB-
JIHBaeT. HOBapeeHOJI CJIej;yeT pOKOMexgoBaTb B caMOM HaLIasie 6oJIe3HH,
TaH Han IIo3AHee OH He jjaeT 344eKTa. OAHOBpeMeaao C JIegeHHeM
HoBapceHOJIOM HCIIOJIb3yIOT H j[pyrHe JIetIe6Hble Cpej[CTBa: ropgH4-
HHHH, cJIa6HTeJIbxoe, cepAeLIHble. HpH HOBOM IIogbeMe TeMHepaTypbl
MOMHO HOBTOpHO BBeCTH HOBapeeHOJ, no He paHbmie ileM LIepe3 3-
4 j[HR IIOCJIe IIepBOH HH'beHI;HH.
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JiII'IeCTBe 2-3 MJI).
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Mi eogep naHHR H HOpMJIeHHR H aHHI1 IIOCTeIIeHHO BTHrHBaIOT B pa60Ty.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Mepbr npoq)HnaxTllHH H 6opb6br. MeponprcITHH Ho 6opb6e c noH-
Tar1103HOH IIJIeBpOlIHOBMOHHeH JIomagef B OCHOBHOM CBOAHTCH E CJIe-
J(yIowCMy. 06ii ue Hpo(HJIanTHtICCI{HC MepbI: a) co6JiiogeHne rirrHC-
HHpleCnHX yCnOBHH cogep?naHHH nomaJJef (J~JIHTCJIhIIOe eoj[CpNiaHHe
Ha CBOH eM B03AYXC H HaCTOe HpOBeTpHBaHHe HOHIOIHHH); 6) I1paBYIJIb-
HOe nOpMneHHO; B) CTpOrOe perynIHpoBaHHe pa60TbI (603 nepCyTOM-
JIeHHH Jnomagei); r) napaHTnHHpOBaHHC Ha 20 j[HCri BCCX BHOBL
HOCTyHaIO1I HX B XO3HHCTBO nouIaj(eH.
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jSeH HeMeJ;neHHO HO,qBepraIOT BeTepHHapHOMy OCMOTpy H TCpMOMeTpIIH.
Ha OCHOBaHHH peayJlbTaTOB HCCJICROBaHHH JnomaJJeu pa3J[CJIHIOT Ha
3 rpynnbI: 1) HBHO 60JIbHJIX, 2) IIO,I{O3pHTCJIbHhIX HO 3a6OJICBaHHI0,
3) HOA03peBaeMbIX B 3apax{eHHH. HMO 60JIbHbIX JIOHIaAeH (1-H rpyH-
na), a TaI*rfe llO,I;03pHTeJIbHbIX HO 3a6OJIeBaHHIo (2-H rpyrina) HeMeJ;-
JIOHHO H30JIHPYIOT nan OT OCTaJIbHbIX JIOHIaJ[CH, HOA03peBaeMbIX B 3apa-
?neHH11 (3-H rpyHIia), Tan H J{pyr OT JJpyra. ,T.IJIH HOAO3plTeJIbHLIX HO
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HpeAMeTM yxo a H cHaprN{eHHH H3OJIHpOBaHHMX ?HHBOTHbIX yAaafHOT
O,qHOBpeMeHHO H ge3HHI rnI HpyIOT. CTaHON, OTnyga BbIj[eneHa norlagb,
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TH[aTOJIbHO ogHI4aIOT McXaHHgedI{H. HaBo3 J( O3HHIJH4HPYJOT CBC?ne-
raHIeHOH H3BOCTbIO HJIH 6110TepMWICCllM MCTOJAOM (2 MCCHr(a).
Ha He6JIarorio iygHyio LIacTb XO3HHCTBa HannraAbIBaIOT napaHTHH
C BBeAeHHeM CneJJyIou ux orpaHHLIHTeJIbnbIX Mep: a) BocnpeIriaeTCH
BCHHOC nepeMen[eHHe JIomageI3 BHyTpH XO3HHCTBa (win LIacTH ero),
a TalH{e BHyTpH noHIOHIHH; 6) He6narononlynHaH noHlomHH cTporO
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H B 3T0 BpCMH yCHJIeHHO ROpMHT. HocJre npe6bHBaHHH B rpyuIIle BbI3AO-
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cnorO MeponpHHTHH (B r(eJInx npenpau(errua 3H300T1,111) C ycnexoM
HpHMeHHJIH IiOBapceHOJI B go3e 2,0-3,0 (npo~lJranTHLICCI{aH HOBap-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ceHOJIH3aT HfI). HeHpeMeHHbIM yCJIOBneM IIpH 3TOM RBJIHOTCq BBeRe-
HHe IIperapaTa BCeM JIOIIIaARM He6JIarOIIOJIyiIHOn HOHIOIIIHH 110 B03-
MOH{HOCTH B TeLIeHI10 OJ{HOrO J;HR. OJ(HOBpeMeHHO neo6xo IMa J;e3nH-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
060JIOLIKOii gblxaTenlLHoro annapaTa. rlpH HoJIOHfHTe7lbxoM pe3y7lbTaTe
3apameHHH uepBbIMH KJIHHHLIeCIHMH HpH3HaEaMH ona3blBaIOTCH CepO3-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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HOBble 6oJIbHLIe Bblj;eUIrIOTCn C IIepepLIBOM B HeCHOJIbIO AHe1; BO BpeMn
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
COBep1IICH110 OI TI3aTCTIbHbI HCMICAJIelllIOC OCBO601K90111Ie 3a6oJICB-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B If0?Ke 11 110AK07KHO11 COOJ(HHHTOJIhIIOH TKaH11. VBCJI11gH$a2Cb, 01111
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIIH300TIILIECKIM OIII);E bA.'IOMIIEJIILT JIOIIIAJEf
(Enzephalomyelitis equorum)
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
AJIH HeHOTOpLIX HCCJICAOBaTCJIeI3 ocHOBaHHeM yTBep}E aTb, 'ITO 3HT,e-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JJHCH, rOBOpIIT B HOJlb3y Toro, 9TO HpOBOCOCyH[He iITIeIIIICTOHOrHO
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HPHBHBHH TOJILHO B TOM CJiylIae j(aIOT n006XOAHMbII3 a4 erT, HorAa
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(Coryza gangraenosa bovum)
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60n3Hb (rJiaaa o6wiHO 3aHpblTbl). B p;aJlbHeI3meM JJa3I3HBaCTCn IIOMyT-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HeHHe porOBHi t, a HHorAa oHa H3'bf13BJIleTCH. B HeROTOpLIX cJIytlafX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B HogeTIHblx tiaHrHax. CeJIe3eHIta 6oJILHIeii 'IacTbTO HopMaJIbHa, HHorAa
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(Pestis bovum)
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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470
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I OHtn c y6HTmIx a nantnHx 6oJILHbix Ho3 cynlaT na Bo3Ayxe it
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491
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIyrax, a TaKaCe B c13A311 C HcuoJl1,3oaaIHeM JXJIFI BOJt0HOH CTOHtHIX BOAO-
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BaHunxy FOTOBHT 143 OTO6paHHblx 1HTaMMOB Vibrion septique Ha
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opMaJInHOM. DOpMOJIBa1Il1Ha IIpOTHB 6paT3OTa OBCA HMCCT BH3KyIo
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HpenapaT o6pa3yeT Ha J[HC 4 JIaKoHa oCaJ[oK M1Kpo6HbIX TeJI, KOTOpbII3
nepeg HpiMeHeHueM BaHAIIHJA HepeBOZI,HT BO B3Be1IeHHOO COCTOHHHe
BCTPHXHBaHHCM.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HpIIBHBHaMII oxBaTmIBaIOT Bee norOJTOBbe OBeq c 3-4-MecngHOrO
Bo3paCTa. BaHi[IIHy BBOAHT BHYTpHMMUlelgHO B o6JIaCTH 6eApa ABy-
HpaTHO, C HHTepBaJIOM B 14-18 AHeii. Y MHOPIIX OBer[ IIOCJIe IIPHBIIBOH
Ha6JIIogaeTCFI XpOMOTa B TeileHHe 1-2 CYTOH. HMMyHIITeT HaCTynaeT
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CtiueB.
HapiAy C npiIBHBHaMH Heo6xoAHMo OCYiu CTBJIFITb cooTBeTCTByIO-
JJAHI3 HOMHJIeHC BeTepnxapHo-caHHTapHbIx MeponpHHTHI3, o6pawaiI
oco6oe BHIIMaHJ1O Ha npaBHabnoe HopMJIeHIIe OBeg IIpi Hx nepexoAe
OT CTOI3JIOBOrO CoAep}HaHHFI H nacT6Hn[HOMy. B 3TOT nepnoA peHoMeH-
AyeTCFI He BbIPOHHTb SHUBOTHbIX Ha IIaCT6Hme paHO yTpOM, H36eraTb
npH 3TOM 3a6OJIOLICHHNX McCT; BHJIIOLIaTb B pai iiou rpy6ble HopMa
(ceHo), yCIIJIHB MOJI IOH BO BpeMH naCTb6bI.
BoJIbHbIX H3oJIHpyIOT; TpynbI IIaBIIIHX CBOCBpeMeHHO H HaAJIe1Ha-
WITM o6pa3oM y6HpaIOT; He6JIaroUOJIyLIHble uaCT6III(a u BOAonO$
GMOH FIIOT.
HH-MEI#AIIOHHASI OHTEPOTOI#CEMI3fT OBEA (PA3M,fIr4EHHAa HOTII#A)
(Enterotoxaemia infectiosa ovium)
OnpegeaeHHe 6oJIe3Hn. HH(IeHIUHOHHaH 3HTepOTOHCeMHFI OBeq --
OCTpO npOTeHaIoi1 ee HeHOHTar$o3HOe 3a60JIeBaHHe. Ho HMeionjIMcn
AaHHIIM, 60JIe3Hb }IBJIFIeTCH pe3yJl16TaTOM HHTOHCHHaI[HII opraHH3Ma
6aHTepIHTH16IMn HAaMH MIIHp06OB rpynnbl B. perfringens, 6ypHO pa3-
MHOHfaIoiiAHxCH B HHIIIeLIHIIHe. 3a6oJIeBaHHe Ha6JHOAaeTCH BO MHOrHx
cTpanax H perlCTpnpyeTCH TaH]He B CCCP.
B036y9IITeJIb 6OJIe3HH H 4)aHTOpbI, COAeIICTByIOwHe ee npoJIBae-
HHIO. B nocJIeAHHe rOAhI OHOHLIaTeJIbHO yCTaHOBJIeHO, iITO B036yAH-
TCJIeM HH()eHI;HOHHOH 3HTepOTOHCOMHH OBeu CJiy}HaT MHHpo6bI H3
rpyriri B. perfringens Tuna C Hail D. CBeiHeBiIAeJIeHHble HyJIbTypbI
3TIIX THIIOB B He60JIbIIIHX Ao3ax y6IIBaIOT MOpCHYIO CBHHHy BecOM
B 300-500 r Menee 'qeM B CYTHH. 3TOT anaapo6HbiI3 MHHp06 o6pa3yeT
B opraHH3Me 1HIBOTHOro HancyJlbl, a BHe opraHH3Ma enoco6eH H cnopo-
o6pa3oBaHrIO; y OTACJIbHMX IHTaMMOB CHOphI ogeHI, CTOuine IT BbI-
Aep}HHBaIOT 8-90-MHHyTHoe HHnHLIenue.
B. perfringens LIaCTO BcTpe*IaeTCH B nOHBe H OTTyAa noua)aeT
B HHnIeTIHIIH HCHBOTHOro, HBJIUFICb 06m HMIM ero o6HTaTeJIeM. OAHaHo
HeHOTOpble MOMeHThI 6JIaronplaTCTByIOT 6ypHOMy pa3BHTHIO B. per-
fringens B HHHie*IHHHe, ToHCIIHoo6pa3oBaHro, BcaCMIBaHHIO TOHCHHOB
H OTpaBJIeHHIo opraHH3Ma. H TaHIIM MOMeHTaM OTHOCnT: BFIJIOCTb II MeA-
JIeHHyIO IIepuelfaJIbTHHY HuuIe'IHIIHa, *ITO M0)H T o6yCJIOBHTbCH OT-
CYTCTBneM MorJuoHa; o6IIJIbHOe IT HepaI;TOHaJIbHOO HopMJIeHHe, HOTO-
poe HaCTO HapyiuaeT Y SHHBOTHLIX MOTOpHEIe II ceHpeTopnbie 4IyHHI;HH
HHIIIetIHHHa, a B CBFI3II C 3THM H3MeHFII0TCFI (JIOpa H peaiiuuu ero
co epxcuMoro. TpaBMaTII3aiJIIa 1HeJIyAO'IHO-HIIIIIe'HOFO TpaHTa TaHHfe
MOHfeT co euCTBOBaTb npOFIBJIeHHIo 6orIe3HH.
ffJIHHHiieCHHe upu3HaHu. Ha160Jiee gaCTO BCTpeiiaeTCH MOJIHIIeHOC-
#iax c iopMa 3HTepOTOHCeMIIH, oxaH*IHBaIon;aHCBI OLICHb 6bICTpO CMepTbIO.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B OTAOJILIMIX cJlynaHX y 3a6OJIeBIIIHX yAaeTCH Ha6JnoAaTb CHMIITOMbI
KOJIHK, IuaTKOCTb IIOXOAKH, ycHopeHHe AbIXaHnn, HHOrj[a CJIIOHOTO-
HeHHe, CHpeHCeT 3y60B; *lepe3 He1OTOpoe BPOMH H IBOTHOe naAaeT H
6MCTpo I146HeT B cy)oporax. HpH OCTf OH 4)OpMe 3HTepOToEceMHH
oTMetiaeTCH IIOHOC, LIacTO c AypHO naxnynurMH (Je1aJIHHMH, K HOTO-
pblM npHMeIIInBaIOTCH HpOBI, H CJI113b. HHBOTHOC TeJHeT anieTHT,
xyAeeT; Co3HaHHe Y HerO 3aTeMHeno; LIaCTO HaCTynaeT EoMaT03HOO
cOCTOHHIIe. BoJIe3Hb npogoJIHCaeTCH 1-3 cyTOH, HOCJie nerO OBua
IIorH6aeT. I4HorAa y B3pOCJlbIxoBeu6oJIe3HbnecxoJlbxo 3aTHrnBaeTCH
II xapaHTepH3yeTCH ReJITyHIHOCTLIO CJIH31ICTLIX o6oJIOgeH, aHCMHeii,
HHOrAa B036yxcAeHneM HJIH pC3KOH AeHpeCCHeH. IIpH Ta1OM TCLIeHHH
B03MO1KHO BbI3AOpOBHeHHe, HO H 11BOTHble OCTaIOTCH HCHOJIHOIJeHHbIMH.
HaTOJIoroaHaTOMngeCKHe H3MeHeHHn Bbipaw alOTCH B 6bICTpOM
pa3JIOHfeHHn TpyIIa, HaJIHYHu TeMHbIX HJIH (IHOJIOTOBNIX IIHTeH Ha HOMO,
KpOBOH3JIHHHHHX B CJIH3$CTOH o60JIOtJKe TOHICOro KHIIIeLIHHKa, rHHe-
peMHI3, COMHOCTH H yBeJIH'IeHHH Me3eHTepHaJIbHbIX JIHM(aTHLIeCHHX
y3JIOB. KpOBOH3JIHHHUH Ha6JIIOAaIOTCH HOA 3HAO- H 3HHKapAOM,
B pe3KO Hepepo}H eHHoi4 neueHH a Apyrnx opranax. HomKn - oAHa
HJIH o6e - Hpe)jcTaB,nHIOT Halunueo6pa3Hy1o KpoBHHHCTyIO Maccy
(OTKyAa 14 II OI430HIJIO Ha3Banne ((pa3MHrtIOHHaa noLIKa)). CeJIe3eHHa
He yBeJIIIMeHa.
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II HaTojloroanaTOMHYeCKHx AaHHbIX. BoJIbIHoe 3HaMellne 1MOOT 6aK-
TepnoJIorii ecioe nccHeAOBaHHe, Aaioa[ee B03MOHdHOCTb HCHJIIOMIITI
CXOAHbie C 3IITepoToHceMHeIi 6oJIe3HH. B Jla6opaTOpulo HanpaBJIHIOT
coj{ep}H1MOe KHIIegHHHa, napeHxHMaT03HbiO OpraHbl, 3I{cyAaT 113
6pI0IUHOi3 IIOJIOCTH. B 3THX MaTepuaJlax o6bIIHO HaXOAHT 6oJIbuioe
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COBeTCKHMH HccJIegOBaTeJIHMn (M. L. TIOJIbIKOBCKUI3 H F. A. Ko3-
JIOBCKHYI) pa3pa6oTaH MOTOR AH((epeHqua1HH TIIHOB B. perfringens
upH IIOMOH[H peaKunn HoJlbuenper 11ni3Ta1Hn. ,Lim ee noCTaHOBKH
B cepoJiorH*iecKHx npo611pHax Ha cnewf(J)wiecRUe npewHU1THpylo1JIIe
CbIBOpOTKH HacJIaHBaeTCH aHTHreH, npnrOTOBJIeHHbII3 113 nccJIeAyeMblx
HyJlbTyp. HOHBJIeHHe npeunn1TagHOHHOrO KoJIb1[a Ha rpaHUue coupH-
HOCHOBeHHH auTHreHa c OAHOH H3 THIIOBbIX CbIBOpOTOK AH#epeHIIH-
pyeT THII Bo36y)HTeJIH.
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AHMO IICKJIIOLIIITb CH6npcuy1O H3By, HHpOIIJIa3MO3, 6paT30T.
JTeeeHHe, Hpo()nJIaRTmKa n Mepbl 6opb6bl. BB1Ay OCTpOTbI TeMe-
HIIH 9HTepOTOXCeMHH JIeLIeHUe 06bILIHO 6bIBaeT 6e3pe3yJlbTaTHbIM.
06pai4aioT oco6oe BHIIMaHne Ha Te H3 np04)HJIaHTHLIeCHHx MeponpHH-
TI-HI, KOTOpMIO coAeI3cTByloT ycIJIeHHIo neplCTaJIbTI HH KHHIeMHHHa,
yMnTbIBaa, 'ITO 3aMeAJlennbie ere ABH7KeHHH 6JlaronpHHTCTByIOT pa3-
MHOH{eHHIO BO36yAHTeJIH 60JIe3HH. B 3Tnx ueJIHX MOx{HO peKOMeHAo-
BaTb ycHJieHHe MowlOHa, Aagy rpy6blx KOpMOB (Celia, coJIOMM),
YaCTyIO CMCHy naCT61mj.
B He6JlaronoJly'IHblx X03HICTBax IIPOI13BOART npeAOXpaHHTeJIb-
Hble npHBHBKH BceMy IIOrOJIOBbIO OBeIJ B HocJIeAHHe Mecaubl CT09JI0-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BOrO coAepHIiaHITH 6HBaJIeHT11OI3 ( opMo7IHBacgoBOI3 BaHIjHHo}I IIpoTHB
3HTepOTOHCeMHH n 6paT30Ta OBerj, npeJjJIOHSeHHOII A. B. .IIHyIIIKIIHbIM.
BbIHy?Ic eHHble IIpHBHBHII BO3M0?HHbI B JIIo6oe BpeMH. HMMyHHTOT
HaCTyuaeT =Iepe3 jLBe HeJieJTH nociie IIpHBHBOK H npo);OJnKaeTCH AO
HIeCTH MecfljeB. BaHIjHHaIjHH AByxpaTHaf, C IIHTepBanoM B 16-20
j[HeH. rTjO3LI npH iJ BOI3 H BTOpOH npHBHBHax COCTaBJIHIOT 5 MJI.
BaIIjnny IIH'beI HpyIOT IIOJj HOMY B o6JIaCTH nepegHOii HOHegHOCTII.
Y HeHOTOpblx OBeII MO?ICeT Ha6JIIoAaTbcH peaHljnH Ha IIpHBIIBKH:
XpOMOTa Ha nepeJjHIOIO KonetinocTb, noJ;'beM TeMnepaTypbl Tena Ha
0,5-1,0?; 3TH CHMIITOMbI HCLIe3alOT ilepe3 3-4 ) HH. Ony6JIHKOBaHHble
MaTepHaJlbi yHa3hIBaIOT Ha 60JIbHIyIO a((eKTIIBHOCTb TaHOII BaHIjII-
HarHH.
HH4)ERIIHOHHASI APAJIAIfTHR U03 H OBEII;
(Agalactia infectiosa)
OnpejjeJleHne 6oJIe3Hn. I4H~eKgHoHHaH araJiaHTIH H03 H oBeIL -
BecbMa 3apa3IITeJIbHOe 3a6oJIeBaHHe, xapaHTepH3ylOII;eecH nopaHCe-
HIIeM BbIMeHH; OHO COIIPOBOHKgaeTCH pe3HHM yMeHbfIeHHeM HJIH IIoJI-
HIIM HpeHpai eHneM CeHpeAHH MOJ oHa; BO MHOrHX cay'Iaax aa6oJie-
BaHne oCJIO?KHHeTCH apTpHTaMl H HepaTHTaMH.
PaenpoCTpaueHHOCTb 6OJIeaun a ee axonoMwJecl oe 3HaveHne.
11H(JeKIjHOHHa} araJIaHTHH BnepBble onncaHa B 1816 r. B I4TarInII,
a B JjaJIbHe13IIIeM ee CTaJIW perncTpnpOBaTb BO MHOrHx CTpaHax (Ha lore
DpaHljnn, B I11BeHijapHn, PyMbIHHH, BoJlrapHn, IOrocJIaBHH H AP.).
B CCCP 3T0 3a6oJIeBaHHe, IIO-BHJjHMOMy, CyiueCTBOBaJIO JjaBHo, Ho
Jjngic epeHI HpOBallo ono 6bIJI0 B 1936' r. B A3ep6aHJj naHcROI CCP,
B 1943 r. B ApMeHHH, B 1944 r. B Ppy3nH.
1IH()eKI[n0HHan araJIanTHH npHTiHHHeT xO3HI3cTBaM, rJje oHa
nOHBJIHeTCH, JjOBOJIbHO cepbe3HbII3 alloHoMHLIecHHR ynjep6. B He6JIa-
rolIOJIytIHblx oTapax nopaHfaeTCH OT 15 go 50% norOJIOBbg, B CBH3H
C qeM TepneTCH MHOro MOJIona (yJjon y noJjaBJIHloujero gHCJia nepe-
6oJieBIIinx OBeIj BOCCTaHaBJIHBaIOT JIHIIIb iiaCTHRHO H cJIeAylouxeMy
roJ[y). OIIjyTnTeJIbxbI H UOTepH OT BBI3BaHHmIx araiianTHen BbIHH-
Jjbimeii H rH6eJIH HrHHT (Jjo 15-20%), a TaH?Ke B pe3yJlbTaTe HCTO-
IljennH IIepe6OJleBaloltjTX H JieTaJlbHOCTH cpeJjH HIIX, CoCTaBJIHlonjeH
OT 2,5 go 30%.
B036yJjHTeJIb 60Jle3HH Capromyces agalactiae, BBHJjy 6JIH30CTH
Mop(JOJIOrH'qecHnx II HyJIbTypaJlbHbIx CBOI3cTB ero H Boa6yJjHTeJIH nepn-
nneBMOnnn KpylHOro poraTOrO CHOTa, OTHeceH H rpynne TaK Ha3bI-
BaeMbIX nepHHHeBMOHrITHblx MHxpo6OB.
Bo36y)jHTeJIb araJlaRTIH cloco6eH IIpOXOJAHTb ilepea MHorHe
6anTepHuiHbie 4)HJIbTpbl; ero MO?HHO HyJIbTHBnpoBaTb Ha HCHyCCTBeH-
HhIX IHTaTeJlbnmIx cpeJjax H BIJjeTb HPH yBeJITTIeHHn 06LILIHOro MHxpo-
cxona.
IIpi paCCMOTpeHnH IIO) MHxpocnonoM Ma3nOB Ha naTOJIorH*ieCHoro
MaTepHaJla H H3 HyJI16TyP yCTaHaBJIHBaIOT IIOJIHMOp(JH3M MHHpo6a:
OH npeJjcTaBJIHeTCH B BHJje TOHHHX naJIolqeH, HOKKOBhi HbiX H KOJIb-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I[eBHAHbIx c OpM, HeOnpeJeJIeHHbIX 3epnlCTbIX o6pa3OBaHnII. iTy'imo
OKpaIITIIBaIOTCH Ma3HH no POMaHOBCHOMy - FHM3a.
B036YAUTOJIL araJlal{Tir HYJIbTHBHpyeTCH Ha MapTeiOBCHOM 6yJIb-
OHe c Ao6aBJIeHHeM CLIBOpoTHn OT JIOIIIaAeii, OBeI[, I{03 HJIH HpylHOrO
poraTOro cHOTa. POCT nonBJlaeTCJ Ha 4-7-1i Ae1b; no xapa1Tepy
poCTa OH HanoMHHaeT HyJlbTypLI IlepnnxeBMoHHIiHoro MHHpo6a
(C TPYAOM BbM1BJIIIeMOe IIOMyTHeHHe 6yJIbOHa IIp1 cpaBHeHHH C LIHCTOl3
cpeAoli).
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pII3yeTCa CJIeAyIOII[HMH AaHHbIMH: OH TepMOJIa6HJIOH H rn6HOT npH
TeMnepaType 50? Llepe3 I 1/2 Baca, npn 60? - LIepe3 5 MHHyT. B 3anaHH-
Hblx IIHIIeTHax HpH 37? MHHp06 COXpaHaeT 1HII3HOCHOCO6HOCTb go
22 McCHIZeB, a BHpyJIeHTHOCTb - AO 15 McCHI[eB. HaAe1HHMMII Ae-
311HIPHI[IIpylOMIIMH CpeACTBaMH lIBJIHIOTCH 20-npOL[0HTHbIH paCTBOp
CBO?HeramcHOTi n3BOCTH, 2-HpoL eHTHbIH paCTBOp JIH30JTa, 1-2-ITpo-
I[eHTHbIII paCTBOp eAHoro HaTpa HJIH imam.
3Hn30oTOJIornwemie j(aHHLle. H HHI eHI[noHHOII araJIaHTHH BOC-
npHHMgllBbI H03bI H B HeCHOJIbHO McHbiuei CTeneHH O11]1 i,I; 0006CHHO
'IyBCTBHTOJlbnbI H Hen JIaHTHpyIOII[ne KHBOTHble; H03JIHTa H 1I'HHTa
6OJIOIOT peace. HCHyCCTBeHHOe 3apalneHHe B03M0}HHO BBOAOHHOM Ma-
TepnaJia, CoAepman[ero BO36yAHTeJlH, IIOAHOIHHO, BHyTpHMbIHIegHO,
BHyTPIBeHHO, LIepe3 pOT, B COCHOBI,III HaHaJI, TpaxeIO, HOHbIOHHTHBy.
B CCTOCTBeHHbIX yCJIOBHHX HCTOiiHHHOM HHI eIH HH HBJIHIOTCH
60JIbHble if nepe60JIeBMIIe 1HIIBOTnbie, BbIAeJI1H011 ne B036YA11TOJIH
B TegeHHe AJIHTOJIbHOrO BpeMeHH C MOJIOKOM, MOgOH, H3JIOM H HOH'bIOHH-
TIIBaJIbHOii CJI143blO. CCpbe3Hyl0 pOJTb B paCHpOCTpaHCHHH HH(oHI[HII
HrpaloT JIIOAH, HOTOpile MOrYT nepenocHTb Ha CBOOM HJIaTbe H o6yBH
1H(1HI[HpoBannbMI3 MaTepna.i game B Apyrne xo3JII3cTBa. ,11,oeHHe
1HHBOTHbIx-BHpyCOHOCHTOJIej B 3Ha'IHTeJIbHOH CTeHOHH COAeiCTByeT
nepeAage IIH(f eKI rHi H 6hICTpOMy pacllpoCTpaHeHHIo 6oJ1e3HH.
HHC eHI[noHHaa araJIalTIM Ha6JlloJaeTC1 06bItIHO B ropncTblx
MCCTHOCTHX HpH IleperoHe 1H14BOTHLIX Ha JIeTHHe ropnble nacT6HH[a.
YCTaHOBJIOHO, LITO 3a6oJleBaHHe 06bigHo nOiIBJIHeTCII B nepuOA OHOTa
E03 H OBeI[.
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cJlyiIan ee perIICTpHpyIOTCFI B anpeJie II Mae; o1n HoJn3tIeCTBeHHO
HapacTaloT - B HIOno-aBrycTo, a 3aTeM Ha6Jno aeTCH CHH?HeHne 3a-
6o.leBaeM0CTH.
CTaI[HOnapxoCTb 3a6OJIeBaHHFI B X03HiiCTBax o6bHCHHeTCH AJIH-
TeJIbnOCTbIO BHPYCOHOCIITOJIbCTBa uepe60JIeBIHHMH 1HHBOTHbIMH; HO
OTAeJIbnbJM Coo6WOHJfJTM, BbIAeJIeHHe B036yAHTeJIa araJIaKTHH C MOJIO-
HOM H MOLIO$ MO1HeT HpoAoJIIHaTbcH AO CeMH MOCHI[eB.
KJIHHHgecKHe Hp113HaKH H Te` emie 60JIe3HH. B 3aBIICHMOCTH OT
yCJIOBHIi, B HOTOpbIx IIOaBJUieTCH II npoTeKaeT 3a6oJIeBaHHe, HHHy-
6aI[nOHHbIIi nePHOA AJIHTCH OT 5 go 60 AHeii. HJIHHHgecHHe npn3HaRn
araJla}THH BecbMa MHOroo6pa3Hbl. BHagaae OTMegaeTCc HOAbeM
TeMIIepaTypbl go 40,5-41,5?, HOTOpaa yAeplHHBaeTCH Ha 3TOM ypoBHe
3-5 AHeI3, a 3aTeM TIacTO cHHHfaeTCa AO HOPMbI H BHOBb AaeT B3JIeTbI.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ZHBOTHOO yrneTeno. nocrenel3HO HOHBJIrIOTC%l npn3tlaltl noparteHHH
BbIMeHH, rJIa3 H CyCTaBOB, LITO AaJIO ocHOBanne paccMaTpHBaTb ara-
JIaI{THIO Kart npOJ eCC, npoTexaIOn;nI3 B TpeX ()opMax: MaCTHTHOII,
CyCTaBHOI4 H rJIa3HOI3.
Ha16ojiee LIaCTO y 6orlbnblx nopa?KaeTCH BbIMH, H `IeMy BIIOCJIeg-
CTBHH nplcoegHHHIOTCH BOCnaJInTeJIbHble HBJICHHH CO CTOpOIIM Cy-
l o p m a 6oJIe3HH o6bILIHO HaiIHHaeTCH
C yMenbnleHHH CerpeIAHH MoJIolta, KoTOpoe CTaHOBHTCH ryCTbMM
H COJIeHbIM Ha BHyC, a BnoCJIeACTBHn H3 BbIMeHH BhIAeJIHeTCJI JIHIIIb
BoJI,HHHCTas ?H1V ROCTb co crycTxaMH. IIpH OCJIO}KHeHHH rnoepoAHOi3
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(oJ;Ha HJIH o6e ero AOJIH) yBeJIHiIHBaeTCH B 06'beMe, CTaHOBHTCH
M a C T H T H a H
PHC. 139. rJIa3Haf c opMa HH(emmoi HO14 arana}THH:
JlapexxHMaTO3HbIIi KepaTHT JIeBOrO rJla3a.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HCTOll enIre, HapeaLI; B 3TIIX yCJIOBIiflX 1303MO rra rn6eai, 60Jn,uoro
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BOJIbHbIX AcacCOo6pa3Ho coJepICaTL B 3aTCMHeIIHOM HOMeII[OHHH.
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 i
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HpH MacTHTax HpHMexflloT BOAHbIH paCTBOP HoAa H HOAHCTOrO
xaJHHH (HOAa HplCTa.HJIH*HecHOrO 0,1, fIOAHCTOro xaJlHH 0,2, BOAM
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
613Ir[e B TOW11110 8 MCCHI[eB. H MBOTIIbIx, He 11 OA9a1oll[Hxcfl JICTIOHHh),
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Ha HpeAMeTHOe CTeHJio HOMeiRaIOT HaIIJIIO aHTH1'eHa (n HOTOpOH Ao6aB.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JICI1 JIHMOHHOISHCJIbIH IIaTp) 11 CBe1I1yIo KaiJuo ueJIbIIOII KPOBH H3 60-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIpH nOnBJIeHHH 6auHJi.unpIIoro 6erioro nOHOCa x03BIICTBO O6tiHB-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
AIIH ITOCTS'HJICHIIH IIX 13 Xo3HLICTBO 113 1Il1BV61TOI)110-ITTHIICBOJ);YCCBI1X
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B 3apb"TbIX B 30MJIIO I{ypIIHbIX TpynaX BYlpyc lOr146aJ1 npII TeMIIC-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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525
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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B He6JlaronoiTytTlbIx Ho tiyMe XO3ITIICTBax, nocne yHH1ITOHC0H1H
BCel3 60JIbH011 H noAo3p1TeJlbnoiI no 3a60JIOBaHHIo tIyMOII IITHIjbI, BCe
OCTaJIbHOO IOTOJIOBbO, AOCT1irllee 25-AHOBHOr0 B03paCTa, npIBIBaOTCI
H B TetleHHe 15 AHOII cOAepnCHTCFI H3oJIHpoBanno. CpeAH 3TOII IITHIjhI
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Y HeHOTOpblx 1T14IB Ha 3-8-Ii Aenb nocne BaHIjHIIaIjHI3 MWROT BO3-
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CHHHCeIinfl flllljeliOCKOCTH, nape3a HOHetiHOCTeA, HHOrAa noHOCa.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IIH4bEhI1;II0HHbIU TIAPIIHI0TPAXFHT U P
(Laryngitis infectiosa gallinarum)
OHpeAeJleHHe VOJIC3JHI. BII(1CHI[11OIIHbI11 JIapill n'OTpaxCYIT HpeACTaB-
JIHCT co6oui Ho HpenMyiuecTBy OCTPoe 3a6oneBalte, xapaRTepl3ylolueeCH
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OHa BHCpBble 6bIJIa 3aperIICTp11p0BaHa B CILIA B 1924 r., a 1103AHee
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B 55-75? y6HBaeT er0 3a IICCHOJIbKO MHHyT, IIpHMOLI COJI11C4HbIH CBOT --
MOHCO MOM 3a 7 LIac013; Ae3HH(HI1;Hpy10H[He paCTBOPbI ACHCTByIOT
ry6HTeJIbH0 B OMellb HOPOTH11C CpOHH; oco6eHHo aHTHBeH CAKHH HaTp,
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4ICPe3 H01111OHHTHBy. OCTOHHHHOM 11Il(j e1iI1HH CJIy?HaT 60JIbHble H Hepe-
60JICBJIIlIe HTHIjbI, HOTOpble nocae BbI3AopoBJIeHHn OCTaIOTCR AJIHTCJIb-
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HHileCHHX CIIMIITOMOB pa3JIHiIalOT 4opMbI 6ojIe31IH: roMopparhl lecHylo,
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IiaTaparIbnyIO, AH(TepolAHyro II korl'broHnnTHBaJTbriyio; Ho AJIHTeJIb-
HOCTH Te JeHHH ona MOxceT 6bITb OCTpOH (3-6 AHefl), HOAOCTpor (2-
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peAKO rlepexoAcI B Apyrne c O Mbl 60JIe3HH.
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rHHepeMHpOBaHa, BJIan ua, 6yrpHCTa; B HOH'bIOHHTHBaJIbHOM MOHIKe
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JIeTaJIbHOCTb HpH JIapHHrOTpaXeHTe AOCTHraeT B cpeAHeM 15%;
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rOpTaHH 11 Tpaxee. OHH MOryT 6bITb BbrpaxceHbl 6OJIee HJIH Menee
pe3Ko, qTO 3aBHCHT OT HJIHHHTieCHOrO lpofJBJIeHHfr 6onIe3HH. B 3TIIX
opranax Ha6JrloAaIOT rHIIepeMHIO CJIH31,ICTbIX H HpOBOH3JIHfrHHH. rIpH
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CRoro HpHMeneHHrr. 06paJIkaIOT 000600 BHHMaHHe Ha CBOeBpeMeHHOe
18 M. C. rauaywKilu 529
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I1LIAC5e1I11e Ii H30JIM1111O 6OJIbIIbIX It IICpe60JICBHIHX, AOJIFOC BpeMH
OCTaIoaulxCFI BIIpyCOHOCHTeJIHMH. YJiyLIHIa1OT yCJIOBHH CO;[ep?uaHHH
11 HOpMJICHHH IITIIUbL
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(Neurolymphomatosis aviunl)
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3TIIOJIOPHH 3THX 3a603Ie13anlin eiue oKOH9aTCJIbIIO HC yTOTIIIeHa.
BOJIbIIInnCTBO HCCJIeJjoBaTerIen Bo36yJUITCJICM JlefH030B C'IHTaCT
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(JyIIICIIHYI upOBeTBOpeuHH it 1eHTeJIbHOCT14 pa3JIH'IIIbIX opraHOB it
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TBOPIIbIX opranax it nopa?KeIIHbIX THaHHX. OH yCTOu'InB H Jiy'IaM
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IIaH IITnlja IIpH COBMCCTHOM co epSHaHnf CC CO 3AOpOBOH. HepeijaT--
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B BO3paCTe 2-5 MeegAeB He3aBHCIIMO OT uOpoAbl; H 3a6oJICBaHHlo
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BOCIIpI4ITM'IJBbl TaRme (a3axbl n nHj;e13KII. I4HKy6agI3oHHui IIepnoA
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n11Ky6alunn 3T11 Hnua Henpnroj;nbl. BOJIbnyIO HeupoJIHM(IOMaTO3oM
IITnl;y He JlegaT.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I' aia XXIV
FOJIE3H14 COBAIC
1IWMA COBAI#
(Febris catarrhalis et nervosa canum)
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a npn HepBHbJX cJ)opMax uyMbI -- H B M03F0.
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HH(DEIfl 1IOHHbIE B0JIE3HFI MOJIOAIIfII{A
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
morn BHIIMaHH}I Tpe6yeT yxOA 3a IIynoBNHOii; OTpe3aTb ee cJieAyeT
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ha I10B0p0?HAO1IITbIX TCJIflT O6JIer~IaeTCfl TOM o6CTO5TOJIbCTBOM, tITO
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cpeAy H na OJZHy 113 3JIeI{THBHbIX cpeA (3HAo, Rpnra1lbcHoro H Ap.)
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
xopOHIee J[ellCTBHC Oxa3blBaeT CHHTOMHIkHH, BHaHaJIO no 0,5 r na 1 Kr
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HorO TpalTa. IIpH xpouHLIecHOM TegeHHH pa3BHBaeTCH Hopaxcerne
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ynoTpe6JIeHHH B nmiq MHca, Hx41HIJHpoBaHHoro 3THM MHKpo6oM).
MHKpo6 He Tpe6osaTeJIex B 0THOHieHHI HHTaTeJIbHLIx cpeA; Ha
MHCO-IIeIITOHHOM 6yJIboHe o6pa3yeT nHTOHCIIBHyIO MYTb H Ha J;He
cepo-6ennHII3 o6HJIbHbIH ocagoK. OH 6HOXHMHgecHH BecbMa aHTHBeH,
c6pa}KHBaeT C o6pa3OBaHHeM HHCJIOTmI H ra3a rJIIOKO3y H MaHHHT,
HO He II3MeHHCT cpeA I C JIaHT030H H caxapo3ol, LIeM OTJIHgaeTCH OT
MHKpo6oB rpynnbl KOJIH. B gu44epeHI HaJlbHOl3 pHarHOCTHKe HapaTH-
4 03HMX MHKpo6oB (rpynnbl Salmonella) cepbe3HOe 3HageHIIe HMelOT
cepoJIorH,qeclHe pealU Ul (PA) C THnocneI n(HnOCHHMH cbIBOpoTKaMH.
YCTOIILIIIBOCTb B036yAIITeJIH IlapaTH( a BO BHemxen epeAe BecbMa
3HaLIHTeJIbHa - OH M01KeT COXpaHHTbCa MecnIIaMn B HOLIBC, BOAe,
HaBO3e; in Hero ry6IITeJIbna BbICOKaa TeMnepaTypa, HaipHMep
npl 60? 3TII MIIKpO6hI IIOrII6aIOT LIepe3 20 MHHyT, HO HMelOTCa H 6oJiee
yCTOIPIHBble K HarpeBaHH10 IIITaMMM. 06bI'IHble JSe3HH(J)HI FIpyIOMHe
Ben(eCTBa HBJIHIOTC1 B OTHOIIIOHHH Bo36ypnTeJlen IIapaTIIC a aKTHB-
HbIMH B o6n[enpnHBTblx pa3Be);eHHHX.
ECTeCTBeHHOe 3apa]ICeHHe TOJIHT napaTH(OM npOHCXOJ;HT game
LIepe3 IIHII[eBapHTeJIbHbIH TpaHT, OJ;HaKO B03MO1KHa 13 B03JZyIIIIIO-
KaueJlbnaa HH(e1WHH, TaK KaH npn napaTH()e, B oCO6eHHOCTn hpH
ero XpOHHLIecl{OH (OpMe, Ha6Jno1 aeTCH nopa?Henne JIerKHX. TaKHe
60JIbHMe MOryT pacceHBaTb 3apa3HOe HaLIaJIo 1pH KauIJie H 1iH(HI1H-
posaTb oKpy?Kalou ylo cpeAy? 3apaxcenne BHyTpnyTpo6HOe n uepe3
IIynoBHHy BcTpegaeTC1 HaK pei(KOe HCKJIlOLIeHne.
HH(III;IIpOBaHHe tiepe3 nllu eBapIITeJIbH)III TpaHT HMeeT McCTO,
KorAa HenpaMHeHIIn H pyre BMIJ{eJleHHn HCHBOTHbIX IIpHCTaIOT K
nOJIy, cTenaM, oJ[emAe, H HHBeHTaplo 110 yXO)l;y H T. A. B 3THX ycJIO-
BHHX TeJIHTa norJIOmalOT 3apa3HOe Haganno, o6JIH316lsaa oHpymalo-
WHe npeAMeTbI, yHln H IIIepCTb CBOIIX COCe) eli (oco6eHHO nOCJle Bbinan-
BaHIIa HM Monoha), 1Kyn 1JlaTbe TeJIHTHHI;bI H T. A. Cnoco6 nOeHHa
c naJIblra Tal1Ke COJ(eHCTByeT B HeKOTOpbIx CJIyiIalX 3apa?KeHHIO.
Mffoq uHaMn HH(eHqHH cnny1KaT 60JIbHble TeJIHTa, BbIJ;eJlaloWHe
3apa3Hoe HataJIO BO BHOIIHIOIO cpeJjy rnIaBHhIM o6pa3oM C KajioM.
HpoMe Toro, 3Ty Me pOJIb MOryT I3rpaTb 3AOpOBble KOpOBIJ-6aKTepno-
HOCHTeJIH H Bb13J{opoBeBlnne TeJIHTa. Y HIIX MO?K T J[JIuTeJIbHOe Bpe-
Ma coXpaHHTbCH 3apa3Hoe Hatan10 n nepHOJ;IIiecHH BLIAeJIHTbCH
C HCIIpa?RHeHIIHMH.
KaHianweHne npIl3HaI1I 6one3Hu. 11HHy6aIZnoHHbin rlepllO na-
paTH(a TOJIHT npoJ;oJUKaeTCH OT AByX AO BOCbMH AHeH. Hpu 3a60Jte-
BaHHH TeJIHT CTapIBe MecaLIHorO B03paCTa 6oJIe3Hb 06bITiHO npOTe-
KaeT JIeI'I{0, MJIIITCR 3 -4 JcHn, npOnB 1neTCH $ 06u eu BaJIOCTH, B
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
yMeHbIHeHHH alTeTIlTa, JICrROM HOCJIa6JICHHH, I{paTHoBJ)CMCHIIOM
I10J'6CMe TCMilepaTypbl go 40? H 3aHaIIMHBaeTCn BbI:3J~OpoBJI0IIHeM
(a6opTHBHaf1 (IOpMa).
0 C T p a n c o p m a IIapaTH(ia, Ha6JIIogaeMaH Y TCJIHT B Bo3paCTe
go 3-4 110,gCJIb, - TH2IcejIOe 3a60JIesaliHe. 0110 HagnnuaeTcfl IIOBbI-
I eiirieM TCMHepaTypbI go 41?, HiIOrr a 031Io60M; Oj[HDBpCMCHHO yCTa-
HaBJIHBaIoT paccTpoLICTBO Cepge'moii AeHTeJlbItOCTH (HyJ1bC 110-150
B MHI1yTy H IiepeAno apIITMa HbIfJ), yuamenHoe JI,bIXa1IHe (go 60-80
H 6oJlee B MHHyTy) 6pIOlUllOr0 THHa, cepo31Ib1A ICOH'LI0IHnTHBIIT.
Pxc. 159. HapaT4 TeJIf1T: OByxBI1Ie cycTaBM.
TerieiioI{ yrHeTCI1; OH Bfn io pearnpyeT Ha onpyaxaloMee, 6oJrbllle J10-
M1 1T, HOJ[HHMaCTCH HCOXOTIIO, LlacTO COBCpHICHBO OTHa3bIBaeTCH OT
CBDCI3 nopiwHH MoJIoIa. Ha 2-3-fl ACHb 60JIe3III4I{OIICTaTHpyIOT pac-
CTpo iCTBO gefTeJIbHOCTH I{HIIJOgJHOrO TpaliTa: nail CTaHOBHTCII MITg{HM
H CJIH314CTbIM, 1ICCJITOr0 HJ1H CepO-If eJITOro IUBOTa, HpOTHBHOro 3aIIaxa,
Hpoln3allHbIM HHOrga Hy3blpbl#aMH ra3a; B pO HHX CJIytianX OTMe-
uaeTCfl HpOC)y31ILIi{ HoxoC. HpH o=IelIb THalceJroM TcuenHH HapaTHC a
HOHBJIfICTC5I PHA CHMHTOMOB, yIia3bIBaJOMIIX Ha HOpaaHCHHC HOqeii,
MOtfeuCHyCHaIIHe CTaIIOBHTCn gaCTbIM, 60JIe3I1eHI11,IM; B MO O HaXOA}IT
6eJiox H gpyrue HaTOJIorimecICHo 3JIeMeIlTbl. Teuenon{ JTOaHIIT, 110
pearlpycl IIa oxpyxcalowee, y HCro me BpeMfI y;jepalcHBaeTCfi BbICOifax
TeMHepaTypa TeJ1a, H ncuBOTHOe Horn66aeT Ha 5-10-n geilb.
B J1erHHX CJIyuanx HapaTH(f a Hpu311aKH 60JIC3H11 HOCTeneHHO
cMfIrgaloTCfl, HpeICpawaeTCH 1I0110C, HoCTelleHllo HaJJ;aeT TOMHepaTypa,
MHBOTI10e MWEeT Bbl3JJOpOBeTb, 11 111 6oJIe3Hb IIplHHMaCT xpOHHTICCICyio
(f OpMy.
HpH xpoii ii ecnofl (J)o pMe 60JIC3HeHIIble 5IBJICH1IH CO
CTOpOHbI aECJIyZ(OLIHO-1fllIIIogIHOrO TpaI{Ta IIOCTCIICHHO ocJIa6eBaloT
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B CBOeii HHTencHBHOCTH, HO BMeCTe C TOM rIOHBJTJIIOTCI1 HpH3HaICH Ho-
pa?xeHHH opraHOB j[bixaHHH. BHauajle Ha6JIIoj{aeTCH CJIH3HCTOO, a 3a-
TOM CJIH3HCT0-rH0HH0O Bblj(ejieHHe H3 HOCa, CyXOH HaIUOJIb, ROTOpLIII
C TOIIOHHOM BpeMeHH CTaHOBHTCII BJIaIHHbIM, YaCTbIM H MyiIHTeJIbHLIM.
IIOCTeneHHO HapaCTaIOT CIIMHTOMLI HHeBMOHHH, IITO BJIegeT 3a CO6OH
HOBhIIIIeHHe TeMHepaTypbI TeJIa. IIyJIbc geiiaeTCH CJIa6biM, apHTMHII-
11MM, a CepjLel1HblH TOJIgOH CTytaIWIM. BOJIbHOII TOJIeHOR 60JI161HyI0
IIaCTb BPOMOHH TIeMHT. OAHOBpeMeHHO Y HOrO A0BOJIbHO LIaCTO OTMe-
IIalOTCa BOCHaJierne CyCTaBOB H XPOMOTa Ha 6o3rbHyIO HOry. B OT-
AeJIbHbIX CJIyIIaHX BOCHaJreHHe CyCTaBOB COXpaHIIeTCH H Torj[a, Horga
OCTaJIbHbje 6oTIe3HOHHbie HBJIOHIIfI IICIIe3aI0T H ?THBOTHOe Rau 6yj;T0
IIaIIHHaeT BLI3AOpaBJIHBaTb.
B BRAO HCHJIIOYCIIHII BCTpetaeTCH Tau Ha3bIBaOMa$ H e p B H a fig
HTIH 3RJIaMHcHIIecUaH, (f opMa HapaTHCfa. BoJImHOHTe-
JIeHOH HaTbIHaeTCH Iia HpOHTTCTBHII, 6e0003uaTeJIbH0 7ABK?HeTCfI no
Rpyry, HaJ aeT, HOCJIe Irero MOrYT BO3HHHHyTb CyAOpOrH.
IIaTOJIoroaHaTOMHIIeCKIIe H3MelleHHH. OCHOBIrbie II3MeHeHHH HpH
OCTp0I3 ( opMe JIOHa1IH3yI0TCH B ?ReJIyA01IH0-KHIHetH0M TpanTe. CJIH-
31ICTaII o60JIo*IHa CBIlryra H TOHHHX RHIIIoic BOCIIaJIOHa, B HOAB3j;0HIHOH
UHIIIRO *IaCTO HaXOAfIT (3H6pHH03Hble HaJIOxceHHH. Me3eHTOpHaJlbHbie
JIHM4 aTH*IeCRHe y3JIhI Ha6yxmHe. B 60JIbIHHHCTBe cnlygaeB o6paluaeT
Ha ce6H BHHMaHHe Pe3HOe YBOJIHI CHHO CeJIe3eHUH (B 2-3 11 6oJIbnue
pa3). OHa IiaCTO oKa3bIBaeTCH repo-HpacHoro, BHIIIHeBO-upaCHOrO,
a HHorAa HOIITH IlepHOro r BeTa. Hog UalICyjioii 3aMeTHbI TOLIO IHbIO
HJIH HIITHHCTMe RPOBOII3JIHHHHH, a B HapeHXHMO opraHa - 3aLIacTyio
McJIKHe HeHpOTHLIecuHe (IOUyCbI. Ilenexb HpH 3aTn?uxoM TeIeHHH
6oJle3HH yBeJIHIreiia; ITBOT ee rJIHHHCTbIH mm 6yp0-Cepmi , PHCyHOU
Ha pa3pe3e criiaxceH. T4aCTO B HeIeHH HaXOAHT ?ROJITOBaTble o a?HRH
Hexpo3a.
HpH XpOHHIIecHOIi (OpMe MOryT 6bITb H3MOHOHHH B JIerHHX.
,JHarH03 CTaBIIT Ha OCHOBaHHH HJIHHHHO-3IIH300TOJIOPHIIe6RHX H
HaTOJloroaHaTOMHIIeCRHX gaHHbIX H HOj;TBepIT aIOT 6auTepH0JlorH-
IIOCRHM' IICCJIe) OBaHHeM. Aim AHarHO3a HMeeT 3HaIIeHHe B03paCT
3a60aaCBHIHx (or 10 go 30 AHeH), BHe3aiiHOCTb 3a6OJleBaHHH, HOCTOITH-
HaH BLICoHan JIHXopaj(Ra, paccTpoIicTBO RHHIeIIHHUa; HpH XpOHHIIe-
CROM TelieHHH - HofBJIEHHe CHMHTOMOB HopanfeHHII JieriHx. Cepbe3-
IIyIO HOMOII]b B HocTaxoBRe AH(t(epeHgHaJlbxoro AHarxo3a oua3bIBaeT
BCUPbITHe HaBHIHX TeJIfIT.
BaHTepHoJlorfliecnan AHarHOCTHRa HpHMepxo TauaH ne, Rau
HpH RoJT16ailHTITIe3e. IIpu gHarxoCTHHe HapaTui a 60JIbIIIoe 3Ha'Te-
HHe HpHgalOT cepoJlorHtecHHM peanuImM (PA).
JIeIIeIIHe. Aim ge3HH(eH1>HH HHHIegHHHa HCIIOJIb3yIOT CaJToJI,
TaIIaJIb6HH (0,5-1,0) HJIH RaJIOMeJIb. IIpH HeJ OcTaTOIIHOI3 geHTeJIb-
HOCTH cepgiTa Heo6xogHMbi rlogRO?RHbie HrrbeHIZIIH HaMC)apxoro. Macmra
(5 MJI), Ro(eHHa, HpH B03HHHH0BeuHH IIHeBMOHHI3 - BHyTpHBexxble
HHbeRAHH 33-r1poi eHTHoro pacTBopa CHHPTa (20-30 MJI), cRHHH-
Aapa (0,3-0,4 MJi) HTIH HoBapcexoJla (0,02 cyxoro HperiapaTa Ha 1 Hr
MHBOFO Beca R11BOTHOrO pacTBOpnIIOT B 25-50 MJI RHHFIIIOHOIi BOj[bl).
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
3aAaIOT Taxaxe BHyTpb cyJlb(aHTpoJI 4 AHn no pHA. B uepnblii AeHb
A03y onpeAe3HIOT n3 pacqeTa 0,2 na I Hr Boca TeJleHKa Ha 3-4 npneMa.
Ha Apyroi if nocJIeAyiOIIj1Ie AH11 A03y Ka?KAblli pa3 yMCHbHIaIOT
Ha 1/4.
C JIeLie6HOH IjeJIbIO MO?KHO 1CBOJIb3OBaTb 6HBaJIeHTHyI0 KOJlnnapa-
TH4JO3HyIO CbIBOpOTHy B ICOJIH'IecTBe 60-100 MJi noA116HiHO (Hpu HO-
o6XOAHMOCTH HH'beii(HIO nOBTOpHIOT) n cueiAu HLIecICnil 6aKTepuo(ar,
HpilMCHCHRO KOTOPOFO 110 Bewi otIaeT CHMnTOMaTHgeCKOFO JIegennH,
cepoTepanHn n Apyrnx McPOHPI4HTHII u0 yJlyLIiueiiulo ycJTOBHYI co-
Aep?KaHnn n xopMJlenun MoJioAIIHHa.
(DarOTepallun OKa3bIBa0T MaKC1MaJIbHbIii 3(4eiT, CCJln IC Hen npn-?
67~eraIOT C lIepBbIX 'IaCOB 3a60JieBaHnn. CXeMa JIeLICHUH CJleAylollkan,
1JomIbHbIX BbIAePHHHBalOT iIa FOJIOAHOii AIIeTe 4-8 ilaCOB, He Jlniua1,
OAHaHo, TeILJIO1I KnniileHOn BOALI. HocJie 3TOI'O uM 3aAaIOT tlepe3
POT 3 pa3a B Ae1b, C AByXLIaCOBbIM11 npOMe?KyTKaMI, 6aKTep1Io al'
B AO30 30-50 MJI 11a OAHH 1PneM, B 3all1CHM0CTH OT Boca a BO3paCTa.
HeIIocpeACTBeHIIO nepeA nCnOJIb3OBaH4eM 6aKTep10 ar pa3BOAHT
B 100 MJI KHuHL1OHOll BOAbI, OCTy?KeHHOH Ao 20-25?. B TH?KeJIbIX Icjiy.-
gaax napaTll a KOJIHLICCTBO 6aKTepno(ara Mo?KeT 6bITb yBeJlu'leHO
Ao 100 MJI Ha OAIIIi npHeM. ,To Aa'in (al'a ?KJBOTI1b1M BbinanBalo?Tr
3-5-upolleHTIIbIiI pacTBOp cOAbI Ha KHIlBgeHOIi BOAC B KOJIUtIeCTBe
25-30 MJI H nciullo'laloT 143 KOpMOBOIO paAnona HnCJIble KopMa.
Houle TpeXAHeBHOrO JIOIICHUH HOO6XOAHM IlepepbIB na 1-2 CVTOK,
H B cJiyilae HenOJIHOro Bbl3AOPOBJIeH14s JIOTieHue IOBTOpHIOT. B TH?Ke-
JIbix CJipIaax AonycHaeTCH BBeAeHne 6aKTeplo4ara 1OAKOHSHO HJIll
BHyTp1MbIIIIeLIHO B Ao3e 30-50 MJI oWHH pa3 B CyTKU. HOBTOpHai uH beH-
BHH Bo3MO?KHa TOJIbHO iepe3 24 maca. HpH Jleilennn 6aKTepHo(iaroM
uepe3 POT He peno eHAyeTCn O)AHOBpeMeHHO AaBaTb CJIa611TeJibHble
11 Ae3uH(Ju1jupyIOMne BeLI1;eCTBa.
CxeMa iiewHuu aHTn6noTnnaMu (CUnTOMiinunOM H 6uoinuiHor)
Ta MC, LITO H Hpn KOJIn6aAHJ1Jle3e. Hpu napaTn4)e noKa3alio HpuMeHe-
Hn0 ABH.
Hpo4niJlawTnxa H Mepbl6opb6bl. B xo3alicTBax, rAe nonBUJICH napa-
T144) TeJInT, 60JIbHbIX H nOAo3puTeJIbHbIX HO 3a6OJIeBaHuIo HfuBOTHbI:K
113oJl14pylOT. MecTa, rAe OHn HaxoA1JTHcb, A03uH(11L[11py10T. BMOCTO
C TOM o6paJ1 aIOT cepbe3HelIHee BHuManue Ha yJiyqlueuue yCJIOBnl
coAep?1caHHH TeJIHT, uX HOpMJIeH1H n yxoAa 3a IIHMH. AJIH yCTaHOBJIC-
Him 6anTepnoaor1I ecKoro AHarl103a OTHpaBJIHIOT B Jla6opaTOpnlo
AJIH IICCJIeAoBanun B11yTpeHllne opranbl naBBIero TeJlenna: cepAiw,
JleI'Hue, negeHb, CeJ1e3eHKy, JIHM(DaTugecnue y3JIbI, oco6enHo Me3eH-
Tep1laJlbHble, Tpy6LlaTyI0 KOCTb 11JIll BOCb TPyn L eJIHKOM. /JI} BbIAeJIH-
eMbIX TOJIHT B XO3HHCTBe AOJI?K0H 6bITb o6opyAonaB. Cne1);uaJIbHhIn
H30JIHTOp.
B KaneCTB0 MOP CneIuI4111 ecEoA npocllIJiaKTnnn IIpFMen}IOT
6uBaJIeHTHyTO CbIBOPOTKy npoT11B KoJIn6a1jHJIJIe3a if napaTn4)a; 4J0p-
MoJIBaKLAnny napaTf()a TeJIHT n 6aRTepno(S)ar. 3AOpoBbIX TejilT C npo-
(mHJlaKT1I eCn0ii I);OJIbIO 1PHB14BaIOT CbIBOpOTKOlI B Ao3e 30-40 MJI.
BaHTepuo~ar 1icuo b3yIQT C nepnoro AHS po?KReHHi AQ 'IeTbipCXMe-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
csitlrrro no3pacTa TpexxpaTHO, C HHTepnanoM B 5-7 AHeii. Ero HBO-
ART qepe3 POT HaTOHJaK, 3a 2-4 data go KopMneHHfl, B A03e 20 Mn.
B CTaqHOHapxblx o'iarax HapaTH(f a A1B yHHiITOxceHHx 6aHTepHOxo-
CHTenbCTBa peuoMeHAyeTCH AaBaTb 6aHTepHo(far per os H B3pocnbMM
}HHBOTHbIM (CTenbHnIM H AOHHLIM HopoBaM) TpeXHpaTHO, c IIpOMe?icv-
KaMH B 5-7 AHeii, B A03e 30-40 Mn. HopoBaM 3a 1-2 AHH AO OTena
6aRTepHol ar B TOH xce Ao3e AaIOT enge pa3.
(DOpMOJIBaHr Hno BaXAIIHIIpyIOT TOnbRO 3AOpOBSIX TeJISIT, C HOp-
ManbHOH TeMIIepaTypoH, B BO3paCTe OT 3-5 AHei go 3-4 Mecni eB.
HpHBHBKa DOAKOaxnaa, AByxpaTHax, C HHTepBJJOM B 3 cyTOK, B Ao3e:
IIepBasl 0,5-1,0 H BTOpafi 1,0-1,5 MJI (B 3aBHCHMOCTH OT BO3paCTa
MHBOTHOro). Ha McCTe HHbeKAHH MOHSeT o6pa3OBaTbcfi He3HatIHTeJIb-
Han oTegHOCTb, KOTOpag nerHO paccaChIBaeTCfl. Pears nri Ha BaRgHHy
o6bJLIHO HacTynaeT sIepe3 1-8 gacoB IIOCne HHbeHIZHH H BbIpawaeTCfl
B KpaTHOBpeMeHHoM IIOBMIHIeHHH TeMnepaTypbl, o61geM HeAOMOraHHH,
BHJIOCTH B ABHHfeHHIIX, nozepe HJIH yMeHbIHeHHH anneTHTa. Hpi
ynauue cepAeLIHoii AesTeJIbnocTH pearHpyiownM TenHTaM Heo6xoAHMO
BIIpbICHyTb HOAKO?HHO KaM(apnoe Macno (Ao 20 r) HJIH KO(eHH.
HMMyHHTCT HacTVIIaeT Ha 10-H AeHb IIOCne BTOPOi IIPHBHBKH H IIPO-
AonxcaeTCH AO HSTTH McCHACB.
TeJIHTa, IIOAO3pHTeJIbHbie HO 3a60neBaHnIO HapaTH(OM, a TaiH(e
60nbHbie, cna6ble H HCTOH[eHHwe HPHBHBaIOTCH TOnbHO CbIBOPOTHOII
B Ao3e go 40-50 Mn. B cnytlae Heo6XOAHMOCTH BBeAeHHe CbIBOpOTKH
IIOBTOpIIIOT.
CpeAH npeAynpeAHTenbHbIX Mep IIPOTHB IIapaTH4a TeJIRT BaMHoe
McCTO 3aHHMaeT BbIfIBneHHe 3AOpOBMX HopoB - 6aHTepHoHOCHTeneI3
iiapaiHf a nyTeM HccJIeAonanxn HX KPOBH peaHgHeI3 arrIIOTHHagHH.
BaRTepHOHOCHTeJIH AOJIMHN co)epHfaTbcfl oTAenbHO OT o6uAero CTa)a
II HMCTb oco6oe pOAHnbHOe noMei eHHe. HpHIIJIOA OT HHX BSIpaWHBaIOT
o6oco6neHHO.
B IIenfix up0(HnaHTHKH I opMOJIBaRgHHOH MO?KHO BaKI;HHHpOBaTb
H CTenbHLIX KOpOB.
AHIIJTOROUROBAH HHOERIIThI TEJUIT
OnpeAeJlenne 6oae3HH H ee Bo36yAHTeab. ;HIInOMoiKoBas HH-
I eHIwn HpeAcTannneT co60IT 3apa3HOe 3a6oJIeBaHHe MOJIOABIX TenfIT,
KoTOpOe 06M'IHO HpoTeKaeT ogeHb OCTpO c HBneHHHMH cencuca H
BocnaneHHII cyCTaBOB. LHHJIOKOKHoBal HHC eHI.[HH MomeT Ha6nioAaTbcst
y B3POCnTIX EHBOTHI,IX, IIPO$lBJIHRCb McTPHTaMH H MaCTHTaMH.
Bo36yAHTeneM 3TOH 6One3HH CLIHTaeTCR AHIIJIOKOHH (Diplococcus
lanceolatus); B Ma3KaX H3 opraHOB OH npeACTaBnfieTCH napHBIM HOK-
KoM narn eTOBHAHOI3 MIR OHpyrJIOI3 4 opMbl, xopoino KpaCHTCJI o6br's-
HbIMH KpaclaMH, a Taisse no FpaMy. Terra KolKOB oxpyTKenbl Kan-
cynOi; IIpH OHpacHe Ma3KOB, c)enaHHnIx H3 KynbTypLJ, Hancyn
O6bILIHO He Ha6nl_OAaeTCfl.
,IJIII KynbTHBHpoBaHHfi MHHpo6a JIygmeH nHTaTeabHOH cpejofi
CLIHTaeTCH IIOnyHiHARuii arap, B KOTOpOM AHIIJIOKOKHH paCTyT B BHAO
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HCHCHbIX, pacnOJ109C0II11bIX B I1117KIIC1I tIaCTll CpeAbl XJ10II1.CI3. Ha MBCO-
HeHTOHIl0M arape AHIIJ1oKOR14II oOpa3yiOT MerIKHC, Hpoapatmble, 1{pyr-
11bIC Konoii1ni iianoAo6HC KaIICJICK pocia; HPH pOCTO B MHCO-BCIITOH-
HOM 6yimoHe IIOHBJIHCTCH paBIIOMOpHOe lIOMyTIIC1IHe cpcAbI C 1ie6OJIb-
Bu M ocaAKOM Ha AHe Bpo6lpKII.
LHIIJI0KOKK 06JIa;AaCT 60JIb11101I 61TOXHMIIgecK011 aKTIIBHOCTbIO,
yCTaHaBJIl1BaeMOH Ha cpe ax c caxapaMII.
YCTOIIgHBOCTb 13036yAHT0JIH HenucoKaf ; 06bh llble AO3HH(JhIIqH-
pyioiii ie cpeACTBa 06e3Bpe}KIIBaIOT ero H HOpOTK11e cpOKH.
H AHBJIOKOKKy 113 JIa6opaTOp11b1X ?ICHBOTHbIX OCO6e1111o zIyBCTBII-
TCJIbllb1 MbIIBII, MCHCC BOCIIp1111Mt1HBbI MopCKIIe CBIIIIKH H KpOJIHKH.
CIIOCO3bI 3apa?1tieHIIR. 3apa?KCHHe AIIIIJIOKOICKOBOH 1411(CEaH011
IIpoIICXOAIIT, 110-BIIAHMOMy, uaiiAe aaporeBIIbIM ByTCM. YCTaH0BJI0HO,
qTO HOCOBan CJIII3b H Moqa 60J1bIIbIX B 60JIbIIIOM KO1IIIg0CTBe COAep-
?KaT 3apa3110e IlalIaJio, HOTOpOO I1OHBJIBCTC31 B 3TIIX BbIACJICIIIIHX V?Ke
Ha 2-3-H ACIIb 3a60JIe13anHH. I3o3M0?KIIO 3apa?KeH11e H ilepe3 IIyBO-
Bffi1y.
I13BOCTIIyIO pOJIb B paCUPOCTpaHCHIl11 B036ygIIT0JIn 6oJIe3HII
MOryT 11rpaTb B3poc1Ible KOpOBbI, KOTOpbIC C Bb1AeJIOHHHMII H3 BJlara-
J1HH1;a Ilp11 MOTPHTaX H C MOJIOKOM HpH MaCTHTaX pacceiBaIOT MHICpO-
60B H 3apa?KaloT oxpy?Kalo14He IIpeAMOTbI.
npH311aHH 60JIe3H11. HHKy6al of i1b111 IIepHOA paBIIHeTCH HecKOJIb-
KHM AIIflM. HepBbTM CIIMHTOMOM 3a6OJI0Bau lfl CJIy?KHT IIOBblIIIClllle
TCMIICpaTypbl Ao 40-420 ; oAIIOBpeMeIIIIO oTMCgaeTCH yuaiueHHe IIyJIb-
ca H I OARTIeCTBa AbIXaTeJIbI1bIX A13II?Ke1111II. CO CTOpOHbI rJ1a3 Ha6n1o-
Aa1OT 1'HIICpeMHIO KOJILIOIIKTHBLI H o61111bIIO0 CJIe30TeWH11e. C IIapa-
cTaHBeM yrIleTellI101'O COCTOHBHH Y TeJie11Ka yMCHb1IaCTCH H 3aTCM
BponaAaeT anHeTHT.
3a6oJieBaHIIe IIpoTenaeT ouelIb OCTpO it o6bltIIIO IIa 2-541 Aellb
3axaH'IHBaeTCH CMepTbIO.
HorAa 6oJIe3Hb pa3BHBaCTCf1 MCIIee OCTpO, TO Ha oAIIOH, TO Ha Apy-
rOII KOIIegTIoCTII HepeAKO IIoHBJIHIOTC}I apTpHTbl, a co CTOpoxbI HihlJC 3-
I1HKa - imorAa Iiolloc.
B OTAeJIbhIbIX cJIy'IaflX Ha6JTIoAaIOT lIOAocTpoe II XpoH11ilecnoe
TCIIel311e 6 0 11 0 3 1111, KOTOIOC XapaUCT0P113y0TCH Hp1311aHaMH, yna3blBalo-?
rg11M11 Ha IIOPB?KeHH0 AblxaTeJIbxoro armapaTa, a HMeHHO: COpO3HO-
CJIII3HCTb1M IICTC'ICHIICM 113 HOCa, xa1IIJ1eM; HpH 13bICJIyIIIHBaHII11 rpyA-'
HO1I KJICTK I KoHCTaTllpyIOT xpHIIbl 11 6poHXIIaJIbHOe AbixanlIe, 11pii
HepHyccBH - OHarH IIpHTyIIJICHHH, B ocO6exxocTH B IIepeAIIel3 AOJI0
Jierxoro.
XpOIIHLieCKafl c OpMa AnlJIOKOKKOBOH HH(JeHIAIIH C }IBICHIIHMII
IIHCBMOHIIH BclpeilaOT011'JIaBHbIM o6pa3OM y TeJTHT cTapiUHX B03paCT011
11 IIPOTCKaeT 6oJI0e 111111 MCHee Ao6poKaueCTBdHIIO, Hepe)AKo onaHiI11--
Ba2Cb BM3AOpOB1IeHHCM.
HaTOJloroaHaTOMIIgeeHIIe 113MCHeHIIH. IIp11 BC1CpbITIIH HBXOAflT
R THIIy reMoppariilecnoH ceHTHACM111I. 13 OCTpbIX CJIy-ianX Ha6Jiio-
AaloTCa KpOBO1I3JIHIIHHH HOA IIJIeBpOH H 6p1ouhHH011, IIpH IIOAOCTPOM
11 xpO1l11CCKOM T09CH1111 - IIHCBMOH11H.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BecbMa xapaJCTepHrITI BHA HMeeT CeJIe3OHHa; oHa yBeJIHTIOHa B
1'/,-2 pa3a, BHHIHeBO-TIepHOrO ABeTa, C TOLIe'IHbIMH HJIH IIHTHHCTbIMH
HpOBOH3JIHHHHHMH IIOA HariepioH. HO CBOeI HOHCHCT'~7eHB;HH oHa
HanOMHHaeT Hay~IyH (OHa IIJIOTHa, HaH HyCOH p03HHbI). t11HHIb B peA-
HHx CJIytIanx 3TH H3MOHOHHH ce3Ie3eHHH OTCyTCTByIOT. CJIH3HCTan
o60JIOqI{a eMiIyra 11 TOHHOPO OTAeJIa HHHIe'IHHHa HpadlaJI, C HpOBOH3-
JIHHHHFBMII.
JIHarH03 IIpeACTaBJIHOT H3BCCTHble TpyAHOCTH, TaH Hai 3Ta HH-
(JCHAHH HanOMHHaeT pyre 60JIe3HH TeJIHT.
BaHCHOe 3HaqeHHe B AHarHOCTHHe HMCIOT HpH1HH3HeHHOe 11 110-
CMepTHOC 6aHTepHOJIOrnLIecioe HCCJIeAOBaHIIe HpOBH H HaTOJIOro-
aHaToMHtreCHan HapTHHa (MHO}HecTBeHHMe HpOBOH3JIHHHHH H
, oeei) . . . . 250
HeKpo6agnnne3 noBlaAeli . . . . . . . . . . . . . . . . . . . . . . . . 250
Hexpo6aIHnne3 Hpynxoro poraTOro ciOTa . . . . . . . . .. . . . . . 251
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Hexpo6auHaae3 CBHHeii . . . . . . . . . . . . . . . . . . . . . . . . . 252
Heupo6aunanea cenepimix oaeHen . . . . . . . . . . . . . . . . . . . . 252
Heupo6auunne3 xpon11iOB . . . . . . . . . . . . . . . . . . . . . . . 252
Heupo6aunnne3 xyp . . . . . . . . . . . . .. . . . . . .. . . . . . . . 252
JIenTOC1111po3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 254
IIacTepenne3bl (reMopparimcxan cenTHueMHa) . . . . . . . . . . . . . . 264
HacTepeane3 poraToro CHOTa . . . . . . . . . . . . . . . . . . . . . . 266
Hacxepenne3 cnHHeH . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Xonepa (nacTepennea) IITHI . . . . . . . . . . . . ... . . . . . . . . . 271
HacTepenne3 xpoanixoB . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Ty6epxyne3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 278
HCeBAoTy6epxyae3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
HCeBAoTyGepxyne3 oneu .. 293
HcenuoTy6epxyne3 xponnxon .. . . . . . . . . . .. .. . . . . ... . . . 294
ART LIH O M 11 x 0 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295
lip yuenne 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297
CTpnrymn4 unman . . . . . . . . . . . . . . . . . . . . . . . . . 312
TyJRpeMHa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 318
Hu[yp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
Be MOHCTBO . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . 332
Ocna .................................... 341
Ocna oneu .. . . . . . . . . .. . . . . . ... . . .. . . . . . . . . . . 342
Ocna xopon . . . .. .. . . . . . . . . . . . . . .. . . . . . . . . . . 345
Ocna norna,'[eii . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 346
Ocna cmmeu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 346
Ocna xoa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 347
Boneanb Oxcemxn (no>mHoe 6emencTBO) . . . . . . . . . . . . . . . . . . 348
rnaea XX. 3apaaHMe 6oae3Hn aomaAei . . . . . . . . . . . . . . . . . . 355
Can ..................................... 355
3nnaooTH'IeCHHn nHM(anronT (a4pnHancHnii can, 611aCTOMHHO.3) . . . . . 369
IIHC euunoHnbiH a6opT aomauei . . . . . . . . . . . . . . . . . . . . . . 374
MblT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379
HoHTarnoauan H.1eBponHeBMOHlH nomaAei . . . . . . . . . . . . . . . . 385
3apa3Hbii uaTap BepxHHX AbixaTeabHbix nyTeH . . . . . . . . . . . . . . 395
HH4ienunonnaa 6ponxonuenMOnnH nomaAeii . . . . . . . . . . . . . . . . 399
1411nloaHua nomaAeH . . . . . . . . . . . . . . . . . . . . . . . . . . . 404
Fpnnn aomaAei (uu aloaHuenoAo6Hoe aa6onenaune) . . . . . . . . . . . 409
IInTHnCTbtn T14c1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 412
3rjnaooTw iecxnu anuec)anoMHenuT noma;ef . . . . . . . . . . . . . . . . 414
14HCieuunouuan aueMna aomaAeii . . . . . . . . . . . . . . . . . . . . . . 431
r/taea XXI. Boneaun poraToro CHOTa . . . . . . . . . . . . . . . . . 432
IIapaTy6epuyaie3 xpynuoro poraToro CHOTa . . . . . . . . . . . . . . . . 432
3M41113eMaT03Hb1H (myMamun6) xap6ynnyai . . . . . . . . . . . . . . . . . 439
3apa3HbiH uaTap Boaranuma, 11.111 Huc)emwonnbIH BarHHHT, xpynuoro
poraToro CHOTa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 445
11onaabuoe BocnaaeHHe nerRHx (HBJ1) upynnoro poraToro CHOTa . . . . . . 448
3noxagecTnet1Haa HaTapanbHan ropy=nca xpynuoro poraToro cuoTa . . . . 456
LIyna xpyHHOrO poraToro cxoia . . . . . . . . . . . . . . . . . . . . . . 458
5 558
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HH iexunoHxJJH MacTHT onelt . . . . . . . . . . . . . . . . . . . . . . . . 464
IIHC exulioHHan IIJIeBponHeBMonHI xo3 . . . . . . . . . . . . . . . . . . 468
BpaT3oT OBeI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 471
HHC eRInoHHaH 3HTepoTOxceMHn oBeu (pa3MHr^ieanai no'ixa) . . . . . . . . 473
HH iexuuOHHaa aranaiTHH x03 H OBeu . . . . . . . . . . . . . . . . . . 475
I' iaea XXII. BoneanH CRHHeil . . . . . . . . . . . . . . . . . . . . . . 481
4yMa c 13HHei3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 481
Poaca CBHHeIi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 495
HapaTn4i cBl HeFl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 502
3HaOOTWYecxax 6poHxoHHeBMOHnn (rpnnn) nopocxT . . . . . . . . . . . 508
1Ixcr03HIa cBlinel3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 511
Faaea XXIII. Bone3Hn IITHU . . . . . . . . . . . . . . . . . . . . . . . 513
BarHJIJInpHI>Ii3 6enbii-i nonoc IUIIJIHT (nynnopo3) . . . . . . . . . . . . 513
9n4ITepuT-ocna xyp . .. . . . . . . . . . . . . . . . . . . . . . . . . . . 518
LIyMa HTHL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 522
IIH(CHJIIOHHMIH JIIlpniirOTpaxelT xyp . . . . . . . . . . . . . . . . . . . 528
HenpoJInM ioMaT03 HTIIU . . . . . . . . . . . . . . . . . . . . . . . . . . 530
I'naea XXIV. BoJie3HH co6ax . . . . . . . . . . . . . . . . . . . . . . . 532
'IyMa co6ax . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 532
F4aea XXV. HHC IexunoHHi ie 6o.Ie3HH Mo.Io; Hnha . . . . . . . . . . . 538
Bemiaiii nonoc COC HOB (xonn6aunnnea) . . . . . . . . . . . . . . . . . . 539
HapaTnc TenxT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 542
AnnnoxoxxoBag HH(iexunn TeJIHT . . . . . . . . . . . . . . . . . . . . . 547
CenTH4ecxax IIneBMOxnu TenxT . . . . . . . . . . . . . . . . . . . . . . 550
HapaTHCJo3Haa nxc a}WHH acepe6wT . . . . . . . . . . . . . . . . . . . . 552
HnocenTHgeMnx acepe6nT . . . . . . . . . . . . . . . . . . . . . . . . . . 553
CTpeIITOxoxxoBaa Hnn)exiInn (cycTaBoJloM) acepe6aT . . . . . . . . . . . 554
An3eHTep HH xrHHT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 555
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Pauulluiuum Mameeu CU MO%oeu4
0I114300TOJIOrnfI C OCH013AMII
MHICP OFHOJIOI'IIII
PegaxTOp A. C. Conoee1
Xyno.nnnn H. A. Banbveccruu
XyT(OMe. Tnennhlll penaicTOp II. M. Xoxpima
Texnrigecnnii pe7ianTOp A. H. Ea/uio8
ICOppenTOpbr E. H. H1L%oecna.' n M. P. q)eux6epa
Cnano n iiaGop 22/X1 1957 r. Ilonnncano x ne iaTn
14/11 1958 P. T 00/i64.'DOpMaT 60 X 92 i/te. He. Ji. 35.
YY.-n3R. ai. 36,87. Tupa>n 25 000 3n3. 3axa3 N 1008.
Rena 10 p. 20 n.
Ceilhxoarn3, Mocnna, B-66, 1-i3 FacMannbii nep., 1(. 3
Jlennarpa;Icnnil ConeT napomlloro xo3nuiCTaa
Ynpanaeime ItoJnrpacpnvecHOil npombnT[ernrocTl.
Tnnorpa?nn J\ I elle'taTnbiii Jlnop> nMetln
A. Al. FopbIIOro. Jlennnrpa;k, PaTVnacxan, 26.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
IIpeBpaII exrre
yraepoAa
Ao Hagana
IIpeapargea1Te
yrneBO)OB
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
E.C.4EPKACCK14L4
9YMA
IIAOT.0'31AHbIX
M3AATEAbCTBO UEHTPOCOI03A
MOCKBA ? 4957
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
E. C. 4EPKACCKHI%I,
OOKmop eemepuHapHb x HayK, npo66eccop
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
.411HOTALI14Y
Kit III ii Hp(' iCTaB:IlCT Moi orpa(I)Ino, OCBellliIlo IJlytO ^ah()UJR UhIbI}
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II mnpOKO npn.I 1i5ICMbIX It CCCP.
K,611ra paccvBTaHa Ha Baymbix it npaKTBIIeCKBX pa60TII1KOB.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BBEJJEHHE
fojj-beM 3BepOBOJjCTpa, OXOTHWJberO XO35IbICTBa H CB5I3aHHOro
C HHM C06aKOBOjjeTBa HrpaCT KpyHHyio pO7h B OCyIIjeCTBJIeHHH 3aAa-
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ero CTaJja -- OBeu Iia Iore, OJIe1IeJI Ha CeBepe. 9peBIIHe ervIHTHHe,
Kai{ H3BCCTIIO, HOKJIOHAJIHCb co6aKe. KynbT CO6aKH OTpaxC\IbiX I, HOr,CC,I1lC11,11OM 0611X0,-IC H T90 0TyCN1bIX
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LIVMa y C06aK 11111p0K0 paCnpoCTp3Helfa B ABCTJHH. TOK, B Befie
y 24,4% am6yJlaTOpnblx H y 29,1 % O'rauI0llapnhIX 6OJIbIblX 0063K
6!,IJIa VCT3H011,1e11a oyma (Bop'r, 1908).
B Nunn 9yMa v co6aK 6bIJIa BIIepI3bIC OTMC'ICna B 1762 1'. ita
tore YKpanlloi, Ky 3 on8 6blJia ftK06b1 3311000na 113 Kpblia (Jlayp-
Coll) 11 ICpB011a1l3JlbilO na3binaJlacb KKpb1MCKOH 60JIC3111,10>%.
IIo ni00111n0 11. LIepHOx3ocT013a (1863), B POCCUIO ooyia cO6fK
6Flga 13HCpI3iie 33II000na BO BTOpoii nO.fOBHHe XVIII B. C 13BC)CII1111MH
03 AIIFJInll, Illpalliui1I, I epMa1(1111 OXOTHn'16nMH co)aliamii. B 1771) r.
'IVMa co6aK BIICpob1e OTMC'ie113 11 P11OCKBC (KpacuCKnii), 13 1848 r.-
B IIcrep6yprc (11. Po>Knc3, 1849). ,-nnCaJl
B 191 1 r. 11. I I. BOrj7110B, 33001 y1011111i-1 KJ1BllllKOH'IyMb1 CO6;1K B KHCBe.
[Jo 11. E. I1,3panJle[H'ly (1928), n3 2 000 c063K, II3XOJlnB!IIUXCM
II Kp}'!111bIX FOCV;'IapCTBennblX nnTOM11IIKax nOJL BCTepnllapilhiM IIa6JIlo-
JjCIIneM, B Te'lellne FOJla uymOH 6ojie.1o 23%. Ho B. P. 1`IJIh'I11u
CKOMy (1928), B I1O.TITa3C I13 Kax;,gi,ix 55 co6aK-naulIcuToB npuxo-
AfaOfl 10 6oJlbllbIX 9ym0ii (18%). B HH(JJeKUlOiuHOH KJlnllnKe KIie3-
C'-O1-0 l eTCpIIiIflpIloro IIICTlITyTa 6bIJl11 roJlbl, KortIa 9yMOH CTpaJIaJIC:,
80?/. 6o.nbxbix 0063K (A. KapOTH'I H Ap., 1939).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Z-IyMa MnOTOHJtHbIX pacnpoCTpaneiTa no BceMy KpaI3HeMy CeBepy,
Ha Kpa}3HeM CeBepe EBponbl, B f peHJlaHaHH, 3nH300THH 4yMbI
y co6aK 6br.na oTMegexa (DJ1eMHH}KeM (1875), FHOpTJIyHaOM (1908).
no aaHHbIM I'HopTJlyHJia, oHa oxBaTHJ}a Bce IIajiHgHOe co6agbe
HOroJioBbe, TpeTbSJ 4aCTb KoTOporo norH6Jra.
Ha ceBepe AMepHKH, B IUTaTe MHHHe30Ta, CIIIA, no aaHHbIM
SBaHCa H f'pHHa (1939), B 1934 H 1935 rr. CHJIbnax BCrIbIIUK$ IIyMbI
HMeJIa McCTO cpe,gFI aHKHX cepbrx JIHCHg. Fla ceBepe EBponefiCKOJi
4acTH POCCHH H B Cn6HpH YyMa cpeJZH co6aK cTa.Ia H3BecTHOrI
c 1783 r. (BpanreJrb, 1843), a B 1821-1822 rr., no aaHHblm BpaH-
reJFa, no peKaM KOJIbrIe, HHAnrHpKe, .lleHe H /IHe OT 4yMbI norH6Jlo
80% Bcero HOro,noBbB co6aK.
no B. Kn6epy (1824), B , H.-KoJIbIMCKe B Te4eHHe HeCKOJIbKHX
1Ie,IIeJIb OT 4yMbI norH6JIH rIOT-}TH Bee HMeBIIIHec l TaM 300 co6aK.
flo A. 11. CKa.nony (1930), . A. H. Ma30Bep (1932) coo61awi o rFI-
6eJIH OT 4yMbI 30% Bcero norojIOBbH co6aK B TypyxalICKOM Kpae. no
C. C. I.I.IaHIKOBy (1892), Ha ceBepe 5IKyTHH OT 9nH300THH 4yMbI
rnorn6:io 6ojiee 50% Co6aK, B YCTbAHCKOM paflOHe 143 600 co6aK
norn6Jro 380, B )KHraHCKOM - 1 346 co6aK - HOtTH Bee HaJIHIIHoe
norojlonbe.
no A. A. POMaHOBy (1927, 1929), oAFroli H3 npH'HH ynaaKa e3JI0-
BOro Co6aKOBOACTBa B HH30Bb5IX P. JleHb1 5IBJIHIOTCH H04TH e}KeroJjifo
CBHpenCTBOBaBnI}Ie 9FH300THH 4yMbI.
Flo A. (P. 1IHPKOBOI'1 (1941), 9FH300THH 4yMbI nJIOTOHAHbIX CpejI,Ff
JIHcHu, necuoB H ropxocTaeB oTMetena Ha SIMO,ne B 1932-1933 rr.
flo I{a1HFoM aaHHbIM (OXOTKOppecnOHJZeIlTOB BHHHKfll), Ha
FbIAaHCKOM 1lOJIyOCTpOBC B 1947 r. OTMOIIeHa MaCCOBaB rH6eJrb
co6aK OT 4yMbI.
D. H. LUepeiueBcKHii (1946) Ha6JnoAajl Fra ceBepe SIKyTHH
B 1930-1932 rr. TpH BCnbIWKH 4yMbI y Co6aK, Bbr3BaBHIHe B He6d{a-
1'OnOJIV4HbIX pafiOHaX n04TH nOrOJIOBHyfO r-6eJIb C06aK.
Ilo H. H. Pe6poBy (1939) 3[1H300TIIB 4yMbI co6aK B 1933--
1934 rr., HagaBIIIa'CH B IIeTponaBJIOBCKe-Ha-KaM4aTKe, pacnpocTpa-
IiHJlacb K ceBepy H 6bLJIa OTMe~teHa B HH}KHe-KOJIbIMCKOM, CpeAHe-
KOJIbIMCKOM, AJljiaHXOBCKOM, J' CTb'HCKOM, EyJIyHCKOM H Apyl'HX
pacon ax 1KyTHH, rue naj[21I; COOTBeTCTBeHHD COCTaBHJI 55, 60, 51,
25 }I 28% Bcero riOrOJIOBbn co6aK. DTa BnH300THn, pacnpoCTpaI1nfl^.b
C BOCTOKa Ha 3anaa no KpauneMy CeBepy Ao yCTbn p. Jleubl, pac-
rlpOCTpa}InJIaCb K IOry H BbI3B3JIa, corjlaCHO aaHFIbIM TpaBHHa (1934),
TH}KeJlVIO r3Cnbt IKy B ByJIyHCKOM pafOHe, rjle B 1931 r. OT 4yMbI
nor16JI0 OKOJIO 1 500 co6aK. MaccbBble 3a6oneBaHH51 co6aK 4yMOri
b AKyTCKOA ACCP Ha6.nioaaJIHCb HaMH B 1934-1935 rr.
B YCTbHHCKOM pafloHe B 1940-1941 rr. BHOBb HMefIa McCTO
I BHHTIW1T--BcecoI0311bIN Hay9Ho-HCCJIe, oBaTeJncKiA HHCTHTyT NCHBOTHOrO
CbIJ)LA H TIyLIIHHHbI.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BCHbIHIKa 9yMbI, H3 HMCBIIIHXCH B IIaJIHgHH 1 540 co6aK 3a6oJ1eJlo
OKOJIO 700 H 3a Ko9OTKHFi CPOK Haim 6o tee 300.
B0.I1biuaH 9H14300THH 9yMbI cpeJIH e3J oBbiX Co6aK 6b1JIa OTMe4eHa
B 1941 F. B 6VxTe THKCH.
Tp3BHII (1930) coo61ijHJi 0 TH)KeJIOH 9H11300THH 9yMbI co6aK Ha
p. L'IHJwrnpKe, a no 3. H. HIepeweBCKOMy, B pe3yJlbTaTe 3HH300THH
9yMbI co6aK Ha KOJIbIMe B 1933 r. HOr0JIOBbe co6aK COKpaTHJIOCb
Ho9TH BJBOe - c 10 400 go 5 700, iipHiICM B HeKOTOphIX paHOxax
He oCTaJlocb HII O,LHOH co6aKH.
HO HalUHM JIaHHbIM (OXOTKOppeCHOH. eHTOB BHHH)KI-I), B
1947----1948 rr. I3 AJIJIanXOBCKOM, H.-KOJIbIMCKOM H CpeaHe-Koji bIM-
CKOM pailoilax, B 1950 F. B H.-KOJIbIMCKOM H B 1951-1952 rr. B OJie-
IiCKCKOM paliollaX ~IKyTHH 6bIJIH o6Hapy}KeHbI COTH11 TpyfOB HeCH,OB,
JIiiCHU H BOJIKOB, 11oI'116HIHX, no MHeHH10 MCCTIIbIX )KHTeJIeH, OT 9yMbI;
I'H61IIi H co6aKH. MaCCOBaB rU6CJIb HeCuOB, JIIICHII, H BOJIKOB OT
'IVMb1 B 1947 r. oTnieoexa Ha 51MaJie.
3HI1300TI12 tlyMbl y CO63K oTMeBena I-Ia OCTpOBaX KOJIryeB Ii
11013311 3eMJI5i, rae exceroJjHo Hor163.Ho OT 9TON 6oJIC3HH ao 50%,
a B oTJIeJIblible r0 bi Bce Horo,noBbe co6aK (A. H. )jy6poUcKHI1, 1937) .
LIyti1a co6aK OTMle9ella B THMaHCKOH TyHJZpe (10. BacnjibeB, 1932),
a Ha Ko,nbCKOVM HoJlyocTpoBe H 60abllle3eMC.3hCKOH Ty11,Lpe owl,
Po-B11-11IMOMy, oTCyTCTByeT.
Al. Liy(11yes (1928) coo6iun.a o 1 116ei1H B 1925 r. 75 0~, co6aK Ha
OXOTCKOM Il06epC)Kbe OT 9HII300THH 9yMbI.
Ha I-IyKOTKe, Ho 3. 11. LHCpeLHCBCKOMy, Hor16.3H OT 9yMbi B 1933 r.
3 162 co6aiii It B 1931 r. 1 636 co6aK, a B AHa;iolpckoM 11 NlapxOB-
CKOM paiionax - 70% C3JIOBbix co6aK.
Ho cnHneTe,nbcTry H. THxolfeoKO (1939), Ha LlI 'KOTKe B TeteHHe
7 JILT IICCKOJibKO p03 IIMCJiH MCCTO TH)Kejible HCHb11HKH 9yMbI Co6aK,
VIHi9TO)KHBIHI1e 69-70 rcero HorOJi0Bb51. Ho 1131HI1M z anliblM,
9N Ma HJIOTOSiJIHbIX CpeJJi HCC1j013 B 1954 r. OTMC9eHa Ha o. hepuHra:
3Bepli 6O.'ie.I,I if iIOrli():u] H KfK 13 I;pHpOJjC, T0K 11 B 3BCp000BXO3C.
I11 KnM;IaTKe 9H11'MOTH H 9yMbI, 110 ,Ra11HbiM A. CJL-HAI HKOr0
(189(3), poiu aTTi1 (1897) 11 ipyrHX, HB11 iOCb 0pH9HH011 COKpOHICHIISO
XO:111 JeCTBa Co6aKK C I I ThIC. ,'j0 6,5 ThIC. 101100.
IIo C. A. Fpiollcpy (1915), 11o6poi3wiix1oMy (1927), H. KooJi-
3cTHB0HJ1y (192(,) 11 Jlp)i'IIM, e)KCFOJIHblC 9H11300TI111 9yMbI -- OJ(lia i13
OCHOi>III,IX iJpH9HII 000paJUCHHH 9I1CJ1C111iOCTH C3JjOBhiX COU3KK 110 KaM-
'IaTKe: OTXO1 OT D1, ,011 60:10,31111 B OT4CJIUI1b1C FOJjbI AOCTHI'aJI 13 Ana
gbipe 80 (() BCCFO HOr0.11OBb5.
311300TIi9eCKHe BCHbilliKH tlyMbl IlJiOTO5IJijIbiX V JIOCHIC, I10pOK.
aOTO131I,IjHb1X Co6aK, C06(,J1CH, COJ1Cp)KaBHI11XC2 I3 71013O.1C, ii003.11O-
KpaTHO OTMC9CiIbI C KOHija IIpOI1IJIOFO CTOJICTHSI B C:CC,P, CLHA,
AiIFJ11111, KairaJle, paIIHHH, TCpMannu, A13CTp3H, IJJBCIIHH, 'ua11HH,
I OJ1JIail3I3H, A,'1>KiJpe H Jipyl- lX CTpaliaX H ilCpe3JK0 BbI3biBa.iu Macco -
Byto rll6eJib 311epe3. B JlaHHH B 1953-1955 rr. 3aperHCrpHpoBaHa
11 BClibilliKa 9yMbI HJiOTOHJ.HbIX y IIOpoK. B To.n.nanJIHH B 1955 F. Ha
2 KpynHb!X (j)C MaX HOPOK OTXOJj OT 9yMbI 1IJIOTOHJIHbIX J 0CTHr 700/p.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TJIABA BTOPAX
DTHOJIOI'NA
OTHOJIorHeI3 LIyMbi H.nOTOHJjHbIX 3aHIIMaJiocb MHO1KeCTBO HccJleJjo.
BaTeJiei .
LIyMy OTO?KJjeCTBJIAJIH C KOpoBbel OCnorl, ycMaTpHBa.TIH B HeII KOB-
CTHTyujHOHaJIbHoe cTpaJjaHHe, 6o.Tie3Hh pa3BHTH51 H Jjp. Oco6oe 3Ha-
LfeHHe npHJjaBaJIH TIPOT0302M (B. A. SIKHMOB H H. KOJIb-SIKHMO-
isa, 1912, KaHTOpOBHLI H JIeBH, 1923 H gp.), reJIbMHHTaM (JTerpeH H
)Kaxo, 1890, C. F. IOJIHH, 1928 H Jjp.).
PyccKHe yLlenhfe em e B 70-x rojax XIX BeKa (E. M. 3eMMep,
A. A. KpaeBCKHI3) 3KcnepHMeHTaJIbHO BOCI1pOIJ3BeJIH LIyMy co6aK H
BnepBble B MIIpe Haygllo ,u[oKa3aJIH ee 3apa3HOCTb H BbICOKyIo KOH-
Tarn03HOCTb.
B JjaJIbHeAujeM HaCTOFIgHBO Ii3yLIaJIaCb 9THOJIOrHH 3TOro 3a6oJe-
fSaHHH, BO36yJ[HTe.TieM KOTOporO OJjHO BpeMH CgHTaJIH oco6oe 3apa3-
Hoe BeujeCTBO - Ke cepoJlOrH'IeCKH, B peOKUHH arr:IK)THHaUHn (THTp OT I: 1(1
Ao I : 800) H HMMyiiojioFWIecKll. B ero orlblTax co6ai:Tl, Ilepe6oJTer-
HIHe CnoHTaHHOr uyMOri, 6bIJIII IICBOCIIpUHMOHBbl K 3apB KCHHIO Bact.
bronchosepticus, a nepeuecnlHe 3apaxcenue 3TOI1 6aKTepneH, ripno6pe-
TaJIII HeBocnpIinMTIHBOCTb K eCTed1BeHHOH HH(jeKUHH. UaHHble o gaCTO-
Te Bb1AeJIeHI-5i Bact. bronchosepticus OT co6aK, 6oJ36xbIX HJIH naBHiHX
OT 'IyMbI, pa3H0pe'HBbI. (I)eppH BhiAeJIHJi ee B 100% CJIyoaeI3, MaK
FOBaH-B 93%, Tepper H Pae, IIIJIHHrMaFI, KoHAo-B 81 %, IiayMao
(1923)-46%, Fap.ren6epr (1926)-61%, I1acKIIrIH (19:31)-2O"""'
JIeiAJloy H JgCIIKHII-12,5%, Cioulrr H CTepcep (1952)-28,5?AQ.
HH B OAHOM CJIyITae He vlja:iOCI, BbTJ eJlnTb Bact. bronchosepticus
Kappe (1914), Kaplroiiy (1939), Ila3apooy, aBTOpy C coTpyAHIIKaMF
H Ap.
HpOTHB 3THO.1TOrn'IeCKoro 311a,ieiIHH Bact. bronchosepticus BhTCTV-
nH.n Kappe (1914). OH nOKa3aJI, LITO Co6aKH, 3KCIIepuMeHTaJIbH0 3a-
pa>KCUhlbIC Bact. bronchosepticus, rre 3apa3TThI AJ15T KOHTaKTHpyIOHjHX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
c HHMH 3JjOpOBbIX co6aK. HO Kappe (1930), Bact. bronchosepticus.
HrpaeT pOJIb TOJIbKO BTOpHLIHOro BO36ygHTeJISI COHYTCTBYIOIAHX HJIII
OCJIO)KHH1OU HX 4yMy HaTOJIOrH4eCKHX npoueCCOB.
3THOJIOFH4eCKyK) poJlb Bact. bronchosepticus oTpHuaJla TaK)Ke
aHrJIH11CKaH KOMHCCHA no 6opb6e c 4yMO1i y co6aK.
,aaHHble o Bact. bronchoseptiCUS KaK o CnerHq)HYeCKOM BO36yJ(H-
TeJte 4yMbI y co6aK 6bIJIH 9KCnepHMeHTaJlbHO OnpOBeprHyTbI B. B. KO-
HIeBbIM (1928). B pa3rap 9nH300THH 6bIJI0 HCCJIeJZOBaHO 109
HgeHKOB, 60JIbHbIX 4yMOIi. floceBbI H3 KpOBH, 6pOHXHaJlbHOrO ceKpeTa
H BHYTpeHHHX opraHOB OT 80 njeHKOB, CJgeJIaHHble B nepBble JgHH 60-
JIe3HH, 6bIJIH CTepHJIbHbI 30 JjHeI{, ByJIbOHHacI KyJibTypa Bact.
bronchosepticus, BbIJgeJIeHHacj KOHIeBbIM H3 HOCOBOI3 CJIH3H 6OJIbHbIX
4yMOFi co6aK, npH nO,I;KO}KHOI3 Cy6HHOKyJIHIgHH He BbI3BaJIa y HgeHKO.i
4yMy. IIpH BBe)geHHH )Ke ee B JgbIXaTe.nbHble nyTH HgeHKH 3a6oJIeJIH H
Ha 6-8 JgeHb naJIH. aBe co6aKH, nepe6ojleBHIHe 4yMoii H rnnepnMMy
HH3HpOBaHHble, 3a60Jie.IH nocj(e HHTpaBeH03HorO BBeJgeHHSI 0,1 MJI
6YJIbOHH01i KyJIbTypbl Bact. bronchosepticus. Bce CHMHTOMbI Hano-
MHHaJIH 4yMy. Koweao npHHIeJI K 3aKJIK)4eHHI0, TO Bact. broncho-
septicus MO)KeT BbI3bIBaTb Ca MOCTOHTeJIbHOe, 06oCo6JIeHHoe OT 4yMbI
3a60JIeBaHHe y co6aK, a paBHO COnpOBO)KJgaTb H OCJIO)KHHTb 4yMy
co6aK.
B Onb1TaX Byjga (1929) co6aKH, HMMYHHbie K BHpyCy 4yMbI, 3apa-
)KaJIHCb Bact. bronchosepticus.
P. A. UHOH (1948) OTBOJ[HT 9TOI3 6aKTepHH pOJIb B036y.z HTejISI
caMOCTOHTejIbHOH H03OJIorjigeCKofI eAHHHubI - 9HTepHTa co6aK.
Ha3a;pOBbIM B 2,8% nccJIeJjOBaHHI3. 6bIJIa BbIJgeJleHa Bact. fecalis,
alcaligenes, 6JIH3KaH K Bact. bronchosepticus, xOTOpax, cor.nacxo
BepJg)KH (1948) , Bcerz a HaXOJjHTCSH B KHIHe4HHKe H 06bI4HO C4HTaeTC51
HeraTOreHH01i. OHbITbI 3apa)KeHHSI ero LueHKOB B OTJgeJIbHbIX cJIy4aHx
BbI3bIBaJiH 3a60JIeBaHHe C npH3HaKaMH 4yMbI. 11eM KyJlbTypa 6b1Jla
MOJIO)Ke H 4eM McHbnle oHa nepeceBajlaCb, TeM nepe6oJleBaHHe 6bIJIO
6oJiee T$DKe.IbIM H HPOJ[OJI)KHTeJIbHbIM. 140 MHeHIH0 Ha3apoBa, TO
o6'bHCHHeTCSI HJIH (JeHOMeHOM aJIJ1o6HO(popHH, npH KOTOpOM KOJIH4e-
CTBO BHpyca 4yMbI HO Mepe nepeceBOB yMeHbinaeTCH, HJIH nOTepeii
6aKTepHe11 BHpYJIeHTHOCTH npH nepeceBax H xpaaeHHH.
Ho H'aHIHM gaHHbIM, JjO6bITbIM COBMeCTHO C M. T. 51BOpCKOii, npH
6aKTepHo.lorH4ecKOM Hcc.neJ[OBaHHH HeCKOJIbKHX COT TpynoB co6aic,
naBIIIHX OT 4yMbI, B 1 1 CJIyLaHX yJgaJIOCb BbIJgeJIHTb Bact. fecalis alca-
llgenes. B Ham ux OnbITBX q)HJIbTpaT 6yJIbOHHOIi KyJIbTypbI 9TOIf 6aK-
TepHH Bbl313IBaJI y HgeHKOB iyMOno, o6HOe 3a6oJIeBaHHe.
POJIb CTPEIITOKOKKOB
.TIHHbep 00061uHJI, 4TO HPH HepBHOli (j)OPMe 4yMbI H3 CHHHHOPO:
H roJIOBHoro M03ra co6aK B 6oJIbIIIOM KOJIH4eCTBe BbIJgeJIAK)TCA cIperl-
TOKOKKH, B TO BpeMB KaK KpOBb H Bce napeHXHMaT03Hble OpraHbI OCTa-
IOTCH 6aKTepHOJIOrH4eCKH CTepHJIbHbIMH. Coo6meHHH 0 BbIJgeJIeHHn
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
crpenToKOKKOB CJeJ1ajin TaK)Ke Hycxar H LLITeKep (1930), BeMeJlb-
MaH (1930), H. Upem5IUKHK H H. Pa3yMOBCIKe 06paTHJI BHHMaHHe Ha TO, 'ITO npH HepBHO1H (i)OP-
Me'IyMbl H3 O'IaFOB nopa}KeHH5I-rOJ1OBHOro Moira 60JIbHbIX co6aK He-
peAKO yaaeTCfl Bb1JZeJIHTb BHpyJICHTHble CTpenTOKOKKH. JIOKXapT
(1930) HCnOJIb3oBaJI Ha6JFIOJeHF1e KolueBOro H BbICTynHJI c coo6we-
HHeM 0 TOM, 'ITO Bb1AeJieHHblH HM H3 >KeJ1yJ1O'IKOB roJIOBHOrO M03ra H
CnHIIHOMO3rOBOFi >KHJIKOCTH co6aK, 60JIbHbIX 'IyM01l, Streptococcus
cerebris canis flBJIHeTCSI cneuH(IH'IeCKHM B036yAHTeJ1eM HepBHblX
npoaB.ne114N 3TOcI 6o.le3HH. LIpH HHOKyJIfluHH KyJIbTy'pbl 3TOrO MHK-
po6a IIIeHKaM, HMMyHHbIM K'I Me, B03HHKajm a6cueccbl, HO 6e3 HepB-
HbIX CHMnTOMOB. OAHaKO H'epBHble npOBBJIeHHB OTMe'IEHbI B 800/p
CJly'IaeB, KorJa KyJIbTy'pbI 9TOr0 CTp'eHTOKOKKa HHOKyJIHpOBaJlHcb
B iiepuOA rlepBOrO TCMnepaTypHOrO noJl"beMa, BbI3BaHHOrO BHpyCOM
'IyMbl. 17O-BHAHMOMy, 9T0 06"b1CHleTCH TeM, 'ITO BHpyC 9yMbI KaK 6b1
n0'IBy JJIn pa3BHTHH 6aKTepHaJlbHOI.i HI1(1)eKLHH B L eH-
TpaJIbHO11 HepBHOH CHCTeMe.
Ha3apoB HHTpaTpaxeaJlbHbIM BBeAelIHeM KyJIbTypbl CTpeIITOKOKKa
Bb13BaJI y co6aKH 'IyMonoJ oOHbie HepBHble HBJ1eHHB.
Coo6HIeHHe U. A. MaHTe11(~eJlfl (1934) 0 B03MO>KHO11 3THOJlorHie-
CKOcI pOJ1H CTpenTOKOKKa B 9YMOHOJ06HOM 3a6OJleBaHHH co60Jieii,
COnpOBOHCAaBIIIeMCfl HepBHbIMH npanaAKaMH, He HaulJlo nOJITBep>KAe-
HHfl B pa6oTe Hauuell COTpyAHHubI C. E. CopHHOI3 (1953). CTpenTO-
KOKKH, BblL eJIeuHble BO BpCMH 6OJIbLuou BCnbIWKH 'IyMbl CpeAH co6o-
Jlei H3 napeHXHMaTO3HbIX opraHOB H M03ra naBI111IX 3BepbKOB, 6bIJIH
HenaToreuHbl. Y JIHCHU, npH He6JlaronpHHTHbIX yCJIOBHHX coj ep>Ka-
f)Hfl, CTpeHTOKOKKH 11epe)lKO BbI3blBaK)T TIDKe.lble ()opMbl CTpenTOKOK-
1KHe Ha iyMy.
POJIb IIACTEPEJIJI
JIHHbep (1906), 3axBaIi (1911),HacTOBbIAeJISBLHHeBact. bipolaris
septicus (Pesteurella canis) OT 'IyMHbIX co6aK, C IHTaJIH ee cue-
uH(f)H'IeCKHM B036yAl4TeJIeM '1_yMbl, TaK KaK OHa Bbl3bIBa.na CHMI1TOMbI
H OCJIO}KHeHUSI, noxo He Ha uyMy y co6aK. IIITpaycc 143 pTa H 3eBa
21 3AOpOBOHF co6aKH B 3 c.ny'Iaflx Bb1AeJIHJ1 6HrloJlflpnble naJIO'1KH,
KoTOpble OTHCC K rpynne canpo(JHTHpyIOLUHx naCTepeJlJl.
Kowe3oMy yJla.IOCb BbIJICJIHTb naCTepe.nJly TOJIbKO B OAHOM CJPy-
'Iae H3 109. BbIJjeJI1JI naCTepeJIJI OT IyMHbIX co6aK BeJIbC (1949). Flpa
cneuHaJlbhIbIX MHOr09HCJ1eHHbIX nolCKaX y 'IyMHbIX co6aK HH pa3y'
He yJlaJTOCb o6Hapy>I{HTb naCTepeJIJI flaCKHHH, KapHOHy, Ha3apOBy,
aBTOpy H ero COTpyJHIIKaM H Ap. B nOCJIe. Hee BpeMH naCTepeJI.na BbI-
j eJieHa HaMH OT JIHCHu? LIaCTepeJUIe3 y co6aK H JIHCHU. 1BJISIeTCA
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
caMOCTOHTejIbHOIi H030JIOrJ4eCKOH e,11HHHueI3 H, 11O-BH,4HMOMy, y
co6aK OH pe}Ke, 4eM y JIHCHu, COHyTCTByeT HJIH OCJIO)KHHeT 4yMy
HJI OTOH,gHbIX.
POJIb CAJIbMOHEJIJI
OT CO6aK H JIHCHu, 6OJIbHbIX HJIH HaBIJIHX OT LIyMbI HJIOTOHJ);HbIX,
TIHOFHMH HccJIeAOBaTeJIHMH Hepe;IKO BbIJ1eogimeb 6aKTepH4 H3 KO.TITI-
nIqJo3HOI3 rpynrIbI (JIH11bep; BplorreMaH; JIOKKapT; Bap,geH6epr,
1926; KouteBOH; Kapiol; BepxKe, 1944; CMIIT H . pyrme, 1950; BHAb-
HMC H RpyrHe, 1950; AJ1Jiep H upyriie, 1951; Ha3apoB). HeKOTOpble
aBTOpbI OJ1HO BpeMH OHIH604HO C4HTaJIH CaJIbMOHeJIJI B036y,gHTe.,IH of
LIyMbi HJIOTOHJ1HbIX y co6aK (ByHulreiH, 1906, 1913), y JIIicnu (FpHH,
1926). B Hauler Jla6opaTOpHH OT co6aK H JIHCHu, 6OJIbHblX 4yMOfI,
HepeJIKO Bbl, ejlHJlHCb Bact. coli comm., pa3JIH4Hble ca.nbMolle.rJlbi.
OHH OCJIO}KHHIOT 11 OTHro[I aIoT Te4eii e 4yMb1 H HepeJLKO HMe[OT ca:.Io-
CTOHTeJIbHoe 3THOJIOrH4eCKoe 3Ha'eHHe, BbI3b1Ba i, OcO6eHHO Y Luelr-
KOB, KOJHT6auHJ1Jie3 H HapaTHc), KJIHHH4ecKH HOXOiKHe Ha 4VMy-.
(epp1 (1906) IlepBbrf yCTaHOBHJI, WO CTa(JHJIOKOKKii II Oco6eHHO
4aCTO BbIaeJIHCMbIti Staphylococcus pyog. albus HpHBOJIHT K CTa(PH-
JIOKOKKOBOfi ceHTHueMHH H rH6ejiH CO6aK, 60JIbHbIX 4yMOli.
Ha Cepbe3Hoe 3HaLieHHe BTOpu4H013 CTa()HJIOKOKKOBoI HH(JeKuHH,
KaK OCA0A{He1111H 4~'Mb1 y co6aK, yKa3aJI TaK1Ke JJa(jpaHUle (1911).
HanpOTIIB, BayMaH, JIOKXapT, JIeilJijioy H AeHKHH, , peMHUKHA H
Pa3yMOBCKIJf, IIIAHHFMaH, CyHHr H CTepcep, fIaCKOHH, KapHOH, Ha.
3apoB, Benbc (1949) H J1pyrHe aBTOpbI, BbIAeJIHBwHe 6e:ii Ff CTa(pHAO-
KOKK, He ripH,gaBaJIH eMy oco6orO 3HageHHH.
HO IIaWHHM Tjal-IHblM, CTa(1)HJIOKOKKH BbIaeJIAK)TCH y 4yMHbIX ?KHBOT-
IIbIX H Cepbe3HO Oc.noA{HHIOT Te4CHIIe 60JIe3HH.
B HaCTO51mee B9CMH B CBeTe HeKOTOpbIX pa60T, rJIaB11bIM o6pa3oul
F. B. BbIro,ROHKOBa (1950), CTaJIO HCHO, 4TO epeJH CTaOHjIoKOKKOB,
B TOM 4uc ie H 6eJIbIX, HMeeTCH 60Abuloe KO.THOCCTBO TOKC11KOrem1bl
11ITaMMOB. lloCJIeJHIie BbI3bIB IIOT V HOJIOHbITHbIX AKHBOTFIb1X HHH1eBbIC
of paBJICHHH, fCMOAHTIl4CCKHe, aepMolleKpOTH ieCKHe H ACTajIbHble fB-
JICHHH. HOKa3aFIO TaK)Ke pacnpocrpaHeHlle 11HOKOKKOBOH (lAOpbI B03-
)yuIHO-KaHeJIbHbIM H B03J1yIIIFIbIM CHOcO6aMH (C. C. PCq ieiiCK1IiI,
1944), 2110CHTeJmCTBo> HaTOreIIHbIX CTacpHJIOKOKKOB B IIOCOFJIOTKe,
IIX CBH3b CO CTa(lIiAOKOKKaMH, HaXOJjHWHMHCH Ha TeJIe (MaiJIe H
;~pyrHe, 1944). Bo3HIIKaeT BOHpOC: He OT HHX Jill 3aBIICHT 3THOreue3
FHOHHbIX puHHTOB, KOII'bJOIIKTHBHTOB H HyCTyJIe3HCN 3K33HTCMbi
V 4yMHbIX co6aK.
B3rJI51J1 Ha 6e3o6HIHOCTb CTacI)HAOKOKKOB, Oc06CHHO 6eJIbIX, Bbi-
J1eJIeuHbIX OT Co6aK, 6o,nb1Ibix 'IyMO i, Fiy>KJjaeTCH B HepeCMOTpe.
2. E. C. 4cpcaccHHrt 17
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
K LIHcJIy 6aKTepHI3-CnyTIIHKOB YyMbi rIJIOTO11LHbIX OTHOC51TC51 TaK-
)Ke pa3JIHNHble CnHpOXeTbI (FOJIbTop6aX, 1912), CTpeBTO6aIHJIJIb1
(MauyKKH, 1921), Bact. coli comm., Bact.liguifaciens, Bact. proteus
vulg., Bact. fluorescens, Bact. pyocyaneus, Bact. mesenterius, Bact.
subtllis H Ap. (HaCKHHH, l.IlTpayc, KOIHeBOli, Ha3apoB, C06CTBeHHble
HCCJIeAOBaHHSI H AP.).
HpH 6aKTepHOJIorHLIeCKOM HCCJIeAOBaHHH KpOBH, B39TOR H3 CepA-
ua 312 LueHKOB, 3KCIIepHMCHTaJIbHO 3apa}KeHHbIX LIyMOII, B 87% noce-
Bbl OCTaJIHcb CTepHJIbHbIMH. B 92 %p noceBOB H3 461 Tpyna co6aK, naB-
IHHX OT LIyMbI, 6b1JIH BbIAeJIeHbI yKa32HHble BbIIIIe MHKpoopraHH3Mhr.
3TH JjaHHble, fOJIy'IeHHble B Hawweii JIa6opaTOpHH, COOTBeTCTByIOT pe-
3yJIbTaTaM HCCJIeAOBaIIHfl FBHHApHXOM (1950) 120 co6aK, y611TbIX B
nepBble 10 AHeII noc.ne 3apa}KeHH51. OHH nOKa3aJIH, TITO 86% 6aKTe-
pHOJIorHLIeCKH FICCJIeAOBaHHbIX opraHOB-CTepHJIbHbI. H3 OCTaJIbHbIX
6b1JIH BbIJIEJIeHbI caJIbMOHeJIJIbI, CTac!HJIOKOKKH, CTpe1ITOKOKKII H Apy-
raft MHKpO(4JIOpa.
AHajin3 npHBeJjeHHblX JJaHHbIX YKa3bIBaeT Ha HaH6OJIbIIIyIO BbIAC
JISIeMOCTb pa3JIHLIHbIX 6aKTepHFI y TpynOB. HepeJ Ko 6aKTepHH OTCyT-
CTBy1OT B OCTpOII CTaAHH 6oJIe3HH H nOHBJISIIOTCII TOJIbKO noc.ne rH6e-
JIH )KHBOTHbIX. (DaKT CpaBHHTeJIbHO pejjKOrO BbIAe.IeHHH Bact. bron-
chosepticus H Bact. faecalis alcaligenes He noATBep}KJjaeT Hx oco
6old POJIH B 3THOJIOrHH qyMbI fJIOTOHJIHbIX.
B HTOre HaIrlHX Ha6JIIOAeHHI3 MbI npHIIIJIH K BbIBOAy, LITO IIpH LIyMe
rIJIOTOSIAHhIX Ba}KHyIO pOJIb HrpaIOT yCJIOBHO-naTOreHHble 6aKTepml,
KaK OCJIO}KHHIoluHe 3a6oJIeBaHHe, H LITO 3TO AOJI}KHO CTpOrO yqHTb:-
BaTbCSI npH npOCl)HJIaKTHKe H JIeL1eHIIH 3TOH 60JIe3HH.
B CBeTe COBpeMeHHbIX JjaHHbIX o6 H3MeHLIHBOCTH MHKpO6O!.
(A. A. HMuielleuKHH, 1952, C. H. MypoMueB, 1953), B iaCTHOCTH KO-
JIHTHq)03HOII rpynnbl (B. ~J. THMaKOB, 1952, (P. F. FpHH6ayM, 1952,
F. Fl. KaJIHxa, 1950, 1952 H AP.), BOnpOC 0 relle3e H POJIH CoIIyTCT-
ByIOHjHX H OCJIO}KHSIIOUJHX 4yMy y co6aK TaK Ha3blBaeMbIX BTOpHLIHIJ
HH4)eKUHH HaAO TaK}KCe H3yLIHTb c n03HUIIH H3MeHLIHBOCTH. Ba}KHO yCTa-
IIOBHTb cJleJ(ylomee: He B03H14KaIOT JIH y co6aK, oco6eHHo y McHKOB,
KOJIH6auuHJle3, napaTHCf H HeKOTOpble apyrle HH(jJeKlHH 3H,7JOreHHO,
HyTeM nepexo a eCTeCTBeHHO o6HTaIOII eH B HX KHHIe'IHHKe KHmetlHOII
IIZJIOLIKH B naTOreHHyiO (~opMy? He HMeeli JIH Mb! 'iaCTO AeJIO C SIB-
JIeHHSIMII 3TOrO nOp5IJJKa, B03HHKaiomHMH COBepmeimo He3aBHCHMO OT
LIyMb1? H B KaKHX CJIyLIaiiX H nOLIeMy BHpyC LIyMbI cnOcO6CTByeT B03-
HHKHOBeHI1O HJIH nOBbIIIIeHH1O BH;pyJTeHTHOCTH 06bl'IHOII MHKpOC~JIOpbI
opraHH3Ma? JIIO60II BbIBOJj, CAeJIaHHbIIl TOJIbKO Ha OCHOBaHHH yMO-
3pHTCJIbHbIX 3aKJIK)LIeHHII, aHaJIOrHH C 9KCnepHMeHTaJIbHbIMH AaIIHbI-
MH UHTFIpOBaHHbIX aBTOpOB, 6hIJI 6bI HenpaBHJIeH. HpH TpaKTOBKe
nonpOca o McCTe H pOJIH 6aKTepHHHOro (flaKTOpa npH LIyMe HJIOTOSiA-
HbIX JIoJI}KHa y'HTbIBaTbCSI BO3MO}KHOCTb 3uaorexlloro npOHCXO}KJIe-
IIII51 TeX HJIH HIIbiX OCJIO]KHeHHIH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
K 3THOJIOr}H 9YMHbIX 3HIjE4bAJIOMHEJIHTOB
i-lyMa y c06aK HHOrJja npoTexaeT KaK McHHHro3HuecpaJIHT, npHqe,,I
3THOJ1orH9eCKa5i pOJIb H'eKOTOpbIMH HCCJIe,IjOBaTeJIHMH (Hepapo m
Ha(p, 1930, OKJIex, 1944) npHnHCb-BaeTCH cf HJIbTpy1omeMyCH BHpyCy,
OTJIHYHOMy OT BHpyca LIyMb! HAOTO51AHbIX.
HO OKJIeIO, B OpraHH3Me Ka}KJ[OI-I co6aKH BcerAa HMeeTC5l B JIa-
TeHTHOM COCT05IHHH KaKOFI-To BHpyC, aKTHBH3Hpyio1IJnc1cH fO BJIH-
IIHHeM BHpyca '-IyMbI nJIOTO U HbIX H Bb13bIBaiomHT3 uepe6pocnHHaJIb-
HbII3 CHHJ[pOM. Ho OKJTeio, 3TOT BHpyC JIerKO HefTpaJIH3yeTC51 cneuitgm
gecKHMH aHTHTeJIaMH, KOTOpble B 6OJIbIIIOM KOJIHgeCTBe coJjep}KaTC51
B CbIBOpOTKe B3pOCJIbIX }KHBOTHbIX.
MCTOKH 3THX MaJIoo6OCHOBaHHbIX B3FJI51AOB OKJIeH Jie)KaT B TeO-
pHH BOf3KOTTa, yTBep}KJjaBHlero, LITO BHpyCbI He npHXOJjRT H3BHe, a
caMOCTOSTTeJIbHO B03IIIIKaIOT 13 3)JOpOBOM opraHH3Me 6e3 npegHleCT-
BeHHHKOB.
3THOJIOf HR 4YMbI IIJIOTOSI,fHbIX Y HEKOTOPbIX BHLOB
17YIIIHbIX 3BEPEFI
K 3THOJ1orHH YYM61 Y JIHCH[[
BnepBble 'yMy y JIBCnu Ha6JIHOAaJ1 rpHH, Bbl)jeJIHBIIIHf4 OT 60JIb-
HbIX H naBHIHX 3Bepe13 MHKp06 H3 rpynnbl caJIbMOHeJIJI. BBeI[eHHe
BTOI'O MHKpO6a JIHCHuaM, a TaK}Ke co6aKaM BbI3bIBaJIo Y HHX HHc eK-
IIHOHHOe qyMorioao Hoe 3a60JIeBaHHe. 3TO 06CTO5ITeJIbCTBO HPHBeJIO
rpHHa K OHIH6o4HOMy BbIBo,T y o6 3THOJIOrHqeCKOf3 poJIH CaJIbMOHeJIJIbI
npH tlyMe JIHCHu H co6aK. rapJ[eH6epr yKa3aJI Ha OIHH6OUHOCTb Toro
BbIBOAa, a TaK)Ke Ha pe3KHe pa3JIHYHSI B KJIHHHgeCKOFI H naTOJIOI'O-
aHaTOMHgeCKOI3 KapTHHe qYMbI y Co6aK H '-IyMbI y JInCHu.
B TpHAuaTbIX roJ1;ax rpHHy H ero COTpygHHKaM npH MBCCOBOM
3a6oJIeBaHHH JIHCHu, HanoMHHaIOHjeM HepBHyIo (popMy 9yMbI y cO6aK,
y,uaJIOCb BbiAeJIHTb 4 HJIH 5 IHTBMMOB cneuHCpH'.IeCKHX BHpyCOB, KOTO-
pble BbI3bIBaJIH CygOpO}KHble 5IBJIeHHH. OAHOMY H3 3THX CneuHTpHge-
CKHX BHpyCOB rpHH npHnHCaJI yH'HBepcaJlbHylO CBOCO6HOCTb Bbl3bI-
BBTb 3a60JIeBaHHe 'IyMOcf Y JIHCHL, co6aK, BOJIKOB, eHOTOB, HOOK H
JIacoK. BHpycHax npHpOAa TIYMb1 Y JIHCHIU 3aTeM 6bIJIa nOATBep}KJjeHa
MHOrHMH aBTOpaMH.
T. 5q. BaHHOBCKHH (1941), H3ygaBmHI3 gyMy y pa3HbIX BHAOP
nyIIIHbIX 3Bepeli H BnepBble B CCCP onHCaBIHHf3 ee y cepe6pHCTO-qep-
HbIX JIHCHIj, yCTaHOBHJI, LITO AeIfCTBHTeJIbHbIM BO36yJJHTeJIeM TIyMbI
cepe6pHCTO-'epHbIX JIHCHIX 51BJIHeTC51 (~HJIbTpyIOIHHf3C5I BHpyC, KOTO-
pbII3 McHee naToreHeH AJI51 KpacHblx JIHCHu H Aim HjeHKOB co6aK. BaK-
TepHH-CnyTHHKH: CaJIbMOHeJIJIbI, CTpenTOKOKKH, KHIIIe'IHaTT naJIO'Ka
H ApyrHe BcTpetIaJIHCb cpaBHHTeJIbHO peaxo. HaH6OJIee TIaCTO npH
nopa}KeHHH nerKHx BaHHOBCKHrI BbIAeaISIJI reMOJIHTHgeCKHT3 CTpCCITO-
KOKK, naTOreHHbI13 AJI51 JIHCHIZ. O,TLHaKO, no AaHHbIM aBTOpa, CTpeHTO-
KOKK He HBJIHQTCH npHYHHOI3 nHeBMOHHIl y JIHCHL. HpH 6aKTepHOJIO-
FligecxoM HcCJIegOBaHHH 172 TpynOB JIHCHIU B 16 CJIy'iacix (9,3%)
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BbueJIeH crpeH'roKOKK, B 15 C.JI\ a ix (8,7%)--Cae1bMOHeJIJIbI, B 24
cJlvganx (13,9%)-KHwe4[Ian na io4Ka, B 16 cJry4a ix (9,81 (1/o )--npo-
Tei11 H jp. Ho4TH 100 TpynoB 6bIJIn 6aKTepHOJIOFii4ecKH cTepHJ1bH1-I.
K 3THOJIOrMH 9yMbt y eHOTOBHp,HbIX co6aK
(yCCyPHNCKHX eHOTOB)
B. E. HBaHOB (1930), H3y4aBLIiM 13HH300THIO tIYMbI y CHOTOBHJ`1-
I-[bIX co6aK Ha Z[a7biicm BOCTOKC, oiun6otiH0 npeJ rIOJIO)KHJI, 4TO B03-
OX' uITeJIeM 3TOFI 60JIe3H1l HBJI51IOTC51 MHKpOKOKKII, BbIJjeJICIIIIble HM 113
cepaua, JICI'KHX 11 KHI11C'HIIIKa 6OJIblIIIX Abl3hi00CrCH BI19YCOM 'IyisTbl, 'JTaIITIIpOBaBiu1iMcSi
K )TONP BIIJl,y 3Bep6i.
3T1IOJIO1NH SlyMbl Y CO5a, C!1
BilpyCiBl3 3TBOJICr11S1 'IyMLI `,' co6ojlcH BilepBble yCTa!IOBJIC1Ia
C. F. i"r)plilloil (1955). P ' 1 [c (11lllbli1 1 ('I) B1119VC 66UI fl,I t TII~I`HIIHp~
,'ill II9H y4aCTli11 or p,l KStli C060JIHIIoIII ilapHaliT BHpyCH 4yMbI
I I, IOTOSIJjIIblX.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MOP,eHHe ee Ha XA B AO3e 2,5 Mr B I PKD yMeHbuIaeT B 2,5 pa3a rH6eJIb
PK9 OT BHpyCa ~-IyMbI fJIOTOSIJIHbIX.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OTpHgaTeJIbHO BJIHSHOT Ha pa3MHo)KeHHe BFIpyCa ,L HHHTpO(fJeHOJf,
'MaJIOHOBaH KHCJIOTa H HeKOTOpble aKpHJIHHbl: pHBaHOJI H HHTpOaK-
pII,IjHH.
IIpH HHOKyJIHgHH npenapaTa B )KeJITOK, a BHpyca Ha xopnoaJi-
JIaHTOHC HaH60JIee tleTKO BbIpaM eHHbIM HHrH6HTOpHbIM J(eIICTBHeM
o6JlaJiaJOT r.mIoTaMHHOBan KHCJIOTa, aMHHOHTepHII H dl-HOpJIei3uHH,
COKpanjaJonJHe rH6eJIb PKD no CpaBHeHHIO C KOHTpOJICM COOTBeT-
CTBeHHO B 3',1, 2,5 H 2,4 pa3a.
HecomlHeHHO, TOpM0351T pa3MH0}KeHHe BHpyca, yMeHbIIIan rlI6eJib
PKD: B 1,7 pa3a a- AHHHTpoq)exo.i, 6eII3aJib,aerHRTHOCeMHKap6aao:i,
HaraHOJl, B 1,5 pa3a - pHBaIIOJI H (lypauHH H, HaKOHeg, B 1,4 pa3a-
flHTpoaxpH,IjHH H MaJIOHOBaH KHCJIOTa.
Heo6xojijnio no,a4epKHyTb,'ITO pe3yJIbTaTtI, noJly4eHHbie IIpH HHO-
KyJIHLHH B }KeJITOK, HaH60JIee gOCTOBepHbI, TaK KaK HCKJIIO'IaIOT He-
nocpeJjCTBeHHoe B3aHMOJjeIicTBHe BHpyca C HHrH6HTOipOM, 4TO HMeeT
McCTO HpH XOpHoaJIJIaHTOHCHOI3 HHOKyJIHUHH.
O,jHaKO OT OnblTa K OHbITy OTMe'eH ,1 OBOJIbHO 60JIbHIOI3 J[Hana3OH
[conIe6aHHf 3(~(peKTIIBHOCTH HHrH6HTOpOB.
Ko.,'Ie6aHHH 9TH 06yCJIoBJleHbI (JH3HOJIOrmeCKHMH 0006eHHOCTSIMH
OTJJ;eJIbHbIX napTHi=i P1 3, HX pa3HOIi 'IYBCTBHTeJibHOCTH K BHpyCy H
HHPH6HTOpy. OHII TaK?Ke BbI3bIBaioTC5I HJIOXO nOJJJjaIOHJHMIICSI KOHT-
pOJIio pa3JIH4HHMH B HHBa3HOHHbIX CBOFICTBaX BHpyca B PKD, BO
BpeMeHH H OC06eHHO no McCTY er0 BCTpetIH C HHFH6HTOpOM. HaKOHeg,
3Ha'-IHTeJIbHyIO pOJIb HrpaIOT yCJIOBIISI HPOHHKHOBeHHSI HHrH6HTOpa
BHYTpb TeX KJICTOK PKD, r,ge yxce ycneJi HatlaTbcH Hpogecc pa3MHO-
1KeHHSf BHpyca. He HCKJIIOtIeHO, tITO KOJIe6aHHH 3(IJq)eKTHBHOCTH
HHrH611TOpOB OT OnbITa K OHbITy B 3HatIHTeJIbHoI Mepe Taxxce o6-
ycJIOBJIeHbI TeM, 'TO UH4)pbI cMepTHOCTH o6,be,uHH5I10T KaK cMepTHOCTb
OT BHpyca, TaK H CMCpTIIOCTb OT BemecTBa.
3CIq)eKT no,gaBJIeHHSI, OKa3bIBaeMbII3 HOpJIeI3unHOM H rJIIOTaMH-
I-IOBOf3 KHCJIOTOII, J{OBOJIbHO BHyWHTeJIeH, a KOJIe6aHHSI 34X1JeKTHBHO-
CTH He3HagHTeJIbHbI. DTO JIaeT OCHOBaHHe OTHCCTH 3TH aMHHOKHC?
JIOTMI, 0006eHHo rJIK)TaMHHOByIO, K IIO,T JIHHHbIM HHrH6HTopaM BHpyca
tlyMbI HJIOTOSIJZHbIX var. cants.
14HrH6HT0pHoe JjeICTBHe rJIK)TaMHHOBoI3 KHCJIOTbI OTMe'IeHO JjaiKe
B cJly'aHX rH6eJIH PK9, HHOKyJIHpOBaHHbIX ei0 H BHpyCOM. Pe3yJIb-
TaTbI J(Ba}KJIbI HpOBe4eHHOrO THTpOBaHHSI B PK3 BHpyca, BbigeJIeHHO-
rO H3 CTepHJibHO HOrH61IIHX OnbITHbIX PK3, fOKa3aJIH, 'ITO rH6eJIb
PKD B OHbITe HaCTynajla 3Ha4HTeJIbHO n03,RHee, tieM B KOHTp0JIe
(II03}Ke Ha 72-96 tIac.), H 4TO BHpyC 'IyMbI, BbrJf,eJieHHbII3 H3 riaB-
LUHX PK3, HMeJI THTP 10-3 T. e. 6bIJI B 100 000 pa3 cjia6ee, tieM
B KOHTpoJle.
He OTHOCHTCH K 'HCJIy aKTHBHbIX HHPH6HTOpOB COeAHHeHHSI, JZalO-
LgHe 6oJIbllHe KOJIe6aHHSI 3(I(feKTHBHOCTH, HanpHMep MaJIOHOBaH
KHCJIOTa, XOTSI 9gX!JeKT nogaBJIeHIISI y Hee HHorAa 6bIJI paBeH 100%.
CHIOKeHHe THTpa BHpyca B naBLHHX 3M6pHOHaX BnoJIHe 3aKOHO-
MepHO yKa3blBaeT, 'ITO HeKOTOpbie npenapaTbl, XOTSI H He cnoco6Hbie
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B JOCTaTO111iOii CTeneHii no;I,aBHTb BHpyC, TeM He Mellee B 113BeCTHOI1
MCPC TOpMO351T el-0 p23MIIOiKCIIHe H 3Ha'rHTeJIb1IO 33MCjJI3IOT CpOK.
rH6eJIH PK3.
3KCnepI I MCIITa3bIIbTC Jja1Illble 0 Bblpa}KCIIIIOM Iiuru6Hpy1oL1w.%r
,_ICHCruHH r.?HOTaMII1rOBOH KIICJIOTbI, IIOpJICHUHna, aMH110HTepima Ha
B111) VC 'IVMbI FIJI OTOSIJL11bIX COBHaaaIOT C JjaHIIh1MH MIIOI'HX 1BTOPOB
O 1OJ'LOB.3C1I11H 3THMH npenapa'raMH BHIYCOB ]KCJ1TYXH IneJ]KOnpHia,
31IUe(TJaJ1oMHeJIHTa MbIHICI3, BaKuFInbi, rpnHlia H Jjp. 0i m cBHJjeTeJib-
CTByIOT 0 TONI, IT0 BIIepBble HOKa3alhHbli3 PbDKKOBbIM IM MOJJCJIH BH?
pyca Ta6agiioi1 M03a1KH (Jel-roMeH noj aBJieIIH.'I CFO pa3MHO)KCHHS(
aMIIIIOKHCJIOTaMH H aH3JI0rOM (I)OJIIICBOA KHCJIOTbI HMeeT o6Hjee BHpy-
COJIOI'H'ICCKOe 3HaoeHHe, yKa3blBaeT Ha OCO6CHHOCTH (JH3HOJIOrJH
OTIIX BHpyCOB H Cnoco6 FIX HHTaHHA. 3KCHepHMCHTI JIbHOe H3y1eH1IC
nieXflH143Ma gCf1CTBH9 3THX npenapaTOB npeJcTaBJI1CT HI1Te;peCHeiinly1A)
ii 6jiarojjapHyio 3ajjaoiy. IoKa MO}KHO I3bICKa3aTb TO.TIbKO FFIIIOTC3\
TOM, 'ITO 3T11 npenapaTbi HOAaBTHIOIUHC HyKJlertl[OBbIIr 06MeII, KOII-
i vpIIpy10T C aMIIIIOKIICJIOTaMH, Hy}KHbIMH Aim nOCTpoeHn51 Brip/Ca
11VMbi I1JIOTOBJjnhIX, nJIH 'ITO Y Jjam1OrO BHpyCa HMCCTCFI IIoBbIllIeHHalF
'I\BCTBnTCJIbIIOCTb K n36bITKy 3THX aMIIHOKHC.IIOT. )JISI pa3MHON{CIIH5T
BCpvCa 'Ij'Mbl HJIOTOSIUIIb]X, I10-BHJ(IIMOMT, HMCCT 311a'IeHI1C (bOJIHeBa51
KIICJIOTa, T3K 110K aMHIIOIITCpIIH, KOK 113BCCTIIO, SIBJISIeTCF ee aHa-
JI(irO'M.
3 CB5I31I C 3TI1M y`-ICCTI-IO OTMCTIITB BhICOKH1I TepaneBTnoecKnu
3(l)(t)CKT, 1I0JIy'IeII11131! H 0,11TOii 113 BCTCpHH0PHbIX ,i1C'IC611H1 I'VIOCKBbI
GCTeDl ll:lpilb[M Bpa'IOM B. A. I1BanOBHTM np11 TIC`ICFIHH IJIIOTaMHHO-
0011 KOIC.1IO"[Oil TH KC'Halx IICpBIIbIX (1)OpM 'IyMbI Y c060K. 113 3 6e3IIa-
J(Cililn>iX BBIFIICHTOi;, JIC'-IIIBIIIIIXCI! b' 1953 r., 2 r,bl3Jjo )oncoH 6e3 BCB-
MIX noCJIC, cTBI1I1, B TO BpCMR KOK 60JIbiibie CC6aKII C I11a.'IOr1I'IHL'IM
npoi eCCO?.1, 110 110 1IOJly'Ii3BnlIle r.'IIOT3^.1HnOBO;I KIICJIOTHI, BCC I1Or16JIH.
hpncc: C1HIhIC ) aIIHh1C JjaJOT OCIIOBaiIIIC Ilepl'IIITI1 K pa3pa0OTKC
MCTO%_jOB IIp1i'.deHCHHSI rJIIOTaMnIIoBOi1 KIICTIOTLI H IIOpJI611t,IIHa JIJI`S
XIL','lnnTepanIIII 11 XIIMnonpO(l)HJIaKTHKH 'IyMbI H.TIOTOAJjHbIX.
0 FEHETI9ECKHX CB5135IX C APYFHMH BHPYCAMH
B JIIITepaType FIMOIOTCSI rIpoTIIBope''InBhIe HJIH TpC6ylOLUHC noJj-
TL'epac lehIHH II CneUnaJlbHOrO I13yileHIIc3 JjalIllble 0 6JI143KnX reHeTH'le-
CKIIX CBASaX BHpyCa BlyMbi iriur HJjHbix c BnpycaMli rpimiia (lIMHAT,
1919, KaIITOpoBH'I, 1925, BpnaH, 1929, KHH, 1934, FIaii,nh n E)Kx-
ropH, 1934, Feiirep ii Beilc, 1944), 3HUC(~aJlnTa KJIHHra (Ope,ab ii
J1IJIb6('pIHTe11H, 1926 n Jjp.), 1,111(1)CKILHOHIIOFO 3nije(~)aJIOMne.TIIITa
IiJIOTOB 1TbIX (iKa(lacco Ii KOKc, 1952), noJIHCMnesInTa ( iopail, 1934,
j ,a.Tlb. Opc~ It Jtp., 1938, MapT3H, 1948, 1950, 1953, Fop:-) H ?ipyrne,
1950), KopIl (FT. F. CepcueB, 1953, B. M. ;ljanoB, 1953), a3naTcKo15
'(VMHI fTH1 (PHraH H JgpyrHe, 1952). OTMe'Ie1I T0K KC cH.M6H03 C BH-
pyCaMH IIbHJeKunonlloro I-C1I ITFTa H JIHM(kOU1,TTapl-IO0O XOpHO !1Iehinhi
rHTa.
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KYJIbTHBHPOBAHHE BHPYCA 'IYMbI
fIJIOTOAJjHbIX
OCHOBoi yCHexoB cOBpeMel-IHOfi BHpyCOJIOI'H'IeCKOI3 HayKH HBJIH-
R)TCH CIIOCO6bI HOJIygeJIH5I BHpyCOB B KOHgeHTpHpOBaHHOM BHJe ii
B HeO6XOJJJMOM KOJIH'IeCTBe.
,IIojiroe BpeMSI CTIHTaJIH1LITO BHpyC TlyMbI rlJIOTOSf,i(HbIX cnoco6eH
pa3MHOJKaTbCH TOJIbKO B OpraHH3Me BOCHpHHMLIHBbIX }KIIBOTHbIX.
3HaT-IeHHe KYJIbTHBHpOBaHHH BHpyca T3yMbI IIJIOTOSI,IjHbIX BHe Op-
IaHH3Ma X035IFIH'a OTMeTHJIH JIeIijjJIoy m ,eHKHH (1929). BHepBbIc
HCHOJIb3OBaB B 1926 r. B Ka'IeCTBe JIa6opaTOpHOri MOJjeJIFI a(~pHKaH-
('KOrO XOpbKa, OHH TeM He McBee 3a5JBJIBJIH, 'ITO KeFILJ naTOJ1orHLIeCKHe
B MCHCl1UB XopIloaJIJIaITTOHCFIOH 06oJ1o IKFI H CO,gep?KaTCSI 6cJiee
nbICOKIIO Titrpbl BHpyCa.
Xafir ioJ[LicpKiiyJi 6e3ycnelHHOCTb ero HOnbITKH KyJIbTHBHPo-
r,aTb BHpyC LIYMOI IIJIOTOAJIIIbIX var. putoriuS B ]KeJTTKe, aMHHOTHLIe-
CKOII H OJIJI0FITOHCHOH HOJIOCTHX PK3, LITO B OTIIOLTICHHH iHeJITKa COB-
rTajjaeT C pe3yJIbTaTaMFi HCCJIe,LOBaHIIH I-ICpKaCCKOrO H npOTHBope-
[UT HC6ojIbLHHM OIIbITaM KoiiaaKOBa.
Ka6acco H KOKC HPHBOj 5IT (1JaKTI1OCCKHH MaTepHaJI, noJTBepA{Jja-
IOLL[HH 3(J4)eKTHBHOCTb McTOjia aJ[aH'raTjHH BHPYC0I3 K PK3, pa3pa6o-
TalIHOrO LiepKacCKHM UyTCM MHoroKpaTHbUX nepeK',peCTHbIX Cy6HHOKy-
:[AIjHYT BHpyCa OT OCHOBHOFO X032HIia K PK3 H o6paTHO. HO McTO-
J>;FIKe, OTJIHLIa1OLL[eHC5I HCKOTOpbIMH ,gCTOJISIMB, HO B OCIIOBHOM
ali0J!O1'IILIiIOFI MOTOjjIIKe 4epKaCCKOrO, Ka6acco H KOKCY, yJjaJIOCb pa3-
MIHO}KIITb Ha xopIIOaJTJIaIITOICIIOH 0600otIKe PK3 BHpyC LIyMbI nJ1O-
TOAJjHbIX, BbIJjeJICFIHbIH B 1941 r. OT LIyMHOH co6aKH, 11 flog Ha3BaH14-
(M Urr aMra J1ej ep.ie noJJ ep)m4BaiOL1 HHCA naCCa3KaMH rJiaBHbIM
o66pa3oM Llepe3 I(j)PHKBHcKiix XOpbKOB.
PIa lnnaH c 9-10 Hacca}Ka, y oacTIi PKD XOP110aJIJIaFITOI3CHbre
o60JIouuKH yTOJILI ,IIOTCA, JjejIaK)TCA BJIwKHbIMII, Ha HHX HOHBJIFIIOTCA
ATIIOI'OTIHCJICHIibie (1)OKyCbI, KOTOphie yBe,.THmHBalOT( 3 B COOTBeTCTBHH
C LIIIC.ITOL1[ IIaccailieli. 11ocJIe 74 nacca)ieFl xo;pliOaJIJ!0IITOHCI-TbiC O6o-
J!o'1K11 PK3 CTai10i35ITCA TOLTL,e, a MIIOrOHFTC.TICHHble (t)OKVCHb1C nopa-
i!:CIITIO 'IIOC51T JjOBOJII IO THACCJIb1H XapaKTep> 11 HMCIOT .
IlpoBo,TwJTOCa HO 4 CCpHH naCCa}KCi BHpyca LIePe3 PK3. B cepHH
6i,uio HO 12-15 PKD 7-,RI[ealloro 1'o3paCTa, KOTOpble FIHKy6npo3a-
JITICb; o 5 jinef npH 35 HJIn 38? C; K0AK;ta51 CePHA 3apWKaJIacb 0,2 Mn
CV'CHell3FIH XOpI1oaJIJIauTOHCIIbTX 06oMTOLICK HpcubTAynleo cepHH. 3a-
TCNI CyCHCH3IICH 0,5 MJI Hoc?>eiiiero naccaoKa 3apaAK IJIOcb no 2 xopb-
Ka. XopbKH 3a6oJleBaJIH LIyMou H r116JIII. H3 HHX BbIJIejIAJICA BHpyC
If BIIOBb ITpou3BOJjUI3fCb n.acea}Ml LTepe3 PKD-, MOTCPIIaJIOM I ocJIeJI-
Hero HacCaa a onlTb 3apax(aJlacb CJIeRy1OUjaF napa XOPbKOB H T. 1.
13 pe3yJ1bTaTe 61mJIo noKa3a110, "TO BHpyc Me>iKeH BHpyca TlyMhl f.IOTOHAHbIX, oxBaTHBIIIHe B o6tuei CJIO)KHO-
CTH 297 PKD. BHpyC BBOAHJICH Ha XOpHOaJIJIaHTOHCHyIO O6OJIOT-IKy H
B aJIJIaHTOHCHyIO IOJIOCTb, H TOJIbKO 10 PKD B aMHHOTHT1eCKyIO HO-
J1OCTb H 8 PKD B }KeJITOYHbIR McIIIOK. B KaN{J oM nacca>Ke yTIaCTBO-
BaJIo no 3-4 PK3, HHKy6HPOBBBmHecH HpH 36 H 38?.
Ha.nHqHe BHpyca B xopHOajLJIaHTOHce, aJIJIaHTOHCHocl )KHAKOCTH
H B Teiie PKD, 1, 3, 6, 9 H 13 nacca){eir B nepBol3-cepHH, B 1, 5, 10, 12
H 14 nacca>KeI'I BTOpOI-I cepHH H B 3 nacca>Ke TpeTbeli CepHH onbITOB
6b1J1O nOKa3aHO nOJIO>KHTeJIbHbIMH pe3yJIbTaTaMH 3apaN{eHn51 17
(no 1-2 IIIeHKa Ha OnbIT) CO6aYbnx WeHKOB 1,5-2-MCCH11HOr0 B03-
paCTa B I H 2 cepnn OnbITOB H 2 IUeHKOB B BO3paCTe 3-4 Mec}IueB B
TpeTbeli CepHH OnbITOB. McHKH, 3apa>KeHHble MaTepnaJioM 17 nacca-
NCa H3 nepBOH cepHH, 20 naccaN{a H3 BTOpoi cepHH n 6 nacca>Ka H3
TpeTbei CepHH OnbITOB, OCTaJIIICb 3AOpOBbIMH, a npH nOBTOpHOM 3apa-
31Ce.HHH 3aBeiioMO BHpyfleHTHbIM MaTepHailOM 3a60JIeJIH T1yMoI3 H naJIH.
Ha xopHoajljiaHTOHCHbIX o6oJioTIKax 12-34% 3apaN{eHHblX PK3
o6Hapy'KHBaJIHCb 20-40 OKpyrJ iax CJOKyCHbIX nopaKeHnc BeJIHT1H-
HOH C 6yJIaBOTIHyIO roJIOBKy, He npOCBeTIIIBalonwxcB, C abIMgaTbIMH
KpaHMH. H3MeHeHHH 9TH HaH6owIee pe3KO Bblpa>Kenhl Co 2 Ao 10 nac-
caN{a, a 3aTeM crJIa KHBaIOTCH H He3aMeTHbI. DTO coriiacyeTCH C AaH-
HbIMH 11JuoMMepa, HO He CXOZHTCH C aaHHbIMH apyrHx aBTOpoB.
COrJIaCHO AaHHbIM A. B. AKyJIOBa (1949), y PKD, HHOKyJIHpO-
BaHHbIX BHpyCOM, OTMegaeTCH Ke LUTaMM BHpyCa
BeAeT ce6H HO-pa3HOMy. TaK, HarpIMep, B OAHHX CJIy'TaHX yJlaBa-
JIOCb HaccHpOBaI{He BHpyca uo 22 Hacca}Ka, a B ApyrHx - Ao 14 H
,aa}Ke 'rOJIbKO AO 5 Hacca}Ka (cM. puc. 6). KHBOTHbIX, 110
coxpaHHeT CBOH aHTHreHHbie CBOfICTBa. KaK npaBHJIO, H3 Ka}KAbIx
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
4 ILjeHKOB, 3apa}KeHHbIX q)HKCHpOBaHHb1M BHpYCOM, TOJIbKO OIIHH me-
a{OK MO?KeT pearHpOBaTb JIerKHM nepe60JIeBaHHeM. UpH IIOBTOpHOM
4KOHTpOJIbHOM) 3apa}KeHHH BHpyJIeHTHbIM BHpYCOM Bce 4 IueHKa He
V-A (wP,Hok
bon, iuti fuo,n/
.4" Pa5uutu
C) Pk3
? Hunge
O Bapyc -q~ur c
O L]blfoponlxa
0 Rldepnbie dpumpomimb,
P3r11 PeaHUILP 3adep)KNU 2PMOQ22i1MQTIWat{UU
PH PeagwjA Heumpan113auIu W:*>-~
PHC. 19. CxeMa HonygeHHH H HaeHTH4)HKaUHH BHpyca-4HKC
vymbl HJTOTOHA,HbIX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
jIOJDKHbi 3a60JieTb 9yMoii. B nocJieJ ylonleM q)HKCHpOBaHHbIIi BHpyC
MOWKeT KyfbTHBHpOBaTbCH B PK3. 0/waKO OnbIT aBTopa nOKa3a.i, 9TO
CJIHnJKOM /IJIHTeJibHoe KVJIbTHBHpOBaHHe BHpyca-(PHKC B PK3, i axie
rlpii nepeKpeCTH09 Cy6HHOKYJIRUHH CO6a4bHM ILIeHKaM, BCJ eT K TOMy,
4TO 611OJIOrHgeCKHe CBOACTBa (IJHKCHpOBaHHOFO BNpyca CTaHOBSITCH
Ece 6oJiee jjaJieKHMH OT co6aK H )IpyrHX nJIOTOHAHbIX }KHBOTHbIX.
Haw McTO/j MHoroISpaTHblx nepeKpeCTHbIX Cy6HHOKyJIAgHIi
BHpyca 4yMbI IJIOTOA)IHbIX OT X03HHHa K PKD H o6parxo
HMeeT 60Jiee . mnpoxoe npHHIIHnHaJIbHoe BHpycoJlorHtlecxoe
311ageHHe, TaK KaK nO3BOJIHeT HanpaBJieHHO H3MeHHTb HaCJieq-
CTBeHHOCTb BHpyCOB H nWJIy4aTb aBHpyneHTHble BaK1[HHHbie
11ITaMMb1, (~HKCHpOBaHHbie K PK3. CCbIJIKa me B pyKOBO/ICTBe FyTH-
pa, MapeKa, MaHHHHrepa H Mo'H (1954) Ha C. A. gKOBJieBa (1950),
KaK a13TOpa JZaHHorO cnoco6a, HBJIHeTCH He/ICpa3yMeHHeM (P. MaH-
HHHrep, 1956, JIHqHoe coo6l [eHHe). 1KOBJIeBy npHHa,gJlexKHO, 4aCTH4HO npHo6peTaeTCR B npouecce HH()eKIIHH
4YMHbIM BHpyCOM.
BJIHRHHe nepeMe}KaH)H(e%CH TeMHepaTypbi
BHpyC 4yMbI nJIOTORAHbIX var. cants ROBO.JIbHO yCTON4HB K KOJIe-
6aHnRM TeMnepaTypbl BHeIUHeii cpeabl. TaK, no aaHHblM 3yAeHaOp( a
H rpUHa, BblcvtHeHHbIN BHpyC, XpaHHBHIHIiC51 107 jlHei npH 7? H nome-
u1eHHbIN Ha 12 Jllierl B aBTOMO6HJIb, HeCMOTpR Ha xKeJ1HKepy H f eJIJIaCH BHPYC 4yMbI, KyJIbTHBHpyeMbli B PK3,
HHaKTHBHpyeTCH 4)opMaJIbJLerH,JOM: 0,1 % -- B Te4eHHe 2 4aCOB,
0,225 % - B Te4eHHe 10-20 MHH.
Kap6o noBaR KHCJIOTa (1%), no JjaHHbIM IIyHTOHH, HHaKTHBHpyeT
BHPYC 4epe3 CyTKH npH 37? H 4epe3 2 CyTOK -- npH 20?. 9TH AaHHble.
6b1JIH nOATBep)KAeHbl (DHHUH (1928).
JIeAAJloy H LeHKHH TaK>Ke npHMeHHJIH Kap6oJTOBy10 KHCJIOTy, HO
OTMeTHJIH, 4TO HaH60Jiee 9CJCpeKTHBeH 1 % J11130JI. Ho F. TI. PaJ(3H-
BHJIJIOBCTKOMy (1933), 6O.nee 9cp4JeKTHBHa 1%) Kap6OJiOBaH KHCJIOTa.
fIO I{?Ke.IHKepy H f'e. naCH BHpyC HHaKTHBHpyeTCH 0,5% CpeHOJIOM
4epe3 48-72 4aca, a 0,75% cpeHOJloM - 3a 10 MHH. Flo aaHHbIM
9THX }Ke aBTOpoB, BHPYC HHaKTHBHpyeTCH 0,3% XJIOpOC)OpMOM 3a
10 MHH. H npenapaTOM Hacca>Kei, 6bIJIH 6e3ycneulHbl.
Coo6uieHHe B. A. fIaHKOBa (1950) O CIIOHTaHHbIX 3a60JIeBaHHHX
11 3rH300TH51X 4yMbI fJIOTOHIAHbIX y KpOJIHKOB HIBJIHeTCH eAHHCTBeH-
HbIM B JIHTepaType H IIHKeM He uOJjTBep)KJLeHO.
Ha BocnpuuM'HBOCTb KpOJIHKOB K CnOHTaHHOH 4yMe nJIOT05IAHbIX
6e30CH0B3TeJIbHO yKa3aJIn TaK)Ke C. 14. JIK)6auieHKO (1954)
H A. A. CJlyaCKHH (1954). fIaHKOB 0006IIIjnJI o6 yAa4HbIX OnbITaX
BKCnepnMeHTaJIbHOro 3apa}KeHHR BIIPYCOM 4yMbI FIJI OTOHA.HbIX KpOJIb-
4aT B B03paCTe OT 2 HCaeJIb AO 1,5 Mec.; B3pOCJIble KpOJIHKH K...MeHee
BOCnpuHM4uBbI K 4yMe, 3a6oJIeBaHHe IIpOTeKaeT Y HHX OTHOCHTeJIbHO
JIaTeHTHO... upn c ia6OH BbIpa>KeFIHOCTII K.JIHHH4eCKHX npH3HaKOB B
Tegenne HeCKOJIbKnX McCHIueB> .
lIo MapTBHy (1950), BBeaeHHe no oco6oH McTOAHKe Kp0JIHKaM
"Bnpyca 4yMbI nJIOTOHAHbIX var. canis (cycneH3HH CnHHHoro M03ra
co6aK, CTpaaaBHIHX KJIaccngeCKOH HepBHOH 4)OpMOI3 4yMbI) B 40%
'CJiy4aeB BbI3bIBaeT KpaTKOBpeMeHHbIH (2-3 RHH) He60JIbWOH
noa"beM TeMnepaTypbI (AO 1?), 5IBJIHIIOI1 WHCHI eAHHCTBeHHbIM BHeuI-
HHM npOHBJIeHHeM 3TOH HHCpeKLHH Y KpOJIHKOB. Ho Mepe naccnpo-
BaHHH Bnpyca 4epe3 KpOJIHKOB CMepTHOCTb aOCTHraeT 70-80%, a
y BbI}KHBUIHX, B 60JIbUIHHCTBe CJIy'aeB, B03HHKaeT HMMyHHTeT. OA-
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HaKO MapT3H nOATIepKHyJI, I-ITO nepeHOC BHpyCa OT C06aKH K KpOJIH-
Ky OcyLueCTBJTHeTCH HeperyjlHpHO, 3aBHCHT ? OT MHOrHX MOMOHTOB,
npHTIeM KPOJIH4HI( BHpyC Hei TpaJIH3yeTCH npOT}IBOTIyMHOIi CbIBO
pOTKOI3.
flpH nepeHoce BHpyca OT KPOJIHKOB o6paTHO Ha C06aK TaK>Ke
6bIJIH nojlytieHbI HeOAHOPOAHble aaHHbie: co6aKH, 3apa}KeHHble BHpy-
COM, naCCHPOBaHHbIM tiepe3 KpOJIHKOB, pearHposaJlH TOJIbKO KpaTKO-
BpeMeHHbIM nOBbIuJeHHeM TeMnepaTypbI H y nOJIOBHHbI cO6aK He y,a=
JIOCb BbIAeJIHTb BHpyC.
HeCTa6HJIbHble pe3yJIbTaTbI jjajIu OnbITbI MapT3Ha, Fop3 H apyrHx
(1950) no aaanTaLunn KpOJIHKaM BHpyca TIyMbI IJIOTOSLAHbIX var.
pitorlus. Tax, H3 6 3apa3KeHHbIX KPOJIHKOB pearlpoBajl Bcero QAHH.
IIpH nacclpoBaHHH MaTepHaiia OT 3TorO KPOJIHKa y 3apa}KeHHb1X
KPOJIHKOB OTMegaJIacb TOJIbKO TepMHTIeCKaH peaKUHSI. Home 14 nac-
caxceli 60% 3apa}KeHHbIX KPOJIHKOB norH6JIH. fIOJIOBHHa Apyroil
CepHH OnbITOB 6bIJIa OTpHIjaTeJIbHOI-I: 3apa]KeHHbie KPOJIHKH He 3a6o-
JIeJIH. B 3 cepiiH OnbITOB 6bIJIo nOKa3an0 HaJIHTIHe nepeKpeCTHOro
BMMyHHT'eTa, TITO yKa3bIBaeT Ha BO3MO)KHOCTb aAanTaunn Bnpyca
YyMbI IIJIOTOH,aHbIX var. putorius K KpOJIHKaM. OjjHaKO 3aKpenHTb
3TH pe3YJIbTHTbI H 3aKOHOMepHO nOJIVTIHTb KPOJIH1IHI3 BHPYC He yjta-
Jlocb. Ho3AHee f op3 H jjpyrne (1952) coo6IUHJIH, LITO BHPYC LIyMbi
HJIOTOHAHbIX, npouIejlulnI-I 13 H 6oJlbLne nacca?KeI3 Tlepe3 KPoJIHKOB,
Tep5IeT H BHP JieHTHOCTb H HMMyHOreHHOCTb.
OnbITbI flaHKOBa, a TaK3Ke MapT3Ha H rOp3 nPOTHBopeTIa-r Apyr
apyry.
110 MapT3Hy, a 3aTeM no rOp3 H MapT3Hy, KpOJIHKOB TIyMOI-I HJIOTOHAHbIX. rlaH-
KOB ]Ke Ha6JuoaaJI pIHHT, KOH'bIOHKTHBHT H ApyrHe KJIHHHTIeCKHe
5IB.IeHHH, npHgeM . Ho MapT3Hy H apyrHM, Ha ceKLjnn xapaKTepxo
yBejiHLIeHHe CeJie3eHKH KPOJIHKOB B 4-20 pa3 (no Becy) ; no r1aHKO-
By 3Ke naTOJioroaHaTOMHTIeCKne AaHHbie He XapaKTepHbI, a ceJle3eH-
Ka KyMeHbLUeHa B o6'beMe>.
MapT3H, tops H Apyrme coo6LualoT o rH6eJIH OT 60% jto 80%
3apa3KeHHbIX B3POCJIbIX KPOJIHKOB; no HHaHKOBy OHH nepeHOCHT HH-
(~CKUHIO JIaTeHTHO H Aaxce OKa3bIBaIOTC51 BOBCe HeTIyBCTBHTeJIbHbIMH
K Hell. B OnbITaX MapTBHa, tops H Apyrxx BHpyC OT KPOJIHKOB
HH()HHHpyeT co6aK, a no rlaHKOBy OH FIX HMMyHH3HpyeT H T. A.
B coo6iueHnHX flaHKOBa o6pa[uaeT Ha ce65I BHIIMaHHe He000TBeT-
CTBHe Me}Kjiy BbICOKOl3 KOHTaIHO3HOCTbIO H CMePTHOCTb}O KPOJIHKOB
npn CHOHTaHHOM 3a6oJIeBaHHH H CMepTHOCTbIO B BKCnepHMeHTaX.
rlpu CnOHTaHHOM 3a60JIeBaHnn-100% CMepTHOCTH, a B OCTPbIX onbI-
TaX BIIBOe McHbLue-50%. O6panuaeT Ha ce5 i BHHMaHHe H 66JIbiua5i
BOC1PUHMTIHBOCTb KpOJIHKOB (H KOTHTI) K BHPYCY TIyMbI fJIOTOIAHbIX
var. canis, T-IeM LueHKOB co6aK. TaK, H3 13 nOAOnbITHbIX LIjeHKOB naJIH
TOJIbKO 4 (H 3 3a6HTbI), B TO BpeMH KaK naJLe K KPOJIHKOB 6bIJI 3Ha-
'?IHTeJIbHO 60JIbliie, a y KOTHT COCTaBHJI 100%. He COBCeM HCHbI H
HCKOTOPbie .i pyrHe McTOAHTIeCKHe BOHpOCbI H YCJIOBH51 nOCTaHOBKH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
3KCnepHMeHTOB. TaK, BBeJIeHHe 10-12-JHeE[HbIM MKHBOTHbIM BecoM
B. 260 r Jo 25 r BHpyCHOH cycneH3HH, T. e. Jo 10% Hx Beca H JO
85% o6'beMa Bcei LHpKyJIHpYIOLueH xpoBH, KaK 3T0 aeJiaJi r1aHKOB,
He r103BOJI5IeT cLIHTaTb HaCTYHHBLIIHH naTOJIornLIecKHH 3(J4eKT CneuH-
4)HLIHbIM. TaKMKe HeHpaBHJIbHO 6bl.llo CYJIHTb 0 LIyBCTBHTeJIbHOCTH
KPOJIHKOB (n KOLueK) K HeO6bILIHOMy JJI51 HHX naTOreHHOMY B036y-
JIHTeJHO HyTeM KOHTaKTa c 60JIbIIbIMH BMeCTO np51MbIX OCTPbIX Onbl-
TOB HCKyCCTBeHHoro 3apa KeHHSi )KHBOTHbIX - X035ieB, rapaHTHjpyK)-
LH.HX 3KCneplMeuTaTOpa OT HenpeABHJeHHbIX CJIyLIavHOCTel.
ELue 3ec4 pHJ (1930), H. H. CaxapoB H E. H. Fy, KOBa (1952)
IIOJ IepKHyJIH BO3MOMKHOCTb HyTaHHubI H HeO6XOJHMOCTb HCKJIIOT-IH-
TeJIbHOH OCTOp0MKHOCTH HpH pa60Te c HeIpoTponHbIMH BHpyCaMH Ha
KpOJIHKax. ae.iO B TOM, LITO KpOJIHKaM CBOHCTBeHHO CKpbITOe HOCH-
TeJIbCTBO BHpyCa KpOJIHLIbero 3Hue(ka.i0MH3JIHTa H JlpyrHX HH(.))eKuHH,
Bb15IBJI5IIOIIIHXC5I JIHLHb noc ie HHTpauepe6paJlbxorO BBeJeHHH HCnbI-
TyeMOrO BHpyCa HJIH Ja>Ke CTepHJIbHOro MaTepHaJla. H03TOMY yKa3aH-
Hble aBTOpbI npaBHJIbHO HaCTaHBaIOT Ha npejBapHTeJIbHOM KOH-
TpOJIbHOM Bb16OpOt1HOM 3a6oe }KHBOTHbIX, rHCTOJIOrH11eCKOM HCCJIeJO-
BaHHH MO3ra H JIHKBOpa. F103TOMY He06XOJHMa HJeHTH(JHKauHH
KpOJIHLIberO BHpyCa CepOJIOrHL1eCKHMH H HMMyHOJIOrHLIeCKHMH McTO-
JaMH. TaKa5l nOHbITKa 6bIJIa CJIeJIaHa MaPT3HOM H Fop, HO He r1aH-
KOBbIM, OJHaKO pe3YJIbTaTbi 6bIJIH HeJOCTaTOLIHO LIeTKHMH H noiILiac
npOTHBOpe'IHBbIMH. CJieJoBajio 6bI HCKJIIOYHTb LIyMy KpOJIHKOB, OHH-
caHHyio /1HCeHOM (1941), HMeIOIuyIO CBOT[ O6oCO6JIeHHbIH BHpyc,
HT. J.
Eeilble JYlbUUU yCTOHLIHBbI K LiyMe UJI0TO5IJHbIX (JcHJIJIOy H UCH-
KHH H ,p.). E. C. LlepxaCCKHH H C. E. Copnna (1949, 1951) 3apa3H-
JI14 B M03r H BHyTpH6pIOHIHHHO 3 LrTaMMaMH BHpyca 280 MbILIIeI H
npoBeJIH CepMIO KCJIenblx> nacca>KeF. 1-1OJIOBHHa 3apaMKeHHbIX MbIIIIeI1
6bIJIa 3a6nTa Ha 6--7 aeHb, a 3a JpyrOH nOJIOBHHOI-I Ha6JIIOJiaJIH ,go
30 jncR. HH B OJHOM cJIyLlae He 6bIJIO HHKaKHX npH3HaKOB cneuH(IJH-
3ICCKOrO 3a6oJIeBaIIn51: IIpH HHTpaHa3aJIbHOM BBe)IeIIHII (Xair,
1948, 1949) Ii npH BBeJCHHH HIITpauepe6paJ1bHO no 0,3 M.II BbICOKO-
BHpyJIOIITIIorO BHpyca HyMbI fJIOTOSI)IHbIX var. putorius (Ka6acco H
KoKe, 1949) MblIllu TCKMK0 He 3a6oJicJIH.
OipHuaTC.nbl[bIC pe3yJibTaTbi noJly'iuaH Ka6acco II Jp. (1955)
HpH 5 1lacca KaX Bllpyca LyMbl, aJanTHpoBaHHOrO K PKD, na 1-2-
JIIICBHbIX MbIHIaX; oJ11aKO 3TOT BIIpyC, npOlneJILHHH 2 BuIyTpHMO3rO-
BbIX IIaccaMKa 9ep03 COCy'IIKOB-XO1145HKOB, cnoco6eu IIacCHpOBaTbCSI IIC-
pC3 MO317 MbILHCH-COCYIIKOB.
Oco6oro MHCIiHH npllaepMKHBaeTCSI Mancen (1949), CLIHTaIOIuHH,
LITO B npupOJie unpKyJlHpyIOT pa3JIH1IHb1e LIITaMMbI BHpyCa LIyMbI
nJIOTO51,L HbIX, B TOM uuc ie >. OH co-
061uHJI, LITO, fOJIb3y5ICb TaKHMII IIITaMMaMH BHpyCa, ewe B 1944 F.
HHTpaLIepe6paJIbHO 3apaMKaJi MbI ueH, H3 KOTOpbIX 80% norl6aJio npH
CHMnTOMaX, XapaKTCpHbIX Ji,JI5I LIyMbI. OJHaKO npOBepOLIHbie pa6OTbI
pSu i,a aBTOpOB He nOJITBepJIHJIH JaFIHbIX MaHCeH, ,aa H OH cam f03J-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
~~,(,11);uo{?l~l;~o- ooaT?~iii= P1~,~ gh3apiWjq
MbI I i B M HQ#PP OI & 1 : ~a +PYf ~cr~~~ I bIIC'e~ilii~
B#iP.3i~IRI Y EkP a Fos [ c: RA&HT po$ pRrQ
mfm
K:'~ Tf~{+M:'IlaMf f?1pTa~p Illlllal*; Poo
AP~erit.?~;. iRYr R X 95 .:;k~pr ueP~~~P ?r cxR1Rfl ~d-t~cr 1-*rf
HM H::1_4fjP P~?)? IYIlIII g~kl~ d~ ~Ix,I:a nT R? a~1#~# #_
1 accxP14~~~d :12. at'3Hx ?, '?a sRT1' II~Ik r75s? rI 4R1 :; ep~
Pq A~HR, A a4 axcetl .,a,.2 m om 10I4'-QP -
xcel3 tIepe3 MblxleH. s ~4pe r~r0 >rIA~ 4:c a? g: ERR ^~r4 t, kW rI?c,I~g
j a 1k H P. ' r K:g#~~: Tisch ie?:r~i AKije,3 A P~I?ff# t cygo orx,
Ir *r$;R9,Vb a4atux por . .,,,BHpyfTWigQ !l.14 Ir x:Ai '*
*a4il it 9PxoaJt rile Q ce 'K ;~sHni3tllll ~; Q _ ala6o Bblpaxc H bigcrw-
paSKeHHx. BHpyc ~TQ; He I0# :t? aTare etjr. i; eoob Ga~.IIH fIX rTi~
aPRR~Kit!4PPb!.`3I1 P.Hi?')ii UA,::''(4:?I!II"3I:"~' Illlltrii?OI: 2;`
:i,1}ft;iPTib1T?Xu;4FIIX ,aTRP44 _WY( Tp%QHkW1:Qiiplry TpHMp3RRBbl
I}a { I ;H> ;I~O~Ylbaax~~ep 44a IP?tlil tRa?i i ;,?a6oi eap rie~.'jIl liora
c~PT1k1fR13>.3 PKYOEl4RxH~IH _ :IaQPxi'3i~`;"rIIQARIr c1lfl~CC41~I'. ~~lll
7 aHeH, a 3aTeM CHH3HJICH Ro LIeTbIpex. THTpbI BHPyGa;;$,.iMQRCJi)1?4~ilil-
MHKOB AOCTxrKa~jiH 3,2) 'ao~LLI0-I4. BHHpyc 4, 7, 10, 11 Hb13 nacca-
)KeH Ha J~Q,-?1 ~! tt(I,iFllcltltl.P~i3 jI BaPIIcCtg9di`,i, ltiiiL ri}nJIOTOHJJ
HbIX var. cants B peaKL~ItI ~-I'g ~paf.i~3ajL ,c1) HMM HOx CCbIBOpOTKOII
co6aK H HyTeM 3apa2KeHHH ai~ HKaHCKHX XOpbKOB.
~Iargg~tca~f~P~iy.:~i'i anPlyyctbz,t.8w,
.3e JpH I *,a A R C II3a' )K IH I :R9cJ J fl~$E$ ~,
-Hxno aMC, sa* H~ upu rasl ~rlgfisl 3~P . e' : TT ~1)U"H,
r;,it1? 1~~ au.. ,,x Cxox ;YCPrvvl ? 1? p~ >R IX'r)
SHI~C{a,na al?TXO itT ~uxr Tatc >KaK
OFICfa'ia TII A~ JI~cI2 3a. 1 Ail 4AIAaRb*B SI I. MO ~'c: $ is
kl~
`? Fa I~?rnc:
_;ICPH ~~hI HrI fl"
O F J 6. PTII~q TepffgkI: AycT4xT,Msc7,`1A1OPc i x,f Nq K,.noCr,.
IA~I~A1U MiiY~ P.f,~ITtopjpN' y,4a?PF aaPas Tp 4 ,CBI 4 r:.73
QiP jITK ~ xI:~BT P4 ') , I~fa klT.1~ ME CKHX cH,F,I,OI(jj.,aTYMOHI.IWJJ19TRi
SIAHbIX (acco H 1OKc 14 Ap.) 6bIJIx oe3ycnemnbI. 1i HOHCKBX JIa-
6OpaTOpHOFi ~1IC~lijll4;~c;;lue]~~If3~M;:{~.1~I:ILY~t.yC?IjeJIaHa 6e3-
ycneHlHasl FipTibitgp l~l~laa'ik1SI 4~1dl~e>+63ti::it:::)1 .'ltu:~r;!
B JIFTepaType coTtQpr`#II fI g, HcTpegtio~ H Majloy6eliwTejibxoe
coo6n1 omTe B. A. IlariKOBa (1953) 0 BOCHpHHM'-IHBOCTH .iotuadeu
(6-mccmiiibIX) K 3KcrieWmeHTai)[r9lian,!j-!, 21 #dlla)KeHHio 'IyMOII HJIOTO-
5l,j11h1x.
~~1t,GOA'(7Ti~eIFylQtiBlILIJJT&?II~~i~7~;~II~I ~IiCT~:$I I>(IrReTt~bilQe~~..MbI
n'3IAT05111Tni,i flIHeI:'n1JiyLlnno .AAIIT$~eH fi:;~[I.BI it fJ~I> Hla~4i:llf
ECCM;rl (119&0);
Tu ra I;(119a~C~:>- aabu~ > i;II~, PY!?Ie (~1~ J3; Y14H~
3acame Hai1Bwnf)i4QIm'dwIIRVILm#)1j61tium?e wo3 &WSgy IkI:p4W*
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TO5U HI;1X var. putorius, n031IHee (1938) 0006uiHJIH, 4TO BHpyCHbI11'
MaTepHaJT, C KOTOpbIM OHH paHee pa60TaJIH, 6bIJI He I4HCTbII3, a npe,r,-
CTaBJIAJI CMeCb BHpyca IIYMbI nJIOTOHAHbIX H BHpyca JIHM(pOI);HTapHO-
r0 XOpHOMeHHHrHTa; npHlleM BBeaeHHe o6e3bIHaM OAHOro BHpyca
JIHM(1)oljHTapHOro XOpHOMeHHHI'HTa BbI3blBa.T[O Te )Ke noCJIe1[CTBII57,
IMTO H BerieHHe era B CMeCH C BHpYCOM II)MbI [IJIOTOSIAHbIX. Flo MapT3-
Hy (1953), 06e3b5IHbI BOCnpHHMIIHBbI K BHpyCV 9yMbI riJIOTOHAHbIX var.
putorlns, KOTOpbII3 reHeTHIIeCKH 6JIH3oK K BHpyCy HOJIHOMH3JIHTa H
AaeT C HHM nepeKpeCTHble peaKuHH HMMyHHTeTa.
B JiwTepaType HMeeTC 1 HeCKOJIbKO MaJIOAOCTOBepHbIX coo61ueHHH
O CHOHTaHHOc BOCnpHHMIIHBOCTH iello6eKCZ K IIyMe nJIOTO11IHbIX
(OpHA6eprep, 1881, BeJImKaHHH, 1882, 3e.TrHHCKHIl, JI. HeHUKHI1 H
KapnHHCKHI3, 1894, BpHOH 1929, BpIOHHHr 1938 H Iip.).
Ha OCHOBaHHH ycnelluHOro 3apa}KeHHFf Il;(!HKOB KPOBbIO IIeJIOBeKa,
KOTOPOMY 3a 7 gHe13 AO 3TOro 6bIJI BBeAeH BHPYC IIyMbI fJIOTOHAHbIX
var canis, HHKOJIb (1931) npHHIeJI K BbIBOAy, IITO IIeJIOBeK SIBJI5ieTC51
JIaTeHTHbIM BHpYCOHOCHTeJIeM IIyMbI H MO?KeT nepeAaBaTb 3Ty
6oJIe3Hb co6aKe.
HHJ1HBH,II,YAJIbHbIIfi ECTECTBEHHbIR HMMYHHTET
K 4YME HJIOTOSIAHbIX
Eiue gejia6ep-BJi3H (1820) o6paTHJI BHHMaHHe, VITO HeKOTOpble
He 6oJIeBHIHe 4yMo1i Co6aKH He 3a6oJleBaIOT, HeCMOTpH Ha KOHTaK'r
c 6oJIbHbIMH IIyM013, H IITO MHOFHe co6aKH HeBOCnpHHMIIHBbI K IIyMe
BCIO )KH3Hb. JIIreH (1911), BHJIJIHHrTOH (1930), F0(4MaH (1943),
t-1epKaCCKHI3 (1954) Ha6JTIoAaJIH, 'ITO }KHBOTHbie OaHoro fOMeTa, B03-
paCTa, nova H yHHTaHHOCTH, 3apa iceHHbie OAHHaKOBbIM cnoco6oM H'
OAHHaKOBO11 A0309 Toro }Ke IJJTaMMa BHpyca, 6oJIeJIH uyMOI pa3-
JIH9HO: OJjHH JIerKO, apyrHe 6oJiee TH)KeJIO, TpeTbH Co CMepTeJlbHbIM
HCXOAoM. HeKOTOpbie co6aKH He 3a60JIeBaJIH, XOTA 0 HHX ROCTOBePHO
6b!JIo H3BeCTHO, IITO OHH paHee He 60JIeJIH. B03MO)KHO, IITO 3T0 6bIJI0
HJIH npOHBJIeHHe BpO)KACHHOFO HHIiHBHAyaJIbHOrO HMMyHHTeTa HJIH
HMMyHHTeTa, npHo6peTeHHOrO B 3M6pHOHaJIhHOM nepHoae, BnocJ[eA-
CTBHH yCHJIHBaBLHeroCft 6JIaroaap9 He3aMeTHOI3 HMMyHH3aILHH He-
60JIbHIHMH A03aMH BHpyca. Bonpoc o6 HHAHBHAyaJIbHOH BOCHpHHM-
IIHBOCTH K IIyMe TeCHO CBSI3aH C OCO6eHHOCTHMH KOHCTHTyIiHH co6aK.
BJIHAHHE KOHCTHTYEIHH, IIOPO1IHOCTH H
HACJIEACTBEHHOCTH HA BOC[IPHHMgHBOCTb
K 4YME IIJIOTOSIAHbIX
BJIHSIHHe KOHCTHTTUHH Ha B03HHKHOBeHHe H! TeIIeHHe IIyMbI nJio-
TOHAHbIX OTMe11aJIH MHorHe yIIeHHe. TaK, euie 3ltrcH, HPHBOaH CJIy-
naH JIerKoro nepe6o.neBaHHH 3KCnepHMeHTaJIbHOIi 4yMOIi, nnca.I,
'ITO B 3TOM 6oJIbiIIyJO pOJIb c irpaiia KOHCTHTyUH I OnbITHbIX }KHBOT-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HbIX, HX xopouiee pa3BHTHe H ynHTaHHOCTb. Hao6opOT, i icenoe Te-
geHHe 3a6oJIeBaHHR OH KOHCTaTHpyeT Y }KHBOTHbIX Co cJia6oli KOB-
CTHTyuHeH.
no Kp3Ky (1930), KOHCTHTYUHH C06aKH npeAonpeaeJlxeT pe3H-
CTeHTHOCTb K tiyMe: C06aKH-aCTeHHKH IJIOXO Bblpa6BTbIBaIOT aHTH-
TeJia H MaJIO yCTOHYHBbi K tIyMe.
BOCHpHHM9HBOCTb pa3JIHgHbIX nOpOA
MHorot1HCJIeHHbwe CBeAeHHSI 0 TOM, qTO C06aKH pa3HbIX nOpOA B
O,gHHaKOBbIX yCJIOBHHX n0-pa3HOMy BOCnpHHHMaIOT H nepeHOCAT
tiyMy, qaCTO HenpaBHJ1bHO TpaKTyJOTC51 KaK KAOKa3aTe.IbcTBO 71 pa3-
JIHtiHOIi nOpOAHOFi BOCnpHHMtIHBOCTH C06aK K t1yMe.
K OCO60 BocnpHHMgHBbIM nOpOAaM npHtIHCJIH1oTCH: MOfCbI H 6op-
3ble ((DyHKe, J1eHTHH, 1948), HeKOTOpble OXOTHHtIbH nopOAbl (BoA3,
1948), LHHHUbI 6eJIoIi MBCTH (J1eHTHH, BoJ3), HeMeuKHe OBIqaPKH
(H..UpeMHuKHIi H H. Pa3yMOBCKHIi, 1931, Bo,3), JIafKH (M. B. I'.,
1932, Ha3apoB), BOAoJia3bl (BceBo.nog0B, 1840, A. (De1OpOBHLI,
1911), nOpOAbI He6oJIbIIHX KOMHaTHbIX co6aK ((DeAopoBHU,
K. B. TypKHH, 1902; H. XoJIMaHCKHX, 1913, MaKapeBCKHii, KaAHO
H BpeTOH, 1937) H ap. 5o.nee ycTOli4HBa K tiyMe rpyriria TepbepoB,
oco6eHHO 3pJe.nb-Tepbepbl (Pacsali, 1929, A. HeMUOB, 1932), 6yJIb-
AorH (B. B. T4aCOBHHKOB, 1930), 60Kcepbi (LIIy.lbue, 1948). LUHp0KO
paCnpOCTpaHeHO MHeHHe, tiTO CO6aKH nPOCTbIX nopOA-c -npaKTHtieCKH He 6OJIeIOT tIyMOH.
MHeHHe o fOBbIIIIeHHOIi yCTOIitIHBOCTH CO6aK, KBK
3KCnepHMeHTaJIbHo nOKa3aJi eme KpaeBCKH1, COBepIIIeHHO HeocHoBa-
TeJIbHO. 3TO, HanpHMep, AOKa3bIBa1OT 3fH300THH tiyMb1 cpeAH co6aK
Ha KpafHeM CeBepe, KOTOpbie OXBaTbIBaJIH HOtITH Bee nOTOJIOBbe
K6ecnOpOAHbIX>> co6aK H AaBaJIH OrpOMHyIO CMepTHOCTb (A. II. KHyp-
MypaTOB, 1940). ay6poBCKHR (1939) coo6IUHJI o rH6eJIH OT tryMbi
50% K6eCIIOpOAHbIX> CO6aK, 3aBe3eHHbIX H3 ApxaHreJIbCKa Ha
HOBylo 3eMJIIO.
IIpOBeJjeHHoe L1epKaCCKHM (1950, 1954) 3KCnepHMeHTaJIbHoe 3apa-
}KeHHe HeCKOJIbKHX COT meHKOB co6aK nOKa3aJIO, TO
LueHKH 3apa}KaiOTCSi TaK ace JIerKO, KaK nopO,i[HCTbie, H TaK }Ke TSH}Ke-
JIO 60JIelOT, eciiH OHH paHee He nepeHeCJIH 6eccHMnTOMHOH HHI)eKIIHH.
LirpaeT pOJIb H KOJIH4eCTBO co6aK B onpeaemmeHHOFi McCTHOCTF
(TYPKHH, (DpHA6eprep H cpeHep, 1908). Tax, B CTaTHCTHKe 3a60J1e-
BaHHH CO6aK tiyMOli B SepJiHHe nepBoe McCTO 3aHHMa!OT MOnCbz, TBK
KaK Ha HHX B SepJIHHe 60JIbIHaH MOAa.
TeopHH o6 oco6oi npe.apacnoJlo>KeHHocTH H oCO6eHHo nOBbdlneH-
HOFi CMepTHOCTH OT tiYMbI HeKOTOpbIX HOpOA Co6aK He COOTBCTCTByIOT
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HpoLHSTtRFIe Bl ft.;:1 I jjpUNAe;AM0CTe j C ylH(,ei3 l'I oo,"TP{m -~HHPOOTW
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JjeJIbHble) He npeaCTaBJIHK)T HCKJIIOLIeHHH B CMbICJIe 3apa}KeHH51 'iy-
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JIHCHIjbI. B O,RHOM nHTOMHHKe H3 41 3a60JIeBLneIi CO6aKH 80% 6bIJIH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B B03paCTe aO 2 JieT, 20%-OT 2 ao 4,5 JieT (raHCMaHH H OJIbu,
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a TaK}Ke BaKUHHHpOBaHHbIX.
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HOM HHTOMHHKe B 1948 H 1950 rr. Mbl Ha6JIloAaIlH 3a6oJiesaHHe H
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Me (BeTeMaH, 1926). EAHHCTBeHHbIM CHMHTOMOM HX 3a60JIeBaHHSI
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Hefi ceKpeIIHH BeAeT K Hapyw HH1O o6Mexa BeILjeCTB H nOBbinlaeT
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LIaSIX 4yMa 06bI'H0 OCTaBJISIeT TSI}KeJIbie nocaeACTBHSI.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
~ Il ppm sai~~~pa iHO [>,ea~ iy;, c r11:.Hp QxIIH ~pyi1H ?I,'jl^O TaTO Hbtli
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MaccHBHOCTb HHc1eKIHH nMeeT orpoMHOe 3Hallenne. Eiue afireH
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TeJIna0bHOn CHCTeMbI H o6pa3OBaHHeM HMMyHTeJI, CHOCO6CTBylO1UHX
He TpaJIn3agHH BHpyca. OAHaKO o6pa3OBaHHe H ()YHKLHOHHPOBaHHe
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HX HaXOJjHTCH nOA BeayH.[HM KOTPOJIeM ueHTpaJIbHOr3 HepBHOIl CHCTe-
MbI H OCyIueCTBJIHIOTCH Ha OCHOBe 3aKOHOB B036y)KAeHHH H TopMO}Ke-
HnH. HHKaKOe allTHTeJIO caMO no ce6e He crioco HO yHH4TO)KHTb
EHpyC; allTIlTeJIO TOJIbKO aKTHBH3HIPyeT BO MHOIO TbIC514 pa3 JjeHTeJIb-
HOCTb C~H3HOJIOPHileCKHX McXaHH3MOB, o6ecne4HBaioajHx nOCTOHHCTBO
BHYTPCHHer3 cpeabI opraHH3Ma. HapHJjy c aKTHBHbIMH 3JTeMeHTaMH
coeAnHHTeJIbHOIi TKaHH peTHKyJIO3HJ[OTeJIHaJIbHOro annapaTa BHPYC
B03,jeACTByeT Ha tJyBCTBHTCJIbHble HepBHble OKOH4aHHH, BBHJjy LIerO
o6pa3yeTCH yCJIOBHbII3 peCgjieKC H 6e3yCJIOBHaI pe4JJIeKTOpHa5i 3aIuHT-
IIaH peaKLHH opraHH3Ma.
Kopa rOJIOBHOI'O M03ra co6aK BbICOKO pa3BHTa n ee peu.IaK)ujee
BJIHHHHe Ha HMMyHOJIOrH4eCKHe npoueccbl npH 4yMe 6ecCHOpHo. AB-
TOP o6paTHJI BHHMaHHe Ha TO, TO yCTaJIOCTb H fOBbIHIeHHaH HePBHa5
B036VA11MOCTb co6aK KpaHHe OTpHuaTeJIbHO CKa3bIBaIOTCH Ha 34x1JeK-
THBHOCT[I BaKUHHauHH. HaH6oJIbuJee 4HCJIO nPOPbIBOB B O6pa3OBaHnH
IIMMyHIITCTa 6blJIO OTMe4eHO cpeAH MOJIOJjbIX co6aK, nPHBHBaBIJHXCH
B HePBble 1-2 JjHH noco'e AJIHTeJIbHOI'O TpaHCHOpTHpOBaHHH no }Ke-
JIe3HO[I ,i opore, COBMeCTHOI'O COAepxKaHHH B KapaHTHIIe c Co6aKaMH,
BrpeCCHBHbIMH HO OTHOnIeHHIO Jjpyr K Apyry, H T. Jj. B uiKo.ne co6a-
KOBOACTBa, B 04are tlyMbl, B npHBbIgH0l-r o6CTBHOBKe BaKUHHHpOBaH-
Hble uJeHKn AJIHTeJIbHO COXPaHHJIH HPHBHBO4HbJl HMMYHHTeT, KOTO-
pblli, oAHaKO, 6bIJI HapyuleH nO4TH TOT4ac we nocne JjaJlbHerl nepe-
BO3KH HjeHKOB Ha aBTOMaHIHIfaX B Jjpyroe McCTO.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BOIIPOCbI 3IIH300TOJIO1FHH 4YMbI IIJ1OTO9JLHbIX
E)nH300TOJlorHH LIyMbI HJI0T0AAHbIX HMeeT pAq 0006eHHOCTeI, 3a-
BHCSIHI,HX OT yCJIOBHI3 coaep?KaHHH, KOTOPble m no CBOeMy XapaKTepy
pa3JIHLIHbI AJIR TeX HJIH HHbIX BHAOB BOCHpHHM1IHBbIX }KHBOTHbIX.
Flo 3BH300TOZTOFHLIeCK0fI KJIaCCHC)HKa11,HH 3apa3HbIX 6oJIe3He1%I,
HpeJJIO}I{eHHOIt M. C. raHHyHIKHHbIM (1948), LIyMa HJIOTOAAHbIX y
co6aK OTHeCeHa K rpynne a3pOreHHbIX HH(jCKH,HI3, HplI KOTOPbIX Cy-
WeCTBeHHOe 3Ha4eHHe HMeIOT BTOpHTIHble HCTO1HHKH 3apa}KeHHH, 'ITO
raHHyIHKHH cHpaBeAJIHBO yBSI3bIBaeT Co cpaBIIHTeJIbHO BbICOKOII
yCTOII'IHBOCTbIO BHpyca LIyMbI HJIOTOHAHbIX BO BHefIHe13 CpeJZe.
0 3apa3HTcJIbHOCTH LIyMbI' IIJIOTOHAHbIX 6bIJ10 H3BeCTHO B gajieKHe
HCTOPHLIeCKHe BpeMeHa. Ho yx{e AeJia6ep-Bi[aH (1820) OTMeTHJI, LITO
OHa HepHOAHLIeCKH yCHJIHBaeTCSI H (IcJ1a6JIHeTC5i, B 3aBHCHMOCTH OT
BHeIIIHHX HBJIeHHI1> .
3HaMeHHTbIfi ,}KCHHep, yAeJIHBIIIHFI MHOrJ BHIIMaHHH LIyMe y co-
6aK, 6bIJI OAHHM H3 HeMHOFHX aBTOpOB, rlepBblMH 3KCHepHMCHTaJIbH0
AOKa3aBHIHX HH(jJeKHHOHHbII3 XapaKTep 3a60JIeBaHHSl.
IIepBoe coo6HUeHHe o6 3rIH300THLIeCKOM TeLIeHHH LIVMbI V C06aK B
PoccHH HpnHaAJIe}KHT M. M. BpaxreJilo (1824).
OTpHgaTe.lbHble pe3yJlbTaTbl HaHeceHHSH KOII'bIOIlK'rHBaJIbHOPO H
IIOCOBOrO HCTe'eHHH co6aK, 60JIbHbIX LIyMOII, Ha CJIH3HCTyIO Hoca
3J1.OpOBbIX cO6aK HPHBCJIH DpHA6eprepa (1881) B o6111eM K HpaBHJIb-
HOMy 3aKJIlotIe11HK), 'ITO LIyMa He BO BCeX CTa, HAX 3apa3HTeJIbHa.
I-1eCTb 3KCHepHMeHTaJIbHOrO aOKa3aTeJIuCTBa K0HTarH03HOCTH
LIyMbI co6aK HPHHaAJle}KHT E. 3eMMepy (1875), A. KpaeBCI{oMy
(1882), A. JlaypCOHy (1882), KOTOPble BHepl3ble B YCJIOBHHX KOHTpO
JIHpyeMOro ofbITa BOCHPOH3BeJIH LIyMy y Co6aK KaK HyTeM KOHTaKTa,
TaK H HpHBHBKaMH HOCOBOI-I CJIH3H co6aK, 60,IIbHbIX LIyMOII. DTHM OHH
0KOHVaTeJIb1IO HOATBepAHJIH 3apa3HTeJIbHOCTb II BbICOKVIO KOHTarHO3-
HOCTb '-IyMbI rIJIOTOSIAHbIX. Bo3HHl{Hlee OHIH60LIIIoe MHCHHe, LITO Kax{-
AaH co6ai{a o65I3aTeJIbHO AOJI?KHa Hepe6oJleTb 9y iofi (>)
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
(rycapeBHTI, 1918, Mlo.n.mep, 1928, n AP.), BcTpevaerc H B Hame
BpeMH.
OnbIT HOKa3aJI, WO B X035II3CTBa$ Aa}Ke c 6OJIbmHM KOJIHTIeCTBOM
)KHBOTHbIX, B KOTOpbIX CTporo BbIHOJIHHIOTCSI BeTepHHapHO-CaHHTap-
Hble HpaBHJla, TIYMa HJIOTOSIAHbIX He BO3HHKaeT B TeTieHHe MHorHX
JIeT.
COAep)KaHHe BHpyca TlyMbl B opraHaX 6OJIbHbIX )KHBOTHbIX
OCHOBHbIM HCTOTIHHKOM H pe3epByapOM BHpyca TIyMbI rIJIOTOSIA-
HbIX ABJIHeTC J 600bHOe )KHBOTHOe.
B nep1oA HHKy6aUHH, KJIHHHTIeCKOFO nepe6oJleBaHHH H peKOHBa-
JIeCUeHuHH )KHBOTHble pa3JIHTIHbIMH nyT5IMH BbIAeJHIIOT BHpyC BO
BHemHIoIo cpejy H TaKHM o6pa3oM HHCpHL(HpyIOT ee. BbIAeJIHIOT BH-
pyC H )KHBOTHble, nepeHOCHIUHe 3a6oJIeBaHHe B JIaTeHTHbIX, CTepTbIX,
a THHHTIHO npOTeKalow,HX, a60pTHBHbIX q)opMaX. 17aHTponHble CBOI3-
CTBa BHpyca TIyMbI IJIOTOIIAHbIX 06yCJJOBJIHBaROT ero JloxajTH3aUHIO
HOTITH BO BCeX TKaH$IX H opraHaX 6OJIbHbIX )KHBOTHbIX H HOTITH BO BCeX
ceKpeTax OpraHH3Ma, BbIAeJISHOHI,HXCSI BO BHeHIHIOJO Cpeljy (Ta6JI. 6).
Ta6JIHlja 6
CoAep caHHenBHpyCa 9yMbI HAOTOSIAHbIX B opraHax, ceKpeTax H
Ha3BaHHe
opraua HJIH
Bb1AeJ1eHHSI
CIpH Kamm ycnoBnllx, B TeYe-
HHe Kaxoro nepHOAa,
CTelleHb HH(JeICI(HOHHOCTH
HOCOBaa
CJIH3b
BanAHHrep (1819), )iena6ep-
6JIeH (1820),
H. JIyHHH (1836)
l'epTBHr (1840)
KaTT (1847), H. POAHOB
(1849), BeHyTa (1873), KoHxa-
y3ep (1874), E. M. 3eMMep
(1875), Tpac6o (1879)
A. A. KpaeBCKHH (1881)
(PpHA6eprep (1881), A. Jlayp-
COH (1882)
Kappe (1905)
Kpe KeHOB (1909)
H. F. 3HreH (1911)
JIekajoy H .IeHKHH (1926)
B. B. KOHICBON (1928),
EpHOH (1938),
I'pHH (1939)
F. C. TlepxacckHA (1948)
TIoCTenelHO cTaHOBHTCH 3a-
pa3H0N
He cojepxu1TC9
B TeveHHe HepBbiX 10 AHeii
6oJ1e3HH, H03)Ke oTCyTCTBI,eT
He Bceraa 3apa3Ha
2 Kamm 81,1361Ba}0T cMepTeJlb-
Hoe 3a6oneBanHe
help exgnoHHa B 20% c.RyvaeR
B IIepBble AHH 60JIe3HH
B Hagajie 3a6oJieBaHH2, HO
n03NCC He BCer, a
Y AHcnu
B rno9HSIX IIC Te4CHHAX CO-
Aep)KHTCH He BCerila
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ha3Ballne
opraHa 411113
BblleneHfl9
FIpn KaKnX yCJIOB119X, B Tegei
Hne KaKOI'O nepno1a,
cTenelib nn(peKUHOBnOCTH
i(oH'bK)nKTH-
BaJlbna9
C.1H3b
+:. 6I BO pOI Ka
KpOBH
'NOJIOKO
KpaeBCKnil (1882)
(Ppi )j6eprcp (1881),
Kappe (1905)
H. 1'. BNren (1911)
Bpnol (1938)
A. A. I:paeBCKnii (1881),
.ilaypcoH (1882),
Kappe (1905, 1924, 1927)
9(iren (1911)
H. H. THTOB (1912, 1913)
Jleilnnul: (1929)
B na'la e 6oJle311I1
He BCCr.'la 3apa3Ha
13 nepnble ;[in 6oaC3HH
Rpn nCpBOM IIOBhllICH1IH TCM-
nepaTypbl (nnor.lla n 6e3 Hee)
B 11030 0,01 MJI
B neplbl' ,mu 6o. C3111I
Bcerna B TC'eulle nepnox
2 Henenb 3a6oJIeBaHII9, H 30%
noCJIe 2 He;leJlb rI pcnKO 11031Ke
B nagaJle 3anoJIeBa111I9, 1103-
;K(2 110 BCerna
JL PajlaHlinJlJIOBC,oOi (1934)
Baprcl; . J. 11 M. (1934)
C. C. Ivu'r0B (1937)
POTTCJI b (1937)
Ipnll (193'3)
T. 51. BaHHOBCK01ii (1941)
LiepxaccunHH (1948, 1950, 1951
4P. 11. Opncli (1913)
POT'cCab (1937)
rlepxaccKHI+ (1948)
OpJIoB (1913)
Bunnllurroa n Ap. (193.9
PansnsnnnoBCI(IlM (1934),
BnlulpHx (1951)
ICOHx1V3.'p (1874)
Bo r,peMil nefiiOro Tcr,:uepa-
TypHOrO 11o1'hCMa
HH(~ eKgHO11HOCTb KpOB1 nc9e-
3aCT, Kor1a KOJI141CCTBO caxapa
H veMorao61111a nepeulal'Hyno
yepe3 I113H111ii IIpeACJ1
,U o 10-13 An9* 6wJi,3lin
Bcci-, a li nepIIOJ I. jBOIO
TCMnepa Typiior O 110 'L ' iPlI
Y nlici,
B Tpylulou Kpoli11 JuiC111k
Bo BpCM9 nepBO"O TeMnepa-
Ty1HO1O lloJl"bCV[a H He ncerJa
B Tpv'1IH011 ICpOlin
B nCp6!,IC iiil 6oJIe3Hn it W-'
Bccr,aa nocJle nanelKa
(Ony6:InI(OBauo B 1922 r.)
OTCYTCTBN-eT
1 1111 (~7CKIuIo na 1 nll~ia 11a
10 Tl.IC. apnTpoll1TOB
noCJle I'CMOnn3a
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ha3BaHHe
opraHa HJIH
BbiAeaeHHfl
IlpH KaKHX ycnoBHHx, B Teve
HHe KaKoro nepHoua,
CTeneHb HHfleKUHOHHOCTH
CJIH3b H3
TpaxeH H
6pOHxoB
CJIH3b H3 pTa
H CJIIOHa
11epexapAH-
aJlbHall )lKHJ(-
KOCTb
ilJIeBpaAb-
Ha)i x
(C. H. MypoMueB, 1948).
BowTbluOe 3HatIeHHe B TeqeHHe 3H300THIi LIyMbI HMeeT BHpyJIeHT-
HOCTb H allTiireHHblli THn BHpyca, Bbl3BaBHIero BCnbIIIIKy 6oJIe3IIH,
a TaIo+ce HMMyHOJIorHllecl{aSI CTpyKTypa }KHBOTHbIX KOHTHHreHTOB,
HOABep F(eHHbIX HH(JeKIIHH.
3HH300THH LIYMbI nJIOTOHIHbIX OTJIHLIaIOTCSi MaCCOBOCTbK) 3a6o-
JIeBaHIISi, npOTeKafonjero npH HOBbIHIeHHOl3 TeMnepaType TeJIa, KaTa-
pe BepXHHX AbIXaTeJIbHbIX HyTefi H rim. K 3TOMY HepeJKO npHCOe-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
RHHHIOTCH 6oJIe3HeHHbie HBJIeHHH CO CTOpOHbI KHIUegHHKa Ii JIerKNX,
a TaK?Ke paCCTpOHCTBa UeHTpaJIbHON HepBHOfi CHCTeMb'. OTMCRellbI
TaK)Ke 3nH300THH LIyMbI, npOTeKalonwe TOJIbKO HpH HBJIeHHHX JIHXO-
paaKH, 6e3 JlpyrlIX KJIHHHLIeCKIIX npH3naKOB (LlepKaCCKHI3, 1950).
D11300THR o6bIgHO JI,JIIITCH MaKCHMyM 1,5--2 Mec. ORHalco yCH-
JIeHHC BeTepHHapIlOrO Ha6Ju0aeHHH, CBOeBpeMeHHaH RHarnOCTHKa,
I1O )JIOBHaH e}Ke)wHeBHaH TepMOMeTpHH, H30JIHI(HH 60JIbHbIX B paHlle33
CTaJHII 3a6oJIeBaHHH H noR03pHTeJlbHbIX B 3apa)KCHHA IIapHJI,y c rip0-
BeJ[eHHeM JIege6HbIx H npo(JHJlaKTHu1eCKHX np11BI1BOK ,ioKaJIH3yeT,
coKpaluaeT H HepeRKO pe3KO o6pblBaeT IIa4aBIUylOdH BCnbIIHKy.
Moa HO OTMeTIITb l13BeCTHyIO CTaRHHHOCTb B pa3BHTHH TIyMHbIX
3I1300THH. HepBaH CTa i51-noHBJIeHtie H HapaCTaive 3a6oJieBBHH11,
BTOpaH-MaKCHMaJIbllbIH OXBaT 6oJIe3HbIO BCeX HJIH HOHTII BCeX BOC-
npH14M7IHBbIX }KHBOTHbIX, TpeTbH-nOCTeneHHOe yracaliHe H noJIHoe
IlpeKpaIljenHe 6o.Ie3HH, eCJIH B Xo351NCTBe II(,T nepMaHeHTHO nOR-
paCTalOIUero HeHMMyHFIOrO K tiyMe MOJlO)lFIBKa n.IH He noeTynalOT
HeHMMyHHbie KOHTHHreHTbl >KHBOTHbIX H3BHe. B 11pOTHBHOM cjiyilae
noc ie H3BeCTHOH CTa6HJIH3auHH B03MOA{eH Hel.OTOpblu HOBbIII nORb-
eM H RJIHTeJ]bHoe, KaK 6b1 TetIeHne 3I1300THH. HaKO-
lieU, MOryT 6biTb peUHAIIBbI Upll nOr1aaaHHH B X03HIdCTBO HOBOI'O aJ1H
Hero TIIna HJIH pa3HOBHRHOCTH BHpyca HyMbl HJIOTOHRHbIX. B TaKHX
CJlyHaHX BHJIOe TetICHHe 3H300THH yKa3blBaeT na
XapaKTep HH(JeKUHH.
Heno.nHOUeHHOe KOpMJIeHFle, iIJIoxlle yCJIOBHH coAep)KaHHH H
yxoAa H apyrne cJaKTOpb1, cHHACalolune ecTecTBennylo yCTOHIIHBOCTb
>KHBOTHbIX K HFI(peKUHH, CUOCO6CTBYIOT pa3BHTIIIO 3H300THII.
CKOpoCTb Te~IeHHH H 6JIaROllpllHTilbl1'I HC:OJ 3H300THH 3aBHCH1'
OT caHHTapHO-rHrHeHHHeCKHX yCJIOBHII Coaepa{aFHH H KOpMJIeHHH,
CBoeBpeMeHHOCTH H FlOJIHOTbI H30JIHUHH 60JIbHbIX, B TOM iIHCJIe TeM-
IlepaTypHIUHX }KHBOTFIbIX, TwaTCJIbHOCTH npOBeaeHHH ae3Hll(~ eKUHli
H RpyrHX BeTCpHHapuo-caHHTapHblx H HpOTHBO3fH30OTHHeCKHX
MepOnpH11TIIR.
O6Hapy}Kellne nepBOIICTOHIIHKa 311300TH11, VCTallOBJIelIHe n npe-
ce,IeHHe KaHaJIOB nOCTynJleHHH HH(peKlllnl B X03B1iCTBO BBJIHIOTCH
ORHOH H3 OCIIOBHbIX 3aaaH BeTepmnapHOro Bpa,ia.
3H300TnH HFyMbl rlJIOTOHRHbIX npOTeKalOT B pa3Jlu'IHbIX reol'pa(j)H-
IICCKHX 30HaX CCCP B OCHOBHOM no ORIIOMY H TOMy }Ke THny (uCp-
KaCCKHU,1954).
CBoeo6pa3HOe TetlenHe LIyMbI y HjeHKOB pca.HHelO Bo3paCTa HHor, a
HaKJIaJbIBaeT FI3BeCTHbIi OTnegaTOK lid Teueolie 3H300THI,1.
HHOrRa 3H300THH ilyMbl UJIOTOH)HbIX IIMCIOT TeHaeHUHIO B CTaUllo-
IIapHOCTH, HeKOTOpble aBTOpbl yKa3bIBa}OT Ha aJIHTeJlbHoe (KXpOHH-
1IeCKOC>) Te'IeHHe tlyMbl B 3BepOX0351KCTBaX; HMCIOTCB TOK}KC (kaKrbl
nepnoaHBeciwro nOBTOpeHHB BCHbluiek 6oJIe3H14 H aJIIITeJIblloro Ce
TcgeHHH B IIHTOMHHKaX co6aK, He6JIarOII0JIyHHbIX no UyMe, Kyaa 3a-
IiOC HHc)eKUHH qepe3 BHOBb noCTynaFon nx co6aK HCKJTIO9eH. 7 aK,
nanpiMep, 6o.nee 10 .neT TIyMa 6bFJIa cTaLHOHapxa B oaHOHI HIKOJIe
c.o6aKOBOJCTBa, pacnOJFO}KCHHOH B qettT'pa,tbHoIi no:loce CCCP.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Oco6eHHO 3JIOKatIeCTBeHHO 3H300THH npoTeKaJia 3HMOI-I, paHHelri
BeCHOFi H r.Iy6oKOH oceHblo, BbI3bIBaH e}KerOjjHO rn6eJlb Ao 20-25%
MOJIOJjHSIKa-OTbeMbIHIeu H 6OJIbIHOH OTXOA B3POCJIbIX co6aK.
B apyror IIIKOJIe, paclloJloaceHH0H B TOR )KC 3OHe, rAe COCTMB
co6aK McHSIeTCH Ka}KAble 3-4 McCH a, tlyMa 6bIJIa CTauHOHapHOH
IIOIITH BCC BpeM I. 3Aecb B 1949 F. 3a6oJIeJio 51,3% H nano 20,7%, a
B 1950 r.-cOOTBeTCTBeHHO 51,4% H 10,9% Bcero cocTaBa co6aK.
B Hixane, pacnoJloxcennoR B ceeepo-3anadn0u 3one, rjje KOHTHH-
reHT co6aK 6o iee nOCTOHHHbIH, McHSI1oHjHHC5I pa3 B FOR, H co6CTBeH-
HbIX IueHKOB Majio, tlyMa peruCTpnpOBaJlaCb ceMb JieT noJjpxjj. B
1948 r. B HeR 3a6aneJlo 67% H nano 20% B3pOCJIbIX co6aK H COOT-
BeTCTBeHHO 100% H 51 % HjeHKOB.
B riKOJIe, pacnoJlo}KeHIIof 8 3anaO-06 30He, B TeT-IeHHe p5ijja JIeT
3a6OJIeBaHlje co6aK iIyMOR COCTaBHJIO Ao 75?/? BceR cTaw-OnapHOH
3a6oJleBaeMOCTH, a CMepTHOCTb OT 4yMbl-6O% Burl CMepTHOCTH
co6aK 3a 3TH rOAbI.
AHaJIorH'IHaR KapTHHa OTMe ieHa B IIIKOJIaX, pacnoJ10}KeHHbIX B
KOoICnoa 11 toao-3anadnbtx 30Hax CCCP.
Ho AaHHbIM H. MHpoJlio6OBa (1932), 3H300THH LIyMbI y eHOTO-
BHAHbIX co6aK, HaXOASiMHXCH B HeBOJIC, npOJ oJI?KaIOTCH AOBOJIbHO
,1 JIHTeJlbHb1H CpoK, CBbIHIe 4 McCHUeB. 143 184 eHOTOBHAHbIX co6aK
3a6oJle.no H nano B Aexa6jpe 19, B HHBape-47 n (~eBpa.ne-54 ro.noBbi.
3a nocJlejjHee BpeMSI OTMetIeHbl MHorHe cjiytlau IIOBTOpHOI'0 3a6o-
JIOBaHHH co6aK tiyMOR.
CTaTIICTHKa 3a60JIeBaHHR co6aK 'IyMOH 3HagHTeJIbHO npeyMeHb-
HIeHa TaK)Ke 13 nOTOMY, 'ITO nOBTOPHble 3a60JIeBaHHcI uaLue Bcero
KJIHHnL1eCKH npOTeKaIOT HeCKOJIbKO McHee THnHgHO H npOXOJ HT MR
JIpyrHMH J!narHO3aMH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B0306HOBHJIacb c npe%Heii CnJIOH C HaCTyH1ICH13eM Mopo3oB. TaK)i(e
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
KOTOpac AaeT XapaKTepHble 2-3 B3JIeTa, 06b1'IHO o&b}ICHHeMble
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Mapexa, Mannunrepa it Mo'iii (1954), y 50% H j axKe y 751/o nyMHbix
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r.IaBIIbIM O6pa3OM B HepBHbIX KJIeTKaX rOJIOBHOI'O H CUHHHOFO M03ra.
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A. KyTefOBa (1955) onHCa.na OKCH(pHJIbHhie Te.nbua BKJFIOTIeHHSI
Hp1I gytiie HJTOTOSTJJHbIX y eHOTOBHJHbIX co6aK. 0HH ga!ue Bcemo Kpyr-
3011 HJIII Of>aJIbHOH (IOpMbI, 06b1 HO 6eCCTpyKTypHbl H BCT;pegaIOTCH
(CT 1 jlo 15) UFIT0nJIa3MaTHMeCKH, pe}Ke BHyTpHHjlepHO B 3nHTeJIHaJIb-
Ho4I u erue pee B coejjFHHTeJIbHOF3 TKaHH, rJIaBHbIM o6pa3OM KHuJeiI-
IIFHCa, JICFKHX, HegeHH, MOgeBOrO Hy3blp9, >KCJIyJKa H 6pblxceCIIHb1X
nilM(1)aTHgeCKHX KeJIe3.
IlaprJy C IIpIIBCJIeHHbIMH JaHHbIMH 0 IIBJIHMHH CneuH(JHgeCKHX
TeJICI[ BKJIIOUCIIHST HpH gyMe HJIOTOHJHbIX, HMCIOTCH j[aHHble ITpOTHBO-
nOJIO>KliOro XapaKTepa.
TaK, HpH rIlCTOJIOFHMCCKHX HccJIeJOBaHHnX rOJIOBHOTO MO3ra CO-
6aK H XopbKOB, naBIHHX OT gyMbl, JlefjtJloy H UeHKHH HH pa3y HX
He oUHCaJIH.
BK.n1OgeHH1 HpH CaMbIX pa3JIHTIHbIX Cnoco ax OKpaCKH He 06Ha-
py>KH.nH TaK>Ke PaMOH H JIann (1924), KJiHu, l a.nero, [IocpeJHHK,
fIyCTCJIbI]HK (1934) H JpyrHe aBTOpbl. Y>Ke BaCKHHH (1931), q)1'7H-
jl,ncf (1938), 1-I. (1). FaMa.nenn (1939) yxa3aJIH, TITO npnpoJa BHyTpH-
KJIeTOIHbIX BKJTIo-IeHn11 H HX CIIeuHC!HgHOCTb,[JIST gyMbl riJIOTOHJHbIX-
HeHCHbi.
Max HHTaup H Jpyrne (1948), Popep (1951), fIoTeJIb (1951),
BHFIIpHX (1951) He MOrJIH O6Hapy}KHTb TCJIbua BKJTIOTIeHH51 Ja>Ke
VPH HaJIHgHH B HeipBHbIX KJIeTKaX M03ra rHCTOJIorH ieCKHX H3MeHeHHI-I,
XapaKTepHbIX AJIS1 TIyMbI.
HepejjKO uHTOnJIa3MaTHHeCKHe BKJIIOgeHHSI B 3nHTeJIHH 6pOHXOB,
CJIH3HCTOFf HOCa, B MOgeBOM ny3blpe H Ap. 06Hapy}KnBaJInCb y co6aK,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
iie 6OJIeBLuHX TIyMOH, H He o6Hapyx{HBaJIHCb y 6oJIbHbIX (HHHec,
1949).
HTaK HMeeTCSI MHOro pa3HOO6pa3HbIX CpaKTH4eCKHX JjaHHbIX H
B3FJIfJZOB B OTHOIIIeHHH XapaKTepa, npHpoabi H pacnpejleJIeHHA TeJIeu
BKJIIOUeHH1 B 3KCnepHM HTaJIbHbIX H eCTeCTBeHHbIX cJlyLIaHX 1-IyMbI
nJIOTOHAHbIX y cO6aK, JIHCHL, HO,pOK, yCCypHHCKHx eHOTOB, HO Heo6-
XOJjHMO npH3HaTb, YTO KJIeTOLIHble BKJIIO4eHHH npH 4yMe rIJIOTOHJIHbIX
Bce ewe OTHOCHTCST, KaK yKa3bIBaJI FaMaJIeH, K qHCJIy COMHHTeJIbHbIX
H MaJIOH3y9eHHbIX, a Te BKJIIOYeHHH, KOTOpb1e H3ygaJIHCb, J(aJIeKO He
Bcer,aa naTOrHOMOHHT4HbI.
HeO6XOJIHMbl aaAbHeHuime HccJIeAOBaHHH, KOTOpble BHeCJIH 6bI
3ICHOCTb B TOT Ba)KHbIH BOnpOC.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
FJIABA J ECWTAfI
ZLAHHbIE 110 EIAT0 EHE3Y MYMb1 IIJIOTOSIljHbIX
O MEXAHH3ME HH(bEKLLHOHHOFO HPOLECCA H TPOIIHOCTH
IHPYCA MYMbI HJIOTOSIL1HbIX
HaToreHe3 4j'MbI HJIOTOSIJjHbIX H3ytIeH He,i OCTaTOtIHO,
CoBpeMeIIHaI HaTOJIorHSI H KJIHHHKa, OCHOBbIBaloruHeCB Ha HO-
cJIeJjOBaTeJibHO-MaTepHaJIHCTH4eCKOM ygeHHH H. FT. HaBJIOBa, H. M.
Ce4eHoBa H C. 11. BOTKHHa, yKa3bIBalOT Ha OHpejjennRForuylo pOJIb
FrepBIIO.I CHCTeMbI B BO3HHKHOBeHHH, pa3BHTFIH H HcxoJje Tuo6oro
HaTOJIOPH4eCKOr'O Hpoueeca, B TOM 4HCJre Bb1313aimoro CHeuHC1H4eCKHM
RO36yjjHTeJIeM.
be3 BHpyCa 4yMbI HJIOTOHjI,HbIX KaK cneuHClH4eCKOrO Bo36yJjHTeJI5i
H 4pe3BUI4a6HOI'O pa3Jjpa3KHTe.IH He MO}KeT 1303HHKHyTb TBKOI%I HaTO-
JIorH4ecKFIn HpOUeCC, KaK 4yMa HJIOTORJJHbIX. OjjHaKo POJIb BHpyCa
B Te4eFIHH 6OJIe3HH He HBJIAeTCH FCKJIIOgHTeJIbHOn TaK KaK KHpOUecc
B036y}KJLCHHH ... Bb13BaHHhIf1 B HepBHOI3 KJIeTKe, OCTaeTCH B Hen OTICHh
,ROJIro: MHHVTbI, 4aCbI, J HH, a TO H rOJjbIN (I/I. H. HaBJIOB)
Taxi, Ha IIepBbin HJIaII rlpH TaK Ha3bIBaeMbIX
FI pBHb?X 0CJIOiKileI1HAX BbIJjBHraIOTCR (j)yHKUHOHaJIbHble HJI1 MOpCj.)O-
.1o144eCKHe 1I3MeHeHH2, XOTSI H Bh13BaHIIbI0 BHpYCOM, HO 3aTeM HpH-
o6peTaB11IHe 3HageHHe CaMOCTOHTeJIbHbIX pa3,lpa)KHTeJIeII HepBHO-
pc(1).;IeKTOpHOrO MexaHH3Ma. N. H. HaBJIOB HHCajI: KeHHSI 6o-
JIe311II H XapaKTep113yeTC2 Bblpa)K FIHOCTbIO 3aMHTHbIX peaKUHH
opraIIn3Ma. I'IIH1)eKuH0HI-IbIII H HMMyHOJIOFH4eCKHI npogecc HJyT
1)51RONI II COCTaBJ15IIOT eJ>;WHOC ueJIOe. OCTpble SIBJIeIIHSI -- BbICOKaH
TeMnepaTypa H T. ,I.-o6bI4HO HC4e3alOT 4epe3 10-I5 ,I[HeilH K
3TOMy BpeMCHn B Op('aHn3Me Bblpa6aTblBaeTC5I HanpmiF eHIIhIH HMMy-
IInTeT. B o6pa3OBalJIIn erO Ba3KHy1O pOJIb HrpaeT ueHTpaJnbHaH
II^puuaH CHCTeMa.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JLHArHOCTHKA 4YMbI HJIOTOAAHbIX
,HarHOCTHKa t1yMbI nJIOTOSIaHbIX OCHOBbIBaeTC51 Ha KOMnJICKCe
KJIHHHKO-3nH300TOJIorJIYeCKHX, naTOJIoro-aHaTOMHgeCKHX H 3THOJIO-
rngeCKHX J(aHHbIX, nOJiytleHHbIX npH HOMOLuH pa3Hoo6pa3HbIX, B TONI
tiHCJIe JIa6opaTOpHbIX McTOJLOB HccJIe,i[oBaHHSI.
KJIHHHKO-3HH300TOJIOCHgECKHH H IIATOJIo O-AHATOMHgECKHH
)jHArHO3 4YMbI IIJIOTOSIAHbIX
Ellie Kappe (1905) noJjtlepKHyJI, tiTO npH tiyMe co6aK He HMeeTCH
HHKaKOI'O KOHCTaHTHOI'O cHMHTOMa. JZeACTBHTeJIbHO, KJIHHHKY H TetIe-
HHe, BeCbMa noxo?KHe Ha tiyMy, MOMKHO Ha6JIIOJjaTb npH MHOrHX
JtpyrHx HHCpeKUHOHHbIX 3a6oJIeBaHHHx co6aK H nynlHbIX 3Bepec H
HapyHJeHHHX aJIHMeHTapHOro nop5 Ka.
K HaH6oJiee THnH'IHbIM CHMHTOMaM, J[aIOHjHM OCHOBaHHe JLJIH
KJIHHH4eCKOPO allarH03a t1yMbI, B nepsyIO otlepe,L b OTHOCI-ITCH nOBbI-
HIeHHafI TeMnepaTypa.
Kappe elue B 1905 r. oTMegaji, 'ITO .
B JLaJIbHeiinleM fOtITH Bce HCCJIeJ oBaTeJIH npHXOJJSIT K BbIBOJ[y,
4TO TeMnepaTypHbII3 CHMHTOM 9BJI5ieTCH Han60Jiee BepHbIM, a HHOrga
m eAHHCTBeHHbIM KpHTepHeM ,L JIH AHarHOCTHKH tlyMbI fJIOTOHJjHbIX.
JZJIH tiyMbl y co6aK HaH60Jiee THnH4Ha IByXBepxyiue4Ha 1 KpHBaH.
TaK, B onbiTax BHH,apHxa (1950) y 124 co6aK (143 148) nepBbii3
noJ('beM TeMnepaTypbl OTMetieH tiepe3 3-5 gHeI3 nociie 3apaMKeHHH,
a BTOpOFi - tiepe3 3-5 gHef nocJie nepBOro. B 2 % cJlytlaea B 6OJiee
n03,L Heh CTaJiHH t1yMbI OTMe4eHbl 3 H 4 noJL'beMa TeMnepaTypbl.
CorJIacHO 3KCnepnMeHTaJIbHbIM AaHHbIM Uperepa H LUaHJ[Jlepa
(1951), CMeuiaHHylo HHq)eKUHIO y 9yMHbIX CO6aK CJIe1[yeT fOJjO3pe-
BaTb B Tex cJlygaHX, KOrAa nepabll'i nO, 'beM TeMnepaTypbl npeBbuhIaeT
41,0? H eCJIH BTOpntIHbI noq'beM TeMnepaTypbl , OcTHraeT ypoBHH
nepsHgHoro.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MoorIIe aBTOpbI paccMaTpHBaIOT UyCTyJIe3HylO 3K3aHTeMy KaK.
Ba}KHbIu IHarHOCTH'IeCKHu HpH3HaK.
OJHaKO 6oJIbLUHHCTBO HCcJIeaOBaTeJIeI3 OTpHU,aIOT HaTOrHOMOHH'L-
IIOCTh KO)KHbIX HyCTyJI, KOTOipble BOBCe OTCyTCTByIOT HpH 'IyMe
y JI11CHLI? IIOpOK, eHOTOBHJHbIX co6aK H BOJIKOB.
HCTCUCHHIO H3 HOCa LI rJIa3 B HpaKTIIKe o6bhIHO HpHaacTCA pe-
IUaloLuee 3Ha9eHHe ajio anaFH03a 'IyMbI. OJHaKO y}Ke OHreH o6paTHJI
BHIIMaHHe Ha TO, 'ITO p1HHT 11 KOH'bIOHKTHBHT HpH 'yMe y co6aK
Hepeaxo Bblpa)Kexbi o'iexb c.na6o, a (Deppn (1912) C'IHTaeT 3TH
CIIMHTOMbI pe3yJIbTaTOM BTOpHHHOYI HH(IJeKLIHH. OH cnpaBeJJIHBO yKa-
3bIBaeT, 'ITO 'lyMa y co6aK H HyLUHbIX 3Bepei MO}KCT HpOTeKaTb 6e3
3THX AB.neHHI-T, 0006eHH0 B HepBble uHH 6oJIe3HH. DTH Ha6JIIoJ eHHS1
CorJiaCyIOTCA C yTBep}KJjeHHeM Kappe H MHOrHX Jpyrmx aBTOpOB
0 TOM, 'ITO eI(HHCTBeHHbIM CHMHTOMOM 'LyMbl UJIOTO9J1,HbIX IlepeJLKO
ABJIHeTCA TOJIbKO BbICOKao TeMHepaTypa TeJIa.. TaK, 1-IaaJ0K (1947)
yKa3aJl, 'ITO Ha6JiloaaeMble y co6aK H JILICHIl, rHOIIHble BbIaeJIeHHA H3
rJIa3 H Hoca KMO}KHO Ha6JIK)JaTb He TOJIbKO HpH ?IyMe, HO TaK}Ke HpH
HHeBMOHHAX, CTpeHTOKOKKOBbIX HLI(peKI1,14AX, HapaTHcpax, 3HLje(lJaJIHTe.
H apyrux 6OJie3HAX> .
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J1JI5T 'IVMb[. HaJIli4I e HJIH OTCyTCTBHe KaLUJ[A Y }KHBOTHbIX UOMOraeT
onpeaeJlHTb, HMCeTCA JIH HOpa}KeHHe BepXHI,[X JbIXaTeJIbHhIX HyTeli,
JIerkox H 6pOHXOB. KaLHeJIb y 6oJIblb!X co6aK .nerKO BbI3BaTb UepKyC-
CHeFl H CJaHJIHBaHHeM rpyJHOH KJIeTKH, Ha)K:HMOM Ha rOpTaHb. Ka-
UleJlb, COUpOBO}KJaeMbin pa3JyBaHHeM u eK, xapaKTeper JJIA BOCLIa-
JICHHA JIerKHx, a Bb1U5i'IHBaHHe pe6epllblx IIpoMe}KyTKOB, 6oJIb H
KamIeJIb UpH HaaaBJIHBaHHH - JJIH HJIeBpHTa.
Y co6aic, B OTJIH'IHe OT apyrHX }KHBOTHb]X, 'IaLUe BcerO Ha6JIIo-
JJaeTCA pe6epHblc THU abIxaHHH. HopMaJlbHoe 6pOHXHaJIbHOe Jblxa-
HHe, KOTOpOC IlpeKpaCHO HpOCJIyLLIHBaeTCH y CO6aK B o6JIaCTII JiQUa-
TO'IHO-HJle1ie3orO mica, HpH 'IyMHbIX 6pOHXOIIHeBMOHHAX, CBA3amiux
C 60JIbHJHMH HHCIHJIbTpaTaMH, CTaHOBHTCH TO rpOMKHM H CHJIbHbIM,
TO BOBCe HC'Ie3aeT. HeKOTOpble aBTOpbI C'LHTaIOT, 'ITO TaK Ha3blBae-
Mb113 ,a. (K. Mauy.neBH',
1883, K. boJlb, 1892).
HO Pyire (1949), JJIA aHarHOCTHKH paH:HHX CTaJLHH 'IyMbI Y CO-
6aK Ba}KHOe 3Ha'IeHHe HMeeT TaK}Ke TaK Ha3bIBaeMbll-1 , JierKO o6Hapy}KHBaeMbll3 UpH HaaaBJIHBaHHH pyKON. OaHa-
KO pH4 aBTOPOB OTMe'IaJL, YTO HOACHH'IHbIFI H (PeMOpaJIbHbI13 pe()JIeK-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
,CbI Ha6JIIoAa}OTCH y MHOrHX 3AOpOBbIX co6aK H OTCYTCTBYIOT Y MHOrHX
6OJIbHbIX.
BHUHrMaHH (1937) npH,i aeT 60JIbHIOe 3HaqeHHe AJIH paHHero
JJHarH03a qYMbI y co6aK TOH3HJIHTy, CBH3aHHOMY C aHrHHOR, cpapHH-
:rHTy, OTHTY H BarHHHTy.
PHA aBTOpOB npe,gJlaraeT OCHOBbIBaTbCH npH aHarH03e Ha COBO-
KYHHOCTH HeCKOJIbKHX KJIHHHT1eCKHX CHMIITOMOB. TaK, no H. Xo.nMaH-
,CKHX (1913), OCHOBaHHeM Aim AHarHO3a TIYMbI HBJIHIOTCH KaTapaJIb-
Hble H HgPBHble HBJIeHHH HJIH KaTapaJlbHble HBJIeHHH H nyCTyJIe3HaH
Cbinb, no MaKapeBCKOMY-COBOKynHOCTb KO}KHOII CbIHH, PHHHTa H
KOH'bIOHKTHBHTa npH BbICOKOii TeMnepaType. [lo KHyp-MypaTOBy
(1948, 1952), AAaMaHHcy (1950), OCHOBaHHeM AJIH aHarH03a 4IYMbI
>cJiy)KaT KaTap AbIXaTeJIbHbIX nyTex H KHHIe4HHKa, JIHxopaAKa, HepB-
Hble CHMHTOMbI H KOHTarH03HOCTb, 1-1pH BTOM KHyp-MypaTOB yKa-
3bIBaeT, LITO OTCYTCTBHe HePBHbIX CHMHTOMOB npH HaJIH4HH Bcex
ApyrHX ,geJIaeT AHarHO3 TOJIbKO BepOHTHbIM, HaJIHgHe JIHH1b KaTapa
AbIXaTeJIbHbIX nyTei3 HJIH KHHIe4HHKa TeM 6o.nee He AaeT OCHOBaHHH
1[JIH AHarH03a, KHBOTHbIX, naBIIIHX OT LIyMbI.
,1JI5I BHpyCOJIOrMHeCKOrO HCCJIeIOBBHHB 6epyT aCenTH9eCKH F13
v. femoralis a y He60JIbmHX FIOJOnbITIIbIX njeHKOB HyTeM cep,rI,eTIHOIH
(4yHKgliH (B 5-M Mexcpe6epxoM npoMe}KyTKe, rJe Han16oJIee HHTCII-
CHBHO Bblpax(eFI cepjjeFnbIYI TOJhIOK) 2-3 MIT KPOBH B o6hIHHylo CTe-
pHJIbHyIO 6aKTepHoJlorHHeCKylo npo6Hpxy, cojIepxcanjylo 0,2-0,3 MJI
10% paCTBopa JIHMOHHO-KHCJIOro HJIH IuaBeJIeBO-KFICJIOrO HaTpml.
B cjiy'-Iae HeB03M0>KHOCTH IIjHTpHpOBaTb KPOBb ee ae(THHi46pHHHpYIOT
HYTCM MHOFOKpaTHOI'o BCTPIIXIIBaHH5I npo6HpKH.
HOCOByIO CJIH3b H BbIJjeJIeimH H3 rJIa3 C06HpalOT Ha CTepHJlbHbIIi
BBTHbIFI TaMnOHgllK H noMenjalOT B CTepHJIbH`0O npO6HpKy.
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noro HJIH CnHllIloro) no eIIjaiOT B 50% BOJIHblli rJIHII,epHH, a B XOJIOJ[-
Hoe BPCMH rOJja 3aMOpa)KHBaIOT.
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C.TIH3b10, Bbljjejlel-IHIIMH 113 rJIa3, Kyco'-IKaMii HapeHXHMaTO3HhIX opra-
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3aJIITBaFOT lIapa(l)HHOM HJIH CMOJIKOH H nONIM'81OT B McTaJIJIIhIeCKyIO
6aHKy HJIH neHalI C BJ1OTHO 3aKpbIBa1ow.eliCTI KpbIHIKOIi. UlIO H CTeHKH
6anKH (nelfaAa) o6KJIaJIbIBaIOT BaTOH. MaTepHail AOCTaBJIHIOT B JIa-
6opaTOpHlo C H0POIlllbIP,I B HaH6oilee KOPOTKHI1 cpoK. Hpu 6O,-iee
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,jOCTaBKa MaTCPHaJIa B TePMOCC CO JIbIOM.
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HaTOJlorMHeCKHu MaTepnaJI npeABapHTeJlbuO pa3BOXiT RHCTHJIJIH-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
pOBaHHON BOJOII HJIH pa3MeJIbLialoT nyTeM BCTpSIXHBaHHSi BO CpJ1aKo-
HaX CO CTeKJISIHHbIMH 6ycaMH. ;IJIH pa3BeAeHHFi BMeCTO BHpyJIHuHJI,-
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FI ITb CyTOK. TIa.IHYHe BHpyCa LIyMbI nJIOTORJIHbIX B CJHJIbTpaTe (a npH
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,'jo3e 4 MJI BBOJIHTCS1 rmaK0)KHO H BHyTpHMblmegHO 2 OnbITHbIM )KH-
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3 HeJjeJlb. TIpH H:3JIHLIHH B HCCJIeJjyeMOM MaTepraJie BHpyCa OnblTHbie
)KHBOTHbie o6bILIHO Ha 5-7 JIeHb 3a60JIeBaIOT IlyMOII.
BHpyc, BbIJjeJIeHHbIIi OT 3a6oJIeBHIHX )KHBOTHbIX, HJIeHTHCIHUH,
pyeTCSi Ha OCHOBaHHH COBna1jaloLuHX pe3yJIbTaTOB 611onpo6bl H cepo-
TIorHL1eCKHX HCCJIeJIOBaHHfl (peaKUHSI HeliTpaJIH3aUHH, peaKIHH 3a-
JlepxcKH reMoarrJIIOTHHauHH H AP.). ,JIH peTpocneKTHBHOI-I JIHarHO-
CTHKH JIOJIro JIe}KaBIIIHX TpyfOB JjHKHX HJIOTOH,L HbIX )KHBOTHb1X ueJie-
coo6jpa3HO HCCJIelIOBaHHe KOCTHOI'o M03ra Tpy6LlaTbIX KOCTeI-i, TaK
KaK, n0 aaHHbIM BHTTOV (1940), I-Tepxaccxoro (1952), BHpyC IIyMbI
IIJIOTOHJIHbIX B HHX COXpaHHeTCH CpaBHHTeJIbHO aojiro. PeKOMeHJjye-
Moe HCnOJIb3OBBHHe JjJISI HHarHOCTHKH 3apa}KeHHe OJIHOMeCHLIHbIX
KOTHT BecoM 300-500 r (B. TIaHKOB, 1950, C. JIio6arueuxo, 1954)
nyl'eM BBegeHHSI 12 MJI 10% cycneH3HH naTOJIorHLleCKoro Ma-
TepHaJia BbI3bIBaeT COMHeHHe, TaK KaK KOIlIKH LIyMOI3 nJI0TO5IJjHbIX lie
60JIeloT.
3apa)KeHHe KypHHbIX 9M6pHOHOB
TICC.rie,ayeMbll{ q)HJIbTpaT (HJIH He(kHJIbTpOBaHHbIfI paCTBOjp, coJIep-
KaLuH13 neHHUHJI., HH) HHOKyJIHpyIOT B XOpHaJIJIaHTHOCHyIO 060JIOIIKy
He McHee LIeM 5-7 KypHHbIX 3M6PHOHOB, o6JlaaaioiuHx xopoiuefl no-
jBH)KHOCTbIO, B BO3paCTe 7-8 JIHex. aJISI KOHTPOJI51 BBOJISIT HO 0,1 MJI
C3 H3HOJIorHLIeCKoro pacTBopa JIByM KYPHHbIM 3M6pHOHaM. TeXHHKa
IIHOKYJI3IUH14 COCTOHT B cJIeJIy1oweM. 5THuo nOMeuialQT _B nOJICTaPI;\
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BBepX nyroH, CKO JIyny 1Hua npOTHpa1OT BaTHbIM TaMIIOHLIHKOM,
CMO4eHHbIM CrIH;pTOM H CpJIaM6HpyIOT. 3aTeM CTepHJIbHbIMH HO}KHH-
uaMH yaaJIHIOT y4aCTOK CKOpJlynbl H FIOACKOpJIyfHOH 06OJIO4KH Ha
BCCM npoTH?KeHHH TynOrO KOHua HHua. HpH ropHHxeM cnHpTOBOM
CJaKeJle Ha o6Ha}KeHHyFO x0pIOaJIJIaHTOFICHYH) o6oJIO'Ky Ka}KJIOrO Ky-
pHHOI'O 3M6pHOHa HaHOCHT 0,1 MJI HHOKyJIHTa, OTBepCTHe 3aKpbIBaIOT
CTepuJIbHbIM 4aCOBbIM HJIH nOKpOBHbIM CTeKJIOM, KOTOpoe npHKJICFI-
BaIOT CTCpHJIbHbIM paCnJIaBJ1eHHbIM napaq)HHOM HJIH JIeHKorIJIaCTOf.:,
H HHuo noMeluahOT B TepMOCTaT (37,5x). HepByIO OBOCKOHHIO npon3-
BOA2T B 3aTeMFIeHHOM 60Kce 'Iepe3 18 qac.
0 }KFIBbIX KypHHbIX 3M6pHoHax CyAHT no HX LIOABH}KHOCTH npH
,OBOCKOnHII. llorn6luue KypHHble 3M6pHOHbI, Hao6opOT, HenOABu)KHbI
11 BOKpyr HHX 06pa3yeTCH XOpOLHO o1ep4eHHblfl KOHTYP COCyAOB, Ha-
nOJIHeHHbIX KpOBbIO. FH6eJIb 9M6pHOHOB B CPOK AO 18 4aCOB 06bI'HO
o6yCJlOBJICHa TpaBMaMH, 6aKTepHaJlbHbIM 3arpM3HeHFIeM H ApyrHMH
npn4HHaMH. OT BHpyCa 4yMbI nJIOTOHAHbIX KypHHble 9M6pHOHb1
norH6aiOT 4epe3 18 H 6oJlee 4aCOB. OHH rHnepeMHpOBaHbI, TeJIO FIX
yceHHO MHO}KeCT3eHHbIMH TOLIe4HbIMH 3KCTpaBa3aTaMH, neTeXHSIMH,
o6wHpHbIMH reMopparuuMH, ocoOeHHO B 06JIacTH rOJIOBbI. O4eHb
xapaKTepHO ynJIOTHeHHe xopuoaJIJIaHTOHCHOH 06oJI04KH H o6pa3OBa-
HHe Ha Hei3 15-35 CpOKyCHbIX nopaxceHHH, npeACTaBJIHIOUIHX co60H
McJIKHe, C npOCSIHOe 3epHO, HJIH 6oJlee KpynHble H MyTHble o6pa30-
BaHH51 C paCnJIbIB4aTbIMH KpaHMH.
(POKyCHb1C nopa}KeHHH nOACgHTbIBaK)T C rOMOLUbIO py4HOH Jlynbl
HJIH npH Ma.IoM yBeJIH4eHHH 6HHOKyJIHpHOrO MHKpOCKOna, noMeul;aH
xopuoaJiJIaHTOHCHyIO o60JIOLIKy, npoMbITybo 10% paCTBOpOM (~opMa-
JIHHa Ha CTeKJIO C 4epHbIM 4)OHOM.
113 norH6LUHX 3M6pFOHOB npOH3BOAHT BbIceBbI Ha MIIB, MHA
pH=7,2-7,4. ECJIH KypHHble 3M6pHolibI nOrH6JIH OT BHpyCa 4yMbI
nJIOTO9AHb1X --BbICeBbI AOJI}KIibi 6bITb CBO6OAHbIMH OT MHKpOCJJIOpbI.
FH6eJlb Ao 60-75% HHOxyJIHpOBaHHbIX KypHHbIX 9M6pHOH0B HJIH
HajiHque XapaKTepHbIX H3MCHeHHH Ha xopHOaJIJIaHTOHCHOH o60JI04KC
Bb1}KHBLLIHX 3M6pUGHOB, KOTOpble aOJI}KHbI 6b1Tb BCKpbITbI Ha 5-6
JJ,ellb nociie 3apa}KeHHH, HBJIHeTCH nOKa3aTeJIeM HaJIH'HH BHpyCa.
OJ1HaKO HaAO HMe.Tb B BHAy, TO BeCHOI3 H JIeTOM KypHHble 3M6pHOHbl
norn6abOT OT BHpyCa 4yMbI rIJIOTOH,AHbIX 'pe}Ke, He}KeJIH 3HMOH H
oceHbIO,
METOp,bI CEPOJIorHgECKOr1 AHArHOCTHKH
PeaxuHSi HeHTpaJIH3aILHH
HCCJIeIIOBaHHH Olirella (1912), JIeHAJIOy H UeHKMHa (1931),
Fop3 n ApyrHx (1936), Llepxaccxoro (1949, 1950, 1951), Ka6acco
II Koxca (1949, 1952), Bexepa FI Apyrnx (1954), MaFITOBaHU (1954)
H aPYFHX aBTOpOB nOKa3aJIH Ba:KHOe 3HageEHe peaKUHH HeHTpaJln3a-
unH AJIH n3y'eHu5i 4yMbI BJIOTOHAHbIX n nOATBepAWJIH, 4TO CMeCb BH-
pyca H rnnepHMMYHHOH CbIBOpOTKH B onpeaeJleHHbIX COOTHOuleHHHX
He BbI3bIBaeT 3apa}KeHF BOCnpHHM4HBbIX }KHBOTHbIX H KypHHbIX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
3M6pHOH0B. PeaKUHH Hei3TpaJIH3auHH MO}KeT nPHMeH5ITbC5I AJI51 BbIHC-
HeHHH THna BbU ejI#HHOrO BHpyCa, AJI5I OnpeAeJIeHHH YPOBH5I allTIfTeJI
B KpOBH C UeJIb1O ,gHaFHOCTHKH H BbIHCHeHH51 COCT051HHH HMMyHHTeTa.
PeaKUHA npeLHnHTauHH
17o ,I(aHHbIM a. KOHeBa (1912), CbIBOPOTKa rHnepHMMyH113Hpo-
BaHHbIX co6aK n;pHMeHHJIaCb AJTH nOCTaHOBKH peaKUHH npeuHnHTa-
IIHH. OaHaKO pe3yJIbTaTbi 6bIJIH HeonpeAe.leHHble. Y (D. OpJIOBa
(1922) ;peaKl-wH npeIHHHTaLHH XOT5I nOJiy4aJI Cb Ha rpaHHue conpH-
KOCHOB#HH1 rHnepHMMyHHOH npOTHBO4yMHOH CbIBOpOTKH C 3KCyjja-
TOM H3 6ploII1HOH HOJiOCTH 4yMHbIX co6aK, HO BcerAa 6bIJIa c.na6o
BblpaiiteHa.
BaIiJIb H Apyrlle (1944) ofHcaJ1H McTOA agcop6LHH BHpyca 4yMb1
nJIOTOHJaHbIX Ha y6HTbIx HarpesaHHeM 6aKTepHSIx Serratia marcesens,
a TaK]Ke Bact. prodigiosus H noc.ne4yloLueH Hx arrJIIOTHHaLHH cneuH-
q)H4eCKOH CbIBOpOTKOi3. Y6HTble 4yaeCHble 6aKTepHH CpaBHHTeJlbHO
.nerKO Harpy}KaJIHCb CneuU(JJH4eCKHMH aHTHreHaMH, COAep)KaIUHMHCSI
B opraHaX, Bbljie.,1eHHHX H KPOBH Co6aK H XOpbKOB, 60JIbHbIX 4yMOH,
ii cneuH(j)H4eCKH arrJlloTHHHpOBaJIHCb CbIBOpOTKOH HMMyHHbIX co6aK
go pa3BejjeHH5i 1:80. 1-IOIIbITKa T. A. KOHAaKOBa (1949) HCHOJlb3O-
BaTb (jJeHOMeH aJiJi06Hoq)apHH, OTKpbITbIH TI. A. 3HJIb6epoM (1933),
H pa3pa6OTaTb M#TOjj Harpy3KH 4y J1 CHbIX 6aKTepHH BHPYCOM 4yMbI
HJIOTOHAHbIX C nOCJIeAyioLueH arrJIIOTHHau Ieii cneLH(1)HTIeCKOH CbIBO-
POTKOFI He 6NJIa aOBegjeHa AO KOHua.
PeaKuHA reMoarralOTHHauHH
B OHbITaX Xaira (1948) XOpbKOBbIH BapHaHT 3M6pHOH-BHpyCa
4\ Mbl HJIOTOHJjI1bIX HC Bb13bIBaJI 4eTKO BblpaMKeHHylO reMOaII'JHOTHHO-
UHK) 3PHTPOUHTOB KyP H MOPCK14X CBHHOK.
Flo B. BJIaAIIMHposy (1949), BHPYC 4yMbI fJIOT05IJ_jHbIX O6JIaJ[aeT
rCMOaFFJIIOTHHHPYIOLuHMH CBOFICTBaMH B OTHOIIeHHH 3PHTPOLHTOB
JInrylueK. BH!pyc 3TOT HaXOjjHTCH B CbIBOPOTKe KPOBH 4yMHbIX co6ak
(Ha 7-10 AeHb 6oJ1e3HH, MaKCIIMaJIbHOe pa3BejjeHHe 1:160) H C06aK-
1)eKOHBaJIeCueHTOB (Ha 40-45 AeHb nocJIe 3a60JIeBaHHn-1 :40, 1:60).
17o era Coo6LueHHK), reMOarFJIlOTIIHHpyIOLUHMH CBOFiCTBaMH He o6JIa-
AaeT BHPYC 4yMbI fJIOTOHJjHbIX, coAep KaluHHcrI B q)HJIbTpaTe B3BeCeI1
Mo3ra, ceJle3eIIKH H KpoBH CO6aK, naBHIHX OT 4VMbi, B XOpHOaJIJIaHTO-
HCHOfI ?KHJJKOCTH KYPHHbIX 3M6pHOHOB, 3apaiKeHHbIX BHpyCOM 4yMbI
HJIOTOHjjHbIX, a TaKx{e B CbIBOPOTKe KpOBH co6aK, B35ITOH B nepxoA
nepBOrO TeMnepaTypHOro B3JieTa. HopMa.IbHwi ace CbIBOPOTKa Co6aK
arrJIIOTHHHPyeT 3p1TPOUHTbI JI51ryLHKH B pa3BeAeHHH 1:10, 1:25.
Hanni xKe Hec.nejjoBauHA (LIepxaccKHFi, 1949, 1950) noxa3aJIH,
4TO BHPYC 4yMbI HJIOTOHAHbIX He o611aaaeT reMOarrJIIOTHHHPYIOHZHMHL
11. E. C. 4epKaccKHA 161
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CBOI3CTBaMII B oTHOHIeHHH 3PHTPOIJHTOB JIHryHIKH, KypHIjbl, MOPCKOH
CBHHKH, 6apaHa, Jioma, u m YejlOBeKa. TorJja y aBTopa B03HHKJIa HJjesl
HOCTaBHTb peaKuHIO reMoarrJIIOTHHau.HH Hao6OpOT- CO CHeIjHO)HJIe-
CKOCI CbIBOpOTKO13.
flepBble }Ke OHbITbI HOKa3aJIH, LITO CHeuH()HqeCKHe CbIBOpOTKH
arrJHK)THHHpyIOT 3PHTPOUHTbI JISFrymeK, ToFJTa KaK CbIBOPOTKH OT He
6oJleBiuHX LlyMOl1 co6aK 3TO1I CHOCO6HOCTbIO He o6JlaJjaloT. 3TO SIBJIe-
IiHe MaJIO H3y'IeHO. MO)KHO TOJIbKO npeAHOJIaraTb, '-ITO npH onpeAe-
JIeHHbIX cnoco6ax rHHepHMMyHH3aL1,HH co6aK B HX CbIBOPOTKe o6pa-
3yIOTCH reMOaFIJIIOTHHHHbI. YKa3aHHoe OTKpbITHe HpHBe,,io K JIaJIb-
HdILIHM HCCJIeJjOBaFIHSHM. OHM nOKa3aJIH Bb1COKyIO reMoarrJIIOTHHH
pY1OIIjyIO CHOCO6HOCTb rHnepHMMyHHbIX CbIBOpOTOK, Cb1BOPOTOK peKOH-
Ba.necI eHTOB (Jjo 1 : 1024) AaxKe tlepe3 1,5--2 roAa, a y BaKLjHHH-
POBaI1JI61X )KHBOTHbIX y}Ke Hepe3 10--15 ;jHeil IIOCJ[e HpIlBHBOK;
CbIBOPOTKH }KC 3aBeJjoMO 3AOPOBbIX co6aK a rr.7IOTHHHpoBaJIH BpH-
POIjHTbI TOJIbKO B HepBbIX 3-4 pa3BeJ1,C11HAX I.
Y Hepe60JIeBHIHX co6aK MbI 06HapYXiHBaJHI IICITpaJIH3yJOHjHe
aIITFITeJIa Jja)Ke HOCKOJ1bKO JIeT CIIyCTSI-B THTpe I : 64 (++?+) H
1:128 (+++) ; H03TOMy BHOJIIIC BO3MOHKHb1 CepojIOrHgeCKHe HcCJIe-
JIOBaHHSI KPOBH BOCnpHHM9HBbIX }KHBOTIIbIX Ha HajiHgHe 11 KO-
.IIHVeCTBO npoTH3oTdyMHb1X allTITTeJl, KaK Ho)jco6Hb113 criocA peTpo-
CHeKTHBHOrO JIHarII03a IIyMb1 AJIH 3HFI300TOJI0IIILIeCKOrO HporHO3a, a
TaK}Ke HpH J(0H CKe co6aK Ha BbIBOJjKH, BbICTaBKH, COCTH3aHHA H T. H.
It JjJISI Bb1ACIIeHHSI, HMMyHHbI JIH K IIyMe HJIOTOSIJjHbIX HpHo6peTaeMble
co6aKH. OAHaKO O)eHOMeH peaKiHH reMoarc.IK)THHaLIHH HecneuII( n-
4eH: arlJIIOTHHHHbI, CKJIeHBa10HjHe 3pHTpOIjHTbI .:IArynleK, co ep)KaTCT
It CbIBOpOTKaX 3JjOPOBbIX co6aK B pa3BeAeHHHX Jjo 1 : 8, 1 : 16, a
uHor ja H BbIHIe; OHH MOryT TaK}Ke COJjep)KaThCSI B CbIBOPOTKaX co6ai,
6oJIbHbIX (HJIH nepe6ojieBHIHX) ApyrHM.H BHpyCHbIMH HHO)eKUHRMH.
1iJKe
I : 128 (++++ HJIH +++);
I rlpiiBeaeHHbie XaHHbie TaKN(e HOKa3bIBaIOT, TO COO6HieHHble BJIaJ IMHpOBbIM
reMoarrJIIOTHHHpyioIH,He THTpbI CbIBOpOTOK HeCKOJIbKHX co6aK HenpaBHJlbHbi H
C03aatOT H3BpaIIIeHHOe HpelLcTaBJIeHHe 0 McXaHH3Me, XapaKTepe II BpeMeHH:
HaKOnJIeHH I reMOarrJIIOTHHHHOB B KpOBH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
6) 1 % B3Becb Ha 0,7% pacTBope XiOpHCTOro HaTpnx ABa>KAbi
OTMbITbIX BPHTPOIIHTOB o6bIKHOBeHHOIi JI5IryLHKH;
B) MaTepHaji, HCCJIeAyeMbII3 Ha co ep>KaHHe BHpyca 4yMbI wio-
T05IAHbIX.
HpueOT08J7eHue 838eCU 3puTpotfuTO8. a5IFY HKy nepeA B35ITHeM
KpOBH noMemarOT Ha 5-10 MHHyT B TeIpMOCTaT, noejie 4ero y Hee
HO>KHHgaMH OTpe3aK)T OAHy H3 KOHe4HOCTeii HeCKOJIbKO BbILHe CK IKa-
TeJIbHOro CyCTaBa H CO6HpaIOT 20 KaneiIb KPOBH B COCyA C 100 MJI
1 % paCTBopa JIHMOHHO-KHCJIOrO HaTpHH. B3Becb KpOBH B36aJITbIBaJOT
H (4HJIbTpyI0T 4epe3 2 c io MapJIH c He60JIbWHM KOJIH4eCTBOM BaTbI.
flpO(kHJIbTpoBaHHyIO KPOBb aeHTpHq)yrxpyloT 20-30 MHHyT. 3aTer
HaAocaAo4Hyio )KHAKOCTb OTcaCbIBaK)T, a B npo6HpxH HajiuBaloT AO
nepBoIiagaJlbHOro o6'beMa 1 % paCTBOp JIHMOHHO-KHCJIorO HaTpHSI,
TIuaTe.nbHO nepeMelnHBaloT COAep}KHMoe npH nOMOHjH fHneTKH H
I&eHTpn(j)yrHpyIOT 20-30 MHHyT. flocjie 3TOrO Ha, ocaAo4HyK) >KHA-
KOCTb OTCaCbIBaK)T, a B npo6HpxH c OTMbITbIMH 3PHTPOUHTaMIi HaJIH-
BaiOT AO nepBOHagaJIbHOrO o6'beMa 1 % paCTBOp JIHMOHHO-KHCJIOrO
HaTpHH. flpHrOTOBJIeHHaH TaKHM o6pa3oM ABa>KAbI OTMbITa5i 10%
B3Becb 3pHTpORHTOB MO)KeT 6bITb HCnOJIb3OBaHa B Tegeilne 3-4
AHeli npH YCJIOBHH xpaneHHSi ee npH TeMngpaType 4-5?.
IlocTanoGKa peaKquu 3adepalcKu aeMoaeeAIoTUHa4uu. PeaKUHIG
3aAep>KKH reMoarrJIIOTHHaIZHH CTaBHT B 06'beMe 1 MJI npH KOMIIaT-
HOIi TeMnepaType B a!rrJIK)THHauHOHHbIX HJIH 06bIgHbJX 6aKTepHOJIo-
rH4eCKHX npo6HpKax. I4ccJIeAyeMbIli MaTepHaJi npHI'OTBBJIHBaIOT TaK
>Ke, KaK H AJIH HHOKYJI514HH B KypHHble 3M6pHOHbI, H pa3BOA5IT B reo-
AIeTpHJecKol3 nporpecCHH OT 1 : 2 AO 1 : 512-1024. jjJix 3TOrO B Ka>r_-
Ayio H3 10 npo6HpoK Ha.nHBaIOT no 0,25 MJI 0,7% pacTBopa xJlopH-
CIOrO HaTpHH. 3aTeM B nepByIO npo6HpKy (pa3BeAeHIIe 1 : 2) Ao6aL-
JIHIOT 0;25 MA HCCJIeAyeMoro MaTepHaJla, TIILaTeJIbHO nepeMeilHBaioT
H OT4eJIbH011 nHneTKOf! nepeHOCHT 0,25 MJI CMeCH BO BTOpylo npo611p-
Ky. Bee nocJIeJylomHe pa3BeAeHH51 rOTOBHT OTAeJIbHbIMH nHneTKaMH,
T. e. nepeHOCHT no 0,25 MJI CMeCH H3 BTOPOI3 npo6HpxH B TpeTblo
(pa3BeAeHHe 1 : 8), H3 T'peTbeii-B 4eTBepTy10 (pa3BeAeHHe 1 : 16) H
T. A. 1'13 nOCJIeAHeii npo6HpKH (pa3BeAeHHe 1 : 1024) 0,25 MJI CMeCH
BbIJIHBaioT, 11ocae BTOrO B Ka>KAylo npo6Hpxy HaJIHBaIOT no 0,25 MJI
arrJIIOTHHHpylouAeii CbIBOPOTKH B pa3BeAeHHH, COOTBeTCTByIOJ4eM
LieTbIpeXKpaTHo arrJIIOTHHHpyJOLLjeH A03e. OAHoi arrJIIOTHHHpyK)LUe1i
A030ii CbIBOpOTKH HBJISIeTCH ee THTp, yKa3aHHbIci Ha 3THKeTKe, T. e.
TaKoe ee MaKCHMaJIbHoe pa3BeAeH4e, KOTgpoe CHOCO6HO BbI3BaTb.
arrJHK)THHauHIO 9PHTPOIkHTOB JIHryUlKH (++? HJIH ++). ECJIH, Ha-
npHMep, THTp CbIBOpOTKH, yKa3aHHbIIi Ha 9THKeTKe, paBeH 1 : 256, I-o
4eTbipe arrJIIOTHHHpyJoigHe A03bi B o6'beMe 0,25 MJI 6yAyT coAep>KaTb-
CII B pa3BeAeHHH 3TOIi CbIBOpOTKH 1 : 64. AI'rJIIOTHHHPYIOLUYIO Cbli30-
pOTKy pa3BOA5IT 0,7% paCTBOpOM XJIOjpHCTOrO HaTpHr. r10CJIe nepe-
McIIIHBaHH51 B Ka>KAylo npo6Hpxy A06aBJ13IIOT no 0,5 MJA 1 % B3BeCH
OTMbITbIX 3PHTPOIUHTOB JlIryii[IfH H CHOBa TLL(aTeJIbHO nepeMeIIIH-
BaIOT (Ta6Ji. 12).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ta6auLk a 12
Cxema nOCTaHGBKH peaxglln 3aaep7KI11 reMOarrJIIOTHIIaILHH
npn vyre naOTOSAHIIx
0,7 % paCTBOp xaO-
pnCToro naTpiiA (B MJI) 0,25
i1cc3eAyeMbiil Ha
iiaia"Tme BHpyca Ma-
TepHaa B pa3BejeI1H if
1 : 10 (B Ma) . . . . 0,25
1 o paCTBOp apH-
TpO1UHTOB 13F' TIT I HJIH > (IIaI))(, 1936, 1937,
1949, Fpini H apyme, 1939); deAiueAuuu3upytou4uu 3Krgeg55aAUT (Bep-
JIHHJi,e, 1939 H . p.) HJIH euneplKepaT03 JIaIi, TaK Ha3bIBaeMaH HJiH (MaprapHTa LIIaTium, 1944, 1951, H
np.) ; paccestntlblu aut4e4MAUr UHHeca (1947) HJIH OCTpbtu AiHO-
JICCCTaeHHbtu cmmAepo3 co6aic LlIepepa (1944) H ap. Ha caMoM jjeate
BCC 3T0 JIHIHb 6oJIee HJIH Meuee pacnpoCTpaueuHbie 3a py6e)K0M
(LLIBeuFx, CLLIA, AHFJIHH H np.) H cpaBHHTeJIbHo pejjxo BCTpeualo-
UWCCSI B CCCP oC06ble KJIHHH~IeCKHe (j)OpMbI LIyMbI y co6aK (KOp-
H0BCKH{I, 1950, Fops, 1950, iI np.), O6yc.noBJIeHHbie rIJI1OpaJ1HTeTOM
Blipyca '-lyMbI HJIOTOAjjHbIX (YJIbpHX, 1949, 1950, H jjp.).
IIOJj Ha3BaHH51MH-3Clt4ecfbaAUT, AUcuu 31-t(ec/'aAt1T tj co6alc, Utl-
(I)etc14uotltlbl6 eenaTUT co6alc, co6aKUU 31-ldoTeAuUT H jjp. oHHCbIBaeTCH
HH(JJeKIjHH, HMeIOHjal euuriyio 3THOJIOFHIO H 5IBJIHIOIIjaHicH HO COBCTCKOA
H030JIOFHH O)LHOFl H TOI3 }KC 6oJIe3HbI0-UHCPelct4uonnbtAi 3tlt4e(fJaAO-
AtUeAuTom nAOTOJldnblx. KaK caMOCTOSITeJIbHbie H030JIOrp1eCKHe eJjri--
HHIjbI, B JIHTepaType f)HrypHpyIOT ulryreapdcicaq 6oAe3Hb, HJIH TUq'
co6aic, H AefTOCnUpo3, XOTIT 3T0 3a6oJIeBaIIHe 0J[HOI-I H TOFI >KC99THOJIOruH (B. 3. LIepHsK, 1948).
B JIHTepaType yHOMHHaJOTCH TaKHe BHpyCHbie 6OJIC3HH C06aK, KaK
unq5etct4uoIhast aneMu;l n eIH.
B pe3yJlbTaTe pa6oT MHOFHX BBTOpOB yCTaiO1-,3e:'I0, 'ITO KCyXal
4yMa> He HMCCT CaMOCTOnTeJIbHyio 3THOJIOFHH), a BbI3blBaeTC9 OCO-
6oII HMMyHOJIOFH'IeCKOI1 pa3HOBHLUIOCTbIO Bllpyca TiyMbl IIJIOTOTIJ1,HbIX
(JjajurHHr, 1949, I'op3 H up.).
,ILEMHEJIHHH3MPYIOI 3fltjE4)ARMT 1HT HJIH rMIIEPKEPATO3
HOA HH3BaHHeM HBJI IeTCH JIHI-Ub-KMOAH(pHuH-
pOBaHHbIM BHPYCOM TIyMbI co6aK, y KOTOpOI'O B 60JlbuleH Mepe, TIeM
y ApyrHX UITaMMOB, BblpaB{eHa He1pOTpOUHOCTb> (FOp3).
B OnbITBX nepeKpecTHOro HMMYHHTeTa Ha P1(S) H B OnbITaX HeH-
TpaJIH3aUHH H nepeKpeCTHOrO HMMYHHTeTa Ha XopbKaX Ka6acco
(1952) LIOKa3aJT HMMyHOJIOrHTIeCKOe To}KAeCTBO co6aTIberO BapiaHTa
BHpyca TIyMbI nJIOTOHAHbIX H BHpyCa jeMHe.nHHH3HpYIOIHero 3Hue4Ja-
JIHTa co6aK. XOpbKH, HMMYHHble K TIyMe, 6bIJIH HeBocnpHHMTIIIBbI,H K
3apa)KeHHIO BHPYCOM AeMHeJIHHH3Hpyiou[ero BHued)aJIHTa.
BEWEHCTBO
KJIHHHTIeCKHe nPH3HaKH H nOBeaeHHe 60JIbHOH co6aKH npH 6e-
IIIeHCTBe OTIeHb pa3Hoo6pa3IibI, 0006eHHO B nepBble AHH 3a6OJICBaHHH,
H HepeAKO nOXO)KH Ha TIYMY HJIOTOSIAHbIX.
CHJIbHOe B036y)KAeHHe Co6aK, 6o.IbI-IbIX TIyMOH, HanoMHHalow.ee
KJIIIHHKy 6eluexcTBa, Ha6JIloaaJIH C. KypHH (1913), C. A. Fpioliep
(1915), B. B. KOLIeBOH (1928) H ap. OAI-IaKO nepnoA B036yBKaeHHSI
npH TiyMe, B OTJIHTIHe OT 6eLHeHCTBa, KpaTKoBpeMeneH. Oco6exno Ha-
LIOMHHafOT HePBHYIO KJIHHHKy TIyMbI THXHe (JOpMbl 6eIIIeHCTBa. BbIJIO
Aaxce MHeHHe (J. i-1epHOXBOCTOB, 1863), TITO TIyma y co6aK Ha BbICO-
Te CBoero npOHBJIeHHSI .
Ilpi-I 6euieHCTBe OTCYTCTBYIOT XapaKTepHble )IJISI TIyMbI y c06aK
KaTapaJlbHble HBJIeHHx. 4yMa OTJIHTIaeTC5I OT 6euleHCTBa OTCYTCTBHeM
ai'peCCHBHOCTH y 60JIbHbIX. IIpaBAa, A. A. KpaeBcKHH (1887) Ha6Jito-
7 ,aJI CJiyTIaH 3a6OJIeBaHHA TIyMOH C np05IBJIeHHCM arpCCCHBHOCTH HO
OTHOLUeHHIO K J11OA5IM H K )KHBOTHbIM. Y 6eLueHbIX co6aK napaJlH-
3YIOTCH rJIOTaTeJlbHble MbJIIIubI, TIero HHKOUAa He 6bIBaeT y TIYMHbIX
co6aK.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B 65 - 95% cJlyyaeB Ha CeKuHH co6aK, norll6IHNx oT 6elucHCTBa,
B -KC.1IYJl,Ke o6Hapy}KHBalOT Dec-beJj06Hble npejMCTbI HAD, oTO, 110
B. K. Bo.nfo, TaK}Ke XapaKTepHO gJIH 6eHIeHCTBa,-IIyCT01'I }KeJlyjjoK.
,UJIn jjHarH03a, nOMNMO allaNIHOCTHHeeKHX (yKyC, OCJIioHeHHe)
K.IIIIHHKO-3HH300TOJIOrHgeCKHX H naTOJIOroaualoMll9CCKHx JjaIllibIX,
Ba}KHOC 3HaLIeune HMeeT INCTOJToI'HLICCKoe HccJIeJj0Balllle M03ra IIa
TeJlbua Herpes (oxpacxa no C. H. MypoMueBy, E. H. TypeBHLIy),
ripri crieiine McTOJja (Ja30KOHTpaCTII0FI MHKPOCKOIINH (A. A. ABOKBH,
1953), a TOK}KC 6HojiorH1IeCKann npo6a Ha KpOJIHKaX.
BOJ1E3Hb AYECKH (HCEBAOBEWEHCTBO)
BOJle3Hb AyecKH y co6aK H riYLUHbIX 3BepeH pcFHC1-papyeTCSr
CpaBHHTeJIbHO peAKO. OjijaKO 3Ta 60JIe3Hb, HO-B11jjHMOMY, paCnpO-
CTpaHeHa cpejuH HHX 3HaLIHTeJIbHo 6oJIbHIe, LIeM JTO npHHSITO C'IHTaTh.
K. H. ByziHeB (1949) riOKa3aJI, LITO'laCTb OCTpbIX 3nH300TH'-leCKHx
3a6OJIeBaHHH e3,JOBbIX co6aK IIa KpakllieM CeBepe B 1933, 1935,
1937, 1939 H 1941 rr., Hb13bIBaBWHX 60Jlbnly[O cMepTHOCTh H JjNaru'O-
CTH OBaHHbIX KaK KHepBHaSI (lOpMa> LiyMbi co6aK, Ha CaMOM ge.,ic
6bIJln 6oJIe3Hblo AyecKH Co CJIej[yioIIjel1 KJIHHH'IeCKOI1 KapTHH013: Co-
6aKa OTKa3b1BaeTCSI OT KOpMa, CHaLIaJia yrHeTeiia, 3aTeM B036y3K;-w-
Ila; piHHT, KOH'bIOHKTHBHT, CJIIOHOTegeHHe. C nO5BJICIIICM CLIJIbH01-0
3y,ra Co6aKa BOOT H HeHCTOBCTByeT. 3aTeM OHa j[eJIaeTCSI yrHeTea-
IIOFI. B0311HKaIOT rlBJleIlH51 napanape3a H nprna,jKH C KOHByJIbcH IMH.
TeMnepaTypa 41-41,5?, 3aTeM cuIDKaeTCn. 3a6o.neBaloT Ao 90% KolI-
TaiTNpyjOHjIIx co6a1K. CMepTHOCTb n01IT1I CTOnpOTjel-ITHa51, CMepTh.
IIacTYHaCT B 1-2 JJHB.
Ha ceKluH xapTHHa ocrporo cencHCa, xpOBOH3JI14HHH5], pacgechl,
OTe9HOCTb, NH(IHJlbTpaTbl, PHHNT, KOH'bIOHKTHBNT, LIaCTh TyJIOBHIL I
o6H.uIbH0 CMOileHa CJIIOHOH, BO pTy, }KeJIyjjKe HeC'bejo6Hble npeAMeTbI.
4yMa y co6aK OTJIHLIaeTCI OT 6oJIe3HH AyeCKH 6o iee npOAoJI}KII-
TeJIbIIbIM TegeHHeM, McHee pe3KHMH HepBHbIMIf HBJIe[INHMH it a6co-
JIIOTIIbIM OTCYTCTBHCM 3yJ1a. HeBOCHpnHMLIHBOCTb K LIyMe HJIOT051, HbIX
11 BOCTIpHHMLIHBOCTb K 6oJIe3HH AyeCKH MCJIKHX Jla6opaTOpHbIX ih);-
BOTHbIX-6eJIbIX MbnIIe13, KpOJIHKOB, MOPCKHX CBHHOK (HHKy6aulloll-
1lb113 nepnojj 1-3 JjHSI)--NO3BOJInCT HCnOJIb3OBaTb HX RJift uj-i x"IC-
peHuHaJIbHOII JjHarHOCTITKH.
KAMMATCKAR AHKOCTb COBAK H (3JIbTOH), He-
OAHOpOAHa. 14auje BcerO Ha6JlloaaeTCH cJIa6oCTb, HapaJIHTIH, arpec-
CHBHOCTb; 60JIbHb1e CO6aKH CTaHOBSiTCH >, KyCaIOT }KH-
BOTHbIX H JI109eH, Y HHX TegeT CJIK)Ha.
E. M. TypeBHq H A. E. Te651KHHa (1947), B. H. IlepcTo6oeB.
(1949), P. A. KaHTapOBHTI (1956) BbIAeJISIJIH H3 M0317a >KHBOTHbIX,
H0rH6mix OT CAHKOBaHHSI>>, BHpyc, CXOAHbII3 B aHTHreHHOM H HMMy-
HOJIOrHYeCKOM OTHOIIIeHHH C BHPYCOM-(IF)HKC 6el1IeHCTBa, HO OTJIHTIaio-
II.I,HMCSI OTCyTCTBHeM Te.neu Herpes, (p HJIb'11pyeMOCTbIO Tlepe3 CBe'jII
13epKe(JeJIb4a, KOTOpble 3a4ep>KHBaIOT BHpyc 6eIHeHcTBa, n )1p.
3apa>KeHHe KAHKOCTbK)> HPOHCXOAHT HCKJIK)4HTeJIbHO Tlepe3 YKYC bI
60JIbHbIX >KHBOTHbIX (L11epCTo6oeB). HHKy6aUHOHHbIFI HepFO4 OT 21
Ao 120 AHeii; CMePTHOCTb-OT 8,5% go 62%.
BOJIbHble }KHBOTHble OTKa3bIBaIOTC5I OT KOpMa, BHaTIajte HyrJIHBbI,
Ile BbIHOCHT OKpHKOB, IHyMa; TIepe3 12-48 TIacOB HO5BJI55HOTCH arpec-
CHBHOCTb, HoeAaHHe KaJIa, TpaBbl, Hecbe406HbIX HpeAMeTOB, HapaJIHT1
HII}KHe13 gCJII )CTH, H3bIKa, rJIOTKH H rOJIOCOBbIX CBH30K, MbIWI; KO-
HeLIHOCTeI3 H 3aTeM MbIIHI[ TyJIOBHiua. Pe3KO HaaaeT TeMHepaTypa.
Co6aKH HOrH6a)[oT HpH HBJIeHHHX aC4)HKCHH. HaTOJIOI'oaHaTOMH-
TIecKHe H3Me11eHH5I He XapaKTepHbl HJIH BOBCC OTCYTCTByIOT. TeJlbUa
Herpes He o6HapyxcllBa!OTCSI.
BcHbIIUKH KJ[HKOBaHHH>>, Ha6JIIoAaBIHHecx B 1947-1948 rr. Ha
KaMgaTKe, TaFIMbIpCKOM HOJIyOCTpOBe H Ha KOJIbIMe, B 1953-
1954 IT. B HH30BbgX O6H H H.-KOJIbIMCKOI3 TyHApe, HPOTeKa.I1i tipe3
BbITIa13HO OCTpO, OXBaTbIBaJIH, KpoMe CO6aK H HecUOB, TaK}Ke BOJIKOB,
K01IOTOB H 6bIJIH TeCHO CBH3aHb1 C 3a60JIeBaHHHMH JIeMMHHrOB.
(A. JIaHHKHH, B. M. CAo6HHKOB, B. A. TaBpoBcKH13, LIa, E. cIep
KaCCKHI3, KOHApaTOB).
OAHaKO BOHPOC 0 Ae1CTBHTeJIbHOIi npHpoAe > HeJIb
351 CqHTaTb peuleHHbIM. IIO-BHAHMOMy, HOA 3THM c60PHbIM Ha3B3HH-
eM CKpbIBaIOTCSI 3a60JIeBaHH5I caMOii pa3JIHT-IHOI-i 3THOJIOrHH: TiyMa
HJIOTOHAHbix, 6oJIe3Hb AyecKH, HH()eKLHOHHbI1 3Hue(jaJioMHeJIHT,
6euIeHCTBO HAP. (E. LiepKacCKH13). HaMH B HacTornee BpeM51 143y-
T1aeTC5I 3TOT Ba}KHbIA BOHpOC.
NHOEKRHOHHASI BPOHXOIIHEBMOHH51
HH(~eKUHOHHaH 6pOHXOHHeBMOHHSI KaK 3THOJIOrHTIeCKH CaMOCTOH-
Te.AbHOe 3a60JIeBaHHe co6aK Hesse H HHKeM C HeO6XOAHMOI3 AOCTO-
EepHOCTbIO He OHHCaHO.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I-IeKOTOpble aBTOpbi (S1Ko6, 1928, A. H. MaxapCBCKH I, 1928,
KajjMo n bpeToFi, 1935, 1937 H ap.) BbIjjeJliIOT 6poHXonHeBMOHHIO
CO6aK B CaMOCTOHTeJIbIIy10 3THOJIOFH'IeCK'lO II H030JIOI'H'1eCKYio ejjH-
HHuY, XOT51 B036Y jHTe.Ib ee HC113BeCTCH. I3OJle3Hb 110 KJIHHHKe OHH-
CbIBaeTC51, KBK T2K Ha3b!BaeMaH JICFO'IHa5I 4JcpMa IIYMbI nJI0TO51THbIX
H OTJIH1I3CTC I OT tIYMbI TCM, iITO npH IIeH HHKOr)ja He 6bIBaeT OCJIO}K-
He1IHiI co CTOp0IIbi jjpyrHx opraHOB.
HH(bEKUHOHHbIH 3HLtE4)AJIOMHEJIHT HJIOTOSI)LHbIX
(HH EKUHOHHbIH rEHATHT COBAK)
BHaiiaJle HH4)eKl HOHHblil 3HueO)a.noMHeJInIT JIHCHu cMeWIIBaJIH C
4yMO1-1 H TOJIbKO noc ie j1,OJIrOJIeTHCFO H3ytiel1H51 co6pannoro MaTe-
pHa.na oTJjH(jJ(pepexunpoBaJIH jwlIHbie 3a6oJ1eBa11na (I'puH, 1928).
HH(~eKLUiOll1ibII1 renaTHT C06aK (HH(~cKuH0HHbII1 3Hue(laJIOMHeJIHT
rIJIOTO5Ip,HbIX) OTJIHqaeTC5I OT tIyMbI TeNI, 1-ITO KHBOTHble OCTaIOTCH
K-
110 TOJIKOBaTb KaK npO5IBJ1eHHe HHO)eKu IoHIIOI'O renaTHTa, a He TIyMbl.
HH(I)eKuHOHHbIii 9HIle()aJI0MHCJI11T B Ji3COB0jj'IeCK11X X0351HCTBaX HpO-
TCKaeT K2K CTaIJIIOIlapHOe 3a6OJI0,BaHHc. OH HepeJ,KO TSIHeTcFI rOJja-
Mu, npOSIBJ 5ICTCSI CnopaAH'IecKH, 6o.imiuei5 u0CTbIO B OCTpOII 4)opMe,
c npeO6J1aLjauneM HBJICHHII CO CTOpOHbI uenTpaJIbHOi! HCPBHOK CH-
CTCMbI. Ilepe6o.leBLnlle Ha j(JIHTCJII-HIbIfI CpOK 5IBJ15IIOTC51 BHpyCOIIOC14-
TCJI5IMH. HanpOTHB, 'IyMa O6blelio 3alIOCHTC51 B X035IIC.TI3O 113BHe,
npOTeKaCT McHee OCTpO, c npeo6JiajaHHeM HBJICIII1il CO CTOPOHbI Jjbl-
XaTeJIbnOrO H >Kejlyjj04HO-KHHIe4iIOr0 anrlapaT0B. B 3BepoX035IIICTBax
'IVMa He CTauHOHapIIa IT, KOK npaBHJIO, 11a CJlejjy1onLIll1 rojj nOCJ1e
Bn11300TIIH lIe HOBTOP5IeTC51. B OTJIHOIIC OT Ilepe60JI0B111HX BHIjcO)aJIO-
M[1eJIHTOM COMKI1, ncpC60JICBLlHe tlyMlOil, npHHOCSIT 3;IOpOBbilI npH-
HjIOJJ. HO AIIIIHbIM naTOJloro-aHa'I'oPiti'IecIcIlx HcCJIeJ oBa1IHu, 3a6oJie-
Banne 3aperHCTpnpoBaHO B A11r3IHH 8,5%, ~BCUHH-3,4%, I'epria-
HHIi-2?/o BCKpbITbIX co6OK. B CCCP (B. 3. LlepHgK H upYrne,
1955) OTMCIICIIO BCeI'O HCCKOJIbKO CJIy'-IaeB 3TOr0 3a6o.neBaxnn CpejjH
CO6OK.
Ho Lla,i oKy II KapJlcolly (1950), 113 96 co6aic, y KOTOpbIX 6bIJ1
JjHOFHOCWII)OB3II IIH(,IeK1HJOHIIbIfi FCIIaTHT fOH J~eT LgnilOM o6CJiejl,o-
Balialt JjfaFH03 6LIJI H0JjTBep>Kjje1I TOJIbKO y 11; y 22 yCTaHOBJIena
tlyMa. Ha BCKpbITlilI B 90% C.nVHacn OTMe'Ia1OT cBoeo6pa3I1bIH OTCK
CTCIH{H >KeJIgnoro ny3bIp5I 11 CFO JIO>Ka, KOTOpb111 MHOCHB cilHTaIOT
HaTOFIIOMOHH'IHbINI JjJISI BTOTI 6031(331111. XapalTepc?{ npo3pa'11IhIIi 11J11!
KpOBeHOC11bIIl BKCYJ[aT B 61)Ioiui[oII HOJIOCTH, yBeJIHecIln35l, HCCKOJIbKO
>KCJITyLHH05I IIJIH nOJIHOKpOBH251 ne'-leHb, HOI:pbIT3H O)116pIHI03HbIMH
nJIC1[KaMH, CeJIe3CHKa B 5% CJIyII2eB yBCJI1IzIl'.Ha. O'lcy'rCTByIOT SIBJIC-
Ifi151 rcMopparu9CCKOro 3H'repHTa. THCTOJIOFHgIeCKH Hai6o,nee xapaK-
TepHbI 113"Mlei1lin B netl(HU - J(IICTpO 1HSi H Hexpo6H03.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
C ueJlbio AHcx epeHuuaJIbHOrO AHarH03a MOryT 6bITb HCHOJIb3O-
BaHbI MOPCKHe CBHHKH H 6eJlble KpblCbl, KOTOpble, corjiaCHO AaHHbIM
JIeBeH6epra, By3HHOBa, BaHHOBCKOrO H ApyrHX, BOCHPHHM-
tIHBbI K HH(peKHHOHHOMy 3Hueq)aJIOMHeJIHTy npf HHTPauepe6paJIbHOM
3apa}KeHHM H HeBOCnpnHMTIHBbI K TIyMe, a TaKxte FIOpKM, KOTOpble, no
F'pBHy (1940), HeBOCnPHHMtIHBbI K HH(1JeKUHOHHOMY 3Hue(paJIoMHeJIH-
Ty. MO}KHO HCHOJIb3OBaTb H nOBbIHIeHHYIO yCTORT)HBOCTb co6aIJbnX
LueHKOB K BHyTpHMbIHIeTIHOMy 3apa}KeHHIO BHPYCOM 3Hue(JaJIOMHe-'
JIHTa. 3apwKeHHe, corJiacHO AaHHbIM By3HHOBa H BaHHOBCKOro,
HaCTynaeT npH OrPOMHOI3 A03e BHpyca (1 MJI B pa3BeAeHnH 1 : 10),
B TO BPeMSI KaK 3apaK{eHHe TIyMOi--IIpH Ao3e 0,2 MJI B pa3BeaeHHH
10-3 H AaxKe 10--5. Bypble AHKHe XopbKH, a TaK>Ke 6eJlble a()pHKaH-
CKHe XOpbKH, KOTOPble paHee CTIIITaJIHCb BOCnpHMMTIMBbIMH TOJIbKO
K tlyMe (rpHH), He npHrOJHbI AJISI jH( CpepeHUMaJIbHOA AHarHOCTHKn,
TBK KaK OHM 3a6oJIeBaIOT H 3Hue(paJIOMMeJIHTOM (Fop3 H Ap., 1950,
1951).
AJISI Am(q)epeHuHaJIbnoH AMarHOCTHKH MO)KHO BBecTH B nepeJz-
HIOIO KaMepy rJta3a JIHCHubI nJIH co6aKn MaTepnaJI OT 6oJIbHbIX }KH-
BOTHbIX. Bupyc 3HL e(JaJIOMHeJIIITa 6bICTpO pa3MHO}KaeTC51 B pOrO-
BMue, BbI3bIBaH Tlepe3 3 iI,1IH ee HOMYTHeHHe (4aAAoK H Apyrue,
1950). BHpyc }Ke tIyMbl He BbI3bIBaeT HHKaKHX H3MeHeHHII B
porosllue.
BbICTpoe TetleHHe H OTCYTCTBHe 6oJIe3HeHHbIX CHMHTOMOB CO CTO-
pOHbI AbIXaTeJIbHbIX nyTeli gBJIHIOTC51 HaJeNKHbIM OCIIOBaFIHeM AJI51
).U144epeHUHPOBaHHH y co6aK HH(f eKuHOHHOFO 3Hue(lJaJIOMHeJIIITa
OT tIyMbI fJIOTOHAHbIX.
FHCTOJIOrMtIeCKHI%I cnoco6 AH0epexunpOBaHHH tlyMbl H 3Hue(pa-
JIOMHeJIHTa, HpeAJIO)KeHHbII3 FpIIHOM H 3BaHCOM (1939), OCHOBaH Ha
pa3JIH14HOl3 JIOKaJIH3aUHH B TKaHSIX 60JIblIbIX }KHBOTHbIX mop(oJIOrH-
tleCKH CXOAHbIX TejIeu BKJIIogeHHI I. IIpH TIyMe TeJlbua BKJIIOtIeHHSI Ha-
XOAATCH rJIaBHbIM 06pa30M BHyTpH fPOTOHJIa3MLI H peace BHYTPH
xAep KJIeTOK 3nHTeJIHaTibHoII TKaHH )KeJItIIIbIX npOTOKOB, MOTIeBOro
ny3blpB, 6poHX0B, }KeJIyJOTIIIO-KnHIeT-IHOFO TpaKTa; npH 3HuecaJio-
MHeJIHTe }Ke OHM coAepx{aTCH HCKJIIOTIHTeJIbHO BHYTPH su ep, I'JiaB-
HbIM o6pa3oM neueHli (B. LIePHHK H AP.), COCYAHCTOrO 3HA0Te,IHH, B
JIHM(paTHTIeCKnX y3JIaX H OTCYTCTBYIOT B )KeJITIHbIX I OTOKaX H KJIeT-
KaX rIOBepXHOCTIIOI'O CJIOSI 3nnTeJInI.
Flo UeAbe (1951), MaHcn (1952, 1955) H upyrluM, c noMoLtblo
peaKuFIH CB5I3bIBaHIIR KvMnJIeMeIITa MO?KHO JIerKO OTAH(I3(JJepeHuH-
POBaTb BHPYC 'IyMbI HJIOTOHAHbIX OT BHpyca HH(pCKLHOHHOFO rena-
THTa co6aK.
rHHEPKHHE3H5I
F'HnepKnHe3HSl-3a6oJleBanne co6aK, onIlcaHHOe JIFIHueM H Ap.
(1929). Bo36yAHTeJIeM SIBJIHeTCSI rpaMOTpHuaTeJlbnaSI noJIOTIKa Bact.
hydrophilus (Batt. proteus hydrophilus), BblAeneHHaM H3 KpOBH,
Moira, cnHHHO-M03roB0II )KAAKOCTH H cepAua (Bee 3TO Tpe6yeT HCA-
TBep}KAeHHn).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
XapaKTepHbI: pBOTa, oTKa3 OT KopMa, CTy.TI A-,HJKHFI, C HpHMecbK)
KpOBH H neHbI, TH KeJIbIC Cna3MbI MyCKyJlaTypbI, BO BPCM5 KOTOpbIX
co6aKa HOFH6aCT OT IC(I)IKCnn.
OT gyMbl 6oJTe3Hb OTJIHgaeTCSB OTCYTCTBHCM KBTapaJIhIIbIX HBJne-
HHH CO CTOpOHbI Boca it rJIa3.
NH4)EKRNOHHbII,'I KEPATHT
HH(jJeKUHOHHbIH KCpaTHT-Maio '13y'?Cr[HOe 3a60JTCBa[Ine. HO
AaHHbIM Ma3aHOBa (1932), 3a60JieBa!OT HpeHMyruCCTBeH110 OXOT-
HHUIbH C06aKH B I[113KHX, 6OJIOTHCTbIX McCTaX.
KepaTnT nonBJlHeTcn Cpa3y Ha o6oHx rJ1a3ax II npnBOJjHT K CJIC-
noTe. EMy npeJr1HecTByeT pBOTa, HOHOC, CaMOnpon3BOJIhHoe Bbrr eJie-
Hne- MO9T4, FnnepeMHn CKJlepbl, BbIHOT B HepeJjliloro KaMepy FJIa33,
rHOYIHHK, npeBparuaIOIuHHCSI B 5`I3By.
OT '-l\MbI HJIO'r05TAI1bIX 60JIe3Hb oTJingae'rCq OTCyTCTBHeM pHHHTa.
HKTEPO-rEMOPPAFN9ECKNII JIENTOCNNP03
Y co6aK JICHTOCHnp03 npoTCKaeT OCTpO npH SIBJIeHHRX He3Hagn-
TeJTbIIOH rnnepTepMHn (nrlorAa rnnoTepMHn), nopa}KeHHH KeJnyuou-
HO-KnuIe'IHOrO Tp3KTa (pBOTa, KpaTKOBpcMeHIIhru 3aHOp, CMCHIIIOIIjHH-
CH KpOBaBbIM HOIIOCOM), }KeJITyXe n napaJingaX If gfCT'O 3aKaHgHBaeT-
CSI rn6eJIbIO 6OJIbHbIX.
Y JIHCHij, neCH,0B It ApYFHX HJ1OTOITJWHhrX OCI-IOBHbIC CHMHTOMbI HH-
(i)eKuHOHHOH }Ke.;iTyXH: Kp('ITKOBpeMeHHan( JIHXOpa)jKa, 3aTCM rHHOTep-
MHn, aHeMHA, reMopparHgecKnII JtHaTe3 n raCTpO9HTepHT, HeKp03
CJIn3HCTbIX 06oJTOBCK, Hopa}KeHnfr HegeHH, HOgeK, ueHTpaJibHOTI HepB-
110a CHTCMbI (C. JIIo6aHIeHKO, 1952).
,Jrn Jjn(p(pepeHljnaJIbIIOFO AHaFHO3a 60JIh11I0e 311ageliIle HMeIOT
Jia6opaTOpl-Ibre McTOAbI nccJIeJjoBarIHrT, rJIaBHbIM o6pa3OM 6aKTe-
pHOCKOnn1ICCKHe, CepoJIorHgCCKne u rHCTOJIOrngeCKne. BbIAeJIeHne
JIefTOCfHp M3 OpraHOB yaaeTC9 pe)jKo, FIX Ier'-ie o6Hapy>KFTb B FH-
cToJnorngeCKnx cpe3ax (oKpaCia no JIeBaJHTM-Ho.HKaHOBy). Ham
yeneruHHO yAasaJlocb An(JOepeHHUHpoBaTb gyMY n:IOToIuwbrx OT .nen-
Tocnupo3a B peaKUnH MrrxpoariJllOTnrlarjnn--JIH3TICa.
WTYTFAP.LLCKASI BOJIE3Hb HJIN TWO COBAK
3TnOJIOrnrI IIITyTrap!jcKoH 6oJIe3IIH 'rOgHO He yCTalloB,nena. Ho
K.HapeH6exy H IIIycjT(lHepy (1931), B. 3. ulepl-Inxy (1948), ona lIB-
JIICTCn HOAOCTpOH nJIH XpOHHLIeCKOH (j)opMOH 6e3}KeJITyIUHOF0 Jlen-
TOCHHp03a, no npeACTaBJIneT Ca MOCTORTeJIbHyIO ITO30JIOFH ieCK'JO
eJjFHHuy, B036yjjIITCJIeM KOTOpOH 51BJIHeTCH oco6blH BHA JICHTOCIIHp
Leptospira canicola KIarenbeck, naTOreHHbIH TaK}Ke H AJIH geJlOBe-
Ka H CJIa60 naTOFeIIHbIH AJIH MOPCK14X CBHHOK.
Flo A. KopOTHtIy H ApyrHM (1940), HITyTrapucxar 6oJIe3Hb-BH-
pycnoe 3a6oJleBaune, no B. B. E(ppeMOBy (1948), Fo.nhjjeHT6eprepy
H JjpyrHM-aBFTaMHHO3.
Hp1 IuTyTrapACxoIr 6OJne3HH HaTojlornllecKHH npouece HepeJLKO
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npOTeKaeT 6eccHMrTOMHO HJIH B CTepTOI-I (j)opMe (I-I. H. AMOCeHKOB
H E. M. flonoBa, 1954).
BoJIe3IIb npOTeKaeT OCTpO H OTJIHLIaeTCSI OT LIyMbI fJIOTO5f1 HbIX
OTCyTCTBHeM KaTapa JjblxaTeJIbHbIX nyTe13, rJIy6OKHMH H3-b5I3BJIeHHH-
MH CJIH3HCTOI3 pTa, HenpFIRTHbIM 3anaxoM H3 pOTOBOI3 nOJIOCTH, npe-
HMynjeCTBeHHbIM nopa)KeHHeM }KeJIyJjOLIHO-KHHIetIHOrO TpaKTa.
ITaTOJIOroaHaTOMHtgeCKII B 100% CJIytIaeB OTMetIaeTCH aH~Oy3-
HbI1i 513BeHHbI4 9HJjOKaPAHT JIeBOro npeJlcepAH51, He Ha6JIloJja1OWH13C5I
HH npH KaKHX 1 pyrHX HH(peKuHOHHbIX 3a60JIeBaHH51X (LIepH51K).
)JISI JjH()(pepeHljHaJlbHoro AHarHO3a peKOMeHJjyeTC5I 3apa),KeHHe
MOJIOJjbIX MOPCKHX CBHHOK, HCCJIe) oBaHHSI CepOJIOrmeCKHe H Ha Ha-
JIHLIHe JIenTOCHHp B Mode 6OJIbHoro }KHBOTHoro, a npH BCKpbITHH Tpy-
na-B opranax.
JIHCTEPEJIJIE3
B eCTecTBeIIHblx yCJIOBHHx JIHCTepeJIJIe3 cpej[H fJIOTO51/lHblx }KH-
BOTHbIX 0TMetleH y JIHCHU (KpoMBeJIJ1 H apyrHe, 1939) H y co6aK
(LIenMeH, 1947). BoJIe3Hb npOTeKaeT, KaK T51)KeJIOe nOpa}KeHHe IZeH-
TpaJIbHOI-I IIepBH013 CHCTeMbI, H OHeHb noxo xa Ha MOJIHHeHOCHyIO
(pOPMy HyMbI nJIOT0HJjHbIX. HH(peKuH5l paCnpOCTpaHHeTC51 HCKJIIOLIH-
TeJIbHO 6bICTpO H T-Iepe3 HeCKOJIbKO TiaCOB 6oJIbIJIHHCTBO 3a6ojIeB)nIJX
) (HBOTHbIX, OCo6eHHO MOJIOJjHHK, rH6HeT.
B OTJIH4He OT HyMbI, JIHCTepeJIJIe3 y co6aK (FpexeM H apyrfe,
1940; II. M. CBHHUOB, 1946) npH BHYTPHBeHHOM H BHyTpHMbIHIen-
HOM 3apa)KeHHH npOTeKaeT, KaK KpaTKOBpeMeHHb1II Status febrilis.
MbI CHHTaeM, LITO BO Bcex CJIytIaHIX MOJIHHeHOCHOrO Te'IeHHH LlyMbt
nJIoT05IJjHbIX y JIHCHR H co6aK, ConpOBO)KJjaloluerocx BblpaxceHHOIi
HepBHOI3 KJIHHHKOf1, Heo6xoJjHMo HCKJIIOLIHTb JIHCTepeJIJIe3. flojlo%H-
TeJlbnble pe3y.nbTaTbl 6aKTepnoJloritlecKoro HCCJIeaOBaHHH M03ra
naBHIHX )KHBOTHbIX (BbIceB Ha netleHOtIHO-rJI0KO3Hble cpeJjbi) H 3a-
pa)KeHHH JIa6opaTOpHbIX )KHBOTHbIX n03BOJISIK)T OTJ[H(j4epeHljHpo-
BaTb HYMN HJIOTOHJ(HbIX OT JIHCTepeJIJIe3a.
03EHA
03eHa HJIH 3JIOBOHHbII-I HaCMOpK, BO3JjyHIHO-KaneJIbHaHI H KOHTaKT-
Ha51 HH(J)CKIjHSI, BbI3bIBaeTCq KOpOTKOFI, IIenoj BII3KHOfI rpaMOTpHIja-
TeJlbxoK naJlogKof Klebsiella (Bact.) ozaenae Abel (1893), naTOreH-
HOIi JjJIH co6aK H LleJioBeKa. BoJIe3Hb HMeeT JjJIHTejibHoe XpOHH-
LIeCKoe TetleHHe. OT LIyMbI 03eHa OTJIHLIaeTcH OTCyTCTBHeM KOH'b!OHK-
THBHTa, jierOLIHbIX, KHIHetIHbIX H HepBHbIX 5IBJIeHHII.
^HPOIIJIA3M03 COBAK
IIpH BbICOKOf TeMnepaType (40,5-42,0), paccTpoJCTBe }KeJlyJjoti-
HO-KHHIeHHOrO TpaKTa, KepaTHTe, KOH'bIOHKTHBHTe fHpOHJIa3MO3
HHorjja npHHHMaeTCH 3a tJyMy. MHKpOCKOnH31 Ma3KOB KPOBH n03BO-
JIHeT HCKJIIOTlHTb nHpOnJIa3MO3. OJjHaKO B xpoHHtIeCKHX cJiyHaax
12*
179
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B KpOBII Tpyl[HO o611apyMKIITb napa31ITOB II TorAa 1IHar1IO3 yCTanaB-
JIHBaCTCSI 110 CyMI,IC KJIHIIHTICCKI[X H 0nn30OT0JI0u I IeCKHX noKa3a-
TeJIeK.
,L1,.nn uH(j(pepCHunaJibxoro RHarI103,1 H3BCCTHyIO opHeIITHpOBKY
j[aeT KJ1TI00ICCKHH anaJIH3 KpOBII. CorJIacHO aaHlfbIM H. H. Op.nOBa
(1)27), yBe3n'IeIIIIC HCFITpo( 1LnOB (jo 97%) H yMCHbWCIIHe aiimq)O,-
uHTOB (JO 1%) XapaKTepHO u.I2 LIyMbI C06aK. HpII nnpoIlJIa3MO3e,
HanpOTHB, XapaKTCpIIO yMCHbHICIIIIC HeHTpo(JHJIOB H yBCJIH'IeIIHe
JIHM(IJO1HTOB (A0 59%). XapaKTepHO 113MCHeIIHe Kpacnou KPOBH. HpH
gyMe gpHTpOUHTbI B IIopMe HAM HCCKOJIbKO McHbnle. HpH nHpOHJIa3-
M03e KOJIHgeCTBO reMorao61ma 11 3pnTpOLHTOB PC3KO yMeI[buiaeTCSl
(AO I M.W. B I MJI).
,UJIo xpoHH'-ICCKOFO rIHponna3M03a xapa {Tepna cHJIblian alleMHgi
(nOJInxpoMaTO3lO, nOfIKHJIOuIIT03, II 11130 11TO3 H 3pCTpO6JIacTbl),
HpH iyMc }KC oiia C,TTa60 Bb[paMKena HJIH BOBce OTCyTCTByCT.
B JIHTepaType OfIICal{O CMeln3HIIOC Tetlellue iyMbl H nnponJla3MO-
3a y co6,1K. B TO }KC BpeMSI eCTb J.HIIIb1C, 0TO BIIpyC ByMbl 11310TOnA-
HbIX-3HT3F0IIHCT iliIpOHJIa3M. r. C. J3,1COXOB (1947) nOKa3OJI, OTO
Co63Kfl II LuC11OK, nepe6oJICBLLnIe n11pOll31a3M03OM, npri nocneJi,y1Olljen
BCnhIIIIKC. 'lV'MbI I[C. 11aJIII peull,111Ba.
Ho bnn3PHxy (1951), KJ1HIH1'ICCKa[T KapTHIIa H naTo.norornCTOJ10-
FH'ICCIOIC I13MelIennn B KJIeTKax II TK311SIX M03ra npH TOKC0IIJIa3MO3e
n 1y\IC IIJIOTOA;iilblx II3CTOJI1KO M0p(I)0.1OrH'IeCKH n ICIITH011b1, 'T0
IIC06XO.U1MbTM YC,TIOBII('M JIJTH JjII(1)(1)epe111aJlbn0r0 J1HarIlO3a
SIBJIIICTCII BbUike3ICIIHC B036yJ1IITCJIH.
nAPATWW'G COBAK
Ho San llblM M. E. ABBaKyMOBa H B. M. Boro,nlo6oBOFI (1938),
B. H. I Ia3apoBa (1940, 1956), E. C. LIepxaCCKOro (1954), B OTJIHOHe
OT'IyDIbI, naPMII(})OM 3aOOJICBaI0T'Iame BCCro 1-3-'l'ICC'I'Inble LueHKH
B JIeTliee BpCMB rota. HpcApacnoJlaraloLuHC (jJaKTOpb1: cMena 3y60B,
re.iKa 4epe3 XOPbKOB B Ka4eCTBe BaKL[HHbI HPOTHB 4yMbr
y JIHCHU H Co6aK. 1'13 npHBHTbIX 25 H1,eHKOB 3a6o,TIeJIH H na.IH
TOJIbKO 4. BaKUHHa npeACTaBJISIeT co6o i BbICyLueHHyfO ceiie3eHKy
XOpbKa. 1'pHH, KapJ1COH H apyrHe (1940) ycneLLIHO HMMyHH3HpOBajrH
3TOr3 BaKUHHOrl OKOJIO 1000 C06aK B BO3paCTe OT 12 HeaeJlb Jjo 5 JIeT,
OJ(HOKpaTHO HOJj KO>KY B Ja03e 2 Mr Ha 1 Kr >KHBOI'O Beca. OAHaKO,
no IIlJiOTTray3py (1946), fOJIO>KHTeJlbHbie pe3yJlbTaTbI JZaIOT TOJIbKO
60AbHIHe a03bI BaKL[HHb1 - He McHee 15 Mr Ha HH'beKUHK); Jj03b1
B 2,5 H 7,5 Mr He npeaoxpaHRJIH co6aK OT LIyMbI.
PeaKuHR Y BaKW-IHHp0BaHHbIX cO6aK HaCTynaeT,- yKa3bIBaIOT
rpHH H apyrHe (1940) ,-4epe3 5-7 aHei'I noc. ie npHBHBKH H npoTe-
KaeT Hanoji.o6He CnOHTaHHOFI 4yMbI C nOJ1.'beMOM TeMnepaTypbl H
JIerKHMH KaTapaJlbHbIMH SIBJIeHHHMH.
BnocjieaCTBHH rpHH (1945) noxa3aJl OTCyTCTBHe pa3JIH4Hrr B
HMMyHOreHHOCTH LHTaMMOB, npotueALHHx 57, 63 H 69 rlacca>Ke i 4epe3
XOpbKOB. HaH60J1ee HanpH>KeHHbI1I HMMYHHTeT K 4yMe y co6aK H1CTy-
naeT 4epe3 2 Mec ga. HeCKOJIbKO HjeHKOB, BaKLLHHHPOBaHHbIX 3a
5-6 HeaeJlb aO KOHTpOJIbHOI'O 3apa)KeHHSI, najIH. B 3TOM >Ke roay
B He6JIar0n0JIy4HOM XO3HNCTBe 6bIJIH BaKUHHHpOBaHbi 157 co6aK, HO
3a60JleJ H qyMOFI TOJIbKO 8 co6aK, B TO BpeMH KaK H3 98 HeBaKLjHHH-
pOBaHHbIX C06aK 3a6oJIeJIH 96 (['pHH H KapJICOH, 1945). XOT51 aBTO-
pbr H CAeJiaJIH 3aKJII04eHHe, 4TO BHpyC 4YMbI FIJIOTORAHbIX var. putorius
aBHpyJIeHTeH H 6e3BpeaeH JGTIR co6aK, HO HX >Ke CO6CTBeHHble aaHHbie
YKa3bIBaIOT Ha onpejjeJIeHHyro Ke BaTCOHOM (1939), B03pa>KaBIUHM npoTHB ee npHMeHeHHR B 611a-
rOHOJ1y4HbIX JIHCOBOJj4eCKHX X03HHCTBaX KaHaJjbl. B CBH3H C 4aCTbIMH
CJIygaRMH TH)KeJIbIX nOCTBaKUHHaJIbHbIX 3a6oJIeBaHHr3 H najje>Ka
HpHBHTbIX CO6aK OT 4yMbI rpHH (1945) nOJ[Bepr CHeUHaJIbHOMY H3y-
4eHHIO TepMH4eCKHe peaKLUHH y co6aK, npHBHTbIX BHpyCOM 4yMbI
n.JIOTORJjHbIX. BHpyC, naCCHpOBaHHbIcI iepe3 XOPbKOB 54-63 pa3a,
KeHHH> . HaKanJIHBaBLHHecR JjaHHbre o npHMeHeHHH BBKUHHbI
17pHHa nOKa3aJIH, 4TO ee 3(J(I)eKTHBHOCTb 6bljia npH6JIH3HTeJIbHO Ta-
KO11 we, KaK H ApyrHX BaKUHH, He3aBHCHMO OT TOFO, npHMeHHJICH JIH
BaKUHHOBHpyCHbII1 McTOJj OPHBHBOK HJIH >Ke OJjHa y6HTa5I BaKUHHa
(PH3ep, 1950). Tax, HanpHMep, )KOH (1947) noxa3aJI, 4TO H3 BaKLjH-
HHpOBaHHbIX HO rpHHy 300 co6aK 3a6oJIeJIO 4yMOrI 6,2% H naJro 5%,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
a 113 HPHBIJTbIX no IIenjgToy it JeIiKH1Iy -- 000TBeTCTBeHIO 9,8% H
7,1 ?;,. ITOCTCHCHHO IlaKarIJIHBajICH MaiepIIa.3 it o6 H11(4)eKUHoHHocTH
BaiiuIIHBi 1-pima ,aim co6aK. 3j}Ke-r (1947) coo6luiui o MHOrHX CJly-
,[,i2x rn6ejin OT LlyMbl BCeX IIplBHTbIX B3KIIH11OH FpHH3 3J1.OpOBbIX
Co6aK. KaI1TOp03Ht1 (1947) rIPHMO HHcwrl, '-ITO .
He6Taronpnarnbie pe3ynbTaTbl OT6leoaJiH &iiMep H J[pyrne (1948),
0006nj1I3111IIe, LIFO 113 rlpo(IJHJiaKTliiieCKH ripHBH'rbIX 874 co6aK 10,3%
cpa3V 3a6cmic:mm 'IVMOIHI B pe3VJlbTaTe IIpIIBi3BKII, 3,8%-IICCKOJIbKO
i[03;uiee, a 4,49b norn6JIIT.
Fop H upvrne (1948) HOKa3OJIH, 'ITO BO (1)paiiuIIII BOKI[IIIIOII
I prlna, HpnrOTOB.ieHllOil 113 Brlpyca 60 nacca:a a 'Tepe3 XOpbKOB, 3a6o-
1CBaJIH 12-15% Ba KUHIIIIPOBaIIIIb1X co6aic, a rlaj e71{ JjOCTIdranl 10%.
Bocce (1948) HorLTBepjuJI, 'ITO npnMeIl eMaa BO (Ppanurn BaK-
I1;rIIIa ripoTHB LIyMbI y cooaK IOTOBHTC51 H3 HO)L.TIIHIIOI'O aMepHKaH-
CKOrO 1111OMMa BlipvCa, II CCHPOBaHHOr0 I'pnnoa Hepe3 XopbKOB. 011
IIpiiue:1 Jjalnlbie, 'ITO IIpHBHBKH BaKKHHOII 1,pHHa IIJIII Bb13bIBa1OT LIyMy
t %m iKC co6aKll lie npHTO6peTalOT IIMMyllnTCT.
IJICHneii (1949) B CJIv'Ia51X TSI)KeJIOH peaKUnn Ha CIPHHBHBKH rpH-
na PCKOMCI1,gY0T IIOBTOplIOe 1113e) 1IHe BaKuHHbl.
LITnpOKOe BHejjpemIC BaKUHHbI TpHIIa B CILIA lie conpoBO}KJja-
,TOCb HCO6XOJjUMbIMIi KJIHHHKO-3nn300TOJIOFII iecKHMH Ha6JIIOJjCHHSIMH.
I1o3TOMy, HeCMOTP1 Ha MI-IOI'OLIHC.TiCHHble enrim IbI npaKTITLIeCKHX Bpa-
'ICli, TOJIbKO HO HICTeOIeHHhl MIIOI'IIX JIeT H TJIaBIIbIM o6pa3OM tie
B CLHA, a B FepMaHTIn H BO OpanuHH, 6blJIr[ ony6JIHKOBaHbl JjaHHble
o6 IH1(PeKIwOHHOCru it CTa6oi 3(0(j)CKTHB1IOCTH BaKUHHbI I'puma. B
CBH3H C 3THM B HHOCTpaI1HOH riwrepaType HOIIBHJIHCb CTaTbH, B KOTO-
PbIX Bonpoc O CBOHCTBaX BaKUHHbI ['puma TpaKTyeTC51, KaK 3anyTaH-
liblu. OJ[HaKO B CBeTe Ra1111bIX COBeTCKHX IIMMyIIOJ1OFOB (H. (D. 3Apo-
;(OBCK11H, 1950, B. IT. 1 HMaKOB, 1950) o6 OTPHUaTeJIbHOM BJIHSIIIHH
iieHOJIHoueHllbix aIITHre1I03 14 HC3aKOHLICHHblX rIpIIBI-IBOK Iia HMMyHO-
6HOJIOrngecxyto fCPCCTpOHKy HPHBHTbIX KOHTHHrerITOB, BOnpOC COBep-
uieiiuo icon, H6o ripeaCTaBJTTIeT aacop611POBaIHbIR IIa I-HupooKHCH aJrloMii mHSI
BHpyc LIyMbI fJIOTOHJjHbIX var. putorius, 3aMOpO}KeHHbII1 n BbICyrIICH-
Hbifi HOJj BaKyyMOM. CpOK rOJjHOCTH 8 Mec. BaKUHHa 1Tp1-11OTOBJIReTCSI
H3 ceJIe3CHKH H M03ra XopbKa, 3apa}KeHHOI'O BHpyCOM, npoureJUIIlHM
12-18 riacca>Keil 1-repe3 XopbKOB. TKaH:H XOPbxa paCTHpaIOTCH
C JjrrcTIJJIJI11pOBailII0 i B0,10fi aO cycneH3HH, co jep}Karueu 160 Mr TKa-
HH B I MJI; CyCHeH3H5r Ue1ITpH()yrHpyeTC5I, (IHJlbTpyeTCH LIepe3 (pHJIbTp
36ITua It pa3BO,1WITCH B 2-8 pa3. FH,1),pOOKHCb aJIiOMHHHR IOTOBHTCI
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113 aJIIOMHHHeBb1X KBaCUOB. Ee HOJIHaH aACOp6UHOHHaR CHO006HOCTb
He npeabl[HaeT 80 Mr HCXOAHOH TKaHH Ha 1 MJI. Ajjcop6uuR ocyLUeCTB-
JISIeTCH CMeHIeHHeM H 10-15-MHIIyTHbIM IIIyTeJIJIHpOBaHHeM paBHbIX
uaCTeII BHpyCHOl cyCHeH3HH H rHApOOKHCH aJIIOMHIIHSI. IIOJiy'iaeTCSI
KOJIJIouJ aJIbHbIII KOMnJIeKC, KOTOpbIM HpH HOAK03KHOM BBeaeHu14 I MJI
B TetlenHe 2 MeC. BHpyJIeHTeH AJIJ XOpbKOB. BBeAeHne KOMruIeKca, Co-
jjepxcaiuero 20 Mr HCXOAHOH TKaHH B 1 MJI, YAJIHHSieT HHKy6auHOHHbIII
nepHOA y XOpbKOB AO 10 AHeu. KoJIJioHAaJIbHbIft KOMHJIeKC TepReT
BHpyJIeHTHOCTb AJIR XOpbKOB noCJle 3aMopa}KHBaH119 H BbICywHBaHH51
Jjo 6eJiOBaTOII nOpOIIiOKOo6pa31-IOM MaccbI, JIerKO 3MyJIbrHpyeMOH
B BoAe.
Be3Bpe,aHOCTb H HMMynoreHHble CBOIICTBa BaK1iHHbI I'op3 yCTa-
HOBHJI B OnbITaX Ha 150 XOpbKaX H 25 co6aKax. 11pH HOAKO}KHOH
npHBHBKe 2 MJI BaKuHHbI, co, ep}KaHjecI 40 Mr HCXOAHOR TKaHH,
HMMyHITeT HaCTynaeT ~iepe3 10-12 aHeii H aJIHTC5I HeCKOJIbKO Mec I-
ueB. r103AHee Fop3 (1947), XOT5I H npH3HaJI, IITO ero BaKH,HHa
, TeM He McHee yTBep}K),aeT, TITO 3a6oJleBaxne 15% H3
1717 npHBHTbIX Co6aK o6yCJIOBJIeIIO BbICOKOI4 BHpyJIeHTHOCTbIO HaTy-
paJlbHorO BHpyca 9yMbI co6aK.
B o6HjeM, nOJIO}KHTeJlbHO OT3bIBaIOTC5I 0 BaKWHHe Fop YJIbpHX
(1950), a TaK>Ke MaJuie (1949), XOT51 ao 56% ripnaHTbIX co6aK
.BHOCJIeJLCTBHH 3a6oJIeJIH.
TeopeTHteCKHe nOCTpoeHHSi 1'Op3, npH3BaHHbie 06'b5ICHHTb npHTIH-
HbI TO aBHpyJIeHTHOCTH H HeHMyHoreHHOCTH, TO HH(IeKUHOHHOCTH
IIpej[JIO}KeHHOIi HM BBKUHHbI, npOTHBOpe'IHBbI.
CornacHO Ha1IIHM 3KCnepHMeHTaJIbHbIM aaHHbIM, 3TH fPHUHHbI
Jle}KaT He CTOJIbKO B 1JIOCKOCTH I) H3HKO-XHMHLIeCKHX 3aKOHoMepHO-
CTeII, KBK 3T0 no.laraeT rop3 (H60 HH rFApOOKHCb aJIIOMHHHH, HH
BbICyIHHBaHHe He HHaKTHBHpyIOT BHpyca 'IyMbI), CKOJIbKO B 113MeH-
14HBOCTH 6HOJI0r1'IecKHX CBOIICTB aIaafTHpOBaHHOrO BHpyca H B peaK-
WIH Ha Hero MaxpoopraHH3Ma. 06 3TOM }Ke CBHAeTeJIbcTByioT He-
yjja4Hble OnbITbI FpyHHeTa (1949), no BaKUHHauHH XOPbKOB BHpy-
COM, agcop6HpOBaHHbIM IIa rIApOOKHCH aJIIOMHHH51. KaK H CJIeAOBaJI0
O}KHJjaTb, rHApOOKHCb aJIIOMHHHH He HHaKTnBHpOBaJIa BHpyC H y 16
13 18 BaKUHHHpOBaHHbIX XOPbKOB B03HHKJIa npHBHBHaJi 'IyMa.
3M6pHOH-BaKIUHHbI
Ilonu(3a,zeltTnast aM6puoH-eaKt4utta. (D. H. OpJioB (1922) nepBbIH
,o6paTHJI BHHMaHHe Ha 6oJIbluyIO HMMyHOJIOrHTIeCKyIO BapHa6HJIb-
HOCTb BHpyca LIyMbI HJIOTOSIJjHbIX H yxa3aJl Ha OrpOMHOe npeHMy-
IueCTBO BaKUHH H3 MCCTHbIX HITaMMOB Bnpyca.
K HaCTOSInjeMy BpeMeHH HaKOnHJ1aCb y}Ke aOBOJIbHO 3HatIHTeJib-
Ha5l JIHTepaTypa (KHyp-MypaTOB, 1940, 1952, LlepxaccKHII, 1948,
1950, 1954, YJIbpHX, 1950, PH3ep, 1950, TIapHH, 1954), aBTOPbI
KOTOPOH yCMaTPHBaIOT B nJiiopaJiHTeTe BHpyca '-IyMbI rIJ10TO51AHbIX
OAHy H3 OCHOBHbIX npH'IHH TIaCTOIi He34I4eKTHBHOCTH npOTHBO'-IyM-
HbIX BaKUHH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
/TOT BbIBOA H nO6yAHJI HaC BnepBble 3aHRTbCH npHrOT0BJ1eHHeM
nOJIHBaJIEHTHOH BaKUHHbl H3 HITaMMOB Bnpyca, BbIJ(eJICHHbIX B pa3-
HbIX reorpa(bntieCKHx 30Hax H OTJIHqa10LI xc5I Me}K,gy C06oi1 B HMMy-
Ho6HoJIOrHIiecKoM OTHOLHeHnH.
MbI 000T8BHJIH nepea Co6Oi%I 3a)jaTy CO3AaTb BaKUHHy, CHatiajia
HHaKTHBHpoBaHHyIo (1948), a 3aTeM }KHBYIO (1949), KOTOpaH coo6-
LUaJIa 6bI UJIHTeJlbHbIR H Hanpft}KeHHbIi'I HMMYHHTCT npH oAHOKpaTHOl3
HpHBHBKe H He6oJIbLHHX A03HpoBKaX.
Pa3pa6OTaHHbIi3 HaMH cnoco6 aaanTauuH Bnpyca TIyMbI rIJIOT05IA-
HbIX K PK9 nyTeM nepeKpeCTHOFI HHOKYJIHuHH Bnpyca OT co6a,4bnx
IUeHKOB K PKD H OT PKD K LUeHKaM H T. J. npHBeJi K H3MeHeHHIo
HPHPOJjbl Bnpyca, K ero aTTexyauHH: n09TH fOJIHOIi noTepe BHpy-
JIeHTHbIX CBOKCTB, npH coxpaHeHHH HMMyHOI'eHHbIX. Ha OCHOBe noJly-
tIeHHOrO HO 3TOMy cnoco6y (1)HKCnpOBaHHOro Bnpyca HaMH npeano-
fKeHbI nOJIHBaJIeHTHble HHaKTHBHPOBaHH3 I H )KHBaH (ocJIa6JieHHa5I)
rHJ[pOOKHCbaJIIOMHHHeBbie 3M6pHOH-BaKUHHbI 9yMbI fJIOTOSIAHbIX,
coaep}Katuwe pa3JIHqHble B HMMyHO6HOJIOrHTIeCKOM 0THOLHeHHH
HCXOAHb!e HITaMMbI Bnpyca (E. C. LIepKa(-CKHI3, 1948, 1950, 1951,
1954, 1956).
,JJIH npHr0TOBJIeHH51 BBKUHHbI MbI npHMeHAJIH 3M6pJIOH-LHTaMMb!
Bnpyca 9yMbI, CO CTa6HJibHO Bblpa}KeHHbIMH HMMyHOreHHbIMH CBOcI-
CTBaMH H THTpOM BHpyJIeHTHOCTn, Bb13bIBa1OUIHM rH6eJIb HJIH xapaK-
TCpHble H3MeHeHH9 B I!peaeJiax Ao 60% PKD B B03paCTe 6-7
,I);HecI IIepe3 18-120 9aCOB noc ie BBeAeHH:3 0,1 MJI 25% cycneH3nH
BIIpyCHOrO MaTepHaJIa. 1-lpn 3TOM CMeCb pa3JIH'-IHbIX B HMMyHo6HOJI0-
I'LI4eCKOM OTHOLHeHHH THnOB (HITaMMOB) Bnpyca BBOAHJIH B OJWH H
TOT }Ke PKD HJIH HeCKOJIbKO pa3HbIX LHTaMMOB - B pa3Hble TKBHH
0AHOI'O If TOrO >Ke PKD, HJIH, HaKOHeu, TlaLUe Bcero KOHUeHTPHPOBaJIH
pa3Hble THnbI (IIITaMMbI) Bnpyca B pa3JIHWTHbIX PKD H cMeLHHBaJIH
HX 3aTeM B onpeAe.ieHHbIX COOTHOLHeHH51X y: {e B npouecce npnrOTOB-
JIeIIH5I BaKUHHb!. BaKUHHy rOTOBHJIV 113 Bcex TIaCTei (KpoMe 6eJIKa H
}KeJITKa) norH6LHnx 3M6pHOHOB HJIH 3M6pHOHOB, HMeIOLuHX Bblpa}KeH-
[Ible cneu q)HUeCKHe H3MeHeHH1 no c,nexyKUUeH nponncP: 25% cyc-
neH3H5I BHpycnoro MaTepHajia Ha (j)H3paCTBOpe - C THTpOM AJI5i
PKD He Menee 0,1 MJIXIO -3-50%; rHJjpOOKHCH aJIIOMHHIIK Ha (JOC-
q)aTHOM 6y(epe npH pH=7,2-7,4-50%. KpoMe Toro, B BaKUHHy
BBOJ(SITCH (JopMaJlbxerHI : OT 0,01-0,03% (iKnBax oc.Ia6JieHHa5I Bax-
UIIHa) ao 0,1-0,3% (HHaKTIIBHpOBaHHa51 BaKUHHy) H neHHuHJIJIHH-
1 000 000 ME Ha 1 if. BaKUHHy BbIJjep}KHBaeTCH 10 gHeI1 B XOJIO-
AHJIbHHKe npn 6?, npOBepfieTCH Ha CTepuJIbHOCTb, 6e3BpeJjHOCTb,
HMMyHoreHHOCTb.
PeaKUH51 Y npHBHTbIX }KHBOTHbIX Ha BaKUHHy, KOTOpaH HCCKOJIbKO
CYIJIbHee Ha )KHBy1O OcJIa6JIeHHy10, ileM Ha HHaKTHBHPOBaHHYIO BaK-
UHHy, Bblpa}KaeTCR 06bIgHO B AeHb npHBHBKH HJIH Ha CJieayIoLUH}i
AeIIb B KpaTKOBpeMeHHOM HOBbILneHHH TeMnepaTypbl (AO 1?) H HHOraa
6bICTpO npoxoagLuei3 BHJIOCTH H yMeHbWleHHH anneTHTa. L4epe3
3-5 AHef B cpeJinelvt y 60-70% npHBHTbIX )KHBOTHbIX OTMet1aeTC5I
noBbILIIeHHe TeMnepaTypbl TeJIa .110 1?, peAK0 Ao 1,50, np0J1:0JI}Kaio-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
t?
39,5
jA 28 29 30 31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Mapco 19 9 Anpena 1949a
PHc. 37. TeMneparypllasl peaRuHH Ha BaKIWHy.
MeecSi He 60Jlbnle O1(HOFO IIHSI (pxc. 37). Y OTAeJIbHbIX )KHBOTHbIX
B McCTe BBeaeHHH BaKuHHbI HHOrAa o6pa3ylOTCH HH(~HJIbTpaTbI H
a6CUeccbI, tITO MO}KeT HaPYLIIHTb AlopaHTHOe aeHCTBHe BaKuHHbI H
CHH3HTb 3 4eKTHBHOCTb npHBHBKH. I4cCJIeAOBaHHI 8 cepni BaKuHHbI,
BbI3BaBLIIHe y OTAeJIbHbIX co6aK a6cUeccbI, nOKa3aiIH HX 6aKTepHoJIo-
rI-ITIeCKyio CTepHJIbHOCTb. npOBeAeHHbie npoc eccopoM B. 1. IIBaHO-
BbIM rHCTOJIOrHieCKHe Hcc.neAOBaHH5f TaK}Ke AaJIH OTPHUaTeJIbHbII-I
pe3yJlbTaT; CTpOroe co6JHo.r eHHe acenTHgeCKOrO pe}KHMa rPHBHBOK
YCTpaHHeT o6pa3OBaHHe a6cuecCOB. LITO6bI HCKJIIO'IHTb tlpe3MepHOe
pa3Apa>Kaioluee aefCTBHe OT BBeaeHHSI npenapaTa B OAHO McCTO,
MbI peKOMeHAyeM BBOAHTb BaKLLHHY He60JIb1IHMH IIOpUHHMH, nOCTe-
neHHO BbIABHrax HH'beKUHOHHyIo HFJIY H KaK 6bI HH6H6Hpysl o6JIacTb
npHBHBKH.
noHBJIeHHe H HapaCTaHHC cneun(J)niiecKHx allTHTeJl B KPOBH
51BJI5ieTC$T OjjHHM H3 Ba3KHbIX rioKa3aHHl3 HMMyRO6HOJI0rHtieCKOH
nepeCTpOI1KH opraHH3Ma. fIpOBepKa aKTHBHOCTH CbIBOPOTKH KPOBH
}KHBOTHbIX, HMMYHH3HPOBaHHbIX nOJIHBaJIeHTHOI-i 9M6pHOH-BaKIjHHOI3,
OCYLUeCTBJIHJIaCb B peaKLIHH reMoarrJIK)THHauHH H ee 3a.ep}KKH H
I7POBOAHJIaCb napaJlJIeJIbHO C OnbITaMH Ha 6e3BpeAHOCTb H KOHTpOJIb-
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BHpyca. Rim onpeAejieHHSI HapaCTaHHA npOTHBOT-YMHbIX allTliTeii
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LIIHHCTBe CJIytIaeB He CHH}KaeTCSI H Aaxce HeCKOJIbKO noBbluiaeTCA.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ca}Ka, npHBeaeHHble Aim HpHMepa Ha pHC. 39, xapaKTepH3yIOT
HpHH51TYIO HaMH cxeMy KOHTPOJI51 a(4(peKTHBHOCTH BaKL1,HHbI, ee 6e3-
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npITNKJjy BBeJIeHHeM
BHpyca H cblBOpoTKH: 30 MHH.- 1 vac, (,L ajiJIHHr, 1934), 3-12
uacOB (BnJibKHHCOH, 1933), 24 tiara (Fop H apyrme, 1936, Pycco,
1937, Jle.nanuD, 1938), 24-48 tiac. (Perenoc, 1935, FeHrep, 1939),
48-72 tiara (JIITTJIb, 1934) H T. R. PereHOC peKOMeHJIyeT npHBHBaTb
LUeHKOB B BO3paCTe uo 1 roila B JIBa npHeMa, c nepepblBOM B 14
AHeFi. I1pHBHBKH npOH3BO1STTCH HO1KO>KHO, BHyTPHKO>KHO HJIH BHyT-
pHBeHIIO - CHatla.na 10 Mr BHpyJIeHTHOII CyXOl3 TKaHH ceJle3eHKH,
a 3aTeM 20 M,R IIeKOHUeHTPHpOBaHHOI3 HJIH 4 IvIJI KOHueHTpIIpOBaHHOli
rHnepHMMYHHOH CbIBOpOTKH.
JIHTTJIb (1934), 1eKrep (1941), Fo(~MaH (1943) H upyrHe cnpa-
BeJI.rInBO yKa3aJ1H, 4T0 J1ByXcpa3Hwi npHBHBKa KpaHHe HeyJlo6Ha AJIH
HHJIHBnLIyaJIbHbIX BJIaJIeJIbueB co6aK.
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3TOT cnoco6 npe1JIO>KHJIH JIHTTJIb, BaTcoH H )IeHTU (1933),
HOJIVtIHIHIHe KOHUeHTpnpOBaHHyro FHHePHMMy11HyIO CbIBOpOTKy, aK-
THBIIyIO B OTIIOHIeHHH BHpyca H B036yaHTeJIefI BTOPH4IHbIX HH(I)eK-
uHi. OJIHaKO Pocc (1934) B npOBepO'-IHbIX orlbiTaX Ha XOpbKaX noJly-
HHJI OTpHUaTe.7bllble pe3yJlbTaTbl.
Bajlbrapeurli (1933, 1934) HOCTaBHJI pAu OnbITOB JaBYKPaTHbIX
npnuHi3oK M03rOBhIMH BaKUHHaMH no (I)HHUH H IIyHTOHH H aHTH-
nnoreHHON CbIBOPOTKH no MauuyKH. Pe3yJIbTaTbl 6bIJIH npOTHBOpe-
1HBble.
BAKLtHHAILHA JIHCHLL, HOPOK, EHOTOBHAHbIX C06AK
H C060JIEFI
BaKUHHaUHS1 JIHCH[
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pacnpocTpaHeHHe Ha 3BepOBO)'leCKHX 4IepMaX B Kaliaae, CILIA H AP-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cripailax. I1onynIHpHbIM cpeacTBOM RBJIReTCR OnHCaHHaH Bblme )KHBaR
BaKUHHa FpnHa, npeACTaBJ15HOLua5I co6oli BHpyc 'IyMbI JIHCHL[, aAan-
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y JIHCHu JlerKoe nepe60JIeBaHHe, 6e3 CMepTeJIbHOI'O ncxoj a, H C03AaeT
noc ie 3TOFO HanpHIKeHHbII1 HMMYHHTeT (FpHH H Kap.mCOH, 1939).
B 1939 r. eio 6bIJIO npHBHTO 20 TbIC. JIHCHu, XOTH BaTCOH (1939) H
.B03pa}KaJi npOTHB 3TOI3 BaKUHHbI, YKa3bIBaH Ha OnaCHOCTb ee npHMe-
HeHHH B 611aronojiy bIX X035IHCTBaX. PeKOMeHAOBa.IOCb BO H36e-
}KaHHe npHBHBHOIi TIyMbI OAHOBpeMeHHOe BBeAeHHe BaKLUHHbI H CbIBO-
POTKH. O,LHaKO, no FpHlly H KapJlcony (1945), BBeieHHe oAHOII BaK-
UHHbI 3("eKTHBHee, He}KeJIH BaKUHHbI H FHnepHMMYHHOIi CbIBOPOTKH.
TaK, H3 8 TbIC. JIHCHLI, HaXOAHBHIHXCH B He611aronOJIYqHbIX XO3RIi-
CTBaX, OAHOIi HOJIOBHHe 6bIJIH BBeaeHb1 BaKIZHHa H CbIBOpOTKa, a apy-
TOIi OAHa BaKUHHa; BCnbILHKa LIYMbi 6blJla I1 HOCTaHOBJ1eHa TOJIbKO
y JIHCHL[, npHBHTbIX no 2,5 MA BaKUHHOIi, a CMepTHOCTb COCTBBHJIa
3% nPOTHB 75%.
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yCneIHHO npHBHTO CBbILLIe 200 TbIC. JIHCbHX LueHKOB, Aajio fOBOA
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1-IOBaHHO yTBep?KAaTb,. 1ITO McTOA I'pHHa ce6H nOJIHOCTbIO onpaBAaJi
H HBJIHeTCR o61uenpH3HaHHbIM Ha 3BPQoc )epMaX B CI.I.IA H AHrJIHH.
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BaKgHHbI FpHHa H IHHPOKOM npHMeHeHHH HPOTHB qyMbI JIHCHu Apy-
THX BaKWHH. Iexrep (1940) ycneiuHO HMMYHH3HPOBaJI 125 MOJIOAbIX
cepe6pHCTO-LIepHbIX JIHCHII, y6nTOIi npOTHBOqyMHO13 BaKUHHOI3, a Kox
H Ap. (1941) CHMYJIbTaHHO npHBHJIH B 3apa)KeHHOM XO3 If CTBe 35
cepe6pHCTO-tiepxbIx JIHCHL; JIHCnubI Bce BbI)KHJIH. 0 xopoHlHx pe-
3YJIbTaTaX npHBHBOK 4JOPMOJIBaKUHHOIi H3 CeJIe3eHKH coo6mHJI AJi-
JIeH (1941). HeCKOJIbKO TbICHtI JIHCHLI ycneinHo 6bIJIH fPHBHTbi (pop-
MOJIBaKLInHOH, npHI'OTOBJIeHHOIi H3 napeHXHMaT03HbIX opraHOB JIHCHLI,
IIaBLLIHX OT iIYMbI (KHHTCKOTT, 1946; OTTO H Max UepHHA, 1946 H
Ap.). B HacT0RH1ee BpeMH B CILIA, KaHaJIe, CKaHAHHaBCKHX CTpaHax
AJIH BaKUHHaLLHH JIHCHLI, H neciioB HJHPOKO H ycnemmHO n;pHMeHHeTCH
cyxaR 3M6pHOH-BaKL1,HHa, coAepxcaluaR BHpyc, aAanTHpOBaHHbIii
K PK3. BaKUHHa BBOAHTCR nOAKO}KHO B A03e 1 MJI H Co3AaeT HMMy-
HHTeT vepe3 10 AHeli. AHaiiOFHqHaH nOJIHBaJIeHTHaH 3M6pHOH-BaKuH-
na LlepKaCCKOFO orpaHHUeHHO npHMeHHJIaCb B CCCP Ha .T1HCaX, OHa
BHOJIHe 6e3BpeAHa, AaJIa o6HaaexcnBaioLune pe3yJIbTaTbI npH ee
BHyTpHMbILne4IHOM BBeAeHHH B AO3aX 1,5-3 MJI H B HaCTOHaLee
BpeMH HaXOAHTCH B CTaAHH npOH3BOACTBeHHOII npoBepKH.
B JIHCOBOA4eCKHX XO35I CTBaX CCCP HCnbITblBajIaCb TaK}Ke Kpo-
JIHLIbH MO3FOBa5I BaKuHHa, npeAJIO)KeHHaH B. FIaHKOBbIM (1951).
j1;aHHble 0 nOJIO)KHTeJIbHbIX pe3yJlbTaTaX HCnbITaHHH 3TOli BaKUHHbI
(B. K. HOBHKOB, 1952, C. SI. Jlto6amenxo, 1954) BnoCJIe4CTBHH He noA-
TBepAHJIHCb. HOBHKOB (1953), H. (1). TIOJIbnaHOB (1956) coo61uHJIH,
9TO B YCJIOBH51X 3BepO00BXO3OB BaKLI,HHa ITaHKOBa OKa3ajlaCb
He3(c4eKTHBHOIi.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BaKUHHaIjHA HOOK
BaKuniIaIZHR HOpOK npOTHB LIyMbI BBeJjeHa B npaKTHKy B 1940 r.,
LLepe3 8 JIeT nOCJIe TOI'O, KaK Moy (1932) BHCpBble yCTaHOBFJI L(yMy
HJIOTOSIJ.[HbIX Y HOpOK.
,JJTH HMMyHH3a1jHI1 HOOK npOTHB nyMbl npe,ITJIo)KeHO MHOFO BaK-
UHH, r.TIaBHb1M o6pa3OM y6HTbIX. OHH npLIBHBaIOTCA He McHee 2 pa3
C nepepb1BaMH. 1"1MMyHHTCT HenpOJjOJDKHTeJIeH. Y )KHBOTHbIX, Haxo-
JjA]IjHXCB B HHKy6aUHOHHOM nepHoAe, TBKHe BBKUHHbI, He3aBHCHMO
OT J103bI, fie npe,-pblBaiOT nH(IJeKL[HOHHbIA npon,ecc. HopKH, BaKLTHHH-
pOBaHHb1e y6HTOII BaKLTHHON, B CJIyLIae BCnbILLIKH LIyMbI AJIA noA-
Jjep}KafIHA HMMyHHTeTa o6bILIHO BHOBb npHBHBaIOTCSI HeCKOJIbKO pa3..
1_1aHKepTOH (1940, 1941) Ha 4 TbIC. HOOK ycneLHHO npHMeHH.TI
()OpMOJIBaKIjHHy, npHI'oTOBJIeHHyIO HO J1eI34JI0y-JeHKHHy H3 Jieroq-
HOF] TKaHH, TKaHH TpaxeH H MOneBoro ny3bipH, BaKUHHa UOAKO?KHO
BBOJ(LITCA 2--3 pa3a c npoMe)KyTKaMH B 5 AHeff, B A03aX OT 2 Ao,
4 MJI.
AJIJIeH peKOMeHJ oBaJI q)OpMOJIBaKIJHHy, npHrOTOBJIAeMyio no J1e-
6aiin H3 CeJIe3eHKH, npHLIeM CBO6OAHbII3 (popMaJIHH HefiTpajiH3yeTCA
HenocpejjCTBeHHO nepe)i ynoTpe6J]eHIIeM npenapaTa Ao6aBJIeHHeM
0,4 MJ1 aMMHaKa Ha KaiKJjbie 10 MJI BaKITHHbI. KypC HMMYHH3aUHH co-
CTOHT H3 2-3 HO,T KO}KHbIX HH-beKUHii 2 MJI BaKUHHbI 9epe3 KB)f( ble
7-10 aHefl.
KHHPCKOT npeAJlo}KnJ1 BaKLUHHy H3 BHyTpeHHHX opraHOB )KHBOT-
HbIX, naBLHHX OT LIyMbI, HCnbITaHHyiO HM C XOpOIIIHMH pe3yJIbTaTaMH
Ha MHOrHX Tb]CALIaX HOpoK.
0 XOpOIJHX pe3yJlbTaTaX npHMeHeHHA Ha 1800 HopKax ())OpMOJIH-
HH3HpOBaHHO13 TKaHeBOI3 BaKUHHbI 00061Ij1J1H TaK}Ke OTTO H MaK
,UepHHr H apyrHe aBTOpbI.
YcneLHHO npOBeji OHbITbI BaKUHHaL nH HOOK MoM6epr-I4opreHcOH
(1949).
XOpbKOBa5 BaKIjHHa 17pnlia fie fOJIytIHJIa HpnMeHeHnH npOTHB
LIYMbI fJ]OTOAAHbIX y HOpOK: HOipKH, npHBHTbie 3TOFL BaKUHHOI3, o6bILI-
HO 3a6oJIeBaIOT npHBHBH01{ LIyMOI3,
BaKUHHa FPOTHB LIyMbi HOpOK, rlpeLTJIo)KeHHa1 XeMMeHoM (1949),
HpHrOTOBJIfleTCA H3 3nHTeJTnaJIbHOIi TKaHII, BBKUHHa COJjep}KHT, KaK
3TBCp}K,aaeT aBTOp, BbICOKyIO KOHIjeHTpaITHfO )RHBOrO BHpyca, oCTIa6-
JIeHHOro KaKHM-TO XHMHLIeCKHM BenjeCTBOM. BaKLTHH3 peaKTnBHa:
BaKUHHHPOBaHHbie 3BCpH He 51BJI5TIOTCA BHpyCOHOCIfTeJIAMIT. fnp0-
KOe npnMeHeHHe 3a py6ex{oM (CUTA, 7jaHM9, 1-OJIJTaHAnn) B HaCTOA-
HTee BpeMA HMeeT cyxan 3M6pHOH-BaKunHa (Ka6acco H Apyrne, 1953).
Ee CPOK !OAHOCTH 9-12 Mec., A03a 0,5 MJT B3pOCJIbIM H 0 025 Ni.?I
IIjeHKaM HOpOK. BaKLIHHa BBOJTHTCH HOAKO)KHO B 3anJIegHyIO o6.TIaCTb.
McHKH peBaKL[HHHPYIOTCA Iepe3 3-4 HejejiH, 1'1MMyHHTe-r HaCTy-
TiaeT LIepe3 10 juieu. BaKITHHHpOBaHHbie HOPKH Ha 10-20 gHeFI CTpo-
r0 H3oJIHpy10TCB BO 1436e}KaHHe KOHTaKTa C BHpyJIeHTHbIM BHpyCOM.
BaKIwHHa npHMeHAeTCA KaK npo(j)HJIaKTHLIecKoe H JIe'Ie6HOe cpe)iCTBO;
OHa He3(p(peKTHBHa, ec iH 3a6oJIeBaHHe y}Ke paCnpoCTpaHHJIOCb Ha
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
()epMe. B CCCP ycnembI 6bIJIH OnbITbI E. C. 4epKaCCKOrO (1953,.
1954) no npHBHBKe HOPKaM aHaJIOrHqHOIi nOJIHBaJIeHTHOI3 rHApO-
OKHCbaJIK)MHHHeBOfi 3M6pHOH-BaKUHHbI B JZ03e 1 Mu I - nOJ[KO}KHO
HJIH BHyTpIIMbIHIeqHo.
B CCCP 6bIJIa cJ(e.laHa nOnblTKa npHMeHSITb BaKUHHy no r1yHTO-
HH JIJIH 6Opb6bl C 9yMOI3 nJIOT0 HbIX cpeAH eHOTOBHJIHbIX co6aK.
B. J1. rleTpOB npHroTOBHJI (peHOJ1H3HpOBaHHyIO BaKLHHY H3 M03ra
6oJibHOro LIyMOi3 yccypHlicxoro eHOTa. H. MHpOJIio6OB (1932)
n,pHBHJI 3TOI3 Batcumo 3 10 eHOTOBHJIHbIX cO6aK. Pe3yuibTaTbl 6bIJIH
OTpHuaTeJlbHble: peaKUHH Ha BBeAeHHe BaKUHHbI OTCyTCTBOBaJIa:
BaKUHHHPOBaHHble 3BepH npH KOHTaKTe c 60JIbHbIMH qyMOl3 3a6OJie-
BaJIH H Ha 18-23 aeHb norn6aJIH OT iIyMbl. He ,IjaBHIHI3 OnpeaeJien-
HbIX pe3yJlbTaTOB OnbIT BaKUHHaUHH no rlyHTOHH yCCypHIiCKHX eHOTOB
npOBeJIH TaK)Ke OBTIHHHHKOB H n03}Ke JI. A. JIoceB, H. C. TpoxopbeB
H )J. T. LIepHHKOB (1930).
)KHBa1 BaKUHHa rpHHa y eHOTOBHJIHbIX CO6aK He npHMeHSIeTCH,.
TaK KaK Bbl3bIBaeT Y HHX npHBHBHyIO 'qyMy.
BnepBble IIOnbITKY BaKUHHaUHH co60Jiei3 npOTHB qYMbI HJIOTOSIJI-
HbIX cueulauia C. E. COPHHa (1953), nOJIyuHBHIaH 3(4eKTHBHhie
pe3yJlbTaTbl npH nPHMeHeHHH 3KHBOI1 nOJIHBaJIeHTHOI3 aucop6aT-
9M6pHOH-BaKUHHbI, H3rOTOBJIeHHOii no McTO)IY 4epKaCCKOTO. 21 co6o-
.110 6bIJIa BBeaeHa BaKUHHa (no I MJI) H rHnepHMMyHHaH npOTHBO-
9yMHa5i CbIBOPOTKa (no 2-2,5 MJI), a 49 co6oJl5iM - OAHa BaKUHHa_
Co60JIH JierKO nepeHecJiH BaxwHHaun}o, OKOJIbUOBaITbI H BbinyII eHbl
B OAHOM H3 paiOHOB CH6HpH, He6JlaronoJly4HOM no tiyMe nJIOTOHJI-
HbIX. flocJIeuytoLUHe Ha6JIioaeHH5i nOKa3auIH OTCyTCTBHe na,ne}Ka cpe-
AH fPHBHTbIX co60JieI3.
BaKUHHaUHSI 1[pyrMx IIJ1OTO5l/ HbIX
B JIHTepaType HeT aaHHbIX O npOTHBOgyMHOI-I BaKuHHauHH ApyrHx
nJIOTOHAHhIX, KpOMe nepegIHCJIeHHbIX. HMeIOTCH JIHLUb He6OJIbuIIHe
3KCnepHMeHTbI no BaKLHHaUHH BOJIYaT (LlepKaCCKHIi, 1950, 1951).
rHeH H 6apCyKOB (IlaHKOB, 1950).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CUEL[H4)H9ECKAA CEPOTEPAIIHR H
CEPOIIPO4HJIAKTHKA I[YMbI IIJIOTOSIAHb1X
AHTH6aKTepH Hble reTeporCHHble H roMOJ10rHtHble CbIBOpOTKH
Bonpoc 0 noJIy9eHHH HMMyHHbIX CbIBOp0TOK HPOTHB 9yMbI rJIOTO-
`UHbIX aaBHO 3aHHMaJI y4eHbIX. COOTBeTCrBeHHO yp0BH10 HayKH
B o6JIaCTH 3THOJIOI'HH 9yMbI HJIOTO5TJIHbIX BHCpBble npe iaraBLHneCH
B Ha9aJie TeKyw,ero CTOJIeTH51 CbIBOpOTKH FOTOBHJIHCb nyTeM rnnepHM-
MyHH3aUHH pa3JIHLIHbIX }KHBOTHbIX, rJiaBHbIM 06pa3OM Jiowla.ueA,
KyJlbTypaMH MHKpo60B, Bbl,aeJleHHbIMH OT co6aK, 60JIbHbIX 4yMOH.
CTKpbITHe BH;pyca 4yMbI CO6aK Kappe (1905) BOJIHOCTbIO He
npHOCTaHOBIIJ10 H3FOTOBJIeHH5i aHTH6aKTepHk1Hb1X CbIBOpOTOK. OHO,
XOT51 H B McHblueM MaCnuTa6e, npoJ o.TI KaeTCn H aO HacTOOLuerO Bpe-
McHH JIJiH Hp0()HJIaKTHKH H JIegeHHH OCJION{HHI0LL1,HX LIyMy BTOpHqHbIX
HH(IeKU.HH.
BnepBble MOHOBaJIeHTHyJO, rlpOTHB 6HHOJIHpHbIX 6aKTepHii, a 3a-
TeM nOJIHBaJICHTHYIO aHTH6aKTepnHHy!O CbIBOpOTKY npOTHB 9yMbI
nJIOT051)IHbIX npezJIO)KHJIH JlnHbep (1903), l)H3aJIHKC (M3) IIHop-
KOBCKHH (1903). B o6;paLLieHHH 6blJln TIK)Ke aHTH6aKTepuuHble
JIOLna 1HHbie CbIBOpOTKH: )~kOCCOHBHJIH H FHCOHa H3 6aKTepHH, noxo-
)KHX Ha CTpenTOKOKKn, FaHCa, UeIhMaHa, baTeMaHa, MOHCKTOHa H
Konemana 113 6aKTepHH, HOXON(HX Ha HHeBIVIOMHKPOKOKKH (PpHJIJIeH-
,iepa H ap. B 6oJIbLnHHCTBe cJiyqaeB 014H JIfBa.IH He0HPCJLCJICHHble
pe3yJlbTaTbl HJIH BOBCe 6blJlH He3c1x1)eKTHBHbIMH.
fieppn (1912) npeuJ1O)KMJ1 ChIBOp0TKy OT co6aK, a ToppeA
(1913) - OT .nolnaJ[er, rHnepHMMyH1I3HpOBaHHbtx Bact. hronchosepti-
CUS. CbIBOpOTKn -9TH jeUCTBOBaJIH c IleonpeaeJieHHbIM pe3VJIbTaTOM.
11O.IIHBaJieIITHa5 HpOTIIB0qyMHaA CbIBOpOTKa no MauuyKn (1925)
rOTOBnJIaCb rHnepHMMyHH3aL[Hec Bact. bronchosepticus, cTalJH.IIOKOK-
KaMH H CTpenTOKOKKaMn It B JI03e 10--20 MJI noj(KON{HO uaaa.na
BHOJIHe y1(OBJIeTBOpnTe.llbHhIe pe3yJlbTaTbl.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
PaM03oT-rH (1925) npHrOTOBHJI CbIBOPOTKy npOTHB qyMbI CO6aK
nyTeM rHHepHMMyHH3aIUHH Jiouiaaei3 Bact. coil comm., Bact.
septicaemia haem., CTa(~HJIOKOKKaMH H CTpeIITGKOKKaMH. CbIBOpOTKa
BBOJjHJIaCb rIO1jKO}KHO. B o6meM, pe3yJIbTaTbI 6bIJIH HeonpeaeJleHHble.
H. ,apeM51UKHI3 H H. Pa3yMOBCKHII (1931) B Me}K3nH3o0THgeCKHIl
nepHo,g ycnem o BBOaHJIH ujeHKaM, 6oJIbHbIM T-IyMOIi, CbIBOpOTKy OT
Jlou.Ia.H, HMMyHH3HpOBaHHOI3 }KHBbIMH KyJIbTypaMH MHKPo60B, rJIaB-
HbIM O6pa3OM CTPenTOKOKKOB H CTa(nHJIOKOKKOB, Bb1JjeJIeHHbIMH OT
co6aK, naBHIHX OT TIyMbI. IlpeJjJIO}KeHHble n03,aHee H HMeIOIIjHe npH-
McHeHHe B HaCTOSlnjee BpeMH pa3JIu Hbie rHnepHMMyHHble JIOIUaaH-
Hble CbIBOPOTKH npOTHB 6aKTeipHI-I - CnYTHHKOB TIyMbI y co6aK -
CTpenTOKOKKOB, JjHrJIOKOKKOB CTa()HJIOKOKKOB, Bact. bronchosepti-
CUS H AP.- npH OCJIO}KHeHHbIX i- opMax TIyMbI aalOT B o6HjeM yaOB-
JIeTBOPHTeJIbHbII3 pe3yJlbTaT, HO yCTyHaIOT KOM6HHHpOBaHHbIM BH-
pyCHO-6aKTepHIiHbIM CbIBOpOTKaM. 1'13 HHX 6oJiee 3cNJeKTIHBHbI, KaK
nOKa3aJIH HaLUH OnbITbI, CbIBOpOTKH, npHrOTOBJIeHHble nyTeM KOM-
HJIeKCHOI3 rHnepHMMyHH3auHH He JIOiHaaex, a co6aK.
FoMOJIorHqHaii co5aqb5l nPOTHBOT-IyMHaH CbIBOPOTKa HMeeT P51a
HpeHMyWeCTB nepea reTeporeHHbIMH CbIBOpOTKaMH: B HeI-I HeT T4y}Ke-
poaHbIX 6eJIKOB H HeH36e}KHO co1ep}KamHXC51 B reTeporeHHOI3 CbIBO-
poTKe npeuHnHTHHOB, arTJIIOTHFI-IHOB, reMOJIH3HHOB II J[pyrHX
allTHTeJI npOTHB 6eJIKOB, KOTOPble B H3BeCTHOI3 Mepe nPOTHBOJjeI3-
CTBy}OT (4H3HOJIorHTIeCKHM 3anWTHbIM peaKwHSIM opraHH3Ma peuH-
nHeHTa. rlpH BBejjeHHH POaCTBeHHOI3 CbIBOPOTKH OpraHH3My He npH-
XOaHTCH nepepa6aTblBaTb uyx{epOaHbII3 6eJIOK. rlpeHMynjeCTBO roMo-
JIOrHT-IHOiI CbIBOPOTKH nepea reTeporeHHOI3 3aKJIIogaeTCHI TaK}Ke
B TOM, TO OHa HCKJIK)TIaeT OnaCHOCTb aHa(IJHJIaKCHH H 3aaep}KHBaeT-
CH Ha 60Jiee )jJIHTeJIbHbII3 nepHOA B Op,raHH3Me.
roMOJIOrH9Hble H reTeporeHHbie aHTHBHpyCHbie
rHnepHMMyHHble CbIBOpOTKII
FunepuMJ yKHa. co6alib.z Cbl8OpOTKa. I-HnepHMMyHHasI co6aT-IbH
UPOTHBO4yMHaH CbIBOPOTKa npegawKeHa MHOrHMH nccJIeaOBaTe.ISiMH:
H. r. 31=lreHoM (1912), H. M. THTOBbIM (1913), A. B. geaioJlHHbIM
(1913), JIOKXapTOM H l pyrHMH (1925), Jleiia.loy H JJeHKHHbIM
(1931) Hap.
,UJIH HMMYHH3aUHH }KHBOTHbIX H nOJIyT-IeHH5I OT HHX CbIBOPOTKH
3IIreH HCHOJIb3OBaJI CTepHJIbHyIO fJIa3My KpOBH, B3HTOYI y co6aK,
60JIbHbIX 4yMOI3, npH nePBOM TeMnepaTypHOM noa'beMe. COJjep3KaHHe
B Hei3 Bnpyca npOBepHJIOCb nepenpHBHBKaMH KpOBH, B3HTOII OT 3a-
6o ieBluero HjeHKa, 3,1OPOBOMy njeHKy, OT BTOpOrO 3a6oJleBluero
TpeTbeMy H T. a. MHOrOKpaTHble HH"beKgHH BHpyCa nOKa3ajii, TITO
co6aKH CpaBHHTeJIbHO JIeFKO nepeHOCSIT rHnepnMMyFIH3auHI0_ pearH-
pysl Ha BBeJjeHHe BHpyCa JIHIIIb KpaTKOBpeMeHHbIM HOBbIHIeHHeM TeM-
nepaTypbl. rlpouccc rHIIepHMMyHH3auHH JgJIHTc5i 3-3,5 Mec. B no-
cTeneHHO yBeJIn4HBaionjHxcn Jjo3ax B o6Hjell CJIO)KHOCTII OJjHOII co6a-
Ke BBOJjHTCSI ao 50 MJI Kp0BH, coJjepxcauje1 BHpyc.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
1'HnepHMMyHHa5i CbIBOpOTKa 3 ireHa 6e3Bpeaxa, nPH BBeJjeHHH
B Ha'IaJIbHOM OCTPOM nepno.z e 6oJIe3HH 6bICTpo npHBO.HT K BbI3J(O-
pOBJIeHHK), a B He60JlbLIHX a Wax coo6HjaeT 3,10POBbIM co6aKaM
naCCHBHbIH HMMYHHTeT K TayMe. THTOB rHnepHMMyHH3HPOBaJI co6aK
KaK nepe6OJleBmIHX, TaK H He 60JIeBnIHX T-IyMOK: nePBbIX - HHTpa-
MyCKyJI5IPH0 HJIH HOJjKO}KHO }KHBbIM BHPy'COM (cMeCb KPOBH OT
HeCKOJIbKHX 60JIbHbIX LIyM0I3 co6aK), a BTOPbIX - BBeJjeHHeM BHaT-IaJIe
y6HTOro BHpyca, a 3aTeM }KHBOFO BHpyca. FHnepHMMyHHble co6aKH
ToTaJlbno 06eCKpOBJIHBaJIHCb Ha 15-18 JjeHb nocjie noc eaHeli
HH'beKUHH BHpyca. Ho THTOBY, B HailaJlbHbIX CTaAHSIX 3a6oJleBaHHH
co6aK IIyMOIi BBeJjeHHe CbIBOPOTKH B 80% o6ecneTaHBaeT H3JIegeHHe.
B 3anylljeHHbIX cjlyga ix H npH HepBHbIX SIBJIeHHHX CbIBOPOTKa
He3(4eKTHBHa.
B onbITaX A. B. CHHeBa (1914) BbI3,IOP,aBJIHBaJIO TOJIbKO 50%.
co6aK, KaK H HpH OJ(HOM CHMHTOMaTHgeCKOM JlegeHHH.
Ha 3(p(peKTHBHOCTH CbIBOPOTOTaHOPO JIeTaeHHSI LIyMbI y co6aK OCO-
6eHH0 HaCTaHB JI A. B. geRtoJIHH (1913, 1922). Ero COTpyJjHHK
(1). H. OpJIOB (1922) y}Ke B 1913 r. yCTaHOBHJI, T-ITO aKTHBHOCTb CbI-
BOPOTKH B 3Ha,4HTeJIbHOM Mepe 3aBHCHT OT HHAHBHAyaJlbHbIX KaTaeCTB
co6aKH-J(OHopa. OH B TeneHHe 6-6,5 MecnueB C nPOMe}KYTKaMH B 5
J[Heli HMMyHH3HpOBaJI co6aK: HOCTeneHHO yBeJIHTaH-
BaIOHjHMHCSI J(03aMH BHpyca OT (0,2 MJI J[o 50-60 MJI), B 06igef
CJIO}KHOCTH BBORIIJIOCb J[O 700 MJI BHPYCHoro MaTepHaiia. l-lOJlyTIeH-
Ha5l no 3TOMy McTOJty CbIBOPOTKa 6bIJIa BbICOKoaKTHBHOH.
51. E. BacHJIeg (1924) IOKa3aii, YTO BHP'yC CJla6of BH;pyJIeHT-
HOCTH npnroj eH AJI51 rHnepHMMyHH3aIHH co6aK. B Te'3enne 3 Mec.-
Ka)KJioli co6aKe 6bIJIO BBeAeHO Ao 170 MJI ocJIa6JleHHoro BHpyca a
nOJIyTIexa aKTHBHaH cblBopOTKa. BHOCJIeJICTBHH BacHJIeu nepelue.m
Ha 60JIee (1OpCHPOBaHHblfl McTOJj rHnepHMMyHH3aUHH.
[lo M. A. UyKaJloBy (1928), C6opHaH rOMOJIOrHTIHaSi CbIBOpOTKa,
o6pa6oTaHHaH XJIOpO(pOpMOM, HpH HOJjKO}KHOM HpHMeHeHHH B A03e
5 MJI 1-3 pa3a B 100% HPHBOAHT K H3JIemeHHIO, eCJIH KOM6HHH;pO-
BaTb cepOTepannlo c McJ(HKaMeHT03HbIM JIemeHHeM.
llpOH3BOJjCTBO rHHCPHMMYHHOI3 npOTHBOTlyMHO13 co6agbelf CbIBO-
pOTKH B 1928 r. OCynjeCTBJIHJIOCb CHegHaJIbHbIM OTJjeJIOM no H3yYe-
HHIO TIyMbI CO6aK npH FIOJITaBCKOM BeTepHHapHO-6aKTepHOJIorlme-
CKOM HHCTHTYTe. [To B. B. KonleBoMy (1928), B l-I Bble 10 AHeu
6oJIe3HH H3JIeLIeHHe HaCTynaeT OT OJjHOKpaTHOrO HOJ(KO}KHOrO BBeJje-
HHSI 3TOIi CbIBOPOTKH B J[03e 1 MJI Ha I Kr }KHBOFO Beca (HO He McHee
5 MJI) ; npH BBeae HHH CbIBOPOTKH Ha 10-20 JjeHb 6OJIe3HH Heo6XOJjH-
MbI HOBTOPHble HH beKLwH. '4epe3 6-8 qac., pe}Ke aepe3 5 aac. H ewe
pe}Ke T-Iepe3 12-16 qac. nocJle BBe,geHHSI CbIBOPOTKH y 6OJIbHOH
c06aKH najjaeT TeMnepaTypa, HOHBJISIeTCSI anneTHT, CJIH3HCTble npH-
XOASIT K HOPMe H HCTeileHHe yMeHbHIaeTCSI. B OHbITaX KoineBoro H3
179 6OJIbHbIX co6aK 148 rOAOB (82,7%) BbI3JjOPOBeJIH.
BJIecTHIgHIi 3cNJeKT OT npHMeHeHHSI CbIBOPOTKH JIeJuoJIHHa-Op-
JIOBa, OTMeTHJI TaK}Ke COKOJIOBCKHIi (1928), a no D. Ma3eJllo (1929),
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
no cpaBH HHIO c ApyrHMH cnoco6aMH JneueHHSI ona AaeT HaHJlytiwle
pe3yJlbTaTbl.
HeAOCTaTOgHO 344eKTHBHOfI B Jlege6HbIX ueJIHX 6blJia npHroTOB-
JIeHHaSi B 1925 r. JIOKXapTOM H apyrHMH Co6aib5 rHnepHMMyHHaH1
CbIBOpOTKa, TaK Ha3bIBaeMbIH KCepOTOKCHJIHH> (Mai3KJ1, 1927).
AHTHreHOM AJIH npHrOTOBJIeHHH CbIBOPOTKH HycX3ra (1929) caiy-
)KHJI MaTepHaJI OT a(ppHKaHCKHX XOpbKOB. CbIBOPOTKa He Hailiza
npHMeHeHHA' KaK Jletie6HbII3 npenapaT H 6OJIbme ynOTpe6JIsJIacb
c npo(PHJIaKTHtie0KOI3 ueJlblo.
,qenKHH (1931), JIeHAJIOy H AeHKIIH (1931) npOBepHJIH CbIBOpOT-
KH JIOKxapTa H HycX3ra H yCTaHOBHJIH, LITO HH OAHa H3 HHX He 34)-
(peKTHBHa. CbIBOpOTKH 3TH He3(1)()eKTHBHbI HpH HepBHbIX npoSiBJIe-
HHHX 6oWIe3HH H B COtieTaHHH C reKCaMeTHJIeHTeTpaMHHOM, BBOAHB-
HIHMCH ,LaJIJIHHI'OM aJIH Toro, tITO6bI cnoco6CTBOBaTb HX npOHHKHO-
BeHH10 tiepe3 reMaT03Hiie(pa.IH14ecxHIi 6apbep.
CbIBOPOTKa Jle&AJIoy H UeHKHHa (1931) no.lytiaeTCSI OT co6aK,
HCKYCCTBeHHO HMMYHH3HpOBaHHbIX JI160 nepe60JIeBHIHX TIyMOH, KO-
TOPbIM ABa AH5i noApsiA HOAKO}KHO BBOA51T no 20 MJI 20% CycneH3HH
tiYMHO13 CeJIe3eHKH HJIH JIHM(paTHtIeCKHX }KeJ1e3. L4epe3 7 AHe13 nociie
HccJIeAOBaHH51 no PCK co6aKH o6ecxpoBJIHBaioTCSI, noJlytieHHa5I
CbIBOpOTKa OtIHIuaeTCH H KOHueHTPHpyeTca HYTeM oca)KAeHHS1 20%
CyJIb)aT-aMMOHHeM, AHaJIH30M H BbinapHBaHHeM B BaKYYMe Ao
I/5 o6'besa. AKTHBHOCTb CbIBOpOTKH npOBepHeTCH B PCK H B peaxuHia
HeI%ITpaJIH3auHH (0,1 MJI CbIBOpOTKH )JOJI}KHa He)3TpaJIH3oBaTb
10 000 HHq)HgHpyK)IuHx AO3 BHpyca).
B 9KCnepHMeHTe CbIBOPOTKa B A03e 10-30 MJI HHTpaBeH03HO
HJIH HHTpaMyCKyJIHpHO o6pbIBaJia 3a6oJIeBaHHe y Co6aK. B eCTeCTBeH.
HbIX YCJIOBH51X CblBOpOTKa, cor.nacxo aaJxJiHHry (1931, 1934), 3(p(~eK-
THBHa B A03aX .20-50 MJI, OCO6eHHO npH BBeAeHHH B TetieHHe
HeCKOJIbKHX AHeFI nOApHA B Hatiajie 3a60JIeBaHH5I, B 6oJiee n03AHHX
c.nytlaxx oHa yJIytlIHaeT TeqeHHe 60JIe3HH, a npH HepBHOI1 KJIHHHKe
He3(1(peKTHBHa. 3TO OTMetIaloT TaK}Ke CTIOapA (1931), Pai1T (1932),
Jlbexcya H BepTpaH (1933), IIa13Ji (1933), BepJIHHAe (1937), Jle4)-
IuTaAT (1942) H ap.
Ho MoppHcy (1933), npH KOM6HHHPOBaHHOM npHMeHeHHH 3T0)i
CbIBOPOTKH C 6oJibHIHMH A03aMH HyKJieOTHAa K-96 3HagHTeJIbHO CHH-
rKaeTCSi CMepTHOCTb, yCKOpHeTCH BbI3AOpOBJIeHHe H npeJOTBpa)I;aeTCST
pa3BHTHe HepBHbIX nPORBJIeHHI3.
HCXOAS) H3 TOro, TIT'O 1O'ITH Kax(Aan B3poCJIaH co6aKa HMMYHHa
K iyMe, IIJIaHType (1935) OAHOKpaTHO BBOAHJI B3pOCJIbIM co6axaM
20 MJI 20% CycneH3HH ()OpMaJIHHH3HpOBaHHOI3 (0,1%) ce.)e3eHKH
3apa)KeHHoro tiyM013 XOPbKa H tiepe3 10-12 AHei nOABepraJ1 Hx
TOTaJIbHOMY o6eCKpOBJIHBaHHIO. aji5i 60JIbwwefj aKTHBHOCTH OH CMe-
HIHBaJI CbIBOpOTKH OT 30-50 co6aK. CbIBOPOTKa IIJIaHType aKTHBHa
B nepBbie 7 AHeI3 3a60JIeBaHHH. OHa BBOAHTCH IIOAKO)KHO C npoMe-
)KYTKOM B 2 AHH B A03e 3-6 MJI Ha I Kr Beca. CbIBOPOTKa 34(peK-
15* 227
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
THBHa H HPH HC,PBI1b1X HBJ1CHH51X, eCJIH ee HPHMCIIHTb B HaVaJ1e HX
B03liHKIIOBeiiHH H 3a 1/2-2 tiac. Jj0 9TOr0 BBeCTH ypOTpoHHII.
Fop9 ii jLpyi-He (1936) HPIiMCHHJIH B 27 CJIy'-IaHx Cb1BOpOTKy, lipH-
I'oTOBJIe1HIy10 110 IIJIallType. HO HX IIa6JIro13(mHHAM, gOCTaToLIH0 oAlI011
HH"UCKuRH 20 WTI AJ12 Bb13,i[opOBJIeH1I5l. 0,jHaKO BO H36e)KaIIHe peu11-
jj11Ba IjeJlecoo6pa3HO HOBTOpHO BBeCTH Ty 3KC 103y gepe3 8 H 15 [Hell.
CbIBOpoTKa TepaHeBTH9eCKH 9(M4)eKTHBHa H HpH oCJIO?Klleiil lx.
Fops m 171,pyl'Be (1937) , a I103JjHee JleJiauJje ( 1938) HCHOJIb3oBaJIH
J .TIII I'll HepHMMyllH3aU1114 co6aK BHpyC zIyMbI HJIOTOHJWbIX var.
putorius. D-TOT BHpyC jjBa>Kjib1 C HepepblBOM B 20 qac. BBOJjHTCH HOA-
KO3010 B Bi1f C 20 MJI CyCHCH31111 Ha (j)H3HOJIOrH'-ICCKOM paCTBOPe I : 5
113 CMCCH CCJIC3CHKH, HeoeHH, JIHM(jJaTHYCCKHX y3JIOB, JICFKIIX H M03ra
'IVMIIbIX XOpbKOB, 3a6HTbIX B arOHaJIbHbII1 HepHOA, HJIH 10% cycHeii-
31111 0,111011 CeJle3eHKH XOpbKa B Jj03e 10 u, 3 pa3a C HHTepBaJIaMH
ii IIecKOJIhKO xiefi. HOJIy4IaeMar gepe3 7 AHeR Cb1BOpOTKa THTpyeTCH
Ha x(,,pbKax HJHi B PCK, Hp1~ICM aHTHreHoM CJIy KHT ueHTpH4)yraT
20(1/a CycneH31411 ceJIe3elIKH HyMIIOro XOpbKa. TaKHe CbIBOPOTKH 9(1-
(t)eKT111111b1 H B Hpo(j)HJIaKTHlIeCKHX H B JIe9e6HbIX Heim. HC11bITaHHC
aKTIIBIIOCTH rHIIepHMMyHCblBOpOTOK B peaKILBH CB93bIBaHF5I KOMHJIe-
MCIITa npuMeHSIJIH TaKiKe HaKJi H BpoyH (1935), bpara (1943).
Talc, HO bpara, CbIBOpOTKa, He CB93bIBaBHIan KOMHJIeMeHT B pa3Be-
jjeH11H 1 : 1000-1 : 8000, KaK .neve6Hoe Cpe, CTBO He FOAHTCH.
HpIIrOTOBJICHHaH Uep6o (1938) CbIBOPOTKa HpH riomoH[H aHTH-
reHa, COJ3ep?Kaiucro BHpyc 'iyMbi, naiiojim i H Hapa(1)HH, OKa3aJIacb
M a JI O MMI13 H O1i.
HplrMCIrHI3 BCHI-CPCKYIO rOMOJIOrnoHyIO CbIBOPOTKY ,
A6omm (1939) 1I3Jie4HJi 25 113 28 60JIbHbIX iIyMocr co6aK.
Fefirep (1939) HP14FOTOBIIJI BbICOKoaKTHBHyIO FOMOJTOFHLIHyIO HPO-
THBOgyMHyIO CbIBOpOTKy. 0 xopoweM ueIiCTBIIH 9TO1'I CbIBOPOTKH
B jj03e 4 MA Ha I Kr Beca 000611,HJIH T1eI)mTaAT (1942), HHMaHJ(
(1942, 1944), Bepxc H Fops (1943), BeppHHrep (1946), FyTHpa,
MapeK, MaHHHHrep H MOTIH (1954). Ho HHMaHjjy, CbIBOPOTKa BBO-
111TCH B 103e 2-3 MJI Ha 1 Kr Beca; eCJi11 TeMHepaTypa He cHH}KaCT-
CH, TO 11111bCK13HH rnoBTOpleTCH Hepe3 24 LIaca (B Mexblleli Ao3e).
Ho Bepxcy H Fops, AJIH HpeJ oTBpam,eHHII peUHAHBa 6oJIe3HH
CJ1eAyCT 11epe3 8-15 AIiefl HOCJle Bbi3JLOpoBJIeHmi IIOBTOPHTb HH'beK-
U ilo ChIBOPOTKH B 1O3e OT 10 J3o 50 MJI. BeppHHrep pexoMeHAyeT
BBOAIITb CbIBOPOTKY B J303e 2-3 MJI, JIy'me Bcero HHTpaBeH03HO,
B CO4CTaH11H C OMH,1;IBH0M, IITpCHOM, Ka3eHHOM. B OHbITaX LHyJibua
(1948) HpH BBeJ3^HHH B CHHHIIO-MO3FOBOII KaHaJI CbIBOPOTKa Fecrepa
OKa3aJrOCb Ile9(1)(11eKTHBHOH.
X11,71 .1 11. 11 APyrHe (1942) B OHb1Tax Ha XOpbxax HOKa3aJTH, 'ITO
oAHOKpaTrIoe BBeJeH11e ChrBOpOTKH He9(1)(JeKTHBIIO, OAHaKO ecJIH
Cbli;opoTKa BBOJIITCSI B Hawml,11011 CTaAHH, TO 6oj1e3Hb He HporpeC-
(MK IIaCTyulac,r aKTnBllblll HMMyIIHTeT, KBK HOC.IIC C14MyJIb-
CHpVC1' V COI
TaHH011 11pHBHBK11.
B. (1). AAomaimnc (1950) B P3HHIIX CTa,13H51X '-IyMbi peKOMeHayeT
6OJlbmHe A03bl - AO 150 MJI CbIBOpOTKH, 9T0, HO HaWHM JjaHHbIM, He
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BbI3bIBaeTCH HeO6XOAHMOCTbIO, a HHorAa H npoTHBOnOKa3aH0 Bb13bI-
BaH nepeB036y}KReHHe, TOPMO)K HHe aKTHBH0i3 jjeHTeJIbHOCTH opra.
HH3Ma. IIo3AHee A,ijOMaHHC (1954) peKOMeHAOBaJI CbIBOpOTKy H
,i[03bI, npeAJIO}KeHHbie HaMH.
F. A. CHHpoB (1952) rHnepHMMyI-IH3HpoBaJI co6aK rIOCTeneHHO
Bo3PaCTa1OH1HMH j103aMn Bnpyca (3a 7 HH'beKUHH BBe, eHO OT 440
Ao 590 MJI Ae(j)46pHHHpoBaHHOH KPOBH H OT 20 Ao 40 r napenxHMa-
TO311bIX 0PraHOB T-IyMHbIX cO6aK). flojly'-IeHHan CbIBOpOTKa B 103e
20 MJI npeTioxpaHHJia OT 3a60J1eBaHHH HjCIIKOB, 3apa}Ke11HbIx 6OJlb-
IHOIi AO30II (5 MJI) Bnpyca.
KoneB, 3HreH, MHXaAJIOB (1937), liaHKOB (1951) CSI-ITaJIH, wITO
HPOAYL&CI1TaMH rnnepHMMyHHOf4 CbIBOpOTKH MOryT CJIy}KHTb TOJIbKO
riot
OAIICTble C06aKH, HOTOMY 1ITO TaK Ha3bIBaeMblx
P
HO'ITH HOB03M0}KHO 3apa3HTb gyMOI3.
KaK nOKa3bIBaIOT Ham AaHHble (I-1epKaCCK14fI, 1950, 1951, 1954),
FHH0PHMMYHH3aUHH BHOJIHe Bo3MO}KHa, TaK KaK 3Ha-
'IHTeJIbIIO nOBbIIIIaeT THTp coAepx{aujixcH y IllX B KpoBn npoTnBO-
LIyMHbIX IIMMyHIITeJI. MbI ycnenlHO mHnepHMMYHf13I4POBaJIII paHee
nepe6oJlesnlnx rIPOCTbIX co6aK, co6aK-peKOHBaJIeCIjeIIT0B, co6aK,
BbI}KHBIIIHX noc ie OCTPbIX OnbITOB, BaKUHHHpOBaHHbIX co6aK, Bb16pa-
KOBaHHbIX co6aK HO CTapOCTI4 H ApyrHM npHTIHHaM, Hamm ;iaHHbie
0 HaJIH 1HH B CbIBOPOTKaX KpOBH 3AOp0BbIX co6aK allTHTeii, HeHTpa-
JIH3yIOIUHX BHPYC TIYMbI rIJIOTOHAHbIX, H HOBbIHIeHHH HX THTpa npi
rHnepHMMyHH3auHH fOJIyT4HJIH nwwiHoe nOATBep}KAeHHe B HccJieAOBa-
HHHX OTTO H AP. (1955). FHnepHMMyHH3anHH co6aK ocyweCTBJIH-
JIaCb HO pa3JIHYHbIM cxeMaM. Flo OaH0i1 H3 exeM, npHMeHHBIIleI'ICH
HaMl4 B 1948-1949 rr., rHnepHMMyHH314pyeMbIM IKHBOTHbIM CHaHa-
JIa 2-3 pa3a BBOAHJIaCb HHaKT14BHPOBaHHaH BaKUHHa MJIH OAHH ipa3
}KHBa5 raKuHHa, a 3aTeM npOH3BOAHJIOCb OT 5 Ao 7 HH'beKUHH pa3-
JI14gHbIX IIITaMMOB CBe}Kero aKTHBHOI'O BHpyca, B nOCTeneHHO B03pa-
CTai0Iij14X a03aX, Bbi3bIBaiOI4HX LIyMy Y KOHTPOJIbHbIX CO6aK Ha
5-7 JReHb.
C 1950 r. MbI nepenijll4 Ha yCKOpeHHbllt McTOA rHnepnMMyHH3a-
uHH. B3pOCJIble co6aKH, B npoIHJIOM nepe6oJIeBHIHe qyMoi'I HJIH BaK-
UHHHPOBaHHb1e [POTHB LIyMbI, TpH}KAbI, c nepepbIBOM B 4 Aim, rHIIe-
pHMMylIII>HpOBaJIHCb B03paCTaiOIijIIMH A03aMH cMecbio HMMyHOJIO-
rHHeCKn pa3JIIIHHbIX IHTaMMOB BHpyca; TOTaJIbHO 6pailaCb KPOBb
Yepe3 5 AHei'i noCJie nOCJiejHeli HH'beKRIM. ECJiH npoHcxo, eHHe
co6amj 6hIJ1O Iien3BeCTHO, TO nepBan HH'beK4MI HpOH3BOJUIJIaCb
TPOHHOH A0301i }KHBOII fOJInBaJIeIITHOII 3M6pIloH-BaKUHHbI, a BTOpaH
H TPCTb9 IHHepHMMyHH3aIjHH c nepepblBOM B 10 AHec - BHpyJieHT-
HbIM BI,pvCOM. 4TO6bI CbIBOPOTKa 6bIJIa II,po3pa4HO1i, KPOBb Y 101I0-
POB (T('T,l,'IbllO n3 art. carotis) 6paJlaCb HaTOIIjaK Will HC PaHbnle
3---1 tII'C IIOCJie KopMJIeHHH. OTCTOHBHIaHCH CbIBOPOTKa OTcaCbIBa-
Jiach I?( IRepr,HpoBaJlacb 0,5% cj)elIWIoN H nponepnJiaeb Ha CTepHJib-
HOCTbb Ii 6e3Bpe,ijiIOCTb. Jle,le6HaH 3(j)(j)eKTHBHOCTb CbIBOPOTK1, ee
npc emit, iioie H HelTpa.In3yioILwe cBOIICTBa H3yr7gajlilcb Ha co6alax,
JiHCnuax, co6ojiix, BOJIKaX, a TaK}Ke Ha PKD. UJZH HCIIbITaHHH lieIi-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TpaJIH3yIOIIJe1t CII0006HOCTH CbIBOPOTKH H;pHMeHHJIH XOpOIHO H3BeCT-
Hble HITaMMbI BHpyca, a B KOHTPOJIb BBOJZHJIH ewe CbIBOPOTKy
1-1,5-Mec i4HOro 3,L OpOBOro co6a4bero Lue?HKa. ECJin OJLHa H Ta )Ke
CbIBOpOTKa HefiTpaJIH30BaJia pa3Hble TI3HbI BHpyca, opHeHTHpOBKOII
CJiy}KHJia pa3HHua THTpOB. B Ta6JI. 18 npHBeJj0HbI gaHHble XapaK-
TepH3ytoLuHe aKTHBHOCTb O,L HOI3 H3 cepnll fOJIy4eHHOII HaMH B
1949 r. FHHePHMMYHHOM CbIBOpOTKH. Onbi'rbi npOH3BeJ(eHbI Ha 150
OnbITHbIX H 30 KOHTPOJIbHbIX PK3, 15 OHbITHbIX H 6 KOHTPOJIbHbIX
LUeHKaX.
Ta6JIHI a 18
AKTHBHOCTb H HeINTpaJIIk3y!ou a9 CH0006HOCTb rOMOJIOIH'IH011
rHHepHMMyHHOl CbIBOpOTKH HPOTHB 9IyMbI HJIOTOSIJjHbIX
00
Pe3yJIbTaTbl
3apaBCeHHH
HHOKyJiiuHA pa3BHBalo-
MHMCH KypHH. 3M6pHOHOM
U r'
5 ~
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0,1 MR +
0,1 IM cbi-
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na IueuKax
(3M6pH0-
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10/1
+ Ba 11 AeHb
2
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6 MR
-
2
-
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-
+ Ha 7 J[eHI,
5
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+ Ha 16 Jlexb
2
KOHTp.
5 MR
-
2
-
--
-
+ Ha 8 JIeHb
5
15 MR
5 Im
5
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20/17
20/1 (1 : 3)
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5 of
-
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-{- Ha 7 J[eHb
Y C JI 0 B H bi e 0 6 0 3 H a q e H H R: YHCJIHTeJIb-KOJIHReCTBO 3apa)KeHHhIX PK3;
31faMeHaTe.lb-KOJIHgeCTBO P1KHTeiieli HepBHO-pel[enTOpHbix HpH6opOB HepBHOH
CHCTeMbI, KOTOPble pe(jJIeKTOpIIbIM nyTeM IIOBbIInaIOT pe3HCTeHT-
HOCTb OpraHH3Ma H CHOCO6CTByIOT ero Bb13JjOpOBJIeHH1o. YcneHIHOe
-penleHHe 3aAa'H ynpaBJIeHHH LIyBCTBHTeJIbIlOCTbiO KJIeTOK, BOCnpH-
HMLIHBbIX K BHpyCy, no MHeHH1o A. T. KpaBLleHKO (1951), P03KO
HOBbICHT 3(X(peKTHBHOCTb cneuivj HLIeCKOIi CepOTepanhH.
J1e'e6Han 3()(IJeKTHBHOCTb npe,IZJIO}KeHHOIi HaMH rHnepHMMyH-
HOIi CbIBOPOTKH 6bIJIa yCTaHOBJIeHa B pHae JIa6opaTOPHbIX 3KCHePH-
McHTOB H npH ec npHMeHeHHH B HIHpOKOFI BeTepHHaPHOR npaKTHKe.
TaK HanpHMep, 3 IueHKaM B 1, 2 n 3 JjeHb 3a6oJIeBaHH5I LiyMoii H
3 iueHKaM Ha 6, 7 n 8 JieHb TpeXKpaTHO BBeJ[eHa CBIBOPOTKa B J 03e
0,5 MJI Ha I Kr Beca. H3 HHX 5 LueHKOB Bb13J OPOBeJIH H OJ[HH, Bnep-
BbIC HOJIVLIHBHIrr6 CbIBOPOTKY Ha 8 JjeHb, - natl.
H3 58 JjOKyMerrTaJIbHO y'TeHHbIX co6aK Pa3HbIX nOpoJ( HoJ1BCp-
raBIIIHXCH B 1949 r. neLICHHio Hanlef CbIBOpOTKOII, 44 (CBbiLHe 80%)
H3JIe'HJ rJCb H 9 (20%) rraJIH, a 113 53 Co6aK, 6oJlbHbrx HyMOii, He
HOJlyLiH131UHX CbrBOpoTKn, 37 (69%) na.nn H 16 (31 %) H3.ne'erlbl.
1151 IIJrJHOCTpar(nrr na piac. 43 nprrre;ieii c,,iytiaii JIC:Ie6noro
11pHMeiiCHH5i CbicOp)OTKIr V' CnaiIHCJISI Chllp('ii> , KOTOPOMy Ha 7-oil
Jjellb 6o,3c311H npai TcMrnepaTypc 40,6? Bncrielro 10 MJI Cb1BOPOTKII
Hanrero 11p11IOT013JIeHIM. LIcpe3 8 'IaCOB --- pe3KOe CIIH?KCHHC TeMne-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
O
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HaH KpHBa1 co6aKH FHpef?.
paTypbl (Ha 2,1?). Ha c.neJyIolZHI3 1(eHb noxBJIeHHe anneTHTa, TeM-
nepaTypa 38,5?, pe3Koe yMenbITIeHHe BbLAeJIeHHii H3 rria3 H Hoca.
LIepe3 aeHb nocjle BTOPOFO BBeJZeHHH CbIBOPOTKH - HOpMaJIbHaH
TeMl7epaTypa, XOpOHIHH anneTHT, nOJIHoe BbI3,ROPOBJIeHHe.
23 24 25 26 27 28 1 2 3 4 5 6 7 3
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9 10 11 17 13
Pic. 44. Pe3yJ1ITaTbt JIC lCHNH I rlnepuMMMYItr1OF1 CbIBnpOTKON. TeMnc-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
'MapTa, T. e. Ha 14, 15 H 16 AeHb 6OJIe3HH, BHYTPHMbIIIIeLIHO BBeAeHO
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BpaLla MOCKOBCKOrO 06lueCTBa OXOTHHKOB B. H. TIIO6CKOro, npH
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Ba B. A. 14BaHOBa, H3 16 co6aK BbI3,aOPOBe.Tio 12, T. e. 75%; BeT-
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'CeJIe3HeBa - H3 37 CO6aK BbI3,aOPOBeJIa 31, HJIH nOIITH 84%,
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paobHOIi IUKOJIe CO6aKOBOgCTBa H3 CBbIIIIe 140 Jle'ieHHbIX CO6aK
BbI3,aOPOBeJIO nOLI'rH 82% (F. C. FpHHIHH). B OAHOM nHTOMHHKe
H3 15 TH}KeJio 60JIbHbIX LIyMOFi CO6aK, JIeLIHBIUHXCH Hameii CbIBO-
pOTKOIi, Bb13AOPOBeJIO 11, B ApyFOM nHTOMHIIKe H3 3-3, B TPeTbeM
nHTOMHHKe H3 98-95 H T. A. H TOJIbKU B OAHOM HHTOMHHKe
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pHHapHOIi HOJIHKJIHHHKH McJIKIIX }KHBOTHbIX A. BypMHCTpOBa, IAe
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KOB co6aK, OHa .
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LIeCKOe JIegeHHe H BBegeHHe neHHuHJIJIHHa. BJlage.leu AaJI B MOCKBy
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TeJierpaMMy H rHOJIYEIHJI Haiuy rHnepHMMyHCbIBOpOTKy. IIpHBeAeM
BbIfHCKY H3 ero IHCbMa Ha HMH HayTIHoro pyKOBOAHTeJISH nJIeMeH-
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}KeHHaH HaMH rHnepHMMyHHaSi co6aqbH CbIBOPOTKa B nepsbie AHH
6OJIe3HH OKa3bIBaeT BbICOKOe TepaneBTHgecxoe AeHCTBHe. Ee OAHO-
KpaTHOe BBeAeHHe, KaK npaBHJIO, o6JIergaeT Te'-IeHHe 6oJIe3HH H He-
peAKO npHBOAHT K BbI3AOpOBJIeHHIO. BaTeMaH (1937) H apyrxe aBTO-
pbI CLIHTaIOT, XITO IHnePHMMYHHaSI CbIBOPOTKa 3(j4eKTHBHa TOJIbKO
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npHMeHeHHIO CbIBOPOTKH (LlepKacCKHI3, 1950), OAO6peHHOMy McTO-
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JIeHHeM BeTepHHapHH MHHHCTePCTBa ceJIbCKOI'O XO35IIiCTBa CCCP,
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,qeHHSI.
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HY}KHO yqHTbIBaTb HHAHBHAyaJIbHbie oco6eHHOCTH Ka}KAOx 60JIbHOH
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A03y.
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6eHHOCTHMH peijHnHeHTa H HMMyHOJIOrHLIeCKHM OTJIHTIHeM BHpyca,
BbI3BaBIIIerO 3a60JIeBaHHe, OT BHpyCOB, ygaCTBOBaBHIHX B rHnepHM-
MYHH3aIjHH AOHOpOB.
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THqecKoe JIegeHHe (cepAeqHbie CpeACTBa H Ap.), a npH nOHBJIeHHH
OCJIO}KHeHHI3 BBeAeHHe aHTH6HOTHKOB H cyJIb(paHHJIaMHAOB. Em e
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HCT CMbICJIa Ha3HaLIaTb cepoTepanHlo no HCTe'-ieHnn 15 n 6ojlbnIe
,KHeii OT IlaLiajla 6oJie3HH. KK 3TOMy nepnoAy HMMyHHTeT HPOTHB
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Bpaga CBOJjHTCH K fOJIaB.neHHIO BTOpHLIHOi1 HH(j)eKuHn> . BhIBOJj 3TOT
3KCnepHmeHTaJIbHO He 060CHOBaH, npOTHBOpegnT MHOFOgHCJIeIIHbIM
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Ca LlyMbl OT co6aK, 6oJIbllblx H HaBHIHX Hepe3 6oJICe npOJjOJIA(HTCJl)-
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pHn 60JIe3HH, KapTOLIKH yLleTa, CHPaBKH it T. Bh13,jOPOBeAO 1039
co6aK, HJIH 82,7%. HepeAKO H3JIegeHHe HaCTynaJlo IIOCJIe 1-2
nH-beKuHH CbIBOpOTKH. B C135][311 C 3THM ChIBOPOTKa peiueHHeM COBCTa
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BaeT 3HagHTeJIbiIoe yxyAiueHne H pe3Koe yCKOpeHne naTOJIOrH4eCKOrO
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HepBHOH cncTeMe: o6oCTPHIOTCH BOCnaJIHTeJIbHble npoueccbl, pe3KO
yBeJiHLIHBaeTCfi BcacblBaHHe BocnaJIHTeJlbnblx npOJjyKTOB, B PC3VJIb-
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JjaN(e 0006LUHJI, LIT0 78% co6aK, JIeLIHBWHXCII Ha AHaIjblpe CbIBOpOT-
KOII, norn6Jio, a H3 JICLIHBHIHXCR CHMnTOMaTH11eCKn fOTH6JIO B OJ1110M
c,nyLlae 43%, a B JjpyFOc - TOJIbKO 11,60/0.
KaHTCpoBuL1 (1947) Tar Ke mnoro pa3 Ha61Ioaao cyJjoporn
B TegeHHc 24 LIae. noCJle HHrbexuHH CbIBOpOTKOH, a B OCO6eHIIOCTn
aHrJInHCKOH. ABTOp nojlaraeT, no BBeaeHHe CbIBOpOTKM HapynIaeT
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B OJjllom CJIyLiae HPHMeHeHnx rHnepnMMyHHOM co6aubeil CbIBOpOT-
KH - IICCKOJIbKO TbIC5IH CJIyLIaeB - OHIM111iioi OTpnuaTeJlhJION (I)a3bl
110 01,110, XOTSI V 60.nhHblX >KOI3OTHbIX IICpCijKO 6bIJiH o6111npIIble 110-
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rJP(1}K;ja:`I' II0Pi;IIb1e OG'I;iihl[~IIIISI. I11)11 IbIJIIIfull IICpBHbIX Hi3TIQ1111H
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cepoTepanHx MOxceT oc.naOHTb TetieHHe 6oJIe3HH H HHorJja Jjaxce no-
BeCTH K BbI3JjOpOBJIeHHto.
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(()eKTHBHa y njeHKOB MJiaJ[IHero BO3paCTa, B 3anymeHHbIX CJ1yqa5Tx
H npH nOpaxceHHH HepBHOFI CHCT'eMbI.
B OHbITaX B. B. KOHre (1913) CbIBOpOTKa 3Ta 6bIJIa npHMeHeHa
y 4 C06aK H BOJIKa. F1aJIH 1 co6aKa H BOJIK.
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3(f (4eKTHBHa H Jjaxce npHqHHHeT Bpe)j, TaK KaK coJjep KHT npegHnH-
THHbI, nPOTeOJIHTHTIeCKHe 3H3HMbI H pyre allTHTeiia, BO3HHKa1OIIjHe
B opraHH3Me JIOHIa,L H npH ee rHnePHMMYHH3aUHH co6aTlbeli KpOBbIO.
IIO FeMMeJlbMaHy (1930) OHa HHOrJja B HaIa.1IbHOli CTaAHH 6oJle3HH
3(p(peKTHBHa. JIOIna,TWHaH CbIBOPOTKa OKa3aJlacb MaJIoaKTHBHOI3,
He JjaJia YJLOBJ1eTBOPHTeJIbHbIX pe3yJIbTaTOB B OHbITBX Fop H .lleJlaH-
.ae (1936), HMMYHH3HPOBaBI11HX Jiomajjeli 3MyJIbCHe!i H3 OpraHOB
XOpbKOB, 3apa}KeHHbIX BbICOKOBHpyJIeHTHbIM BHPYCOM H y6HTbIX
B arOHaJIbHOM nepHoL e? CbIBOpOTKa THTPOBaJIaCb Ha XOpbKaX, IijeH-
KaX CO6aK H B PCK no TOl1 }Ke McTOAHKe, TO H CbIBOPOTKa rime-
PHMMYHH3HPOBaHHbIX co6aK.
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TOHJ1;HbIX. FIocRe,aHHe nOJIytiHJIH n0 900 r BHpyca gyMbI. lIpHrOTOB-
JICHHaSi B. A. HaHKOBb1M (1953) JIoHIaJjHHax CbIBOPOTKa npOTI-IB LIyMbI
HJIOTOAJjHbIX 6bIJIa 3(1J(JJeKTHBHa TOJIbKO B nePBble T HH 6oJle3HH,
n03Jj1Iee - He3()())eKTHBHa. TaK, 113 10 60JIbHbIX Co6aK, BbIHIeJHIHX
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II Bb13AOPOBeJIH TOJIbKO 2.
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3 reH, B TelleHHe 2 H 6 Mecm ueB BBOJI,HJI K03aM HHTPaBCIIO3HO OT 1 MJI
Jjo 15 MJI, a 3aTeM nOJjKO}KHO aO 10 MJI Ha HHbeKUHIO (47,5 H
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
H 181,2 MJI Ae(JH6pHPOBaIIHOil KPOBH '-IyMHOII CO6aKH) . K03bI nepe-
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rIOJIy~IHJIH, rHnepHMMyH143HpyH CO6aK BHPYCOM H BO36yJ1;HTeJI5IMH
BTOPHqHbIX HH(jJeKuHN. BBeAeHHaHH B KOJIHqeCTBe 10 MJI Ha paHHHX
CTaAHSIX 3a60JIeBaHnH, oHa OKa3bIBaJIa 3aMeTHoe TepaneBTHLIeCKOc
JjeIICTBHe. FIpH BBC)wHHH Ha 6o,nee H03AHHx cTaAHHx 60JIC11H pe-
3yiIbTBTbI 6bIJIH McHee 6JIaronpHHTHbI, a Ha CaMbIX r103AHeHIuHX CTa-
jjIISIX Ae1iCTBHe ce 6blJIO pa3JIHYHo. CbIBOpOTKa COBepuleHHO 6e3Bpejj-
Ha, OAHOKpaTHOF1 nI,pHBHBKOI%I BepnIIITuy (1929) yAaBajioeb Aa}Ke
B TH}KeJIbIX CJIy'Iaux 06pbIBaTb gyMy y HeAaBHO 3a60JIeBHIHX co6aK.
OjjHaKO JIeflajioy H JeHKHH HPHIHJIH K BbIBOAy, T1TO 3Ta CbIBOPOTKa
He HMeeT 60JIbIHOI3 ueHHOCTH. LllyJlbue (1935) TaK}Ke He Ci1HTaeT
CbIBOpOTKy HyCXera H JilTeKepa BePHbIM CPCJ CTBOM npH 'yMe, TaK
KaK CMePTHOCTb npH ce HpFIMeIleHIIH , oxojwJia Ao 37'%?
JIHrrJlb (1934, 1935) npHrOTOBHJI rIHTHKpaTno KollljeHTpnpoBall-
Hylo npOTHBOLIyMHylo CbIBOpOTKy, arrJIIOTHHHpyloHjylo Bact.
bronchosepticus, Streptococcus cerebris canis H B 6OJIbH10Ii Ao3e-
10-20 MJI - AeIICTByIOHjyIO KaK UPOTIIB BHpyca, TaK H [I OTHB B03
6yAHTeJleli BTOPHqHbIX HH( eKHHH (J1eHTU, 1934, MoppHc, LUTOKapA
H CnaFIAeH, 1934, FlepexoH, 1934).
T. A. KoHAaKOB (1951) noJiygHJI CbIBOPOTKY OT tKepe6HT, HMMy-
HH3HpOBaHHbIX HeCKOJIbKHMH IIITaMMaMH BHpyca ilyMbl HJIOTOSIJjHbIX
var. Canis it var. vulpes m HHTbIO BIIAaMH 6aKTepuIi, BbljjcJleH-
HbIX OT nyMHbIX }KHBOTIIbIX. ABTO';p CHTaeT JIOIHaAHHyro CbIBOPOTKY
9(p(peKTHBHee co6aTIbe3i, oco6eHHO B P IHHHX cTajjHSlx 3a6oJleBannH..
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B HacToxu(ee BpeMx 3a py6excoM Bblpa6aTbIBaercH pexoMeHZjye-
MaH AJIH TepaneBTHTLeCKHX ueiiel3 CbIBOpOTKa co6aK, rHnepHMMyHH-
3HpOBaHHbIX BHPyCOM xiyMbI, COnyTCTByIOU.JHMH 6aKTepHHMH H HX
TOKCHHaMH.
CbIBOpOTKa H KPOBb co6aK-peK0HBaJlecgeHT0B
Ho (DpoMMepy (1921), KoHre (1927), BeMe.lbMaHy (1930) H Ap?,
CbIBOPOTKa H KPOBb C06aK-peKOHBaJIecueHTOB - He30eKTHBHbI.
O,i[HaKO xopouiHe pe3yJlbTaTbI noJIyqHJIH J1enHHaJIb H B03HJIoH (1934)
H Ap. Ho IIJIaHType, 30eKTHBHbI 1-2 HH'beKuHH CbIBOpOT'KH B3p.oC
JIbIX co6aK, TaK KaK OHH 06bILIHO co,gep3KaT TIYMHble allTHTeiia. A. Ko-
pOTHTI H Ap. (1939) yCTaHOBHJIH, TITO ycnex JIe'eHHH CbIBOPOTKOii
co6aK-peKOHBaJlecueHTOB 3aBHCHT OT CTeneHH H xapaxTepa 3a6o-
JIeBaHHH H BpeMeHH, HCTeKUlero OT Haqajia 3a60JIeBaHHH go npHMe-
HeHHH CbIBOpOTKH. CBe3KHe cJlyTlaH - Ao 6 AHH 6oJIe3HH - JIerKO
BbIJIelmBaK)TCH HH'beKljHeli 10-12 MJI CbIBOpOTKH. J1a Ke B 3anynjeH-
HbIX cJlyTiaHx 6JIaronpHHTHO BJIHHeT OJjHa HH'beKILHH CbIBOpOTKH; no-
BTOpHble HH'beKIUHH yJIyTluialOT COCTOHHHe 60JIbHbIX H yCKOpHIOT HX
BbI3AopoBJIeHHe; B OCJIO}KHeHHbIX c iyTaaHX CbIBOPOTKa peKOHBaJIecueH-
TOB MaJI034x eKTHBHa.
B. A. TpOIUHXHH (1940) C XOPOIIIHMH pe3yJlbTaTaMH npHMeHHJi
Ae(pH6pHHHPOBaHHy!o KPOBb peKOHBaJIecueHTOB, nwiyTIaeMylo y J[OHO-
pOB H3 He60JIbUIorO Hajpe3a KpaH yxa, r.e HpoxoAHT v. cranialis.
HO HaUIHM AaHHbIM (E. C. i-1epKaCCKHI%I, 1950), npOTHBOTIyMHbie
HMMyHTeJIa XOTH H COAep}KaTCH AJIHTeJIbHbII3 CpOK B KPOBH nepe6o-
JIeBUIHX co6aK, ORHaK0 HX THTP 3HaTIHTe.IbHO KOJIe6JIeTCH, nO3TOMy
Jlege6Ha5 aKTHBHOCTb CbIBOPOTOK peKOHBaJIecueHTOB pa3JIHTIHa H uIH-
pOKoe npHMeHeHHe HX MaJlogeJIecoo6pa3HO.
flepeJlHBaHHe KpOBH H ayToreMOTepanHH
B BeTepHHapHOIi n;paKTHKe nepeJIHBaHHe KpOBH, K CO}KaJIeHHIO,
npHMeHHeTCH cpaBHHTeJIbHO MaJIO, TIT'O He CTOJIbKO 06'bHCH54eTC5j Tex-
HHT-IeCKHMH TpyAIiOCTHMH, CKOJIbKO He1[ooueHKOI3 3TOro McTOJ[a.
HOMHMO o6ujero yKpenJieHHH 6oJIbHoro opraHH3Ma, nepe.iHBaHHe
KpOBH no A. A. BoroMOJibuy fOBbIUIaeT HMMYHOJIOrH'eCKyIO peaKTHB-
HOCTb 6OJIbHbIX, aeffCTByeT Ae3HHTOKCHuHpyIOwHM o6pa3oM, YCTpa-
HHeT pa3JIHTIHbie OCJIO}KHeHHH.
Ho aaHHbIM O. H. MaCJIeHHHKOBOI3 (1934), Tiepe3 HeCKOJIbKO TIa-
COB riot ie nepeJIHBaHHH KpOBH y co6aK Ha HCCKOJIbKO HeJjeJlb B 5-9
pa3 yBeJIHT-IHBaeTCH CparoUHTapnaH aKTHBHOCTb JIeH"KOIUHTOB, nOBbI-
iuaeTCH B 3-4 pa3a OnCOHHTIeCKHI3 THTP H arrJIK)THHauHOHHaH CIIO-
CO6HOCTb CbIBOpOTKH, a TaK}Ke o6a aH pe3HCTeHTHOCTb K HHCpeKL[HH.
liepe.IHBaHHe KPOBH aeceHcH6HJIH3HpyeT opraHH3M TIyMHOI1 CO-
6aKH. OHO HBJIHeTCH Ba}KHbIM (JaKTOpoM cneuHq)H IeCKOI3 CepoTepa-
nHH, eCJIH ,gOHOp - B3pociia5i co6aKa, paHee nepeHecuIas TIyMy.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MHOrHe aBTOpbI HOJIyxIHJIH xopoHIHe pe3yJlbTaTbI OT ITpIMeHeHHH
npH ~iyme IIJIOTOHAHbIX C06CTBeHHOFI KpOBH 60JIbHbIX co6aK HJIH
roMOJIOrHLIHOII KPOBH (M. A. ,Uy6HHCKHI'I, 1913, JIHXTeHlUTepH, 1921,
HeFIMaH, 1925, BeKbIO, 1926 H Jp?)
BeKbfo BBOA14JI B 3aBHCHMOCTH OT Beca Te.na 60-150 MJI KpOBH
nOJlKO}KHO, 20-50 ma IIHTpaBeH03110; nepeJiH3aHHe nepeIIOCHIJIOCb
JIeI'KO: H3 20 cO6aK, CTpaAaBIUHX CyAOporaMH C napaJIHLIaMH H noJly-
'IHBInHX OT 3 Ao 6 HI1'beKLwci KPOBII, 11 Bb13AOpOBeJIo.
AyTOreMOTepannH uyMbI B 23 H3 28 crlygiaeB H. H. O3epcxoro
(1927) AaJIa noJIO?KHTeJIbHbIfI pe3yJIbTaT noc ie 2-3 nOAKWKHbIX
HH'beKw iu no 5-10 MJI LHTpHpOBaHHOH KpOBH, B3IITOfI Y 3TOI1 1Ke
co6aKH H3 V. sophena HJIH H3 cepiua; noc ie BBeJeHHSI KpOBH Ha6Jlfo-
AaJIOCb HeKOTOpoe yxy,glueHHe, BCKOpe cMeHHBlueecx pe3KHM yJIyu-
IueHHeM.
AyTOreMOTepann9, no uannbiM B. B. I4aCOBHHKOBa (1930), JaeT
Xopow e pe3yJIbTaTbl TOJIbKO Y MCJIKHX CO6aK. ABTOp yKa3bIBaeT,
LITO B32Tb KpOBb H3 BeHbI Y MOJIOAbIX meHKOB Tpy.BHO, a H3 cepaua
onacno. OAHaKO B Hanlefi JIa6OipaTOpHH 6bIJIa IIpHMeHeHa cepAe'IHaH
nyIIK11HSi y HeCKOJIbKHX COT co6aK 6e3 BCHKHX OCJIO}KHeHHI{.
Ho MHeHH10 I'a6epJI51, AHApe (1933), HJIaHType, HCHOJIb3OBaHHe
KpOBH CO6aK, nepe6oJfeBIUHX 'IyMOf%I, AaJIO MaJIOOIn,yTHTeJlbHble pe-
3yJIbTaTbI. HanpOTHB, Ka6acco (1937) ycneluno BJIHBaJ1 B v. sophena
I.FITpnpOBaHHyfo KpOBb Co6aK, Bb13AOpOBeBHIHX OT TdyMbI, B35ITYIO
1YHKuHe1i CepI ua. 1_0p3 H JIeJfaHAe (1938) nOKa3aJIH, LITO 3KCTpaKTbI
H raiieTbl, IIpHCOTOBJIel[Hble H3 KpOBHHbIX CryCTKOB OT rHHepHMMyHH-
3H;pOBaHHbIX 11 TOTaJIbHO o6eCKpoBJIeHHb1X Co6aK, TaK}Ke o6JIaaa1OT
Jleue6HbIMH H Ilpo(~HJIaKTH,4eCKHMH CBOYICTBaMH. K CryCTKaM KPOBH
J1,o6aBJI2IOT (1)H3nOJIOrH'ICCKHII paCTBOp B TOM }Ke KOJIH'leCTBC, CKOJIb-
HO 6bIJIO nojlygei[o cbIBCpoTKH. 3aTeM CFYCTKII pa3MHHaIOT, B36aJ1-
TbIBaIOT H OCTaBJISIIOT Ha 24 ilaca B JICAHHKC, nOC.ne oei,o neliTpH-
(4)yrHpyloT. HoJ1ytlenHaH np03paiI1la51 }KHJI1KOCTb KOHCepBHpyeTCB
(OpMaJIHHOM (1 : 1000) H HarpesaeTCn B Te'eHHe naca npH 56? ABa
Allft noJIp5J H npnMeHSIeTCSI B AO3e 10-20 M,n.
flepeJinBaHHe KpOBH 60JIbHbIM 'IyMOii Co6aKaM yCneLuHo npHMe-
HTLnH C. A. baCKaKOB (1940), B. A. BbICTpoB (1940), R. T. KpacnoB
(1946) H Ap. B KaqeCTBe ROHOPOB HCnOJIb3yFOTC5I CTapble, He BOC-
npnHMTIHBble K uyMe co6aKH. KpOBb 6epyT H3 art. femoralis, UHTpH-
py[OT, npOBepiIIOT na COBMeCTHMOCTb H BJInBalOT B yLHHble BeHbI
peunnHeHTa. Ham OnbiTbi HoATBep}KJaIOT, LITO TpaHC()y3HH ocyH.[e-
CTBJISIeTCSi JIerKO H CTepHJIbHO, 6e3 TpaBMbI AJISi 60JIbHOro McHBOT-
IlOFO.
HocJIe nepeJlHBaHHSI KpOBH y 6OJIbHbIX C06aK BOCCTaHaB.JIHBaCTCSI
anIICTHT, noIIH)KaCTCF 'reMIICpaTypa, yBCJIHLIHBaIOTCn reM0rjl06Hl[ na
12 20%, 31)HT1OILHTbI na 20-301)o H JICHKOKIITbI Ha 40-101)%.
Ho 1Ia6JIIo/[CHIIHM BaCKaKOBa, nepe.nHBaI[He KpOBH 3(1)(j)eKTHBHO
npH noJOCTpoM H XpOHH'ICCKOM Te'-IeHHH 6o.ne3HH, a npH OCTpON
(JiopMe B rlauaJle 60JIe3I1H HepCAKO HpOBOuHpyeT JIeTa.JIbIIbIH HCXOA,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
-qTO coanaaaeT c Ha6JIIoAeHHHMH H yxa3aHHeM X. X. B.naAoca (1939)
o Heuealecoo6pa3HOCTH HepeJIHBaHHH KPOBH npH ocTpoM TeLIeHHH
HHCpexuHH B CTaAHH allepFHH H rllnepepraa. Ho coo6meHHIO BblcTpo-
Ba, 27 H3 28 YyMHbIX co6aK Bbl3AOPOBeJ10 OT OAHOKpaTHOPO nepeJlH-
BaHH5I 6OJIbIHHX A03-200 MJI LHTPHPOBaHHOI3 KPOBH peKOHBaJIec-
ueHTOB H OAHOBPeMeHHO 10 MJI HOpMaJIbHOI3 JIOLHaAHHO13 CbIBOpOTKH.
ABTOP CgHTaeT, 4TO y co6aK-AOHOpOB B OAHH npHeM MO}KHO 6paTb
H3 art. femoralis 200-600 MJI KPOBH H Llepe3 2-4 AH51 HOBTOpHTb
KPOBOnyCKaHHe.
flepe.nHBaHHe TaKHX 60JIbLIHX KOJIHLIeCTB KpOBH, no HaIHHM AaH-
HbIM, He BbI3bIBaeTCH HeO6XOAHMOCTbIO. IIpH 3TOM COBep1ICHHO H3-
JIHLHHe OAHOBpeMeHHOe BBeAeHHe HOpMaJIbHO13 JIOIHaAHHOFI CbIBO-
pOTKH.
Ilo FO(~MaHy (1942), Aec)H6pHHHpOBaHHa5I KPOBb npH LIyMe
co6aK Aei CTByeT aKTHBHee, He}KeJIH CbIBOpOTKa.
l'l3BeCTHbII3 HHTepec npeACTaBJISIeT yKa3aHHe PeMJIHH}Ke (1933),
HCXOAHBLHero H3 aaHHbIX H14KOJIJI1 (1931) 0 B03MO}KHOCTH HCHOJIb-
3OBaTb KPOBb LIeAOBexa AJIH npOTHBOLTyMHOI1 HH-beKUHH. UJI51 3TOro
HaAO BBeCTH co6aKe HOAKO}KHO 10-20 MJI KpOBH H HH-beKUHH npo-
BOAHTb e}KeAHeBHO HJIH LIepe3 aeHb. AMHO (1936) BbIJIeLIHJI LIyMy
co6aKH BHyTPHBeHHbIMH HH-beKuHSIMH KPOBH ee XO35IHHa.
AHTH6aKTepHNHble CbIBOpOTKH
HOLITH BCe aHTH6aKTepHriHble CbIBOpOTKH, HpeAJIOx{eHHble m
JIe'IeHH51 L1yMbI Co6aK, 6bIJIH HCHOJIb3OBUHbI B ueJInX Hpocp[JIaKTH-
KH LIyMbI H C03X]HH9 HCKYCCTBeHHOPO HaCCHBHOFO HMMyHHTeTa (106-
JlaHep, 1900, Maiep, 1902, flHOpxoBCKHFI, 1903, 1910, BepHAT, 1911,
peHHep, B. S13bIKOB, 1928 H up.). PeKOMeHAOBaJIOCb (FOJIbTOp6ax,
1912) B HJIeMeHHbIX XO3HcICTBaX e}KeMeC51LIHO HPHBHBaTb IueHKOB,
HaLIHHa51 c 4 Ao 20--24-Heae.nbHoro B03paCTa. flpo(pHJIaKTHLIeCKy1O
ueHHOCTb 6aKTepHHHbIX CbIBOPOTOK OTPHuaIOT IIyTKaMMep, FHCaMK
H EOA3H (1908), M. M. MaJlbueB (1908), PHxTep (1908), U>KaKo6
(1911), BepBei (1911) H ap? XOT51 6aKTepnliHble aHTHCbIBOpOTKH
H He3(1(1)eKTHBHbI KaK CHeUH(pHKyM HPOTHB HyMbI HJIOTOAAHbIX, ojHa-
KO OHII CH0006HbI HpeAyfpeAHTb HJIH CMSII-IHTb OCJIO}KHeHH51, BbI-
3BaHHb1e CeKyHAapHOli (pJ1OPOI, H03TOMy HX HPHMeHeHHe B KOM6HHa-
uHI1 C aHTHBHPy.'HbIMH Cb1BOPOTKaMH BHOJIHe ueJlecoo6pa3Ho. flpH-
MCHeHHe ?lie HOpMaJ1bHOFI JIOIHaAHHOII CbIBOPOTKH (C. A. F5apaxoB,
1935), Hp0THBOCKapJIaTHHO3HOI-I J1oHIaAHHO1'1 CbIBOpOTKH (K. H.
111epCTO6oeB, 1946), CbIBOPOTKH HPOTHB CH6HPCKON H3BbI (JI. K. ,La-
HHJIOB, 1953) HMeeT 3HaLIeHHe TOJIbKO KaK npOTeUHOBOe pa3Apa)xe-
HHe, CTHMyJIHpyIoLuee HeCHeu1(1HLIeCKy1O pe3HCTeHTHOCTb K HH-
{peKuHII.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
AHTHBHPYCHbie H HOJIHBaJIeHTHble aHTH6aKTCpHHHO-BHpYCHble
CbIBO11OTKH
3HreH, OpJIOB n upyrme 3KCHepHMeHTaJIbHO ZIOK33aJIH BO3MONK-
HOCTb HCKYCCTBeHHO C03AaTb HaCCHBHbIH HMMyHHTeT HPOTH3 'IyMbI
nJ10TOBAHbIX. TaK, rHHHepHMMyHHble K03bH CbIBOPOTKH 3HreHa B
Ao3e 6 MJI npeuoTBpaluaJ1H 3KCHepHMeHTaJIbHOe 3a6oJIeBaHHe. Ho
OpnoBy, 5 MJI Co6a'beii rnHHepHMMyHHOIH CbIBOPOTKH cooOlualoT
LueHKaM naCCHBIlbIH HMMyHHTeT, HpeuoxpaH5 ouiH HX B TeueHHe
9 AHe! OT 3KCHepHMeHTaJIbHOro H KOHTaKTHOrO 3apaA{eHHH 4yMOH.
I-IOJIHBaJIeHTHa5I CbIBOpOTKa no MauyKKH 3(~,(N)eKTHBIIa B u03e 10-20
MR. B 61,5% npeuoxpaH5leT fPIIBHTbIX co6aK OT
'IyMbI (JIoI xapiT H up.), a no CKHAMOPy n byKilelo (1926) -
TOJIbKo 22,2%.
I-IOJIHBaJIeHTHaH C06a'lbf CbIBOPOTKa Hycx3ra H I.IITOKepa B AO3e
10-20 MJI coo6nlaeT co6aKaM UMMyHHTeT npo;iomKHTeJIbHOCTbIo
B 10-14 AHei. FFInnepHMMyHHaFi co6a'bHi CbIBOpOTKa KoIneBoro
OKa3ajlacb 3(jcpeKTHBHOH AJI51 npHBHBKH co6aK, HaXOAHmiiXCH a
He6JlaronoJly9HbIX no tiyMe Xo351fiCTBax.
Ho AaHHbIM Byua (1929), HpHBHBKa 10--20 MJI rHnnepHMMyHHOH
co6a'be13 ChIBOpOTKH Co3AaeT y co6aK naCCHBHbIH HMMyHHTeT K '1yMe
CpOKOM Ha 10-20 AHeA, a JiouiaAHHa5i CbIBOPOTKa beMeJibMaHa
(1930) He3(p(1eKTHBHa. FHnepHMMyHHaSi CbIBOPOTKa JIelAJ10y H T~e1i-
KHHa B Ao3e 4-10 MR Co3uaeT HMMyHHTeT np0AOJI?KHTeJIbHOCTb1O
8 AHei. CbIBOpOTKa JIHTTJ12 B u03e 4 MJI C03AaeT y nOACOCHbIX meH-
KOB HMMyHHTeT npH6JIH3HTeJIbHO Ha HeueJiIEO, KOTOpbIH nOBTOpHbIMlt
npFBHBKaMH Mo}KeT 6bITb Hp6uJIeH. PeMJIaH}Ke (1933) c'iITaeT, '4TO
AOCTaT04HO OAHOH HH'beK1IHH geJIOBe'IeCKOH KpOBH. 'ITo6b1 0006HIHTb
co6aKe HenpoAoJDKHTeJIbHbIH naCCHBHbli3 HMMyHHTeT K IIyMe. Ilpo-
THBOilyMHa5l co6aL1bH CbIBOPOTKa FJJIaHType coo6waeT IIpHBHTbIM
co6aKaM HaCCHBHbIH HMMyHHTeT Ha 2-3 HeueJIH (MaK KFHH, 1936).
Flo B. A. Tpoinnxuiiy (1940), uecTH6pHHHpoBaHliaR KpOBb co6aK-
peKOHBaJlecueHTOB B A03e 10 MR npeAOTBpaTHJIa 3a60JIeBaHne 17
Iuel{KOB, KOHTaKTHpOBaBIHHX C LIyMHbIMH cO6aKaMH. ABTOP peKOMeH-
uyeT B Ka}KAoM nHTOMIIHKe COAep>KaTb HCCKOJIbKO co6aK-AOHOpOB.
110 I'yTHpa, MapeKy H APyrHM (1954), CbIBOpOTKa Feirepa B u03e
2-3 MR Ha I Kr Beca a(~(j)eKTHBHa AJTSI naCCHBHOH HMMYHI13auHH
co6aK.
npOAOJI}KHTeJIbHOCTb H HafpsvKeHHOCTb naCCHBHOTO HMMYHHTCTa
,qJISI yCTaHOBJIeHHSH upOA0J1}KHTeJIbHOCTIi n HanpmKeHHOCTH nac-
CHBHOFO HMMyHHTeTa, coo6nuaeMoro liauieii rHnepHMMyHHOH CbIBO-
poTKOH, 6b!JIa HOCTaBJieHa cepl !i OnbITOB. jJmm npHMepa npHBOuHM
oAHH H3 OnbITOB, HOCTBWIeHHbIX B HK)He 1950 r. Ha 22 iuelixax 3-4-
MccngnOro Bo3paCTa. IHCCTHauu ITH LueHKaM 6bIJIa BBeueHa 8 HIOH5I
rnnnepHMMVHHaH CbIBOPOTKa B A03e 0,5 MR Ha I Kr Beca; 6 1ueH-
KaM BBeueH Bb!COKOBHpyiTeHTHbIH BHPYC B A03e 4 MR. IUeHKH, npHBH-
Tb1e CbIBOPOTKOH H 3apa}KeHHbie BHpyCOM, 6bIJIH pa3MeiueHbl o6oco6-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIeHHO. HaqHHa5I C 9 HIOHH, Yepe3 Ka3KRbie 2-3 aHSI Ka}KaO 1 nape
meHKOB, nipHBHTbIX CbIBOpOTKOId, BBOAHJIC51 BbICOKOBnpyJIeHTHbII1
BxpyC B 903e 4 MJI. McHKH TOTtiac }Ke nepeBORHJIHCb B 3apa3Hoe
noMeHleHHe, r,e coaep}KaJIHCb BHpyCHble co6aKn, 6 IUeHKOB, 3apa-
}KeHHbIX 8 141OH51, CJIy}KHJIH KOHTpoJIeMI (Ta6Ji. 20).
Ta6JIHI.ia 20
rlpOAoJIWHTeJIbHOCTb H HanpclweHHe naCCHBHOrO HMMyHHTeTa,
coo6iuaeMoro rHnepHMMyHHOti CbIB0pOT1uot'f noJlyveHHOt1
aBTOpOM 0O yCKOpeHHOMV McTO1
IIe3yJIbTaTbl
CnbITa
i1aTa BBe-
ZI03a
.II,aTa KOHT-
1(eHH9 CblBO-
CbIBO-
pOJIbHOiO
O
K
o
a o
POTKH
pOTKH
x S
O, p.,
3apaaceexa
v
E--d
K
NO
Or,
0
O
xm
N
Un.
S
~m
co
M
M
q
N
mw
2
8/VI 1950
0,5 Mn
41
9/VI 1950
?A>tceK"
4 Mn
-
-
-
2
8/VI 1950
Ha 1 Kr
41
12/VI 1950
4 ,
--
2
8'VI 1950
41
15/VI 1950
4 .
-
-
2
8/VI 1950
41
17/VI 1950
,
4 .
-
-
-
2
8/VI 1950
41
19/VI 1950
4,
1
-
1
2
8/VI 1950
41
21/VI 1950
4 ,
-
-
-
2
8/V1 1950
41
23/VI 19F0
4.
2
1
1
2
8/VI 1950
,
41
25/VI 1950
4 .
2
2
-
3
13, 14 H
15/VI 1950
41
8/VI 1950
,
4 ,
3
-
3
3
21,221
23/VI 1950
41
8/VI 1950
4,
3
1
2
KaK BHRHO H3 aaHHUX, npHBeJI HHbIX B Ta6J1. 20, ORHOKpaTHoe
BBeReHHe rHnepHMMyHHOI3 CbIBOpOTKH coo6waeT IueHKaM Hanp i-
}KeHHb113 naCCHBHbIcl HMMyHHTeT K 3KCnepHMeHTaJIbHOMy 3apa)KeHHIO
4yMOII. OH HacTynaeT y npHBHTbIX CbIBOpOTKOFI Ii[CHKOB y}Ke 9epe3
CYTKH H ,JIHTCSI aO 10-15 aHeg, aOCTHra5i HauBbicuIerO Hanp5DKeHHA
MeacRy 1 H 11 RHeM.
Bce 11 H HKOB, He 3a60JIeBIII-X ripe KOHTp0JIbHOM 3apa}KeHHH,
B nocJieaylomr1e 5-6 MeC. T3K}Ke He 3a6oJIeJIH HH OT KOHTaKTa C
BHpyCHHKaMH, HH npH 3KCnepHMeHTaJIbHOM 3apa}KeHHH. OHH OKa3a-
JIHCb KaK 6bI CHMYJIbTaHHO npHBHTbIMH. HeKOTOpble H3 HHX 6bIJIH
BHOCJIeRCTBHH rHnepHMMYHH3HP0BaHbI yi o6eCKpoBJIeHbI.
3TH H apyrHe OnbITbl fOKa3aJIH, qTo HaCCHBHbIFi HMMyHHTeT K
KOHTaKTHOMy H 3KCnepHMeHTa.1IbHOMy 3apa}KeHHIO HMeeT pa3JIH4HYI0
IIpoaoJ1}KHTeJIbH0CTb, KOTOpaft COOTBeTCTByeT a03e CbIBOpOTKH H
uaCTOTe ee npHMeHeHHST. Corjiacllo BpeMeHHOMy HaCTaBJIeHHK),
I rIOCJIe Toro, KaK OHH 3a60JIeiiH, Ha HHX HCHbITbIBaJIOCb JIege6HOe AeNCTBIle
CbIBOpOTKH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
yTBepxK,ReHHoMy rJlaBHbIM ynpaBJlenHeM BeTepHHapvH MCX CCCP,
HaIHa CbIBOPOTKa BBOJ[HTC51 C npoCJuJIaKTH4eCKOIi LjeJIbIO B TeX )Ke
jj032X, LITO H Jjji5i JIe4eHH51 (CM. CTp. 235), HO OJjHOKpaTHO. B npOH3-
BOJ(CTBeHHbIX YCJIOBHHX naCCHBlibie IIPHBHBKH npeajio>KeHHOft Hamm
rHIlepHMMyHHOii CbIBOPOTKH TaK}Ke AaJIH nOJIO)KHTeJIbHbie pe3yJlbTa-
TbI. B OJHOM fHTOMHHKC H3 70 co6aK, naCCIBHO npiBHTbIX Hp0THB
L1 MbI HaHIeci CbIBOpOTKOIi, HH OJHa He 3a60JIeJia njH KOHTaKTe c
60JIbHbIMH, B TO BPeMH KaK Bce 11 KOHTpWJIbHbIX co6aK 3a60JIeJIH
,iyMoi-i. B yro.IiKe HM. aypOBa H3 OJjHOKipaTl-10 npHBHTbIX 30 co6aK
14 5 eHOTOBHJHbIX co6aK He 3a60JIeJIo HM OJLHO }KHBOTHoe, XOTII BCe
HMeJIH KOIITaKT C LIyMHbIMH CO6aKaMn (B. A. HBaHOB). AHaJIOrHLIHble
pe3yJibTaTbl HOJIyLIHJIH BeTBpaciH IIIO6CKH1I Ha 4 co6aiaX, CeJIe3HeB
Ha 6 Co6aKaX II ap. CpejwH }Ke HeHpHBHTbIX Co6aK, HaXOJjIIBLHHXC51 B
KOHTaKTe c 6OJIbHbIMH }KHBOTHbIMH, 3a6oJIeBaeMOCTb HyMOH JOXO-
,aHJla Jo 60-70%.
11accHBHa51 HMMyH113aUHH MO)KCT IIMeTb Ba)KHOe npaKTwLIeCKoe
3HaLIeHHe B He6J1aroIIOJIy4HbIX no LIyMe XO3HI4CTBaX, CHOCO6CTBy51
COKpaLHeHHIO Pa3MCPOB OH30OTHH it 06pa3OBaHHIO HMMyFIHOI4 np0-
CJIOHKII 3a CLIeT KaK 6b1 CHMyJIbTaHHO HpHBIITbIX Co6aK.
IlaCCHBiible HPHBHBKH C npo[JHJIaKTFI4eCKOFI LjeJlbiO Hajjo npOBO-
JjHTb IIpH IICpeBO3KaX HeIIMMyHHbIX Co6aK H LjeIIHbIX HyLHHbIX 3Bepei3,
HpH HX 3KCnOIIHpOBaIIHH Ha BbICTaBKaX, ygaCTiIH B BbIBOJIKaX, 000T513a-
IIHflX H B AjNFHX MCCTaX KOHLjeHTpaL[HH C06aK, rJje BCeraa IIMeeTC51
OHBCIIOCTb HH(PHLjFpOBaHH51.
11aCCHBHa 1 HMMyHH3a1tH 1 raMMa-rJ106yJIHH0M
,BeNAJioy H JIeHKIIH (1931) nOKa3aJIH, LITO npOTHBOHyMHbie
ailTHTCJIa COJjepaiaTCH B rJIo6y.7IIiiiaX CbIBOpOTKH, H CAeJIaJlii HOIIbITKII
IIX OlIICTKH 11 KOIIIUCIITpaI1IIH.
JhpHII (1954) JjeTa lH3NpOBa,ii 3TH JjaIIIIbIC H yCTaHOBHJI, LITO
IIyMHhIC aIITHTeJia aCCOLIHpYIOTCF C raMMa-r.IIo6yJIHIIonoH (1)paKL[HCH
CbIBOpOTOLHibIX HpOTCHHOB. 113 400 Co6aK H3CCIIB11O HMMyIIH3HpOBaH-
HbIX I'aMMa-rJIObyJIHHOM (COAep7KAT B 10 pa3 6oJIbLHe al{TIITeJI,
11e3 CJUI B CI>I13O9OTKC), 262 (65,8%) pcarnpoBaJiH HoBbIIIIeiimeM
TCMIiepalTypbl Jjo 40" It BbIIIIC C KJIHHHLIeCKHNIH CHMHTOMaMH 60JIe3HH,
a 3 (0.75%) najiH OT LIYMbI H 0e OCJIO}KHeHHIi. TIapHH Ii XOJj7KMeH
(1954) yCHCIIIHO HMMyHH3HpOBaJI4 raMMa-rJI06yJIHHOM 300 Co6aK.
CEPOTEPAnHSI H CEPOHPO(DHJIAKTHKA 4YMbI Y JIHCHIU, HOPOK,
EHOTOB H COBOJIEB
1'1MCIOIFHCCSI JjaHllble o CepOTepannll H CCpOHporf)IIJIaKTHKe LIyMbI
V pa3JIIILIHbIX BHL110B HyLHHbIX 3BepeFi B oft item HCMHOrOLIHCJIeIIHbI.
THnepHMMyHIIarI HpOTHBOLIyMHaH CbIBOPOTKa Co6aKH npr LIyMe
CHOTOEUIHbIX C06ak B JT03aX OT 6 AO 15 Ii.ri Jja.Tia oTpHI aTeJIbIIbIA
pe3yJIbTaT (H. MHpoJilo6oB, 1932). HMMyHIIaft npOTHBOLIyMHaB CO-
6aLIbSI CbIBO1OTKa f1QHAJioy H TtellKHHa, yCHCHIHO npFMeH5HoLua5ic5I
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
,RJISI np0(JHJIaKTHKH 4YMbI y FIOpOIC, JiaJta OTpHuaTeJIbHble pe3yJlbTaTb1
npH npHMeHeHHH ee c JIe4e6HOH ueJlbIO B JZ03aX 5 MJI MOJIO,I(bIM
HOPKaM H 7,5 MJI--CTa!pblM (1IIOy, 1932, KJI03, 1937).
OTTO (1939) yC I IJIHO JIe'-IHJI LIyMy y JIUCUI4 rInepHMMyHHOII
co6agben CbIBOpOTKOH; CMepTHOCTb CHH3HJIaCb c 22% go 11 %.
COIJIaCHO a HHbIM XHJiJIa H apyrHx (1942), Y 3BepeH, npHBHTbIX
CbIBOpOTKOH, naccHBHbIH HMMyHHTeT K KOHTaKTHOH HHIpeKUIIH KpaT-
KOBpeMeHeH H Y XOPbKOB He IlpeBblInaeT 9 J[HeA. 1IO3TOMy nDM
BCnbIHIKax LIyMbI Ha 3BepOBOIIHeCKHX cpepMax ueJIeCOO6pa3Hbl no-
BTOPHble npHBHBKH. CbIBOpOTKa FeHrepa HPHMeHReTCH C nPo(JHJIaK-
THLIeCKOH ueJIbio B Ja03e 8 MJI, a c Jiege6HOH-15 MJI Ha roJIoBy
(I'yTHpa H apyrHe, 1954).
FHnepHMMyHCbIBOpOTKa Hanlero H3FOTOBJIeHH5I 3 J(peKTHBHa AJH1
IIpo())HJIaKTHKH H JIegeHHn LIyMbI Y JIUCUI.{ H 60AKCO6 (B ,g03e 5-10
MJI) H co60JIec. 143 28 TH)KeJIo6OJIbHbIX co6oJleu, KOTOpbIM 1-2
pa3a nOJIKO}KHO 6bIJI0 BBej[eHo no 2,5-3 MJI CbIBOpOTKH, BbI3,aOPO-
BeJIo 23 (CBbinle 82%), B TO BPeMH KaK naJIH Bce 24 600bHbIX co6o-
JIH, He fOJIyLIHBHIHX CbIBOPOTKy H JIeLIHBHIHXCA HOpCyJIbq)a3oJIOM,
o6JIyLIeHHeM KBapueM H up. (100 % CMepTHOCTb). KpOMe TOFO,
6bIJIH nppejioxpaHeHbl OAHOKpaTHbIM BBeaeHHeM CbIBOPOTKH 59 co6o-
iieH, 3a60JIeBaHH51 cpeuH KOTOpbIX, HeCMOTPH Ha TeCHbIH KOHTaKT C
60JIbHbIMII, npeKpaTHJIHCb (C. E. CopHHa, 1953).
HepeJlHBaHHe KPOBH
T. R. BaHHOBCKHH (1')41) nepeJIHJI uHTpHpoBaHHyIO, npoaepennyl0
Ha COBMeCTHMOCTb KPOBb PeKOHBaJIeCueHTOB 9 60JIbHbIM JIUCUI.1aM
(no 20 MJI KaNCAOH), H3 HHX 8 Bb13,TjOpOBeJIO, a 1 nana.
HopMa.mHa9 CbIBOpOTKa CO6aKH
B onblTax BaHHOBCKOrO H ,L pyrex I IPH npHMeHeHHH HOPMaJIbHOA
co6aLlbec CbIBOPOTKH Ha 26 B3pOCJIbIX cepe6pncTO-LlepnbIX nuculyax
B 80% 6blJl noJlyLleH nOJIO}KHTe.TIbHbIH pe3yJIbTaT. CbIBOpOTKa BBO,gH-
Jlacb 1-2 pa3a B ,/O3ax 15-20-30 MJI. B apyroM cJIyLIae, npH JIe-
LIeHHH 9 60JIbHbIX JIHCbHX HjeHKOB co6aLIbeH CbIBOpOTKOH Bbl}KHJIO
TOJIbKO 5 rOJIOB, a H3 9 KOHTpOJIbHbIX-2.
HopMaJIbHa l CbIBOpOTKa JIowaJ[H
MHp0JnIo6oB npH L1yMe eHOT06UdKbIX co6aFC HOJIy'IHJI OTpnua-
TeJIbHble pe3yJIbTaTbI OT 2-3-KpaTHoro npHMeHeHH1 HOpMaJIbHOH
JIOHIa,JHHOH CbIBOPOTKH B ,g03aX OT 3 ,I);O 4 MJI. B OnbITaX 1Ke BaH-
HOBCKOrO Ha 60JIbHbIX LIyMOH 56 cepe6pHCTO-LlepHblX Jluculyax B
85% noJlyileH nOJIO}KnTe.TIbHbIH pe3y.TIbTaT. CbIBOpOTKa BBO,XHJIacb
HOj[KO>KHO B Ha4aJIbHOH CTa,IHH 6oJIe3HH B J[O3e OT 1 no 3 MJI, B
OTJgeJIbHbIX c.nyLlaHx HH-beKIHH noBTOpHJIHCb ,g0 5-7 pa3.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BAKILHHOTEPAHHg
IZepBble BaKn.HHbI, npHMeHBBIII11ec5I JjJ1fl JIe'IeHHSI co6aK, 6oJIb-
libIX 4yMoO, 6bIJIH npH1OTOBJICHb1 H3 6aKTep11f1.
(D n3aJ11IKC 11 Pa66e (1903) o6Hapy}KHJIH, 1TO npIIBHBKa BaKUHHbI
co6aKaM, yxtie 3a6oJIeBIIIHM nyMO{l, yilygruael' TegeiiHe 60JIe3HCHHOrO
upollecca. JIHHbep (1903) 3T0 oTpnuaJI.
B OHbITaX J. H. 11oTeXHHa (1912) BaKUHHa aMepHKOIICKOcI (j)Hp
MbI ParKe, Davis a. Co. gajIa B 061ueM no.TIo)KHTCJIbubIii pe3y.lbTaT.
O;1HaKO 11. :)KKCpT (1915) BbICTy[IHJI HpOT11:3 Ce HpHMC1ieHHH, KaK
11e113nec,moro no coc any cpeJjCTBa.
1I)cppil (1912) npejuiounn.n .,ie'Ie6iiyio no.nHBaJieHTHylo BaKnuHy
H3 cMCCH Bact. bron(hoseptie'us, Streptococcus aurcus, Streptococcus
pyogenes, Staphylococcus pyogen alb. H3 npHBHTbIX cO6aK BbI3JgO-
poIICJIO 78,1 7 Ii iioin6JIo 21,90/p, TOr, a KUK AO I1PH311BOK CMCPTIIOCTb
AOCTIIIUJla 60-90%. Bai iwno0 113 Bact. bronchosepticus ycneiuiio
Jle'IHJI 'IyMHbIX CO6UK TyTT (1924). HwieKu:a.I nOBTOpAJIaCb Ha 4
JLeub. Ho IILTIHHOMaHy (1925) 1aBYKpaTHa2 IIpHBIIBKa BaKII.HHb1 H3
Bact. bronchosepticus CTpCHTOKOKKOB FI CTa(j)IIJI0KOKKOB OCJIa6JIHeT H
yCKOP20P Teneuue 'iyMbi.
PaMO30TTH (1925) peKOMeHAOBaJI JJ1B JIewHFIH IyMHbIX CO6aK
BaKUHHy no MauuyKFi (1925) H3 y6HTb1X 3(JHpoM Bact. coli comm.,
Bact. septicaemia hacm., CTpefTOKOKKOB H cTaCpHJIOKoKKoB.
MrJ1ei (1926), Po6HH H Mrjiej (1928) npoBeTIH o6FHHpHbie
OIIbITbI Jle'Ie!!HH 'IyM11bIX C06aK ayTonHOBaKUFfHO13, npHFOTOBJICHHOII
H3 CeKpeTa abiXaTeJIbHbIX HyTec.
B JleIKFIX CJly'Ia ix 'IyMbI H B COe,rHHeHHH C OMHaJHHOM T aBaJla
9())(J)eKT rpHHKaJIeH-BaKUHHa 143 nauTO'IKH rpnnna A(paHaCbeBa-FI(pe%I-
()epa.
17pH nape3aX npFIMCH5IJIaCb BaKUHHa (FpH("IIT,
1930) H BaKUHHa BpyLueTTHHH (1934), npHrOTOBJIeHHaH H3 (pHJIb-
TpaTa Bact. prodigiosus, Bact. pyocyaneus, Streptococcus pyogenes,
Bblpaw.eHHbIX B M03rOBOIi cpe.r e; MaPTHHH (1934) 10 HHTpaTpaXeaJIb-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HbIMH HHbeKLIH5IMH BaKLIHHbI BpylueTTHHH HCueJIHJI T5i}KenyIo gyMy
(cy,.oporH nape3 3aaHHX KOHegHOCTel).
JIoxxapJ (1934), BpnoH (1938) npH TierotlHbix nopaxceHH5IX
peKOMeHAOBaJIH ayTOBaKuHHy H3 I-aKTePHH, BbIAeJIeHHbIX OT 6oJlb-
HOrO }KHBOTHOrO.
14HTpaTpaxeaJlbnoe npHMeHeHHe nOJIHBaJIeHTHoro 6aKTepHo()ara
(Mo.n.na, 1934) XOT51 H .a.lo nOJIOMKHTeJIbHble pe3yJibTaTbl, O,LHaKO
He nowiy4HJio pacnpOCTpaxeHH51.
B OHbITax Po6eHa H JlaypeHTa (1947) ripH HepBHbix npo5IBJIe-
S1H5[X 4yMbI 6bIJI 3(IHpeKTHBeH CTpenTOJIH3aT: H3 37 co6aK 20 BbI3,IIOpO-
BeJIo, a CocT05iHHe 17 yJIy4IIIHJIOCb. LIo IIITy6enpayxy (1947) BaK-
UHHOTepanHH VyMbI 6aKTepHHHbIMH BaKII,HHaMH Hex" eKTHBHa.
Xopouine J1e ie6Hble pe3yJlbTaTbI OT npHMeHeHH5I 6aKTepHFIHOIM
BaKIIHHbI C06CTBCHHOrO npHrOTOBJIeHHSI noJ[y4HJl T. A. KOHAaKOB
(1951).
B HacTOnnlee BpeMx B CILIA, B AHrJIHH, FUP H ApyrHx cTpaxax
B KagecTBe BcnoMoraTeJlbxoro cpeACTBa AJIA JIegeHHSI OCJIO}KHeHHII
;IyMbI npOH3BOXIT pa3JIH4Hbie BaKLIHHbI H3 MHKp060B - cnyTHHKOB
i-IyMbI BJIOTO51AHbIX.
JIE4EBHbIE 11PHBHBKH BHPYCHbIMH BAKLIHHAMH
B CCCP eUue B 1929 r. 6bIJIO o6paIUeHO BHHMaHHe Ha TO, 4TO
BBeJ eHHe HHKy6aTHKaM npOTHBO4yMHOH BaKLIHHbI no flyHTOHH He
BeAeT K yxyIIWeHHIO 60J[e3HeHHOro npouecca. B onblTaX CTioap'ra
(1930) noCJ1eAOBaTeJlbHble HHbeKuHH BaKLIHHbI JIeHAJIOy-AeHKHHa
rIpHBOAHJIII K Bbl3AOpOBJIeHHIO Ha iajlbHbIX CTaILHK 4yMbI. Cam }Ke
AeHKHH (1931) 6bIJI IIPOTHB 3TOI-0 H He COBeTOBaJI npHBHBaTb co6aK
C fOBbILIIeNIIOH TeMHepaTYPOH.
.Ie4e6HbIMIi CBOI''CTBaMH o6Jlaaaaa reMOBaKUHHa F. JI. Paa3H-
BHJIJIOBCKOrO (1933) : H3 BaKLIHHHpOBaHHbIX 11 HHKy6aTHKOB nano
TOJIbKO 3. C. C. KOTOB (1937) BBeJI reMOBaKLIHHy no PaA3HBHJIJIOB-
CKOMy 18 LLIeHKaM, HaXOAHBUIHMCH B Ha4aJIbHOH CTaAHH 6oJIe3HH.
Ha c.neuyioLUHiI ,LeHb nocJle BaKUHHaLIHH TeMnepaTypa y 16 LIjeHKOB
CHH3HJIaCb Ha 0.5-1,5?, 4epe3 5 aHeg H y OCTaJIbHbIX 2 LueHKOB.
ApyrHe KJIHHH4ecKHe CHMnTOMbI npoaoJuKaJIHCb ea e HeCKOJIbKO
AHeH, nocJie 4ero H1eHKH, KpoMe 0,RHOro, naBLuero OT 6pOHxonHeB-
MOHHH, Bb13AopOeeJIH.
HOJIO}KHTeJIbllbI[3 pe3yJlbTaT KOTOB nOJIy4I4JI B TOM MKe XO3HI4CTBe
npH BBeaeHHH BaKUHHbI 2 60JIbHbIM 4yMOH B3pOCJIbIM co6aKaM.
OnbiTbl Alo.laca (1934) no JIe4eHH1O 60JIbHbIX 4yMOI3 co6aK
BHpyCOM, HHaKTHBHPOBaHHbIM HarpeBaHHeM, 3(JHpoM, XJIopo(opMOM
HJIH (JopMaJIHHOM, aaJIH OTpHuaTeJIbHbIH pe3yJlbTaT.
LLIJIOTTrayap (1946) no.my4HJ1 xopoLuHe pe3yJlbTaTbI OT npHMeHe-
HH51 BaKUHHbI B [lepBble aHH noc ie 3apaMKeHHH. FpHH H LUTOJIb6epr
(1946) yxa3a.TH, 410 }KHBaH XOpbKOBa1 BaKUHHa B A03e 1-2 MA Ha
450 r Beca B paHHefI CTaAHH 6oJIe3HH AaeT npexpaCHblc TepaneBTH-
geCKHH 34xj eKT. ECJIH Me1KAy BBeAeHHeM BHpyJIeHTHOFO BHpyca H
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
npHBHBKO1i BaKUHHbI npoinno 6oJiee 3 ajieli, TO HHTep(pepeHUHn OT-
CyTCTByeT Ii 6oJ1e3Hb pa3BH4aeTCSI KaK 06bITIHO.
Ho BHpxeJllo (1947), Kpayiopay (1947), IOTyo (1948), Fop
(1948), Ipyna ay (1948), FJIeHHeIo (1949), Y.nbpnxy (1949) H r py-
FHM, BaKUHlIa I pIIHa J.iaeT JLege6HbIh 3()(jeKT. Bocce (1948) 3To
OTpHUaeT.
YcneLHHO nprMeHneTCH BO BpeMH BCHbILHeK HlyMbl HHaKTHBHpO-
BaHHaH (j)OpMOJIBaKUHHa H3 JIeFKHX H M03ra HyMHbIX co6aK (no
Kpeccy, 1952).
BaKUHHOTepanHn ilyMbl B3POCJIbIX JIHCLIU ii co6aK no3I Hee 10 RHH
3a60Jle3arIFrn, KaK coo6uin.n B. A. HaHKOB (1951, 1953), JzaeT nJIO-
XHe pe3y.nbTaTbl: 143 73 B3pOCJIbIX Co6aK H3JIetlenbl TOJIbKO 14. BaK-
UIIIIOTepanH9 TIIJCblIX LIICHKOB II MOJIO,11,IX JIHCHU B BO3paCTe OT 1,5
MeC. JO 1 rOJ[a 3 MeC. TaK ice He3(c(f)eKTHBIIa. Home BpcMeHII0r0 yTlytl-
LHeiIHn y 3BepeK uepe3 2--4 Heje.nM pa3BHBaIOTCA HepBHble HBJIeHHH,
3aKauHHBaIOLHHeCn cMepTblo. ABTOp peKOMeHJ or3a.I B paHHHX CTa-
,IjHSIX 3a60J1eI3aHII5I BBOJIlTb ero BaKUHHy no 2-5 MJI Ha HIPbCKLI,HIO.
JIoneu (1952), Cy)LyT (1954) H Jipyrre coo6LUH.nH o6 ycneruuoN
BaKUHHOTepanluH co6aK 9M6pHOH-BaKUHH0III H3 BHpyca tIyMbl nJI0T0-
5U HblX var. putorius, aAanTHpoBaxnoro K PK9. OAHaKO Ka6acco,
CTe66HHc H KOKC OTPHU 1EOT TepaneBTHtIecxne CB0 iCrBa BM6;pHOH-
BaKIIIIHbI.
B rraweM (LIepKaccKHi'I, 1950, 1951) onbiTe npuMelleHHn >KHBOH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TJIABA ILIECTHAAL(ATA5I
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B HepByio o'IepeAb AOJDKeH 6blTb yCTpaileH HAM, 110 Kpaibierr
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B nopa}KeHHH (pepMeHTaTHBHOfi cHCTeMbI 6aKTepHII, IJIaBHbIM o6pa-
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Kxe J03bf 6pOMa, AO HeCKOJIbKHX CaHTHIpaMMOB H Aa}Ke MHJIJIHI'paM-
MOB, a ca Moe 60JIbLHee - AO IIeCKOJIbKHX ueuHrpaMMOB Ha e]Ke)j1feB-
HbIII npHeM> . J1e4HTb 6pOMHCTbIMH npenapaTaMH MOIKHO He 04eHb
AOJII'o (3KCnepHMeHTanbHO AOKa3aHO n',pHBbIKaHHe), a c nepepblBaMH.
IIPH 3TOM HaAo y4HTbIBaTb BO3MO)KHOCTb nOHBJIeHH5i 6poMHCTbIX
cbinell.
B CBeTe y4eHHH 14. H. IZaBJIOBa, BnOJIHe ue.Iecoo6pa3HO KpOBO-
nyCKaHHe: OHO HBJIHeTCH (paKTopoM, pa3Apa}KaIOMHM HepBHO-peueIf-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
TopHhle npl6opbl Ii nopow,,aaiornHM pe(JJIeKTOpHble peaKIuHH. HCKJUO-
HFITeJ1I,HO BaiK}IOe 311a'-ICHHe HMeeT KOJ1HHeCTBO BbinvLueHHOH KPOBH,
CKC,pGCTb KpOBO0OTCpH, HCXO)jllOe (~yHKuHIOHaJlbHOe COCI'OSIHHe opra-
111I3Ma H npe>K,ae Bcero - ueHTpaJIbIIOH Hepaxo1 cuCTeMbi. McTOJI.
KpOBOIIyCKaHHa Tpe6yeT cneLLHaJlblIOH Hay rioi pa3pa6oTKH.
LlcJlecoo6pa3lio npuMexeHHe HPH 9YMC HJIOTOflJIHbIX H HeCHOKa?
HOCKOJ1bKy OH y,-?y'ILHaCT (j)yHKRHOHaJIbHoe COCT01HHe ueHTpaJIbHOFI
HepBHOH CHCTCMbI H 6aKTepwUHAeH B OTHOLIICHHH MHOFHX MHKpo6OB,
OCJ1O}KHHIOIU1IX Te4ICHHC '-IyMbl FIJI 0TW11 F1b1X. OAHaKO mexaHH3M Aeli
CTBI151 'leCHOKa AO CHX flop euie FIeH3BeCTeH.
.TIe'leolie HepBHbIX npOHBJIeHHfi '-IyMbl IIJIOTOAJ(HbIX nyTeM oxpa--
FIHTeJIbHOrO TOpMO}KeHHfl CHOM, B ero pa3JIHTIfibIX BapHaHTax, OCHO-
BaHO Ha Y'leHHH F1aBJIOBa, pacCMaTpHBafolgcro COB KaK OXpaHHTeJIb-
Hblli, 3aLUFITHbIH IIepBFIblcl MexaHH3M, peryJlHpyloluHH pa60Ty
HCPBHbIX KJICTOK H IIPeAOXPaH5IIOwHI1 HX OT Ope3MePHOFO HCTOI jeHHfl.
ITo I-IaBJIOBy, oxDaHLITeJIbHOe TopMO}KeHHe HBJIfleTCH BbIpa6OTaHHbIM
B npol.tecce 3BOJ110[ulH MCXaHH3MOM (JH3HOJIoFH'-IeCKOIi 3aLwHTbI npo-
THB 6OJIe3HHeTBOpHblX BJIHSIHHcI, Bbl3bIBaeMbIM B KOpe 6OJIbLHHX HOJly--
LHapHli FOJIOBHOFO MO3ra. A. F. HBaHOB-CMOJIeHCKHI1 yKa3aJI, 1IT0
HaHJIy'-ILHHC pe3)'JlbTaTbI JjaeT KOM6HHHpOBaHHOe CHHTeTHLICCKOe-
JIe'IeHHe, B03,gefCTBylOLLl,ee KaK Ha 3THOJIOrHTIeCKHFI (IJaKTOp? TaK H
Ha MO6HJIH3aUHIO OXpaHHTeJIbHOFO TopMO}KeHHH. Hcxo1UT H3 3TO170,
ueJ1ecOO6pa3HO 3KCIIepHMeHTaJIbHO yCTaHOBHTb BO3MO}KHOCTb J OHOJI-
HHTb CXCMy COHHOH TepanHH '-IyMbI BJIOTOHJ(HbIX, pa3pa6OTaHHyfo
A. A. q)aAAeeBbIM H B. M. UaHHJIeBCKHM (1953), BBeJjeHHeM Hap3H-
TCPaJIbHO CHCUH(IHOCCKOIi CbIBOPOTKH HJIH BaKUHHbl.
Y co6ax Bo36yaHMOFO THHa HepeJ(o3HPOBKa CHOTBOpHbIX BejjeT
K ne,peHanpfl}KeHHfo TOPMO3HOF0 npouecca H K TOKCH'-IeCKHM npO5lB-
JIeIIH2M, a I1pH HC,L )CTaTOgHOCTH a03bl BO3HHKaIOT HBJIeHHH 39CJOpHH
1-1 aPYFOFO CHJIbHOFO B036y}KAeFlHH. F103TOMy Hy]KHO HHAHBHayaJIbHO
noa6HpaTb OHTFIMaJIbHble J1.O3bl CHOTBOpHbIX npenapaTOB JjJlfl CO6aK
C Pa3JIH4HbIM11 THnaMH HepBHOii CHCTeMbl.
PallHOHaJlbilao CBoeBpeMeHHafl H HHAHBHAyaJIH3HpOBaiIHaH CHMn-
TOMaTH'ICCKaH TepanHH '-IyMbI HJIOTOHJ(HbIX, OCO6eHHO B ee OCJIOrKHeH-
lIbIX (popMaX, TaK}KC HMeCT Ba}KHOe 311ave1-HHe. OHa CHOCOCCTByCT
opraHH3My CnpaBHTbCH C HH(1)eKuHOHHbIM Ha'-Ia.moM H BPHBOJjHT
K 6JlaronpHflTHOMy HCXOAy 6oJIe3HH. TaK, npH 0'-IeHb BbICOKOIi TeM-
IlepaType F1OKa3aHbI }KaponoFIHN(aloLuwe, npIi fopa}KeHHH JlerKHx H
ocJla6JleHHli CCPACOHOH Ae9TeJlbHOCTH - cepJje'-IHble H B036yMcL alo-
IuHe npenapaTbl, I1pHCTHHIZeBCKHe yKyTbIBaHHH H KoMnpeccbl Ha 06-
JlaCTb rpyiUloli KJIeTKH L p.; npH nopa}KeI1H51X }KeJ1ygKa H KHIIIC'-IHH-
Ka - Ae3HH(j)mIHpyiomHe, CJIa6HTeJIbHble H BA}KyLuHe cpeACTBa, a
npH HB,-eHIl X Bo36yaKaeHHa H CyAOpOraX - XOJIOAHaa BOJja Ha CHH-
Hy H Ha 3aTbIJIOK, FIOKOH, COJjep}KaHHe B TeMHOTe H HapKOTHKH.
B CBeTe H3JIO}KeHHOFO HeJIb35I COFJIaCHTbCI C AOFHHOBbIM, '-ITC
3THOJIOFHH, mexaHH3M H naTOreHeTH4eCKHe CpaKTOPbI npH uyMe njio-
TOflJ(HbIX BbIABHraIOT Me;pOnpHHTHH, HaHpaBJIeHHble npellMyLuecTBeH-
110 Ha HoRaBJIeHHe BTOPH'-IHOii HHCpeKUH-I. UeJlecoO6pa3HO OAHOBpe- -
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
McHHoe npHMeneHHe CneuHC4H4ecKoro allTHBHpyCHoro (cepoTepanen
Tngecxoro, BaKUHHOTepaneBTH4ecxoro) xHMHOTepaneBTH4ecxoro H
CHMHTOMaTH4eCKOrO JIC4eHH51 Ha BceM npOTIDKeHHH 4yMHOI1 HHCpeK-
UHH. JIe4aH[HII Bpa4 HIHpOKO J[OJI}KeH HCIIOJIb30BaTb OrpOMHbI13 apce-
HaJI CpapMaKOJIorH4eCKHX cpeJCTB, coo6pa3y5lcb C oco6eHHOCTHMH
Ka}K4oFi 6oJIbHOIi C06aKH, JIHCHubI n lip. Ha HaIH B3FJ15IJ[, BecbMa
ueJIecoo61pa3HO HiHpOKoe OnbITHOe npHMCHCHHe HeKOTOpbIX npenapa-
TOB (rJIIOTaMHHOBaH KHCJIOTa, HopJIeI3uHH, HaraHOJIb, aKpHaHH),
KOTOpble B HaIHHX 3KCnepHMCHTaX U0J[aBJIHIOT pa3MHO}KeHHe BHpyca
4yMbI fJIOTOHJ[HbIX B PK9.
HaHIH Ha6JIroueHHH, HaKOHeu, nOKa3bIBaIOT, 4T0 6JIarOnpHHTHble
yCJIOBHH BHe1UHeI3 cpe,ubl - xopouiHe yCJIOBHH coaep)KaHH5 H yxo,aa
H nOJIHOueHHOe nHTaHHe - aKTHBHO CH0006CTByIOT 60JIee 6bICTpOMy
H HOJIHOMY BbI3AOPOBJIeHHIO 60JIbHbIX ?KHBOTHbIX. JIeqeHHe 4yMb1
y co6aK, JIHCHu, HOPOK H apyrHx nJIOTOSILHbIX JIHIIIb TOrJ[a MWKeT
6bITb BHOJIHe ycneUlHbIM, eCJIH B KOpMOBOii pauHOH 6yaeT BBCaeHO
J[OCTaTO4HOe KOJIH4eCTBO 6eJIKOB, BHTaMHHOB H apyrHX JIerKO ycBaH-
BaeMbIX H nHTaTeJIbHbIX KOPMOB (5H3ua, csexcee MHCO, MHCHOH
6yJIbOH, xiie6, MOJIOKO, BHTaMHH Bi H zp.).
HeT n04TH HH OaHOFI rpynnbi XHMH4eCKHX cpenCTB, Te HJIH HHbie
npeaCTaBHTeJIH KOTOPOH He 6bIJIH ON HCnbITaHbI H He peKOMeHaOBa-
JiHCb 6bI J[JIH JIegeHHSI 4yMbI nJIOTO$IJiHbIX.
B J[aHHbIFI pa3JIe.I crpynnnpoBanbl npenapaTbT, KOTOpble no HX
HanpaBJIeHHOCTH H B03MO}KHOMy McXaHH3My aeHCTBHH 6oliee Bcera
mpeanOJlaraimCh KaK XHMHOTepaneBTH4eCKHe,
IlpenapaTbl HoJ[a
H3 npenapaTOB Hojja Han6oJIbinee npHMenenne HaxoJ[HJIH uTpud
(0,1-0,2% nOJIKO}KHO HJIH BHyTpHMbIHIe4HO), a TaK}Ke erO 3aMeHH
TeJIb 1CaUO3OJl - 1-12 MJI BHYTPHBeHHO HJIH 5-30 MJI fOaKO)KHO.
XopoiuHe pe3YJlbTaTbI HpH HeDBHbIX HBJIeHHHX aaeT 10% U0d8a-
soeeK npH BTHpaHHH Ha Ho4b B o6JIaCTb HOSICHHubI.
IlpenapaTbl cepe6pa
9TH npenapaTbl ycneLIIHo npHMeHAIOTCSi npH HBJIeHH51X CO CTOpOHbr
SKeJIyJIO4HO-KHIHe4HorO TpaKTa: I % uXTapaaH, 1 % npOTapeo1I -
nepopa.nbHO B JI03e OT 7 ao 12 MJI, I % KOJIJlapaOJ - 25 MJI BHyTpH-
BeHHO HJIH BHyTpHMbnHIe4HO. IIpH 543BeHHbIX KepaTHTaX Ha3HagaeTCN
0,1-1% a30THOKUCAoe cepe6po-3,5 KaneJIb B rim c noc.neayKUunM
TIPOMbIBaHHeM I % XAOpUCTb6M HaTpOAt. A3OTHOKHCJIOe Cepe6po B BHae
KJIH3M peKOMeHJiyeTCH npH 4YMHbIX nOHocax C KPOBbIO.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IlpenapaTbl BHCMyTa
143 npenapaTOB BHCMyTa npH HepBHbIX npOSIBJIeHHSIX y CO6aK (THK,
wyAoporH, nape3bl H Ap.), a TaK}Ke HpH nOHocax xopoLLiHe pe3yJlbTaTbl
Aaer BHyTPHBeHHoe BBeAeHHe KoJlnoudaAbNo.o BUCMIyTa B A03ax
1,5-3 r (npOTHB0nOKa3ano co6aKaM C HepBHOI3 KOHCTHTyI),HeH),
BHyTpHMbIHIcLIHOe BBeAeHHe 6uoxuHoJZR (COAep3KnT 20% BHCMyTa,
31 % XHHHHa H 49% noAa) B A03aX 0.05 r Ha 1 Kr }KHBOFO Beca.
Jl. A. cDa,IjAeeB (1950) peKOMeHAyeT KYPC H3 10 BHyTpHMbILHe'IHbIX
HH-beKuHll 6nOXHHOJI5I no 1 MJI (Hociie neHHUHJIJIHHOTepaHHH).
Kcepo4wp,II B Ao3ax 0,1-1,5 r Ha npHeM (B 6oJllocax c caxapoM)
3(p(peKTHBeH npH TH KeJIbIX nonocaX H BAyBaHHHX B nOJIOCTb Hoca npH
,o6HJIbHbIX pHHHTaX.
(Pap6onpenapaTbl
Px,a aBTOpoB coo6luHJIH o6 3(p(peKTHBHOCTH JlelIeHHH HeKOTOpbIMH
cpap6onpenaparaMH: Tpunau6Jty-BHyTpHBeHHo no 0,03-0,04 r Ha
1 Kr }KHBOro Beca H uaeauOJzolvt - BHyTPHBeHHO B )1o3e 1 r.
113 aKpud uioeblx npOH3BOAHbIX pexOMeHJiyeTCx aKpucbilaeun -
B JI03ax 0,25-1 r nepopaJlbHO H Tpunac/Jizaeuu -- no 0,2-0,5 r
2 pa3a B AeHb.
IlpenapaTbl xaopa
M. K. RaJIMaTOB (1927), A. 1-1. COIIIeCTBeHCKHI%I (1928) pexoMeH-
AyIOT napbl x iopa npn KaTapaJlbxblx npoueccaX B BePXHHX RbixaTeJIb-
HbIX nyTHX.
cOpMa.nbAerHA H ero npenapaTbl
VpOTpOnun 3(p(peKTIIBeH HPH e}KeJ1HeBHOM, B TeLIeHHe 10 AHea,
IHIITpaBCII03HOM HJIH HOAKO>KHOM BBeJI.CHHH 1-2 r npenapaTa B
5-10 MJI (pn3110JI0rHTICCKOr0 pacTBOpa nlpu napaJIHLIax, IlapanJlernn,
xopee H APYTIIX IICPBIIbIX ABJIeHHSIX LIyMbI nJIOTOflrHbIX. PeKoMeHAyeT-
CH TaK)KC KOM6HIIHpOBanooOe JIe4ICHHe ypoTponnHOM 11 CyJ7bcj7apceno-
iioJLt (Bait IloncpHHre, 1931) H BHyTPHBeIIHOC BJIHBaHHe 2-3 MJI
40% ypoTponnna 0) H0BPCMel1II0 C Tepanuei neIiur4u.Muuo,x, 6uoxu-
koJiem u ?JI1OKO30u (J1. A. (DaAAeeB, 1950).
IlpenapaTbl (penoJla
H3 npenapaTOB q)enoJia caAoJI pexoMeHAOBaH B. B. Konre (1940)
I(JIS1 )je3HH(1CKLi,HH KHLHe9HnKa, OAHaKO, no H. F. 3anaAHIOKy (1946),
On He3(p(peKTHBeH. Ilapbl KpeoJluna nOKa3aHbI IIpH cep031ibIX H rHOft-
HbIX KOH'bIOHKTHBHTaX H pHHHTaX.
KHCJIOPOA H Beu&ecTBa, ero OTAaIoLuHe
TepanHS1 KHCOOpOAOM OT 0,3-1,3 JI ao 5-8 >I nOAKO)KH0 AaeT
IIpoTHBopetlHBble pe3yJlbTaTbl. MapeaHi4eaorcucIblu Kaizuu (1 : 5000)
pCKOMCHAOBan aJIH ae3HH(peKUHH npH vyMe HJIOTOSIAHbIX.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
(DHTOHL(HAbi
143 (1)HTOHLUH)A00 teCHOK peKOMeHAOBaJIH M. JIyKHH (1848), KIli
(1928). Ho Al. H. AHTOHOBy H 10. B. BaBHJIb1tIeBy (1952) noJIe3HO
3-10 pa3 HHTpaBeH03HO BBOAHTb 5--1O% !paCTBOP ~ieCHOgHOrO COKa.
npenapaTbi MblinbcKa
Hpii tiyme co6aK peKOMeH,nOBaHbI MHOrHe pa3JIII4Hble MbILHbflK))-
BHCTble npenapaTbI. HaH60JIbwei 0OHyJI51pHOCTbIO 1!0,TIb3yIOTCf! ClyJib-
tpapceHOJI B Bo3pacTalOlu1x A03ax (0,06-0,7 r) AJIfl IlegeHHfi nocJle-
9yMTIbIX napaJIHVeH H ApylHX HepBIibIX HBJIeHHH, HO8oapCeHO6e113OJl-
HHTpaBe1103HO B A03e 0,01 r Ha 1 Kr npH HepBHbIX H TIerOtgHbIX HBJie-
HHHX.
Cy,nb4)aHHJIaMHAbI
H. CyJlb(4aHHJIaMHAOB CTpenT0l4ll(9 KpaCHbl17 6bIJI IlepBb1M IIpCn!!-
paTOM H3 3TO}I rpynnbl, ycneuiHO HpHMeHeHHbIM HpH 6aKTepHaJIbHbIX
OCJIO}KHeHHHX tlyMMbl y co6aK (14. E. KopHMaH, 1937).
XopoluFe pe3yJlbTaTbl B Haga.ne 3a6oJIeBaHHfi AaeT IIpHMeHeHTIe
no 0,3-0,5 r cTpenrOl4uraa 3--4 pa3a B AeHb H B TeLlemie CLII,e 5 AH:ii
noc.ne CHHN{eHHH TeMnepaTypbl JO HOPMbI H BHAHMOIO yJlytlnleHHSt
COCT05THHH (B. FoJIy6KOB, 1939, JI. B. [lapaluyK, 1939, B. (D. AAar ::!-
HOC, 1950).
XopowHe pe3yJlbTaTbl noJLyvaIOTCH npH Aatle 6en.oeo cTpenTOt 11() i
3 pa3a B aeHb no 0,3 r Ha npneM (K. H. T(MInTpHeB, 1942), 4 pa3,i ,!;
Aexb no 0,5-1,0 r (Jlec)iuTa. T, 1942) HJIH 3 pa3a B AeHh no 1,0 r
BMecTe c ypOTpOfHHOM (A. B. HJIaTOHOB n C. A. H,nbHIICKni, 1942).
CyAb(4ul uH 3(4(.4eKTHBeH npH ;Lame tlepe3 POT H oAHoBpeMe.HTTI)
noaKO}KHO (Mapiyc H apyrme, 1938). Ho F pHany (1938), KHTOBY
(1949), 3q)(1JeKTHBHOCTb cyJIb(JH)jHHa HOBbinlaeTC 1 HpH oAHOBpeM(!I-
HOM BBeaeHHH rHnepHMMyHHOH CbIBOpOTKH.
KapnHH H A6paMOB (1950) B TetieHHe 5 AxeH H3JIe4ii.ni CyJIb(~H-
J1sHHOM 10 H3 14 60JIbHbIX IIyMOH co6aK, AaBaH CYJIb(JHAHH tiepe3
Ka]Kable 3 Baca; CyTOI]Hafi A03a COCTaBH.na 5,5 r. OAHOBpeMel-Ili()
BBOAHJIaCb CbIBOpOTKa.
B. (D. AAaMaHHC (1950) peKOMeHAyeT CyJIb(~HalH 6 pa3 B CyT!:I1
no 0,4 r H O)jHOBpeMeHHO CTpenTOILHA H neHHUI4JIJIHH. , . )J. JIOrnHOH
(1950) nOKa3aJI, IITO OCJIO1KHeHnH IIyMbI y co6aK, o6yCJIOBJIeHH!,I('
BTOpH4IHOH MHKPO(IJJIOPOH, ycneuiHO H3JIegHBaIOTCH CyJIb(4HAHHOM nP)t
ero co)iepx{aHHH B KPOBH 3-4 Mr%. Y co6aK c HJIOXHM anneTHTOM II
6e3 ]Ka)Kabi 3Ta KOHLI,eHTpauHS! CyJIb(JHAHHa CO3AaeTC51 AatleA B BHae
paCTBopa HaTpHeBOB COJIH HJLH B pacTBOpe c rJI1OKO30H nepopaJlblIO,
Ka3KAble 5 gaCOB, 143 pactieTa CyTOHHOB A03bI 0,14-0,2 r Ha 1 Kr Beet
co6aKH. Hpe}KAeBpeMeHHOe npeKipauieHHe CyJIb(4H.i[HHOTepanHH, AaA{e
y co6aK C HOPMaJIbHOB TeMnepaTypOB, BeAeT K peUHAHBaM. r1oc.nea-
HHe nAIOXO HJIH cOBCem He no)Aa1OTCH CyJIb(HAHHOTepanHH H3-3a
no5IBJIeHH3I CyJib(4HAHHOYCTOi1tIHBbIX pac 6aKTepHB.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OTpHUaTe.ilblibie jlaHHble o ripHMeHeHHH CYJIb(JHAHHa COjlep}KaTCSi
B coo6Luenuux Ferlrepa H Uperepa (1944) H ApyrHx aBTopoB. TaK,
110 CTpaTTepy (1949), YJIbpHXy (1950) H aPYFHM, CyJIb(4HaHH TOKCH-
'TeH, MaJiO 3(jq)eKTHBeII H IIpOTHBOnOKa3aH npH HCPBHbIX ABJIeHIIHX,
KOTOpbIC Oil o60CTP5IeT.
JIUCIJJlb(/)aHl U N,OpCy.4b(/U3OJl peKOMeHJI,yIOTCR MHOI-HMH aBTOpaMH
Wpa() it Ap?), oco6eHHO npH nopa}KeHHnx KHIHC4HHKa H COBMeCTHO C
cr,IBOpOTO lHbI I .,ic'icUI1e1V1 (KHTOB, UJIaTOHOB 14 HJIbHHCKHA).
HJ110CHHII y Cnen1110 npuMennJI JulCyJIbcpaH npH }KeJ1yj o4HO-KHLHe4-
IILIX paccTpouCTBax'IyMHoro nponcxo}KAeHHH, a JIJIH npej[ynpe}KAeHHH
ocJIO}KHEHHA CO CTOPOHbI JIerKHX--HHTpaMyCKYJIH 1IO CyJIbC~HJ>,HH no
0,3-3 pa3a B uenb.
Anb6ytfud (napaa,uutiocaJeur uJtoeaR KUCJOTa, HACK) pexoMeH-
AOBaH HHMaHAOM (1942, 1944) H oCO6eHHO 3Cp4peKTHBeii npH HyMHbIX
1IHCTIlTBX (CTpaTTep).
Hociie,ailee B,peM51 B CILIA ycneLUHO HPHMCHAeTCH BHyTpHBeHHOe
BBep,CIIHe npenapam SRH (uaTpu(icyJlb opu14unaudpa3url) B a03ax
100 Mr Tia 2---2,5 Kr Beca; BBOAHTCH McAJIeHHO, He 6OJiee I MJI B
5 ceK. (HJlyrep, 1954).
143 a1ITH611OTHKOB - neHUt1UJiAUH, HBJISISICb HHepTHbIM B oTHol:He-
iuiu BHpyca 4VMbI IIJlOTOrwIIbIX, BbICOK03rx1JeKTHBeH j1.JISI TiegeHHH HPH
()CJiO}K1ICIiIIIIX IiVMbi COHYTCTBYIOHI.HMH HHCpeKLIHSIMH 6aKTepHliHoro
nponcxoMCA.eHHH.
MHKyAa H XOTT (1947) HYTeM 1-22 HHTpaCHHHaJIbHbIX HH'beK-
rwu (100--200 7bic. ME B I MJI 4)H3paCTBopa) H3JIe4HJi 4 H3 7 iyM-
IIbIX co6ai,. C SHR.;V HHHMH MelIHHI-HTa. KaTeropH4eCKH 13o3pa?KaeT HpO-
I'HB IHHT'paJII0M6aJIbHb1X HH-bCKIIHA IIeHHLIHJIJIHHa Y.IIbpHX, yKa3bIBaB,
'ITO OHH Bb13bIf3aIOT CHJIb1Iy1O H 06bi4H0 CMCpTeJlbHYK) HHTOKCHKaLIHIO.
HepCneKTHBeH I1pi 4yMHbIX McHHHIHTaX KpIICTaJ1JIH4eCKHA 6eH-
3UJl - nekutftMJlun, npeAJloxKelulbiA 3. B. EpMOJlbeBoi (1953). OH
51BJ15IeTC11 eAHHCTBeHIIbIM nperapaTOM, KOTOpbIA MO}KHO BBOAIiTb
71cnOCPeJICTBCHHO B CIIHH11OMO3FOBOA KaHaJI.
KHpi (1947) n:Lje4H.II 2 4YMHbIX co6aK 3-6 HOAKO)KHbIMH
IIHI.eKII IHMH 110 33 TbIC. ME neuuuuJ4JIHHa iiepe3 KaiKjjble 3 4aca.
A. B. CITHC13 c coTpyjlliHKaMH (1948) ycneLHHO Jle'IHJI '-IyMHbIX CO6aK
I:HVTpnMbIHIe4HbIMII HHbCKUHHMH 25 TbIC. ME B 20 MJI (kH3paCTBOpa
'lepe3 Ka)KJjble 3 4aCa. O61Aee KOJIH4eCTBO BBeJ eHHOI'O HCHHIIHJIJIHHa
KOJie6aJIOCb OT 150 . o 300 TbIC, ME. HH ojlHa H3 7 co6aK C Bbl,paJKeH-
ITbIMH HepBHhIMH HBJIeHH11MI4 He BbI3,aOPOBeJIa.
Ho JIy'CTHr-JIeHaBa (1949) neHHI1,HJiJIHH 3(p(~eKTHBeH y 'IYMHb1X
co6a'K C. FilOciHbIMH HpolleccaMH.
JT i JIegeHHSI 3iI1J,e4)aJIliTOB gYMHOIO npoucxo iieHHA caJ1,j[eeB
pa3paa6o.ra.iI eJie4yrOIuyio McT0,IIIKy: IIeHHLIHJIJIHH-2 Mum. ME (4epe3
Ka3Kjlbie 4',gaca no 100-150 TbIC. ME BHyTpHMbIIIIe4I1o) H OjIHO-
BpeMCHHO e>KeAHeBHO. BIR'Tp.HBeHHHO. 40% r.rlioKOIN (AO 30 MI),
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
40% ypOTpollnxa (2-3 MJI) H 6HOXHHOJIH (1-1,5 MJI), a Taxxce
BHTaMHHOB JWISi peryJIHpOB HHH pa6OTbI cepuua H KHIneLIHHKa. rlpH
OTCyTCTBHH 6HOXHHOJI5I-O,1-1 MJI 10% ipaCTBOpa HOAHCTOrO HaTpa
BHyTpHBeHHO.
AAaMaHHC peKOMeHAyeT HH-beKLHH neHHWHJIJIHHa (500 TbIC. ME
B 20 MJI (JH3paCTBopa) BHyTpHMbIIIIe1HO no 1-2 MJI LIepe3 Ka>K,ble
3-4 qaca, B Te'IeHHe 2-3 CyTOK, H OAHOBpeMeHHO jay CyJib(1HAHHa
H CTpenTOuHAa?
fIeHHuHJIJIHH, corjiacno I1Acy (1951), 3(Jcj)eKTHBeH HpOTHB BTOpHLI-
HbIX B036yAHTeJIeM, OCJIO}KHHK)MUIX uyMy y Co6aK, B AO3aX 2,5-4 TbIC.
ME Ha 1 Kr Beca 4-6 pa3 B AeHb. XopoiuHe pe3yJlbTaTbI IIpH rHOI3-
HbIX KOH'bIOHKTHBHTaX H pHHHTaX tIyMHOI'O npOHCXO}KJjeHHSI AaeT
KaJIb4ueeo-neHUtfuiziluKO6aA Atia3b, co. ep}Kaluax 14,3 TbIC. ME B 1 r
(Fcnur n Jipyrue. 1952).
rlpH JIewHHH KHIIIeLIHbIX npOHBJIeHHcI y IIyMHbIX co6aK nOJIyLIeHbI
XopouJHe pe3yJIbTaTbl nyTeM HH-beKuHH Llepe3 12-24 Llaca no 100 TbiC.
ME neHHuHJIJIHHa B 5-8 MJI HopMaJIbHOA CbIBOpOTKH (B. M. He'CTe-
penxO, 1953).
Flo AaHHbIM HJIIOCHHHa, JIegeHHe LIyMHbIX co6aK neHHuHJIJIHHOM
H aHCyJIb(IJaHOM Majio 9(j c4 eKTIIBHO. XOpOHIne pe3YJlbTaTbI B I-Ia4aJIb-
HOCI CTaAFH AaeT neHnuHJIJIHH B cOeJ!HHeHPH C HecneLH(bHLIeCKOI(
cepOTepanueM. ABTOp peKOMeHAyeT nellHuIJIJIHH Ha npOTHBocn6Hpe-
5I3BeHHOII CbIBOpOTKC - BHyTpHMbIineLIHO 2-3 pa3a B JreHb no 50
TbiC. ME, a Liepe3 12 ,lac.-no 100-150 TbIC. ME.
BU8UgUJlJlUIL - npenapaT neHHuHJIJlnxa, 34x1 eKTuBeH B Ha,IaJlb-
HbIX CTaAHHX 6OJIe3HH (MeJIbC, 1948) H npOTHB
(JIyCTBHr-JIeHABa, 1948).
JJeJIecoo6pa3HO npHMeHHTb npn LIyMe y HJIOTOIIAHbIX nojiygeHHbie
3. B. EpMOJIbeBOi3 C COTpyjjH!IKaMH HOBble JleKapCTBeHHble (JOpMbI
neHHuHJIJIHHa: 9ICAaO1-GO80l.IUJl/IUK aJIHTeJIbHO (24-48 nac) coxpaH51-
IOMHNC51 B opraun3Me. flpenapaT AOCTaTOIIHO BBeCTH 1 pa3 B CYTKI1
npH nHeBMOHnH, 3Hue()aJIHTe H ApyFHX OCJIO}KHeHnHX LIyMbi, a TaK}Ke
FloaotlullJCUH.
IIITaynan - npenapaT H3 MyTHpOBaHHOFO nJlecneBOro rpu6Ka.
Ho f e1 HpHXy H KyHue (1949), niTaynaH 3(11)(kCKTHBeH B 85%, a B 3a-
Hy1ueHHbIX CJIygaSix 6o.Ie3HH - B 50%; OH He4(JeKTHBeH npH HepB-
HOII KJIUHHKe ,IyMbi.
Kypc JIeLIeHHSI COCTOHT H3 3-4 HH-beKu1n1, Bb13bIBaIOHuHX Jjenpec-
CHIO, LITO HBJISIeTCSI nOKa3aTeJieM HOJIO}KHTeJIbHOI3 peaKwHn; eCJIH
jienpeccu en e He naCTynuJla, npenapaT AOJI}KeH BBOAHTbCSI BHOBb
B yBeJIH,IeHHOII A03e. HO MHei[nIO aBTOpOB, InTaynaH, Cneuu(1MI ieCKH
Ae1 CTBy1OIuHii Ha BnpyC LIyMbI, H neHnnHJIJIHH, jjeIACTByIOLUHI3 Ha MHK-
po(JJiopy, 5IBJIOIOTC51 3(4cpeKTHBHOR Tepannel3 LIyMbI.
CTpenTOA2ut un. Flo 1IIH,nAcy (1951), off B(p(peKTHBeH npH 3a6o.ne-
BaHnn co6aK LIyMocI, OCJIO}KHeHHOI3 rpaMM-OTpHuaTeJIbHOII MHKpO(pJIO-
pOH HJIH YCTOI1LIHBOfi K neHnUHJIJIHHy rpaMM-noJlo}KHTeJIbHOii MHKpO-
(PJIOpOII. CTpenTOMHLHH 3(h( eKTHBCH, eCJin erO KOHueHTpa[HH B KpOBH
COCTaBJISieT He McHee 3-6 ME/Kr. flpenapaT BBOA1TC5I BHyTpHMbI-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HIeIIHO, TaK KaK H3 }KeJIyROIIHO-KHHIeIIHOrO TpaKTa OH He BcaCbl-
BaeTC51.
XJIopMut4eTUk (xJzopaniienuKOJz). 11o aaHHbIM KopjI,H H JjpyrHX
(1951), XJIOPMHIjeTHH 9(p(peKTHBCH npH IIyMe y cO6aK. BBOJ ITCR
HO,IZKO}KHO B J O3aX B CpeJHeM 80 Mr/Kr Ha 3 HH"beKUHH B TeIIeHHe
CyTOK. 1'13 4 JlelleHHbIX XJIOpMHIjeTHHOM cO6aK Bce BbI3Jj0POBeJIH,
a 4 KOHTPOJIbHbIX C06aKH najr.
CUHTOMUt4Un (COBeTCKHfl CHHTeTHIIeCKHcI XJIOpMHUeTHH), no Ha6-
JI1OJ[eHH5IM A. E. EaKHIH (1953), BeCbMa 3(p(peKTHBeH HpH nopa}Ke-
HnHX KIIIIIe'IHHKa y co6aK B Jj03aX 0,02 r/Kr Beca HjeHKOB, 0,2-0,4 r
RJIR B3POCJIbIX co6aK B TCIIeIIHe 7-10 gHeii.
Teppa=t4un B Jla6opaTOpHbIX yCJIOBHHX, corJlaCHO JjaHHbIM
1IIHJIJjca, o6JlaJjaeT BHpyJIHU,11AHbIM AeIICTBHCM B OTHOHIeHHH HeKOTO-
PbIX BHpYCOB, B 4acTHOCTH BHpyca ITyMbI UJIOTOSIJI,HbIX. Flo JjaHHbIM
AHTeJIHyca (1951), , Iy'ri a (1951), TeppaMHljnH 3(p(peKTHBeH (HHTpa-
BeHO3HO H nepopaJlbHO) npH KHHIeIIIIbIX HBJIeHHHX T-IyMbI y co6aK
BMeCTe C CbIBOpOTKOI3 H HpH nHeBMOHHH, IIO He JehCTByeT npH 3HIje-
(paJIHTHIIeCKHX SIBJIeHHSIX.
Aypeomul4uH. D(p(peKTHBeH gJIH JICIIeHHH TOH3HJIJIHTOB, IIyMHbIX
npOIjeCCOB B BCPXHHX RbIXaTeJlbHbIX nyTSIX, npH nHeBMOHIlHX, racTpo-
3HTepHTaX H RpyrHX OCJIO}KHeHHHX IiyMbl BJIOTOHJI;HbIX. BBOJUITCH
HOJjKO}KHO 4 pa3a Ka3KJjble 5 IlacoB (HO 10 Mr/Kr). Flo IaHHbIM
AJIbTMaHIa (1951), Bce TIeIIHBLIImec5i co6axn (6) BbI3,jOpoBCJIH, a Bce
KOHTpOJIbHble (4) norn6JiH. J>Koyna H upyrHe (1952) coo6HjnjIH,
IITO aypeOMHUHHOM, aaBaeMbIM B KanCy.iax 3 pa3a B CyTKH B KOJIH-
IICCTBe 80-124 MI', H3JICIIeHO OT ITyMbI 35 co6aK 143 60. AIIaJIOrnIIno
JIecCTByeT 6uoA1ul4uN - COBCTCKHII CHHTeTH9eCKH1'I aypeoMnuuN.
CPERCTBA, TOPM03$IHAHE RESITEJIbHOCTb UEHTPAJIbHON
HEPBHOH CHCTEMbI
npenapaTbl 6ap6OHTypOBON KHCJIOTbI, MOp(pHN
H j[pyrHe HaPKOTH'CCKHe BeU[eCTBa H 6pOMHpb1
DTH npenapaTbI IIOKa3aHbI HpH OCTpbIX HepBHbIX HBJIeHHHX
ITyMbI HJIOTOHJjHbIX (CyjjOpOrH, 9nIIJIerTH(JOpMHble npHna,KH H ap?)?
PexoMeHJ yloTCH eepouwJi, cyJtbcbOHaJl, ypeTan, aA iuonaA, npoMU-
naA, ceeeHa.it B Jt03ax 0,08-0,16 r, JZFOAtUHUJl B 103,IX 0,01-0,03 r
Ha 1 Kr Beca (EJIoK, 1916), no 0,1 Ha HOIIb (B. HapcKHII, 1928).
YJIbpHX, IIIy,nbl e peKOMeHJjyIOT B Te'IeHHe He McHee 10 Jjnei
JjaBaTb, B 3aBHCHMOCTH OT IIaCTOTbI HepBHbIX npncTynOB, e?Ke)jHeBHO
no 2-4 Ta6JIeTKH (coaep3KaT no 0,01.5 JIIOMHHa.na),
COIIeTasl HX c 2 HH'beKUHAMH no 0,2-0,8 MJI TaK Ha3bIBaeMOPO
, KOTOpbI1I COAep)KHT HJj rpeMyllel3 3MCH . IIITay6eHpayx (1951) coo6uiHJI, TITO 3MeHHbIII fur. (vipera-
berus toxin) H3JIe'IHBaeT reMO3HTepHTbl IIyMHO13 3THOJIOFIIH.
BpoMudbt naTpu5l, KautuJl H aM.4lonuJZ JjaIOT xopoiiHe pe3yJIbTaTbl
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
npH Ha3HageHHH BMeCTe C eJIIO1CO3OII ((DaAAeeB). XOpouIO AeI3cTByeT
6poMypait (0,05-0,1 MJI Ha I Kr Beca) H keepokaJC (6poM3TUJCate-
Taku(9) no 0,2-0,3 r Ha 1 Kr Beca.
nPEnAPATbI, BO3BY)KAAIOIUHE )I(EATEJIbHOCTb ItEHTPAJIbHOH
HEPBHOH CHCTEMbI
CTpuxKuU n ero npenapaTbl s(p(peKTHBHbI npH nape3ax, napaJlH-
qax H T. A. B A03ax 0,1-0,2 Mr (BMecTe c akTunupunoM).
OAHaxo cIeJIKep (1950) OTMeTHJI, IITo npH napajintlax CTPHXHHH
HHOI'Aa BbI3bIBaeT TSI}KeJIble CyAOPOrH H CMepTb.
FpHTuJIb (1950) PeKOMeHAyeT CTpHXHHH npH napaJintiax MOZIeBOrO
ny3bIP5I B A03e 0,001-0,003 2 AHH noApHA, c nepepbIBOM B I aeHb,
AO Tex nop, nOKa He fOHBHTCH MO4e0TAeJIeHHe.
. IIOA 9THM Ha3BaHHeM H3BeCTeH npenapaT, coAepxca-
nZH}3 B OAHOI-i aMnyJie 0,01 r CTpHXHHHa, 5 MJI rHJ1pOJIH3OBaHHbIX
JIaKTaJIb6yMHHOB H 0,03 r opraHHtieCKOPO COealiHeHHH MbIIHbHKa.
IlpenapaT BBOAHTCH tiepe3 KaM{JIble 2 AHSI H, no 3aKJIIOtIeHHIO YJIbpH-
Xa, >.
CEPJ1vE9HbIE H )KAPOnOHH)KAIOWHE CPEACTBA
113 cepAetiHblX CpeACTB H. THXOHeHKO (1939) 0006eHHO peKOMeH-
AOBaJI KaMqbopkoe Maclw. I43 POrIOHIDK IOIuHX cpeJ[0TB ueJieco-
o6pa3HO npHMeneHHe alTunupuHa, koea.4beuka, anTuc/Je6puka, (/Je-
HalleTUka, acnupuka npH nOBbILHeHHOIi B036yAHMOCTH H BbICOKOIi
TeMnepaType.
BHOI'EHHbIE CTHMYJIRTOPbl, BHTAMHHbI H 3HAOKPHHHbIE
nPEIIAPATbI
MHOrHe 6HoreHHble CTHMYJIHTOpbI 6JIarOTBOPHO AeI'CTByIOT Ha
peryJIHpylowylo (JYHKILHIO geHTpaJIbHOft HepBHOI3 CHCTeMbI, BeAYT
K BOCCTaHOBJIeHHIO y 60JIbHbIX HOpMaJIbHOrO COCTOSIHHH (11. E. Mo3-
rOB, 1952) H riOKa3aHbl npH ZIyMe fJIOTOSIAHbIX.
K HX ZIHCJIy, B ZIaCTHOCTH, OTHOCSITCH MOJZO1CO H ero npenapaTbI:
aOJIRi no 5-10 MJI BHyTpHMbIIHe'IHO, apaoilaICTUu, RTpek-tca3eUH,
JlalcTOcepuk H Ap. (M. fIaBJIOBCKHI3, 1937).
9(14eKTHBHOCTb JIaKTOTepannn o6yCJIOBJIeHa yHHBepcaJlbHbIM
COCTaBOM MOJIOKa (McnpbI, 6eJIKH, yrJIeBOAbI, MHHepaJibHble BerJecT-
Ba, BHTaMHHbf), 611arOTBOpHO AeIiCTByIOILLHM Ha HepBHYIO CHCTeMy',
o6oraLL[alonu-IM 60JIbHOIi OpraHH3M KOMfJIeKCOM (pepMelITOB 6aKTe-
PHUH)IHOrO H allTHTOKcHgeCKOrO xapaKTepa.
OMHa(duk AaeT xopoiuHe pe3yJlbTaTbI TOJIbKO B Ha'Iajie 3a6oJieBa-
HHH H npeaynpe>KaaeT B03HHKHOBCHHe HepBHbIX SIBJIeHHi3 (F. C. ,Lo-
6poBO.nbCxnA, 1938).
110 PyaOJlb(py (1930), OMHaAHH 3(p(peKTHBeH ripe ZIyMe nJi rro531[-
HbIX y JIHCHIZ H He34(peKTHBeH Y HOPOK H eHOTOB.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
AuTU3ypAiun H ApyrHe dpoLCACeebte tlpenapaTbt C neonpeAeJleH-
HbIMl1 pe3yJ1bTaTaMH Il HMCHHJILICb ;1,JI2 Jle'IeIIHT tlyMHbIX co6aK
(M. TpemniOB, 1941, BeppHHrep, 1946, IIIyjiaiH, 1947, m up.).
BHyTpri 1b1Hle'1Hoc 2-3-KpaTlloe BBeJjeltHe 2-5-10 MJI ,vtnconen-
ronHO2O 0!,,A1,0/-1(1 U AIStcn01'1 (3O0bl 9CKOMCHJjyeT H. Barnii (1940).
Hpn ilyMC CHOTOBHRIIhIX Co6aK 01111 He J3.nn IIOJIO}KHTCJIbHbIX pe3yJlb-
TOTOB (14. MHpoJllo60B, 1932).
HO HanlnM Iia6JIIo;jeHnnM it JIIITep3TypllbIM Jja1111bIll4, ($UTa.MUnO-
TepanUSt npH ilyMC FJ1OTOHUIIbIx AaeT xopoinre pe3yJlbTaTbI; peKO-
McIIJIyeTCn tmeanTOiib (Kpalc, 1930), ackcp6unoeai KUCaOTa (~)reH,
1944, FloliTep, 1948), KOMHJICKC euTaniuHa B (BepptHrep, 1946).
O'. JT. MacJiCilnnKOBa (1934) 1jo6HJIaCb Bb13J1,OpOBJICHn/ 60JIbLHHH-
CTBa 'IyMIIbIX CO63K, 13130,12 BM BHTOMHHa A, C H D.
c1)popnnr (1937) nOr:a3aji, 'ITO Co6aKn, HOJIyt1OBIHHC BHTaMn11bI
A, B H D, IIC 3a6oJIeJinI, HeCMOTpI Ha HCKyCCTBeHHOe 3apa>KeHHe n
TCCHb1I-i KOHTaKT C 'IV'MHbI;14H CO6aKaMH.
Ho (DOxT-M0J1.71epy (1942), CKapMJIHBOHIIe Atac/la u3 3epen ntue-
H(1((bl, CO,Yep>Kalllcro BUTU3II1Ft E, yyMellbIllaeT 'IICJIO HCpBHbIX OCJIO}K-
11CH11BII 4yMbl.
J1ecjHlTa,'AT (1942), JIycTHr-JIeJIoBa, BeppHHrep, IIITe13H (1949),
96epT (1950) 11 ,zpyrlle yK33bIB3I0T na 3(j)(peKTHBHOCTb BUTaMtunoa
BI B2 Hpli IIepBHbiX 1IBJ1e11HflX ilyMbl y Co6ax: HlrbeKil,nn 'lepC3 Jl,enb
no 1--2 NOt LnTaNnlla B! H C}KeJ H0BHan uaua ero zlepC3 por n0 6---
9 Mr B r(2 Iwiic (,--8 11C lIJlb. IJITCNH pet 0 1e11jLyeT BBOJjITb no 0,025 r
nnTaNnlla Bl J1Jiu Jle/iennn co6aK, OCJIenLHHX B pe3yJlbTaTe tlyMbi.
beppmirep ConTaeT o623aTeJlbxbiM nap3HTepHaJlbHOe BBeamie
6oJlblibIM >KIIBOT11bIM 6CTaKCIHIa 11 JIauy 611TO1vtUHHblX Ta6AeTOK B-
KQktnAeKCa.
Ho Max HnTaiipy, TpCBany H MOHTI-OMCpn (1948), KopM, 6ora--
TbIGI BIIr3MHH3MH, CHOco6CTBycr n3JleyCHHIO C06aK, 6oJlbI'bix iiyMof.
BIIyTpnMbliHetHlbre HIrbCKLlHH (1-2 MJI 3--4 Jinn no>Lp5A) ne'le-
110ItHO20 3KCTpaKTa. (nepneieort 4)01)T) 3(j)(j)CKTHBHbl JJ,JIIi oe'eHlln
tlyMHbIX Co6aK C HBJICH1IIMH 3Hrje(j?aJIIITa H ((}KCCTKOlI Jlanbl>, 'ITO
O6-bcCIIBCTCn 6OJIb1IIHM cojjep>KaIIHeM B HCM BHTaMHHa B.
H3 3HdOKpl-IHCIX npenapaTOB Xo.1IMaHCKIIX YCHCLIIHO IIpHMeHIiJI
Heltp0211nO(/n3111-t U llepe6pUH B CO'1eTaHHn C adpenoJ1uH0A1.
HpH ~iyme, no Bonepy (1928), CMH3epcy (1930), FIOHTepy
(1948), XopoIHO JICKCTBVIOT 9KCTpaKTbt U3 U4UTO6udHb1x a napau4uTO-
(311d1qbtX aiceAe3. Ho B. B. Konre (1927), TCCTUKyAApnW I o/cu(9KOCTb
KpaBKOBO JjaeT XOpOi1Ine pe3yJIbTaTbI HpH tlyMHbIX napaiwiax.
He3(j)q)eKTHBHhi UncyAllH, ,YceHCKMl t103060C1 eopht0n (BHTHeFI,
1936) IT -OpAtOHbl Hadnouek;luKOe Kopo(3bt (HHn4an), 1944).
CJieJIaHHble 3a py6e>KOM HeOJI.HOKpaTHble HOHbITKH iiegeHHH HepB-
IIbIX 5BJIeHHYI HpH liyMe y co6aK HapKOT1i ieCKHM CHOM, Bh13bIBaeMbIM
6a6HTypaTaMH, He yBeHHaJIHCb ycnexoM (YJlbpnx H Ap?)
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
A. A. cIaAJeeB H B. M. UaHHJIeBCKHr1 (1953) npe,Jlo]KHJIH c ie-
gyloluylo cxeMy JleTieHnx McHHHro-3HuecpaJIHTOB 4yMHoro npOHCXO)K-
J eHvi H CHOW 3-7 AHeFi noj pAJ IIaeTCH JHOMHHaJI HJln JjpyrOe HapKO-
Tn4ecxoe BeluecTBO H OJ1,HOBpeMeHHo rJIlOKO3a H yp0TponHH (e}KeaHeB-
Ho) H 6nOXHHOJIb (4epe3 AeHb), a TaKx{e I3 B noc.neAyloluHe 8-10
AHeFi. IIpH pe3KHX SIBJIeHHSIX B036y>KaeHHSI-OJ.jHOKpaTHO neHTOHaJI.
Ha OXOTCKOM no6epel{be Jjui i JIeueHHSI TIyMbI y co6aK npI3MeHHeT-
C5I KpOBOnyc!{aHlle: 6oJIblIbIM co6aKaM o6py6aloT XBOCTbI, o6pe3a-
IOT ynln li T. A. (13yulyeB, 1928). KpOBOnycxaiiHe KaK iiapojuioe Cpe,i-
CTBO OTMCTIIJI H BHuHrMan (1935). IIpH cyJjopo)KHblx gBJIeHH51X He-
60JIbIIIHe KpOBOnyCKaHHSI peKOMeHJYIOT T3JI (1939), 1'paTvJlb (1950)
H Jp. Flo T3JIy, noc,ne KpOBO[IYCKaHHH 50 MJI ueJlecoo6pa3HO BHyTpH-
BeHIIOe BBeJenne rOMOJIOrHIIHOu HMMYHHOFI CbIBOpOTKU.
YCI]ewHyIO HOHbITKy JIC4CHH9 IIyMHbIX MHCJIIITOB H 3Ilue4~aJIHTOB
HCKYCCTBeHHO Bbl3BMIHOFl BbICOKOI' TeMnepaTypOu CJCJ]aJIH HaHHCC3,
Bepxce H Kapnax (1928), 3apawa5i co6aK MaJislpneFi. Tpcrep H Jpy-
rne (1949), HH-beuHpOBaBIIIHC nnpucpep H Ipe6pilcjJep. HanpOTHB, no
YJlbpnxy, IIIyJIbue, OHO 6e3ycnelliHO, Ja3Ke npHHOCHT BpeJj.
Ilpn HePBHbIX SIBJIeHHxx: nape3ax, napaJ]H4ax, noj eprvBaHHSIX
pexOMeIIJyIOTCH CpapawH3aujcl H BOJIIble BaHHbI; TOKIT BbICOKOFI 'la-
CTOTbI, AHaTeJMHST, COJIJIIOKC, KBapueBOC o6JIy4ewHe H Jjp. (B. CMHp-
HOB, 1882, H. H. Borj aHOB, 1911, IIeppn H MHJIbJTOH, 1927, KoHre,
1927, A. H. AJIeKceeB, 1930, Jl. Aypmi, 1933, IIIyJIbue H Jp.).
IIpH 4yMe n,nOTOSU HbIX npHMeHSIJIHCb eeTepoeeunbte eunepuv-
lllykhble Cb18OpOTKH nPOTHB ApYFHX HHCjJeKuuli, Taic, Perm (1919),
Benue.nb (1926) coo6luHJIH, 'ITO BBejienne I1poTU6oduPTepuunou Cbl-
6OpOTICII yJIy'IIHaeT o61uee COCTOSIHHe co6aK, 6OJIbHbIX 4yMOI3, TITO
oTpvuaIOT KJIeIiH (1921), 5IKo6 (1928) H Jp.
F. B. BypKCep (1930) ycnenino BBOAHJI LIyMHbIM co5aKaM C TIT-
}KeJIbIMH HOpa}KeHIISIMH JIerKHX no 5-10 MJI no/lu6aJleHTno1 anTU-
CTpenTOKOICKO80Fl Cb160p0TKII, a H. H. OpJIoB (1926)-6uea/teuTnyF0
Cb68OpOTKy IcpynHoeo poeaTO2o CKOTCI nPOTUB naCTepe/lile3a c8Uneu
U Kyp.
CoTleTaHTIe CHMnTOMaTII'ICCKOro JIe'IeHHH C BBeAeHHeM npOTU80-
cu6upeSl3eennoa Cbl80POTKU (1-2 pa3a B Jelib no 5-10 MJI), no
AaHHbIM A. K. gaHHJIOBa (1953), 4epe3 3-7 AHeFI npHBeJio K H3JIe-
tIeHHIO 294 H3 478 co6aK, 60JIbHbIX TiVMOI3.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
LIo coo6HjeHHlo Cae6epra (1927), B aaHHH upH qyMe HJioTOxA-
UIbIX yCHeuIHO FIPIIMeH51IOT Cb68O)OTKy npOTUB nonoca TCJIS1T B A03ax
5-10 MJI 5 pa3 B TeEieHHe 48 gacoB.
Xopoulue pe3y4bTaTbI HOJIyLIHJIH DOHT3Hb (1926), H. E. Py6HH
(1950) npH BBeAeHHH B A03aX OT 2 go 5 MJI Cb16OJOTIUI IipOTU6
+lyA bt caUKeu.
HofbITKu HPHMeHSITb HPOTHB 9yMbI HJIOTOAAHbIX npOTUBOJvtbITHywO
Cb16OJOTKy (,qHq)q)H13, 1904), npOTU6O2pUnIlO31ly1O JiowadUhty.O Cbt-
BopoTKy (SIKo6), cu6upe 136eulkyio npetyunuTUpyrou?ylo cbtBOpOTKy,
4Lbl6OpOTKy npOTU8 3JHC/)U3eAaT03ko20 Kap6uuKyula, Ko.iu6al4uJiJ7e3a u
napaTUC/Ja TBJISIT (,jaHHJIOB) He YBeH4aJIHCb yCneXOM.
Hop.FlaJlbnawt CbI6OpOTKa 11otuaOu PeKOMeHAyeTCA Ma.lbueBbIM,
XoJIMaIICKnX H gPyFHMH AByX-TpeXKpaTHO, B A03aX 10 MJI Yepe3
Ka}KAble 2-3 ANSI.
OAHaKO y~Ke LLIaHTbIpb (1891), OpJIOB, MaK-ApT (1920), Mai
(1921) H ApyrHe nOKa3aJIH, qTO npHMeHeHHC HOpMaJIbHO1 JIOIHaAH-
HOi CbIBOPOTKH Y TOJIbKO 'ITO 3a60JIeBLIHX co6aK He noBbImaeT HpO-
IjeHTa BbI3,UOPOBJIeHH5I. TeM He McHee, HOrIbITKH HPHMeHCHHSI HOP-
MaJIbHOi JIOHIaAHHO11 CbIBOPOTKH npOAOJDKaJIHCb. BeHueJlb yKa3bIBaJI
Aaxce Ha IIpeHMyMeCTBO HOpMaJIbHOi CbIBOPOTKH nepeA CneuHCpH9e-
CKoi, A. H. MaxapescKHi (1925), A. A. BorJ lHoBcxni (1925),
B. A. COKOJIOBCKHcI (1928), Byj (1929), C. A. EapaHOB (1935)
peKOMenj yK)T ee B A03aX 2-3 MJI Ha HH"beKLWIO; 6oJIbrnne A03bl,
710 MHeHHIO BoraaHOBCKOPO, ae 1CTByIOT yrHeTaIOLue.
IIo Ha6JnoAeHHnM O. C. KopoTH4a H apyrHx (1939), TpowwHxHFIa,
H. F. 3anawHloxa (1946), OHa He AaeT 3(pcpeKTa y co6aK H JIHCHu
,aa>xe B HaqaJlbnoi CTaJiHH 3a6OJIeBaHnH H HpOTHBO1OKa3ana npn
nOpa)KeHHHX ueHTpaJIbHOi HePBHOi CHCTeMbI, rIHeBMOHHH, Anappee
If Apyrnx UPORBJIeHHHX BTOpH'IHOi nHCpeKUHH. TeM He McHee, HeAaB-
KO AAaMaHHC (1950) BHOBb peKOMeHAOBaJI HHbeKIjHH HOpMaJIbHOI1 JIO-
IHa,aHFIOi CbIBOpOTKH-HO I MJI nOA KO)Ky qepe3 AeHb; B OnbITBX aa-
HHJIOBa BBeaeHHe HopMaJlbHOi JIOLIIaAHHOI1 CbIBOPOTKH Aaxte Ha
9-12 aeHb 6oJIe3HH H3JIe'IHBaJIO Co6aK, 60JIbHbIX TIyMOi.
A. 14. ,qyKaJIOB ycneHJHO HCHOJIb3OBaJI HopJIlaJlbHy!O CO6atlblO Cbl-
OOpOTKy AJISI JieveHHi TIyMbI co6aK.
Ho Mr,ielo (1926), 6blJla 3CJgJeKT:4BHa TaK)Ke nopJvtautbna5t cblBO-
pOTKa ceunea B A03ax 20-30 MJI H nop,iamnau Cb16OPOTKa Kpyn-
noco poearoeo CKOTa, no AaHHbIM (Da6peTTH (1939).
PE)KHM COAEP)KAHM 1 H KOPMJIEHHE )KHBOTHbIX,
BOJIbHbIX 4YMOH
BOJIbHble tIyMOi }KHBOTHble ROJI>KHbI COAep}KaTbCH H30JIHpOBaHHO;
co6aKH-B CyXOM, TenJIOM noMenjeHHH, npH paBHOMepHOI TeMnepaTy-
pe He HnxcelO-12?. 4HCTOTa, OTCyTCTBHe CKBO3HHKOB, xopowlasi BeHTH-
JIHIJHH, 6bICTpaI H TLuaTeJlbHax y60PKa BbIAeJIeHHi, gaCTaB CMeHa
IIIOACTHJIKH, oxpaHa 6OJIbHbIX OT npOCTyjjbl, KOPOTKaH nporyJiKa B XO-
poiuyio noroAy (BMeCTO KynaHHSI-TLuaTeJIbHaHi 4HCTKa H paC'ecbi-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BaHHe)-OCHOBHble npaBHJIa couep}xanxx }KHBOTHbIX, 6OJIbHbIX
ggyMOK.
KOpM AoJI}KeH 6bITb nHTaTeJIbHbIH H JIerKO nepeBapHMblli c
6OJIbn1HM KOJIH~IeCTBOM BHTaMHHOB (MOpKOBb, KanyCTa HAP.); MOJIO-
KO, 6yJIbOH C }KeJITKOM; npH nopa}Kellnxx KHHIeLIHHKa-H McHHbIII
HJIH OBC5IHbII3 Cyn, KHCJIOe MOJIOKO, TBOpOr, cnwroe MOJIOKO, MOJIOKO,
Jiy,IIIIe a1LHAO4)HJIHH. MSICO H3 pawHOHa He HCKJIK)gIaTb, HO L aBaTb B
orpaHH'IeHHOM KOJIHggeCTBe-4O-200 r B CyTKH B BapeHOM HJIH py6-
JIeHOM, napOBOM BHAe? HMeIou&HeCH B JIHTepaType yKa3aHH5I Ha BpeA-
HOCTb MHCHOII fHUJH MaJIO 06oCHOBaHbI. HanpOTHB, 'ITO6bI H36excaTb
TSuKeJIOro HCTOmeHHH, yrpo}KaIon1ero 6OJIbHbIM C06aKaM, Ha,L o Ra-
BaTb MHCO, TaK KaK OHO 06bIgHO SIBJISIeTCSI eAHHCTBeHHOI3 nHHI,eHI, KO-
TOpyK) OHH erne noeaaiOT, CJIa6bIM-AaBaTb HeMHOro aJIKOFOJIff. aJISI
nHTbH-OCTy}KeHHaH KHnSIYeHaH Boaa c 0,5% RByyrJIeKHCJIOIi COAbl.
OCTaTKH KOPMa H BOJ[bI HeMeAJIeHHO y6HpaTb. O6H3aTeJIeH pbI6HII
}KHp. npH nOJIHOM OTKa3e OT eubl-HHTaTeJIbHble KJIH3MbI.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
FJJIBz1 CENTH,'UILlAT,1H
MEPbI 6OPbbbl N HPO4)HJIAKTHKA
~(~ (~e rHBIiaA 60pb6a c 'iyMoil HJIOTOA!IIIbIX Tpc6yc'r HpOBejCHH51
KOMIIJIeKCa BeTepHHapHO-calln'rapllblx, 300I'HrHC1lF14CCKHX H HpoTHBO-
Or1H3001HtiCCKHX Meponp[IHTFH`i 110 BbIpaLIIHBalIH!O KpeHKOro, 3JIop0-
BOLO, yCT010l1IBOr0 K IIH(f)eKIIHII HoI017101 bA ?KHBOT1IblX, HpaBHJIbHOrO H
HOJIHOIICHHO['0 KOpMJIeHHR, XO9OIIIHX yC,'IOBHiI (ojlCp?KaIIHS{ H VXOJja,
HpenjyI1pe)+K,RCHH2 3allOCa ilyMIIOi HII(JeKI[HH B 6JiarOHOJly9Hble
X03911CTBa.
f 111 1,,0311HKHOBCHIiC, paCHpOC"rpalleI 1Ic H Tc'ICIIHC'Iy11Ib1 HJIOTOB4IIbIX
BJIHSICT CTCiICHB eCTeCTBCIilIOI1 9C3HCTCHTIIOCrFI BOCHpHHM!IIIBbIX }KH-
BOTiIbIX: 01111 BbII:IC, TCM MCHb1HC 3x60.-IC3aeT C06lK, JIFICHII, H
ApyFHX BOCHpHHMLIHBbIX }KHBOTHbIX H TeM MCHee 3JIOKa'ieCTBeHHO Te-
'IeHHe 'IyMbI. OCHOBHbie HpaBHJIa pa3BeJjeHHA, CH0006CTBy1OHjHe BbI-
paHII1Ba:I1HO 3;JOpOBbIX }KIIBOT1lblX: He rHa'rbCA 3a KOJIH9eCTBOM H He
OCTaB.IA'rb Ha HJIeMSI 1103JIHHX MCIIKOB (po;jaBIIIHXCA B HIOIIC-HIOJIC),
He JjollyCKaTb TCCIIOI'O HH6pHJIHHra, IIOJ16HpaTb JIJIA BA3KI1 IIpOH3BO-
JjHTeJleli C KpeIIKOIi KOHCTHTyLIHeH, 1,136eraTb paHHero OT-bCMa
M(JIOJHSTKa.
Hco6xo)jHMbiM yCJIOBHCM HOJIJjCp>KaliIlSl XOPOIHerO 3J&O9OBbA CO-
6aK, JlriCllll it ipyl'Hx HJIOTOSIJj1lbIX }KHBOTlIbIX 5IBJIAC'ICA KOpMJIeHHe HO
pa3H006pa3FibIM palIHOHaM, COJICP}K1UjrIM Hco6xoJjHMOC Ko.:IH9eCTB0
6eJIKOB, 3KHpOB, yFJICBOJgOB, BHTaM11110B H MFIHCpaJlbIIblX BCIIjCCTB,
COCTBr:ICHIIb1M B 38P,HCH1110C1'H 01 5031,3acTa, 1KIIBOro BCCO, 1ia311a'le-
IIHA 11 paooTbl, KOTOpy10 b'b!HOJIHAIOT COO1KII Id Jjpyrlie iKHBUT11bl(. He
CJICJjyCT JjOII\CKBTb K CKap\JJIHBalIHIO co6aKa1 it IlyillllbiM 311C1)5M
MACO, IIp01lCXOj5LIICC OT AKHBOTHbIX, BOCIIpB1,I.3I'IIIBhlX K 'IVMC IIJIOTO-
AJIIIbIX.
13 ('1451311 C JjaJill b1p111 3,TbTOHa (1931) H OCO6CIIHo MapT)Ha
(1953) 0 JUT1ITCJIbl1OM JI1TC11TI!OM IIOCHTCTII,CTBC BllpyCa 'lyMbi HJIOTO-
5U HbIX IICKOIOpbiMH rpbl3VHaMl1 TyIIIKH 3TIIX 311CpbKG3 He Jj0JI}KHbI
JIouyCKaTbCA K CKapMJIIIU'1HJJo 6C3 'III!,WAblIOFO ITCpeFapHB1I1142.
I3O?iblUOe 3IIawHHe HMeeT COJjep}KaHHC B KOpMe BHTaMHHOB H
MHKpo3JleMCIITOB. TaK, TIOHTCp (1948) pCKOMleli,:jyel' BBeCTH B pa-
1HOH co6IIK TOM3TbI H COK 113 oBOLgeil, 6O1-aTbIX BHTOMHIIaMH A H C,
H MHKp03JICMCHTbI }KeJle3a, MCJjH H KpeMlleB011 KHCJIOTbI. CJIaJ(KHFI
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Koipe, no MHeHHIO MHOrHx aBTOpOB (M. H. MaxapeBcKHll, 1925, Hap.),
noJle3eH AJI51 weHKOB-orbeMbluleH.
I1OHJIKH, KOpMYUIKH, MHCKH H rip. AOJI)KHbI 6bITb HHaHBHayaJlb-
HbIMH )Jl51 Ka)iaou co6aKH, JIHCHUbI H apyrHX )KHBOTHbIX H nOCJie
Ka>K,aorO ynOTpe6JIeHUI1 HpOMbIBaTbCH KPYTbIM KHUIITKOM.
B 3BepOBoJ eCKHX H C06aKOBOageCKHX XO3III[CTBaX Haao CHCTeMa-
TH'-IeCKH yHH4TO)KaTb MyX H apyrHX KpOBOCOCYUZHX HaceKOMbIX H
KJIe1I(eii npH noMOHjH ,p,T, reKcaXJlopaHa, aKTHBHpOBaHHOrO
KpeOJIHHa.
Ba)KHeIIUIHM 30orHrHeHH4eCKHM Tpe60BaHHeM JZJIH 3BepOBOa-
4eCKHX H co6aKOBoa4ecKHX X03BIiCTB IIBJIHeTCSI KpyrJIOro,II 1HOe CO-
JZep)KaHHe cO6aK, JIHCHIZ H apyrHX )KHBOTHbIX Ha OTKpbITOM B03ayXe
B HpOCTOpllbIX BOJFbepax (KJIeTKax), CHa6)KeHHbIX XOPOIHIO o6opyaO-
BaHHbIMH AOMHKaMH H apyrHMH noMeweHHfMH (naBHJIbOHaMH) HJIH
6yAKaMH RJI51 CHa H yKpbITHII OT HenorOabl.
BaxcxelfHlef npogJHJIaKTH4ecKOI3 Mepoli SIBJIxeTCH npeJl,ynpe)Kae-
HHe 3aHOCa HH(JeKLIHH H3BHC' Ha TeppHTOPHIO X035FKCTBa. B CBH3U C
3THM 6oJlb[llylo pOJlb HrpaeT yCTpOHCTBO 4JyHaaMeHTaJIbHO17O 3a6opa
BOKpyr TeppHTOPHH X035IuCTBa, 4TO HCKJIIO4aeT HpOHIIKFIOBeHUe 6po-
a5I4HX co6aK, KOIHeK H J FIKHX )KUBOTHbIX. H3 J PYFHX Mep 60pbCbl C
4yMolI Ba)KHOe 3Ha4eHHe HMeeT yCTpaiieHHe KOHTaKTa C HeU3BeCTHbIMU
co6aKaMH H aPYFHMH >KHBOTHbIMH, 3anpeiueHHe Bxoja Ha TeppHTO-
pHIO XO35IIICTBa HOCTOpOHHUM JIHIjaM, o6eCHe4eHHe o6C.ny>KHBaloluero
nepCOIIasia COOTBeTCTByIOUJ L[ Cneuoae)KAOII (XajiaT, KOM6HHe3OH,
O6yBb, pyKHBHH,bI Hap.), Bb16paKOBKa TaK Ha3bIBaeMbIX KXpOHHKOB>,
y1IH4TO)KeHIIe 6poa5j4HX co6aK H KOFHeK, a TaK)Ke KpbIC H MbImefl. B
3BepoxO35IlICTBaX ai a, HenOCpeaCTBeHHO ConpHKacaIOnUlecFI C nyHl-
IIbIMU 3BCPHMU, He aOJT)KHbI COaep>KaTb Co6aK. HMeIOUjHeCSI >Ke co6a-
KU y apyFHX JIUI1, J OJI)KFIbI cOaep}KaTbOSI Ha npHBH3H H e>KeMeC5IOHO
noaBCpraTbcu BeTepHHapHOMy OcMOTpy (B. K. HOBHKOB, 1952).
O65i3aTeJIbHO{ MepOH 51BJIIIeTCH KapaHTHHHPOBaHHe BHOBb nOCTy-
naIO11[IiX B X03HliCTBO c('o6aK, JIHCHU H apyFHX >KUBOTHbIX H TepMO-
MCTpUA HX B Te'eHHe He Mel-lee 3 HeaeJlb.
B HVHKTbi BpCMCIIHOFT KOHReHTpaL1HH co6aK H HyilIllblX 313epeL1
(Bb1CT 'BKH, BbIBOjKH, COCTII3aHUTI, UIKOJIbI Hap.) peKOMeHayeTCSI JO-
nyCKaTb TOJIbKO HMMVHIIbTX (npHBUTbIX, no KpaIIHCi Mepe, HaCCHBHO)
>KHBOTHbIX, HpOllleaU1HX BeTepHHapHbllt OCMOTp. IIpH KOMHJIeKTOBa-
IIHH IIIKOJI, Upuo6peTe1lHH co6aK H ap. 1(CJIecoo6pa3H0 OHpeaeJleHUe
HX HMMyIfOJ10rFI4eCKOI'O CTaTyca nyTeM HCCJIeaOBaHHH CbIBOpOTKH KpO-
BH CO6aK Ila IiaJIH4He npOTHBO4YMHbIX allTHTeJl (nOCTaHOBKa peaK-
U,HH reMOarrJIIOTHHaUHH) .
BbIUBJIeHHe H perHCTparwu 4YMHbIX o iarOB - Ba)KHOe 3BeHO B
CHCTOMe Mep 60pb6bI C 4yMOFI HJIOTOHaHbIX. B X03IIllCTBaX, He6Jiaro-
nOJIy4Hb1X HJIII HOa03pUTeJIbHbIX HO 3a6oJIeBaHH1O 4yMOli, 6OJlbnbie )KU-
BOTFIble J OJI>KHbI 6bITb nepeBeaeHbI B U30JI51TOp HJIH BeTepHHapHbll1 Jia-
3apeT, a nOaO3peBaeMble B 3a60JIeBaHHH (FlanpHMep, OTKa3bIBaIOU1,He-
C51 OT KOpMa H ap.) HaXOaHTCSI 3 HeJeJIH B KapaHTHHe. OCTaJIbHoe
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
noroJlOBbe B TeL1eHHC 3TOFO BpeMeHH cJiejjyeT coJ[ep}KaTb noA BeTepH-
HaPHbIM Ha6JIIOJieHHeM C e}KeAHeBHOfl TepMOMeTpHell. ECJTH HMeeTC 1
BO3MO}KHOCTb, ueJ[e0006pa3HO 143 KJICTOK H BOJIbep, CMe}KHbIX C He-
6J[arOnoJIyTIHb1MH, BbIBeCTH 3J[OpOBbIX }I{HBo'rHbIX B apyrme noMeHZe-
H115I HJIH BOJ1bepbl. Ha He6JIarOnOJIyLIHble no 4yMe X03H1'ICTBa HaKJIa-
JjbIBaCTCH KapaHTHH. KapaHTHH MO}KeT 6bITb CHHT no HCTe'IeHHH
1,5 MeC. CO JHH nOCJIOJjHCro CJIygafl BbI3,aOPOBJIeHH5i HAM naJjex{a 6oJIb-
IIOFO }I{HBOTHOFO. HpH 3TOM 06H3aTeJIbHbIM yCJIOBHeM HBJIHeTCB OTCyT-
CTBHe XpOHHLIeCKH 6oJibHbIX. EcJIH HMeeTCH BO3MO}KIIOCTb, npOJ[OJI}KH-
'reJlbl[OCTb KapaHTHHa Lje.necoo6pa3HO yJjJIHHHTb Jjo 3 MeC., T. e. Ha
MaKCHMaJIbHbIH CPOK yCTaHOBJIeIHOI'O BHpyCOHOCHTeJIbCTBa, H B TelIe-
HHe 3TOr3 nepHo;ja He JOnyCKaTb HH BBOI a, HH BbIBOJja }KIIBOTHbIX.
CaIIHTapioe COCT051HHe ne6JiaronOJIy'IHblx no LIyMe X035IHCTB
J[OJI}KHO 6bITb yJlyI-IHIeHO. MeCTa, rj[e COJjep}KaJIHCb 6oJIbIIble }KHBOT-
nble (naBHJIbOHbI, KJICTKH, BOJIbePbI H 1'. H.), BbIJlCJIOHHH }KHBOTHbIX,
OCTaTKH KOpMa HCO6XOJHMO Ta aTeJIbHO Ae3HH4)HUHpOBaTb. BeCb HH-
BeHTapb HO yXOAy 3a }KHBOTHbIMH (BeJpa, KOpMYIIIKH, rIOHJIKH
11 T. Jj.), cneuoJe}KJja neDCOHaJla THK)Ke JjOJI}KHbI CHCTeMaTHgCCKH J1e3-
nHCjHgHpOBaTb05I. HepeJj CII5ITHeM KapaHTHHa o6H3aTeJIbno npoBeJje-
HIIe reHepaJIbHOH 3aKJIIOgHTeJIbHO1l OLIHCTKH H ae3HHCpeKUHH Ha Tep-
PIITOPIIH Bcero XO3HIICTBa.
B ne6JlaronoJlytlnblx no lfyMe XO35IHCTBaX MepbI cneUHC~HHIecKOH
TepanHH H np04JHJIaKTHKH peKOMeHJ[yeTC51 OCyWeCTBJIHTb no CJIe-
,ayloLue1l cxeMe: noroJiOBHaH TepMoMeTpHH BceX BocnpHHMqHBb1x K
LIyMe }KHBOTHbIX, BBeJjeHHe rHnepHMMyHHO11 CbIBOPOTKH BCeM HJ1eMeH'
HbIM H JjPYFHM UeHHbIM }KHBOTHbIM, BOCnpHHMqHBbIM K '-iyMe HJIOTO-
HAHbIX, npoCpHJ1aKTHTIeCKaii BBKUHHaLjHH BCeX 3JIOPOBbIX }KHBOTHbIX
(r[OJIy4HBLHHe npeABapHTeJIbHO CbIBOPOTKy nPHBHBa1OTCH BaKUHHOH
,iepe3 3-5 JIHeH) ; JiewHIIe 60JIbHbIX }KHBOTHbIX CbIBOPOTKOH HJIH BaK-
UHHO1I H cHMnTOMaTHgeCKIl.
Ho HOBHKOBy, B 3BepOX035IklCTBe, B KOTOPOM 6blJia BcnbILHKa
'lyMb[, KOMUJ1eKTOBaHHe nJ1eMeHHOFO HOI'OJIOBbH H FOH cJiejjyeT npO-
BOJLHTb TOJIbKO BHyTPH OTJ[emmeHHH H Ile JjOnyCKaTb nepeBOJ 3J1,OpOBbIX
3BepeF H3 OTJjeJ[eH11H B OTJjeJIeHHe, a TaK}Ke H3 ceKUIIH B CeKUIIIO.
Ha KpalineM CeBepe, rue qyMa FIJIOTOHJI,HbIX B CJIyLIae 3nH300TH-
i1eCKOFO pacnpoCTpaneHHH np1HHMaeT Xapal{Tep nOJ[JIHIIHOrO 6eJj-
CTBHSI, Heo6XOJU1MO H3J[aHHe 06H3aTeJIbHbIX peLHeHHII McCTHbIX COBe-
TOB o npeaynpe}KJeHHH H JInKBHJaunH 3a6OJIeBaHnH. B 3THX peHle-
HHHX npeuyCMHTpHBaeTC51 o6'bHBJIeHHe nyHKTOB, He6JlarouoJly'IHbIX
no 11yMe nJI0TO51AHbIX, Hai-o}KeHHe Ha HHX KapaHTHHa, o6H3aTeJIbHaH
perHCTpaIwH BCeX c,nygaeB 3a6o.leBaHnH H naae}Ka C06aK H apyrHX
BOCnpHHMLIHBbIX }KHBOTHbIX, 06513aHHOCTb BJia)jeJibueB 60JIbHbIX }KH-
BOTHbIX OTJjeJIHTb HX B oco6oe, oTBeJjeHHoe JjJ151,3TOH UCJIH McCTO, y6H-
PaTb H yHH'ITO}KaTb TPynbl co6aK, ae3HHCPHUHPOBaTb npeJ[MeTbI yxoaa
3a }KHBOTHbIMII H ynp5i}KH co6aK, noMelueHHI H McCTa, r, e HaxoaH-
JIHCb 60AbHble }KHBOTHble; B yrPO}KaeMbIX HaCeJIeHHbIX fYHKTaX ueJie.-
c006pa3HO OTBOJjHTb OCO6ble McCTa ,IjJI}1 nPHBH3H H coJjeP}KaHHSI
e3JOBbIX co6aK.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B He6JlaronoJlyLIHbIX nyHKTax ycTaHaBJIHBaeTCH CTPOrHA pex{HM
coAep}KaHHSI co6aK Ha npnB 13H, BOCnpeu eHHe B'be3Aa H Bble3Aa Ha
co6aKax H3 He6JlaronoJlyIIHOfI McCTHOCTH.
TaKHe o6H3aTeJlbHble penleHHSI, HCXOASIH.[He OT OpraHOB McCTHOFI
BJIaCTH, 6e3yCJIOBHO, HrpaIOT 60JIbIHyfo HOJiO}KHTeJIbHyIO pOJIb B 6opb-
6e c 1IyMOH nJIOTOflAHbIX.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
UI'THPOBAHHAR JiHTEPATYPA
A B a x 51 it A. A. B KH. M, 1953, c. 6.
A B n a is y Ni O B M. E. it B o r o n to 6 o n a B. M. COB. BcTCpuiiapna, 1938,
.N- 2, c. 67-69.
A;, 't a it It c 13. (D. B KB. CiipaaovHIIK BeTepuHapiioro Bpaaa, M.-A., 1950;
1953.
A io A. J]. AuTnrCM,I KaN Spe3Bbi La0Hbie pa3,tpa>KIITe 1 l nCpBHON CHCTe-
Mbi,
M., 1952.
A K y rt 0 B A. B. B Tpy;2ax LIHI iJI 3BCpOBO,-jCTBa, 1950, B.
N TI, c.
198-200.
A K y .T o B A. B. B i:H. Bosib B. K.
HaTO.-IOreanaTOMIt IeeKKOC BCKpbITHC'
ce.3bc!:r,xo_ tIHCTBcuubix >K!!BOTItL X, M., 1953,
c. 190-192.
A it e K C e e B
A.
CcB. KBBK. BCCTH. BCTepinHapnil,
1930, J'4 IV-V, c. 17.
A H p e p c e ii
(P.
A.
Co6aKOBOACTBO H
ApeCCHpoBKa, 1927, JN4 7. c. 5.
A H T 0 11 0 B
Al.
H. it
B a B n Ji W 9 C B
10. B.-BeTCpnHapHI, 1952, Nk 6,
c. 41.
A p x a it r C .1 h C K H 0 H. HpaKT. BCrcpHHapnH, 1906, c. 306.
B a ii c p B. BeTnpav, 1906, No 17, c. 263.
b a K iu it T. E. 3axaiolieHne o npHMelieHHH BaKUHHbl BHIIO, 1952 (pyKO-
rntcb).
B a K Iii H JI. E. CHIITOMHUIIH itpH HOpa>KCHHiIX KHHIe9HLKa y co6aK, 1953
(pyxonncb).
B a p a it o B C. A. COB. BeTepuifapiui, 1935, No 9, c. 84.
B a C K a K O B C. A. Tpyi ui Knponcxoro 30OBCTUIICTHTyTa, 1940, T. IV,
B. 2(14), c. 237-239.
B c A o y c o n B. OxoiHBK it nyuinni< C116npn, 1925, INS 5--6, c. 35.
Fie p n c'r i1>. M. Bi!pyc KaK Opranll3M (nep.), M., 1943.
1) o r A a H o it H. H. ApXnu BeT. HayK, 1911, KU. 12, C. 1500-1504.
B o r,2 a it o n c iC it ii A. A. bc.,iopyccKaii BcTep!Hiapun, 1925, Ns 1, c. 10.
b O JT I, K. 1'. K nollpo v o riaT0JROrcanaTOMU9CCKHx n3MCIICHIIAX CrHHHOrO
MO3ra npn vvMe co(ai., 1899.
13 o Iu b r it Y. M. () Iipnpoac BHpyCOB n MI1KpO60B, M., 1949.
B Y JI V a K o II K. A. }Kyp!i. oxoTbi, 1875, A=S 2, c. 71.
B y p K c c p F. B. YK~InnCKIL0 OXOTIIIIK H pbi60,10B, 1925, No XI, c. 19.
IS y p is c c p 1'. B. HpaKT. BeTCp!inapim, 1930, c. 202.
B V 11 It C B K. H. ,ITpYubl j_(a.TbHHBH, 1949, T. II, C. 113.
b y in y e B M. C6oputu< , 1928, Al, 1, c. 17-18.
Ii P K013 K. Al. Kopa roJLOBHOrO Moira II BHyTpCHHHC 01)FMI L, M., 1944.
b CI C T p o B B. A. COB. Berepmiapnn, 1940, No 11-12, c. 40.
B a r it H Ll. HpaKT. BCTepiui., 1929, No 9, c. 792.
B a .T J n iir e p. PaCCy>Ku.e!ii!e o6 O6hiKHOBCiiHbIX 6ouue3HAX co6aK, 1834.
B a 11 H 0 B C K It fl T. N. COB. OXOTHHK, 1940, No 6, c. 44-47.
B a H H 0 B C K It it T. B1. B Kit. , 1941, c. 119-147.
B a cm Ji eU SI. E. BeTCp. Ai.To, 1924, No 14-15, c. 82.
B a c ii it e u R. E. YKpanacKHK OXOTHHK H pbl6oJnoB, 1925, No 3, c. 32.
B a c H n b e B 10. Co6aKOBOACTBO, 1932, Ns 3, c. 4-7.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B H W H e B C K 11 1 K. H. Bu j. }KH3Hb, 1911, Ne 13, c. 205---206.
B if a a 11 M It d o B B. E. BeTepnHapHH, 1949, Ns 7, c. 59.
B 0 it H H A 0 B H q H. 3eMneJjenb4. ra3eTa, 1849, NI 6, c. 47.
B o n K 0 B a A. M. B c6OpHHKe Hay'HbIX TpyAOB I4BaHOBCKoro CXI'I, I'IB.
1956, Ns 15, c. 187-199.
B p a H r e if b (1). H. I-IyTeIIIeCTBHII rio ceBepHbIM 6eperaM CH6HpH H no
JIeAoBHTOMy MoplO, conepiueHHbie B 1821, 1823 H 1824 rr., CIIb, 1841; M., 1948
(2-e H311).
B c e B 0 n 0 A 0 B B. H. OnbIT y4eHH51 0 nOBanbHblX 6one3HAX cpeju AOMalll-
HHX NCHBOTHbIX, Cr115, 1840.
B bi r 0 A V H K 0 B F. B. MHKpo6HOJIOrHn H HMMyHOJIOrHH CTa(pHJIOKOKKOBbIX
3a6ojieBaHHit, M., 1950.
B bi in e if e c c K H 0 C. H. H Ap. i-IacTHaa 3nH300TOnorHH, M., 1948, 1954.
F a m a if e n H. (D. HH4)eKUH$I H HMMyHHTeT, M., 1939.
r a H H Y In K H H M. C. O61ljaH anH300TOnorHn, M., 1948.
F a y n T F. B KH. KJIHMMep M. Y4enne 0 3apa3Hblx 6one3HHX cenbCKOXO-
3BOCTBeHHbIX }KHBOTHbIX (riep.), M., 1931.
Fen e p 0 3 0 B B. $1. C6. OxoTa H OXOTHHK, M., 1925.
r o n y 6 K 0 B B. COB. BeTepHHapHSi, 1939, N9 8, c. 77.
I- 0 H A a T T H H. 3aHHCKH 1-IpHaMypCKOrO OTA. PyCCKOFO reorpa(4HV. o6-Ha.
1887.
r o p a H C K H 0. OxoTHHybe Aeno, 1923, Ns 3, c. 20-21.
I' o p 6 e H K 0. Co6aKOBOUCTBO, 1932, Ns 10-11, c. 18-19.
F P H r o p b e B. CoseTCxoe X03aOCTBO, 1928, N9 8-9, c. 107-108.
F P H H 6 a y m CD. r. B KH. TpygbI KOH(pepeHUHH no HanpaBneHHO}ci H3MeH4H-
BOCTH H Ce.TIeKUHH MHKpoopraHH3MOB, M., 1952, c. 92-101.
F p H Iij e H K 0 B E. JI. B KH. PyKOBOACTBO no IIOJjroTOBKe cneUHaJIHCTOH
cnyxce6Horo co6aKOBOACTBa, M., 1941, c. 186-189.
F p H Ilj e H K 0 B E. A. B KH. Cnpice6Hoe co6aKOBOJjcTBO, M., 1945,
c. 174-178.
T p io if e p C. A. ApxHB net. HayK, 1915, KH. 11, c. 1384-1429.
r p io H e p C. A. B KH. r. Mionnep 3Aopoeaa co6axa, BHTe6CK, 1929,
c. 203-218.
r p 1o H e p C. A. Co6axOBOp.cTBO, 1930, N9 1, c. 1-3.
r y 6 H H H. M. B KH. FIOJHOC pyKOBOACTBO HO nCOBON OXOTe, M., 1890.
r y c a p e B H ii (D. OXOTHHUHN BCCTHHK, 1918, Ns 7-8, c. 91-95.
Jj a if m a T 0 B M. K. I1paKT. BeTepHHapnr H KOHeBOACTBO, 1927, No It,
c. 29.
J1 a H H n o B JI. K. MaTepHanbl no npo(pnnaKTHKe H TepanHH 'IyMb1 co6aK,
JI., 1953 (aBTOperji. KaHA. AHccepT.).
A e Be Jib. ApxHB. BeT. HayK, 1898, T. 3, 11, c. 65.
e j 10 n H H A. B. Cb1BOpOTKa npOTHB 9yMbi co6aK (UHT. no (D. H. Opno-
By, 1922).
Jj e m H A 0 B H, 3KOH. 3an., 1854, Ns 34, c. 270.
R 3 a c o x o B F. C. Tpylbl BoeHHO-BeTepHHapnof axaA., M., 1947, T. V,
-c. 345-346.
Jj M H T P H e B K. H. B KH. B fOMOlUb BONCKOBOMy BeTBpaUy, 1942, c. 54-56.
.L J o 6 p o i3 O n h C K H 0 H. ,. 3KOH. ?KH3Hb aanhHero BOCTOKa, 1927,
N4 12, c. 42-50.
o n r o B o-C a 6 y p 0 B H. 3eMneaenb4. ra3eTa, 1848, No 66, c. 321.
Jj p e M H U K H 0 H. IIpaKT. BeTepHHapHR H KOHeBOACTBO, 1927, NI 3,
c. 83-84.
p C M II U K H fl H. BaKUHHaUUHH co6aK no rIyHTOHH (UHT. no YBapony,
1929).
,U p e M ft if K H N H., P a 3 y M 0 B C K H H H. TpyAbi BoeH. BeT. H.-H. y4p0K-
AeHHH PKKA, 1931, T. II, c. 16.
A y 6 H H C K H h B. H. UHT. no BaCKaKOBy, 1940.
,a y 6 p 0 n c K H 0 A.. H. 1438. Pyccxoro reorpa4)H4. o61ueCTBa, 1937, T. 69.
Ne 3, c. 447-457.
A y r H H. CO6aKOB0ACTBO, 1932, N 3, c. 11.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Il y K a it o B A. H. BeCTH. coap. BerepnnapHil, 1928, c. 600.
J~ y p a c 0 B H. 3eMJteJe.lb9. ra3eTa, 1848, N9 41, c. 326.
E p M 0 JI b e B a 3. B. (peg) CTperITOMHUHH H HOBble aHTH6HOTHKH, M., 1953.
E 4) p e m 0 B B. B. TpyAbi Bcecolo31109 KOH(pepeHUHH no BIITaMHHaM, M., 1939,
c. 224-225.
E. III. Co6aK0BogcTBO, 1933, N 1, c. 24.
)KAaH0B B. M. H 6: 1 iHT P. C. ?KMBH, 1950, N9 9, c. 40.
>1K A a H 0 B B. M. 3apa3Hble 6OJIe3H11 'ICJlOB Ka, M., 1953.
>K ,R a H 0 B B. M. OnpejwJIHTeJIb BHpyCOB 'ieJIOBeKa H }KHBOTHbIX, M., 1953.
>K Y K 0 B - B e p c K it 11 K 0 B H. H. it (P p m a y (p B. A. BeCTH. MHKpo6HOJ1..
3n1I;1eMHO.l., napa3HTOJIornH, 1934, T. XIII, B. 4, c. 263-269.
3 a n a A H 1o K H. B. BeTepuHapna, 1946, 2 10-11, c. 33-34.
3 A P O A 0 B C K H 0 I7. (D. Ilpo6JIeMa peaKTIIBHOCTII B y'IeHHH o6 HH(peKHHII H
IBMMyHHTeTe, M., 1950.
3 e 0 q) p It A O. Baaui 4mue 60J1c3HI1 Kpo.3UKOB, M.-JI., 1930.
3 e m M e p E. ApxHB BeT. HayK, 1875, B1oHb, c. 118.
3 e it II H C K nit it tpp. ApxHB. BCT. HayK. 1894, T. IV, C. 12.
3 H JI b 6 e p TI. A. OnHJCMH9CCK11e 3Hue(paJIHTbI, M., 1945.
3 n .n b 6 e p JI. A. OCHOBbi HMMyHHTeTa, 1948.
3 11 JI b 6 e p JI. A. Y ieHHe 0 BHpycax, M., 1956.
311JIb6ep TI. A. it BoCTpoyXoBa E. M. >KypH. MHKpo6lto.norIIH It
I!MMylIo6Ho.lornI1, 1933, T. XI, B. I, c. 66.
3 0 JI 0TH H U K H 6 C.- BeTBpao. 1906, N9 2, c. 456.
3 y 6 K o B. H. BbICTynJIeHHe Ha COBC1ua1IHH o BaKUnHaX IlyMbI n.(I0TO3Al1bIX,
1956 (pyxonncb).
H a K o 6 c e H B. Co6axOBOACTBO H ApecCHpoBKa, 1927, N 9, c. 11.
1I B a H 0 B B. E. Hay'IHbie HOBOCTII jaJlbllero BOCTOKa, 1930, No 2-3.
H r H a T 0 B a O. B. CpaBHBTCJIbHOe H3y9CHHe IHTaMMOB naCTepe.1Jt Ce.nb-
CKOXO351BCTBeHHb1X }KHBOTHbIX 11 1ITHU, 1948 (AIICC.).
H 3 p a H .1 C B 11 IT H. E. Co6aKOBOACTBO 11 5 pCCCnp0BKa, 1928, N 4, c. 11.
H H b K 0 B H. M., Co6aKOBOACTBO, 1932, N9 3, c. 14.
H 11 b K 0 B H. M., BeTepllnapnsl 1953, N 4, CTp. 79.
H c a e B B. B. (L1HT. 110 H. H. Pe6poBy. TpyAbl BypaT-,NIoHr. 300BeTIIH-
CTHTyTa, 1939, B. 1, c. 30-37).
K a r a H O B 11 11 5. H. 3aKJIIO'teHHe 0 BaKUHHe BHHO, 1952 (pyKOnHCb).
K a JI It it a F. H. H3MCHIIII13OCTb naTOreHHbix M11KpoopraH113MOB, KHeB, 1949-
K a it H H a F. H. B KB. Tpyjua KO1I(pepeHU1111 110 HanpaBJICHHOO II3MeH'I1l-
BOCTH 11 CCJICKUHH M11KpO0praHH3MOB, M., 1952, C. 82-92.
K a it it H H 11 K 0 B H. (D. HaIH KpauH11 t CeBepo-BOCTOK, CHB., 1912.
K a p c c B C. >KypH. IIMn. o6-Ba OXOTHHKOB, 1879, T. III, c. 53.
Kapit it it 3. K. H AM6ap0B K. C. BeTepHHaplla, 1950, N2 1, c. 43.
K a p n n it 3. K. it A M 6 a p o B K. C. K BonpOCy o TeoeHnn co6aK, 3a6o-
JICBIDIiX 'lyM00. Hay'lu0-npaKTH'L pa60TbI BCTCp11Hap1ION C.ny)K6b1, 1951, C. 78-80.
K a to p. CJIy}Ke6Hoe Co6aKOBOACTBO B VCJIOBHAX ABK, BJIarOBeiueHCK, 1931.
KB a c H 11 K o B H. A. HpnpoAa H oxoTa, 1880, T. III, aBryCT, c. 33-61.
K it 6 c p F3. CB61IpCKIIK BecTHHK, 1824, it. 1, Kit. 2, c. G.
K H p c a H 0 B B. BecTHHK COBPCMCHHOH Be'repnHapnn, 1928, c. 570.
K H y p-M y p a T o B A. H. 1i Kit. TpyAbl HH-Ta 3KCnepBM. BeTepHHap1B,
1940, T. 15, c. 104.
K 11 y p-M y p a T O B A. H. B KB. i-IaCTHal1 3HH300TOJ!OrIIa, noA peg. C. H.
BblIHe.ne.CCKOro, Al., 1940; TO KC, M., 1948.
K i1 y p-M y p a T o B A. Fl. BeTeplIHapHb10 3Hu1K.10neAH'leCKH6 CJIOBapb,
T. II, M., 1952.
K it y 1) -M y p a T o B A. H. H PSI 6 u e B M. A. TpyAbl HB-Ta 3KCnepHM. Be-
TCprIHapHH, 1940, T. 15, e. 104-105.
K it 10 i a p C B B. B. HpaKTn7ecKall BeTCpBHapHSi, 1930, N9 2-3, c. 201.
K JI 1o It a p e B B. B. HpaKTIIOCCKaa BeTepBHapHa, 1928, N2 9, c. 54-59.
K O B a JI e H K o 1. P. HpHMeneHHe 6HOJIOrBYeCKHx B XHMIIOTepaneBTH4ecKllX
npcllapaTOB B BeTepnnapltH, M., 1951.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
K 0 a e C o B C. r. BbICyuHBaHHe MHKpoopraHH3MoB H 6HOnpenapaTOB, M.,
1952.
K 0 A 0 0 0 0 B C K H I7 T. 3aKaK19eHHe 0 BaKgHHe flaHKOBa, 1956 (pyKOnnCb).
K o Ii r e B. B. Co6aKOBOACTBO, 1932, Ns 11, c. 9.
K 0 H r e B. B. Cnpaso'HHK BeTepllHapHOro Bpa'Ia, M.-.I., 1940, c. 127.
K O H A a K 0 B T. A. BeTepHHapHx, 1949, Ns 2, c. 29.
K 0 H A a K 0 B T. A. Tpyubi MOCK. BeT. axaueMHH, 1950, B. 7, c. 152-155,
nnccepT., M., 1949.
K O H A a K 0 B T. A. BaKgHHOTepanHH 4yMb1 co6aK. OT4eT 9KYTCKON HFIBOC
sa 1951 r. (pyKOnncb).
K 0 H e B (D. H. r a3. aeCOBOACTBa H OXOTbI, 1858, c. 389.
K 0 H e B U. (P. BeTepHHapHoe o6o3peHHe, 1912, No 17, c. 657.
K 0 o a b-9 C T H B e H A H. Tpyabl UaabHHBH, 1928, B. V, c. 91-94.
K 0 p H M a H H. E. LHT. HO J1. B. flapaiuyK, COB. BeTepHHapHx, 1939, Ns 4,
c. 47.
K o p o T H q O. C. H Ap. BeTepHHapHa cnpasa, 1939, Ns 2, c. 36.
K0pCaK0B H. flyIHHHa, 1929, N2 4, c. 17.
K O T O B C. C. COB. BeTepHHapHx, 1937, Ns 7, c. 65-66.
K O T O B C. C. K Bonpocy o qyMe co6aK, M., 1939, allcc. (pyxonHCb).
K O T O B C. C. TpyAbl BBAKaA., 1947, c. 354-358.
K O T O B C. C. BeTepHHapHx, 1951, N9 9, c. 23-28.
K o w e B o x B. B. BeCTHHK COBpeMeHHOci BeTepHHapHH, 1928, NQ 3, c. 82_
K o w e B o 6 B. B. Co6aKOBOACTBO H ApeCCHpoBKa, 1928, Ne 6, c. 8.
K o in e B o H B. B. L1yMa co6aK, ee npeAyllpexcueHHe H aeveHHe CbIBOpoT-
KOIl, UIOJITasa, 1929.
K p a e B C K H li A. A. ApxHB BeTHayK, 1882, KH. 1, pa3A. V, C. 1.
K p a C B C K H Il, A. A. ApxHB BeTHayK? 1882, c. 268.
K p a e B C K H 6 A. A. ApxHB BeT. HayK, 1887, KH. II, c. 67.
K p a c H A b H II K 0 B H. A. OIIpeJl,eaHTeab 6aKTepHI1 H aKTHHOMHgeTOB,
M., 1949.
K p a c H 0 B 51. I. BeTepHHapHx, 1946, No 2/3, c. 29.
K p e C T O B H II K 0 B a B. A. K yOIeHIIIO 0 CTaJjHIX pa3BHTHx MHKpoopra-
HH3MOB, M., 1950.
K y a p x B it e B A. A. HccaeuoBaHHe KpOBH C.-X. )KHBOTHHX, M., 1950.
K y A p x w 0 B B. T. 3axalo'leHHe 0 BaKgHHe fIaHKOBa, 1956 (pyxonncb).
K y p H H C. BeT. )KH3nb, 1913, Ne 50, c. 761-762.
JI a B e p a K 9. )KypH. OXOTbI, 1888, I.H. VIII, c. 27.
A a H H K H H A. H. 0 lyMe y necgoB (gnT. no HasaOBy M. 17., 1951).
A a y p CO H A p. BeT. BeCTHHK, 1882, NIN7 3, 4, 5, c. 72-108.
JI e H g. JlecHON )KypHaa, 1837, 1'q 5, c. 320.
JI e n e in H H C K a n O. B. flpoHcxox jeHHe KaeTOK H3 )KHBOrO BeIgeCTBa II
poab )KHBOrO BetueCTBa B opraHll3Me, M., 1950.
JlerlewnHCKax O. CI. H K000poT0Ba M. B.Hayxa11)KH3Hb,1946,
Ns 7, c. 7-11.
JI it H A e H 6 e p r K. BeTBpaq, 1908, Ne 23, c. 357-359.
JI H C H u bI H (D. BeTepHHapHbIH (peabAwep, 1898, NQ 13, c. 65.
JI H C H u b1 H (D. BeTepHHapHbIH r)leabuwep, 1901, N2 8, c. 262.
JI H x a v e B H. B. BeTepHHapHx, 1945, N 11/12, c. 14-17.
J1 o r n H 0 B A. a. Cyab(f)HAHHOTepanHn rlyMbl co6aK, XapbKOB, 1950
(AHcc.).
JI Y K H H M. 3eMaeu. ra3eTa, 1848, Ns 74, c. 590.
JI Y H H H. 9nIl300TH4eCKHe 60ae3HII HJIH CKOTCKHC IlaJIeAKH, 1836.
JI b1 C e H K o T. ;J. BHyTpHBHAOBax KOHKypeHIHII H CCTCCTBCHHbII1 oT6op.
Arpo6HOaorHx. H3A. 5, M., 1950.
J1 bI C C H K O T. Ij. IIpeuncaoBHe K KHHre F. F. Py6HHwTe6Ha flpo611eMa
HaCae,aCTBeHHOCTH npH Ty6epKyae3e, M., 1951.
JI Io 6 a in e H K 0 C. 9. BbICTynaeHHe no Aoxaaay E. C. Llepxaccxoro. ITpo-
TOKOa COBeLLI HH5 B BeTOTAeae F.n. ynp. norpaHB06CK, XI-1948 (pyKonHeb).
Ji 10 6 a in e H K 0 C. 9. J1enTOCnHp03bl }KHBOTHbIX, M., 1950.
JI K) 6 a in e H K 0 C. 51. (peA.) Boae3HII nyIHHbIX 3Bepeil, M., 1952.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
110 6 a HI e H K 0 C. 51. B KH. BLIuICJ1CCCKa13 it (D. A. TepCHTbeB (1956, pyKOHI!Cb).
M a H T C P tp e Jl b Il. A. Co6o,nb, M., 1934.
M a H T e Ii (p e Jt b H. A. 0 iyMe y KONOTOB, 1951 (JIn9H. coo6m.).
T.; a p it H. H. BCT. o603peH"e, 1899, T. 1, c. 663-665; 1900, T. 11, C.
837---839.
Al a p r y .n it e Al. C. H Ap. 1lt'MneJIHHH3HpyKxune 9Hu4a.noMneJIHTbI, M.,
1947.
M a c n e H Il It K o 13 a 0. H. Cos. BeTepaaapnn, 1934, N 8, c. 70.
M a It Y A e B 11 1 K. H3MeHCI;IIA CHHHHoro M03ra HPH 3 'Me C06aK, CllB,
1883 (mice.).
M. B. F. CO63K013OACT13O, 1932, No 10, c. 11.
M c A B ea C B 1'. H. BOeaHble Co6aKH B Be.n. OTe'IeCTB. BOFHe, 1953 (pyK.).
M c T U JI K n H A. H. H C a x a p o B H. H. HH(PeKuHOIIIIble H aHBa3HOHHbie
60.1031111 Kp0.31KBB, M., 1940.
M C T e.1 K H H A. H. Kotmiu HHHble HHBa311n KpoJiaKa, M., 1944 (AOKT.
a I I cc.) .
M e11 H H K 0 B H. H. HCB0CIIpHI1M1J1I13OCTb B HH4ICKIIIIOHHbIX 6oJIe3I3AX, M.,
1947.
Al C LU C p C K H H A. BeT. tpe.nbal1Tep, 1907, Na 5, c. 155, Na 6, c. 189.
M it Ti e H Y HI K H 11 10. H. llpxpoAa, 1947, N9 3, c. 29.
M it p o n to 6 0 B H. Co1o311ywaaaa, 1932, N XV, XVI, c. 36-38.
M H x a H A o B B. C. hOJIbuuan co6aKa, M., 1903.
M H x a P i o B B. C. OxoTHHK, 1926, Na 10, c. 16.
M B x a iirn 0 B B. C. Co6axoBOacTBO if ApeccnpoBKa, 1926, N9 5, c. 15.
Mu x a P n O B B. C. YXOA 3a 3AOpOB019 it 6o.IbHOH co6aKON H HejBafl 110-
MOIUB np11 3a60JICBaHHH, M., 1928.
M it x a 0 JI O B B. C. Co6aKOBOucTBO H ApeccapoBKa, 1928, Na 1, c. 14.
M H X a 11 .1 0 B B. C. boJIe3HH Co6aK (peylaKTOpCKne np11Me'IaHHH H KH.
KaAHO n bpeTOaa bOJIC3HH co6aK), M., 1937.
M o :3 FO B H. E. (DapMaK000r11bI, 1955.
M 0 111 IK 0B c K H H UJ. J. Ycnexn COBpeMCHHOH 6ao.noran, 1945, T. XIX,
B. 1, c. 1-44.
Mo III KO BCKn H III. J. HOB. MeA., 1948, B. X, c. 57.
My P o n1 u e a C. H. flony}Ka.KHe BaKUHHbl, M., 1944.
M y p O M u e a C. H. BeTepnaapasl, Na 9, 1948, c. 18.
M y p O M u e B C. H. >Kypa. oOtue0 0o.aoran, 1951, T. XII, Na 3, c. 161.
M y p 0 M u e a C. H. H3MPHtIHBOCTb MHKpoopraHn3MoB H HpO6JIeMBI HMMy-
HnTeTa, M., 1955.
M Io JI JI e p 1'. L0JIe3HH co6aK, BHTe6CK, 1928.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
H a 3 a p o B B. II. BeTepBHapnB, 1954. Ne 9, c. 38-41.
H a 3 a p o B B. 11. 3axnlovellHe 0 BaxuHHe Ilanxoaa, 1956 (pyKOnHCb).
H a 3 a p o B B. 11. H Po m a H o B A. M. HMMyHH3aUHA npH 4yMe co6ai,
1940 (pyxonHCb).
H a p C K H H B. Co6aKOBOACTB0 H j peccHpoBKa, 1927, Ne 11, c. 13; Ne 14,
c. 18; Ns 16, c. 9.
H a p C K Ii ii B. C06aKOBOACTB0 H ApcecHpoBKa, 1928, Ng 11-12, c. 6.
H a p C K H H B. BecTH. cOBp. BeTepHHapHH, 1928, NQ 10, c. 313.
H a Y M 0 B I-I. 11. 0 KAHKOBaHua (UIIT. no A. H. c1opM030By- Kone6aHHA
tHc.7emIOCTH npOMbICJIOBbIX ?(HBOTHbIX, 1935).
H a Y M 0 B C. 11. 3oonorun n03BOHOgHbIX, Al., 1951.
H e M It 0 B A. CO6aKOBOJ(CTB0 H ApeccnpoBKa, 1927, Ns 11--12, c. 18.
H e m U o B A. Co6aKOBORCTBO, 1933, No 1, c. 20.
HecTepeIf Ko B. M. BeTepHHapHH, 1953, Ns 5, c. 26.
H H K H (p 0 p 0 B H. H. BeTepnnapHwii 'cpenbAUiep, 1898, c. 232.
H H K 0 JI n b 111. 3BOnx)UHH 3apa3HbIX 60ne3Heii, 1937 (nep.).
H H K 0 n b C K Ii Fi F. E. 0 t:bx H 0o'-tc,HAx . ;,ttH
HHx KHBOTIIbix, CHIT., 1866.
P a A 3HB H.9 a o li c Kit N F. fl., At pii iCKKItii 11. Al. it Tip. III I;5Ka
344eKTHBIIOCTH B1KI1HH 4VMKi co6aK, 19.31, 1932 (pl'h:)HnCb).
P aA 3I1BHaa O BCKIIN I'. n. Coit. Bc.cpHHapnst, 1933, A_= 11, c. 53;
1934, Ni 8, c. 64-69.
P c 6 p o B H. 14. bypilT-MOHI. ncr. Hn-T, TI;yAbi, Bb[n. 1, 19'19, V,ir 1.
c. 30-37 H M., 1936_ (ABTOpe(pepaT).
P e B o Al. B. I-pyAbi 2 cbe3Aa Hai if 11paK111 1, BeTpalornHrols ,H r,i,B,I
gm, Xapi,KOB, 1927.
P c H T e p. I1yMa co6aK B CB513H C apyriinni ~IHOTO BCTPCVaml ItMIi ;t v 111tH
60ac31InMII, XapbKOB, 1892 (nep.).
Pe3oalouHA itHV~IHO-TCXIIn4CKOI'O COBCIIIiI111L`I 1911 F.TanuOM 11.'i C1,l1!lalIIoi
ynpaBaoHIIhi I-1apK0M3cMa CCCP no AoK~taay F. C. yeOHHCCKOFO. B) 172
L1eM1ieJI11H113I1pyIouuIi'i )H Uecpa.'IIIT IIJIH rxnepxepa1io3 Jlan (oKCCTKan
Jlana>)
ISeIDeHCTBO 173
boJIe3Hb AyccKli (HceBgo6eu c1iCTBO) 174
KaM laTCKa;I ;(HKoci,b co6aK n nCCUOB H ApyrHX 3Be1CH -
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MH4)eKIUHOHHa5 6pOHXOHHeBMOHHH 175
HH(peKI HOHHbIii 3HUocl)aJ10MH3J1HT nJIOrOHAHbIX (HH((eKUH0HHb1H rena-
THT co6aK) 176
FHnepKHHe3HB 177
1' 1H(l)eKUHOHHb1}i KepaTHT 178
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U1TyTrapACKaSI 60Jie3Hb HJIH TH(? CO6aK
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ToKCOnJIa3MO3 180
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TOH3HJIJIHT -
1'eJIbMHHT03bi -
ABHTaMHHO3bl 182
I'1CTepHH co6aK (60JIe3Hb PaiTa). -
3nHJlencnx H 9KJIaMncxSI -
TJIABA TPHHA aUATAS1- AKTHBHaSI HMMYHH3a1UHH npH 9yMe nJIOTO-
SIAHbIx 183
1F HCTOPIIH Boripoca 184
flepxoA BapnoJIHUHH (npHBHBKH BHPyCOM BaKLUHHbl) -
flepnou HHOKYJISIUHH (HPHBHBKH BHpyneHTHOrO MaTepnaJla) 185
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BaKUHHaUBB co6onei -
BaKUHHaI(HSI ApyrHw nnJIOTOAAIlbIx -
280
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FJIABA 4ETbIPHAAUATAS1 - CneUH4)HVecKasi cepoTepanl6 H ceponpo-
4IHJIaKTHKa 9yMbi HJIOTO$IAHbIX 224
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pOTKH 242
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FJIABA HS1THAj1L[ATASI - BaK11HHOTepanHsl 246
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JleHe6Hb1e 11PHBHBKH BHpyCHbIMH BaKI(HHaMH 247
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CTpa-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
4Ie6ofCcapcxas Txnorpa4)xa N6 1
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Uena 10 py6 50 Icon.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
V EBHHI{H H YLIEBHbIE HOCOBHH AJIH BbICIIIHX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Om aemopa
B aTOM noco6HH BOHPOCM o61geH BeTepHHapiioH xHpyprHH OCBe-
njeHhx B COOTBeTCTBHH C npOrpaMMOH Ang BJICHIHX BOTepHHapHSIX
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npOgeCCOB H Cnoco6aM TepanHH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BBEJ'EHHE
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72
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MOHTaMH BeelI CHCTCMbI 3aMHTbI, H HOTOPbIM OTHOCHTCH COCyWIICTble
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
IipoI;eccbt, evitoitHbie H paefpOCTpaHeHHlo. ttaToreHHble CBOIICTBa
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172
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
H yMeHbIIJCHHe 6oJIe3HeHHOCTIl; paccrIa6JTeHne THaxebl 11 I'JlYIlfn0HHe
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CHJI1HBIH pa3ApaWFITeJlb. 9THM ycyry6JI IOTCFI paCCTpOHCTBa I*eHTpaJIt-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
yTOJIH;eHHble BOJIOCbt IIP1 HaL aBJIHBaHHI3 CHapyaXH pa3JjpamalOT C1300
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ogaron HarnoeHHH ~ypynnyJie3 nplO6peTaeT xapaHTep ynopnoro
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
iJIe6HTa. B HocJleonepanxnolHbllE Ileplog, 90 MoMOHTa yCTOiigHBOro
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xHamne HJIeTLIaTHa H IIoBepxnoCTHaH C 1acgnfi.
2. PacmHpeHHe H yrJIy6aaeHHe npoi ecca conpoBo7HAaeTCS B 6oJIb-
moM LIHCJIe CJIyLIaeB uopa?HeIineM nnM(aTHTIecHHx H BCH0311bIX COCYAOB
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oprauu3Me, xapaHTepubIMH AJIII TFI?HeJIOi3 rn0IHOE3 HII eOEAHH (yrHOTeHlle
?ICHBOTHOro, iOBbHHeHHO TeMIIepaTypbE TejIa, rnnepJIeIIH0AHT03 HAP.).
4. THaHeBOiI Ae(eHT, Bo3HHHaIoigHu B pe3yJTJTaTe pacnaAa HofHH
upH Hap6yHxyJle, AOCTHraeT Asyx-Tpex caHTHMCTpOB B AnaMCTpe.
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CJIeAyIOHI OM, B Te1IeHHe 9JIHTeJlbnor0 CYII;CCTBOBalIHfl MaCCHBHOrO
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(f ypyHHynie. B CnyLIae 6ypHoro HapacTauu i BocnannHTeJIbllbix gBJIe-
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par noHaJleH HpOCTOO6pa3Hbiil pa3pe3 Ha BCIO rJIy6HHy nHCJIHJIbTpaIkHH
TEHaHeH. Ero AOIIOJIHIIIOT C IWOJIblO III14POIHOr0 BCEHPbIT1H rHOHHOTO
oLIara FOPH30HTaJIbHbIMH pa3pe3aMH AJIH OTCOnap1POBaHHH HpaeB
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?HeHHeM OTCaChIBaIOH~eH IIOB}I31H. B IIOCJIe0IIepaI;HOHHbIF nepHOA,
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pOBaHHH paHeBOiI IIOBepxnocTH, npHMenflOTC}I CyJlbd)annJIaMIIAHau H
neHHELHJIJIHHOBafI (coLleTaJIHaT) Tepanus. B AaJlbnel3HleM JIegaT
rpaHyJEHpyiomyio parry.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ABCAECC
A6ci(ecc (abscessus), HnH HapbIB, - BocnarnHTeJIbHblg upon ecc,
conpoBO?ic aIou nncn o6paaoBaHHeM IIOJIOCTH, HanOJHeHHOH rHOeM
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06bI4HO HeBeiiHnH; B pbiXnbIX MNIIIIegHIIX IInaCTaX H B IIOJjIOH(HOII
nneTYaTne, oco6eHHO B ygaCTnax Tena, rjje Kona IIIHPOKO IIOABH)KHa,
OHH Hepei no OCTHraIOT OTiOHB 60nbIIIHX paaMepoB.
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pHOMHK03, Ty6epnyne3). Ha anccygaTa a6CI(e00OB cpaBHHTenbHO
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u ue HX pa3BHTHIO H B03HHKHOBeHHIO o`Iara IiarxoeHHH, Ype3B1EliIauHo
pa3HO06pa3Hbl. A6cijeccbi MOrYT Bo3HHKaTb: B paH0BbIX IIOJIOCTHX,
iiarJIyxo aanp1ITbIX IIIBaMH IIpH HeJjoOTaTo'inoiI x1pyprHLIednoI o6pa-
60Tne H HeIIOJIHOM cMbinaHHH paxeBOr H;e1H B rJIy6HHe; B KaHanax
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CTOBaHHu, Tannie CollpoBon ae.TCH a6CA0AHpOBaHHeM.
B pannHn IIepHOJj BBIIIOTeBaHHH anccygaTa H CKOIIneHHH ero
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CTeneuu JIHxopaJjna, yaauleHHe IIyabca, neunOIIHT03.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
1103H{e, I; LJOTBepTOMV-MOCTOMy AHIO, B HJIHIIH'IeCI;Oii BapTnHe
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ona 6oJiee 9OTHO HOHTypnpyOTCH Henocpe)jCTBeHHO Ha yponae (Iolyca
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CTaIOIuIJxCH rpanyJlxrrIIH H H HOCTCIIeHHOMy yTOJIWeHHIO cTeHBII
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B Ba'ecTBe OPIIOHTIIpOB IIpH C03J[amm AOCTyna H rnoIIHOIT IIOJIOCTH).
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o6J.Iagaionj4x AOcTaToiIHOH yCTOH9HBOCTbIO, HpOpblBalOTCH McJ[JIeHHO A
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HHOrga OHH B c)opMe OCyMHOBaHHbiX IIOJIOCTeI3 OCTaIOTCH B THaHHX
Ha BCTO 3KI33Hb; TaiHe cnIytlaH TIame Ha6JIIo) aIOTCH y HpyHHOro pora-
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OTMegaeTCH Y H HBOTHNIX BCex B1AOB, HorJ;a a6CIlecc o6pa3yeTCH
B rJTy60KIIX IIJTaCTaX MaCCIIBHtIX MNIMA, II0Z[6pI01IIHHH0 HJIH B TOJICTMIX
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rHOI3HOLI IICJIOCTn. IIn0reHHaJ o6ojiotIKa, yToJIIgagcb IT CTaHOBHCb
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O6C3BpCH HBaIOTCH 11 TepsIOT CIIO006HOCTb K pa3MHo?KeHnIO. C Te-
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CymeCTBOBaHIIH 3aHpIITOIT IIOJIOCTII - TBOpO}KIICTMM, TITO 06yCJIOBJIH-
BaeTCH BNIIageHIIeM KpHCTaJIJIOB Conn npH OAHOBpeMOHHOM BCaCbIBa-
IIIIn ?KlJ;KHX 3JIeMeHTOB co epmHMOro IIOJIOCTT.
IIpI HaJTIILIHH B THaHHx OCyMKOBaHHbIX OLIaroB HarHoeHIIH ICJIHHH-
TIecime HBJIen1H 6bIBaIOT ciia6o BbipaHfenbT. TeMnepaTypa Teiia, nyJIbC'
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o HaHo, BMICOKIIX rpaHnA.
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OnepalYnOHHbIn nepHog IIp1MeHHIOT TO He cpeAcTBa, qTO II IIpH rpa-
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6ypnoro BocnajIeHHH II pacnaAa TKanef, xopomne pe3yJIbTaTbI MOryT
gaTb nyHKI[is, OTCacbIBaHHe coAep? c oro HOJIOCTH II nocneJ;yioii ee
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IIOCJIe nOBTOpimiX BJIHBaHHl H 0TcaCbIBaHn1T pacTBopa cTpenTogHga
B HOJTOCTb BBO,jHT paCTBOp IIeHII9IIJTJIHHa. IIpn 3TOM JierTle H36elIaTb
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HeyAaq, O6yCJIOBJIOHHLIX yCTOHLIHBOCTbIO K TOMY HJIH IIHOMY IIpeIIapaTy
MHHPO6OB, yLIaCTBYIOMFIX B pa3BHTHH IIpoIrecca. Hpi Heo6xOAHMOCTH
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HOJIHgOCTBO HOJIOHIIII. B CJIyTIae CMemaHHOII IIH(JeICIuHH CHaLIaJIa o6bILIHO
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MOCTbIO TicaHel, B03HHHalolruIx 06bIiIHO B pe3YJlbTaTe TpaBMaTHLIe-
CKHX IIOBpen{AeHIIH. B Ka'IeCTBe ocJiO}KHeHHn ee Ha6JiioAaIOT IIpi rHOH-
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CYXO}HIIJIbHbIX BJIaraJH4JI H CyMOK, KOCTHOrO M03ra H T. A. TH}neJian
riy6onan ()JIerMOHa, Han IIpaBIIJIO, COIIpOBomgaeT nep()opaimm: imige-
BoAa npi o6Typal[HH IIHOpOAHbMMH TeJIaMH, a TaK}He paneHHFi ero
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onepaTHBHbIMH BMemaTeJIbCTBaMH npH (ypyHKyJlax, a6cIIeccax II
B ApyrHx cJiytIaHX rnoTHOI3 HH(J)CHILI'I BcerAa CyMeCTByeT yrpo3a
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cJIa6o HpoqBileHLI npH rJIy6oico Me? fMSIIilegHo} ~3IerMOHe, gem 13 3Ha=
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CTH HOTOphIX IIpOHCXOAHT rpaHyaHpoBaHHe. Taicoi3 IIpouecc HMeHyioT
a 6 c ix e A H P 0 B a H H e M. HJIHHW ecHafl KapTHHa B COIIOCTaBJIe-
HHH C HaTIaJIbHNIMH HBJIOHIIHMH HeCKOJIbKO H3MeHHeTCH: yMeHhJ laeTCH
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CB11 eTeJIbCTByeT o6 oCJI0HCH0HIIIHX ee. B ux TIHciTc HaiCoriee TIaCT6
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(HepH(JIe6I1T) C 1IOCJIOAYIOII14M BoBJIOMOIIIIeM B IIPOIWCC OcTaJlbHbIx
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6HpoBaHnH JIC?ICHT paaJjpaalceHne nHTepOpeuelITOpOB COCyj>;IICTOLI CTeHICH
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
noBuIIHeHHe gyBCTBJTeJIbHOCTf 3HJAOTeJIlR), a TaK1Ke n3MeHeH}H CO
CTOPOHbI HPOB1 cencn6HJln3HpoBaHHoro opraHu3Ma.
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(pHC. 59).
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rnoeM. Tonibno B MeCTax, rge cTeuI{a BeHLI 6OJIee o6HJIbHO CHa6xceHa
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cocygaMH, oe'raIOTCH ee TIOCHyTLI, cJIHBaIOIIwec5i c HJlaCT0M rpaHyangiaii,
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apTepnaJlbxblx II IIepBHLIX CTBOJIOB, HepeAiio H pa3BHTITIO o61gelI
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BO3MO}HHbI Hpn TpoM6oc JIe6HTe B o6JIacTHX TeJIa, He JLOCTYHHMX
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HpH (JIe6HTe B HerHOMHOM TpoM6o(JIe6HTe, a TaH}He B HaganbxoH
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MIIIrpO6bl, To1CH'IeCKHe npOJIy1TbI HX ali143HeAenTeJlbnoCTn, HpOAyHTbi
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
raHH3M rJIaBHnIM 06pa3oM TOHCHHOB, IIOCTOHHHO IIOCTyfaIOIIj1X
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8? 211
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
raHH3Ma, noxa 6oJIee HJIH Meaee yCTOIIqHBO He paccTpaHBaIOTCS ( )yHK-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80TOO246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TepHi3, OTCyTCTBHO aHaCTOMO3OB B OIIpeAeneHHbix opraHax H TxaHHX
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
A,JIFI yTOLIHOHHf HOCMepTHOrO J[HarH03a npH6eraIOT H 6aHTepno-
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inofi gaCTOTbI ny mca OTHOCHTeJIbHO MaJIO IIOBbIIHOHHOII TeMIIepaType).
rJiy6oHHe II3MCHOHIIH yCTanaBJlnBaloTCH B 1pOB14: rHnepJIefiNo-
I111T03, CAB1r BJIeBO, yMelbIIIelne 1OJIH9eCTBa 3PHTPOAHTOB H re-
Mor.Io6nla, yBOJIIIT CHHe 1OJIIIileCTBa rpy6oAHCnepCHLIx 6CJIHOB (rJIo-
6yJIIIHbl, f 16pHIIOreH), yCHOpeHIIO peaHU I11 OCOAaH11H apHTpOljnTOB.
(Heo6xoAHMO, OAHaHO, OTMOTIITb, 'ITO B 60JIee n03AHHO 11ep1OAbI cen-
CIIca, B CBH3II C rJly6oli4MH ( )yHHIjnOHaJIbHbIMH paCCTpOHCTBaMII
H 10AaBJIeHHOM San uTHbIX CHJI OpraHn3Ma, LIaCTO HaCTylaeT CJia6o
BMpa?HeHHbIII 1T0 HOIAHTO3. 3THM AOBOJIbHO XOpOI10 HJIJIIOCTplipyeTCH
IIpeACTaBJIeHHe 0 Tau Ha3bMBaeMoii alOprHUeCHoii 4opMe ce1CIICa.)
O6bITIHo HaXOAHT yBOJIHLIeHHbIMIl B 06'beMe IIenellb 11 ceJle3eHHy.
B MOLIe o6Hapy?KIIBaIOT 6eJioIC, EJICTOLIHbIC 3JIOMOHTbI HpOBH, I[HJIIIHApbI.
LIaCTO BO3HnHaeT OJIHrypiIH.
CO CTOpOHbI AHa rJIa3a y?ICe AJIH paHHeii CTaAHII THwOJiOPO CeII-
cnca XapanTepHbI rnnepeMHH coma 3pHTeJIbHoro HepBa, IIepenoJIHeHHe
COCyAOB COTUaTI{II (CHCTeMa IjeHTparIbHOH peTHHarIbHOH apTeplilf),
II3MOHOHHO OTTCHHOB tapetum lucidum c IIOHBJIeHIICM Ha HCM TOMHO-
I IIOJIOTOBbIx IIHTCH H IIOJIOC, o IaroBal 06JIa'HOCTb (CepoBaTble, c ro-
JIy6MM OTTeJIHOM yilaCTHn) B OHpy?HIIOCTII coma 3pIITeJIbHOPO HepBa.
1103?He COCOR aTpO()npyeTCH, OH CTaHOBIITCH aIOMngHbIM (B. H. ,e-
MIiAOHHO).
TIpII McTaCTa3npyIOIIjeH IIIII OHIjnn, BBIIAy nOHBnelilf OMarOB
HarnoeHHH, pallblle HJIH 1103?HC OIIpeAeJIHIOTCH CIIMIITOMUI, CBOH-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CTBeHHbie COOTBOTCTByIOIIXHM IIpot eccaM: naeBMOHHH, Hef pgTy, re-
IIaTHTy, apTpHTaM H T. A.
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IIHHX )yHKI;HI3 opraHOB rrnn esapeHHH (ceHpeIZxH, HepesapHMocTH
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IIpH3HaKOM. IIoHOC - ono H3 HBJIeHHH A e H O M II e H C a g H H.
K 3TOH me rpyIIIIe CHMIITOMOB IIpHLIHCJIHIOT: HapyIIIeHHe pUTMa cepJu a
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30%; ycToH uBOe IIa)eHHe yj[e.lbHoro Beca MOH go 1,010 H HHH{e,
KaH IIOKa3aTeJIb paCCTpOHCTBa ( HJIbTpaIUHOHHOH CIIOCO6HOCTH IIOgeR;
aTpo( )HIO HOMOHH C COIIyTCTByIOHJeI3 eft HfeJITyxoI3; acr HT, IIporpeccH-
pylolgee HCToueHHe H Ap.
C pa3BHTHOM cencHCa OTLIeTJIHBO H3MeHHeTCH COCTOHHHe IIepBHg-
Horo oMara. FpaHyJIHIIHOHHa5 TKaHb HOKpbIBaeTCH HaHIeTOM; Me-
CTAMH pacnaAaIOTCH rpaHyJIHIIHH H OPOJIHIOTCH no JIe?KamHe TKaHH;
3KCCygaT OTAejIHeTCH B OPpaHHMOHHOM KOJIHgeCTBe, OH CTaHOBHTCH
rpJ3HbIM, 6ypoBaTbIM; HepeuKo Ha6JIIo)aeTCH apPO3HOHHOe KpOBOTe-
geHHe.
go pa3BHTHH j[eHOMHeHcaIJHH OCHOBHOH BOIIpOC gH44epeHlUHaJIb-
110i3 AHaPHOCTHKH BO MHOPHX OTHOIIIeHHHX BLIHCHHOTCH B IIepBbie AHH
node OIIOpaTHBHOPO BMemaTeJIbCTBa. KaK H3BeCTHO, gOCTaTOgHoe
BCKpbITHe OLIara HH(eHI;HH, yAaJIeHHe OMepTBOBaIOH;HX TKaHej, Ape-
HHPOBaHHO H pyre MeponpHHTHH, HanpaBJIeHHLIO K orpaHHLIeHHIo
BcaCNIBaHHH TOKCHgeCKHX BeII;eCTB H3 yLIacTKa nopaaceHHH, AaIOT
yx(e Ha BTOpOH AOHb XOpoIIIO B1IpaSKeHHLIH TepaIIeBTHLIecKHH 3t 4eHT.
Y ceIITHwcHHX 6OJIbHbIX TalHe BMeIIIaTeJIbcTBa JIIIIIIb IIpH OAHOBpe-
MOHHO yCHJIOHHOM IIpIMOHeHHH IIpOTHBOMHKp06HbIX CpeACTB H TOJIbIO
K 3-5-My AHIO IIOCJIe onepaqHH cIa3LIBaIOTCH, H TO He BcerAa, HeKo-
TOpbIM y3IyMIIIeHHOM COCTOHHHH 6oJIbHOrO. Bo MHOPHX cJlygaax cyllXe-
CTBOHHbiX H3MeHeHHH B TegeHHI3 Ce1CHCa He Ha6JIIOAaeTCH game nocae
IIOJIHoro yAajieHHH IIepBHMHOPO oqara, HaIIpHMep aMIT TagHH HopaHLeH-
HOH KOHegHOCTH; HepeAKO onepaI[HOHHaH TpaBMa BJIegeT 3a co6ox
yrJIy6JIeHHe CeIITHgecKoro COCTOHHHH.
B TeMHepaTypHOH peaHgmi y JIoIIIaAeii IIpH o6IgeI3 PHOHHOH HH-
( eKI;HH C McTaCTa3aM'H H B OCTPOM nepHOAe HH1)eII;HOHHOH aleMHH
HMOOTCH HeKOTOpoe CXOACTBO. ,Jiff AH(gepeHIJHauHH 3THX 3a6oJIe-
BaHHI3 Heo6XoAHMhI cnegHaJIbIIble HCCJIeAOBaHHH (B KOHC HOM HTOre -
6HoJIOrHgecxaH Hpo6a, Kai HaH6oJlee HaAeaHMIH McTOA AHarHOCTHKH
IMAH). YTOMHCHH1IH AHarHO3 cencHca c BLIHCneHIIeM xapaiTepa
B036yAHTejiH O6eCHeMHBaIOT IIOCeBLI Hpo6 KpoBH 6oJlbxoro MHBOT-
HorO Ha IIHTaTeJlbabzx epeAax (reMoiyJIbTypa).
IIpH HaJIHMHH IIepBHgxoro oqara, CJIyxean ero BXO HLIMH BopoTaMH
AJIH MHKp060B H IIoJIeM BcacblBanln TolCHHOB, eMy yAeJIHIOT AoJIaHoe
BHIIMaHHe: pacfHpRIOT pa3peaaMH rHOIIHLIe KapMaHLI; yAa:IHIOT
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
McPTBLIO TKaHH, IIHopoAHIle Teala, oMbIBaeMble rHOeM JIIIraTyplt; HyTeM
TIIAaTeJlbxorO Z[peHIIPOBaIII3II o6eCIIeiiHBaIOT OTTOR 3Rccyj[aTa; B rHOI3-
Hble IIOJIOCTII BBOJXHT CTpelTOI UA, IIeHIiuLJIJIHH IIJIII IIX CMecb, rpa-
MHuHgHH H p(pynie IIpOTHBOMIIHpo6Hble BemeCTBa. BceMepno Ro6H-
BaIOTCH HMM061uIH3agHH uopaH{eHHOro LIJIeHa. Bee 3TH MepOHpfiTIIH
BLIHOJIHHIOT H IIpf IIOHBJIeHIIH BTOPIInHbIX OqaroB HarHoeHrii, AO-
CTyIIHbIX OIIepaTIIBHOMY BMemaTeJIbCTBy.
Ba?KHeAmefi 3aj[aqeI3 TepaIIIIH HBJIHeTCH oxpaHeHge OT IIepepa3?-
Apax{eHHH ueHTpaJIbHOH HepBHOII ClCTeMbI. C 3TOII IkeJIMO Ha3Ha*IaIOT
CHHPT, MamIble J[o3bi xJIOpaJIrflJlpaTa IIJIII coueTaIOT BBeAeHHe o6onx
3TIIx BeIueCTB (BHyTpb, peRTaJlbxo, BHyTpuBeHHO).
iIIpOKO IICIIOJIb3yIOT CyJIb(aH1JIaMI4gbI H IIOHIIu1JIJIIIH. B IIepnopt
eeHcH6IIJIII3auIIII cjIeAyeT BO3gep?HIIBaTbCH OT MHOroRpaTHbIX (IIOBTOp-
HbIX) BHyTPIIBeHHbIx BJIIIBauhII3 Rau HepeLIHCJIeHIIbIX, TaH II gpyrHx
BeIueeTB. Ho3TOMy ueJIecoo6pa3HO 3agaBaTb cyJlb( aHmiamil;XHble IIpe-
napaTbl BHyTpb, OCTaBJIHH BHyTpHBeIIHLII3 II BHyTp1ITHaHHbIII HyTH
AJIH BBeReHHH IIeHHIXH IJIHHa.
B Ha-IaRbHyIO cTaJjuio ceucuca HeO6XORi3Mo Mo6IIJIII3OBaTb HMMyH-
Hble CIIOCO6HOCTII OpraHll3Ma, IICIIOJIb3y$ cpejcTBa TepanHH pa3Apa-
?KeHIIeM. K TaRHM CIIoco6aM OTHOCHTCH: nepeJInBaime He6OJIbIIII1X
AO3 KpoBII, ayToreMOTepannn, IIpOTeHHOTeparma. a3TII cnocO6bI nO-
BbIIHeHHH peaHTHBHOCTU opraHn3Ma 34 4 eETIIBHbI Tai{?Ke IIpt XPOHII-
LIecHOM TCxICHHII cencnca.
PaCCTPOIICTBa CepRe'IHO-000y) HCTOII CIICTeMLI, 4(IyHHIUHH HOWIeu
H IIewHII, 06yCJIOBJICHHLIe lOBbIIIIeHneM HPOHIIuaCMOCTII 6HO:Iori!gecuux
McM6paH, Tpe6yIOT McTOj[HLIecHOrO IIpIIMeHeHIIH XJIOpuCTOI'O KaJIbIHH
(BHyTpb, BHyTpUBOHHO), ypoTpouuua (BHyTpuBeHHO), Ko4 enna.
ilpH Cencnce 6oJIbmyio porn HrpaeT IIOJIHOuenHoe i{OpMJIeHIIe.
KopMa AOJI?KHbl 6NITb Jieri{O nepeBapuMbIMH, C ) OCTaTOLIHMM co ep?Ka-
HHeM BIITaMIIHOB A, B H C (3eJIeHas TpaBa, upopaIueHHLIH HTIMeHb,
KOPHeIIJIOJ{hI, IIIIIeHIILIHble OTpy6H). Korga ?KIIBOTHOe HeOXOTHO HpH-
HIIMaeT KOPM, BJIHBaIOT rrIIOK03y BHyTPIIBeHHO IIJIII peRTaJIbHO.
K KopMy JZo6aBJIHIOT caxap IIJTII naTOl{y.
BOJIbHOMy H{HBOTHOMy Hpej(OCTaBJIHIOT IIOKOH B IIPOCTOPHOM IIO-
MclueHnn. H O6IIJIbHyIO MHPKYIO IIORCTIIJIKy BO II36eH{aHIIe npo ieu{Hen.
C yJiyiIIIIeHueM ero COCTOHHIIH (geceHCH6HJI113aiHH) Ha3HagalOT Ilpo-
BOgKII; B XopoIIIylo, He ?Kapuyio norogy x{IIBOTHOe BbJHycKaIOT Ha
IIaCT6Hlue.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
rJISBA VIII
AHA3POBHAH H I'HHJIOCTHAH HHOERI1HB
AHA3POBHAH HHQ>ERIXHA
Boa6ygIITema
AHaapo6Han HH4IeHIIHR OTHOCHTCH H 'IHCJIy *Ipeasbll1aMHO TRHfeJlbix
ocJIO?HHeHH33 paH. CpeAH Bo36yAHTeJIeI3, o6yciIoBJIHBaIollKHx ee paaBH-
THe, oco6o Ba?EHoe McCTO aaHHMaeT Ta} Ha3binaeMan rpyIIIIa geTmpex
(A. B. McJIbHHHOB): Clostridium perfringens, Cl. oedematiens,
C1. histolyticum, Vibrion septique; a Taixce Cl. sordelli, Cl. fallax,
C1. carnis H up. HccnnegoBaHHSI M. P. HegaeBcxoi (1951) gaioT ocHoBa-
HHSI npHgHCJIHTb cio a me paHee HeH3BeCTHbIH Bac. gangraenae rubrae.
B accoIInaIIHH C yIIOMfIHyTbIMH MHHpo6aMH npH aHaapo6HoU HH-
11eHIIHH 'iaCTO BCTpe gaIOTCR upeAOTaBHTenIH rHHJIOCTHOH aaaapo6HoH
rpynnbl (Streptoc. anaerobius, Str. putridus, Str. parvus, Bact.
proteus vulgare), rHoeporwBIe MHHpo6bl, HeHpo6agHJIJIb!, canpo(HTbi.
B3aHMOBJIHRHHe MHHpo6oB B accollHallHRX BO MHOrHx cnIygaRx
cHa3I,IBaeTCR ycHnenneM naToreHHoro jIeHCTBHR OCHOBHOTO B036yj(H-
TeJIR npoilecca. B HaLIeCTBe HJIJIIOCTpaIjHH MOM HO npHBOCTH 3HagH-
TOJIbHOe napacTanne naToreHHOCTH Cl. perfringens B accoIlnai nn
c rnoepOjjHLIMH CTpeIITOHOHHaMH H cTa4IInononnaMH, C CeHHOH IIaJioH-
HoH, capIIHHaMH.
CIIoco6HOCT1b IIpOHHHaTb B rny6HHy THaHeH oCo6eHHO Bbipaxcena
y Cl. perfringens BCJIejICTBHe BblAeneHHR HM rnanIypOHHjxa3bi. 3TOT
MHHpo6 yxce B Te'qeHHe nepnoro *Iaca nocne paneuHR HHorjla o6Ha-
py?HHBaeTCH Ha paceTORHHH AeCRTHOB caHTHMeTpoB OT otiara nopa-
?HeHHR. Hapiu y c 6OJibmoH CHJIOH ToxcnHoo6pa3onaHHR OH o611aj(aeT
caxaponHTHilecHHMH, reMOJIHTHqeCTHM1 H HexpoTH3HpyIOHwHMH CBOH-
CTBaMH C o6pa30BaHHeM ra3OB.
HecnoabHO MejjneHHee Bblpa6amIBaloT TOHCHHhI j(pyrne npe--
CTaBHTe IH rpynnbi naToreHHbix anaapo6oB. Cl. oedematiens CBOH-
CTBOHHO pa3BHTHe OTeia B HJIOT'IaTHe, B Mi.IIIIIIax c reMOJIH3oM H
pacnaAoM THaHeH 6e3 o6pa3OBaHHR ra30B. Tame OTCyTCTByIOT
ram npH pa3BHTHH B THaHRX Cl. histoliticuim. Ero *ipe3BLIqafHo
cnmlbHbie HeHpoTH3npyIOHIHe cBOHCTBa o6yCJIOBJIeHbI o6pa3onaHHeM
( H6pHHOJIH3HHa. ' 3TOT ( epMOHT paCIInIaBJIReT TH8HH B OTCyTCTBHO
HJIH IIpH orpaHHileHHon CTeneHH oTexa. Vibrion septique (B. oede-
matis maligni) H conoczanneuHH c Cl. perfringens o6aaAaeT Menbmen
217,
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CIIO006HOCTbIO ra3oo6pa3OBaHHfl. CnmIbi ero caxapOJIHTHtIecrHX H
reMOJIHTHgecIJX (epMeHTOB, HeHpOTn311pyIOll ee AelCTBHe H TOR-
CHLIHOCTb HPOAyRTOB HfH3HeAegTeJlbHOCTH otieHb BeJIHHH.
IIaTOrelHbie alla3po6bI - IIOCTOfIHHTIO o6HTaTeJIH HnmegHHKa HfH-
BOTHbIX It tiejIOBeHa. B npnpoAe 0HH pacnpocTpaneHbl HOBCeMeCTHO.
Oco6eHHO MHOrO HX B 3eMJIe, 3arpfl3HeHHOn HaJIOM HillBOTHbIX H
tICJIOBCHa, B HO'IBO, 6oraTOI3 opraHHtieCHHMH yAO6peHH5IMn, B HOMe-
IIjOHi]HX AJIH 1RHBOTHbIX, Ha JORPOBaX TeJIa. BbicorfaFi yCTOntIHBOCTb
allaapo60B R TeMIIepaTypHnIM ISOJIe6aHHHM B03Ayxa, rnrciiXaHHIO,
JCHCTBHI0 COJIHCLIHbIX Jlytlen o6yCJIOBJIeHa HX cnopoo6pa3oBanneM.
YcJIOBHH, CHOCO6CTBylolljHe paaBUTnlo anaapo6oB B Txaxax
IIpit cJIytialiHbix paHeHHHX IIotITH HeH36eHino nonaAaHHe Ha no-
BOpXIIOCTb TpaBMHpOBaHHUIX THaHeL aHa3po6HiiX MHHpo6OB, B TOM
tJHCJIe II BbICOROBHpyJIOHTHbIX. B CBH311 C 3THM 3acHIyHifBaeT B]rHMaHHH
TOT (f aHT, MITO pa3BnTne aHa3pO6HOH lIH(eHunn no CpaBHeHnIO C FHOI3-
]IOn Ha6JIIOAaeTCfl OTHOCnTeJIbHO peAHO. AJIH ee BO3HHHHOBCHIIR
Tpe6yIOTCH HeCHOJIbRO oco6ble yCJIOBTII, B nePBylo otiepeAb HaJIH'IHe
TnaireBOi1 CpOAbi, JIHIIIeliHOII AOCTyHa HHCJIOpoAa.
B 3TOM OTHOIIIOIIHH nepBoCTerleH]loe 3Ha4eHHe 1MOOT TpaBMHpOBa-
Bile THa1Ie1I. B ytraCTnax pa3MHO?HelIHH, npoCTHpaionuixcf] AarIeio
OT paneBOro Hpafl, rJe THaHH npO;XCTaBJlenLI Heilhi3riecnoco6HOI3
Maccoi3, MnHpo6bl, B TOM tIHCJIe H aHa3po6hI, pa3MHO)HalOTC}I 6eC-
npeIIHTCTBeHHO. 3ACCb HCHJIIO'ICHbi MO6HJIH3aI[nfI 3an[HTHLIX CHJI
opraHH3Ma H npOTHBOAeHCTBne HX HH(eHTy HOHOCpeJCTBeHHO B MOCTO
CPO HHOKyJIRI[HH. BMeCTe C TCM HMeHHO B ytraCTHax OMCPTBOHHfI THa-
hIOH CyMeCTByIOT BCC yCJIOBHH JJIfI yencumOPO pa3MHOlHeHHfl MIIHpO-
6013, Hapaul1BaHHJI HX BHpyJIeHTHOCTH H IIaHOIIJICHIIfI TORCHHOB.
Oco6yio yrpo3y Ta5IT B ce6e paneini 1, conpoBoI1 alomileen pa3Jpo6-
JIeHHeM HOCTCI3. 06JIOMHIi nocJIeAHHx, norpymaicb BrJiy6b HOJ B03-
AeHCTBneM OPyJHH TpaBMLI, a B nOCJIeAyIOHjeM - IOAB14MHOCTH IT
CMemOHHfr, pa3pylnaiOT TKall H ycyry6JIHIOT TpaBMnpOBaHHe HX.
Bo36yuHTe7In aHa3po6HOn 14H(OHI1HH HaXOJHT Taume 6JlarOHpH1IT-
Hble AJIH ce6a yCJIOBHJI B CryCTlfax HPOBH, CHOnJIfnoii i xcci B pareBOM
Hallam II B Me1RTHaHeBLIx II;eJIHX.
BaMHbIM ( aHTOpOM, o6Jlergalon(HM pa3BHTHe H paCIIpOCTpaHeHHe
aHa3po6HOn 1111(f)eHIJI1H, HBJIHCTCfl IIOBpelRJeHHe HpyIIHbIX COCYAHCThIX
CTBOJIOB B o6JIaCTR parIemla. B 3TOM CJiytlae Ha IIo'IBC HeAOCTaTOgHoro
HpOBOcna6lTeHHH HJIH 3aTpyAHeHHOro OTTORa UPOBH H JIHM(I)bI H;H3HO-
CII0006HOCTb TnaHeH OAHOBPCMCHHO iio aBJIHOTCH Ha 60JIbIIIOM IIPO-
T1IHCHIIH.
YCJIOBHII allaapo61to3a HCH36e?HHO B03Hi4Ha1OT IIPH paHOHHax,
COnpoBOHHjaronjIIxcn o6pa3oBaHHeM y3HHX RaHaJIOB, IIpOHHHaIOU l1X
Ha 600ILIIIyI0 rJIy61,THy B M51FHHO THaHH. TaRHe Rana]mI, Half HpaBHJio,
BO MHOrnx McCTax IIepORpLITLI o6JIOMHaMH TI{aneli, ()acgHHMH, cMe-
igaiOIAHMHen IIOCJIC paneHHH, aHOHCBpo3aMH H MblmIIetlnb]MH nJIaCTaMH.
3TRM nCRJnOtiaeTCFI AOCTyII Bo3Jyxa B rJiy6olfne OTACJrhI panbI, rJe
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
06wmo CHOIIJIHIOTCH CryCTHH HpOHH, CJIy?KankHe HPH TaKnx O6CTOH-
TeJIbCTBaX 6ecKHCJIOpoAHOH IIHTBTeJII HOH CpeAol AJIH MHKpo60B.
K HaTeropl3H HOBpemAeHHU, HepeAKO oCJIO?KHHIOMHXCH axaapo6HOH
nH( emmeH, OTHOCRTCH HOJIOTI.IO paHbi, HaHeCeHHtIe BHJIaMH, yno-
Tpe6JIHeMbIMH gim y6opHH HaBO3a, 3arpn3HeHHSIMI3 rB03AHMH H Apy-
rHMH HpeAMeTaMH. CJIyiIaH aHaapo6HOii HH(eHI;HH HOAKO?KHOI3 KJIeT-
xiaTHH meH H noArpyAKa Ha6rno aI0TCH B MCCTe yxwia HrJioi , IIpH
norpemIIHOCTHX BBeAeHHH (no m30BaHHe 3arpa3HeHH16IMH nrrIaMH H
mHpHraMH) BaKI{HH H Jie*Ie6Hbix npenapaTOB.
B milpoxo aHHIOIIUHX paxax yC lIOBHH, HcHm0*iaioigHe cBo6owHbIK
AOCTyU BOa)yxa B rIIy6oHHe y-iacTKH IIOJIOCTH, co3AaIOTCH IIpH rpy6oM
TaMIIOHHponaHHH, HorAa c CHJIOi IIpoABHraIOTCH H Tyro cnpecconbl-
BaIOTCH HOMHH BETH HJIH MapJIH. IIpH 8TOM aHaap06Ko3 B TKaHHX
ycyry6JISIeTCH BCJIeACTBHe cAaBJIHBaHHH COCyAOB B o6JIaCTH paneHHH
H B CMO?KHNIX y'IaCTKaX.
0co6eHHo 6JIaronpHHTHa Aim anaapo6oB cpeAa B pa3MoaH eH-
HbiX paxax, npOHHKaIOIIxHX B TOJIHJy pMIXJlbix MbIIIIegimxx IIJIaCTOB.
3Aecb, HaK TO OTMemI0T MHorHe aBTOpbi, rJIHKOreH MNIHIA CJIyHKHT
AJIH anaapo6oB CnerwH(HLIecHHM a3IOMOHTOM nHTaHnl. I'IMeHHO MM-
menlHaR TKaHb IIOA B03AelCTBHeM rpy6oro TpaBMHpOBaHHH 6omlbme
BCero pa3pymaeTCH, IIpeBpan;aHOb B Hamm y, CMemaHHyIO C HpoBbIO.
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?IfeHO C HapymeHHeM KpOBO- H JIHM(006pau eHHH H HaHOnJIeHHeM
UPOAyKTOB 06MeHa B TKaHHX, HenocpeACTBeHHO npHJIeraiomHx H o iary
TpaBMM H yAaJIeHHbIX OT Hero.
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a IIpH HHHaIICyJIHpOBaHHH ero 'IaCTO OCTaeTCH B ApemmomeM 000TOH-
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H B HX OKpy?KHOCTH, OHH nor IomaIOT HHCJIOPOA H TeM caMbiM ycyry6-
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OTHOCHTeJIbHO iIaCTO IIOpaH{aIOTCH anaapo6xoYI HH(eKIIHe1 TIHmb
B TOM OJiylIae, HorAa paxeHHe CBH3aHo C MHOrOOCKOJIb'IaTbIMH nepe-
JIOMaMH KOCTeU. B o611aCTH 6piomnoH CTeHHH H B 6pIOmHOH IIOJIOCTH
aHaap06Haa HH(exAHH - peAKoe oCJIO?KHeHHe. 06,bLOHHeTCH 9T0
TOM, 'ITO 3Aecb oco6yio pOJIb HrpaeT KHme'IHan nanIOqKa: OHa HBJIHeTCH
aHTarOHHCTOM IIO OTHOIIIOHHIO H Clostrid. perfringens, Ha} K OcHoB-
HOMy IIpeACTaBHTerIIO rpynn IIaToreHHbix anaapo6oB.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Kaacdn4n1Kagna
HpogeccaM, OTHOCAII HMCA x aHaapo6HOH Hli4eHIHH, B AoaHTn-
ceIITHgeCxIIli nepnoJ( IIpHCBaHBanH HailMeHOBaima: rodnlTaaI HaB
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OTAeJIbHbIX CHMIITOMOB B npaKTHxe BbiAeJIAIOT TPII OCHOBHbie f )opMbI
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BHTeJIAMII rxoepoAHblx MHxpo6oB npugaeT 3a6oJIeBaHHlo oco6eHHO
TAxHeJImIH xapaxTep.
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KOTOPLIO B AaJIbHeumeM yMeHbnlaiOTCA. HHorAa n ollare nopalKerHA,
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OH 6UICTPO paCIIpoCTpaHAeTCH, 3axBaTbmBaa Ha AaJlexoM pacCTOAHHH
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OT paHbi nOARO}KHyIO, McH{MUmeVHytO, nepwBacxyJIHpllyIO, HepH-
HenpanbHyio KneTHaTHxy, MMmijw H pyre MHriHe TKaHH.
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JIHBaIOTCH ra3M. Haeaio raaoo6pa30BaHHSi HepeARO OTMe'laeTCH y3Ke
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peHTreHOJIOrH,qecKHe AaHHMe. 06MgHMM KJIHHHAeCHHM HCCaeAOBa-
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}I HBaIOTCH KpeIIHTaijHH, THMnaHH'qeCKHH 3By1 IIpH IIepKyceHH H
c6pHBaHHH BOJIOC (KCHMHTOM 6pHTB161N).
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B Ha*IanbHOH CTa)xHH aHaapo6Horo IIpoijecca. B AarbHeHmeM IIOKpOBbi
Terra B OKpyH{HOCTH paHM H Ha 3HaeIJTenbHOM OTAaneHHH OT Bee
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HeIIpHHTHMH 3anax. 3.TH CBOIICTBa paHeBoro oTAenneMoro Mario H3-
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4IeKIjHH, Ha6mojaeTCH IIOBMmeHHe TeMIIepaTypM Terra, yeaHjeHHe
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y'ian(eHHe H OCna6neHHe IIynbCa AaiOT Bee OCHOBaHHH Hpe9DHAeTb
HeHa6excayio rH6erb.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
06Ii Ho CMepTb HacTyuaeT HpH HBJIeHHHX TOHCIIYeCHOrO muxa.
Hepe,T;Ho HBOTHLIe ru611yT HO 90pore B JIetle6HHIIy, Tall Han rpo-
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HPH ABHHfeHHH HOCTynaIOT B IcpOBeHOCHOe pyCJIO H BLI3LIBaIOT yrlie-
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co6oii OCTpbI1i OTeR ee H CMepTb 1I{HBOTH0rO BCJIeACTBI1e ac()nxcIIH.
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eCJIH OHH HO 6bIJIII TpaBMHpOBalmI HpH paHeHIIH.
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C II3MeneHHHMII ee XIIMII3Ma TOJIbHO CH0006CTByeT TpOM6HpoBaluIo.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TaRHM o6pa30M, COCTORHHO RpOBH, CTeneH6 ee CBBpThIBaeMOCTH He
RBJIReTCR nePBHtiHbiM 4 aRTOpOM o6pa30BaHHR TpOM6OB H pacIIpOCTpa-
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OCTaIOTCR nPOXO;XHMMIMH. PeARO Ha6JIIo aIOTCH TaR}Re nopa neHHR
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)KeHHH HfHBOTHorO TRaHH CMenga1OTCR B IHHPOHHX rpaHHiRax (pHC. 78).
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Hbix: rH6eJIb co6aR H RomeR yj[aeTCR npeAOTBpaTHTb, Rorj[a aMHyTa-
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XO3RHCTBOHHbIX H{HBOTHbIX 6ypnoe TeueHHe 3a60JIeBaHHR B o6JIaCTRX
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pOBJIeHHfl B nepHoj[ JietieHHR CJIy>HHT yMeHbIneHne oTexa THanei
C OjjHOBpeMeHHMM 1ORBJIBHHeM 6onee ryCTOPO axccyj[aTa H n3MeHe-
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CTByeT 06 yracaHnn aHa3po6HOH HH()eRT fH H 0 ;XOCTaTOtIHOH M06HJIH-
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
paccegeHIIe nepeMldueH, yCTpaHeHlIe HapManoB, ygaJIeHHe crycTxoB
HpOBH AOJI}HHbI 6LIT16 OCyH(eCTBJIeHbI C AOJIMHOII noca mBaTeJIbHOCTbIo
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3aTpyAHeHHI3 yAaJIHTb He}Hn3Hecnoco6Hble THaHH II HHOPOAHble TeJIa,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cnygaax HeT HaAo6HOCTH npHMeHfTb rny60HHH Hapnoa, Tax Kan
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
3HagHTe7IbHOe ROJIHLIOCTBO RypHonaxHylux, Ran ceponoRopo), Me-
THJI-MapllanTaH, HHROJI, aMMHai H Rp.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
U McCTax 3wrepogeHTe3a TOHI{HM TpoaHapoM. IlpHMepOM aHAoreHHOH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
1'HHJIUCTHaH HH(keKuHH B Taxog paHe BfAiMBaeT paClInA rpaHyJIH11fl1,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Oar HH(eII;HH BCKPbIBaIOT IIIHpOKHM paapeaoM. OMepTBeBMHe
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CIIEI(HtHVECHHE HH*PEJ L(IIH
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Y xpynxoro poraToro CHOTa *IacTO nopaH{aeTC 11 3 M H, B HepBylo
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HHTHaMH H uoJlocxaMH. OTJSeJIbHMe y3ennx a6clteAHpyloT ii IronocTH
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ha J;pyrnx opraHOB y KpynHoro poraToro CHOTa B OTJ[eJILHbIX CJIy-
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B ytiacTHax TeJIa, J(OCTyIIHI1X HCCJIeJ[oBaHHIO OCMOTpOM II HaJIb-
nal;neil, xapaHTepxble IIpH3HaHH 3a60JICBaHHH oIIpeJ[eJiaioTCH 6e3
3aTpy))HeHHLI H gHarHO3 yCTalaBJIIiBaeTCH JIerHO. Me exnOe yBeJIH-
i1eHHe o6leMa HpHIIyXJIOCTH, OTCyTCTBHe IIp143Ha1OB 9HCCyJ[aTIIBIIOII
peaHI;HH, 0T'IeTJIHBar rpaHHIra rpaHyJleMbl B OnpeJ];eJIeHHOIi o611aCTH
Teiia Him opraxa, 3Ha'IHTeJIbxoe YIIJTOTHOHHe THaxeHI 6e3 3aMeTHOro
IIOBMIIIIeHlg HX LIyBCTBHTeJIbHOCTII, 60a mxopaJjo'IHOe TeL1eIIHe 3a6oJie-
BaHIIH, orpaHntieHHoe rHOeOTgeJIeHHe IIpn iipopbIBe otiaroB THaHOBOrO
pacnaJta H B J(aJIbHeIIIIIHH IIep1OJL Cy1I1e0TBOBaHIIH CBIIIILOH J[aIOT
J[oCTaTOLIHble 0CHOBaHIIH HpegnoilaraTb HaJTntJHe aRT1HOMn10MbI.
Iipn IIOpaHfeHIIH HO HH o6pawaeT in ce6H BHHMaH1e yMOHbIIIeHHO
ee HOJLBH}HHOCTH B yTIaCTHe pa3pacTailHH y3JIOB, a B 60Jiee IIO3J[I1He
cpoiH - nolBJIeHHe MOAJICHHO 3a7HIIBaI0IIwnx CBHMeH H HOBLIX 143B11-
TbIX HaHaJIOB (IIpopiABbl rHOH), IIOCTeneHHoe pa3paCTaiI Te rpalyJieMbl
B CTOPOHLI H BrJIy6b, B0BJIetIeHHO B IIpOIL000 COCCJ[HIIX THaHeH, B TOM
t1IICJIe H HOCTeiI.
Ilopameane H3hIHa, HOMIIMO OTMC'IeHBLix anaTOMHTIeCHIIX II3MeHe-
BIIIl, 13b13LIBaeT 3aTpyJ[Hexne aHTa wesaHIIH, 0614JIbIlOe OTJ[eJ1eHBe
CJIIOHbl, CBIICaioMel3 TmIIaMi3 113 POTOBOII IIjeJIn. Rorga H3b1H 3HaLIB-
TeJIbHO yTOJIWeH, OH BbICTyIIaeT H3 POTOBOiI IIOJIOCTH, IIO LOJIry OCTaio-
II[eHCa 0THpbITOII. IIpu 06niHpHhIX LI3MeHeHBHX H3bIHa H OAHOBpeMeIl-
1 M nepexo a rpaHyJleMaTO3HOro npoi ecca Ha IIOgLIemlloCTHble, 3arJIo-
TOLIIIbIC H BOpXHeIIIenHMe JIIIM(JaTIFIeCHHO y3JIbI pa3BIIBa0TCH OTCH
B ytiaCTHe nepeJSHero OT LCJIa BOHTpaJibHOI3 Iio?HHOi CHJIaJ[HH IIIen,
06y~CTJ10BJIeHHLIn 3aTpy LHeHHeM OTTOHa JIIIM(Jbl.
eY 1HIIBOTHbIX C JLn(JJ )y3HLIM aHTHHOMHH03OM H3bIHa, AeCeH, meBa-
TeJIbHbIX MYCHYJIOB, a TaHme c pa3paCTaHIIHMH alTHHOMHHOM B CTeHHaX
rJIOTIIH H 3arJI0TOtIHbIX JIIIM(aTntieCHIIX y3Jiax paHbme HJIH nOame
HaCTynaIOT rJIy6oHHe pacCTpOIICTBa aHTa IIpneMa HopMa; OH13 6LICTp0
xyueloT.
CO 3Ha'qnTeJlbIILIMI3 3aTpyAHeHnnMn B JjHarHOCTIIHO CTaJIHBBaIOTCH
IIpn JI0HaJIn3aILnli aRTIIHOMIIHOM B JIOPHIIX 11 B OpraHax 6pI0TIIHOu
IIOJIOCTH. B paHiteii CTagIIH 3a60JieBali4n B 3THX cJlytiaHx IIMeIOTCH
OCHOBaHHH HOA03peBaTb eymeCTBOBaHHe XpOHliti0CH0r0 npogccca
HOOIIpeJ[eJleIIHOii npnpOAbI. B IIO391JHe CTaI JLuIarHOCTHHa He-
CHOJIbRO 06J1ertIaeTCH B CB13II C pacnpoCTpaneHueM ffi14)IIJIbTpaTa
Ha Jxpyrne, cMeHtHbie Opr8HM H Ha CTOHHH r1oJIOCTeu.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
,oCTOBeprnrn gHarHo3 aHTHIIOMHKO3a BO Bee IIepHOAM ero Tene-
HHfi ycTaHaBJIHBaeTcf MHHpoe1ouleH ai eeyjjaTa H rHCToJlorHgecxgM
HccJIe)joBaHHeM HyCO1HOB HCCOHOHHhIX THaHei3. IIp06b1 aHeeyAaTa
MOT 6LITb B3HThI HaR HeIIo-
CpeACTBeHHO H3 CBHH[el, Tau
Pnc. 83. Apyaa Streptothria
actinomyces.
HphITNX rJIy6oHIIx oiiaron.
CTpyHTypa HaxOAHIIjHXCf1 B
HHX 3epiiblmeH, pa3AaBJIeHHmIx
MemAy IIpeAMOTHbIMH CTeHJIa-
MH, CTaHOBIITCH 60JIee 3aMeT-
HOH nOCJie npeABapHTeJm ouu
o6pa60TEH MaTepnaiia 10%
paCTBOPOM CAROM immn
(pHe. 83).
Hporaoa
B IIpoIHJIOM, AO BBeAeHHA
B npaHTIIHy JIegelInn npH aH-
T14HOMHH03e npenapaTOB HoAa
(1885), 3T0 3a6oJlesaHDe CTIH-
TaJIH 'lpe3BLImaffiIO THHfeJmIM,
yrpo}IfaIOHjlM )HH3HH BO BCex cJIyLIaHX, rAe HeocyII[eCTBHMO onepa-
THBHO0 yAaJleHHe rpaxyJIeMII. ilpHMeneHne HoAa AaJio B03MOHf-
HOCTb 3HanHTeJIbHO yJIyqIIHTb TepanuIo. B COBpeMOHH1IX yCJIOBHfix,
IIpH HCIIOJIb3OBaHHH HeHOTOpbNX alITn6HOTHHOB, Aaxce TfiHSeJIble CJIy-
YaH aHTHHOMHHO3HbIX nopa]HeHuH MHPHHX THaHeI MO}HHO OTHeCTH
H HHCJiy ycuemHO Hypa6HJIbIIbIX. IIpn 3anynjeHllbix npor eccaX c JIB-
JleHHflMH oCTeoMH3JIHTa, pacnaAa amlbBeoJIOB, IIOpameHHfi Mo3ra,
a TaR)Ife opranoB rpyAIIOn H 6piomIIOIi IIOJIOCTei3, nporno3 AoilmeII
6LITb OCTOpOHfHMM HJIH COMHHTemHbIM.
OrpaHHqeHHbie aICTHHOMHHOMbI, AOCTyHHble yLaJIeHHIo oHepaTliB-
HMIM HyTeM, Beero pau[HOnaJibHee HCCeHaTb B npeAe5iax 3AOpOBbIX
THaHeII. IIpH CyWCCTBOBaHHH 3a1pLITbix rJIy6oHHX HH4)HJIbTpaTOB
H rpanyJleMaT0311bix pa3pacTanl1, HorAa B ToJITI e Hx HeT 60JIbIIIHX
riIoiiHbIX IIOJIOCTeH, HCIIOJIb3yeTCH HOHCepBaTHBHLIH McTOA JIe'IeHHfl
npenapaTaMH HOAa, IIOHHAHJIJIHHOM HJIH CTpe1TOMHA14HOM. TpaHy-
JIeMbI, BCxpbIBHileCH HapyHSy c o6pa30BaHHeM CBiIlI(eui, ijeJieeoo6-
pa3HO IIOABepraTb XHpyprHLIeCHoA o6pa60THe: paemmupHTb HaHaJIbI
npOpbIBa pa3pe3oM; TII 3TOJIbno CHapi(lnljHpOBaTb H : CTeHHH OCTpOI3
JIOMiOI3 HJIH KiopeTHOYI; TaMHOnnpOBaTb HJIH Ape1HpOBaTIb MapJIeM,
IIpOiFTaHHOH HaCTOHHOA HOAa, HMHperIIHpOBaHHOH HOAO(OpMOM.
B noe ieonepagHOH biII HepHOA HOCJIeAOBaTeJIbHO IIpHMenfIOTCH HOAO-?
Tepania, IIeHHI(HJIJIHH HJIH CTpenTOMHBHH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Id. o A 0 T e p a n H H. 143 gHCJia npenapaTOB HoAa Hal6oJlee
IIlnpoHO HCHOJIb3yeTCfl HOAHCTbI1 HaJIHI3. Ere, Ha3HaTfaI0T BHyTpb
B Awe 6,0 (AJIH HpyIIHOr0 poraToro ClfoTa CpeAHero Beca), pacTBO-
peHHhIM B 1 JI BOAbI, B Te`IeHge 10-14 AHeg. H 3TOMy BpeMeHH rpa-
HyJIeMuI 06bILIHO 3aMeTHO pa3MHrnaI0TCH. B AaHIbHeHIIIeM Ha npOTfi-
HCOHHH TflHOr0 we cpoHa AaIOT IIOJIOBHHHVIO A03y. Ecim H HOHijy
BTOpOII HeAeJIH 60JIbIIIHC 903bM HOAHCToro HarIHa He OHa3bIBaIOT BbI-
pa)ICennoro JIege6Horo ACHCTBHH, BO H36omaHIIe HOAH3Ma AejIaIOT
nepepbIB Ha 7-10 AiieI H 3aTeM IIOBTOp$IIOT HypC. B(j4eHTIIBHbI
TaH?Ime moroJIeBCHHu paCTBOp (BHyTpHBeIIHO B 903e 20 MJI IIJIH B TOJIIIjy
axTHH01%IHHOMbI), HOAHCTbII3 HaTpHH (BHyTpHBeHHO B 9030 10,0 Ha
150 MJI BOAbI) H pyre npenapaTbi (Jatren, Cejodil) AJIJI BHyTpIIBeH-
Here II BHyTpHTHaHHOro y11oTpe6JIeHnfa.
HeHHB;B:JIJIHHOTep anHn IIpH aICTHHOMnH03e 3acJly-
MHBaeT oco6oro BHHMaHH}I B Tex cJlyqas1x, HOrAa Te'IeHHe IIpoijecca
OCJIOH{IIeHO Heduer rn IITIeeHOH rHOlhIOH HH()eHAHeH. I4CnOJIb3yeTCA
o61geIIpIIIIHTa5McTOAHHa IIOBTOpHLIX HH'beRIU IlpenapaTa B Ao3e
200-300 TmIC. CA. B Tetlenue 6-8 AIIeI. OTCYTCTBIIe IIOJIOH{HTCJIb-
HOPO 3(j)(J3eHTa H HOHljy IIepBOH HeAeJIH JIeLIeHHfI CBHACTOJIbCTByeT
o6 YLIaCTHH B IIpoIIOCCe IIOHIIIjTJITIIIIIOyCTOIIqIIBbIX CIIeIjH(JHiIOCHHX
B036yAHTeJIeI3 HJIH ruoepogHLix MHHp060B ceHylIAapHOH nH(j)eH-
IjHH.
C T p e II T 0 M H IX II H o T e p a II H fI OCYWOCTBJIHCTCH TOM }He
McTOAOM, iITO H ndHHJjHJIJIHHOTeparHa. AaHHble, nMeIOIInueCH B Ha-
CTOHIIjee BpeMH, CBHAeTeJIbCTByIOT 0 BbICOHOH AOHCTBeHH0CTH ee game
B HpaIIHe 3anyll1eHHblx CJIy'Ianx o6mnpHbix HopaHieHHII mblxa c Be-
BJIe,IeHneM B upoijeCC JInM(aTw1ecHHx y3JIOB, HorAa HfHBOTIIOC HCTO-
HjeHO B CBFI3H c HapyfellHfiMH ?HenaHHH II aHTa uporJIaThIBaHHJI HopMa
(JIHTIHbie Ha6JII0AeHIIfI).
BoTpHOMIiHO3 - CIWAH()WIecHOO HII(j)ORI[HOHHOe 3a6oJIeBaHIIe, B03-
6y,j14TeJIeM HoTOporo }IBJIgeTCH Micrococcus botriomyces equi,
s. Micrococ. ascoformans, a Ho AaHHLIM HeHOTOpblx aBTOpoB Staphy-
lococcus ascoformans. Ida6JIlogaeTCfl oHo cpaBHHTeJIbHO gaCTO y JIO-
maAeH; Apyrne BHAbI HCHBOTHLIX (KpyuubIH poraTbIH CHOT, CBIIBbII)
3a60JIeBaIOT HCHJIIOLIHTeJlbHO peAHo..
Hii(HI[HpoBaHHe HpH 6OTpHOMHH03e IIPOIICXOAHT rJIaBHbIM -o6pa-
30M BCJIeACTBHO TpaBMHpOBaHHH HO}HH (TpeHHe XOMyTOM HJIH mOp-
i{OH), a TaICHSe 3aHeCeIIHH Bo363AHTOJIeii B paHbi. B COOTBOTCTBHII
C TaHHM MexaHH3MOM 3ap I?HeHHJI otIarH CnerW wIeCHOro BOCnaJIeHHfI
06bl*IHO Ha6JII0AaIOTCJI B o6JIaCTH XOJIHH, B hpeAJIOIIaTOLIHOM OTAeJIe
IIIOH, B MomoHHe IIOCJie HaCTpaI[HH, B BbIMeHH. THaHH Apyrnx o611a-
CTeI3 nopamalOTCn B e)IIHH'IHLIX CJIygagx.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
RepBoHanaJIbHOe Bo3geI3CTBHe BO36y)I,HTe7Ix Ha opraHl3M COHpO-
Bom aeTcH 3ICCCyAaTHBHMM BocuaJleHHeM. B gaJibHeiimeM Ha HepBbII3
HJIaH BbICTynaOT npo iia epai un coeAiuIHTerIbHOYI TKaHH, I{au fiBJie-
PHe. 84. ,Apy3a Micrococcus
ascoformans.
HHe, xapaRTepHOe AJIH Xponn'ieCHOro
rpanyJleMaTO3noro Ilpouecca. B Te=Ie-
HHe AJIHTeJIbHOrO BpeMeHH 6yrpricTble
pa3pacTaHHx rIOCTerIeHHo yneJlntIH-
BaIOTCU. B HX TOJIWO Bo3HHi{aIOT ouarH
pacuaga HOBOO6pa3OBaHHOII THaHII B
(opMe He60JIbIHHx a6CueccoB, IOJIOCTH
HOTOpbIX 3anoJineHbI CJI143HCTbIM, opaH-
?xeBblM HJIH mac paHOBoro OTTeHxa
rHoeM. IIpu MHHpOCROHHpOBaHHH (CJIa-
60e yBeJInLIeHne) Mail{a ero BJt Hbi
6eJIOBaTble CJIH3HCTbIO 3epHMIIIHH, CO-
J[ep}KawHe I{OJIOHHH B036yJ;11TeJIfi 3a6o-
JIeBaHHfi (pHc. 84).
bone caMoupon3BOJibnoro Hpo-
pblBa, o6Mtixo of;HOBpeMeHHorO BO
MHOrHX yuacTn{ax rpaIIyJleMbI, a TaHH{e
B McCTax pa3pe30B OCTaIOTCfi CBHIITH c He3HagHTeJlbnLIM rHOeOTJ{eJIe-
HHeh. B Hpoucce 3anwBJIeIIHf Hapy?KHble OTBepCTHH ux HaHanIOB
BTHPHBaIOTCFI BrJIy6b, H py6AbI B nocneAyion eM OCTaIOTCR BOpOH-
xoo6pa3HO Horpyu{eHHbIMH.
B 3aBHCIIMOCTH OT rny6HIIbi pa3pacTaHHfi rpaxyJleM II3MOHCHHFI
TI{alien Maupocuorin ecin HeCHOJIbI{o pa3JIHLIIIbI. Hopaufenue H 0-
BepXHOCTHbIX cn0eB I{o?HH xapalTepu3yeTCfl pacuaJ[oM anH-
gepMHCa H HbiambIM rpaxyJIHpoBaxneM C o6pa3oBaHHeM BbInnLIeH-
HLIX y3JIOB.
B cniy=Iae JIoraJIH3ar(HH y3JIOB B T 0 JI III a I{ O ?I{ H, B HatIaJIbuOM
nepnOAe 3a6oJleIlanufl oTMetlaeTCFI 6yrpHCTOCTb ee, BNICTyIaIOluaa
HyroBiIaTMIMII Bo3BbImennflMH. B gaJlbHeAmeM, c pa3p0CTOM CoeJtHHH-
TOJIbROi3 'mall, y3JIhI yBOJTHilmBaJOTCII B o6TCMe H CTaHOBHTC$ 6OJIee
HJIOTHMMH, oco6elHO no Hepnf epnH. B IICHTpaJIbHLIX yLIaCTKax OHn
paCnaJ;alOTCH. 3AeCb o6pa3yIOTClI fI3BLI, HOI{pbIBaiommeJI pbIXJIHMH
rpanyJlfil;niMn. Ha MOCTaX 8aH{HBHInX n3B OCTalOTCII 3Be3gLIaTbie
Py6ubl.
B rJIy60ICHX CJIOHX TuaHOH 60TpHOMHHO3 3aXBaTbIBaOT B nOpByIO
oaepew m y c u y Jr Li, =laH[e BCero rJJIege-roJIOBHOiJ. rpaHyJleMbl B ero
ToJllue AOCTHraIOT oco6enno 60JIbfIBX pa3MepOB (pHC. 85).
Hjnr 6oTpnoMHK03e BbIMOHH 0TMetlaeTCH McCTaMH ero yIJIOTHOHHO
B (JIOpMe y3JIOB, 3HaiIHTeJlb1-1oe yI3eJIHVIeHHe, orpaHHneHHe HOJ(BHxc-
HOCTH B OTHOlUeHHH npHJieralOHAHx THarel3, a Tal?I{e cpacTaune Ha
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
coo6n aIOmMHCH B rJIy6HHe c OTIaraMH HarHOOHHH HyJIbTH ceMeH-
:HHHa HaHaTH11a.
011 IIepeCeLIeH B pa3JIHTIHTIX HaIIpaBJIOHIIax CBHH;eBLIMH ItaHaJIaMII,
po?H eIILI H IIpeACTaBJIAIOTCH B B o6JIaCT11 men H BJIe-IeBOro CyCTaBa.
MOMOHHH Ta11}HO CfH6p03II0 IIepe-
It 14XCH CBHIIle13. -
.HaTOJloroaxaTOMHTIeCKHe H3Mexe-
HHH xyJIbTH ceMeHHoro HaHa-
T H 11 a IIpH 60TPHOMHH030 BOCbMa Xa-
paHTepHbl. B pe3yJIbTaTe o6HJIbuoro
pa3pacTaHIIH CJH6p03HOH THaHH oHa
y}HC B TeTIeHHe IIepBOii HeAenI
cyu eCTBOBaHIIH IIpouecca HpeBpa-
H(aCTCl B MaccHBHoe 6yrpHCTOe
o6pa3oBaHHe, HJIOTHO CHaffHHoe c
BJIaraJIHHZHoI3 o6OJiot110I3. HocaeA-
FTfFg IT ATTA! TTIT.TTIxT1 TTTATITI PTPTITfTI
o611aCTII BMMOHII 6LIBaIOT oco6eHHo
Hp11o BbIpaiHeHw BopoHHoo6pa3HLIe
06MHpIiOM IIpoTHHSeHHH HOMII OT-
AOJIbHbIMH yTIaCTHaMH HJIH ~A~7HC Cy3H0
C TnaHbIo rpaHyJleMLI. I1MeHHO B
TeHeHHe H HpOPHO3
3a6oJIeBaHHe rlpoTeiaeT xpoH114 0CHH - MecHuaMH II HepeAHo roAa-
MiI. l,JIHTeJIbHOe BPOMH rpanIyJleMaTO3Hble pa3paCTaIIHH, JIOHaJIH3OBaII-
HIile B OIIpeAeJIeIIHOH o611aCTH Tenna, He BL13bIBaIOT cepbe3HLIX 143MeHenuH
B opraHH3Me; paCCTpO1 CTBa ABHHCeHHYI, o6yCJIOBJIeHHble IIepepO}HAe-
HHeM T11aHeu H orpaHIITIeHHeM HX B3aHMocMeIgaeMOCT11, MOryT AOCTHraTb
BbICOHOII CTeIIOHII. IZporHO3 B TaHIIX CJiyTianX BCe 1110 6JIarolpIIHTHbII1.
CyweCTBOBaHHe MHO}IICCTBa o'IaroB HarHoeHIIH HpH 06ID1PHOM
IIOpa}I1eIIHH H 3aTpyAIIeHHOM OTTOHO 311CCy)aTa IIPHBOAHT 11 JlHxopa-
AO HOMY TegeHHIO IIpor(ecca c McAJIeHHO IIporpeCCIIpyioweIi HaxeH-
CHeH; 1103TOMy HpOrHO3 B TaHHX CJIygaHX COMHIITOJIbILIH.
PaCIIpoCTpaHerlHe IIpor ecca B o611aCTH, MaJIO AOCTyIIHII0 onepa-
THBHOMy BMeIHaTeJIbCTBy (HanpiMep, B 6pIomHyIo IIOJIOCTb HpH IIepe-
xoAe ero C 11yJIbTH CeMeHIIoro HaHaTHHa), AIICCOMHHHPOBaHHe B 110}He
Ha 6oJIbmmle pacCTOHHHH OT IIOPBHTIHOPO oqara, IIOBTOpxbIC peAH-
AHBbI IIOCJie onepaTHBHbIx BMemmaTeJIbCTB, a TaH}ICe reHepaJIH3aqHH
C o6pa3oBaHIIeM BTOPIITIHbIX y3JIOB BbIHy}HAaIOT CAeJIaTb BMIBOA
O HeH36e}ICHOCTH r116eJIH }1114BOTIIoro HJIH o Bb16paHOBxe ero.
.JTeTIeHHe
PaAHHaJIbHMIM CIIOC060M TepaIIHH HBJIHeTCH 3HCTHpnaB;HH rpaHy-
JIeMbI. rIpl JIOHamIII3OBaHHbIX HOpa}Ifeunnx 11011111 MOrYT 6bITb c yCIIe-
XOM HCIIOJIb30BaHuI IIpH}HHraHHH. B HageCTBe AOIIOJIHHTeJIbnOrO
I I
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JiegeHHH, ycKOpH1OuJeru paccachiBaHHe H npeAOTBpaDAaroH(ero Boa-
HHKHOBenne peuHZ[HBa, I(eJiecoo6pa3xo xa3Hatlenne HOAHCTOrO KaJinH,
peHTreHOTepanHII, a Tai?Ke TKaneuo1d TepanHH, nepeJIHBaHnH KPOBII
aJin ayToreMOTepannn.
CTPEHTOTPHX03 (HCEBROAIfTHHOMII{03)
BO36yAnTeJib CTpeITOTPHXO3a - rpn6 Streptothrix actinomy-
ces canis (Cladothrix canis) - o61,I'nlo npOJ nxaeT B TKalin npH pa-
HeHnHX, 3agacTylO npn BecbMa orpann ierHbix, HOBepxHOCTHLIx Ho-
epeH{Z[eHHfix KOHCi.
3a6oJienaHne oTHocnTeJlbno gacTO BCTpeiaeTCH y co6aR n peAKO
y JiomaAeii. HagarIo ero xapaKTepH3yeTCa HOHBJIeHHOM B 1OZ(KOHfHOI3
KJIOTgaTH0 H KOH{e OAHOPO 1JIH HCCKOJIbKIX orpaHHgeHHbix ogaroB
AOBOJIbHO 1JIOTHOro HH(JIHJIbTpaTa. TaKHe ogarn gacTO o6Hapy1KH-
BaIOTC1 B rJIy6HHe, B cJIOHX MeH MIIInegnoyl KJieTgaTl{H. 'Iepe3 He-
CKOJibKO AHOH OHH pa3MHrgaIOTCfI H npopIIBaIOTCH; npH TOM o6pa-
3yIOTCH o61nnpHbie HeEPO3bI KOHfH H (1CTyJIe3Hbie KaHaJIbI, BMCTJIaH-
Hble pMXJibIM rpaHYJIfii[HOHHLIM loKpOBOM. U anaribl CBiimeH HHorAa
UMeIOT 3HagHTeJIbHyIO AJIHHy.
PernoHantbnMe JIfM())aTngecK ae y3JIbI IIpHnyXaIOT H BO MHOPHX
CJiygaix a6cIieAnpyIOT. PacnaA HX IIpOHCXOAHT B TOM cnyllae, Korua
ogarn Ilopa?KOHHH lPOCTHpaIOTCH B Me?EMbIInegHbie HPOM0?R TKH H
o6pa3yIOT MHOH(OCTBO KapMaHOB.
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pMIBOM 9nccyAaTa OHa yracaeT H B AanbHeiimeM cTaHOnnTCfl CJIa6eil.
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JieHfaT IIOgTH B TaHOM me MnrHOM JIO?Ke TKaneii, KaH H B nepBbie AHH
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gncne pa3BHBaIOTCH B o6JIaCTH inert, TyJIOB1I[;a H K011e1H.OCTeH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
'HaH6OJiee zlacTbiM oCIIO?i{HOHHeM IIpH CTpeuTOTpHxo3e HBJIHeTCJI
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B OTCyTCTBHe CHMIITOMOB THH{eJibiX HapymeHHli.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ROB, HX IIpHJ[aTROB H ceMeHHbix ny3bipbxoB y 6MROB H XpHROB. TaRHe
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H CTOHOR CJIH3HCTbIX CyMOR, LITO LIaCTO Ha6JnoJjaeTCH B o6JIaCTH XOJIRII
y JIomajjell, HBJIHOTCH (JaRTOpOM, CII0006CTByIOIIUHM pa3BHTHIO cIIe-
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THBHOrO nocnauIeHHg B CJIH3HCThIX II CHHOBHauubHMIx IIOJIOCTHX,
a Tax}RO B ceMeHHHRax, IIx IIpnJ[aTxax H ceMeHHbIx IIyaMpbHax y H{H-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BOTHMX, 6onbHMx 6pygenne3oM. HMeHHO B TaKHX cJlytiagx AJIH O6'bHC-
HeHHH MexaHHaMa HH4)HIUHposaHHH BMABHraeTCH rnuOTe3a o ?Hexo-
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xseHHH uojo6Horo poAa Ma1IO y6eAHTen6Hrj.
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LIHBOM opraHHaMe yenemno 4laroItHTHpyIOTCH B TKaHHX H opraaax
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6naronpHHTHbi, KorAa MHKpo6M cocpeAOTOtiHBaIOTCH B coAep)KKMOM
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IIOCTOHHHbIM coAepxcHMMM, no Mepe paaMHOxceHHH 6pyijenn H Ha-
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CTByIOIIWX opraHOB B IIepHOA HH41HIuHposaHHH K B TetleHHe Bcero
noc IeAyIOIIjerO Haxonc eHHH HHl eKIjHoBHoro areHTa B opraRHaMe.
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IIanbljeBOe H TapaaJIbHOe CyXO)KHnbHMO BnararmIIja).
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IIOAOCTpMX HJIH xpOHHtleCKHX 6ypdHTOB, TeHAoBarHHHTOB, axccyAa-
8. 243
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
THBHbIX apTpHTOB (npHnyxaHHe, (JIIOHTyagHH, cTpeMJleHHe )HHBOT-
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HbIX rpynH xHpyprHLIeCHIIx 60JIbHbIX.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
1'JIABA %
OMEPTBEHHE (NECROSIS)
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pOHbI, pacmHpIIIOTCH CyuJecTByI0MHe allaCTOM031a, c Apyron - HOBbIO
COCY bI IIpOHHHaIOT B ygaCTOH uopa?HeHHH H3 oxpyH{aI0IIkHx THaHeH.
Pa3BHTHIO HeHpo3a C0J(elCTBy10T H yCyry6nsloT ero TegeHHe
MHorHe IIaTonorHgeCHHe COCTOHIHHH: yIIaAOH cep)je1iHO-COCyJWCTOH
J;egTenbHOCTH, HCTou eHHe H(HBOTHoro, oxnam eHHe, aHeMHji. HpH
TaHHx o6CT0HTen16CTBax, eCTeCTBeHHO, 3aTPYJZHeHO TaH?He HOnna-
TepanbHoe HpoBoo6pal1jeHHe. Oco6eHHO 6ypHO IIpoTeRaeT HeHpo3
THaHeH, HorJ[a H COCYAHCTbIM paCCTpOHCTBaM IIpHCOeAHHsIeTCH aHa-
apo6Hal HH(eHZrnl.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HaaccHlnIIKaI;IIH
rH6eJIb KJIeTOK H THaHel HeH360}KHa npH paHeHnfiX H 3aHphITblx
TpaBMaTHLIOCHHX IIOBpe?E eHHFIX, IIPII HH(eHI;HOHH1Ix II MHOrHX
jjpynix 3a6OJIenaHHFIx. B 3TIIX CJIy'IaFix MHOrle gpyriie 11p13HaRH
npouecca 3aTylneBbIBaIOT co6oiI HBJICHHH, 06yCJIOBJIeHHMIe IIenoCpeJj-
CTBeHHO HeRpoTnilecHHMH 113MexeHHfIMII. 0 H e x p o 3 e roBOpRT,
Hor a Heo6paTHMble AeCTpyRTIIBHLIe II3MeneHHFI TKaHeH H opranon
MHBoro opraHII3Ma FICHO BbIpameHbI H HpeACTaBJIFIIOTCH OCHOBHBIMH
B KOMIIJIe1Ce naTOJIOrWLIecHHx }IBJIeHHH.
AHHaMHHa IIpoijecca BapbnpyeT B 3aBIICHMOCTII OT IIpHLIIIHbI,
BhI3BaBineH OMepTBeHHe, 11 yCJIOBHII, B HOTOpIIX 0110 HpOTeHa?T. Ha
3THX OCHOBaHHHX pa3JIHLIaIOT: H o a r y JI H Ij II 0 H H bI II (C y-
X O iI) H e K p o 3, icorJja npoijecc CBFI3aH C yIIJIOTHeHIIOM TKaHeH
B pe3yJlbTaTe CBePTbIBaHH$T HJIeTOLIHOH IIpOTOHJIa3MbI, II H e H p o 3
KOJIJIIIHB aIIHoHHbIH (BJIa}HHbIA), Kor a oMepTBeBalo-
MHe THaHH pa3MHPiialOTCH IIOJj BJIHIIHHeM I epMeHTOB, Ha6yXaIOT H
B nOCJIegyIOIIjeM IIpeBpaiijaIOTCH B HOJIy}HHgKyIO Maccy.
Oco60H 40pMOH OMepTBeHIIH THaHOII HBJIHeTCH r a H r p e H a.
3TO HaHMeHOBaHHe II HCBaHBaIOT *iaCTHbIM cay1asiM iiexpo3a c go-
HOJIHHTeJIbHbIMII H3MeHOHIIRMII IIorI61IIHX THaHel n0jj B03)jeICTBIH0M
( aHTOpOB BHemHeiI cpe)jbl. B IHcae IIX oco6oe 3HageHHO HMOIOT BbICbI-
xaHHe B pe3yJl16TaTO IICIIapeHIIH BJIarH H pacnag 6eJIKOB IIOlj BJIHHHHOM
]KH3He;kegTeJIbHOCTII MHKp060B. B IIepBOM cJlyqae pa3BIIBaeTCH C y-
x aH raiirpeH a (gangraena sicca), no BTOpOM - BaaxcH a ti
(gangraena humida).
YLIHTbIBaH 3THOJIOPHIO H naToreHe3 IIp0I[eCCa, BMJj0JIHIOT OMOpTBO-
HHH, o6ycJIoBJIeHHmc: 1) McXaHHLIecHHMii II0Bpe9lcg eHii FIMH
(paneHHH, ymii6bi, cJjaBJIeHIIe TKaHeH), 2) H a p y III e H H e m II p O-
XOJjHMOCTII COCy) OB (IIpH 3M6omIIIH, TpoM6o3e), 3) TOpM11,1e-
CHIIMH II XIIMHMeCKHMH BO3j[eiCTBHFlMII, 4) TOKCII*Ie-
CKIIMH H IIHC OKIjIIOHHbIMII 3a6OJIeBaHHSMII, 5) TpO-
4IOHepBOTHLIecHHMH paCCTpOIICTBaMH.
Hexpo3, B03HnHmHii B onpejjeJiennoM yLiacTKe TejIa, IIpH OTFIrO-
n aiou iix o6cTOFITeJIbcTBax (ynajjoH cepgeiIHOii geaTeJImHOCTH, Hapyme-
HHFI O6MeHa BeII;eCTB, HH(leHLj4FI) BO MHOrHx CJIy1Ia}X nporpecclipyeT;
HocneJjoBaTeJlbno pacnaZjalOTCH HpHaeraiou rie TKaHH, KaTaCTpo(IIjIeC-
KH enHmalOTCH 3aERHTHhIe CHJr opraHH3Ma, yracaeT perenepaTHBHaH
CIIOCO6HOCT16 TKaHeH, H 06bILIHO B TetleHHe HOCHOJIbHIIX JjHOH pa3BH-
BaeTCH CerCHC. B jjpyrHX cJIyLIaHx HeRpOTH3HpOBaHHasI TKaHb OTTOp-
raeTCFI, Jje( eHT 3aMeuLjaeTcci rpaHyJIHIjHFIMH, a B JjaJIbHeHmeM-py61joM.
OTrpaHHileHHe MepTBOI'O ytIaCTKa IIpOIICXOJjIIT B pe3YJI16TBTe
J[eMapHaIjHOHHoro upoIjecca. Ocxosy ero COCTaB-
JIHeT IIpOTeWJIH3 B 3OHe COIIpHHOCHOBOHIIH IIOPH6IIIHX H MUBMIX TKaHeH,
OCyigeCTBJIFIeMbIiI (epMeIITaMH H3 TpeX rJIaBHNIX IJCTO4HIII{OB: a Y T 0-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JI H T H q e Ott H MR, CHHT03Hpy10IIuHMHCII IIpH pacuaAe THaHOH;
r 0 T e p 0 JI H T H m e C H H M H - IIpOAYKTOM ?HH3HeAeHTe3imH0CTH KTIeTOH,
aMHrpHponaBiuHx B Omar nocna IeHHH; r H C T H 0 J I H T H m e c K H M H,
CKOIIJIHIOIAHMNCH B OKpyHtHOCTH ceiBeCTpa B KamecTBe Beu;ecTB, BbI-
pa6aTbisaeMbix upHJIe)H mHMH H(H3HeCII0006HIIMH TKaHeBbIMH ane-
McHTaMH, a B AaJIbHOHIIieM - KJIOTKaMH rpaHyJIIIAHOHHOH TKaHH.
B pe3yJlbTaTe upOTeoJiH3a Ha rpaHHAe oMepTBeBHIHX H CMe?HHO 31e-
HcaMHX THaHeH BO3HHKaeT y3HHH ?HeJio6OK, aaUOJIHeHHbIH MyTHLIM
3HCCyJ(aTOM. B OKpy?HHOCTH ero, COOTBeTCTBeHHO CTeueHH peaKTHB
Horm Bocua3IenHH, pacuOJTaraeTCH HeCKO3ibHO B03BLIIIIaIOIIWHCH Ba-
JIHK rpaHynHpOBaHHH. CeKBeCTp OTAe2THeTCB OHOHmaTe3IbHO, KorAa
IIJIaCT rpaHyJIHAHOHHOM TKaHH IIOJIHOCTbMO IIOHp}IBaeT yueiiesmHe
TKaHH. IJIH aToro IIpH Heicpo3e KOHCH Ha 6OJTee HJIH McHee 3HamH-
TOJIbHOM IIpOTHHCeHHH Tpe6yeTCR CPOH B 10-14 AHeH. 3Ha'HTe3IhHO
MOATIeHHee OTTOpraIOTCH OMepTBeBIIIHe cyxo?KHJIHH, CB113HH, HOCTH.
OMepTBOHHe THaHeI3 Ha HOmBe CHJIbHIIIX TpaBMaTHmeCKHX HoBpe-
H{AeHHI3 XapaHTepH3yeTCfi mpe3BLImafHMIM pa3H006pa3HeM (opM.
B OCHOBe IIaToreHe3a HX TIeTh HT Ae3opraHH3aIZHH TKBHeH (pHC. 86),
coupOBOHV IOHca1Cfi r2Iy60KHMH HapyHleHHIMH HJTH ?ice IIOJIHWM
HpeicpauReHHeM KpOB006pau(eHHn. OTAeUbHMe (OpMII TpaBMaTH-
mecxoro HeHp03a maCTO Ha6TIIOAaIOTCH H Tpe6yIOT HeIOTOpOH AeTaJIH-
3aijHH.
PHC. 86. TpaBMaTH4eCHHH HOHp03 JTarni y C06aHH B pe3yJILTBTe
pa3M03meHHH HOJIeCOM aBTOMaiIIHitLi.
II 0 JI H 0 e 0 T A e Jt e H H e' TKaHel, He3aBHCHMO OT MexaHH3Ma
TpaBMaTHmeCHOro B03AeICTBHH (oTCemeHHe OCTpbTM HHCTpyMeHTOM,
OTpMB H T. H.), coupH?iceHO c HX rH6eJibio. TOJIbiO B OTAeJIBHbIX
c iymafIx ycuemHO upH?HHBa}OT JIOCKyTLI C He&3MeHeHHOH CTpyKTy-
pOH, IIOCTaBJIeHHbie B yCJIOBHf, IIpH HOTOpbIX IIHTaHHq HX BO00TaHaB-
JTHBaeTCfl B HOpOTKHH Cpoc. OCJIO?KHeHHe HH4IeH HeH HCicromaeT
Taicyio BO3MO)HHOCTb.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
C ,q a B JI H B a H H e TxaneIi iia ypOBHe KOCTHbIX BbICTynOB
y MHBOTHNIX, OCTalOII(HXCH AJ1IT0JIbHOe BpeM$i B JIC?KanCM nOJioH(e-
HIIH Ha TBOPAOM HOJIy, IIen36eHCHo HPHBOAHT H OMepTBeHHIO. Tai oe
nopaxcenne ITMexy}OT n p 0 JI e M H C M (decubitus). HpoJleurnu
B o6JIaCTH MaKJIoHosoro 6yrpa, pe6epHOIi CTCHKI H CYCTaBOB Ha6JIIo-
AaIOTCH oco6eHHo LIaCTO Y HfnBOTHLIX uCTOIAeHHbIX, nepeHOCIHuX
TAHCeJIble HHI)eHAIIOHHble 3a6oJleBaHHH, y cenTntieci nx 6oJlbnblx, npn
uoBpeHcgeHuaX CIHHHOPO Moira.
B 9THojiorugecHoM H IIaTOreHeTHMCCHOM OTHOHIeHnn H 3TOH me
4OpMe OMCPTBCHHFI OTHOCHTCH nOBpO}KA0HHH TKaHeli, noABepralo-
Pic. 87. HeI po3
ROMH (npoJIexceib)
OT J{aBJIeuHFI rinco-
BOI3 nOBH3EH.
iAuxeH CAaB3HBaHHIO nMMO61IJIH3yIOn;TMH n0-
BB31KaMn, IIJIOTHO o6HeralonWMn KOHeLIHOCTH
(pnc. 87).
IIepemII ypoBblBaHne HSryTOM
npH OCTaHOBKe KpoBOTetIeHnn, KOrAa OH *IPe3-
MOPHO 3aTBruBaeTCfl H HOnpCPLIBHO AaBHT B
TeLIenne HeCHOJIbHHx 'IacOB, BJIeLICT 3a co60I3
OMePTBeHIIe TKaneI3 OT YPOBIIH CAaBJIHBaHnfl Ha
BCeM HpOTHHKOHHH B HaupaBJICHIIH llepIII epHH
(CM. o6 ocTanoBKe KpOBOTeleHHH).
Y IIj 0 M JI 0 H n e TKaHen, KaH 4)aHTOp, o6y-
CJI0BJIHBaiouAuH OMepTBCHHC, LIaCTO I1M00T MOCTO
Hpn rpbllHax, 00011OBOPOTaX H y3Jloo6pa3OBaHH}JX
HHIHegHHKa. B 3T11X cJIy'IaHx B OCHOBO naTore-
He3a npoljecca JICHCHT HapacTalOHwee 3aTpyJjnenne
JIHM()OTOKa If OTTOHa BeHO3HOn KpOBII. IIepBO-
HaLIaJIbHO BO3HIK111Oe COCTOHHue 3aCTOII CMCHIIeTCB
B IIOCJIeAyIOIIWeM CTa30M. H IieMy npncoeAn-
HHOTCH ry6HTeJ1bnoe gOIICTBHO Ha TKaHH upo-
AyKTOB HCn3HeA0HT0JIbHOCT11 MnHPOC)JIOPhI HTIMOn-
Hnxa. IIpn co*IeTannn 3THX c aHTOpoB pa3BHBa0TCH
ranrpena yujeMJIOHHOrO yiiacTKa Knmii. B rpbn uax oua nepeAico
IT OCTnpaeTCH Tai Hme Ha THaHH rpblIJCBOPO McIHKa.
B OTAOJIbHLIX CJiy9aflx ynI0MJIOHne CJIyufnT nphI hIHOA OMCpTBe-
HHH noJio oro tljiefia. Y nJIOMeIIHbIX mepe61jOB, hCnOJTb3yCMbIX AJIfi
JCIJ CCTBOHHOPO OCCMOHOHIIH, oH0 Ha6JIIOAaeTCfl BCJIeACTBne cocuaJIb-
3bIBaHHfI pe3nHOBOrO HOJIblja BarnHbl H HCPCMII OBbIBannH 1OJIOBOro
' Ulena Bbllne BIIyTpOHHero npenyljwTH. Y co6aK cJIyLIaloTCfl TaKHe me
HBJIeHHH IIpH napaf HMo3e, HorAa TIOJIOBOII TIJIeH onJleTaeTCH AJIHHHbIMH
BoJIocaMi npenygnaJibnoro McIHKa.
H rpynne OMepTBeHHn, BbI3bIBaCMbIX MexaHHileCKnMII IIOBp01H 0-
HHHMH, OTHOCHTCH TaHHfe HOKpOTHLIOCKHC 113MOHOHIH TKaHen B OKpyHt-
HOCTH paH, KpaJ KOTOPbIX ilpe3MepHO CIIJIbHO C6JIHH{CHbI raBaMu;
OMePTBeHH0 1OA BJInIIHneM AJIHT0JlbHOF0 CAaBJIHBaHHH TKaHen Tyr14M1I
TaMHOHaMI, ApeHaHCaMu H APyF14MR IHOPOAHNIMI TCJIaMn; H0HP03
CJIH3HCTOII 06OJIOLIKn KHHIOH npn AJIHT0JIbHOM 3aA0p?H }IH Ha OAHOM
H TOM Hie McCTe IJIOTHbIX KOHKpeMeHTOB.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
06
00
C.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OMEPTBEHHE IIPH 3MBOJIHH H TPOMBO B
OMepTBeHHe THaHeH Y }KHBOTHIIX Ha IIOgBe 3aHyIIOPHH apTepHanb-
HblX H BOH03HLIX COCyJ OB gaCTO Ha6nIOJ{aeTcH Co CTOpOHII BHYTPeH-
HITX opraHOB, oco6exao HHIIIe'IHHHa, no eK H cene3eHHH. B BTHX
cjiyilaax HexpOTHilecKHH npoi;ecc o6'bgCHaeTcg pa3BHTHOM HmeMH-
gecRoro Him reMopparnilecKoro HH(IapKTa. l'H6enb THaHeii onpeAe-
neHuoro yuacTHa opraHa 6bi0Tpee HacTynaeT IIpH BM60RHH, geM IIpH
TpoM6o3e apTepHii HRH BeH. B HepBOM cnygae 3HagHTenbHOe Hapyme-
HHe IIHTaHHH THaHeH HacTynaeT cpaBHHTORbuo 6hICTpO, geMy cn0c06-
CTByeT TaK?Ke pefRelTOpHbII3 CIIa3M COCygOB. BO BTOPOM cnygae,
BBII Y 60nee McAneHHOro H HOCTeIIeHHoro 3aRpNNTHFi IIpOCBeTa cocyJja, ,
TOK KPOBH BHagane TORbHO ociia6eBaeT, HO He npeKpaII aeTCFI. HpH
TaKHX o6CTOHTeJIBCTBax KpOB0o6paujeHHe B o6eCKpOBneHHOM yiIaCTKe
HepejKo B03o6HOBnHeTCH, eCnH cyntecTByIOHjHe KOnnaTepanbHbie
IIyTH J(OCTaTOiiHO pacmlpHIOTCSI AO pa3BHTHA He06paTHMhIX J(ereHe-
paTHBHbIX H3MeHeHHH B TKaHfIX. CneJ[yeT, OAHaHo, OTMeTHTb, 'ITO
TaKOH HCXOA 6MBaOT nHmb IIPH oco6o 6naroIIpHHTHNIX yCROBHHX,
Korga KpOBHHOe ganneHHe y H{HBOTHOPO OCTaeTCH AOCTaTO'IHO BLICO
KHM, He H3MOHOIIbI B CBH3H C IIpeAiueCTByIOII;HMH 3aCT0IIHbIMH HBne-
HHfIMH THaHH II OTCyTCTByeT yrpo3a HH(HILHpoBaHHa.
Te pMHLIecKHM H XIIMH'IeCKHM II 0Bpe?HJ'[e-
H H H M, paccMOTpeHHIlM B pa3Aene o6 onwrax H OTMOpo?KOHHIIx,
HOKPO3 THaHeH COHyTCTByeT BO BCeX cnygaflx KpaTKOBpeMeHHOro
BRHHHHH CHRbHO J(enCTByIOIInHX areHTOB HRH IIPOJSORHCHTenb$oro
KOHTaHTa THaHeH C Beu(eCTBaMH, cna6o J(enCTByIOIIIHMH. 06yrnHBa-
HHe onpe)eneHHoro yLIaCTKa Tena Cny?KHT IIPKHM IIpHMOPOM cyxoro
HeIpo3a. OTMOpO?KeHHe TpeTbel CTeHeHII IIOLITH HeH36e?KHO OCnOxt-
HHOTCH rnI In HpoBaHIIeM nopa}KOHHblX TKaHeI3 H BcerJ;a IIpoTeHaeT
B (OpMe Bna?KHoro oMepTBeHHH (pHC. 88). Tan Ha3MBaeMMii Hap6o-
JIOBbIH HeKpo3, HHor) a Ha6RIoRaeMMI1 IIpH IIOnb3oBaHHH KOMIIpeCCaMH,
MaTepHan KOTOpIIX O6HnbHO HPOIIHTaH 5% pBCTBOPOM Hap6onosoii
HIICROTbI, Kan IIpaBHRO, pa3BHBaeTCH HO THIIy cyxoro oMepTBeHHH.
O norl IIIenOgaMH, Hao60POT, IIPHBOJ[HT R. BnaHCHOMY oMepTBeHHIO.
R rpyn a oMepTBeHHH BCReJKCTBHO Bo3Ae}CTBHH XHMIPIeCKHX
Ben(eCTB OTHOCHT IIOBpeH{AeHHH, o6yCROBROHHble IIPOHHKHOBOHHOM
B TKaHII ?He7IyJ;OgHoro H KHmegHoro COKOB, cenpeTa 110 ORyJ[O'HOH
nene3bi, a Tam?Ke o6HnbHhIM IIpoIIHTmIBaHHeM THaHeH MO'OH. Fy6H-
TenbHO geHCTByIOT HenOTOpble neKapCTBeHHLIe Ben(eCTBa, npeJjHa3Ha-
gaeMble J[nH BHyTpHBeHHOrO BBeJ(eHHH (paCTBOPN - xnopanrHI-
paTa, TpHHaH6nay, xnopIICTOro KanbI;HH H Rp.), BnuBaeMSIe no Hepto-
CMOTpy IIapaBacKyRHpxo.
B rpyllne TonCHgecHHX 3a6oneBaHHII, xapaKTepH3ylon-kHxcH He-
KPO3OM THaHeH, oco6oe McCTO 3aHHMaeT oTpaBneHHe MBTOgHIIMH
pox{KaMH (ergotismus). OHo Ha6RIoi aeTCH y IITHI[, CBHHeki, peace
249
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
y Kpyuxoro poraTOro cHOTa IT y JIomaj(eI3, xorga noeAaeMbme HMH
aepxosbie HJIH MygHHCTbie KopMa coAepn aT MHOFO CIIOpIIHbH. Ee
TOKCHgecKHe BeII[ecTBa (c(aIIeJIOTOKCHH, coHaJIHH-TOHCHH, XpH30-
ToI{cHH) AeI3CTByIOT HeRpo6HOTHLIecHII; nog BJIIIHHHeM HOPHyTHHa
OAHOBpeMeHHO pa3BnBaeTCH yCTOH'HBbHH CIIa3M COCyAOB; COgeTaHHe
O60HX 3T14X c aHTOPOB IIPIIBOAHT It CyXOMy Heipo3y, rJIaBHbIM o6pa-
30M IIepn epHgeCKHX OTAOJIOB TOJIa.
HexpoTHgecine H3MCHCHH1I THaHel H opraxoB HaXOAHT II1H MHO-
rnx HHC eKIjnoHHbix 3a6oJTeBaHHnx (nacTepeJIJIe3 ITTHIi, IlapaTH4
PHc. 89. OMepTBeHne ico rn
H HOAKO3KHOi3 KJIeViaTKH HpH
IJIerMOHe.
TOJIfiT H CBIIHeI, 3M()1H3eMaTO3HLIH nap-
6ynxyn, iyma CBHHOfi, nuxyp, Henpo6a-
I[HJIJIe3). B rpynne XHpyprri ecni x
HH(enI[HOnxbIx npoIrecCOB FIpHaf KapTHHa
He1POTHgCCHHX H3MeHeHHH OTMegaeTCH
npH rnouHOM TpoM6o4xlTe6HTe, KapHece
HocTeII, oCTeoMH3JIHTe, anaapo6Hoi3 H
rnnJIOCTHon HH(OHUHH, a Tal}Ke BO MHO-
?neCTBe ApyrHX CJIygaeB, Korja BOcna-
JIHTeJIbna1 pealcgHH 6ypHO HapaCTaeT II
pacnpOCTpanneTCH B TKaH}IX (pHC. 89).
B naToreHe3e HexpOTHgeCKHx H3MeHe-
HHn, HacTyiiaioir wx B CBH3H C IIHI eK-
AHOH, COgeTaeTCfi ry6HTeJIbHOe AeIlCTBHe
Ha TKaHH MH0 0 HCJIeHHMIX ianTOpoB.
R gHCJIy HX OTHOCHTCIT- TOKCIigeenne npo-
AyKTbI ?KH3HeAefITCJIbHOCTH IIHIJeKgnOH-
noro areHTa; TpoM603 HPOBeHOCHhIX
H JIHMIaTHgeCKHX COCyAOB, gaCTO IIPOCTH-
pafoHZHfica Ha 3HagrTeJlbnoe paccTOcIHne
OT OCHOBHOPO omara; HanonJienne B THa-
HfiX anecyAaTa, HHor a ra30B, CAaBaHBaio-
IAHX IIyTH 1PHToHa H OTTOHa KpOBH; ynagoK cepAegHOH Ae4TeJIbHOCTn;
Hapymennfi o6Mena BeIIJeCTB B pe3YJIbTaTe HHTOKCHKagHn opraHH3Ma
H paCCTPOHCTB HepBHOI3 CHCTeMbI.
CHMMeTPHgHan raHrpeHa, H3BOCTHa$T y JIIOAEH nog Ha3BaHHeM
60JIe3Hb PeiIHO, fIBJIIIeT IIpHMep OMePTBeHH1I in IIOgBe TpO(OHeBpO-
Tng~er~cKHX HapymeHHII. V ?KHBOTHMIX OIIa BcTpegaeTca peAKo (pile. 90).
cYTiOJIOrIH H naTorene3 3a6oJIeBarHH H:eAocTaTOgno BbIHCHeHu.
CgHTaIOT, tITO B OCHOBe ero JIesxaT pacCTpOHCTBa B 3HAOHPHHHOI3
CHCTeMe, BEI3BaHHLIe (JyHKI;HOHaJIbHTAMH HapymeHHHMH BMCfIX
IIeHTPOB HpoB006pa1I dHHfi. OpraHHgecnn Ji3MOHOHnJ CO CTOpOHdai
MO3ra He o6 Iapy rniBaeTCH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
9TOMy IIporteccy KnorZ(a npeAmecmyio1 -t n$eJIbie HH(OKL(HOHHbie
3a6OileBaHHFi. V nioj;eH B OTAenbHbix cJiyilaSx CUMMOTPH'qHOe OMepT.
PHC. 90. CHMMeTp1asas raurpeHa.
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HeH OTMeqaeTCH MpaMopabin pHeynox.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ho3HHe, IIpg gJIIITeJIhHOI3 IIfOMIIII Heprn epiLIecilx yLIaCTHOB,
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
pereHepauHH, HyH{HO oco60 OTTeHHTh anatleHHe Cl00060B H CPO CTB
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Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HOMA (NOMA)
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HJIH HHOH CTeUeHH o6eao6pa}KHBaIOT HfHBOTHOe H MemaioT HpgeMy
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B OTAOJIbHMIX cJiytianx npoTenaiOT HapaBlle C HBJIOH11HMn pacnaga.
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IIyXJIOCTb c ia60 Bbipanfena H JIHIHb no Kpaio H3BLI. B 30HO oe pacnpo-
cTpanenHH HaXOAIITCH o60AOH 311ITeJImaJIbHOro npoJln(epaTa C =ICTKO
BbIAOJIHIOIueIICH rpaHiii eiI. II03AHee HOBoo6pa3OBaiinbH3 IIJIaCT 3IIn-
TeJI11H pacnOJiaraeTCH Ha OCHOBO 113 yIIJIOTHOHHOrO, nocTenenno CMOp-
IIZnBaionlerocn coeAniinTeJIbHOTKannoro npo1m epaTa. BcHKaa giIn-
TeJIbHO He3a?KHBaIOnjan pana M0)IOT HpespaTnTbcH B IIPOCTyIO H3By
(CM. BbIme o 3aMeAJIeHnn npouecca 3a?K11BJIOHf1 paH).
Oco6emIHOCTbIO rpaHyJIHu110HIIOii TKaHn, pa3paCTaIon encn IIpn
113'bi3BJ1OHn11 y ?KHBOTHbIX C ocJia6JieHHoI CepAeuHO11 AeHTeJIbHOCTbIO,
a Tan?ne npn o6pa3OBaHnn H3B B yqacTKax TeJIa, rAe AJI11TOJIbHO
Hapymen 0TTO1 BeH03HOHH KpOnn, CJIy?KiT 00 OWe IHOCTb. TaKne rpa-
HyJiHunn pbIXJIbI, a B COCTOHII1111 HPKO BbipameHHoro OTena - CTy-
AeHnCTM, Apn6JIbI. Hx mnAKOe CJIn3nCTo-rHOiiHOe oTAeJIHeMOe IIO-
CTOHHHO OMbIBaOT 1OBepXiiOCTb H3BbI, B 6OJIbIIIOM KOJI1LIeCTBO 06Hapy-
?KlBaCTCH B CO o1py?KHOCT1 n o611JIbHO IIponmTbinaeT MaTepnaJi
nonH3Kn. 3II11TeJI113aunn B 3TOM CJIyhIae, BCJICACTBne riApaTaunn TKa-
HOBOH OCHOBbI, gpe3BbFiaf1HO 3aTpyAHeHa.
TKaHeo6pa3oBaHne CnJIbHO HapyiuaeTCH, KorAa B Te*Ienne AJIn-
TeJIbHOTO nepnoAa cyiueCTBOBaH11H Ae(enTa B OCHOBaH1111 ero pa3-
paCTaeTCH TOJICTbIII, yIIJIOTHeHHbin ( H6po3HbIH IJlacT (K a JI TI e 3-
H a q H 3 B a). FpaHyJIHIInOHHan Maim Ha ero IIOBOPXHOCT14 cJia6o
BacnyJIHpn3npoBaHa, 6JIeAHOpo3oBan. IIpn OCMOTpe HOBOOpy?KeHHbIM
riia3on OHa npeACTaBJIHeTCH rjiaAnoii, JInmeIIHOi 3OpHICTOCTn.
CKapnc nunpyn, CJIOYI ee TOJIIuIIHOiI He 6omme 1-2 MM Jierno yjaeTCH
oTAeJIHTb OT noAJIemaiueiI TKann. TaKne me oco6ennoCTn Ha6JIio-
AaIOTCH CO CTOp0Hbl rpaHyJlnunoHHOii TKann, nOKpMMBaioiuei3 y9acTKn
n3'bn3BJIeHnn npn CJIOHOBOCT11.
B oTAeiiax Teiia, *ianle Ha KOHO4HOCTHX B MOCTBX npoxomAeHnn
1OABHMHbIX CyXO?KnJI11n, npn H3BaX o6bl`IHbIM HBJIgOTCH pa3pacTaHue
rpaiyJinuniI B CJ)opMe MaCCHBHbiX rpn6oBuAHbix BbITIHLIIBaHnH
(pnc. 91). IIOHBJIHIOTCH 0x11 ncJIeACTBne HOBTOpnoro TpaBMnpOBaHHH
IIOCTOFIHHO cMeiuaioiunxc1 TKaxeil. Ho o6nbie pa3pacTannc (taro
luxurians - ) MoryT 6bMTb Bb13BaHbI H ApyrnMH pa3Apa-
mnTeJIfIMn: CeRBeCTpaMBI, McJIKIMII 11HOPOAHbIM11 TeiiaM11, rHO11HLIMI
cxonJleHn}MH 11 T. A. TaKne rpanyJiaunn o6JJIbHO BacHyJlHpn3npo-
BaHbI. OHn ApH6Jrbi, JIOMKn BcJIeACTBne Aereuepaiuin (mnpoBOe,
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
6eaKOBoe IIepepox{AeHHe) H HPOBOTOHaT IIpH CaMOM He3HatIHTeJIbHOM
TpaBMHpOBaHHH.
BTOpgtIHaH HH4leHIgHH, tIaCTO IIpHcoeAHHHiOIIgaaca B CBH3H C IIO-
CTOHHHIiIMH MexaHr'IeCKHMH pa3ApaH{eRHHMH, yCyry6JIHOT Te*IeHHe
H3BeHHoro IIpoi ecca. B pesyJlbTaTe BCIIbIIIIHH BodnaJIeHHH paCna-
AalOTCH HJIeTKH, KOTOpble AO 3TOrO 6biJIH MH3HednOco6HIaMH HJIH
HaxoAHJIHCb B COCTOHHHH HeHpo6HO3a. BMeCTe C TOM napaCTaiougai
HH#JIbTpaL HH THaHe1 B OKpy}KHOCTH H3BbM, 6oJIe3HOHHOCTb, CoCy-
AHCTble paCCTPOHCTBa IIOpo}R aIOT HOBBIe yCJIOBHH, CYIAOCTBOBaHHe
KOTOpbix coIIplH{eHO C TPOi1II1 CCKHMH HapyIIIeHHHMH. IIpH TaHHX
06CTOHTeJIbCTBax IIporeCC IIpHo6peTaeT oCo6eHHOCTH
l
!
aregcHHti ecKOI3 H3Bbi (phagedaeni- a
'
pa-
cus - C1KJIOHHMI3 H OMepTBeHHIO H pacnagy). I
HyJIHIgHOHHaH THaHb yCTHJIaeTCH MyTHbIM, cepoBa-
TbIM HaJIeTOM, OMbiBaeMbIM 06HJI16HLIM-0 MHAHHM
rHOeM.
Pacuag TKaHei3 IIporpecclpyeT, Horga H3BOO6-
pa3OBaHHe 06yCJIOBJIeHO BJIa?HHOI3 raxrpeHOli H TH-
x{eJIbIMH HapyIHeHHHMH B opraHH3Me (cenCHC, rJiy-
6oxaH alleMHa, pacCTpOIiCTBa o6Mexa, HcToIIgeHHe).
FpaHyJIHIgHOHHI.lii HOHpOB Ha H3BO OTCyTCTByeT;
nopa)HOHHbie THaHH IIOHPMTN 6eccTpyHTypHOii pa3-
H{H}HeHHOH MaCCOH, B KOTOPOH xopomo 3aMeTHhI
MejIHHe H KpynHble o6pMBHH IIorH6MHx IIytli{OB
BOJIOHOH, oro1IeHHbie cyxo EHJIHH, CBH3HH, HOCTH,
McCTaMH CTBOJIMI COCyAOB H HepBOB.
Pa3Mepbl H3B, B 3aBHCHMOCTH OT HX JIOKaJIH-
3algHH, 3THOJIorHH, MexaHH3Ma Ae13CTBHH IIPHtIHHHMIX
IaKTOpOB, HOJIe6JII0TCH OT BeCbMa McJIHHx, Tpy)HO
onpegeJIHeMbix HpH OcMOTpe, 90 o6111HpHbix, Korga
THaxeBMfi ge(eHT H3MepReTCH AecHTI{aMH HBagpaT-
HbIX CaHTHMOTPOB. B3Bbi orpaHHtleHHlix pa3MepoB
tlaCTO Ha6JIIOAalOTCH Ha por0BHtge, CO CTOPOHBI CJIH-
3HCTOI3 06OJIOtIKH gbixaTeJIbHbix, IIHIIgeBapHTC ThHhIX
PHC. 91. IIbim-
Bbla pa3POCT
rpaHynHlgHOH-
Horo noxpoBa
H3BMI.
H MOtIeIIOJIOBMIX HyTel, a TaHH{e 3HgoRapga. B rpoMaAHeI ueM 60JIb-
IIIHHCTBe cnytlaeB 3T0 H3BhI C H M II T o m a T H tI e c K H e, CBOA-
CTBeHHble MHOrlM HH4IeHIgHOHHMM 3a60JIeBaHHHM H{HBOTHbIX. TaHHe
H3BbI, Ha} IIpaBIJIO, MHO}KeCTBeHHUI H 3atiaCTyIO HMelOT xapaKTepHbie
1111 oupeAeJleHHOr0 3a6oJIeBaHHH (OPMy, Rpm, AHO: Kpyrllbie,
3Be3gtlaTme, 6JIIOAIgeo6pa3Hble H T. A. (AaHHMe O HHX H3JIaraIOTCH
B Hypee 3HH3oOTo orHH).
IIpHBegeHHaH Mop1o1IOPHtledKa1 xapaKTepHCTHKa OTHOCHTCH H TaK
Ha3hlBaeMbIM H A H O II a T H tl e C H H M H 3 B a M, B03HHKaIOIWJM
BOJIeACTBHe OCJIo)HHeHHH HH(eRlwHeu TpaBMaTHt1eCHHX HoBpe}KAeHHl3,
riponeH{Heg, o3Horon, 0TMOpOH{eHHH H T. A. OHH MoryT 6hITb pa3JlHtl-
HOII 4IopMM H pa3MepoB, C POBHUIMH HJIH BOJIHHCTNIMH HpaRMH,. c rJlaA-
KHMH HHH HOApBITbiMH CTOHKaMH. a3TH CBOiiCTBa HAHonaTHtieCKHX
H3B 3aBHCHT OT OCO6eHHOCTeg nopameHHl3, HpegmmeCTBOBaBHIHX.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Ilenpo3y, a TaRHCe OT COIIyTCTByIOIIjHX ocJlo}KHeHHn. HanpHMep,
IIOCJIO OTTOPmeHHH MyMH(114AHpOBaHHOH HOH{H IIpH IIpone?KHe OCTaeTCH
6JIIOAIjeo6pa3HaH H3Ba; Korga go oMepTBeHHH Roma 6MJIa OTCJIOeHa
n o6pa30Bajicq JIHM(03HCTpaBaaaT, HeH36emHo noHBJIeHHe H3BiI
c 1OJjpbITIIMH KpaaMn. Ee Ha3bIBaIOT C H H y 0 3 H 0 YI. YCJIOBHH
gJIH (opMnposallnH HOA06HOI3 Fi3BhI IMeIOTC$I TaH}f BO Bcex CJIy-
ganx pa3BuTnH 1H(f eRijnn B noAHOSHHOI3 KJIeTgaTHe Ha ypoB-
He HOCTHbIX BMCTynOB. 3geCb HeHpo3 i on n no McXaHH3My np0-
JIe1KHH conpoBOmgaeTCH o6pa3oBanneM mnpoHHx IIOj(KOHCHLIX Hap-
ManoB.
llpOrIIO3 OTHOCHTeJII HO 6JIaronpHHTeH IIpH IIpOCTOn H3Be. OAHaio
IIp1XOAHTCH CgHTaTbCH C B03MOMHOCTLIO ee OCJIOHfHeHHf B Bnge Tpe-
IIuHH (rhagades) Ha py6I oBO H3MeHennblx noxpoBax yxce 3a}KUBIIIHX
H3B (LIaCTO Ha6JIIOgaOTCH Ha crn6ax CyCTaBOB), MaCCHBHbIx pa3paCTaHgn
(H6p03HOI3 TKaHI, yMOHbI4aIOIIjHX IIOABHHacI~najnHme JIIICTHH
B o6JIacTH naJIbl[a JiomajSH.
XpHH[OM, OHH o6JIertIaIOT CHOJIbHie-
HHe cyxo icHJIHFI 11 CB313OK B rpa-
HHuaX HopMaJIbllOH IOABIIMHOCTH
COtIJIeHOHHH.
TaHoe 4JyiiuiwOHaJIbHOe Ha3Ha-
TIeHHe CHHOBHaJlbHLIX CYMOH HpeAo-
npeAeJisIeT Hx iOpMy H IfpoTH?Ke-
HHe, 60Jiee HJIH MCHee yCTanoBHB-
Blnecg B HpoiieCCe aBoJIIOIurn: OHI3
HPOAOJIPOBaTbI B MecTax, rAe THalH
HpH JABHH HHHX HIHBOTHOrO cMe-
uAaIOTCFI B 3Ha'IHTeJlbxbix rpaHHl[ax,
H of pyrimi HOA Ma1IOHOABHHiHbIMH
CyXO?KHJIHHMH H CBII3iiaMH.
B CTeHlfax CHHOBHa7IbHbIX CYMOK
THaHH pacrouaraioTCH AHI4epeHiuH-
poBaHHbIMH CJIOHMH: BHYTPOHHHH
HOHPOB IIPeACTaBJIeH CHCTCMHO yJIO-
H OHHbIMH Me3eHXHMaJIbHLIMH HJIeT-
HaMH; Hapy?ICHbII3 CJIOA, HpuJie?ICaui[HI3
H CMe1HHbIM THaHHM, COCTOHT 113
HJIOTHOH BOJIOKHHCTOH 0009HHHTCJIb-
110H T1aHH; MC?i;Ay HHMH JI0m14T
pbIXJlblH CJIOH TOHHOBOJIOIHHI7CTOH
TICaHH. CJIOHCTOCTL CTCHHH XOPOIHO
Bbipa iieHa B ytiaCTuax ee, npHMbI-
HalonmHX H COCeAHHM pfIXJIbIM Txa-
HHM; OHa nOCTeHCHHO TCp}OTCfI B nepexo ax Ha xpsi11enoii noxpoB
HOCTIILIX BbICTyHOB, a TaHme Ha cyxomffjine, Ha Ty tiaCTb er0, HOTO-
pau HOCTO$IHHO ConpHHacaeTCJI C xpsn I eBOI3 HOBCpXHOCTbIO.
MHorHe CHHOBHaJlbxble CYMHH Y Bcex MRBOTHbIX OnpeAeJIeHHOPO
BHAa coo6HjaIOTCH C noJIOCTHMH cycTaBOB, HOHOTOpble Hie HMeIOT TaRHe
HOMMYHHHaILHH TOJIbHO B OHpeAeJleHHblx cJiytiafx. Peme cyMHn coo6-
HlaIOTCSi C HOJIOCTHMI CyXOH lJIbnbIX BJIara2Inw, pacnOJlo?HeHHLIX B TOM
?ire cJIOe TifaHen. HaJintIne TaHHx HOMMyanHagiiii C CyCTaBHOH HJIH
cyxo?IfHJIbnoBJIaraJIHwHoi3 IIOJIOCTbIO AaeT OCHOBaHHe noHlaraTb, 'ITO
COOTBeTCTBYiomafl cyMxa CBSi3aHa c HHMH B reHeTHMOCHOM OTHOHIOHHH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CpeA14 cIIHOBHa16HLIX cyMOK HaH6oJlee uaOTO nopa?HalOTCH: Me3K-
6yropxoBaH - Hog AByrJIaBMM MyCKyJIOM HJIe,Ia, nogcyX01KHJT6HaH
aaocTHoro MycHyJla, cyMKa o6n.ero (AJIHHHOro) naJlbljenoro pa3rH6a-
Tensl - Ha YPOBHO IIyTOBOro cycTasa, 'IeJIHOLIHaH - nog KoHAeBOI3
nacTmIo rJIy6oxoro naJlbgeBoro crH6aTeJIH.
CyXO,KHJIbHIIe BJIaraaHma HpeACTaBJIHIOT co60II
cTIOH{Hble yAJIHHeHHIIe ITOJIOCTH TaKoro me ( yHKAHOHaJIbHOPO Ha3Ha-
neHHH, Ka1 H CHHoBHaJlbHLIe cyMKH. Ha ypoBTIe cyczaBOB 0H14 oHy-
TaHMI I acI;narIbHLIMH JIHCTKaMH (pHc. 100). HpoHdHMaJIbHO, Hag cy-
PHc. 101. BbIBOpoTbl
nanbueBOro cyxoxcHJib-
Horo BJlaranaiga.
Mae. 102. Me3oTeaonM CYXOMnJInH
ray6oxoro nanbueBoro crH6aTensi.
cTaBaMn,,KapMaHM CIHOB14aJIbHOH o6oJIOLIKH JTe}KaT Ha 3HaMHTeJIbHOM
HpOTHH{eHHH B pMIXJIOH TKaHH H B HeHOTOpbIX CyXON{HJIbHbTX BJlara-
alligax o6pa3ylOT BUIBOpOTLI, Hanogo614e CyCTaBHLIX (pHC. 101).
LHCTaJTbno TaHHO BMnfiLIHBaHHH cHHOBIIaJIbx0I3 o6oJTOiIHH McCTaMH
npoHHKa1OT B TOJIMy KJTeTLTaTKl 'Iepe3 y3KHe IAeJTH B (acgHHx. Cyxo-
H LJ1IIH, npoxo cImHe Ha 60JIbIner 14JI14 McHbIneM paCCTOcTHlH BHYTPH
HOJIOCTH, HOKpIIThIe BHCI;epaJl16Hh1M JIHCTHOM CHHOB14aJTbHOn 06OJIOLIK14,
CHa6H eHM 6pb1H{eMKaMH (M e 3 o T e H 0 H) B (lopMe BHyTpHIIOJTOCT-
HLIX AyrnrHKaTyp CHHOBHamlbnoro nOKpoBa. B H14X HpoxoAHT cocyghI,
o6ecnegIHBaloiAHe KpOBOCHa6}Kenle H 0TTOK JTHM(Ll B 3TOM yuacTKe
cyxox{HJIHS (pHc. 102).
B McCTax cROJTLSKeHHH cyx05KHJIHI3 Ha ypOBHe KOCTHLTX BLICTyIOB
BHyTpeHHHH HOBePXHOCTb CyxOH{HJIbnbNX BJIaraJJI1U niagKaH; y BLT-
BOpOTOB MO, B HX. IOJTOCTS1X H Bo ncex gpyrnx yTacTHax, rge OTCyT-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BTbyeT 1 aBJiemie co cTopoHbt cyxoxtHJiHA, OHa $OpCHH'l1Ta H HMeeT
CJIOHSHyIO CHCTeMY IIpiICTeHO*IHTIX gyIIHHHaTyp CHHOBHaJIbHOH o6o-
JIOiIHH. B OTAeJIbHMX CyXO?HHJIbHUIX BJIara2IHigax, HanpHMep naJIH e-
BOM, BCTpeiIaIOTCH, HPOMO Toro, BHyTpHIIOJIOCTHLIC CHnaAHH, pa3Ae-
JIHIo1I;He HapMaHbl IIOJIOCTH BO ( pOHTaTIbHOH IIJIOCKOCTH.
BocnaJIHTeJlbHble npor eccbl CHHOBHaJIbHbIX CYMOR H CyXOH{HJIb-
HbIX BJIaraJIHIIr Bo3HIIHaIOT IIpH B039OHCTBHII TeX me (aHTOpOB, -ITO
H B CJIH3HCThIX cyMHax (ymIi6bi, paHeHHH, paCIIpOCTpaHeHHe iIH(HJIb-
TpaTOB CO CMCHHHhIX TKaHel3). BMeCTe C TOM B pa3BHTHH BocnaJleHHI3
3J[eCb oco60 Baxcnyio pOJIb HrpaIOT H3MCHeHHH B CaMHX CyXO1KHJIHHX.
Tame COCTOHHHH, Har paCTH}KeHHS H pa3pbinbl Hx B ytiacTKe CHHO-
BHaJIbxoH CyMHH HJIH CyXOMHJIbnoro BJIaraJIHH;a, HeH36eH(Ho BJIe-
HyT 3a co6oI3 pa3BHTHe BOCnaJIHTeJYbxoro npoljecca co CTOpOHbI CTeHKH
cOOTBeTCTByIOHrei3 IIOJIOCTH co CKOIIJIeHHeM B Hei3 cepo-(H6plno3Horo
aHccyAaTa.
Oco6eHHocT161o CHHOBHanLHbiX o6OJIO9eR HBJIHeTCH HX BblcoIan
LIyBCTBHTeJIbHOCTb IIpH CeHCi36BJIH3agHH opraHg3Ma. B CBfi3II C 3THM
OHU Hepeju o nopa?KaIOTCH McTaCTa3HpyIou(en moihiOH IIH()ei1[IIeI3,
IIaH;e CTpeuTOKOHKOBOH.
CUMHTOMbI n j{garHOCTHKa
OCTpoe aCeuTH'IeCHOe noenaJIeHHe CHHOBHaJIbHbIx CyMOH H CyXO-
MHJIbHbIX BJIarairaux COIIPOBO?H)[aCTCn xopomo 3aMeTHOH CMemaHHOH
xpOMOTOH. (BocuaiieHHe *ieJIHOTIHOH CyMHH IIpOTeHaeT C HapyIHeHHeM
4 yHH1[HH onopbl.) B IIOHOe MHBOTHOe JxepafHT KOHetIHOCTb B IIOJIyCOPHy-
TOM, paccJla6JIeHHoM COCTOHHHH. B HoBpeMgeHHOiI o6JIaCTH o611apy-
HHHBaeTCH pa3JIHTaH IIpHIIyxJiOCTb. HaJIbIIaTOPHO yCTaHaBJIHBaIOTC1i
6one3HeHIIOCTb H IIOBLIIIIeHHe MOCTHOH TeMnepaTypbl. WJIIOHTyaIUIH
JIerHO OllpeJ{eJIHeTCH IIpH HauOJIHeHHH aHCCygaTOM CHHOBHammbHbix
CyMOH H CyxoH{HJIbHiIx BJIaraimm AHCTaJIbHoro oTJAena HoaegiioCTei3,
rge OTCyTCTByIOT MaccHBHHIe HJIaCTb1 pbiXJlblx THane13. Hao6opoT,
y uOHCOB, HaHpHMep B o611aCTH rJle'e-JIonaTOLIHoro CycTaBa, HanoJl-
HeHHe CHHOBHaJIbHTIX CyMOK 3HCCyj;ATOM BbIHBHTb 3Ha'IITeAbHO
TpygHee.
B xpoxggecKOi3 CTaj;HII acenTH'Iecxoro BocnaJIeHnn HCHO BMIpIICO-
BLIBaeTCH HanoJIHenxag IIOJIOCTb, rpaHHqbi ee g0THO KOHTypnpoBaxbl
(pnc. 103). HocJie HyHKIIHH H BBaEyaixHH ?HH)[Horo axccy iaTa B IIO-
JIOCTH BO MHOrHx CJiyqaax y) aeTCH npomynaTb HOMHII (J)H6pnna,
j(ocTnralomne BOJIHqHHhI JIecHoro opexa (H 6onnbme). B cyxo?HHJIb-
HbIX Bnaranlnuxax oHH Beer) a pacnoaaraioTCH B BepxHHx HapMaHax,
o6bl'HO paClIIHpCHHLIX B ATOM HanpaBJIeHHH (pHc. 104).
OTJIPILIHTOJIbIIOA oco6exnocTblO xpoHHLIecHHx aceIITHi1eCKHx BOC-
na7IeHHi3 cHHOBHaJIbHMIX cyMOH II cyXO?KHJIbHUIX BJiarairnn, B COHO-
CTaBaeHHH C HOJ O6Hb1MH Hpor eecaMH BO MHOrHx IIOBePXHOCTHUIX
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CJIHBHCTbIX CyMxaa, C I HT cpaBHHTeJIbao cJla6as IIpwi$epaiurn
COOAHHHTeJIbHOH TRaHH B HX OKpy}HHOCTH.
Rorra BOIIpOC xacaeTCH CHHOBHanbHEZX CyMOK, IIPH AHarHOCTHR
Ba7KHO yCTaHOBHTb, CyMeCTByeT HJIH OTCyTCTByeT coo61I.eHHe C COOT-
BeTCTByIOII;eH CyCTaBHOH IIOJIOCTbIO. HanHtiHe KOMMyHHHaIIHH IIOp(TBep-
xfAaeTCH BHagHTeJIbHbIM HanoJIHeHHeM nonOCTH CyCTaBa IIpH OJjHOBpe-
McHHOM yMeHbmeHHH HOJIHqBCTBa
aKCVj;aTa B CyMKe B MOMeHT ee
CgaBJIHBaHHH; IIPH IIyHRI;HH H
aBaRyaI;HH COjjep ffHMOro CyMKH
OAHOBpeMeHHO ocna6eBaeT CTe-
neHb HauOJIHeHHH KancyAM Cy-
CTaBa; C HaAaBnHBaHHeM B yHaCT-
PHC. 103. Br1IIHgH- PHC. 104. PacIIrH-
BaHHe cyxoufHnb- peHae BepXHHX Bbr-
Horo Bnara.1mn(a BOpOTOB Cyaoxfanb-
IIpH apoHHtlecxoM HorO Bnarannu a.
aceIITHYecHOM BOC-
IIaneHHH.
Pac. 105. IIonoxfenHe HoaegHOCTH
B noHOe upa bursitis trochanterica.
Kax CYCTaBHTIX BBIBOPOTOB yCHJIHBaeTCH TOR aRecygaTa trepea Ranronio,
KOTOPOg IIyHKTHpOBaRa IIOJIOCTb CyMKH. LnH YTOtiHeHHH BOnpoca
MO?HeT 6LIT16 HCIIOJIb3oBaHa Tan ne peHTreHorpa(HH IIOCJIe BAYBaHHH
BO3Jjy%a tiepea Hrny B OZ[Hy Ha 9THX HoJIOCTe i (B. A. HHRaHOpoB).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
cDyHIa noxaJlbHble HapymeHHH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HaucyaLi H CB03OH HeuocpegcTBeHHO Y IIepHOCTa. PaHHHe IIpHaHaKu
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Hoaxte, c HepexogoM 3a6oJIeaaHHH B xpoHHgecxylo 4OpMy, OT-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BOJ;KH. 3THM11 CIIOco6aMH B CBe1KHX c iygaHX ygaeTCH J;OCTHgb HCgea-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Tpo(f)H`IecI.uii CBH3H XpHHja C I{OCTbIO, HacTyuaIoiuee BCJIej[CTBHe
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TxaHlIbix HJIOTOH, B TOM LIHCJIC H OCTeOHJIaCTOB. B McCTax HX Cr{oII-
JIeHnu, BCJIOJ[CTBHO Jjel{aJIbIjHHaruIH n pacnaJ[a xOCTHbIX IIJIaCTHHOH,
o6pa3yIOTCH McJIHHe IIOJIOCTI. Taxoi IIporjecc HMeHy1OT p a p e-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
~HIiHp y1019HM 0CTHT0M, a HO THaHeBbIM H3MOHeHHHM-
JIaI yHapH0li pe3op6H;HeA, HaH ocTeoH0 poa0M.
C BO3HIIKHOBeHHeM ero Hagr HaeTC$ 6onnee HHTeHCHBHBIII pacnlaR xpR-
n[a; BO MHOrHx yilacTFax, rHIaBHbIM o6pa3OM B IReHTpaJTbablx, no-
HBJIHIOTCH y3ypbl H oroJHHeTCFT no;xjieHfaU aR HOCTHaHH THaHb. 3TO -
oCHOBHble H3MeHeHHH THaxen B HepBOH3 CTajjHH OcTeoapTpHTa. Bo
MHOrHx cJIyLIaax HpHLIHHOi3 Hx CJIyHaT yfH6bI CyCTaBOB BO BpeMH
PHc. 111. H3MeneHHST
HJIIOCRb n PH XpOHH-
gecxoM Aeq)opMHpyIO-
meM apTpHTe HH EIIero
oTJjeJIa cxaxaTeabxoro
cycTasa.
PHc. 112. HocTHble H3MeHeHHH npH
Ty6epxyne3HOM apTpHTe cxaxaTeJlb-
HorocycTasa y Hopoabl.
npbI)KHOB, HpyT IX HOBOpOTOB, CTpeMHTeJlbHbIx ocall{HBaHHid ?HHBOT-
Horo H T. n. B xageCTBe BTOpkgIHoro HBJICHHH Ha6JIIOJjaeTCH yTOJIIE eHHe
CBH3OH H I?a6poanoro JIHCTKa CyCTaBHOI3 HanCyrnI. B ) aJlbHel3-
meM upoIJece xapanTepH3yeTCH McJTTeHHbJM 0 C T e o c H a e-
p 0 3 0 M - yTOJHIIIeHHeM HOCTHIJX nepeximAHH, c6JHH?HeHHew HX,
yMeHblmeHHe1 KoJIHLIecTBa u o6'beMa HOCTHOM03roBhix HqeeH B uo -
xpHIAOBOM CJloe H B oHpyll{HOCTH JlaxYH. 3Ta BTopaa CTaAHH npo-
I;ecca B HOCTHOH THaHH - ICONAeHCHp y IOII;I1H OCTH T-
pa3BHBaeTCH OAHOBpeMeHHO C occJ4MlHaI;HeI3 CBH30H H McCTaMH
xancyJlbz cycTaBa. Y3ypbl xpaa a 3auOJIHHJOTC$i rpanyJIHIJHOHHOIF
TxaHMo, pa3paCTaloWeIICH Co CTOPOHN xoCTH. B noc11euyIOll;eM 3Ta
T} anb npeBpaaJaeTCH B (116po3Ho-xpameByIO, rHaJIHHH3HpyeTCH H
o6ecuegaBaeT AOCTaTOLIHy1O IIOJ;BH?aHOCTb cycTasa;
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
AHHHJIO3, Hai cJIeACTBHe oCTeoapTpl3Ta, gauge HacTynaeT B McJI-
HHX, orpaHHLIeHHO IIOABHxcHbiX cyCTaBax, HorAa pacnaA xpfin[a IIpo-
cTHpaeTCfl Ha 6oJlbmoe IIpocTpaHCTBO, 3axBaTMBaH nepHCj)epHUecxge,
Hp1MhIHaIonkHe H nepnoczy ygacTHH, H OHOCTexeBalOT 110 BCeII
AJIHHe HOpoTHHe CBH3HH TaHHx CycTaBOB, BBHAy *iero OHOH iaTeJIBHo
fMMO6HJIH3yIOTCFi COOTBeTCTByIOIgIIe 3TamH HOCTeII, HanpHMep Tap-
3aJI16Horo CyCTaBa.
ApTp03 H OCTeoapTpHT Bbl3bIBalOT IIOHH?HeHHe yCTOIitIHBOCTH Cy-
CTaBHbIX OTAeJIOB HOCTOH H Bo3AeIiCTBHIO 06bILIHOH c H3HOJIOrwieCHoii
Harpy3HH. Bo BpeMfi TH?He7Ioii pa60Tbl IIpH TeX Hfe yCJIOBHHX, HOTO-
pble IIpHBeJIH H 3a6oJleBaHHlo, c pacnaAOM xpama B IleHTpaJIbHbIx
y,4acTHax cycTaBHbIx noBepxnoCTei3 ycHJIHBaeTcsi AaBJlebne Ha ne-
pH(epHH cycTaBH1Ix njiouxagoH. 3)xecb pa3BHBaIOTCFI TaHHe me
H3MeHeHHH HOCTHOH THaHH, OAHaHO C TOH 0006eHHOCTbIO, 'ITO B BOCIIa-
JIHTeJIbHbII3 IIpoi eCC BOBJIeHaeTCH OHOJIOCyCTaBHOH yiIaCTOH HaAHOCT-
HHB;bI, a BMeCTO C Hell H HaIICyiia CyCTaBa. Tafcir o6pa30M, H OCHOB-
HOMy HpoUeccy B HageeTBe BTOpIILIHoro fIBJIeHHi npHCOeAHH1eTca
xpoHHT-IecHHIi OCCHC lnUHppoigii i IIepnapTpHT. B pe3yJIbTaTe pa3pa-
CTaHHH HOCTHOI3 H j16po3HOii THaHH B COOTBeTCTBy!on eM MOCTO
BLICTynal0T naTOJIOrHqe6HHe BbinxwinsaHHfl, o6e3o6pa)HHBaioll;He
cycTaB. TaHOB B 6oHbIHHHCTBe cnytiaeB rene3HC npor ecca, HOTOpOMy
npHCBOeno HaHMenoBaHHe - x p o H H LI e c H H Ii g e( o p m H-
P Y Io n[ H ii a p T P H T (pile. 111). OH Ha6JIIOAaeTCH BO Bcex CyCTa-
Bax, oco6enxo ,iaCTO y JIOmaAeli H pa6ogHx BOJIOB. Y co6aic nM He-
peAHo nopa f!aeTCJI Ta3o-6eApeHHblii H JIOHTeBOI3 cyCTaBbi.
HOMHMO 3Toro, YaCTbIMH IIpiLIHHaMH 3a60JIeBaHHn CJIy?HaT paCTH-
?ieHHH CyCTaBOB, IIOBTOpHhIe yfH6m, BHyTpHCyCTaBHbie IIepeJIOMbI,
BLIBIIXH. ,,e4 opMHpyion;Hi3 apTpHT - HeH36emHoe cJIeACTBHe rbOli-
Horo apTpHTa, pe9HAHBHpyIOmero cycTaBHoro penMaTH3Ma, a TannCe
Ty6epiyjle3Horo apTpHTa y Hpynnoro poraToro CHOTa (pile. 112).
CHMIITOMbI H AnarHOCTHHa
HaganbHbie H3MeHeHHH IIpH apTpo3e IIpOTeialOT 6eCCIIMIITOMHO.
TOJIbHO peHTreborpafHLIecni yAaeTCfa onpeAeJIHTb xapanTepnoe cy-
?HeHHe CyCTaBHOii menIII, Han CJIeAcTBHe HCTOHLIeHHl xpnma
(B. C. 3axapoB). C nocJIeAyJoli M pacnaAoM ero H oroJIeHHeM HOCTHOii
THaHH B r eHTpaJIbHmx yqaCTHax 31[[H(J)MOB HaglxalOTCII (yHHI{HO-
HaJIbHble HapymeiHH. Hpi nopa?HeHHH CyCTaBOB HOHe'HOCTeH OHH
BMpalialOTC5I XpOMOTOH c upeBaJiHpoBaHf4eM pacCTpOI3OTBa c yHHgHH
oBHpaHIIfl. CO cToponbl Ta3oBOi3 HOHeLIHOCTH, B cJIyLIae nopan eHHfi
HOJIeHHOrO, a TaH?He HH?HHHx 0TAeJIOB Tap3aJIbHoro CyCTaBa, xapaH-
TepeH Tax na3blBaeMbIH IIeTymHI XOA (((mnaTOBan xpOMOTa)), Hai
ee onpeAeJIFIJIH aBTOpbI IIpomJioro, CLIHTa1 cneljH(HWCHHM CHMIITO-
MoM mnaTa XpOlnpJecHoe 6e33HccyAaTHBHOe BocnaiienHe HHHSHero
oTAeJIa Tap3aJlbxoro cycTaBa). Oco6eHHOCTbIO 9TOIi X OMOThI lIBJiiieTCJI
TO, LITO oba xopomO 3aMeTHa B HaTiaJie pa6oTbi, yMeHbmaeTCH yxce
Llepe3 norlilaca pHTMHLIHoro Mara H Hc4e3aeT B AaJlbnelimeM. Taxoe
-iepeAoBaHHe HOBTOpfieTCH nocjIe Ha?HAOIi AJIHTeJIbnOI3 OCTaHOBxH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
PHc. 113. CyxceHHe cycTaBHblx menen H o6-
mHpxue ogari pape uKaiHH HpH oeTeo-apTpHTe
cxaxaTenbHUro cycTaBa nomaRH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
C TegeHHeM BpeMeHH CTeIIeHt XpOMOTM IIpH OCTeoapTpHTe yCH-
JIHBaeTCf. }RHBOTHOO 6on6me onRpaeTCH BaI(enHOH gaCTLIO KOIIEITa,
B IIOKOe Aep EnT 60JILHyIO KOHegHOCTb uoJlycorHyTOH, a IIpH nopa-
?KeHMH.oAHOHMeHHbix CYCTBBOB 060HX KOHegHoCTeg gaCTO uepeCTy-
naeT C OAHOH Ha Apyryio. HorAa H{HBOTHOe OCBO6oH(AaIOT OT pa60Tb1
Ha IIpOAOJUKHTeJIWHOO BpeMH, XpOMOTa yMeHbmaeTCR, a B HeROTOpEIX
c iygaax HcgeaaeT IIOJIHOCTbIO, 1 TO CBHAeTeJIJ CTByeT o IIpenpanReHHH
BOCHaJIHTBJmnoro IIpogecca.
AJIHTenIbHO8 TegeHHe aa6o IeBaHHR conp0B0?KAaeTCH McAneHHOIi
aTpodHeg MycRyJIOB. Ha TpeTbeM Mec$ iSe OT Hagana IIpogecca CHMII-
TOMII ee y?Ke xopomo 3aMeTHM. K BTOMy me BpeMeHH Ha peHTreHo-
rpaMMax pa3Jnn ialOT ogarH OTJIO?KeHHR coneg B CBH3Kax, Hgo7r~Aa
TaKHfe B Kancyne CyCTaBa, 06bigHO C McAHaJmHOH ero CTOpOHM. JIO-
KaJIH3ai;HH Hx HMeHHO 3Aecb - 3aKOHOMepHOe RBneHHe, nocRojiLRy
TR?neCTb Tena 6onbme AaBHT Ha McJHanbHbie OTAenbi CycTaBOB, rAe
gau e. cJiygalOTCH TaR?Ke noBpe?KAeHHH, o6ycnoBneHHbie gpeaMepnon
Harpyanog. B TR?Kenbix Cnygaxx ocTeoapTpHTa HecKOnbKo paHbme
yCTaHaBJIHBaIOT peHTreHorpa4HgecKH H3MeHeHHH CTpyKTypbi nOCTei,
Bbi3BaHHbie paper HI;HpyloIl(HM OCTHTOM: ogaroBbie IIpOCBeTJIBHHH
onpyrnoa, OBaJIbHOH, TpeyroJmHOH H ApyrHx 4 opM, 000TBOTCTByIO-
n;He cionycaM nanyxapnog peaop6i;HH (pnc. 113). UlHponoe pacIIpo-
cTpaHeHHe IIpolxecca, Kan BTO OTMegan B. C. 3axapoB B oTHoIIIeHHH
TapaanbHoro CycTaBa, BNNHBaHeTCH Ha peHTreaorpaMMax HO HanHgnio
HepaBHOMepxo nonTypHpoBaHHOH, pacmHpeHHOl cydTaBHOH igern
C HepOBHNIMH IIosepxaocTHMH. Hocne1ylofUHe HBneHHH ocTeocnne-
poaa peHTrenorpa41HgecnH xapa1KTepH3yIOTCSi ycnneHHeM KOHTypOB
CYCTaBHNX npaeB nOCTeH, a TaRme HHTeHCHBHOCTbIO HX TeHen, He-
OAHHaROBOH B pa3nHgHbiX ygaCTKax. '
ApTpOa H OCTeOapTpHT He COIIpoBO?nAaIOTCH 6one3HeHHOCTmIO, KOTO-
pyIO MO?KHO 6MJIO 6M BMI3BaTb Ha)aBIHBaHHeM B 06nacTH CyCTaBa
HaH nocpegCTBOM IIaccHBHBIx crH6aHHI3 H paarH6aHHg ero. OAHano
IIOBbimeHHaH gyBCTBHTenbHOCTh aAecb Bce me CynnecTByeT, o6 aTOM
CBHAeTenbCTByeT Hcge3HOBeHHe XpOMOTbi IIOCne BHyTpHapTepHanb-
HbiX BBeAeHHA pacTBopa HOBOnaHHa HJIH IIpOBOAHHKOBOH aaecTeaHH.
3TH cnoco&i MOryT 6IITb HCIIOnb30BaHbi c AHarHOCTHgecnon I;e imio
B KageCTBe BCIIOMOraTenbHbix npneMOB.
L e(opMHpyiomRii aPTPHT IIposIBnneTCn 6onee npno BMpaxseH-
HmIMH ~yHKIjHOHanbHLIMH HapymeHHHMH, ZTO o6ycnoBaeao 6one3-
HeHHOCTbIO BocnaneHHOH HaAnocTHHI LI. HpH HOM XpOMOTa ycHnH-
BaeTCR IIpH ABH?KeHHRx no npyry C KPYThIMH IIOBOpOTaMH Ha nopa?neH-
HyIO KOHegHOCTb, a TaR He BO BpeMR TR?KenOH pa6oTbi. IIpH ycTaHOB-
neHHH AHarHO3a Ba}RHO ygHTIaBaTI, BTopngnMe HBneHHR, HapaCTaioiune
B CBR3H C p$3BHTHOM xpOHHgecnoro o0CHI IHiwpyiou ero IIepHapTpHTa
(IIJIOTHoe BOBBbimeHHe, TyrOIIOABHHCHOCTb CyCTaBa, 6one3HeHHOCTb B
MOMeHTflopCHpOBaHHOro HaAaBngBaHHR H crH6aHHR).
B aanynneHHhlx Cnyganx 3HagHTen16HOH AaBHOCTH H3MeHeHHR KOH-
TypOB CycTaBa Xopomo BW IJbI Hpn OCMOTpe (pHC. 114). OHH Rpxo BbIpH-
COBbIBaIOTCH Ha (2OHe aTpOI HpOBaHHbix MbImg. BonbHoe HiHBOTHOe
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
PHc. 114.
Xponi e-
cxHli I(eiop-
n36eraeT IOMHTbcn, npHciioca6JInBaeTCH o61IermaTL HO-
pallfeHHyIO HOHeLIHOCTb, onnpaflcb Ha CTeHHy cTOI3JIa
mJIII HOpMyunq; JIolHaCb IIpn 3HagHTeJIbHOn yCTaJIOCTII,
OHO Z[WPSH1T HOry IIOJIyCOrHyTOi II 1OTOMy BbIHySH-
Jxeno npnnlMaTb 6ouoBoe noJlolHenne. IIopaHfenne me-
JIIOCTHOTO cycTaBa BeAeT H 6bICTpo nporpeccnpylon1eMy
1CXygaHIIio BcJIeAcTBiie 3aTpyJ(HeHHOFO HieBaHIIg. To
ne B 6owiee 11o3wieM nepHoae Ha6JllogaeTCJI npm ue-
1opMnpyIOweM npoHecce B JIonaTHo-nJieLieBOM, JIOH-
TeBOM, Ta3o-6ej(pennoM, HOJIeHHOM, roJIeHO-cTOnnoM Ii
JIyLie-3anflcTHOM CycTasax y JIOIIIageli II HpyIIHoro pora-
Toro cHOTa. B ATOM CJiyLIae ncxyganne o6ycJIOBJIeHo
HapacTaIoweli yCTaJIOCTbIO M14BOTHOro n noTepeI3 an-
neTiTa 113-3a BbInyHCJAennoro cTOHHHJI. 11OCJIegHee oco-
6eHHO TlflReJlo CHa3bIBaeTCn npn Re()opMnpyloweM
C1OHRiJIHTe Y Hpy1HhIX RoMaHIHHX ?HIIBOTHblx (pnc.115),
IIOHa He HaCTyn1T cpaczafine Tell II03BOHHOB (pnc. 116).
Aim gHarnocTnnn nopaHfeHn1 neHOTOpoe 3HaLienne
HMeeT apTponyHHHwH. B CyCTaBHOi3 HOJIOCTI CHOIJIfTeTCH
6oJibnie, LIeM B HOpMe, ryCTOIi, TFIryLIeii CHHOBIH fiHTap-
HOrO OTTOHRa. OJ;HOBpeMeHHO CO CHJIOPO3OM (1I36pO3HOPO
MHpyrolIAHH JIHCTHa C CTaBHOH HaHC JIhI B II OHOCC BOBJIeHaeTCJI H CII-
apTPHT C IIO- y y p
paxreHHeM HOBIIaJlbnaH o6OJiotIHa. Pa3BHBaeTCfi (1,16po3 BOpcIIHOH.
BepXHerO OT- OHII yAJIHHHIOTCfl, CTaHOBIITCfi IIJIOTHbIMII, IIOCTOHHHO
Jena c aBa- TTTA 1HfTT7TTTTT.TMLT MP.('TAMT (1TTl)nrATnTG.A TTnPTInaiITAAe..T. R
cycTaBa.
Hble Tena CyCTaBOB (a p T P 0 JI II T bI).
Oco6eHHOCTn BHyTpIICyCTaBHbIX II IIOpnapTIIHyJI1PHbIX H3MeHeHIIIi
npn jet opMHpyIOHweM aPTPIITe (COLIeTaHIIe HBJIeHIIII OCTeoapTpiTa H
XpOHJLiecxoro occmi nu YIpyiowero nepnapTpmTa) yCTanaBJnuiBaloTCi
Ha OCHOBaHIII IaHHbIX pelTrenorpaMM.
Jke4opMlipyIOIIhHH CnoH- XpOHAgecnoM ac IiTHgecxoM CHOHJ[HJIHTe.
J[IIJIIT.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
RaToreneTHTIecRaH CBH3b, cyIQeCTByIOfl afI B rpynIIe CyCTaBHMX
6e3aRccyAaTHBHMMX IIpoi eCCOB, onpeABnieT CO6oi o6iwe OCHOBbi
TepauIH, a Tai me BII60p Tex Han HHLIX cIIOCO6oB, Han6onee yAo6o-
npHMeHHMbIx B COOTBOTCTByIOMeI3 o6naCTH Tena.
WHBOTHOe oCBO6OHfAaIOT or pa6oTbi Ha cpoIQ He McHee HonyTopa
MecHgeB H OCTBBJHIOT B IIpOCTOpHOM CTOHJI'e C AOCTaTOTiHMM HOnH-
TIeCTBOM IIOACTHTKH, rAe 6u OHO MOPJIO CB06ogHO IIepegBHraTbCH.
O6HI3aTen16Hbi peryJIHpHBIe, HeCKOnbRO pa3 B CYTHH 19POBOARH HO
20-30 MHHyT, ytIHTNIBaH, TITO IIOJIHMIH IIOKOH 611arOIIPHHTCTByeT
apTpo(lnHecHHM H gerexepaTHBHNIM H3MeHOHHHM B cyCTaBax. Hoc ie
3HaTIHTenbHoro OCna6neHHH Him HC'Ie3HOBeHHfi XpOMOThI IIpOBOJ;HH
yJXJIHHHIOT, H36eraH, OAHaHo, (OpcgpoBaHHMx ABH}KeHHII. B Aanb-
HegmeM HocTeIIeHHO yBeiiHgnBaIOT HarpyaRy B pa6OTe.
B HOpMOBOM paIx!OHe AOI}KHO 6MTb AOCTaTOTIHoe KOJIHTIeCTBO
nerHo IIepeBapHMblx IIHTaTenbHbix BemeCTB (OTpy6H, IInioii;eHoe
aepHO) H BHTaMHHOB. H KOHIreHTpaTaM 9o6aBJIHIOT commie HopMa
(HOpxeimoJ{bI, cHJIOC); B COCTBB rpy6Mx KopMOB BBOAHT nIOI;epHy.
BHYTpb (c KOpMOM) Ha3HatIaiOT cones KanbI;HH. B COCTOHHHH apTpo-
3a, OCTeoapTpHTa H Ae iopMHpyIOIt ero apTpiiTa 6e3 HBHbiX IIpH3Ha-
KOB aHKHnO3Hp0BaHHH paJHOHanbHbl rny6HHHble IIporpeBaHHH (IIa-
pa iHHOTepaIIHH, AHaTepMHH, rpHaenetieHHe, naina MHHHHa).
HoRa HeT JjOCTOBepHMX AaEHMX o HeH36eIEHOCTH aHKii oaa, Cne-
-AyeT BoaRep)BnBaTbcH OT KpOB&BMX OIIepaTHBHMx BMemaTenIcTB
(IIepHOCTeOTOMHH B o6aaCTH HHTepMeTaTap3anmHoro COTIneHeHHH),
IIpoHHKaIou Hx HpH}HHraHgll, a Taio a HMMO6HnHaHpy!OIqHX IIOBH30K.
BTH CIIOCO6LI yMecTHbi, KorJ(a peHTreHorpa(HTIecnH AOCTOBePHO ycTa-
HaBnHBaIOTCH o6mHpHbie IIopaH{eHHH cycTaBHblx HpaeB HocTel H rpy6ble
H3MeHeHIIH co CTOpOHM CycTaBHOH n eam Ha BCeM ee IIpOTH?KOHHH.
IIpH nopaxfeHHHX nonaTHo-nIle*feBoro, IORTeBorO H KoneHHoro
CyCTaBOB xapyprH IIpomIlNX cToneTHH He6eaycnemHo Honb3oBa-
nHCb TaR Ha3MBaeMblMH 3aBoaoRarH. B HaCTOnntee BpeMH TOT CIIO-
co6 B IIpaRTHKe COBeTCKOH BeTepHHapHH OCTaBneH, KaR H McTOA
CHnbHoro pa3Rpa}KeHHH HBeAeHHeM cyneMbl B Ta6neTKax B IIOAKO}K-
HbIH KapMaH, co3AaBaeMMH OIIepaTHBHMM IIyTOM B 06naCTH IIOpaH eH-
noro CyCTaBa. IIx 3aMeHHnH HH1 eHrgHeil pa3ApaxfaIouwx BOIIJeCTB,
KaK, HanpiMep, o'niri[eHHoro cKHIIHJ;apa H cMeCH ero c a( IHpoM.
CKHIIHAap BIIpLICKHBaIOT HOA KOH B KoIHTieCTBe 3-5 Mn (An i
nomaAH). ),nH npeAoTBpan eHHH acenTHTiecxoro a6cx ejxHpoBaHHH
3Ty A03y HH'bHIXHpyIOT ManbIMH IIOpIIHHMH B Tpex-TleTblpex MecTax.
(CneAyeT OTMeTHTb, TITO 3a)KHBneHHe HOCne pa3pe3oB TaiHx a6ci ec-
COB IIpoTeHaeT OTIeHb ycnelIIHO). Bonee 944eRTHBHO BHyTpHMblmeTf-
Hoe BBeAeHHe B OKpyH(HOCTH uopa}KeHHoro CyCTaBa CMeCH cRHIIHgapa
H 9f )Hpa, B3HTMX B paBHBIx COOTHOIIIeHHHX. Oj HOKpaTHaf Ao3a ee
AnH nomaAH COCTaBJIHeT 8-12 Mn (no 3-4 Mn B HeCKOnbRHx McCTax).
TaRHe HH'beRgmH, KaT aTO IIOATBep}ifAaeTCH MHorogHCneHHIIMH KnH-
HHTIecKHMH Ha6JIIOAeHHHMH, He conpoBoH aIOTcn a6cgeAHpOBaHHeM.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B o6aaCTH pa3ApameHHfl B03HHnaeT o6mHpxaR IIp1ffnYX IOCTb, ROTO-
pafl Hcge3aeT TOII16H0 H 8-10-My AHIO HOCJIe HpHMeHeHHfi HpenapaTa.
Ha 9TOT IIepHOA HlHBOTHOO OCTaBJIHIOT B CTOfJIe. HOBTOpHyIO nH'beH-
AHIO 11pOH3BOAHT gepe3 ABe HejenH. K 3TOMy BpeMeHH xpOMOTa
o6binHO 3HagHTen16HO ocrla6eBaeT, qTO CJIy fcHT XOpOBIIIM HporHo-
CTHgeCnHM Hpl3HaHOM.
TaHoH c10006 TepaHHH geJlecoo6pa3eH B cnygaflx Hopan eHHH
CyCTaBOB Hp0HCHMaJIbHoro HOJIOHIeHHH - JIonaTHO-IIJIegeBOrO, Ta30-
6eApeHHoro H xoJIeHH0rO, rAe no COCeACTBy aeHlaT MaCCHBHble IIJIaCTbI
MLIHII;. MexaHH3M AOlCTBHH HpH 3TOM CHOCO6e TepaHHH 3aI(JIIO*IaeTCH
He TOJI16RO B pa3ApaHleHHH H aHTHBH3HpOBaHHH BOCIIaJIHTeJIbHOH
peanluHH. IIpOAyHTbl pa3ApaHleHHfl THaHeJI JIBJIgIOTCJI BenJeCTBaMH
HedneIJH(HgecRofi 6eJIHOBOI3 TepaHHH, cT1AMyJIHpyIOweI3 06MeHHble
Hpolieccbi B opraHH3Me H perenepainlo.
TyrouoABHMHOCTb wJIIOCTHOro cyCTaBa Ha HOgBe ge(opMHpyIO-
H;ero apTpHTa Tpe6yeT pe3eHI;HH c pacqeTOM nonygenHfl JIoHfnoro
cyCTaBa. Cyub6a HIHBOTH0ro IIpH HCTHHHOM aHnHJI03e ApyrHX CycTa-
BOB TaHaH ne, Han H B CJIyiIagx JIOHfHOr0 anHHJlo3a, B03HHHaIOmero
nail HCXOA xpOHHLIecnoro occH(HI[Hpyiomero HepHapTpHTa.
PEBMATIILIECKOE BOCIIAJIEHRE CYCTABOB. CYCTABHO$ PEBMATII3M
(ARTHRITIS REUMATICA)
3THOJIOrHLIecHHe ( aRTOpbl CycTaBHoro H MLIIIIe'HOFO peBMaT113Ma
OAHII H Te ne. 3a6oJIesanne HaHLIan a Ha6nioAaeTCU Y MOJIOAMIX CBH-
HeH HpH co epnIaHHH HX B CiIpMIX, XOJIOAHbIX noMeujeHHflx, 3aTeM
y co6an H y nomaAei3. B ero Te'IeHHH pa3JIHLIalOT ABe CTaAHH -
0CTpy1O H xpoHHgeCHyio.
IIaTOJIoroaHaTOMHgecjHe H3MeHeHHJI
B 0 C T p o fl C T a a H H cyCTaBHoro peBMaTH3Ma H3MexeHHH B OCHOB-
HOM pa3BHBaIOTCH B CHHOBHannbxoj3 o6OHOgne. OHH xapanTepH3yIOTCsl
rHHepeMHeI3, Ha6yxaHHeM BopCHHOH, HH~HJImTpagHeI3 HOACHHOBHanb-
Horo cJIOl H pUIXJIbMX IIapaapTHnynflpHblx THaHeI3, T. e. HapTHHOf
OcTporo CHHOBHTa. B cycTaBHOII IIOJIOCTH yule B TegeHHe HepBbJX
CYTOH 3a6oneBaHHf1 CHOIInHeTCfI cepo-~H6p1Ho3HhIK anccyAaT. IIpH
CBoeBpeMeHHOM ne'OHHH OTMeLIeHHble H3MeHeHHfi HCge3a1OT B CpaBHH-
TeabHO HopoTnHI3 cpOn (8-10 AHeg). OAHano Hepe6oaeBHlee HcHBOT-
Hoe CTaHOBHTCn OLIOHb gyBCTBHTenbHMMM H COOTBeTCTByIoHxeMy aHTH-
reHy, a TanHle n oxJIa?n eHHIO, B CBJI3H C qeM y Hero gaCTo 61IBaIOT
HOBTOpHbIO BCHIIHIHH Hpogecca.
C HepexoAoM 6one3HH B x p o H H g e c n y Io chi o p M y ocnoBy IIaTO-
noroaHaTOMHgecnHx H3MexeHHII COCTaB1HIOT nponl(epaTHBHLIe HBne-
HHfi: cnnepo3 CyCTaBHOH nancynbl, ROCTHMe pa3paCTaHHn B ( OpMe
OCTeO(HTOB B OnpyHfHOCTH cyCTaBa, (H6po3 B CMeHIHhIX HnacTax HneT-
gaTnH. TaRHM o6pa3oM, xpoHHgecnHH CyCTaBHOH peBMaTH3M xapan-
TepH3yeTCH HpH3HanaiH Aec opMHpylon;ero apTpHTa C TOH oco6eH-
HOCTbIO, iITO AeCTpynTHBHbie IlpogeccN B 1OCTHOH THaHH H B xpfli e
pa3BHBaIOTCJI 3Ha1HTenmHO McAneHHee, geM B ApyrHX caygafix.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
I{JIHSH9eciHe ORMIITOMbi u AnaraocTHKa
PeBMaTHgeCKOO BocuajieHHe cycTaBOB B OCTpOi CTaAHH COIIpO-
Bo)xAaeTCH IIpHnyxaHHeM TKaHeH B o6nacTH nopa)KeHHbIX CYCTaBOB
B CBHBH C BOCII8JIHTeJI6HbiM OTeKOM. HaIIOJIHeHHe IIOJIOCTeI He AOCTH-
raeT BLICOHOE CTeneHH, H (~AIORTyaI wn BBIpaH{eHa cJIa6o. llpH Ha-
AaBJIHBaHHH Ha Onpy)EHOCTb cycTaBa H IIaCCHBHMMX ABH)HeHHHX OT-
McHaeTCH CHJIbHaa 60JIeaHeHHOCT16. XpOMOTa HaCTyIIaeT BHeaauHO.
06IIgHO OAHOBpeMeHHo HapyIIIaeTcH 41yHKIXgH HecxolibxHX KOHe4-
HocTeH - AByX ENE Beex qeTbipeX. B Taxgx cnyqagx )HHBOTHOe Ho-
Aonry ne)KHT, a B CTOHHeM IIOJIO)HeHHH iia0TO IIepeCTyIIaeT C OAHOH
HOPS Ha Jlpyryio.
06pan aeT Ha ce6H BHHMaHHe neTy`ieCTb aa6oneBaHHH, T. C.
nepexoA ero Ha pyre CyCTaBbl TOE me xOHeiIHOCTH ERE IIpOTHBO-
IIOJIO)KHOE CTOpOBbI. Tan, B TezleHHe AByx-TpeX HeAenb .nocneAOBa-
TOHbHO BOBHHKaIOT CHMIITOMII nopa)xeHHH MHOFHX CYCTaBOB C HOBTOp-
HbIMH BcnbIIIIxaMH IIpoi;ecca B HBKOTOPIIX H3 HEX. IIpH ATOM Bocna-
JIHTenbHble HBneHHH B xax(AOM CyCTaBe coxpaxaIOTCAHecxOnbxo AHeH.
TeMIIepaTypa Tena B nepBble ARE aa6oneBaHHH alagHTenbHO HOBbI-
inaeTCH, IIHorAa Ha 2? H 6oni:me. B nocneJjyloJI eM yCTaHaBJIHBaeTCH nH-
xopaJ(xa HeIIOCTOHHHOro THIIa, C 6onLMHMN xone6aHHHMH TeMnepaTypbi
Terra - OT HopManbHOH Ao rpaHHij IIepBoHa*ianbnoro IIOBbifeHHH ee.
B xpOHH4eCKOE CTaAHH BCe HBneHHII OCTpOro cHHOBHTa H aHXo-
paAKa ocna6eBaIOT Hnn xie IIOJIHOCTbIO HClIe3aIOT. BMeCTO HHX HO-
CTeIIBHHO IIOHB1HIOTCH CHMIITOMUI Aecf opMHpyiomfero apTpHTa. Xpo-
MOTa CTaHOBHTCH peI;HAHBHpyIor eg. IIpH ABHHeHHH HpocnyIIIHBaIOTCH
IIIYMMI TpecKa H TpeHRH CyCTaBHLIX IIOBepXHOCTeH.
B AH#epeHILHanbHO AHarHOCTHiiecioM OTHOIIIeHHH Ba)KHOH OT-
JIW1HTenbHOH Qco6eHHOCT16I0 CyCTaBHOTO peBMaTRBMa HBnHeTCH HO-
paHfeHHe HeCxOnbxgx CYCTaBOB (II O Jt H a P T P H T), rnaBHbIM 06-
pa3oM 6onee. MaCCHBHbIX (KoneHHoro, roneHO-CTOIIHOrO, JIonaTKO
IIneeeBOro, nyile-3aUHCTHOPO).
YCIIeX TepanHH Bceneno 3aBHCHT OT cBOeBpeMeHHOCTH cooTBeT-
CTByIOiIaHX Mep0HpHHTHH. Kan H IIpH MbillIeiIHOM peBMaTHaMe, )HH-
BOTHOO HYH{HO coJ[ep)KaTb B TennoM, CyXOM noMeIr eHHH C o6HJIbHOE
IIOACTg1HOE. Hopa xeHHble CyCTaBbI yxyThIBaIOT MHrKHM BOEJIOKOM
H1H KOMIIpeCCHOE BaTOH. ExceAHeBHo BTHpaIOT neTyiiHe 1HHHMeHThI,
B COCTaB KOTOpMMX BXOAHT o6ea6ojuiaaionme cpeACTBa (xnopo4opM,
6eneHHOe Macao) HiH McTHJIOBBIE 9#P CanHI[HJIOBOE xHCJIOTM.
BHyTpb HaaHaLlaIOT canKAKJIOBOxHCJIbIE HaTpHE. OH 6onee a((ex-
THBHO AeECTByeT, 6yAy=IH BBeAeH B paCTBOpe BHyTpHBeHHo, oco6eHHo
c OAHOBpeMeHHbIM HepenHBaHHeM xpOBH ERE TKaHesol TepanHex,
naKTOTepaIlHeM, ayToreMo1epaIIHeg (CM. pa3Aen o MMIIlegHom peB-
MaTH3Me).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
r a _4 zI A %r
HOPAH(EHHH HEPBHbIX CTBOJIOB
OTKpbITbIM II 3aupblTbIM uoBpe?KAeHHHM TKaHeII HepeAHO COIIyT-
CTByOT TpaBMHpOBaHHe HepBHTIX CTBOJIOB. TameCTb ero MOHCeT 6MTb
pa3JIIILIHOH: OT c ia6o BbIpaHSeHHbIX 1I3MexeHHA Co CTOpOHbI IIepH-
H 3HAOHeBpaJlbHLIX Me3IKIIX COCyAOB BIIJIOTb AO IIOJIHOrO IIOHepeLIHOPO
pa3pyIIIeHHH HepBa Ha 60JIbIHOM IIpoTHHSeHIIH. HOBpe7ICJ;eHHSi HOpBHhIX
CTBOJIOB 06yCJIOBJIHBaIOTCH Tai-Re cgaBJIHBaHHeM IIX TBOpgLIMYI
HHOpOAHmIMII TeJIaMH, pa3paCTaHHHMH KOCTHOII TKaHII, MaCCHBHbIMH
py690BMMH HaIIJIaCTOBaHIIHMII, OIIyxOJIHMH II T. A. HOMIIMO IIepe-
LIHCJIeHHbIx MexaHHLIec1Hx BJIHFIHHI3, =FaCTO$ IIpH'IHHOI3 IIopaSKeHHFI
HepBHbIX CTBOJIOB HBJIHIOTCH HH(eICI;HOHHO-TOKCHLIeCKHe BO3AeHCTBHH.
g,HHaMIU a MOp(PoJIorugec[SHX H3MeueHHM
CTpyr TypHbie H3MeHeHHH IIpH IIopaaceHIIHx HepBHbIx CTBOJIOB
MOT HMeTb MOCTO B OCOBbIX I;HJIHHApax MHKOTHbIX I3 6e3MHKOTHbIX
BOJIOKOH, B MH3JIHHOBOH H IIIBaHOBCI{OH o6OJIoTFKax, a TaRMO B 3HAO-
HeBpHH H HeplHeBplH? ,IJIIHaMHKa IIX B AOCTaTOMHOA CTeneHH BbIHC-
HeHa alenepRMeHTaJIbHLIMH HCCJIeAOBaHHHMH, IIOCBHmeHHI MII BO-
HpOCy 0 pereHepagHH IIepepe3aHHbIX HepBHbix CTBOJIOB.
Hepl4)epHLFecHHI3 OTpe3OH IIepepe3axxoro HepBa, He HMeIol(HI3
CBH3H C KJIeTKaMII IIeHTpaJIbHOII HepBHOII CHCTOMbI, cpa3y yTpauH-
BaeT IIOJIHOI[eHHOCTb B ( yHKJjHoHaJIbHOM OTHomeHIIH. OAHaHO B 3TOT
MOMOHT B HeM OTCYTCTByIOT HBJIeHHgI, HOTOpme MO5KHO 6bLJI0 6bi
o6HapyamTb, IIOJFb3yHCb McTOAaMH MOpI o3Iorl'JeCHoro HeciieJ[oBa-
HIIH; AerexepHpyeT OH B IIOCJIegyIOH;eM Ha BCeM IIpOTFI}KeHHH.
H a q a JI o 3 T O F O II p o J e c c a Ha6JIIoj(aeTCH B TeueHHe IIepBbIX
CyTOK nocae HoBpellcJ;eHHH. OH xapanTepH3yeTCU Ha6yxaHIIeM, BaKy-
OJIH3agileH, BapTX03HbIMH yTOJIII;eHIIHMH OCeBNIX I;HJIIIHApOB. HepBHble
OKOHLIaHIIH H KOHIJeBbie. BO IOHHa B JJ;eHepBIIpoBaHHLIx MbIIIIIJaX
K 3TOMy BpeMeHH coxpaHHIOTCH HeH3MeHeHHbIMH; OHII JIIIIIIb McCTaMH
enema Ha6yxaIOT (pnC. 117). HpoBexocHbie COCyALI 3HAOHeBpIIH
pacmIIpellbl. B onpy5FnH0cTH Hx o6Hapy?KHBaioTCH 0TJ[eJlbxbie y'iacTKH
cHOIIJIeHIIH JIOIIKOAHTOB H JIHM[ OIJHTOB. B036yAHMOCTb II IIpOBO-
AHMOCTb Hep4(epwFecnoro OTpe3Ka HepBa elge coxpaHeHa.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
PHc. 117. Ha6yaaaae HepsHUS BonoeoH: BBepay nano HaMeHeHHoe
HepBHOe OROHYaEHe; BHHay - pacuaA ero (no JI. H. QDonfiay).
PHC. 118. PacnaA HepBHLIX BOJIOHOH c o6paaoBaHHeM OBOHAOB (Ho JI. H. (DoJmny).
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
Bo B T o p o ii C T a g H H AereHepagnH oTMegaeTCH (parMeH-
TaI;HH H pacna;X HepBHblx BOJIOKOH C o6paaoBaHHeM TaH na3bIBaerbIx
OBOHAOB, B HepByIO oilepeAb B y,~laCTHe BHyTPHMLIHleYHLIX BeTBJleHHii
H CO CTOPOHhI HOHI;eBblx pa3BeTBJIeHnil B IIpOT01JIa3Me MOTOPHLIX
6JIHHIei (pnc. 118). 3Aecb Y HpoJTHHOB HBHLle npH3HaRH Aerene-
pagHH o6HapyHfHBaIOTCH yHCe LIepe3 24 Tlaca nocdTe OnepaIWH H He-
CxOJIbHO no3me (cnycTST 48 LTacoB) y HOIHex n co6aH (Ji. H. OorinH).
Ha 3-4-I3 genb (J]parMeHTaqnJI OceBLIX IWHJTHHAPOB oTLIeTJTHBO 3a-
McTHa H B RpyrHX OTJ;eJTaX HepBHOro cTBOJTa (pnc. 119).
HeOAHOBpeMeuHOCTb pa3BHTHH Z[erenepaIinn no Z[JTHHe nepn4e-
pHLlecKoro oTpe3na HepBa, 6oJTee pannee nOHBJTeHHe ee npH3HaHOB
Pic. 119. mparMeHTarHH oceBblx AHJmHApoB (no IT. H. (Dorn Hy).
B HpeTepmHHaJTbnbix ytiacTnax OceBBIX I(HJTHHAPOB H B onOHtiaHHHx
O6'bHCHHIOT, B COOTBeTCTBHI c y*leuHeM H. E. BBegeHcnoro, McHbIneI3
( H3HOJIorwJecnon HOABH?HHOCTbIO H MaJIOH pe3HCTeHTHOCTbIO 1110-
CJIeAHHX.
B Hagajie BTOpOH cTai;HH J;erenepal;HH eme He Ha6rno aeTCH
H3MeneHHi3 CO CTOPOHLI M1d3JIHHOnoi o6oJIOtnn. ficno BLlpaxcennble
HapynleHHH BHyTpeHHeH CTpyHTypbl ee 3CTaHaBJI1dBaIOT Ha 3-4-il
J[eHb uociie onepaluHH. Ha 5-ii Aenb o6HapyufHBaIOT XnMntiecnne
H3MeHeHHH MHaJIHHa c npeBpanweHHeM ero B 1HHp.
Heo6xoAHMo OTMeTHTb, LTTO nepepoxtienne HOHI;eBLIX HepsabIX
annapaTOB cOBepnlaeTCH HeOAHOBpeMeHHO Be Bceii HX Macce. Ho
H. 11. HTaBJIOBy, B036yj[HMOCTb pa3JIHLIHblx HepBOB nocdTe pacceTleHHH
Hx Hcile3aeT tepe3 pa3JIHLIHble CpOHH. Cornacno gaHHbIM E. H. 7i#y-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
KOBa x ero COTpyJ(HHKOB, TaR HaaiBaeMHe TOnK IeCHHe MEIB O HMe
BOJIOHH& McHee JIa6HJIbHbi, 'reM MOTOpHHO, HpeAHa3Ha9$HHbie JI,JH
IIp0BeJ[eHHH J{BHraTenbHMY HMIIyJIbCOB. IIOJ#06Hoe gBzeHxe ycTaHoB-
aeHO E. H. IIne9HOBOg B OTHomeHHg HepBOB cep=a: gyBCTBHTeAb-
Hbie HepBHbie BOJIORHa H HX HOHljeBNO o6pa3oBaHHFI B MHOxap o
yCTOg9HBee ABHraTOJIbHbIX i OHH prerenepHpXaoT aaa9HTeJIbao 1103)1{0,
qeM BOJIOICHa MOTOpabIX HepBOB cep=a. OAHOpOAELIe B ~yHxIUHO-
HaJmHOM OTHOIIIOHHH eneMeHTM TaK)Ke norl6aIOT He B OHO H TO me
BpeMH, ZTO, BepOHTHO, 3aBHCHT OT pa3JIHirHoro (ln3IIOnorH9ecxoro
COCTOHHHH H% B MOMOHT IIOBpe}HgeHHH (JI. H. (DoJIHH).
TaI OBN oco6eHHOCTH J;ereHepagHH HepBOB, npOTexaionue 110 B a n-
n e p 0 B C H 0 M Y T H It Y B IIOpH( epH96CKOM OTpeaRe. B I;eHTpanbHOM
oTpeaxe, CBfiab OCOBMX I;HJIHHApOB KOTOporo C HepBHMMH xneTxaMH
OCT&eTCH HenapymeHHOf, H3MeHOHHH oxBaTMBaIOT orpaHIIgOHHMg
yilaCTO}. OTCIOJ;a IIpO1CXOJ;HT pereHepai;HH HepBHOr0
CTBOna. 8TOMy IIpoiieccy IIpegIIIOCTByeT eHeprHgHoe pa3MHomeHHe
xneTOx IIIBaHOBCxoi 060JIO9KH c (IOpMHposaHHeM CIHAHTHH no xoJjy
IIorH6IIIHx OCOBLIS 9HTHHApoB. TJIMH xneTO'IHOro CIIHIfHTHH IIpeg-
CTaBUHIOT C060g nome, 6naronpIHTHOe J;is pocTa IWHJIHHJ;pOB.
TOM BpOMOHOM B peaynbTaTe paapacTaHHH KneTOR IQBaHOBCROg
060JIo RII H OCeBMX AHJIHHJ;pOB Ha IXOHTpanbHOM ROHI1O HepBa o6pa-
ayeTCH B3JjYTHe - txon6a pocTa*. Hor);f 1OHMM HepBa He cMengeHM
B CTOpOHUI H HO AJIHHe H B IIpOMe)1iyTKe MO7R Y HIIMII 3aJleraeT TOHHHH
CJIOI3 HOB006pa30BaHHOg COOJUHHHTenbHOII TxaHH, OCOBMe IwHJHHApbi,
pa3paCTaHCb, IIpOHHKaIOT B IIIB1HOBCRHH CHHIIHTHg H, IIOCTOIIOHHO
yA1HHHHCb, IIpOHH3MBaIOT ero BO BCIO AnHHy norH6IIIero OTpeaHa
HepBa. HOHOgHMM eTanoM Hx pereHepagnH HBJIReTCH o6paeoBaHHe
HO BHMX OKOHgaHHg B TKaHax. ecKOnbxO IIOe ae BOCCTanaBnHBaeTCH
MHHOTHaM 06oUOgxa.
gum peresepairB'H HepBOB co3 aIOTCH He6naronpHHTHwe ycnoBHH
npa paapacxaHHH MaccHBHLIx py61XOB B ygacTxe nQBpex(AeHHH.
TonH(HHa Ha CBHIIIe OAHOro caHTHMeTpa 11peACTaBUHeTCH Henpe-
0J;OnHMOg nperpaAog Ha IIyTH pocTa OCOBMS I;HJIHHJ(pOB. B TaROM
cny9ae Ha 1OHIIe ieHTpanbHoro oTpeaxa HepBa (OpMHpyeTCH ony-
xoneBHJ[HOe pa3paCTaHHe H3 ryCToro CIIJIBTOHHH HepBHNX BOROROH,
HenpaBHnbHO HMeRYOMOO IIeROTOpHMII aBTOpaMH HespoMOg.
HepeAxo 4yHKgHH HepBa yracaeT HaBcerj{a BcAeAcTBHe J;ereae-
pagxH ero IWeHTpaJIBHOro OTpe3xa H COOTBeTCTB1IOH HS rpynn KneTOx
IPHTpanbHOH HepBHOg CIICTeMH. Tanoi THn Hepepoac1;eHHH (H x c-
c n e B C x 0 e) HaCTynaeT uocne rpy6Ha TpaBMaTHgecHnx Bo3J;eH-
CTBHg, COIIpOBo)R aIoII;II%CH' pa3Mo8xceHHeM HepBOB, THBTeu0H HH4leK-
gaeg HJIH rny6oxoI HHTOxcwxaI HeH opraHHeMa. HHorAR B OCHOBe
HaTOreaeaa ero ae)KaT 11porpeCCHpyion ae BOCIIanHTeJibHMO HaMe-
HOHHH, CBOHCTBOHHMe BOC%OAHmeMy HOBpHTy.
IIOBpe 1( eHHe xpYIIHMX HepBHHS CTBOnOB (ceJ;auanHMH HepB)
BJIO 0T as co60g zapa1TepHMe HaMeHOHHa Toro Me HepBa HpOTHBO-
IIOnOH{HOg CTOpOHH (IIOHBneHHe BaKyOAeg B OCBBMX I;HJIHHJ;pax,
paapixneage 11ygx0B Hegpo4ia6pHJIA, o6paaosaaae Bapaxo3HI1X
12? 839
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
yTOnneHgg). e3TH HBaern ii HalOMHHa1OT co6OT3 npoljecc1, Ha6Jl1o-
gaeMLIO B IIoBpeM;XOHHOM HepBe, Ho 6LIBaIOT cJIa6o Bblpa)Rexbi. OHH
o6yc7IonaeHLI pe(JIeHTOpHNNMI HapyIIIenu Tp0[ HLIeCHOH (YHHILHH
HepBHOI cl4cTeMbI.
KJIHHHLIECKHE IIPH3HAKH
CoOTBeTCTBeHHO CTeIIeHH Hopa?HOHHH H MOp mor weRHM H3Me-
HeHIIJTM HepBa B naH{AOM OTgenbHOM CJIy*Tae Ha6JIIOJ[aeTCH TTaCTHLIHaq
HJIH IIoJTHas1, HpaTTfospeMeHHaa HJIH yCTOH HBO coxpanSTToii aaca
IIOTepi B036YA11MOCTH H IIpOBOAHMOCTH HMIIyJIbCOB.
C O T p R C e H H R HepBOB, B03HHHa1Ou He npH CHJIbHJIX, CTpeMH-
TeJIbHbIX MexaHHLTecRox 3303J{euCTBHRX, Hanpl3Mep IIpH paHeHHRx Mac-
PHc. 120. flapanuq ceRairHlgaoro Hepsa.
CHBHMMH ocHoHIHaMH CHapn1.[oB, He HpOHBJIRIOTCR Bblpa}HeHHTIMII
CTpyKTypHLIMH H3MOHCHHRMH HepBHbIX CTBOJIOB, IIpOXOgRU IX Ha
HeHOTOpOM OTgaJIOHHH OT paHeBorO 14aHaJla. B HHX MOryT 6iITb o6Ha-
pyH{enbl ToLIei1HMe RpOB0H3JT12[RHHR. B HocJIegyIOH[He IIepBble LIacbl
pa3BHBaeTCR orpaHH1TOHHLIII OTeR.
B (yHHgHOHaabHoM OTHOIIICHHH TaHoe CocTORHHe xapaKTepH-
3yOTCR BpeMeHHLIM HapaJIHLIoM. PaHbIIIe BocCTanaBJlHBaeTCR coHpa-
THTeJIbHaR CII0006HOCT16 COOTBeTCTByIOIIUHX rpyIIII MycHyfloB, 3aTeM
60JIeBas 'IyBCTBl3TeJIbHOCTb.
V III H 6 a m HepBOB 061JLTHO COIIyTCTByIOT 3HagHTeJIbHble aHaTOMH-
*TecHHe H3MeHeHHR: HpOBOH3JIHRHHR, pa3pymeHHe MHDJIHHOBOg 060-
JIOTTHH H OTAeJIbHMIX HepBHMIX BOJIOHOH; B J;auIbHenmeM HepBHLI13
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CTBOTI IIPOIIHTb1BaeTCH HH( HnbTpaTOM; IIOBpe1*C OHHble oceBbie I;H-
JIHHApbI J{ereHepwpyIOT; Hepep(Ko B yiiacTKe IIospex AeHHfi paspa-
CTaeTCH yJ;JIHHeIIHbIn y3eJI py61XOBOg TKaHH.
tDyarn uoHaJImHbie HapymeHHH B BTOM cnyeae ycTOg*IHBM. tlan e
oTMe'IaeTCH napes OTJjenLnMx MyCKyJIOB, HHHepBHpyeMblx IIoBpexcJjeH-
HMM HepBoM, peace IIapanH*i (pHc.120). K KOHIjy BTOPOA Hejjennnocne
yniH6a MoHCao 3aMeTHTb HB-
neHHH aTPOkHH MyciynOB.
B IIepBble pHH Ha) aBJIHBa-
HHe Ha HepBHldg CTBOJI HpH-
19HHHeT CHJIbHy10 6oJIb. Ta-
KHe me CHMIITOMLI HPHCyU;H
pacTH?KeHHIO HepBOB.
P as ii B LI HepsoB BJIe-
KyT as co6oiuoUHr uapanH*i
JjBHraTeJII HMx H ZIyBCTBH-
TOJlbablx BOAOKOH (pac.121).
Mycxynbl B STOM cnIy*iae
upeTepueBaIOT iirpoBoe ne-
peposKJjeHHe. I'Ix BonoiHa
yTpailHBaloT Honepe'IHyIO HC-
,Iep*ieHHOCTb, CTaIIOBHTGH
3epHHCThIMH H3H roMoreH-
HIJMH. O) HOBpeMeano C Jje-
reaeparuHeii H IIporpeccuB-
HMM HGTOHTeHHeM MMUIeq-
HLIX IIy'KOB paapacTaeTCH
BHyTpeHHHf IIepHMH3HH. PHc. 121. AByCTOpOHHHi IIapa;iHH HOHeY-
TKaHH AeHHHepBHposaH- HoCTefi c cozpaaeHHeu HHHepBaI;HH opraaoB
HOB o6naCTH Tena OTeqHbi. TaaOBOH IIOJIOCTH H xBOCTa.
OHH O*ieHb TiyBCTBHTenbHbi
H BceBOaMO3KHeHIHHM BHeIIIHHM BOBJjeICTBHHM H B eny*iae pa3BH-
THH HH(ercAHH pa3pymaloTCH Ha 3HaTIHTenbHOM IIpOTHn eHHH. 110-
KPOBbI Tena *iacTO H3'bR3Bn5IOTCH. HpKHM BblpaxceHHeM rny6OKHx
Tpo(1HqecHHx paCCTpOHCTB IIPH HOBpe}KJ(eEHH HepBablx CTBOJIOB
KoaeTIHOCTei y nomaJgeii HBJMeTCH cnaJjenHe HOI TITHOro pora.
C Jj a B n H B a 11 H e HepBOB, KorJja 0110 J;OCTHraeT BMCOKOH CTeneHH
H cyIIJeCTByeT JjnHTenbHOe BpeMH, B0 OT H JjereHepai;HH oceBblx
1;HnHHApOB H pacnaJjy MHBJIHHa. HcxOJj B BTOM Cnyqae TOT ace, TITO
Hpi paapbuBe HepBa: Hapanii pe3HO Bblpa?HeH, pereaeparwsi HepBa
LIpe3BbI,qaHHO 3aTpygHeHa.
HespHT (neuritis). ConpoBO?R1(aeT TpaBMaTHLIeCKHe IIOBpein eHna
H Heas6eHfuO BoaagxaeT IIPH rnogublx Hpor[eccax B oxpyH{HOCTH
HepBHMIX CTBOJIOB, nepegHo pa3BHBaeTCH HpH MMITe, cny=inog 6onesnu,
nn nyaHi e (y aoma)[eg), 6pyi enneae H JjpyrHx HH41eHAHOHHMIx aa6o-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246A043800010001-4
JIeBaHgxx, IIpH peBMaTHTIeCRHX 3a6o7IeBaHufix H'IyMe (y cO6ax), B-aBH-
TaMHHo3e (y IITHIJ), a ace Bc1IeACTBHe HoegaHHJI TOHCH'TeCHHX BeIITeCTB
(nopaHfeHHe BO3BpaTHOro HepBa y JIOIIIaAeIi IIpH HOpMJIeHHH *THHOi3).
TpaBMaTHLIecI{He HeBpIITbl B 6OJIbmOM gHCJIe cJIyiIaeB 3axaH-
rHBaIOTCH IIOJIHbIM BOCCTaHOBJIeHHeM 4)yHHJI IH IIopameHHoro HepB-
Horo CTBOna. B 3TOH rpyIIIIe oHaaNIBaIOTCR oco6eHHO TgmeJImIMH
BodnaJIHTeiIbHble npoiiecem, o6ycJIOBJIeHHble CAaBJIHBaHHeM HepBOB
HJIH HepBHNNX KOpefKOB HOCTHBIMH pa3paCTaHHHMH, IIJIOTHBIMH
onyXOJIHMH, HHOpOAHMMH TeaaMH, JxoHaJIH3yIoumMHCa B O6JIaCTHX
TeJIa, HeAOCTy1HNIX gan onepaTHBHOrO BMeIIIaTeJIbCTBa. CpeAH TaRHX
( OPM IIpOTeHaIOT HCKJIIO'IHTeJIbHO Trn eJIO HeBpHThI H paAHKYJIHTNI,
BNI3BaHHNe OCCH(JIHI 11py1OmHM IIepHOCTHTOM B O6JIaCTH H03BOHOgHHKa.
BocuaaeHHe HepBa HH(eRIuIoHHoro IIpoHCxom{AeHHH HepegHo IIpo-
rpeccnpyeT, pacIIpOCTpaHaaCb B AOHTpocTpeMHTeJIbHOM HaIIpaBJIeHHH
(B o C X 0 A a II; H I3 H e .B P H T). HpH 3TOM AerexepaTHBHIIe H3MeHeHHsI co-
OTBeTCTByIOiAHX HepBOB IIpOTHBOIIOJIOMHOH CTOp0HBI 6OJIee IIOCTO$IHHMI
H gait a Ha6JIIOAaIOTC}T, geM B CJlygaJIX TpaBMaTHgeCKHx HeBpHTOB.
B OCTpOH CTaAHH BOCIIalIeHHJ HepBOB BeCbMa 3HagHTeJImHa 6oJIe3-
HeHHOCTb. BoJILHoe }KHBOTHOe H36eraeT ABHHCeHHH; IIpH IIOHLITKO
IIaJIbHHpOBaTb OHO BceMepHO yHJIOHfIeTCJI, HHOr) a CTOHeT. BpocaeTCn
B rna3a OAHOBpeMCHHOe o6HapyxceHHe B O6JIaCTH pa3BeTBJIeHHf
nopaHCeHHoro HepBa 3OH rHIIepeCTe3HH H IIOHH)KeHHOH gyBCTBH-
TeJIbHOCTH HO}KH. iIacTO Ha6JIIoAaeTCa 3yA. MycHyiImI Hanpa}KeHN,
a IIpH AOTpamBaHHH H IIOKpOBaM 6oTIe3HeHHNIX ygaCTKOB OHH CyAO-
poHCHo coHpaIRaIOTCfI. TaKHe HBJIeHiq cMeHHIOTCH IIpH3HaHaMH
yracaHHa IIpOBOAHMOCTH HepBa BcJIeACTBHe ero AereHepaiJHH.
Jlegeime
Ho1Hble nouepegHble pa3'LeAHHeHHsi HepBOB Tpe6yIOT HalIOHfeHHH
IIIBOB C IReJIbIO C6JTH3HTb HOHIIhI Hx go HenocpeAcTBeHHoro cOnpH-
KocaoBeHHH. IIpH 3TOM paHa o6pa6aTmIBaeTC$I C BO3MOH{HOI3 Tma-
TeJlbHOCZbIO AJIJI C03AaHHS yCJIOBHI3, o6edIIegHBa-iomHX 3a}KHBJIOHHe
IIO IIepBHgHOM3 HaTr TceHHIO. HepBHNi CTBOJI yRyTbIBaIOT CMeMHO
JIeIKaIUHMH 4)aCI;HaJIJ,HIIMH JIHCTKaMH H }KHpOBOH KJIeTnaTKOH. 11OKOH
B IIocaeonepagKoHHoM IIepHOAe co3AaeTCa HaJIolReHHeM HMM06HJIH-
3Hpyxoleg IIOBa3KH B IIOJIOIKeHHH IIOBpe?11 eHHOrO gnieHa, IIpH KOTOPOM
Mann 6LmH 6m paccJla6JIeHMI (Ha HOHegHOCTHX - B IIonycorHyTOM).
B BeTepHHapHOH IIpaRTHKO K TaIHM OIIepaI;H1M, a TaKxce BbxCBO6o-
HfAeHHIO HepBOB H3 py6I oB, IIJIaCTHgecHOMy 3aMemeHHIo Ae()e1TOB
IIO AJIHHe CTBOJIa IIpH6eraiOT pe)KO.
IIpH 3a1pMITLIX MexaInT ecKgx IIOBpemgeHHHTX HepBOB HcnOJIb-
3yIOTCH AHaTepMHH, yJILTpa(HOJIeTOBOe o6JlygeHHe, Ten.mIe BaHHbI
H napa(1HHOTepanH$T B CogeTaHHH c Macca}KeM, npOAOJIbHaa raJTb-
BaHH3aI;Ha, HOBOxaHHOBafI 6JIOKaAa no BHIIIHeBCKOMy. H3 Jlexap-
CTBeHHI.IX BeIAeCTB IIIHPOHO IIpHMeH1IOTCH aCIIHpHH, IIHpaMHAOH,
caJIHIXHJIOBEIfI HaTpffi3 (IIpH peBMaTHgecHHx HeBpnTax), 6poMHAIiI,
CTpHXHHH. C yMeHbTIIeHHeM 6one3HeHHOCTH, a TaHH{e BO BceX cJIy-
gaax OTCyTCTBHfI ee Ha3HagaIOT IIp0BOAHH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OHXOPEPRO3
. Onxoxepxoa - IIapaaHTapaoe sa6oJlesaHHe aomaAeH H OC1OB.
OHO BMaMBaeTc HeMaTOROH (BHJJbi - Onchocerca cervicalis H Oncho-
cerca reticulata) H3 ceMegcTBa Filariidae. OcuoBHble J aHHMe, Hacalo-
IImecfi 6HOJIorHH IIapaaHTa, paccMaTpHBax)TCH B xypCe HHBaaHOaaMx
6oneaHeH. XapaxTep TxaHeBMX HaMeseHHH IIpH ouxogepioae, ocJIOH{-
HeHHH, 'iaCTO HaCTY1I IODUIO B CBHSH C HH4IMHpOBaHHeM, O60CHO-
BaHHH H BM6opy Toro Him nuoro CIIoco6a TepaIIHH B xa}HAOM OTAenb-
HOM. Cny'iae H pyre BOIIpOCM TeCHO BnaeTaIOTC$I B . Hpyr 3aja*i
xHpyprHilecxoI xnHHHHH H Tpe6yJOT ocBenxeHHH B Hypce xHpyprHH.
JIH'IHHHH ronbMHHTa, nonaAai B opraHHaM H{HBOTHOr0, MOrYT
pa3BHBaTbCH B pa3JIH'lHbix TxaHflx. rloJloBO3peJIMe 40pMM o6Hapy-
}xHBaI0T B 4 acgHaIu Imix o6pa3osaHIIHx, B a IIOHeBpOTH'JOCKHX OKOH-
'IaHHfix MMffl] H IIpHnem{an4Hx yHacTKax *6poaHMx xpHll[eH, B Cxne-
poaHpoBaHHOH HJieT'IaTxe, B CTeHHax CJIH3HCTMx H CHHOBHalibHMx
IIOJIOCTeH, B cTBHxax COCyAOB, B CeMeHHHHB noc ie rpy6oro TpaBMH-
poBaHHK ero, B t pyrHX TxaHHx x opraHaxx. OAHaHO ocaoBHMMH
McCTaMH, rAe reJibMHHTM HOHIjeHTPHPYIOTCH B 60JI16IUOM ROnH'IeCTBe,
HBnBIOTCH y'IaCTHH TeJia C TOJICTMMH IIJiaCTaMH H TKMaMH (lH6po3Ho
TKaHH, HCI hITMBaIOll HMH 8Ha'mTeJInHoe HaTHH{eHHe IIpH pa60Te
}KHBOTHOrO H noHoe ero. H TaiHM o6JIacT$IM TeJia nomagu oTHOCHTCH
ammoi-c H xon a (HOHgeBMe OTAeJIM aaTMJIO'gHOOCTHCTOH CBH3HH),
IIHCTb H IIniocua (MeCTO pacnoJiox{eHHH Me}RHOCTHOPO cpeJ[Hero
Mycxyna).. 3A@Cb 'iaMe Bcero H HaxOAgT HBMOHeHHfi, onpeAenIHeMMe
IIpH HJIHHH'IeCHOM HCCneAOBaHHH }HHBOTHMX, IIOpaH{eHHMX OHIO-
IjepxoaoM.
lbo TxaueBoH peaxIjHH (IIpesaJixposalwe HBJIeHHH IIponH()epa-
iwii) nopax{eHHH IIpH oaxoi epHoae OTHOCHTCJI H XPOHH'ieCHHM IIpO-
geccaM. XapaRTepHMe H3MeHeHHH THaaei H HOCJIeAOBaTenbHoe
'IepeAOBa=HHe Hx AaIOT OCHOBaHHe BMAeRHTb IIpH oHxoiRepKoae TpH
IIepHOJ.Sa: HH(1HJI16TpaIuHH, anbTepaluHH H rpaHynHpoBaHHH, IIeTpH-
1HHWXKH.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Hep10A IIH( HJIbTpaiii II eoBnagaeT c nepBOnaqanb-
HbMM pa3Rpa)HOHHeM TJ aHeI3, HoTOpoe pa3BnBaeTCfi c MoMeHTa IIHBa-
311ponaHHa. B npogpacnoJioxceuHH (I16p03HO-BOJIOHHIICTOII TKaHII
H nopaH eHIIIO 0HxOuepHO30M H3BOCTHYI0 pOJIb, HOBIIAJMOMy, HrpalOT
HelOTOpble alaTOMHgCCItHO H ( yHmrHonarIbHLIe OC06eHHOCTII ee
C0CyAUCTOIi CHCTOMbl. Tax, B yqaCTHax npnxpenTleHnsl ( II6pO3HhIX
HyqHOB, IIOCTOHHHO IIOABepU eHHbIx HaTameH Io, 60JIbine Beer0
yU[eMJIHIOTC)l H CJ1;aBJInnalOTCH HOHueBbie BeTBII COCyJ1;OB, LITO MEET
CII0CO6CTBOBaTb oceJ[aHnio JIIITIHHOH. HMeeT 3HaileHne H TO, LITO
[ n6pO3HO-BOJIOHHncTas THaHb, OCO6CHHO B oTReJlax npOnHOl, mnpo-
HoI3 (JHHCauur, JIIIIIIena cnoco6HOcTn Bo3AeI4CTBonaTb Ha TOH HPOBII
H JIIIM()bi aHTIIBHbIM COICpalue1neM CBOIIX BOJIOHOH, LIeM 3J>;eCb H C03-
JJ;aIOTCa 6JlaronpluITHble ycJIOBgl AJI1 pa3BUTua JIIITIIHOH.
BMeCTe C TOM HMeIOTCFI OCnoBaHlg npegnoJIaraTb, LITO JIIITIIIHHII
nocejIHIOTCfi HpeAfO=ITJTeJlbno B THaHHX, rJ(e Menee aRTIIBHbI OHHCJIII-
TeJIbHble np0uecCM HJIII rge TeLIenne Hx Hapylneno B CHJly n3MeneHUI3,
npeJJ:IHeCTBOBaBIHHX nnna3HH. HOJ[TBep JI eHIIeM nocJIeAHeMy cJIymaT
UOCTOflHHO Ha6rno AaeMOe rycTOe 3aceJleHIIe reJIbMIIHTaMu CTeHOH
CJIII3IICThJX CyMOH n cyCTaBHLIX ICanCyJI, oTMeLIalolueecfl no Mepe
HapaCTaHHH npoJln()epaljnn coeJWHlTeJlbHOfl THaHII; yBOjiH ieHHe nx
xoJlltIeCTBa B HJIOTLIaTHe C Ha'IaJIOM ee cICJIepo3a, a TaIC?lie B ToJIIue
3aTbIJIOiIxoI3 CBH3Hn H Rpyrnx THaHeii, Rau pa3 B yLIaCTRax Hx pac-
naga II B norpaHIItHOM nonce rpanyJlnpoBannfl.
AHajiorw rune flBJlenne ycTanaBJIHBaeTCH B M1IHJInHOM xpsiwe,
B KJIeTLIaTICe no ero nepn()epnn H J[pyrnX THaH$JX, rAe n3o6IIJIne
reJIbMIIHTOB HaXOJ1;HT B OLIare Heupo3a H B nplJleu aweH 30He, npH
orpann'IOHHOM ROnn1qOOTBe nX B CMO?HHLIX THaHRX.
PoJlb TpaBMbl II Conp0Bou alolunx ee HapymeHHH upoBoo6palue-
HIIfI B TOM npouecce 6eccnopna. CBH eTeJIbCTBOM 3TOMy CJIyHCUT
3aceJIenne MHOH(eCTBOM reJIbMIIHTOB ceMennlHa noeJIe rpy6oro TpaB-
MnpOBannfi ero II THaHOII B o1py?HnocTII reMaTOM y JIOmagei, nopa-
meHHbIX OHxOI]epHO3OM.
CJla6oe UHBa3npOBaHHO orpaHIILInBaeTCH He3HaLInTeJIbHOH cepo3-
HOI3 1H()nJlbTpaunelI THanen. Hpi IIHTeICIIBHOM nopa?HeHHn nocJle--
HfIH o6HJlbna, a IInorAa, HpoMe Toro, B npHJie?HaiuHx IIOJIOCTHX
CHanJIHBaOTCH 3HCCyAaT, ~ITO nponBJIHeTCHI 3aMeTHbIM IIpIInyXaHIIeM,
Hanpr?IleHIIeM i1O?ICII, ee IIaCTO3HOCTbI0. 3Tn CIIMIITOMbI npII acen-
TIITIeCHOM npouecce nctle3aI0T yxce u 5-8-My AHIO. BbinoTbI B IIOJIOCTU
CyCTaBOB H CJIn31CTbIX cyMon 6oJIee ycTOntuBbI.
HocJIeJ[yIonnan THanenafl peanunfl xapal Tep!33yeTCfl R e r e H e-
paTFBHbIMII II3MeHeHnfnMn B OLIaraX nopa?HennH H npoJln-
( epauuei3 coeAHHl3TeJIJHOiI Txaxu B Hx olfpy?KHOCT1.
HaJIU*lne ICJIy60tl(OB reJIbMIHTOB, COXpaHgioiAHX CBOIO HopMaJlbnylo
cTpyRTypy B d onycax pacnaRa, - npn3naH CTOih1O1 JHU3Hecnoco6-
HOCTII n0JIOB03peJI0i3 (f)OpMbI IIapa3IITa.
Oqarn aGenTwlecHOro pacnaAa taIIWO xa6JIIo aI0TCH B TOJICTbIX
nJIaCTaX BOJIOHHHCTOII ()n6pO3H0n THaHII, Oco6eHHO B rJIy60HIIx Ex
CJIOHX, ileM B ytaCTKax phIXJILIX THaHen. B TOHHHX CJIOJIX ( )H6pO3HOn
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
THaHH (4 aCB;HH, aIIOHespo3bi), a TaHH{e B pbixJIO1 HJIeTLIaTHe Hpe-
BaJIHpyIOT RBJIelHR IIp0JiH4 epaI(HH coeAHHHTe1IbROi3 THaHH.
B TpeTbei CTaAxH OHxor epRo3Horo IIpoi(ecca Ii e T p H 4 H I( H-
p y 10 T C R ogarH IIopa3HeHHH. OTJIO?HeHue co ieH HaAHHaeTCH yHHe BO
BTOPOM IIepHOAe. B yqaCTHax 3HagrTe1IHoro CHOIIJIeHHR IIapa3HTOB,
rAe IIpel1Ae BCero HacTyIIaeT aceIITHgecHHH pacuag THaHeH c o6pa3o-
BaHHeM IIOJIOCTeg, OTMegaeTCR OTJIOHHeHHe rrIb160H coaec B Haxo-
ARII(egCR B HHx roMoreHHOR Macce. C TegeHHeM BpeMeHH IIOCJIeAHRR
CTaHOBHTCR 6OJiee rycT0i3 BcJIeACTBHe yBernHgeHHR HOJIHgeCTBa HpH-
CTaJIJIOB H paCCaChIBaHHR HHHAHOH ee gaCTH. Ror) a 3Ta Macca AOCTH-
raeT ryCTOTbi 3aCTLIBaIOII(ei rHIICOBOH HaIIIHI[EI, B HbI HepeAHO Haxo-
ART HeTp1r nHaTM B 4lopMe yrJiosaTLIX HycogxoB, HHorAa cpaBHH-
TeJIbHO HpyIIHblx pa3MepOB - 90 0,3 x 0,6 CM. LIaiRe me co epHHHMOe
IIOJIOCTH, IIOCTeIIOHHO OHJIOTHeBan, IIpeBpa1(aeTCR B Ho9o6He CJieIIHa
rHuca HeIIpaBHJIbHOE (lopMbl. Erie H B 3TOT IIepHOA HaJibI(HHaI(HH
OHO rierHo OTAeJIReTCR OT I(HaHOTHgHO rHIIepeMHpOBaHHOl CTOHHH.
B McCTax ryOToro pacnOJIOHHeHHR IIeTpH(4HI(HpOBaHHbIx y3eJIHOB
3acTofHao rIIIepeMHR pa3rpaHHgHBaiowei3 Hx THaHH COxpaHHeTCR
H B AaJlbHei3mew, i orAa y3e1IHH yH{e OHOHgaTeJILHO o6H3BeCTBHJIHCb.
BO MHorHx ygaCTHax nopaHHeHHbix THaHeH H oco6eHHO B CTeHHax
CJIH3HCT1Ix CyMOH H B0H oAHOBpeMeHHO C MHOHHeCTBOM y3eJIHOB IIeTpH-
4 HHaI(HH o6HapyiHHBaIOT TaHHHe ToHHHe IIIHypbi 06H3BeCTBJIeHHR
HO XOAy HHTeg reJIbMHHTa B THaHRx.
B CTaAHH IIeTpH4)HHar(HH TKaHH CTaHOBRTCR McHee gyBCTBHTeJib-
HbIMH H HH4eHI(HH, geM B IIpeAHieCTByioII(He Asa IIepHOAa. OgarH
3aHOHgeHHoro o6H3BeCTBJIeHHR B IIOCJIeLyIOII(eM MaJIO H3MeHRIOTCR.
BoHiee HpyIIHbie H3 HHx 06iIgio OCTHIOTCR B THaHRx Ha BCIO HHH3Hb
HHHBOTHoro, MejiRHe H IIOJlocgaTMle pM%JIbie IIeTpH4)HHaTbl MOT
pacCaCMBaTbCH Ha IIpOTR>f{eHHH AJIHTeJIbHOrO CpoHa.
CO CTOpOHMM HOHHH IIopaHHeHHoro ygaCTHa TeJIa B-cBelHHx CJIygaJx
OTCyTCTByIOT HJIHHHgeCHH BMipaH{eHHmIe H3MeHeHHH. IIpH BhICOHOI
CTeneHH HHBa3HpOBaHHH H ii HTOM 3HagHTeJIhHOI3 ABBHOCTH HOHHa
yToiiii eiia, co6paHa B CHJIa4HH, HOHpNTa HOpHaMH 3IIHAepMaJILHblx
HaIIJIaCTOBaHHH, ryCTO yCeHHHiIX McJIHHMH Tpeu(HHaMH. B 6opo3Aax
McHHAy CHJIaAOR IIygHaMH paCTyT ToJICTble, AJIHHHmIe BOJIOCM.'IyBCTBH-
TeJIbHOCTb HOHHH IIOHHHHeHa o IIOABHHHHOCTb ee orpaHHgeHa. HepeARo
B pe3yJl16TaTe pacgecoB o6HapyMHBaIOTCR 3HCHopHar(HH. IIarorioro-
rHCTOJIOriT ecRH IIpI IIIHpOHOM pacnpOCTpaHeHHH H AJIHTeIIbHOM
CyII(eCTBOBaHHH IIpoi(ecca OTMegaeTCH CHJIbHOe yTOJIII(eHHe corium,
rJiaBHMM o6paaoM 3a cgeT 3peJlbix coeAHHHTeJibHOTHaHHbix 3JIeMeHTOB.
HOTOBbie HHere3bi HHCT03HO paCIIIHpeHEI. 9TH H3MeHeiHR xapaHTepHbi
AJIR xpoHHgecHoro Hpo1H4)ep aTHBHOro AepMaTHT a.
B CBeHHHx CJiygaix IIopaHHeHHR OHxoI(epH030M HoARoHHHan KiieT-
gaTHa H HJIeTgaTHa rJiy6oHHx caoeB THaHeH HH4 HJIhTpiTp0BaHM.
OCHOBy IIaTOJioroaHaToMHgecHHx H3MeHeHHII ee B Aa1ibHelmeM HpH
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
acenTHqeCHOM IIpor ecce COCTaBTI$ OT nponH(epai;HH Coe) lHHTe7ImHoE
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
JIaCTH xoJIKH o6MiIHo He yJ;aeTCH :?
06Hapy3KHTb renbMHHTOB B TOnMe
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
B CTOHKY BeHbI OjjlHOiIHbIX reJIbMHHTOB COCyjj OCTaOTCH HPOXOAHMMIM
H coxpaHneT CBOIO 4JOpMy.
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6oIlbnioM IIpOTfl?KeHHH B McH{THaneBblx upoMeHfyTHax H B Hel3 o6pa-
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npn yTnxaHHH 3HCCyjjaT11BHOII peaKi[nn, MHKpo6bi HaxOAHT 61iaro-
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31111, CKJIePO3a TKaHen, xapaKTepa 1H~eHAH11 B03H11KaeT 6oJiee HJIH
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BOJIOHHHCTbIX nJIaCTOB.
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CKJIepO3HPOBaHHOII KJICTiIaTH11 H KaHaHIbI, npoHHKa}Onj11e B ray6nny,
pacmnpnionweca MecTaMn II0 CBOeMy xoj;y 11 y Jana. B 3TOM nepnoge
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najja KJIeTxiaTKn.
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( nuaIH11 IIpH HH4)Hljnposan1H HBJIHCTCH 3aMejjJieHHoe OTTOPHKeHHe
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
MOpTH#AHpoBaaHEaX TKaHOg. OHH B 6oJIbWOM KonHgecTBe aaRep-
MHBaIOTCH B rHOfHbiX HOJIOCTHX. B HexpOT1213HpOBaErHbIX TKaHFIX
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B IIOJIOCTHX H KapMaHax, OTKyAa BbIAeHeHHe 3aTpyAHeHO, IIOCTeIIeHHo
IIpeBpau[aeTCfi B KamHgeo6pa3HyIO Maccy. B yLIacTxax, OTAaJIeHHbIX
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MepHO, Kai H B CnyLiaHX aceIITHqecRoro TeileHHH OHXoI[epHo3a.
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acenTHgecxoro paCIIaAa TKaHeH, B HeM MOHWO yBHAeTb JIHLIHHHH renb-
MHHTOB (H. H. KpacnonepoB).
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B aceIITH*IecnoM anccyAaTe CHH3HCThIX CyMOH XOJKH (CM. BMIIie).
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H caMonpoHaBOnbHOM npopbIBO ciOKyCOB paCIIaAa HHH onepaTHBHOM
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BMeIIIaze7I16CTBe B oTAeJIHeMOM rHOI3HbIx HOJIOCTeI3 H cBHIAeBMIx Haxa-
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oco6eHHO IIpH ciia6oI3 HHBa3IIH. IIpeAnon euuoe CTbIO3pAOM 11ccue-
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xf11TeJIbHbie pe3yJIbTaTbI JI11IIIb B CJIytlaHX 3HaLIHTeJIhHOH AaBHOCTH,
HorAa HOJ1;nefaIImue THaHH ryCTO 3aceneHLI Ha 6o11JTIIOM HPOTH?HeHHH
IIOJIOB03peJIbIMII rejIbMHHTaMH.
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cuoco6, IIpeAJIOHfeHHMIH T. H. HOHOBO11. HpOBI , B3HTyIO 113 HpeMHOIT
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MO}HeT 61JITb IIPHMeHeH JT11IIIb B BeCOHHHe II JIeTHIIe MecsgN, HorAa
MHHPo(1HJIHP1111 HoCTynaIOT B Hp0BL EJIBOTHOFO (H. H. HpacxonepoB).
JTeeeHHe
Oco6e11HOCTII THaHeBLIX 113MeHeH11I3 IIpH OHXOIjepHO3e CBH3aHm
C IIOCTOHHCTBOM (AJIHTeJIbHOCTb) AeiTCTBHH BpeAoxocxoro areHTa
H IIOTOMy TpYAHO IIOAAaIOTCH TepaueBTHqeCHHM BO3AeTHCTBHHM. B IIe-
pHOA 11H~HnbTpaJ[HH BIIOJIHO paI[11ouaabHo paBHOMepHOe cAaBJI11-
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BaHHe THaHe1I C oAHOBpeMeHHbiM IIpHMOHOHHOM CIIHpTOBblX, CIIHpT-
HXTHOJIOBbi% II0BH30H. BOJiee a44eKTHBHO IIpHMOHeHHe rpH3eH,
Top )a B ( opMe IIOAyme'IeK c HarpesoM BengecTBa go 45-60?, IIapa-
~HH0JiegeHHe, BTHpaHHFI paaApa icaionmS Ma3d1, oco6eaao c oAHO-
BpeMdHHbiM IIporpeBaHHeM THaHea. HocJieAHee AocTHraeTca ropHiIHM
IIapoM, amiHIuHpyeMMM Ha HOBep%HocTH xo I(H, IIpHHiHraHHeM Ha
AHCTaHAHH, CBeTO-TernIOBbiM 06JIyHeHHeM, AHaTepMHeg, HOA-HOHO-
4Ope3OM. C HapacTam eM IIponnHC epagHH coeAHHHTeJIbHOH THaHH
yCTOu'rBOCTb IIpogecca B OTHOIIIeHHH CpeACTB H CII00060B TepaIIHH
McCTHoro pa3ApaxceHHH yBeJIH*1HBaeTCH.
IIpH rHoAHOOCJIO)IfHeHHOM TeLIeHHH onxoi;epioaa no aaaHO oIIe-
paTHBHOO BMemaTejibCTBO. I.Jerlbio ero HBJIHeTCH COI BeCTpOTOMHH H
o6eenegeHHe CB060AHOr0 CTOHa OTA@JIHeMoro FHOHHbIS IIOJIOCTBH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OHYXOJIH, HOBOOBPA30BAHPJH (TUMOR,
NEOPLASMA, BLASTOMA)
OHyxOJIbIO HaBhlBaIOT JIoHaJIH3oBaHH0e naTOJIorYILIecRoe pa3pa-
CTaHHe, Bo3HHKaIou ee B pe3yJlbTaTe HenpeprIBHOro pa3MHO}KeHun
113MeHeHHLIX HJIeTOTTHLIX 3JIeMeHTOB onpeJjeJleHHOI3 TKaHH OpraHH3Ma,
o6JIaJ[aionkI3X aHTHB1213Hp0BaHH0fi (opMaTHBHOI3 (yHKI;I3eI3.
YBeji itIeHge 06'beMa y'IacTKa TeJIa gJII3 opraxa HBJIIIOTCH npI33Ha-
HOM 6oJlbmmoro gHCJia IIaTOJIorinecuHx COCTOHHHI3, BbI3BaHHMX TpaB-
MIIpOBaHHOM (reMaTOMM, JIYIM(O3HCTpaBa3aTM), JIoHarIH30BaHHIaM OTe-
HOM, HaROIIJneHHeM axccyjaTa B HOBOO6pa3oBaHHbIx IIOJIOCTHX (a6c-
I;ecObl), IIpOJIH(epaIIHeln coeJjnHHTeJIbHOII THaH1 BCJIej[CTBYIe J[JIII-
TeJIbHOrO pa3RpaHfeHHH (HH(eHB;HOHHble rpaxyJleMbl, CJIOHOBOCTL);
OHO Ha6J11ogaOTCH Hp1 rpmmax, B Hpogecce o6pa3OBaHHH HHCT,
HHCTO3HOro Hepepo?KgeHIIH H T. JZ. Bo Bcex HOAo6HBIX CJIytnaHX rono-
PHT 0 HpHnyXJIOCT1, a He o6 OIIyxoJI1. HCTHHHbIM OIIYXOJIHM CBOH-
CTBOHHbI COI, TOJILHO HM nplncyiwie OC06eHHoCTH.
1. OIIyxOJng MoryT pa3BHBaTbCH H3 JIf060II THaHH, KJIeTOLIHhIe
3JIeMeHTmI KOTOpOH ClI0006Hbl K pa3MHOHfeuIIIo 11 AH epeHI rIp0BHe.
C HapaH;HBaHLIeM KOJIH*IeCTBa Hx yBeJIHiIIBaIOTCH pa3Mepbl OIIyXOJII3.
Bo BCex me CJiyqaux BocuaJIHTenbxbix H3MeHeHHg yBernHtieHHe o6'beMa
TKaHeIi 06yCJIOBJIeHO H0MIIJIeHCOM HBJIeHHI3 - 3i CCygaI[HH, HH()IIJIb-
TpaixHII, HpoJIII()epagHH, BbIpa?HOHHMIX B TOII IIJIII HHOI3 CTeneHH B Ham-
90M OTgeTIbHOM cuIyTiae.
2. XapauTepHOI3 oCO6eHHOCTbIO ollyxoJleln HBJIHCTCH a T H II H 'I-
H 0 C T L CTpyHTypbl no cpasneHi no C TKaHHMH, gaBIIIIIMH Ha*IaJIo
6naeTOMaT03HoMy pOCTy; onyxo eBble KJIOTHH BechMa pa3Hoo6pa3HLI
IIO (OpMe, BeJIHTnHHe, pa3MepaM HRep H CH0006HOCTH BOCIIpHHHMaTb
KpaCKH (n o JI H M o p( H 3 M).
3. OnyxoneBbiI3 POCT HenpepbnBeH. OH HpoJjonMaeTCH, Korga
onpegeJIeuHan HpI4TIHHa, HOCJIy1KHBIIIa$ TOJILIHOM K ero HauaJIy, y11O
yCTpaHOHa. Bo Bcex gpyr1x CJIy*iaHX rHHepnJIa3HII, 06yCJIOBJIeHHOI3
HH(eHAHOHHMIM HatIajIOM, reJIbMHHT03aMH, 3HA0HpHHHNMII pacCTpoll-
CTBaMI3, (IyHK9HOHaJIbHNIM1 HapyiIIeHHHMH TpaBMwieCH0r0 HpOliC-
YO}KAeHgH H T. g., c HpexpaIl;eHIIeM AelCTBHH HpllWHHOro ( aKTopa
pa3POCT TKaHII paHbmIIe HJIH II03lHe oCJIa6eBaeT H B HOCJIeJZyIOHleM
HpHOCTauaBJIHBaeTCH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
4. Ha iaJImHue CTagHH 6nacToMaTO3Horo pOCTa B rpOMaJJHegmeM
6OTIbmHHCTBe cJlyqaeB He H OHBTIfilOTCH CHMIITOMaMH, yJiaBJIHBae-
MbIMH IIpH HJIHHHgeCHOM HccJIegoBaHHH MHBOTHoro. YBenHgeHHe
o6beMa, HaH OCHOBHOg, IIO3RO BLIPHCOBNNBaIOWHgcH Hpg3HaK, 8a-
gaCTyIO 9JIHTeJIbHOe BpeMJ oCTaeTCSI egHHCTBeHHNIM noRa3aTeJIeM
aa6oueBaiHg. HepegKo npogecc IIpoTeKaeT 6eCCHMIITOMHO B TetjeHge
BceR )KH3HH H{HBOTHoro. ApyrHe aa6owleBaHHH, -conpoBoR gaIon;HecH
yBeJIH,qeHHeM o6'beMa TKaHeg H QpraHOB, paHbme 'HJIH IIO33He Hpo-
IBJIfiIOTCH MHOrHMH HJIHHHLIecHHMH CHMIITOMaMH.
B M O p( O a o r H g e c K O M OTHomeHHH ouyxonH KnacCH(H-
I(HpYIOT COOTBBTCTBeHHO TKaHHM, H3 KOTOpIJX OHH pa3BHBaIOTCg:
aIIHTeJIHanbHOro npoHcxoR eHHg-IIaJIHJiOMa,aJ;e-
HoMa, paH; COeJ;HHHTeaLH0TKaHHoro-4)H6poMa,, nH-
noMa, MHKCOMa, xOHgpoMa, OCTeoMa, capKOMa; M Li in e i H O r o-
JIeg0MHOMa, pa6gOMHOMa; 0 0 C y J[ H C T O r o- reMaHrHOMa, nHM-
I aurHOMa; Ha H e p B H 0 g T K a H H- HeBpoMa, raHOMa H T. J(.
KpOMe Toro, no MOp(OJIOPHqeCKOMy npHHiwny paaJiHmOT II p o-
C T bI a OIIyXOJIH, COCTOBIIuHe H3 OJXHOg TKaHH (( H6poMa, MHOMa),
c m e m a H H bi a ((116po-MHKCO-xoH9poMa, ( H6po-xoHJ(po-ocTeoMa)
H c JI 0 3I{ H bi a (TepaToMa). (Boupoem Mop(o,IorHH oIIyxoneg
1IOJ[po6HO paCCMaTPHBaIOTCH B Hypce naTOn0PHgeCKOi3 aHaTO-
MHH. )
IIo HUHHHge CH OMy TegeHHIO OIIyXOnl genJT Ha
JX06p0HagecTBeHHbie H 3IOKaqeCTBeHHLIe.
A, o6poHagecTBeHHag ouyXOnb (neoplasma be-
nigna) - rOMOTHIIHgHoe 1EIOBOO6pa3OBaHHe. Ee KneTOnHiae aneMeHTbi
AOCTHraIOT 3HagHTenbHOH CTeIIeHH apeUOCTH. XapaITepHbiM BBnBeTCH
CpaBHHTenbHO MOJ[neHHIIH a u C II a H C H B H bI g p 0 C T TaHHx
onyxo ie i. OKpymaIOII;He TKaHH IIpH ATOM OTOABHraIOTCJI B CTOp0Hbl
H HeuOCpeACTBeHHO C ouyxonbio He CpaCTaIOTCH. BOnbme Toro,
J(06poIageCTBeHHLIe OHyXOnH 6MBaIOT iaCTO 0TrpaHHgeHLI Hancynog
(HanpUMep, JIHHoMa), aerno OTgengeMOg B upogecce onepaIIHH or
npgneHcawx THaHeg; OHH He gaIOT McTaCTasOB.
06igee COCTOIHHe IHHBOTHOrO BO BpeMg JOCTa go6poxagecTBeH-
HbIX onyxone8 He H3MengeTCg; HeT HapyIIIQHHI3 o6MeHa BenxeCTB,
COCTaBa HpOBH; HOpManbHNNMH OCTaIOTCH nnM(aTHgecRHe y3nbl.
OJxHaxo IIpH noxanHaai nn Ao6poxagecTBeHHoIi onyxonH B Abi-
xaTenbHbix IIyTBX, B cepJwe, B Moire y aa6onesmHX }KHBOTHLIX
He HCHnIOgeH neTaHLHMMH HCXO9 BcaeJ;CTBHe rny6onnx (yHKIIIIOHanb-
HBIX HapymeHHI3 aTHX opraHOB. Tgmenble oCJIO}KHeHHg MOryT Tan]Ke
B03HHKaTb, norga onyxonb c)LaBnrBaeT Hpy]Hbie COCygBI, HepBHiae
CTBOJILI, Tpy6gaTLIe opraHbl (HHmegHHK, MOgeBLie IIyTH) Hir, cMe-
n agCb, OMepTBeBaeT BCne) CTBHe IIpHxcaTHB IIHTaIOII(Hx ee OCHOBHLIX
coCygOB.
3 a o H a g e c T.B e H H a a o IT Y X O n b (neoplasma maligna)
xapaRTepU3yeTCg I1Hl H ILTpaTHBHLIM pOCT0M, T. e.
BHe) peHHeM onyxoneBNNX TBH{8H Ha pa3JIn Hyio rny6Hny H B pa5EMX
HanpaBnennBX B CMeIRHO ne}Kanme TKaHH.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
OC06eHHOCTII0 3JIoxatIeCTBeHHoro pocza $IBJIHeTCH M c T a C T a
3 H P 0 B a H n e. OIIyxoJIeBble HJIeTHH, HepeHeceHHnIe B gpyrHe
ytIaCTHH TewIa, gaIOT Ha'Ia7Io poCTy HOBLIX OIIyxonneI3. B o6iiaCTH
IIpoMe?HHOCTH, B naxy HepeAKO Ha6JIIOAaIOTCFi HMIIJIaHTai;HOHHLIe
McTaCTa3bI, KorJ[a H3 H3BJIeHHaf IIOBepXHOCTb paHOBOH 0IIYXOJIH
coIIpHHacaeTCH C IIOCTOHHHO yBJIaMHeHHOH, MaIrepHpOBaHHOH H0H
COCOgHHx y'IaCTHOB. TaHHe MCTaCTa3LI LIaCTO Bo3HHHaIOT Ha XBOCTe
y co6aR H JIoIIIageI3 IIpH JIoKa3IH3agHH IIepBHLIHOI3 OIIYXOJIH B aHaJib-
HOH o61IaOTH. McTacTani MOryT IIOFIBHTbCH TaHHfe B pa3JI1TTiHbIx
yTiaCTKax paHbl Bc3IeAcTBHe IIepeHoca HJIOTOH 3JIoHa'IeCTBeHHLIX
olyxo ieii IIpH oUepaTHBHOM ygaJIeHHH Hx.
IIpH 3JIoRa'TecTBeHHbix o1yXOJI$TX o61ITIHO pa3BHBaeTccI K a x e H-
C H H. OHa o6yCJIOBJIHBaeTCFI B OTJje3IbHhIx cJIygasix IIOBTOpHNIMH
Hp0BOTe-4eHHf1MH H3 cocy);oB pacuagaion eucH OIIyxoJiH. IIpH JIopa-
HfeHHH IIHH[eBapHTeJthHNX HyTel, IIe'TeHH, IIOJ[H(eJiyg0uH0II ?He3Ie3b1
HaxeHCHfi B TOM HJIH HHOH CTeIIeHH CBH3aHa c paCCTpOIICTBaMH aKTa
IIpHeMa HOpMa H IIHH[eBapeHHH. IIpH rHHJIoCTHOM pacnaJ[e OIIyXOJIH
Ha opraHH3M IIary6HO BJIHfiIOT BcacbIBaIOIIwecH ToHcHLIeciHe -BeHxe-
CTBa, B03MO?HHO Tal?Ke cIIeIZH(HHecKHe TOHCHHII OIIyxOJIeBOM THaHH.
OcHOBHIIe IIpH3HaHH HaxeliCHH (HcxygaHHe, o61gaq ciia6ocTb, rHIIO-
xpoMHaa aHeMis) B oAHHX CJiyTIaHX o6Hapy?HHBaIOTCfI cpaBHHTe3Ibxo
paHO, B L pyrHx OHH OTCyTCTByIOT Ha rI OTfl?HeHHH AJIIITe3IbHOro cpora
CyII[eCTBOBaHgfi OIIyXOJIH H pa3paCTaHH$1 ee go 3HagHTeJIbHbix pa3-
MepoB.
B OCHOBe CyIIIeCTByIOIIJHX TeopHI3 Bo3HHKHOBeHHFI H pa3BHTHH
onyxoJleg JIe?HaT TpH (aKTopa: J;HCTOIIHH 3apogblmesbix HJIeTOK
(TeopHfi HOHrelra), xpoHHTlecxoe pa3Apa EeHHe (Teoplx BHpxosa),
Bo3gei3CTBHe Ha OpraHH3M HH(e1Z;HOHHbIX HJIH IIapa3HTapHbix areH-
TOB.
CorJIacHO TeopHH KoxreliMa, Hagajio poCTy BceX ouyxo ieI3 ) aIOT
H36MITOLIHbie 3apogLlMeBbie HJIeTKH HJIH me lJIeTHH, CMeCTIIBHIHecn
B paHHHe IIepHOALI 3M6ploreHe3a, yTpaTHBHIIIe HOpMaJlhHble B3aH-
MOOTHOIIIeHHfi C OCTaJIbHhIMH KJICTOTIHhIMH 3JIeMeHTaMH. OHH He
IIpHHIIMaIOT yTIaCTHH B TKaHeo6pa30BaH12IH IIJIOga H J[JIHTeJIbHOe
BpeMH OCTalOTCH B gpeMJIIOmeM COCTOHHHH; B J1;a3IbHelmeM IIOg BJIHfi-
HHeM BHeIIIHHX TpaBMaTHTIeCHHX B03JI,OHCTBHH HJIH 3HJ[OKpHHHbIX
HapymeHHI3, B03HHKaIOHjlX B pa3JIHTIHbie IIepHOghI ?KH3HH MFIBOT-
HOrO, 3TH KJIOTHH B16IXO9$IT H3 JIaTeHTHOrO COCTOHHHfI; HX IIOTeH-
IOHaJIbHafl 3Heprwi poCTa BbICBo6O?KJ[aeTCH, H HaTIHHaeTCfi 6ypHafi
HpOJiH(Iepaz;Hfl MaJIogH((epeH1;HpoBaHHhIx HJIeTOK OIIyxOJIH.
flpHHgHIIHaJibxoe 06oCHOBaHHe 3T0I3 TeopHH pa3BHT1V[fI OIIYXOJIefl
(HeO6XOAHMOCTb 3apogbiIIIeBoro 3atIaTHa) 61IJIO IIOKOJIe6JIeHO B 3Ha-
TIHTeJIbHOH CTOIIeHH J[aHHbIMH 3KCIIepHMeHTasI6HOH IIaTOJiorHH 110
MCHYCCTBeHHOMy IIOJIyTTeHIlIO paROBMIX onyxOJIen3 B JII060M yTIaCTKe
HO?HH ?KHBOTHNX, HoJ[BepraeMoM J;JIHTeJIlHOMy pa3J[pasfeHHIO MHO-
rHMH xHMHTIecKHMH BeugeCTBaMH. B 8TOM cJiyTiae I HCTOIIHH, 6e3-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
ycJIoBHo, no HrpaIOT poi Haga m oro sa'ama. To me caeAyeT oTMe-
THTb B 0THomeHxK paKa, paauiBamerocR Ha pyxax y peHTreaono-
roB, i orAa OHH npese6peraloT MepawK aau mz upn IIpoAOamKTennHOH
pa6oTe B peWTresoscROM xa6wHeTe.
TeopHR AHCTOIIHE rpy6o. yupou aeT 6HoJIorIeecxR i IIpoitecc,
CBOAR ero CJIO2MHOCTh K IIpegcTaBneHHio o6 maMeHeRma EJieTOR B opra-
HHaMe, KaI{ mnoroxneTO'moM rocyAapcTBe*. McTOAOJIOrH%iecxK He-
BepHO H TO, 'I TO CaMH 43a6JiyAHBmHecHU KJIeTRH HaAeJieHM OCO6bIMII
BHyTpeHHHMH cTHMyJIaMH, He aaBHCHE HMH OT I OJIOCTHOro opra-
HH3Ma.
3Ha'IeHHe HepBHOH cIICTeMIJ H oco6yio pom ROpbl rOJIOBHOrO
Moira B pa3BHTHH oIIyxoJIeg HeOAHOKpaTHO OTTOHRJIH P. A. 3axapbiH,
H. A. BeJIhHMHHOB, C. H. (DeAopoB H pyre BHAHbNe AeHTeeJig oTe-
9eCTBeHHOg McARAR-AYI. M. K. IIeTpOBa Ha OCHOBaHHH MHoro'IHcneH-
HIIX 0IISITOB, IIOCTaBneHHIJX B IIaBJIOBCIOH na6opaTOpHH, 6necTifn e
AOKaaana, 'ITO IIOBTOpHUIe HepBHIIe TpaBMIi H caeACTBHB Hx - -RcpblBblw
HepBHOH AegTenbHocTH COIIPOBOHKAaIOTCR Bo3HHKHOBeHHeM HOBO-
o6pa30BaHHi BO fHyTpeEHHx opraaax m KOH(O.
,TeopHR paaApa)KeHNR (HppITaTKBHaH) Bxpxosa IIpeAycMaTpH-
BaeT B RaeeCTBe IIpngHHHOrO ~aXTOpa OIIyxOJIeH CYW CTBOBaHHO
CIIOIXH(2H'ieCKHx pa3ApalxHTenei, CH0006HMX IIpH A ITe ThHOM .Boa-
A0i3CTBIIH CTHMyJIHPOBaTb )OpMaTHBHyIO (IyHKAHIO xJIBTOK. K TaKHM
KaHI;epOreHHbzM B9IT;eCTBaM OTHOCRTCH: napa41HH H IIpOAyKTbi Hepe-
roHxn xaMe$Horo yr i , , 06yCJIOBRHBaiomBe R0HBneHHO paxa KOH{H
Y' RIOAeg; MbimbHKOBHCTO-KO6an16TOBbie COOAHHeHHR (paK neri Hx).
B IIPHlIHHHyKO CBH3b c xpOHII'IeCKIIM pmpameHmm CTaBRT Tax}Ke
IIpeBparL eHHe B3B }KenyAKa, KHme9HHI{a H KOH{II B PaEOBYI0 OIIyxonb,
pax peHTreI;OJIOrOB H ApyrHe CJIycaH Korb aa6OJIeBaHKq.
B BTOII TOOPHH Ta me HenoCJIeAOBaTenbHOCTb H TaROe me McT090-
HOrH'IOCKII HeBepHOe IIpeACTanaeHHe o IIpoi(eece (B OTPUUBe OT genOCT-
Horo opraHIIaMa).. CBHab Me wiy pasApameHHeM KO}KH HJIH nerxIIx
H Ha'IanOM OIIySOJIeBoro pOCTa OTHIOAb He CBH;AeTORbCTByeT 0 TOM,
'ITO HMOHHO OTOT paaupaHcHTenb, Kaxosa 6bi Hg 6bina ero npHpoAa,
RBngeTCR caMMOAOBneIOIIglM ()aKTOpOM, npeAonpeAeIRIomHM paaBH-
THe xneTOH C 0006LIMH CBOIICTBaMII. TeopHR BHpgoBa 06XOAHT BOIIpoC
O pa3BHTHH paKOBOIi OIIy%OJIH B Tex cayiiaHx, Kor)a IIOHBaeHHIO ee
He npeAmecrByeT HH X OHH'ieCKOe BocnaneHHe, HII BJIHRHHe BHeHI-
Hag paaApaNMTelfeg, a Tanwe npo6JieMy o Bpo)HAeHHUX onyzoiRx
H o BceH rpynHe Ao6poxa'eCTBeHHMx HoBOO6paaosaHHI.
Hpelwo2loH{eHHe 0 iiapa8HTapHOM HIH HH(IeKI;HOHHOM IIpoHC-
XO?KAOHHH oIIyxOnei 06OCHOBLIBaeTCH MHOrHMH Ha61IIoAeHHRMH II
BRcHepHMeHTanbHbiMH AaHHbIMH. HexOTOpMe Ha HRI aaCnyMHBaIOT
yIIOMHHaHHH: y xpynHoro poraToro CKOTa -- pax IIe'IeHH IIpH (~aC-
IIHOneae, y co6ax H xomex - npH orHCTOpgoae; y pbi6, B iaCTHOCTH
y 4 openH, Ha6nIOAaIOTCH 31HBOOTHH paBOB0i3 OUyXOnH WRTOBHAHOH
?xeneabi; y cepblx KpuC, xorAa ag xopMAT 'IepHbIMII TapaxaHaMH,
imamoW.HMHCH HpoMe}xyTO'IHIIM X03HHHOM HapaaHTa Spiroptera
neoplasmatica, pa3BHBaOTCH pax R3LII{a x x{enyARa.
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
BOJIbmylo poiIb B BO3HHKHOBOHHH OHyxOJIei3 OTBOJ(HT ~HJIbTpylo-
II;HMCH BHpycaM. ix CLIHTaIOT 9THOJI0rHgecRHM (I)aHTOPOM capno
y Kyp H yTOH, HauHJIJIOM poraTOrO CKOTa, co6an, xpoJrHKoB, a Tann e
ueJIOBexa, paxa MOJIOLIHOH ;1 e1Ie3hI MiilmeH, paxa HogeK JIHryIHen,
HOEOTOpLIX oHyxoJleg pb16 H HaceHoMblx. H. (D. FaMaJlea BbIcHa3bl-
BaJr Hpe)uio ioxceHHe o JIaTeHTH0M COCTO$IHHH ( HJIbTpylomerocn BH-
pyca B opraHH3Me, o6 aI{THBH3aIJHH ero HpH HeHoTOphIx, HeH3BecT-
HbIX 06CTO$JTeJIbCTBax, qTO conpOBoa aeTCH OHyXOJIOBbIM pOCTOM.
B nocaeAHee BpeMH pa60TaMH A. A. THMo()eeBCKOro, j[aHHbIMH
JI. A. 3HJIb6epra, ero COTpyAHHHOB 11 JxpyrHMH coseTCKHMH HCCJle-
goBaTeJrHMH BCHpbITbl BOJHHble (anTbl, Ho3BOJIHIomHe roBOpHTb
o HeROTOpLIX cBOI3cTBax 9THX BHpycoB.
1. BHpyc, BLIgenIeHHb1iI H3 HaIHJIJIOMbI KpoJIHKa, Bb13LIBa10IgHr3
9Ty 0HyX0Jrb HpH 9KC11epHMeHTaJIbH0M ero BBej[eHHH, He o6Hapy-
)IfHBaeTCH HOCJIe HpeBpaMOHHH HaHHJIJI0MbI B paHOByIO OHyXOJrb.
On MacKHpyeTCS.
2. OHyXOJIH, Bo3HHKa1orr ue B pe3yJIBTaTe pa3gpanfeH121H KaH-
IjepOreHHbIMH BeIJeCTBaMH (JIyquCTag 9HeprHH, ropMoxLI, KypiUblil
6enon H T. H.), TaKxce coZ(epanaT B ce6e BHpyc.
3. BeJIKOBbre HpOgyHThI onyxo iei3 fIBJIIIIOTCfa HOCHTeJIIIMH c11e-
AH(HgeCKHx alTHreHOB, KaKHX HOT B 390 OBMIX THalax.
4. B 9KCHepHMOHTe yJ[aeTCfi HOJIy'IHTb HMMyHHTOT B OTHOIHeHHH
onyxonenoro BHpyca; HpH 9TOM, OJAHano, He B}Ipa6aTbIBaeTCfl ycTOi3-
'IHBOCTH Ic TpaHCHJIaHTHpyeMLIM oHyXOJIeB1IM HaeTKaM.
5. (DopMaJIHHH3HpoBaHHble JIH3aTb1 oHyXOJIeBOH TKaHH B ancue-
pHMeHTe gaIOT BbipaH OHHb1H HMMYHHTeT K HOCJIOJ[yIOIIJHM HMHJIaH-
TagHHM COOTBOTCTByIOII;eI OHyXOJIOBOH TKaHH.
TaHHM o6paaoM, coBeTcnan OHHOJIOrHH BLIHIJIa Ha HIHp0Kyi0
gopory H3LICKaHHi3 B o6aaCTH HaToreae3a OHyxoJIeH. Ha,BTOM HyTH
OTHpblBalOTCH B03MOMHOCTR C0BepIHeHCTB0BaHHFI gHarHOCTHKH H
pa3pa6oTKH McT0J[0B Hpo(HJIaHTHHH peHHAHBOB HpH 3JIoKaTIecTBeH-
HhIx HoB006pa3oBaHHHx.
)jH(l( lepeHI;HaJIbHaH gHarxoeTHBa
OHpeJ;eJIHTb HpHpogy Hpor ecca, T. e. YCTaHOBHTb HaJIHTIHe OHy-
xonIH y 6onlbxoro HfHBOTHoro, He Bcerga JIerno. EH;e CJIOHfxee POIHHTb
BOHpOC o xapanTepe HoBoo6pa3osaHHfl B KOHHPOTHOM caygae (Ao6po-
Ka,IecTBeHHoe OHO HJIH 3JIonaLIecTBexxoe). HpH Bb1HCHeHHH 9THX
MOMeHTOB ygHTbiBaeTCH p31A 06CTOJITeJIbGTB.
JE O K a a H 3 a u jun. Rorga HepBH4HbII3 oar oHyxoJlesoro pocza
J[OCTOBepHO ycTaHOBJIeH, BO MHOI'HX CJryganx HpeJ[CTaBJIHOTC11 B03-
MOMHbIM CyJIHTb 0 TKaHesol3 CTpynType OHyxoJIH: Ha none HJIH
CJfH3HCTOH o6OJIOgne o6N Ho pa3pacTaeTCH 3HHTeJIHOMa; B IIOAKOM-
HOIT KJIeTLIaTHe - JIHHoMa (pHc. 124); B CTeHKe MaTHH - MHoMa.
(D o p m a o u y x o a H. Ao6poxageeTBeHHbMe onyxoan 6LIBaloT gaHHe
onpyrJIoi3 (IopMbl. TaHHMH HpegCTaBJIHIOTCf1 (H6pOM1I (pHC. 125),
JIHHOMM, MHOMbI. HanunnoMa Merino 6yrpHCTa, HMeeT BHJX ABeTHO11
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
HanyeTbl (pwc. 126 H 127). rpaHrn uu Ao6poxagecTBeHHblx onyxoneg
CTpOFO ROHTypHpOBaHM (pne. 128 H 129); a noltagecTBeHHble HoBo-
o6pa3OBaHHH B McCTe IIepexoAa K HOpMaJI16H1SM THaHHM
TaHHx geTKBx rpanHA (pHC. 130).
Pgc. M. a 6poMa ry6m. No. 126. HangnnoMu HpagHes gnoTf
P a a M e p b I o II y x o n H. HepBHYHuue ogarH pocza o6e ix rpyrn
onyxoneg BHagane HMeIOT orpaHHgeHHme paaMepm. C TegeHIIeM Bpe-
McHH Ao6poHagecTBeHHIae onyxonH MoryT AocTHraTb orpoMHoro Beca
357
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
(y co6ax Ha6nIo;xaIOTCx BayTpH6pIOIIIHbie JIHIIOMBI TaRoro TI{e Beca,
xax H CaMH HOCHTe7IH Hx). Bec MHOM MaTRH Y I{opOB H CBHHeg HepeAHo
PHe. 127. nammnnOMaTOa yqacTxa xox{H Pic. 128. Tsepgaa IIammn-
co6axH. noMa Ha yaxoM ocaosaHmm.
oupej[eJiaeTCH IIygaMH. B rpyHHe anoxaqecTBeHIIMX OIIyxoaei3 BecbMa
6oJIbIII$x pa3MepoB HHor) a J{ocTnraeT MellaHocapxoMa ce1le3eHHII
PHc. 129. HanHnnoMa na IIIHpoxoM
ocHosaHIH.
iomageI3 H ageuoMa uo%KH.
OTHommeHHe it IIpegTia-
raIOHSHM TxaHJM. 1o6po-
i a4ecTBeHHble oiiyxojiH, game
B TOM CJiytiae, xorga OHH 6OJIhmOI3 BeJIHTIHHLI, IIPH IIacCHBHOM cmeme-
HHH UO BH}I{HbH B 6OJiee win McHee HIHpoIIIx rpaHHuax. 3TO o6yCJioBJIe-
HO Hx 3I{cuaHCHBHnIM pOCTOM. 3JloxaiiecTBeHHble olyxo3IH cpaii euri c
IIpHUe3xaMHMH THaHHMH (HH(HJIbTpaTHBHIIH pOCT) H CMergaIOTCH
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
TOJI16HO B IIpegenax IIOABHHHHOCTH onpeAejteHHbi3 TxaHeBIZX n iac-
TOB (BMeCTe C HHMH).
110 B e p x H o C T b o u y x o JI H. HCc IeAOBaHHe (IIaJIbf aIUHH) IIOBepZ-
HoCTH ouyxoJIeH HMeeT BaHKHOe aHa'ieHHe IIpH rmy6oxoH JIoKaaxaaIwHH
HZ. ,I(o6poxa'ieCTBeauiue onyxo 'tame HMeZOT rJIaAKylo fOBepx-
HOCTb. MoryT 6EaTb xpynHEie 6yrpu 8 OrpaHHilOHHOM 1OJIH'ieCTBe,
'ITO xapaxTepao Ann nnuOM. 3JloxatiecTBeaHMe OIIy%OJIH 06bI'1H0
6yrpHcTbl (p'c. 131). L orAa ycTaHaBJrHBaloTcH BslnawgHble yiacTHH
olyxo3iH B (opie 6yrpoB 6onee 8Ha'mTeJIbHblx paaMepoB, oHH TarHxe
HepoBHrle, yceaHbi McJIHHMH 6yropxaMH (pHc. 132).
KOHCHCTeHq Ha oIIyxoJIH. BOJIbmHHCTBOonyxOne I aHaw-
TeJIbHOa IIJIOTHOCTH OTHOCHTCH x rpyIIIIe Ao6poHa'IeOTBeHHbi% (ocTeoMa,
xon poMa). PaBHOMepHO IIJIOTHbl H aJIaCTH'IHuI BO Bcex CBOHZ y'laCT-
xax (H6poMM; MHrKoi HoacxcTenIgHH - MHxcoMbi, allrHomm, nix ombi.
XapaxTepao$ .ooo6eHHocTbio HZ SBJIHeTCH Tax Ke HpCO supaHiceaHan
BnaCTWMO Tb. 3TH ouyxoJiH nerxo HsMeHH1OT CBOIO (OPMy HpH
CHHaTHH H BHOBb fl E MMIOT ee c IIpexpaIISeHHeM j(aBneHHA. 000y-
J{HCTbie onyxojim CHxnMazoTCH, yueHbmaacb B o6%eMe; aUrfOMW He-
peRKO nyJIbCHpyIOT.
B rpyIIIIe 8noxaq$CTBOHHMZ oIIyXOneH MSrxyIO HOHCHCTeHI(HIO
HMelOT xpyrnoxneTO'IHble capxoMbl. ORHai o, B OTJIHgHO OT j406po-
xa'iecTBeHHbIx MHrHH% HoBoo6pa3oBaHHa, oHH He anacTH'wbl, xpyfIII
H Ae4IOpMHpyIOTOO HpH CAaBJIHBaHHH. TaxHMH We cBOacTBaMH o6Jia-
AaeT pax-MOarOBHx; cicHpp, Hao6opoT, IIJIOTHOH KOHCHCTeH$IIH.
Pne. M. Pax cpamzsla ry6.
859
I
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
CocTOHHHe onyxoJIII B IIpOI;eCCe pocTa. F,o6poxailecT-
BOHHble oIIyxoJIH, pa3pacTaacb AJIHTeJlbnoe BpeMH H yBeJIHiIHBaicb
B o6'beMe, He HpeTepueBalOT gereHepaTHBHbIx H3MeneHHI3 H He
pacnagaIOTCf. HeKpoTHnecHHe H3MOHeHHH CO CTOPOHLI HX IIOBepXHOCTH
*3aCTo 61JBaIOT CJIOACTBHeM UOBTOpnorO TpaBMHponaHHH. Pacnag B rJly-
61,IH0 HJIH me BceI3 OIIyXOJIH MO?R T HaCTy1HTb B pe3yJlbTaTe MexaHHw-
CHHX IIOBpemAeHHH, cOnpoBou alouuHXCH HapyineHHeM IIHTaHHH.
)IJiu 3JIoRa'IeCTBeHHhIx onyxo ieII xapaKTepeH pacuag THaHH
c o6pa3OBaHHeM H3B (pHC. 133 n 134) HJIH IIOJIOCTeII B TOJIII(e HOBO-
o6pa3onannH, 3alOJIHHIOn;HXCa 11il1 U HM, MYTHLIM Co ep EFMLIM.
B onyxoiiax, 06JIaRaioigHX xopomo pa3BnTOII cTpoMOII, pacnaJ.[
HagHHaeTcu IIo3 Re H nporpeccnpyeT McgJieHHee, gem B 6LICTpo pacTy-
PKc. 133. PacuaR paxosoii
OIIyxOJIII.
Pnc. 134. 14aLi3BJIenabIB pax
KO B Y KOIIIKH.
H(HX 61IaCToMax, oTJIH*IaioiilHXCH BhICOHOI3 3JIoHaqeCTBeHHoCTbIO. HaR
H3BeCTHO, TalHe OnyxOJIH npoHH3aHrI ryCTOH CeTbIO MHPOHHX 000y-
ROB, CTeHHH HOTOPhIX HanoMHHaIOT C06o1 CTeHHH KannJIJIHpOB. OHH
JIerro pa3pbIBaIOTCH game upn cMeu eHHHx onyXOJIH no BpeMH ABH-
HfeHHa HfHBOTHoro. Hp0BOH3JIHHHHH B TaRHX onyxOJiHx - O6LITIHOe
HBJIeHHe. OnH Cuoco6CTByIOT pacnaay IIapenxHMbl H CTPOMEI HOBO-
o6pa3oBaHHH OIHOnpeMenno in 6OJIbmOM ..,IIpOTa?HeHHH.
F OunilecTBO nepBnqHblx o'IaroB pocTa. OAHOnpeMeH-
Hoe nOHBJIeHHe MHOPHX ogarOB onyxoJlenoro pocTa CBOHCTBeHHO B
6oJlbu leII CTereHH Jjo6poKageCTBeHHbIM HOBOo6pa3OBaHHHM. IIPHMe-
POM B 3TOM OTHOIIIeHHH CJIy}K1T nauHJIJIoMaTO3 HO1KH Y KpyrHoro
poraTOro CKOTa H CJIH3HCTOIH 06OJIOgRH IIOJIOCTH pTa y co6an;
HepeAHO B Tetienne caMoro HOPOTKOrO CpoKa 1OHBJIHIOTCH AOCHTHH
H COTHH 6opojaBOH. MHoroTIHCJIeHHb1 TaH1Ke B 6OJIbmIOM tlncJle cJIy-
siaeB nepBHiIHbie JIHIIOMbM y co6aR.
OTHIOAb He ncnHIogaeTCH OJWOBpeMeHHOe HJIH HociiegonaTeJlbuOe
pa3BHTHO OIIyXOJleH HeCHOJIbnHx THROB B OAHOM HJiH MHOrHx opraHax
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
oAHoro H Toro xce }KHBOTHoro. 'qau;e Bcero TaHHe cogeTaHHH Ha6Jno-
J(aIOTCH Y C06ax, HaupIMep MHKCO-XOHApO-OCTe0-CapKOMa MOJIO1ROH
}Keueml, aAeHo-41H6poMa MOJIOqHOg }KeJle3bl, JIHIIOMII - B IIOAKOM-
HOH KJIeTgaTHO H B IIOJIOCTH ,R BOTa, c H6pO-MHOMa MaTKH, c H6poMa
BJIaraJTHlga H MHKCO-XOHApO-OCTeo-capxoMa BbIMeHH (T. M. IIOHO-
MapeIKo). 3JIOKageCTBeHHMe HoB006pa3osaHHq pa3BHBaIOTCH upeHMy-
u;ecTneHHo H3 oAHHOqHOro r epBHmHoro aailaTKa.
McTacTaaHp0BaHue. B Boupoce AH epeHIxIaAHH 3JIo-
Ka,qecTBeHHbIx ouyxo iel3 cyT1 eCTBeHHOe 3HageHHe HMeeT ycTaHoBJIe-
HHe IIyTel McTacTa3gpOBaHIIH HX B IIepHOA pOCTa, a TaH}Ke B CBH3H
c ouepaTHBHmIMH BMemaTeJIbcTBaMH.
HapItHHOMNI 06bltiHo McTaCTa3HpyIOT JIHM(aTHgeCKHM IIyTeM. IIpH
3TOM BTOpIgHble ogarH aJioRageCTBeHHOrO poCTa o6Hapy}KHBaIOTCa
B perHOHaJIbHMTX JTHM4 aTHgeCKHX y3JIax. Hepexoc capKOMaTO3HMX
KJIeTOK gauze IIpOHCXOAHT TOKOM BOHO3HOH KpOBH, c McTaCTa3aMH
B opraHIl, oTAaJIeHHMIe OT IIepBIIgHoro oqara. HepeAKH cilyga1 uoua-
AaHHH capHOMaTO3HLIX OIIyXOJTeBblx KJIeTOK B 6oJlbuloH Kpyr KpoBo-
o6paH;eHHH H AaJImHeI3IITero nepeHoca ux apTepBaJlmHOl KpoBbIO.
TaIOB IIyTm McTacTa3a B paAy}KHyIO o6o iomKy rjlaaa y co6ai, Ha6JIIO-
AaeMoro B CBH3H c ouepaTHBHMIM yyaJIeHHeM capKOMaTO3Hbix y3JIOB
HOJIOBBIX OpraHOB.
P e Ij H A H B M IIOCJTe ouepaTHBHoro yAaJIewaa H K a x e K c H H,
IIporpeccgpyIOma$I IIpH HaimmH ouyxoJrH y 6oilbHoro }KHBOTHOrO,
c 6oJI6mOH BepO$ITHOCTbIO CBHAeTeJIBcTByIOT O ee 3JIOHageCTBeH-
HOCTH.
PeHTreHoAHarH0CTIIit a. IIepe1HCJleHHble OCo6eHHOCTH OIIy-
XOJIOH BO MHOrHX cjiygasx He AaiOT AOCTaTOgHMX OCHOBaHHH AJIFI IIo-
CTaHOBKH AHarHOaa. HoJIb3yHCb HMH, He BcerAa yAaeTCH COCTaBHTb
OIIpeyeJIeHHOe MHeHHe o JIOKa3IH3aAHH oIIyxOJIH, o6 OTHOmeHHH ee
K CMe EHUTM opraHaM, K KOCTHM, o pailHOHa7iLHOCTH TOro HJIH HHOTO
AOCTyIIa c gern io oIIepaTHBHOrO y)aJIeHHH, HaKOHel; o6 ouepa6HJIb-
HOCTH. B BTOH o6JIaCTH IIaTOJIOrHH OT peBTresorpacpHH, a y McJIKHX
}KHBOTHbIX H OT peHTreRocHonHH MO}KHO IIOJIygHTb uCgepn MBaiO11 e
AaHHuIe, II03BOJIHIOIIXHO AeJIaTb OKOHgaTeJlbHble Bb1BOAb1 He TOJIBRO
o xapaKTepe ouyxoJiH, HO HHorLa TaHH{e o pa3pacTaHHH ee B Oupe-
AeJIeHHOM HanpaBJIeHHH, o CTeIIeHH pa3pymeHIIH KOCTeII (pile. 135)
H T. H.
3 H A 0 C K O H II H. Oco6eHHocTH ouyxonleH B o6JIaCTH meiHH MaTKH,
B upsMOH KHIIIKe, B MOgeBOM IIy3BIpe, rJIOTKe, uiII(eBOAe JTerHO
yCTaHaBJIHBaIOTCH IIpH 3HAOCKOIIHH aTHX opraHOB. OIIyxOJIH HOCOBOH
IIOJIOCTH IIpH AJIHT@JIbHOM H 3Ha1qHTeJT6HOM pa3paCTaHHH COIIpOBO-
u alOTCH Hpuo Bblpa}KeHHbNMH H3MeHeHHHMH 4)OpMM JIHI[eBoro gepeua
(puc. 136). HOMHMO HHX, pyre CLMIITOMbl, Ba}KHble AJIH AHarHO3a,
OTCyTCTByIOT. TOJILKO 3HAOCKOIIHH AaeT B03MOMHOCTB oupeAeJIHTb
xapaKTep Taxoro HoBOO6paaoBaHHH.-
B H 0 II C HR. AOCTOBepHMTH AHarHO3 oUyXOJIH o6e0IIegHBaeT rHCTO-
JiorHgecuoe HccJIeAoBaHHe xycogxa ee, HccegeHHOro Ha AoCTaTO !HylO
ray6HHy. He cJleAyeT IIpHCTyUaTb K 6HOIICHH, eCJIH He IIpeAHOJia-
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
raeTCH TYT me IIPHCTyIIHTb H onepaTHBHOMy yuaneHHio oIIyxoJIH.
HCCe ieHHe xycoin a ee, HaH H MHorne JjpyrHe pa3gpa}HeHHFi (Mexa-
PHc. 136. CapxoMa HOCOBOg HOJIOCTH.
HHgeCHOe, TeuJIOBoe, xHMHLiecEoe), cTHMyJIHpyeT OCT p6JIaCTOMbI
H IIpH 3JioHageCTBeHHESx onyxo ix ycxopseT ri6eJib 6oJibaoro
H{HBOTHOro.
IIporao3 IIpH 8JioxagecTBexxbix onyxoJIHx
KJIHHHgeCHH B 3 JI o H a g e C T B e H H 0 M P 0 C T 0 BHIgeJIfiIOT
TPH nepHoga.
H e p B I,i ii n e p H 0 A - OCT pB IIepBHmHOM oqare. Horga
TOT ogar AOCTyneH AJIH onepaTHBHoro yAaJieHHH, HMelOTCH Bee
OcaoBaHHH pace lHTmIBaTm Ha H3JIOgeHHe.
B T O P O E H e p H 0 A - poCT OIIyxOJIH C McTaCTa3oM B 6JIH-
Hfakmaii perHOHaJibHblg JIHMtJaTHgecHHi y3eJi. 3Aecb MO?HHO npe--
BHJ;eTh 6JiaronpHHTHb1I3 HCxoA, eCJUH HepBH*iablI3 oar H McTaCTa3
MoryT 6UT16 ygaJieHbI B nporecce oJHOH onepagHH.
T p e T H B n e p H o A- onyxoaIeBbii3 POCT C McTaCTa3aMH Bo
MHOrHx opraHax (reaepaJiH3aL HH). TaRHe cJiygaH He noRJieHCaT
OIIepaTHBHOMy BMemaTeJIbCTBy; rH6eJib MHBOTHOPO MOHfHO O EHgaTb
B HegaJieHOM BpeMelH.
OCHOBH16IM McTOAOM TepanHH IIPH OnyxOJlJx HBJIHeTCH y)aneHHe
Hx onepaTHBHhIM nyTeM.
A06poHa,geCTBeHHble OIIyXOJIH B nepH epHLiecHHx OTJjeJIax TeJia,
game Me)JieHHO paCTymHe, Ho conponom aIOI caeca 4 ynlfI[HOHaJib-
HbIMH HapymeHHHMH, Tpe6yIOT cpotHOro BMemaTeabCTBa (pHe. 137).
HeHOTopMe H3 HHx, HanpHMep nauuJIJioMM, HepeRHO Hcge3aIOT
CIIOHTaHHo.
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 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
 Sanitized Copy Approved for Release 2010/05/20: CIA-RDP80T00246AO43800010001-4
Be3OTJIaraTeJuHO nogaexcaT yAaneHHio 6ucTpo paCTyII He A06pO-
KavecTBeHHbte OIIyXOJIH, B TOM nHCJIe H nanHJIJIOMbi, HMeBBRsO CKJIOH-
HOCTb IIpeBpaIIkaTbCR B 3JIOKaiecTBeHHble, a TaJ)Ke OIIyXOJIH, Hapy-
MaioIIsHe H OXOAHMOCTb Tpy6eaTbtx opraHoB, C asnHBalomme Hepsabte
CTBOJIbi, KpyIIHNe COCyyW, BbIBbZBaIOIIwe IIOBTOpHbte R OBOT0*IOHHH
H ApyrHe ocao)KHeHHH. OTAenHIomne paapeam H oTIIpenapKposaHHe
TaIHx onyxoneH IIpOH3BOART HBIIOCpeACTB@HHO
Ha rpaHHAe c oxpyHialOMHMH TKaHSIMH.
a 3JIOKa'IeCTBeHHJIe OIIyXOJIH BO BCe% CJIytiaax
yAanaJOT B nopHAKe HeOTJIOH{Horo BMeMaTeab-
CTBa, ecim calla onepagaR He IIpeAIIOJIa-
raeT OCJIO)KHBHHE, yrpoHCaIoUUIx )KH3HH )KH-
BOTHOrO. Bo BTOpOM nepHOAe aHoRavecTBeH-
Horo pocTa panHOHanbaa.cuepsa yAajmTb
perHOHaabHEIH McTaCTaa, a 8aTTM HCCeiIb nep-
BHilHbtg o'iar PaspesM H oTAeJieHne TylbmM
PHc. 137. DH6poMa,
orpasH9MBawmaa no-
ABHHfHOCTb CyCTaBa.
MNIMH BKCIIO3HI;HRMH AO3 He6OnLmo i HHTOHCHBHOCTH, BO MHOrEx
c iy-iaRx yAaeTCR IIpeAOTBpaTHTb pet;HAHBbt 8a60JIeB'HHR. -
Ha 'wc is CHHTeTHLIeCHHx rOpMOHaabHMx IIpenapaTOB IIpHMe-
HRIOT TeCTOCTOPOH H CHHecrpoJl. McTOAs a HCIIOHb3OBaHH8 Hx,
6e8 IIepepIJBOB B Te'eHHe AJIHT0JIhHOrO BpeMeBH, COHpOBO)EAaeTCR
HexposoM IIapeaxHMbl onyxoJlefi, paapacTauHeM H py6ResaHHeM
COOAHHHTeJIbHOH TKam!, HMIIperHaIxHBH ee CoJiJMH.
naJIJIHaTHBHMe BMefaTOJibCTBa IIPH OIIYXOJIRX B AooIIepaTIHOH-
HbiH IIepHOA HanpaBJIeHbt Ha IIPOTHBOAeHCTBH0 MHKp06aM (eyab4 a-
HHaaMHAbI, aHTH6HOTHKH, HOAO~OPM H AP.), OCTaHOBKY KPOBOTe-
SeHHR (IIpH)KHraiomHe BenlecTBa), IIOAAep)KaHHe CHn 60abHOPo
)HHBOTHOrO (IIOBTOpHbte BBeAeHHR raioRoabt), Ha ocma6aeHHe 6onea-
AeHHOCTH (HOBOKaiH:, Mop(HH).
CIIOCO6oM nPOH3BOAHT B npeAenax saBeAOMO
BAOPOBIIIX TKaHeH, rAe OTCYTCTBYIOT KaKHe-
aH6o HPH3HaHH HH4)HJI16TpaTHBnoro pOCTa. B
xoAe onepa99H Ha6eraIOT paceeleHRR onyxo-
JIeBbIa yaaOB; 9THM HMB!OT B BHAy Ha6excam
HMIIJIaHTaAHOHHbix McTaCTaaoB.
B COBpeMeHHOg McAHI;HHOKOH IIpaKTHxe x
orpaHHeeHHHO B BeTepHHHapHoa xH.pyprHH noJIB-
ayIOTCR peHTreHO- H paAHOTepanaefi. KJIencH
3aOKa'IeCTBeHHbtx oiiyxoJIek O'JOHb tIyBCTBH-
TeJH Hbi K BO3AegCTBHIO JIy1IHCTOI aaeprmf.
3THM MBTOAOM, HORLByHCb LIaCTO IIOBTOPRe-
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B BeAeHHe . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
IIpeAMeT o6uieii xHpyprHH . . . . . . . . . . . . . . . . . . . . . . . .
CBHas x xpyprHH c APyrHMH AgcIjHIIJIHHaMH . . . . . . . . . . . . . . .
HyTH paaBHTHH COUTCHOs BeTepHHapHOS xHpyprHH . . . . . . . . .
OpraHHaar ioHHbie OCHOBLI npo( HnaKTHHH TpaBMaTHaMa H ero ocno)I HeHHE
y 7HHBOTHbIX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
HopcAoK Haalo f eHHa MaTepHana . . . . . . . . . . . . . . . . . . . . .
F4aea I. HposoTegeHue . . . . . . . . . . . . . . . . . . . . . . . .
OcTpoe MaJloxpoBT e . . . . . . . . . . . . . . . . . . . . . . . . . . . .
CaMOOCTalOBKa KpoBOTe*ieHHH . . . . . . . . . . . . . . . . . . . . . . .
HJIaccj KaJ Ma xposoTe9elHfl . . . . . . . . . . . . . . . . . . . . . .
CHJIa H npOAOJIMHTenbHOCTb KpOBOTegeHHa . . . . . . . . . . . . . . .
OCTaHOBKa HpOBOTegeHHH . . . . . . . . . . . . . . . . . . . . . . . . .
BpeMeHHan (npoBHaopHaB) ocTanosxa KpOBOTegeHHn . . . . . . . . .
OKOHgaTenbnag ocTaHOBKa KpoBOTegeRHH . . . . . . . . . . . . . . .
OH3HgecKHe CII0006LI OCTanoaRH KpoBOTegeHHR . . . . . . . . . . . .
reMOCTaTngeCKHe epeACTBa H Cnoco6hl Hx upHMeHeHHH . . . . . . . .
CpeAcTBa, CYMHBaIOnjHe cocyAhl . . . . . . . . . . . . . . . . . . .
CpeACTBa, uoaaIIIIaioir ue caepmmIBaeMOCTm HPOBH . . . . . . . . . .
Mephl 6opb6bl c KpoBOHOTepeH . . . . . . . . . . . . . . . . . . . . .
IIepeJIHBaune KpoBH . . . . . . . . . . . . . . . . . . . . . . . . .
OnpeJjeJleHHe coBMeCTHMOOTH xpoBH . . . . . . . . . . . . . . . .
AOHOp, ero coJ7,ep3KaHHe H HCnOJIbaOBaHHe . . . . . . . . . . . .
Cnoco6bl nepeJiuBaHHFI KpoBH . . . . . . . . . . . . . . . . . . .
MexaHHaM AeHCTBHg nepeJrHTOH xpoBH . . . . . . . . . . . . . .
OcjiomHeHHa, CBaaaHHhle c IlepeJifBaaneM xpoBH . . . . . . . . .
F.4aea II. Pami . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
HJIaccH( 1HKaI;na paH . . . . . . . . . . . . . . . . . . . . . . . . . . .
3a HBJIeHHe paH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3axcHBJIeHHe nepBHgaIIM HaTHHienneM . . . . . . . . . . . . . . . . .
3aMHBJIeane BTOpHIIHhIM HaT}H{eHHeM . . . . . . . . . . . . . . . . .
rpaHynaljnoHnaa TKaHb . . . . . . . . . . . . . . . . . . . . . . .
Py6ljesanne . . . . . . . . . . . . . . . . . . . . . . . . . . .
3lHTeJIH3aAHa rpaayJlnpyloigel paHII . . . . . . . . . . . . . . . .
3amHBJlenne IIOA CTpyIIOM . . . . . . . . . . . . . . . . . . . . . .
3aMeJjneane npoijecca aaxcHBneHHn paH . . . . . . . . . . . . . . .
OcaoBhl TeparHH npu paneHHax .. . .. . . . . . . . . . . . . . . . .
I4ccJIeAonaHue paHeHoro HCHBOTHOro . . . . . . . . . . . . . . . . .
ILHTonorugecxoe HccneAonaHHe paneBoro oTAenaeMoro . . . . . . . .
3Ha*ieane IIouoi upn paHeHHHx . . . . . . . . . . . . . . . . . . .
Ilpo~unauTHKa paaenoH Hii~enijHH . . . . . . . . . . . . . . . . . .
TegeHHe Hpoijecca npH aceuTWIHIIx paueasax . . . . . . . . . . .
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OnepaTHBHMe BMemaTeJn cTBa npn aarpHaHeUHH pan H paaeBog nH(kex-
ItnH ................... ........... 72
HoriHoe necegeane TpaBMHpoBaHHMx TxaaeH ......... .. 75
LIacTEgaoe Hccegeaae TpaBMHpoBaHHxx TxaHeR . . . . . . . . . 76
BTOpa'man xapyprngecxan o6pa6oTxa pan ..... ........ 79
BTOpHgmJie HIM ....................... 80
BcnoMoraTenanaie cnoco6x TepaunH npH paaenmix ....... 83
11pHMeaeane 7lexapCTBeHHSix BeIi ecTB B nepaoj( paaBHTHH rHOHHOH
paHeBOH HH4-exwan ? 84
IIpHMeaeane JiexapcTBeHHbix Bew(ecTB B nepnojt rpaayJlapoaaHHi
paneBxx noBepxaocTeH . . . . . . . . . . . . . . . . . 86
npHMenenne Jiei apcTBeHHaix BeIgeCTB B nepnoj( annTenHaaI HH . . ' . 88
McTOjtM CTnMyJIHAHH npH aamHBneHHH pan . . . . . . . . . . . 89
l.# aea III. 3axplaimie TpaBMaTHgecxae nonpenc enHH ....... . . 91
Ymn6 .................................. 91
Ymn6ai Mr n . .... .... .. ..... . ........... 93
YmH6x HepBOB . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94
YmH6ii xocTel ..... . .... ......... .. .. ....... 94
Ymn6M cycTaBOB ... ...... ... ....... . ....... 95
?PacTHmeaae H paapais ...... . .. ..... . ..... . .. 97
PacTHxceaae cyxo l nJlnH . . . . . . . . . . . . . . . . . . . . . . 97
PaapaBM cyxomanm i . . . . . . . . . . . . . . . . . . . . . . . 98
PaapMBM Mxallt . . . . .... . . . . . . . . . . . . . . . . . . .. . . 100
PaapaIBM ~ acltxi ..... ...... .. 101
PacTHxceaHe CyCT9BOS . . . . . . . . . 101
IIojtxosxaxe paapai a xpOBeaocHMx cocyjtOB . . . . . . . . . . . . . 103
reMaToMa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
J1HM( IO8HCTpaBaaaT . . . . . . . . . . . . . . . . . . . . . . . . . . . 106
IIepeJloMa . xocTef . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
BaiBHx . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
TpaBMaTncecxng nepaocTHT . . . . . . . . . . . . . . . . . . . . . . . 132
3axpai xe noBpe,W eHHa gepena . . . . . . . . . . . . . . . . . . . . . 135
rAaea IV. Mon .................. .. .... .... . 139
CHMfTOMM s fiegenne moxa . . . . . . . . . . . . . . . . . . . . . . . . 140
lnaea V. TepMHgecxne n xHMngecnne nonpem eunn. 3JieRTpoTpaBMa. . 147
Omor .................................... 147
OTMOpoxceane ....... ... ..................... 150
XHMHgecxne o north ........................... 154
HoBpexijteHHH anenTpHgecnHM TOROM . . . . . . . . . . . . . . . . . . . 156
lnaea VI. raoHHaa xlpyprw ieonan HH(OIMHH . . . . . . . . . . . . . .
rnaBaesmHe Boa6yjtiTeJia rao$aoi Hn~ei nth . . . . . . . . . . . . . 158
3au nTHxe npacnoco6neHHJi opraanaMa . . . . . . . . . . . 159
maKTopx, cnoco6cTBylontne paasnTHlo xnpypragecxoi HH(lexgna . . . 161
3Hageane aBHTaMHHOaoB n jtHCCyHxitnH aHAoxpnnaoi CHCTeMa B Boannx- 164
aosennH nH4 exwm . . . . . . . . . . . . . . . . . . . . . . . . . 165
Pons HepBHOH CHCTeMM B paaBHTHH na exgHH . . . . . . . . . . . . 168
Peaxl;Ha opraaaaMa npH rnoinoi nn exltaH . . . . . . . . . . . . . 169
OcaoBM TepannH npn raogHxx npoi;eccax . . . . . . . . . . . . . . . 172
?ypyynsnyn .. ............ ...... . ... ...... 175
Hap6yaxyn 178
A6cltecc . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
mnernoaa .. ..... . . ... . . . . . . . . . . . .... 182
DJIe6HT H TpoM6o4Jze6HT . . . . . . . . . . . . . . . . . . . . . . . . 184
Bocuanenne JIHM(aTHgecxnx COC ) OB . . . . . . . . . . . . . . . . . 187
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JIHM~aAeHHT (JmMl osoAyJIwr) . . . . . . . . . . . . . . . . . . . . . . 191
CJIOHOBOCTb . . . . . . . . . . . . . . . 194
rHOaHOe BocuaneHHe KOCTea . . . . . . . . . . . . 199
rHogHr IIepnOCTHT . . . . . . . . . . . . 199
FHOAHOe BocnaJleHHe KOCTH . . . . . . . . 201
OeTeoMHaJuIT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
raaea VII. O6u aR raoihzan nH(peRAHn. Cenenc . . . . . . . . . . . . . 210
Haac=H HxaAHn . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210
raaea VIII. AHaapo6Han H ro&IIOCTaa, HHIexAHA . . . . . . . . . . . 217
AHaapo6Haa Hn eRAHH . . . . . . . . . . . . . . . . . . . 217
Boa6yAHTenH . . . . . . . . . 217
YcnoBHH, CHOCO6CTByIOH[He pa3BHTmo aaaapo6oB B Txaaxx . . . . . . . 218
HnaccHCHxaAan . . . . . . . . . . . . . . . 220
rHHJIOCTHaa (nyTpHAHag) HH(ernHH . . . . . . . . . . . . . . . . . . . 225
raaea IX. CHeAHI4agecxge HHI IexAHH . . . . . . . . . . . . . . . . . . . 230
ARTHHOMHxoa . . . . . . . . . . . . . . . . . . . . . . . . . . . . 230
BoTpaoMHxoa . . . . . . . . 237
CTpeIITOTpHx03 (IICeBAOauTHHOMHH03) . . . . . . . . . . . . 240
Bpyiennea . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
raaea X. OMepTHeaae . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
HnaccH iuxarHa . . . . . . . . . . . . . . . . . . . . . . . . . . . 246
TegeHHe . . . . . . . . . . . . . . . . . . . . . . . 246
TpaBMaTHgecuHH Hexpoa . . . . . . . . . . . . . . . . . . . . . . . . . 247
OMepTBeHHe IIpH 8M6WJIBH H TpoM603e . . . . . . . . . . . . . . . . . . 249
OMepTBeHHe npH ToxcHgecuux aa6ojleaaHHRx . . . . . . . . . . . . . 249
OMepTBeHHe npH HHCJerAHOHHSIx 3a6oJIeBauHHx . . . . . . . . . . . . 250
CHMMeTpHgaaH raarpeHa xone'HOCTes . . . . . . . . . . . . . . . . . 250
HoMa ................................... 254
flaBLi ................................... 255
CBHIAH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
raaea XI. HHOpoAmIe Terra . . . . . . . . . . . . . . . . . . . . . . . 262
PaccacbiBaHHe HHOpOAHLIX Ten . . . . . . . . . . . . . . . . . . . . . . 262
HHHancynnAHR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 262
HHCexAHR npH HHOpoAHbix Tenax . . . . . . . . . . . . . . . . . . . . 263
HHOpoAHLIe Terra IIHIAeBapuTenbuoro TpawTa . . . . . . . . . . . . . . 264
HHOpoAHbie Terra APyrHx opraHOB . . . . . . . . . . . . . . . . . . . . 266
IIepeMen;eHHe HHOpoAHMMX Ten B TxaHHx . . . . . . . . . . . . . . . . 266
IIoxaaaHHA x yAaneHHio HHOpoAHrIx Ten . . . . . . . . . . . . . . . . 267
raaea XII. MHOaHmI. MHOHaTOaba. TeoAHHHTbi . . . . . . . . . . . . . 268
Fuo aaig MHOBHT . . . . . . . . . . . . . . . . . . . . . . . . . . . 268
PeBMaTHgecIW MH03HT . . . . . . . . . . . . . . . . . . . . . . . . . . 270
MHonaTOaM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273
IIpOCTOH xoopAHHaTOpHLIH MHonaTO3 . . . . . . . . . . . . . . . . 273
D acIHxynxpHhI ROOpAHHaTOpaaIS MROnaTO3 . . . . . . . . . . . . . 274
MHOIacrHxynHT . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
TeHAHHHT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276
OcTplaa aceIITHgecuHH TeHAHHHT . . . . . . . . . . . . . . . . . . . 276
XpoHHgecHHH aCeuTHgeCHHH TeHAHHHT . . . . . . . . . . . . . . . . 277
rHOaabla TeHAHHHT . . . . . . . . . . . . . . . . . . . . . . . . . . 279
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F.4aea XIII. BoenaneHae cm aKeTWX, o~osaaabmuc oyMOO s eyaOU?nb-
Bn" snaraamg 281
BocnaaeHHe CnBaxeTM? cyMox ..... ............... 281
AHaTOMaeecRHe Aanuue . . . . . . . . . . . . . . . . . . . . . 281
Bocnanenxe cHHoBHaJIHMx cyMox m cyxoHCHnmHMx BnaramEm . . . . . 292
AHaTOMHiqeciHe Aaaaie .. . . . . . . . . . . . . . . . . . . . . . . 292
r aea XIV. ApTpImi .. .. ........ .. .... .. .. 302
AHaTOMo4Hanonorzeec1He AaHHMe ......... ... ...... 302
HnaccB nxaIHa ngpaHieHHS C CTaBOB .... ... .... ... 305
ACenTH4ecxHe eRCC3ABTHBHM8 BOCnaneHHH CyCTaBOB (aCeuTHYBcxHe
CHHOBHTLI) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 306
PaseHHS cycTasoB . . . . . . . . . . . . . . . . . . . . . . . . . . . 310
FHOaHOe BocnaneHHe cyCTaBOB . . . . . . . . . . . .. . . . . 314
XpoassecRHe 6eq9xccyAaTHBHLIe npoAeccu B CyCTaBdX 324
XpoHHeecxna occH~XIXJIpyJDUWi nepnapTpsr ...... .... 324
ApTpoa, OCTeoaprpHT A e0opmapyugut apTpwr ..... 327
PeBMaTHSecxoe Bocn40enHe cycTasoB. CycTaBHOt peBMaTHBM . . . . . 334
raaea XV. IIopaacemui uepBHbg eTBOIIOB .......... ....... 336
AHHaMHxa Mop onorBsecK= HaMeHOHH8 ...... . ... .... 336
HJIHHH,qecxHe npKBHaxl{ . . . . . . . . . . . . . . . . . . . . . . . . . . 340
Bocnarieane HepBOB . : . . . . . . . . . . . . . . . . . . . . . . . . . . 341
F.saea XVI. OHxoi epxda . . . . . . . . . . . . . . . . . . . . . . . . . 343
HaToreHea ... ............. 343
rlaTOnoroaHBTOMHcecIHe H8MOHeHHH . 345
Ocao uHeHHe oaxoiepxgasoro npoiecea upH HH#AHposaHHH ...... 348
CHMIITOMM H aarHOCnka .. . . . . . . . . . . . . . . . . . . . . 349
Ewa XVII. OnyxoaH, noBoo6paaoBamn ..... .. .. ...... . 352
3THOaorHH H naToreaea . . . . . . . . . . . . . 354
RR#epeHI(HanbHag AHarnocTHKa . . . . . . . . 356
Hpornoa npH anoxaeecTBeHHUx onyxonax . ....... ... . .. .. 362
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Heau Emeneanocun Hocaicenno.
061gaa BeTepnnapnan xnpyprxn.
PepaHTop A. C. Conoeea.
XyAOntauH H. C. X.MeneacxaA.
XypoxiecTneHHblil pepaHTOp H. M. Xoxpuxa.
Texan=lecJHN peAaHTOp H. H. Coxonoea
HoppeHTOp E. H. F1nnoec+ca..
CAano n aa6op 24/V 1956 r. IIopnncano 8 ne'IaTI
7/VIII 1956 r. T-07272. ByMara 84X1081/32.
IIeq. n. 23 + 5 min. YT.-n3A. n. 24,08.
Tnpanc 15 000 aHa. 3a8a3 N 1276. Ileaa 7 p. 90 H.
Cenbxoarna, MocHna, B-66, 1-11 EacMaxmi#
nep., A. 3.
MIIHCTepCTUO HynbTypbl CCCP. PJlannoe ynpa3-
nenne nonnrpa$n'lecxoi upoMb[mneHHOCTH.2-n
TMnorpacpan .IIe'IaTHbl1i Z[uopc> MM. A. M. ropb-
Horo. JIeHHHrpaA, raTgHHdHan, 26.
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STAT
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