NEW USSR WORK ON THE PHYSIOLOGY OF VASCULAR REFLEXES

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700240158-9
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 3
• Document Creation Date: December 22, 2016
• Document Release Date: July 11, 2011
• Sequence Number: 158
• Publication Date: December 15, 1955
• Content Type: REPORT

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NEW USSR WORK ON THE PHYSIOLOGY OF VASCULAR REFLEXES
(Comment: This is an abstract of an article by R.A. Dymshits
published under the title "Concerning the Problem of the Physi-
ology of Vascular Reflexes" in Fiziologichniy Zhurnal, Vol 1, No 4,
Kiev, Jul-Aug 1955, PP 70-74, as a contribution from the Chair of
Pathological Physiology, Chelyabinsk Medical Institute.
Numbers in parentheses refer to the author's bibliographyy
appended.)
G.P. Konradi (1, 2) and A.G. Bukhtlyarov (3) established that injection
of a 20% solution of sodium chloride produces a different reaction depending
on whether the solution has been injected intro-arterially or intravenously.
Intra-arterial injection produces a pressor effect while intravenous injec-
tion exerts a depressor effect on the vascular system. G.Y. Popov later found
in work carried on at the laboratory of the Chair of Pathological Physiology,
Chelyabinsk Medical Institute, that intra-arterial 'injection of a solution of
sodium chloride of this strength weakens the tonus of the small intestine of
dogs and inhibits peristalsis while intravenous injection increases the tonus
and strengthens the peristalsis (4).
On the basis of these results the conclusion was made that intra-arterial
introduction of irritants produces a reflex excitation of the sympathetic
division of the vegetative nervous system while intravenous introduction
produces an excitation of the parasympathetic division. To check this conclu-
sion, an investigation of the sympathomimetic and cholinergic properties of
the blood was carried out after antra-arterial and intravenous injections of a
20% sodium chloride solution.
The experiments were carried out on adult dogs which had not been fed.
Eight dogs were used for the investigation of the sympathomimetic properties
of the blood and seven dogs for the investigation of the cholinergic properties.
The blood and blood serum taken from the dogs prior to the experiments
were found to accelerate and strengthen the contractions of a frog's heart.
After intro-arterial injection of a 20 salt solution both the blood and
blood serum exerted a stronger stimulating effect on the contractions of a
frog's heart than before the injection.
Tests carried out with blood taken after intravenous administration of
the salt solution showed that the isotropic and chronotropic effects exerted
by this blood on the isolated heart of the frog are less pronounced than those
produced by the blood after irritation of the arterial receptors.
The results of the investigations which have been carried out in this
instance indicate that under the effect of the irritation produced by the
salt, substances which are very active with respect to a frog's heart appear
in the blood of dogs. These substances are apparently of a sympathomimetic
type. They appear as a result of a stimulation of the sympathetic division of
the vegetative nervous system.
Tests carried out on the eserinized dorsal muscle of leeches have shown
that after intravenous administration of a 20% sodium chloride solution a
considerable increase takes place in the acetylcholine content of the blood
of dogs. Under the effect of the blood taken from dogs after intravenous injec-
tion of the salt solution the contraction of the leech muscle increased greatly,
which testifies to an increased content of acetylcholine in the blood as com-
pared with the content of this substance before the injection.
STAT
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It should be noted that no increase in the acetylcholine level was observed
after administration of a 20% sodium chloride solution into the Femoral artery
of dogs.
We may thus conclude that after introduction into the arterial blood flow
(countercurrently) of a 20% sodium chloride solution neurohumoral changes of a
sympathergic character arise. On the other hand, intravenous introduction of
the same solution produces predominantly cholinergic reactions in the body.
1. G. P. Konradi, "The Role of Vascular and Axon Reflexes in the Regulation
of Arterial Blood Pressure," Trudy Voyenno-Meditsinskoy Akademii (Works
of the Military Medical Academy), [No] 4, [p] 1, 1944
2. G. P. Konradi, "The Peripheral Mechanism for the Maintenance Of the
Vascular Tonus," Trudy Yubileynoy Nauchnoy Sessii Kirgizskogo Medinstituta
(Works of the Jubilee Scientific Session of the Kirghiz Medical Institute),
1944.
3. A. G.Bukhtiyarov, 0 Vnutrivennom i Vnutriarterial'nom Vvedenii Nekoktorykh
Khimicheskinh rtazdrazhiteley (Concerning the Intravenous and Intra-Arterial
Introduction of Some Chemical Irritants), Naval Medical Academy [Leningrad],
1949
4. G. P. Popov, "The Reflex Reactions of the Small-Intestine of Dogs to the
Irritation of Vascular Receptors," Fiziologichniy Zhurnal Vol 1, No 4,
pp 75-79, Jul-Aug 1955
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