REDUCTION OF THE HARMFUL EFFECT OF X-RAYS ON THE SKIN OF RABBITS WHEN IRRADIATION IS CARRIED OUT THROUH A LEAD LATTICE

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600380609-4
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: September 9, 2011
• Sequence Number: 609
• Publication Date: March 30, 1951
• Content Type: REPORT

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INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS CD NO.
CLASSIFICATION CONFIDENTIAL?E"t
CENTRAL INTELLIGENCE AGENCY REPORT
COUNTRY USSR
SUBJECT Scientific - Medicine. radiology
HOW
PUBLISHED Thrice-monthly periodical
WHERE
PUBLISHED Moscow/Leningrad
DATE 21 Nev 1950
PUBLISHED
LANGUAGE
DATE OF
INFORMATION 1950
DATE DIST. 30 Mar 1951
SUPPLEMENT TO
REPORT NO.
THIS DOCUMENT CONTAINS INFORMATION AFFECTING THE NATIONAL DEFENSE
OF " MAGE ACT
U. THE UNITED SAS WITHIN
SM AND 3ET AO AMENDED. 11 ITS TRANSMISSION OR ITHE OVA ELATION
OF by TLAWS I REPRODUCTION OF THIS FORT. OISI FROHISIITED IS IRO
THIS IS UNEVALUATED INFORMATION
Dokiady Akademll Nwuk SSSF, Vol L. LV, No 3, pp 60--W;8-
REDUCTION OF THE HARMFUL EFFECT OF X-FAYS OH TITS G%.:LN OF RABBITS
WHE.T~ IRRADIATION IS GAF1i. O? THFO:C'H AiLEAD IA??ICE
r. S.. 8trelin, V. X. Shmidt, Y.u, C., Z'_1'bergy
Cen !~,..^e tRe C1Gai 0.31, Radiological,
and^-anger Ir..st, Min. of Pub Health USSR
~,U?`t2' t ed 21 Jul 1950
r--~en.ed by A~e.d N W r--r,kc,v, 27 Sep 1050
In roentgenological investigatlene rg.rried cut or. various tent objects
including hydra (,1), turbellarie !,Planaxia) (2, the wont F.ir.cbeiInt (3;, and
principally the axolotl (4, 5, 6, 7, 8), it vas found t at? the irradiated part
of the organism which bas loaf the capacity for regene.cat'G_ reccver that
capacity after growing together ur being transplanted in such a manner that a
close contact with nonirradiated, healthy tissue is established. These ot-
servations are in agreement with still rat-hex meager data in the medical
literature to the effect that erythema of the human skin i.e produced at higher
doses of X-ray radiation when the skin is protected by a metal lattice (9, 10).
Interaction between the nonirradiated and irradiated tissue apparently also
exerts an influence here, as it does in the experiments mentioned above. An
investigation of this effect would contribute to a'knowledge of the mechanism
involved in the action of short-wave radiation of biological objects as well
as clarify the nature of the desensibilization of the skin achieved by the
use of a grating in connection with the X-ray treatment of malignant tumors (9).
In the present communication are reported the results of an investigation
carried out on rabbits by irradiating chemically depilated 25 eq cm skin patches
(in the region of the sacrum) directly on one aide of the body and through a
lead lattice on the other side and then comparing he injurious effects. The
irradiatinn was carried out under feeding to the X-ray tube of a current of 90
kv and 4 ma, The distance from the anticathode to the object was 23 cm and an
aluminum filter 1 mm thick was ueed,. Ninety roentgens per minute were applied,
The lattice consisted of lead strips O~5 mm thick and 3 mm wide with a spacing
of 4.5 mm between them. The 18ttice was covered with paraffin, so that it
stuck to the skin and did not move during the experiment, In all experiments
the irradiation was carried out continuously during a Dingle period,
CONFIDENTIAL
DISTRIBUTION
CONFIDENTIAL
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Sanitized Copy Approved for Release 2011/09/14: CIA-RDP80-00809A000600380609-4
 Sanitized Copy Approved for Release 2011/09/14: CIA-RDP80-00809A000600380609-4
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CONFIDENTIAL
The criteria used in comparing the extent of injury were development of
hyperemia of the skin, scaling, falling out of hair which grew after depilation,
and ulceration. We also evaluated the disappearance of these symptoms in the
course of regeneration. Our results show that interaction between nonirradiated
efishaapplied, ccon-
and irradiated sections of the skin, in cases whea lattice
siderably lovers the extent of injury caused by-irradiation
are reasons to assume that the reduction of the adverse reaction is brought
about by a more rapid regeneration of tissue rather than a weakened initial
irritation.
In another series of experiments we excised 4 eq cm of skin in the center
of the irradiated patch 10-15 days after the ;.rrad?ation, thus exposing the
-fascia, and then observed the process of healing of the resulting wounds. Our
results show that the rate of healing of wcu:_dc was much greater after irradi-
ation through a lattice than the rate observed upon raiation*,wiwithout
out ass
reached
lattice, although the amount of radiation energy which
the same in both cases. In four experiments a 3 to 4 times larger amount of
energy was supplied through the lattice than in experiments without a lattice.
Nevertheless, the wounds healed within approximately the same time in both
cases. This means that the suppression of restoraresult iapacityed fethelrrate
ate
of regeneration) was the same in toth ca..ee The
to the conclusion that with the use of a lattice one may considerably increase
the penetration of X-rays in depth by strengthening the dosis and still not
increase the amount of skin injury. Under ;~hetciruuestof a a it is
to develop methods of deep X-ray therapy
1. V. F. Yevlakhova, DAN SSSR. Vol LIII, No L, 1946.
2. N. N. Shevcheniso, By-all Eksp Siol i Had (Bulletin Fxpr_riment.al. Biology
and Medicine), Vol VI, No 3, 1938?
3. L. N. Zhinkin, Tr LEZM (Works of she Laboratory of Experimental Zoology
and Morphology), AN SSSR; Vol I:i, 19'4?
4. E. Ye. Umanskiy, Biol Zhurnal, Vol 71 , No 4, 193 937., No 4, 1948.
5. E. Ye. Umanskiy and Yu. A. Basina, DAN SSSR; 1 LX,
6. Ye. Pukhal'skaya, Byull Ekep Biol i Med, Vol .X, No 3, 1940.
7. L. D. Liozner, DAN SSSR, Vol LVII, No 6, 194?
8. V. F. Sidorova, DAN SSSR, Vol L.XV.III, No 5, 19'9..
9. A. A. Tseytlin, Acts. Medics, No 1, 1945.
10. T. Liberson, Radiology, Vol XX, No 3, 1933.
.CONFiUE flLAE
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