(SANITIZED)UNCLASSIFIED RUSSIAN-LANGUAGE PAPERS ON PHARMACOLOGICAL RESEARCH(SANITIZED)

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00247A002000030001-4
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 121
• Document Creation Date: December 23, 2016
• Document Release Date: November 26, 2013
• Sequence Number: 1
• Publication Date: December 3, 1964
• Content Type: REPORT

Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
50X1 -HUM
Next 41 Page(s) In Document Denied
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
113 omdena OU3U0,102UU Koponeecnoeo yHueepeumema e 2.1KHO YCTaHOBHTb 34)CIRKTHB-
HOCTb neKapcTB newrpanbHoro Adlowi. HO
OTH01.11e411110 BbI3BaHHbIX 110TeH1114a110B 3Ta
TeXHI4Ra OCHOBalla Ha TOM npeAnonoweHHH,
LITO nwrepcDepHpylowHe curHanbi pacnpe-
,RensnoTcH B CJIYIlar1H0M nope 14, 1103TOMY
apinpmemtiecKoe cymmHpoBaHme MH0r011HC-
J1eHHbIX OTBeTHbIX peaKinni npeoAoneBaeT
alcixpeKT BapHawn4 H HpHBOAHT K CTa6HJIbH011
(1)0pMe BOJIH 0'0JB:4:1111TO/1H, nI4K, reilanep,
Knanr, Canton, Bepnoy, 1959; Bpa3be,
1960; ronb,gurreilH, 1961). YcTaHOBJleHO,
11TO 3HaLIHTelIbHaR BapHainni B Bb1-
3BaHHbIX noTeHnHamax 11p0HCX0,1114T OT B3a14-
m0Tiet1cTBm51 C 3J1eKTp1411eCROCI aKTHBH0CTb10
(poHa (A6paxamc H naHrBopc, 1963) ; cneAo-
BaTe.TH3H07neKapcTBa, AdicTBytoulHe Ha 3JICK-
Tp1411eCKY10 aKTHBHOCTb (Dula 110BJIH1IOT,
npeAnono)KHTenbHo, H Ha BbI3BaHHbIe 110TeH-
1.1HalIbI npH 110J1b30Ba HHH meTuom vcpeA-
HeHHH BbI4HCJII4TenbHbIM annapaTom.
06cY>Kita1oTcH CJIeTICTBI45 BbIllIeH3J10)KeHHOTO
npH oneHKe gerICTBHR 6ap6HTypaToB, a Taloe
peineHme 3T0r0 Bonpoca.
18
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
2
113 Cmomamomzugeacou 1izuHueu U liticmumyma Oapniamo-
nozuu Meduuuttacoeo ynueepcumema e e. pe6petiett, Bettzpun
i4C11bITaHHe mecTnoanecTemippounix npe-
napaToB Ann 3y6oBpage6nort IlpaKTHKH
AJATIEP ti S. 1(E.TIEHTEH
Tax }cat( o6inenpHmemiemme H HacToHinee
Hpemsi mecTHoaHecTe3Hpylo11U4e cpeAcTsa 6e3
PICKJI101.1CHH51 ollOCTaT0t1H0 344eKTVIBHbl, OTHO-
CHTCJIbH0 rano Hpe,aHm JJI TKaHeii H npH
06bItIHbIX B cTomaTonorm4 Ao3ax cosepuieHHo
6e3onacHm (HeTOKCHLIHM) ? Aeno Ha npax-
THKe He B TOM, T066I H3YtlaTb, MONCHO JIM
C nomouncao mermoil gamy co,Rep>xaHHHOHO
aMIIY.TIbI o6ecneturrh 6e360JIC3HeHHOCTb,
jo-
CTaTO'lHYIO J15 Y,aaJICHHSI 3Y6a H AJ13 Hme-
maTenbcTsa B flYJlbflY, HJIH aHecTe3HpyeT
19
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
JI14 npHmenenHe nom-10r? coAepwatu4B
aM-
nYJTh! Taxwe npnneraroulne (14 cxo.nwo HX)
3Y6bI ; BaweH np14 nem 3Tom ripeNme Bcero
Bonpoc CB060AHM roToBble K BrIpbICK14-
Baffin? cmecm OT KOJITIa11COreHHMX no6otimp1x
AekTB1411.
1103TOMY Heo6x0,z4nmo 14317414Tb aHecTeBnpv-
iouve cpejcTsa He KaK TaKoBble, a PICIMITbI-
BaTb ToproBble aMilYJIbl B cimpmaKo.norwie-
CKOM OTHOLLIeHl4 H.
Mbi cpaBnHBann Asa pa cTsopa
pacTsopeHubix B 0i114HaKOBOM pacTBop14Tene,
3J1 Apyr OT Apyra TOJIbK0 no
OTHOIlleHH 10 np116awneHHoro COCY,a0CY>K14-
Balowero cpeAcTea, HOCKOJIbKY B 0,4H0111
pacTBope cop,epwa.noch 0,08 mr TapTpaTa
-HopaApeHasimila, B ApYrOM we ?0,04 mr.
TapTpaTa -HopaApeHam4Ha +0,015 mr aApe-
lianilHa. B OTHOWeHHH II00A0JDKI4TenbHOCTI4
344eKTa (npo6a Requier Ha poroKine Kpo-
.114Ka) 11 JerICTB1451 Ha xpoBBHoe AaBneHme
(Y 41apKOT14314p0BaliH011 XJ10OaJ1030r1 KOWKe
npn IICKYCCTBelillOM AbIXaM414), a TaloKe B OT-
HOWeH14 14 11,1150 AIM Kpo.m4Ka 14 Mbffilli (npm
noaxo>KHom BBeAetimll), coAepwainmri Hop-
aApenam4H 14 aApellas114H pacTsop oKa3anc54
6onee 6.1aronpi4BTHbim. B fu14HntlecKom 11C-
I1b1TaH1114 6e3ycneumocTb noc.ne BBe,letn451-
Hkrbetaw4 Ha6mAanacb name B CBE314 c pacT-
Bopom, coAepwaumm WI,H1 1 TOSIbK0 HopaApe-
HaJIMH, B TO BpemB KaK paccTpaicTBa KpOBO-
o6patueHI4 BcTpenannch name noj4BJIHHHIleM.
KOM6HHa111414 COCYJWCY>K14BaIOLI14X BealecTB
(HCIIOJIb30BaJI0Cb no 1400 aMilYJI 06011X
pacTBopoB). flpoTHB TaKoro po,aa HeTSI)KenbIK
paccTporicTe II03TOMY pexomeHAyeTcH ripHme-
Mtn HeCKOjIbK0 noBblu1eHHoe KOJI141-1eCTBO
aApeHaamHa.
20
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
3
113 lincmunlyma arccneptuuentnanbiloti 6uoaoeuu U 3tieOUULUM1
Muuucmepcmea 3dpa600xpanenuR PCOCP
BBHHHHe HeHOTOpb1X aeKapcmeHHIAX
cpeacTH Ha o6meHHme npoHeccm mmoaapaa
B Hopme H HaTOBOICHH
r. APXVIFIOBA
143Y Liefule 6HOXVIAIH4eCKHX OCHOB 4)1431(10J10F14-
TiecKort aKTMBHOCTVI Cep,11,e4H0r1 MbIWIAID1 weer
tipe3Bb11ailmylo Ba>KHOCTb, MK pacull4pBeT
BoBivto>iKAeHHH o6 o6meH-
MAX npoueccax B MHoKape HccneA0BanHcb
cne,avioulHe noKaBaTenH : B Kp0B14 neBoro
>KeJIYAOHKa 14 Hai 03H0F0 CI4HYCa onpe,geng-
ROCb a) coAepwaHme maxpo3prlltiecKux (poc-
cpopHbuc coeAHHeHmil ; 6 ) 3J1eKTpOJIHTbI
Na, Ca); 6) HacbnueHme KpOBH KHCJI0p0,140M ;
B mmoKape HccneAoHanoch TKaHeHoe Abaa-
HHe H coAep>KaHHe AT u A,11413. B 3KcnepH-
marre 14 KIIIIHHKe HUI 051b30BaJIHCb : a1eT1UI-
X0.11HH ? npH KopoHaporpaOH, ATep ripm
oc.na6ReHHH cepAetnial Ae1TenbHOCTI4 np14
nopomax cepjma.
B pa6oTe o6cy>K1a1oTc1 oco6eHHocTH Aeil-
CTB1451 cpapmaKonorHuecnix HpenapaTos Ha
o6meHHER npoHeccm B mHoKapAe B YCJI0BH53X
HOpMbI H naTonorm4.
22
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
4
113 IV mepaneenuviecuozo ornaeAenuu u Ilenmpa a /IR cepaegno-
cocyducmux 3a6o4e6arturt Baptuaacuozo meduquucuozo uucmu-
myma
OueHHa AeliCTBHH renapHHowlos Ha OCHOBe
6HOXHMHIleCHHX, HmmyHoanewrpocliopeTHqe-
CKHX H Tpom6o3nacrorpa4mgecam Hccae,ao-
BaHHil
3. ACKAHAC, 14. MA3YPIIAK, V. TEHEHSAYM,
3AMSPOSI4t1 a 3. MAJIAHKOB14,4
1/13ygeHHe itericTHH renapHHoHAoH B 1961/63
rog,ax 6bino Hanpas.neHo Ha AoKa3aHHe Toro
(DaKTa, qTO Y 60J1bHbIX aTepocKnepo3om 3TH
Bemecna CHHHCHIOT Yp013elib JIHTIOHAOB 14,
Kpome Toro, Ha HuHcHeHHe mexaHHama Tketi-
CTHHH renapHHowlos. 14ccneAoHaHHH 6b1J1I4
23
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
.:IA-RDP80-00247A002000030001-4
riposeAeHbi KK in vivo, Tax 14 in vitro, 1160
6bI.110 AoKa3aHo, 4TO ? B IlpOTHBOBOJIM-
HOCTI) renapHHY renapmHomAu 30eK-
T11BHbl Taxwe in vivo. B 011101Ta X Ha )404BOT-
MAX rpyrma neliefflibix renapitHomitamti xpba:
cpaHHHHa.nacb C Henegetwoil koirrpo.nbHoti
rpynnoil.
OCHOBH0r1344eKT renaprwoHAoH exa3b1BaeToi
B cneAytoutem : HoHit>xeutte YpOBBA o6inero
14 cHo6mHoro xonecTepHila, HoHIpiteinie
YpOBFIR 0611114X .111411014)1,0B 14 HopmanH3ain451
noxa3aTein1 Jlemepa, trro o61)1cH51eTcs1 C1114-
>KeHHem npolleHTa 6eTa-Ji4rionpoTeutioH B CU-
BopoTKe. Bonee no,apo611b1m4 Hcc.neAoHaHH-
AMM 11011 13.1114.21-11401 renapHHoH,u,oH 6bino 06-
HapyweHo rionbmietuie YpOBH54 CB060A111)1X
>K14p11bIX KHCJIOT 14 1101114)KCHI4e noxa3aTe.r51
BCaCblBaH1451 171o,Ra. 14mmyHo3nexTpocliopeTH-
IleCK14M14 14C1-1b1TallHAIVIPI 6131110 YC-PaHOBJleHO,
4TO 110j1 ,aerICTBI4eM reriapHHowkoH aHTHren-
Huh' cocTas 143Y4e1-11-1b1X Cb1B0pOTOK He 143-
nteu51eTc54 14 ? 3a HclunolieHmem iiHnoripo-
Te141-10BbIX cppaiatriti, mmrpmpylomx 6b1CTpee
B anexTmiecxom Hone ? .414H1414 ripe41rnH-
'mu4H He 143Me1iBIOTCR. Tpom6o3nacTorpaci14-
iiecxHe 14C1113ITa HilSi o6HapY>1a4r114 HexoTopyto
TeHitemitHo 1< Hopma.rmantut cHaliana 1401114-
WeHHOIA (1)146pHHosarrittiecxoti aKTHBHOCTI1
BOA BJ114531-11401 nimmeuslembix nexapcTB. Ha
0CH0BaH1414 nponeemibrx 011131TOB Hpe,ariona-
raerol, 11TO AerICTBI4e renapHHomitos 3a8HCHT
OT aKTI4B143a111414 J11411a3H0r0 j4eileTB14f1 -
rionpoTemHoB.
24
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
5
143 20p0oCHOCI 1101111K.6111114KLI 6 Z. AL)lie, Bat2p1.1.6
KoringecTnennbie H Kavecneennue pacxow-
Ae1114,1 no Ae1CTBH10 HeKOTOpbIX nespodtap-
maKonorwieciinx cpe,acTs npn HePBHMX Ba-
tioriesaminx oprann3ma B cramin pamorrun
W. Bj1A)-K0
1/1.3Y11aJIBCb ,TI,OrICTB14.54 Hex?Topmx neKapcTH
(xnopnpoma3H. MHAoKanm, pe3eptu4H, l-rmo-
TamsmoBaH KI4C.110Ta), yriorrpe6s111embix npH
conposo-,-Kg,alouwx paccTpoiicToa moropHoro
CTpOeHlig 3a6o.leHan145tx ; HpHmeHHInicb
JO3b1, ewe He Bbl3b1BaIOLLII4e T1060t1HbIX
B 3aBI4CI4M0CTII OT INIOCTOHaX0)K,ReHH54
pa 311101HbIX HaHraTenbubix pa CCTp0ACTB 06-
Hwrepecnbie KOJI1411eCTBOHHble
14 KaHec-roeymbie OTKJIOlieH1454.
Knopripoma3nn HaiV11-10F0 nyHwe nepeHocHTcH
i50J1bHbIN114 11p14 AsviraTenbHbix paccTpoil-
CTBaX, Bp014CX0A51111,14X OT nopa>KeHHH KOpbI
6011bWOTO mo3ra, Hem B cnyttae Hopa>KeHHH
M03),KeLIKOBOrl 145II4 3HcTpan4pammp,H0il C14-
CTOMbl. B cBsi3alinux c 31(c-rpanHpamiumbim
nopaweHHem cnyHagx HeRHHHHa ABIATeRbH0
HpHmeHmmoil j1,03b1 ormeHaeTcH He coHn1-
BOCTb10, a Hao6opoT, HacrynneHHem SisneHmil
B036Y>KAe141451, B IlaCTHOCTII, lace YCHJIHBa10-
werocH Jp0>Ka111451 14 iVIOTOpH0r0 6ecno-
HO cTsa.
25
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
:IA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
IA-RDP80-00247A002000030001-4
B c.nytme npeo6.naAaHHH m03>KetwoBoro no-
paweHHH MHAoKanm nepeHourrcH nopa3H-
TenbHo xoporno. ECJIH 3Ke Ha nepHom n.naHe
IlpH3HaKOB CTOHT Hopa>KeHHe afccTpanHpa-
MHAHOri CHCTeMbI, TO MHAOKaJIM nepeHocHTcH
3HatlI4TeJlbH0 xywe. Flpellenufam Bemituma
xpoHmecKo HpHmeHHmoti jowl oTmetmeTcH
ripH ABIlTaTeJlbMAX paccTpolicTHax mo3roBoro
H mo3welmosoro THna cKopee HapymeHHem
ripH AHHraTem.Hbuc paccTpoticTBax m031'oHoro
cHa HJIH ricHxwiecKHm 6eCHOKOriCTBOM, a
B cilygae 3KcTapanHpamH,THimx nopa>KeHmil ?
MOTOpHbIM 6eCITOKONCTBOM.
AnkrrenbHoe HpHmeHeHHe pe3epnima xopomo
nepeHocHTcH Kai< B cnytiae npeo6.na,RaHHH
nopa)KeHHH ABHraTenbHoil Ropm, Ta}( H ripH
paccrporicTBax ABH>14KAeHHH. BosibHbie 3KcTpanHpamHA-
HbIMM nopa>KeHHHmit To.nepHpyloT JIHUM 3Ha-
tIHTeJlbH0 meHbame ;103bl, KOTopme Bce-TaKH
o6ecnelmaloT no.nommTermHbai TeparieHTH-
tlecKHri 34)(DeKT. B xrux c.nytiaH x npeAen nepe-
HOCHMOCTH OTMeLleH He COHJI4BOCTI310, a pac-
CTpOriCTBOM cHa, HBIleHHHMH B036Y)KikeHHH
HJIH HCHXHLIeCKHM Hanpm-KeHHem.
BOJIbHbIe, urpa,rkaioulHe npeumymecTBeHHo
ABHraTe.nbHum HopaweHmem KOpbI TOJI0BHOr0
mo3ra, nepeHocHT 1-TMOTaMHHOBY10 KHCJ1OTY
B MeHbIllerl mepe. Ye He6pm:dime )103bI
MOrYT BbI3BaTb AHHraTe.nbHoe 6ecHoKoricTBo,
Aa H 3nwnencmo. FlpH pacciponcTBax M03-
wetllonoro H 3KcTpanmpamHAHoro xapawrepa
1-r.THoTamHHoHaH KHc.noTa xopoulo nepeHo-
CHTC51 H peAxo HOSIBJIHeTCH.
BbnueH3.noweHHoe HMT 3HatieHHe npeNgke
Hcero C TOT-IKH 3pempa ripaBH.nbHon )10311-
pOBK14, HO HMH MO>KHO HOJII330BaTbC1 H B )114-
(Pepef14anbHo-imarHocnyiecKllx
26
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
113 1 mepaneemwteatozo omdeneuun 6ydaneutmoicil 6c11butupt
;la yi. I7emepg5ulaudop
XiinutoTepanumnecKne. H Kinnillvecgme HC-
CileA0Baillifl BeHrepoon 110J1yCHHTeTHileCKHX
I1p0113BO1HLIX IleHHLIHJIJIHHa
31. 614P0
Ba>KHOR 06J1aCTb10 KJII4Hi4lieCKOR 4>apmaKo-
ROCHH cturraeTcg H3YlleHHe HOBbIX aHTHM14K-
po6Hbix cpeAcTs Aanbxeilmem :
Cneumanbxbie npo6nembi 3T011 o631ac-rm 4>ap-
maKorion44 c.riellyionme : o6pa3osaxvie pe-
314CTeHTHOCTH K neKapcisam, a TaK>Ke 113-
meHeH14e xapawrepa 6o.ne3Hm 14 YCJI0B14R
HMMYHHTeTa Y 60J1bHOTO.
KnmxidgecKaH cpapmaKosiorkm Aon>KHa 3aH14-
MaTbC4 conocTaBnexHem HOBbIX ?amc" c y>Ke
y11oTpe6315tembimll cpeAcTBamm He TOJIbK0 in
vitro 14 in vivo, HO 14 B MOAeJ113HbIX aKcnepki-
mexTax, B KOTOpbIX 110A011bITHOC >KHBOTHOe
nonYtmeT TaKYI0 >Ke neKapcTsexxym KOM-
614HalA1410, KaKosa B KJIHHHKe AerICTBHTeJlbHO
ripllmeHHeTcH (Haripllmep, cotieraHne c r.ntoKo-
KorrllwoH)Iamm).
Bonbume sHllmaxlle caeAyeT YACJII4Tb npa-
BHJIhHOMY B13160pY 60.11bHblX. 110JIYIleHHbIe
B Hersi>Kenbix cxyliasix pe3YJIbTaTb1 He scerAa
Y6e;(14TabHb1, a c ApYTOr1 CT0p0Hb1, B 6e3Ha-
The)KHbIX CJIYIlaRX OT HOBbIX ?amc" Ile.T1b3g
27
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
OiK11;jaTb 110110XCHTeJlbH0c0 34XileKTa. Y TH)Ke-
J1b1X, Ho He 6e3Hai4eN{Hux 60J1bHbIX
(PapmaKoRor HOCHT 60JHALIY10
OTBeTCTBeHHOCTb, oco6e4Hio B Tom cnymae,
ec.ru4 14Me1OTCH H apyrae, ywe H3BeCTHble
?amc". 1/Imermo 1103TOMY oqe Ba>KHO,
IITO6b1 KaK in vitro HCCJIej0BaIi141L TK
oftcnepamenTaiibHue aKm4Halleckme menu-
Ta HI454 6b1J114 npoexTmpoBanu no eAPIHOMY
TII1aHY.
11CC:le,140BaHH51 C MeT141114.11J114H0IVI 14 OKCaLIHJI-
JIHHOM 6b1J114 npoBejelim 110 TaKOMY MeTO,RY.
B KoHuewrpauaa 3 y/m.ri 3TH aaa nexapcTsa
in vitro OKa3b1BalOT, COOTBeTCTBeHHO, 92%-
i-toe 14 97%-Hoe 6aKTeprua4aHoe aerturBme Ha
no.uipeamcTeHTHbre II1TaMMbI Staphylococcus.
TegeHme cTacimacacoKHoBoro cencmca y Mbl-
'Berl 14337,4aJI0Cb Ypa311bIX rpynn 110,a011131THbIX
>K11BOTIlblX, a 14MeH110 : HenegenHble
11 JT'lH-
Hbl a) nelimum.anaHom-G, 6) MeTHLIHJIIIHHOM
14 8) OKCaL114.11.11HHOM. ECJIH B JBYX riepBbix
rpynna X CMepTHOCTb Jocnirma COOTBeT-
CTBeHHO 80% 14 60%, To cpein4 negeHribix
meTnhannanom 14 OKCaLIFIJIRHHOM )1(14BOTHbIX
na,le-/Ka BoBce He 6b1n0. naninwrina-
Tia3b1 HIM npeaumaonoaa He 143MeH5411a npo-
lteHT nepeataBanya, Ho B 143BeCTH0c1
CJIN.7,4aeB HOBJIHAJla aa 110J10)K14Tel1bHOCTb
?6aKTep140110F1411eCK14X peay..nbTaToB.
flp14 KIII4H1411eCKHX 14CCJIe,TIOBaHHHX meTanan-
JIIIH 14 OKCa1114J1J114H Bo Bcex OTHOLLIeHMIX
oripaB,Ibmann OTJ1Ht1HbIe 3xcnepameHTanbubre
Ilpa Bbl3BaH11131X pe3acTeHTHb1Mn4 urrammama
CT411/10KOKKa 3a60.neBal1141X MeTHLIHJIJIHH
H ofccanasumu aaBaJn4 ny4a14e
pe3y.lbTaTm, gem pal-1mile npamengembie
?amc".
28
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
7
113 I mepaneemugeoNeo omdenenuR 60/1bl-1114bl um. Muun6arta,
z. Bydattewm
344eKT npenapaTa renapnnowt npn o6nn-
Tempoinem aTepocKnepo3e
BYrAP-MECAPOLLI KYCTOIE
Tepanewnitiemoe nclluTaHme npomasoalinocb
Y Bcero 46 6011bHbIX (33 NLYNNHHH, 13 wet-l-
aw-). 42 tle.TIOB exa ripmfilimano Ta6.71eTKI4
renapluiollA (npowi-cr 3aBoAa reAeon Pkix-
Tep) B Tegame 6 meunleB, a tiasepo 60J1bHbIX
B Tegame 4 mecgues, CYT0,11-1b1M14 aoaamm
B 3X1 non.
29
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
:DIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
IA-RDP80-00247A002000030001-4
KoHuy wecToro mecynta paccTomme cno-
CO6HOCTH X0,alab YBeJIHIIHJIOCb B cpe,aHem
c 155,4 m o 310,7 m ; YmeHbuieHme pac-
CTOHHHH Ha6moila.noch JIHIllb B 3 CIIYIlaHX.
OCIAHJIJIOMeTpH4eCKH14 II0Ka3aTejth
KOHIAY mecToro mema B cpeilHem
Ha 64,5%; OH CHH>KaJICH TORIDKO B 4 cay-
liaBx. Cpe,aHHH YpOBeHb 06UU1X JIHHOH,a0B
B Cb1B0pOTKe HOB131111aJIC1 C 1668 mr% BO
2-OM mecHne Ao 1774 mr% ; B ikanbHernnem
0Ha CHH>KaJIaCb : K KOHLIY 4-ro mecnta ,ao
1604 mr%, a B KOHIAY 6-ro mecnna Ao 1602
mr%. Cpemiee 3HatieHne tiacTHoro 6eTa/a.nl4a
JIIIII011p0TeHHOB e,IIHHCTBeHHO He 113MeH5lJI0Cb.
IC KOHIAY 6-ro mecsina cpeaHnsi Benntnnia
xonecTepnHa B CbIBOpOTKe ? nocne HeKOTO-
poro HatiaimHoro CHH)KeHH51 ? HOBbILLIaRaCb
C 251 mr% ,ao 281 mr%. CYT0t1Hb1e ,TIO3bI
B 3x 1 Ta6.n. He BJIH1III4 Ha cBepTbmaHne
KpoBn. reMOpparHtleCK0r0 OCJI0)KHCHHH HJIH
Bpyrnx Bpe,aHmx no6o4nmix sIBJleHifil He
Ha6J110,11,aJI0Cb. BOJIblibIe 06bIt1H0 coo6utan4
06 YJIYIIIIIeHHH CaMOLIYBCTBH51 H annemTa.
BBHAY Toro, TIT? HenocpeacTBeHHoro 344eKTa
npenapaTa Ha .nnnonam B }Tom,' He o6Hapy-
WHBH.TIOCb, YJIYtallefille KJIHHHtleCKHX ripm-
aHaRoB npnnnchisaeTcH AeHcTBkno npenapara
Ha o6meH BeulecTB B cTeHKe COCYJA0B.
30
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
8
113 mepaneemuttemozo orndenernin Medut4unc6ozo riu6epcumema
?Eearizeitu3moc" 6 2. AOuttax, FpeguR
Jimmie xpornmecKon ame6Hon )1113eHTeplili
T. 1:40KCPIAAEC
B caytiae ame6Hoil H1lelleKL1HH 60J1b111HHCTBO
!valid' ;to CI4X flop Aymano o6 ame61-1al
3eIrrepm4 HRH o6 ocTpom a6cnecce negeHH ;
TaRlle ci)opmbi HHcDeRnHil Ha6moLta1oTcH qaie
Bcero B TponmecRnx cTpanax. B YCROB1151X
ymepeHHoro >Re RrnimaTa BurpegaeTcH cRopee
cpopma xpoinitlecRoro ame6Ha3a. BonbHme,
o6mtmo, cTpaAmoT OT We.TIYAOIIHO-KHWegHbIX
H.na o6un4x paccTpoacTB, npHgem ame6Hoe
npoHcxow,ReHHe 60.11O3HH ocTaeTcH CKpb1ThIM.
Tem He meHee 113BeCTHO, qTO Y BbICOKOTO
nponewra HaceneHHH B KHWellHHKe HaX01SITCH
aivie6w H 06b111H0 'ramie J111113, 0111H6011H0, npH-
3Ha1OTC51 3,11,0p0BbIMII HOCHTeJIHMH.
B CBS1311 C 3T14M BcTaeT Bonpoc o netieHHH
nepBog rpynnu 14 Heo6xopxmocTB RelleHHR
311411, OTH0CS11W4XCH KO BTopoil rpynne. aiie
Bcero B o6ellx rpynnax Ha6moAaeTcH, 'Tome
ame6Ha3a TOACTOil KIIIIIKH, TaR>Re H nopa>Re-
HHH negeHH. Tatum o6pa3om, !Taw npx-
X0,1114TCR 11p0B0,1O4Tb KYpC neueHHH npoTHB
o6oHx BkmoB ame6Ha3a.
j_joRnaLt nocsHulell TaRoro poAa xpoHnue-
CKOMY Relle111410.
31
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
31A-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
9
Hz mepaneenumecKozo oindeizeHun Focydapcmeamozo LIFICI7711-
myma omiazozuti , z. Sydanetum
Kannna0-4)apmaao.norwtecaoe ncuieikosa-
npenapaTa Mnenoepomoa (JBM)
III. 31-K1-APT m FC.
MHeno6pomon ripeacTaHnHeT co6ort WITOCTa-
TiviecKoe cpeAcTHo, HpHro,a,mnueecH HmeHHo
K .netieHmo xpoHHHecioall 11114eno HAFT o net-
KemHH. HacToHHHA AoKnap, 3aHHmaeTcH
MaKOJIOnilleCKI4M14 OCO6eHHOCTSIMIT ileKapcnia
Ha ocHoHe Ha6mogeHmr4 Y 40 6o.rn,Hbix
32
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy CIA-RDP80-0 0200 001-4 Approved for Release 2013/11/26:
0247A00030
(30 60.11bliblX XpOH1411eCK0171 Au4enounHoti
jieii-
KeMMC11 14 10 OJ1bHb1Xnpyrumn 3noxa1lec-
Belli-lb1M11 3a6oneHa1I41Nui).
MeHelibni Br? Mileno6pomon 6bicTpo Hcacm-
Haenn 143 wenynonHo-xmnenHoro Tpawra.
Oxon() 10% npHHHToro xo.nkinecTHa Hpena-
paTa o6HapY>KHHaeTc1 H RpoH14 11>Ke gepea
10 MI1HYT nocne npmema. Ypos elm CH14>KaeTC54
5114111b nocrenemio 14 H Kp0B14 nawe 2 CYTOK
CrlYCTS1 Ha6n1onaerren eule 3Hani4re.abHoe KO-
JIIVeCTBO EM. Y ti0J1131-1131X xpoHntlecKoil
5114MCDOH1HOr4 ner4Kem14et4" KoHneHTpanHoHnag
HI14Ba1 npi4H0maur paannimbiR BHA.
Mme.no6pomo1, 110-B14;114MON1Y, 13.511451eT cnew4-
(1)1414ecx44 na rpaHynono33. Mccnenosam4H
Koc-rHoro moara 14 KapTHHhi nepH(1)epHnecxo14"
xpolan noxaaa.n14, L1TO KJ1eTK14 rpawYnono33a
ymeHbuialoTcH vwe non ,ii,eilcrrHmem Taxxx n,oa
ABM, ItoTopme Ha 3pHTpo- 14 TpON16011033
ewe He BJIHRIOT. 3TO nonToep}knaurcH14 KJ114-
1114tleCK141Y114 peaynurarrarkw, AOCTI4FHYTbIM14
npnmeHeilHeivi Mmeno6pomona. flpenapaT OT-
J114,4110 npnroneu 1< 11p0i10.11>KI4TeJlbHOMY T10):1-
Aep)4KHBaTboi YIKa3aHHbIX ripm-
1.114110B ? 3T0 cneityeT 111-1,11HBHAYaJ1bH0
06CY)KaaTb, B 3aBlICHMOCTI4 OT ikalmoro 3a-
6onesam5 H OT IanHoi ITY1-111b1 HeKapCTB.
flpoBeAemime Y 3,110POBbIX mill 3KcnepiimeH-
TaJ1bHble mccne,Rosam454 B onpenenemmx
YCJI0B14FIX nal-0T BO3M0>KHOCTH MTH
113Y4eHH51 COHYTCTBYTOULTHX 11/awr0p0B. Cneao-
BaTenbrio, Taiate mccnenoBanun He06X0HMbl
npm KnmamecKom mcnbiTaimm naix0ctopma-
KOJI011411eCKHX cpeAcTB, ripewfa3Hatiemibix
;VTR npumeHefinsi B 06J1aCTH Tepallesnom.
C ImeTom napannenblioro npmmellemv nna-
ge6o, Y Ka>moro JIHUa IlpHX0AHTCH ripoin-
B0,1114Tb He mel-lee ABYX HCIMITaH141.
PaccmoTpemime B AoKnaAe HccneAosaHHH
TI0CB5rnTeHb1 Bonpocy o TOM, B 'K14TeJ1bH0CTb
nporymut). CpaBilmBaemme neKapcTsa otte-
C HOMOLL11310 CTaTPICTHIleCKOil inpo6bi ?t".
n0,11131TO>K14BaS1 Pe3YJIbTaT131 nposeiteHttbix
6b1J10 YeTallOBjleHO, 4T0 BbIllle143110-
WeHHbIrl meToA npmroAex ne TOJIbK0 K KJ114-
1-mito4papmaxonormecRomy 143YileH1410 npo-
THBOBOCIlaJ114TellbH131X cpejteTB, HO H K cpas-
lieHHIO AerICTBHH pa3I11411-1b1X j1,03 neKapern 14
OTAellbHbIX upontsoriocriantrrenbxbix .ne-
KaPCTBCHHbIX KOM61411a111414.
3?6,
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
13
143 II mepaneemugeouni CeeedcKozo meduquHcKozo
yHueepcumema
AericTHHe AeHHHHaHa Ha 331- H Ha HapTHHy
Nia3HOTO ,aHa y 60J1bHMX ritherroHHuecHog
ii0J1e3H11
M. cl,al1b,1:04, (1). OBAJ1 11 r. cErrt
C nomouAbio onTENecKoro nnentamorpacim-
liecKoro meTo,g,a Bornttait H tiarzud3e YCTaH0-
M4JTH, 11TO npm MO3rOBOR 43opme ritnepTom4- ?
gecKort 60ne3mi (oco6enno B cnytiae COCYAH-
CTOF0 gpn3Bca) npenapaT AeBiniKan o6ecne-
innaeT nostowriTembnbiti repaneBnItiecialti
344RKT. BBHAY Toro, IITO repaneBTimecKBe
BO3MOWHOCTH ,11,J151 netielillB MO3rOBNX OCJI0*-
HeHHri ninepTonviB Becbma CKYAIMI, Mb! nog,-
Beprm4 3TOT Bonpoc H3Y14eHHIO no HF101,1
meToakme (331'). 1/13 114CJIa 10 60.113HbIX TH-
nepToHmert c 3.nexrpo3nnecl)anorpa4muectuim
HYTeM YCTaHOBJleHHHARH MO3TOBbIMH nopaNce-
HPIRM14, Y 5 tienoBeK 331' noRaaana 3HaliHTCJIb-
Hoe H Y OCTaJlbHbIX 5 ? nocpeAcTBemioe
ynytmenite. B Kaprmie ma3-1?r? Ana suwq-
uieBBe Ba6moitanocb B opxori qacrit crwqaes.
Ha OCHOBaHHH npoBep,anibuc HCCJICA0BaHHrt
,LtermiKali npeAnaraeTcB Arm ne4em4B M03-
roBoro B14,aa rllnepTonwiecKorl 60.11e3HH.
37
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
3IA-RDP80-00247A0020000 0001-4
14
Ha II mepaneemuyeacoti Knuttuicu Eydanewmetwoo Ateduqua-
ocozo plueepcumema
Kamm go-cpa pma xononnec Roe H3rfeinte po-
THBOaHITHO3H blX nexapcTs
h. rABOP, 5. LIIHMOHH x B. KEHE3
ConnacHo conpemeHHomy HOHHMaH1410, npm-
Innia rpsTAHoil ?Ka6bi 3aKmotmeTcH B pac-
CTpOrICTBe o6meHa HemecTH, Bbl3BaHHOM rH-
noKcHeg cep,aelmon MbH1114bI. no ,aaHHIAM HO-
?BegLIMX HCCIle,a0BaHHri, noTpe6HocTb .MHO-
KapAa H KHc.nopoAe pewaloumm o6pa3om
oppe,aenHeTcn 0611H4M KpOBRHbIM itaHneHnem
H HpemeHem Bbl6paCbIBaHMR KpOBH : 113 zpo-
Hase,aeHHH 3THX ABYX BeJ114,114H 4101117,4aeTCH
T.H. BeilHqHHa AaHneHHH-HpemeHH.
IlocneAHRH HenntmHa onpejlemanacb Y 3A0-
p0BbILTH414; B aajlbHerlIlleM OKa3aJlOCb, 11TO
Y 60J1bHbIX KopoHapHbINI cKnepo3om 3Ta
He.rmtnifia Aawe B COCTORHHH HOKOR 110BbI-
weria Ha 11pH6J114.3HTellbH0 30%. Hoene rin43H-
tiecKai HarpY3KH Ha6moikaeTcH eine. 60JIb-
'nee pacxo>meHne. FloA BAHHHHeM HeKoTo-
phix HpOTHBOaHTHHO3HbIX neKapcTH paamma
mexmy naTonorpriecKoti H HopmanbHoil Hen1-
1114HaMH CHH>KaeTCR. M3MelleHHe CY613eKTI4B-
Horo COCTORHHR 60J1bH1DIX XHAHT HaPaJPIenbE0
H3MeHeHl45IM BefH4414H131 gaBneHHR-BpeMeHH.
38
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
1lA-Rnp80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
15
113 III mepaneemwtecRoa KAUHUKU BydanewmcKozo meduquit-
CIL000 ynueepcumema
K AeriCTB1140 HeKoTopmx HOBIAX ?aHTHJ11411e-
MIMCKHX" neKapcTs npu aTepocKnepo3e
rEPE
Ha OCHOBaHHH npoHeTteHmAx npm KJIHHHKe
HCCJIeTIOBaHHR C0061HaeTCH 0 TOM, 4T0 T.H.
?awrwrifinemiviecKHe" neRapc-rHa paaramHoro
THna .(krpomml, ATpomHA-C, krepowk, ana-
cTaaa, ,11,-TzpoRcHH) KK HOBJIHHJIH Ha COCTaB
CH8OpOTO4HbIX JIHHOHAOB (xonecTepHH, 'rpm-
rsaulepHabi, o6H11111 mtnomit, 6eTa-mmonpo-
TellH asibilia-YmnonpoTeHH).
39
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
16
ha lIncmumyma zemamomeuu 6 z. Bapumee, 170.1buta
IlpHmeHeime rH,RPOKCH3HHa RPOTHB peaRum4
nocne nepeinthaimo xposit
3. rMYP3HHCF(14, A. TP09HOBC1-04 r. FITIEBHFICI-(14
78 60.T1bHbIX B 240 cnYclasix netninocb rfni-
poKcn31nom 'Tomo pa3HbIX peantlirl nocne
nepennnannii "(pouf. floj BJIH1H14CM BHYTpld-
BeHmoro nneTtemin 50-200 mr rn1poKcii3nna
peaKunn nctie3anu Y ncex 6onbubix. rBP,-
pOKCH3HH B 3HatiliTellbHOR mepe cnoco6cTnyeT
143bICKaHHIO meanbnoro cpeAcina ITOTHB
peaxunit nepennnannn xponn.
40
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
17
113 II mepaneenumecKoii HAUHLIKU Eydanetumeriozo meduquit-
cgoeo yrweepeumema
KnatinmecKasi onetwa coemmeimil aHTHELT1b-
Aocrepoimoro )1el1cTro1R
3. Y.T1A3 1.11YrAP
,anarBocTutlecKoe 14 TepanomplecKoe 3Ha-
unvie npenapaToB awmanbAocTepolmoro
;wticTBBR Bee HapacTaeT. Cimia rpynna 3TilX
neRapcTB (nporecTeport, crwpononaKTon)
B.TIHReT nyTem KOIWYpeliTHOr0 nop,aB.TiemAR
1eriCTB1151 anwkocTepona, Apyrag>iKemmm
JeriCTBHH, TaK KaK H3BeCTHO, qTo aHTPIanb,I1,0-
CTepOHHbIii 341IRKT mcex neKapcTm, Aa>Ke npm
AJIMTeJlbHOM npmmememmm, 1114LLIb mpememmbitl.
ilpmmmma 3T01'0 3aK.T11014aeTC5 B 1-10Bb1 111eHHOR
BT0p141-1HOi1 mmpa6oTKe anbAocTepoma, Kom-
nemcmpylower4 noTeplo maTpmm.
MbI m3ymaJII4 npemmyinecTma COBMeCTH0F0
npmmememmm aHTHaJ113,11,0CTepOHHbIX npena-
paTom pa3mai T01K14 npmnowemmm ,RekTmmm
Y 60JIbHbIX, cTpanafouwx BTOpll 11HbIM rmne-
panb1ocTepomm3mom (AeKomnemcanmm cep-
Ana, umppoa cepAemmoro npomocomQemmm,
mecppo3), a TaK>Ke B OrIbITaX. Ha >KHBOTHbIX.
OKa3a.TIOCb, tin) 14YpeTH?1eCKI4i4 344eKT KOH-
KYpeHTHbIX aHTaFOHHCTOB anwocTepoma
cnmponaKToma m nporecTepoma HO-
BbnimeTcsi KOM6HHI4p0Bali FibIM npmmememmem
npeAmm3onoma mnm geKcameTamoma, noAam-
.TIRIOLLINX CHHTe3 anb,RocTepoma ; 3T0 >Ke
1103BOJI1eT npeAynpegyrrb H nombnuemme BTO-
ppmai ceKpeumm anbAocTepoma. Cfamaio-
wee 6HOCHHTe3 anKkocTepoma 3maturrenbmoe
AeacTmme o6mapY>Kmnocb TaK>Ke npm
Ha-
3Ha'ICHHH renapmma, xnopnpoma3mma 14 Hem-
6YTaJla. KOM6HHI4p0BaHHOe npmmememme am-
TkIaJIbAOCTepOHHbIX memecTm C pa31114 11140H
TOtIKOPI npmnowemmm AeAcTmmm OKa3bIBaeT
IleHHY10 nomoum, npm nemeumm OTegHbIX 60.1b-
HbIX CO sTopm4Hum.rrinepanbaocTernmo3mom,
ne 110jUlka10111,14XCH 06bIgHbIM AmypeTmKam. .
42
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
18
113 3naospunoizozuecsoi sjzunusu MeduKo-6fiapma1eemuge-
moeo uncmumyma u uctOedpbt g5u300noeuu 31C1.160MIMIX Yuueep-
cumema 6 2. Kityxce, Pymbuitul
BJ1HHHHe (DeHmeTpaaHHa Ha yp0BeHb ?CHO-
6omoro" H ?CBH3HHHOITI" HHCyJIHHa B HpOBH
B cariae oHuipeHHH
11. r03APHY, P. ,EIACKARY a 0. 43.110PECKY
TepanewmgecKoe mcnonb3oHaHHe neKapcTH,
BbI3b1BalOLIIHX OTKa3 OT eAbi (41eHmeTpa3HH)
ripm o>iKHTenbHumm 14 rpa-
MOTplUtaTe.T13HIAM14 B036Y14TeJISIMH. 1-(pome
KnHHHHecKmx HcnbrraHHii, Mbt onpen,enHnH
tlYBCTBHTeJlbHOCTb 14 11p0143B0,11,14J1 14 TaKWe
mogenbnble 011b1Tbl, noApawatoinHe KJII4H14-
qectuie HEHDeicumm, Ha muulax.
MaTepHan 60.11bHbIX pacnpeaensincH Ha 'rpm
ITYTITIbt, a HMeHHO :
1. 3a6oneHanym 11,blXaTe.1113Hbl X opranon KF(
OCTpble (HHeBMOHHH), Ti( 14 Xp01414,4eCtthe
(6p0HX03KTa314.51) ;
2. 3a6051eBa111,151 opra HOB:
X0J1eIRICTHT H X0J1aHrHT
3. 3a6oneHanHH motienononbix opraHoH : OCT-
pbli 14 XpO 11 14tleCKHR nmeno-
ilecppprr.
HeicoTopue 143 xpoHHHecKmx 60.11bHbIX
panbine ynce Jle1114J1 14Cb pa3nbtml4 allT146140T14-
Kam14 (?camoKoHTponb").
A1nHLuuinnHnpeAcTannsieT c06011 KHCJIOTO-
Y41 OpHbIrl, npHmeHHembni BIlYTpb npenapaT
neHrnAHnnitha iumpoKoro cnexTpa n,e14CTB1V.
B nponen,eHnbtx in vitro 14 in vivo HccneJo-
Harnmx Amnmumninni oKaaancH 6axTepHu4n-
HUM 14 KIII4H144eCK14 3CIARKTFIBHbIM CpejCTBOA1
ne TOJIbK0 HO TpaI11414140HHOMY IleHl4LII4J1J114 if 0-
BOMY cnexTpy, HO 14 npoTHB rpamoTpkinaTenb-
MAX no3617-AHTeneit flo cpanHenkno c xnopam-
4RHMKOJIOM 14 TeTpannxinmom 014 HmeeT npe-
HMYLLteCTBO 6aKTepHLIHAII0F0 J.euiCTB141, 3aT0
011 Bbl3b1BaeT 60.11bIlle anneprwiecKH X SIB-
4.5
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001 -4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
:DIA-RDP80-00247A002000030001-4
20
113 Tepaneemuyeacoa ICAUHUKU Meduqunoweo yliumpcumema,
z. 3aape6, 102ocnaeuft
06meH weae3a y 6onbHmx remoxpomaTo3om
BO Hpemn npHmeHeHHH HpenapaTa ReetPep-
paa
A. XAH H M. KESIEP-BALIOKA
Lo H BO Bpemm memenmm
BsoAllmbim npenapaTom ,Ilec(fleppam (npoilsiKT
6a3embacoro aaBoAa Lin6a) maytiancm vpo-
BeHb weneaa B cbmopoTKe H KOJIHtleCTBO
Bbmenennoro c motioH weneaa. Omiospe-
MeHHO onpeAenwricm Taxwe YpOBeHb mean
46
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
B CbIBOpOTKe 14 KOJ114,4eCTBO sbuteneHHori
13 moue mep,H.
no cpasHeHmo c 14CX0HbIMH senksillHaMH
(Ao Hatia.na Kypca .neueHms), yposeHb weneaa
14 meat B CbIBOpOTKe BO spots Teparillu He
H3MeHHJIHCb.
OAHaKo, cpasy >Ke Houle nepson Aaum )1,ec-
4>eppa.na, "(oilmen's? sbiaemeHHoro c motion
>Kenesa 3HatIHTeJlbHO YBeJ114,44JI0Cb Fl Y He-
KOTOpbIX 60J1bHbIX B TeueHme CYTOK OHO ;lame
,aocTHrano senumH OK. 80 mr. Y Apyrkix >Ke
60J1bHbIX KOJIHIleCTBO sbmeneHHoro >Kenesa
OCT3II0Cb onee HRH meHee HeH3MeHHbIM
Aa>Ke no BJIHRHHeM pa3511411HbIX AO3 Aeupep-
pana. Y>Ke uepes CYTKH Houle sse,aeHHs
nocne,aHeri ,ao3b1 ripenapaTa, KOJIHITeCTBO BbI-
Aenamoro >Kenesa Hauano YMeHbIlIaTbCH
14 CIWCTil 2 CYTOK OHO BO3BpaTI4J10Cb K HCX0A-
Hoti se.nHumHe (AO TepanHH).
Ha OCHOB3H4114 sbnnemanoweHHoro npeAno-
siaraeTcH, 11TO ,Ltec(Deppam coaAaeT xopouille
YCJI0B4154 AJI5=1 yikaneHHH nepeno.rmeHHbix me-
Jle3HbIX ileno H3 TKaller1 60J1bHbIX remoxpo-
MaT030M.
KOJ114,4eCTBO Bb1e.11eHHOn C m040 megs BO
BpeMil KYpca nelleHmu Aecctoeppanom He
143MeHRJ10Cb.
47
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
21
113 mepaneenumectrozo omdenenum eopoocirou 60.76111114bl a e.
Thmaylleapoule
14TorH npHmeHeHHH d-nmolocepluia npH OCT-
pMX H XpOHHHCCKHX HIKOKIAHRX MOHeBOTO
Tpawra, yeTORHHHUX K HHTH6HOTHKHM
T. XAIIAC, F(. 1314TMAH a M. cDEPHBAX
B ocTpbix 14 xpoilmecKmx CJIYLIa A X nmeno-
Hettpwra 14 rmenwra, Bbl3Ba HliblX pa 33114
B036Y,I1,14Te.1151M14 14 ywe net-item-lux MHOTO-
1414C.TleHHb1M14 a HT146HOTHKaMI4 14 CTaB WH X pe-
314creHTHbimm, MM Ha3Ha4H1114 (1-404KnocepHH.
Hoene noApo6tioro mccnezkoBauvw mogeBoro
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Tpatcra (BHYTRIBeHHafi nnenorpailm, XpOT
MOIAHCTOCKOM451, 6aKTepuonorntlecialn ana-
J1143 MOt114), Mbl 113174al114 LIYBCTBIITC.T1bHOCTb
swami-n-10r? B036Y,a14Teng K aHT116HOTHKaM
H K 11HKJ10Cepl4HY in vitro. 30 60J1bHblX
B0J1Sala.110 B Texteptte 5-14 Anal unx.riocepuK
itoaamx B 3 x 250 MI', BIlYTOb. MM cneAllim aa
namenennem KJ1141114,1eCK0r0 COCTORHHA, aa
.3BCHTYaJlbHb1MH no6otnibimn AerICTBHRMH ne-
KapcTaa, a TatoKe aa ocaAKom Bmoge H pe-
3Y.TIbTaTOM 6aKTep140J1OrfitleCK0f0 nccneTto-
BaH1151. B 55-60% CJIY1laeB 6b1J10 ,11,0CTHrHYTO
tuninntiecKoe Ft 6awrepnonorwiecKoe Y.T11,14-
waffle.
Ha OCHOBaHl4H nponasep,efinbix na6J-noAennrt
d-Lunolocepnn, npnmengembill io cx nop
SIHWb B KatiecTae Ty6epRynocTaTimecKoro
cpeAcTaa, npeAnaraeTcH Ansi npnmenemig,
KaK aHTH6HOTHK, 11pOTHB 14H(lleK1.111r1motiesoro
Tpatcra, 06YCJIOBJleHHHX pe3HCTCHTHb1M14
LuTammamn. flonytiennble pe3Y.J1bTaTb1 coana-
AaloT c JurrepaTypnbimn aHHbIMH. Ho Fla-
wemy MlieHHIO crieTkosano 6b1 11011630BaTb01
3T11M cpeAcTsom, npnmenytembim CHX flop
14CKJ110,1HTeJlbH0 B cTaumonapnbix YCJI0B1151X,
ailB. 6wiee yAo6noro nellennsi iiacTo acTpe-
qaembuc molleabix HH4RKL114r1 Taxwe H B Lunpo-
Koil npalanxe.
4 49
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
113 c5mu3uampu4ecKozo omoeizetiuti Bydanetummil 6onbnuipl
na yrt. Yatancu u IV mepaneemugeacoti KAIMUKU Bydanewm-
mow meduquucKozo ynueepcumema
IKe141401 YpOBI1B
(DawropoH II, VII, IX, X B Kp0B14, B IlelleH1411
14 npeilynpemp,eHmil Tpom6oam6oi114iectaix
6o.neHaHHi4 noBbaueHme aliTIATp0M614HOBOil
aRTHBHOCT14 Kp0B14 HrpaeT HawHyto p0J1b.
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
IA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
3A-RDP80-00247A002000030001-4
Y-35 60J1bHblX, AJIHTe.T113H0 JIelleHHbIX aHTH-
KOarYJIHHTaM11, MbI onpeAemum aHTHTpom-
6HHOBOe Aer1CTBIR Cb1B0pOTKH Bcero B 80 c.ny-
qaHx. 'CKOpOCTb 11HaKTHBa111114 Tp0m6HHa
xapaxTepH3Hprioulam ee Hemitunia 1( onpe-
Ae.riHnHcb 110 meTogy repenotuna. Bnoc.neA-
CT1314142 nonTopsm HenbiTaHne C 110M0111310
1 %-110t0 TOJIYHAHH6JIaY, Mb! HOJIYLIHJIH BeJ1H-
111HY K 6e3 renapHHa B ?Cb1B0pOTKe (KT).
Paanina Me>KAY ,E1BYM5 BeJIHt1HHaMH (K?KT)
COOTBeTCTBYeT YpOBH10 3HAoreHnoro rena-
pima. ConocTaHneHHem CJIY>K14.11H Aawn,
HHaKT11BaIAHH Tpom6HHa Y 60 3,10p0BbIX JI1111.
1"pyrinHpyg cloaKT0pb1 aHTI1Tp0M6HHOB0r0
AencrHHH Cb1B0p0TKH (K, Kr, cH060AEHArt
renapHH), Ha OCHOBe oAHonpemeHHo onpeAe-
JIeHHOA rIp0Tp0M6k1H0B0ri aKTHBHOCT11, Mb!
BHJAHM, 11TO tleM HH>xe nponeHT npoTpom6H-
H0Hon aKTHBHOCTH, Tem BbIWe noAHHmaeTcH
Cpeil,HAPI BeJIHIIHHa 41aKTOpOB aHTHTpom6HHa.
Tax, Hanpnmep, HH>xe 20% Ronmecrso K
cHo6oAHoro renapHna npHmepHo B Asa
pa3a npeHbauaeT KOJIHtleCTBO B HOpMaIlbH0r1
Cb1B0pOTKe, npmem xo.rnitiecTso renapHHo-
11006HbIX 6eJIK0B (KT) .1.16BblWaJlOCb To>xe
floqTM B Ana pa3a.
0,11,HaKO, BHYTpH OTAeJlbHbIX ITY1111 npoTpom-
614HOB0I1 aKTMBHOCTH (100-51, 50-41, 40-
31% H T. A.) Bbipawaiouve aHTHTp0M611HO-
BY10 aKT1113HOCTb cpaxTopm KOJIe6J110TCH B
/10B0J1bH0 ninpoxmx npeAenax. 1-Cpome Toro,
Y ? OT,ReJlbHbIX 60JIbHbIX, npH Of(HHaKOBOVI
11p0Tp0M614H0B01 aKTHBHOCTH, HOBTOpHble
Hcc.neAosaHHH 06HapY>KHHalat paarnivHble
BeJ11111HHb1 K, Kr 14 renappnia. gym BbIRCHe-
HHH nor? Honpoca Heo6x0Ammo Aa.AbHeilwee
xo.inviecTseHHoe HccneAoHaHHe Apyrmx (Pax-
TOpOB cHepTbmaHnn xpoHm.
62
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-R DP80-00247A002000030001 -4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
29
113 rca0eopta mepaneemueu MeouguncKozo uricmumyma e
z. T6uAucu, CCCP
"legume KopoHapHon He,110CTAT0HH0CTH )(no-
pawnimom H newrpwre
r. KosAnA,R3E
B CBA314 C 60.11b11114M pacripourpaHefmem Ha-
pvweHHH KopoHapHoro KpoHoo6pameHHH,
npo6nema (DapmaKonorHtlecKoro BoaaegcrHHH
Ha BeHetiHme cocyabi HmeeT orpomHoe 3Ha-
game.
nOHCKH HOBblX, 6onee 34:1111eKTHBHbIX He-
men's, Hbthopolmo H crolixo pacunipmouwx
BeHeqHme cocy,abi ripon,onwaloTcH.
63
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
:DIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
1:1A-RDP80-00247A002000030001-4
110 HallIHM.JIAHHUM 1lMeHH0 TaKHMH BeulecT-
BaM14 H HB.J1H1OTC11 OTelleCTBeHHblri npenapaT
? XJ10pa141131411 H IlellICKHrl neHTpHTe.
Y '100 6011bHb1X ITYAHOrl Wa60ri npilmeHH.T114
XJ10paH113HH, a Y 50 ? newrpliTe.
XJ10pall11311H AaBaJICH BO BHYTpb B A03aX
15-25 MT 2-3 pa3a B ACHE., a newrpHTeno
1/4-1 1/2 Ta6JI. B
YAHBHTeJlbH0e CX0ACTBO KJIHHHIleCK0r0 3c1)-
(Deicra 3THX ABYX npenapwroB AaeT Ham npaHo
JaTb HM 11011T14 OJIHHaKOBY10 01ACHKY.
KaK XJ10paHli3HH, Tax Ft newrpwre HBJ1H1OTCH
344teKTHBHb1MH H Ha,11e>KHb1MH Cfla3M011HTH-
lieCKHMH cpeacTHamm, pacwilpsuoumat Be-
IleqilbIe COCYAbl H perYJIIVYIOLIAHMli Kopo-
HapHoe Kposoo6pauleHHe.
1-1pHmeHeHHe x.nopaHH3HHa H neHTpwre He
Bbl3b1Ba1OT naTonorHgecKHx H3meHermil co
CTOpOHN Apyritx 4WH1U.113r1 opraHH3may He
MeHH1OT KapTHHY KpOBH H CY1BeCTBeHHO He
BJ1111110T Ha YpOBeHb apTepHanbHoro AdB.Tle-
eCJ1H He C4HTaTb B pemmx c.Trytiamx ero
HOHH>KeHHA B npe,rienax CYTOLIHOTO gone-
6a HH.
Kpome Bbillle113J10)KeHHOCO, x.lopaw43HH
H0pmanH3yeT nynbc, coxparHaeT ero 3e?M-
HHT H pery.ruipyeT cepAetnibai p14TM.
64
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
30
Ha Atechaco-6uoiwougecKozo ?mama Beecoto3now uncmtimynia
AeKapcmeetintax pacmattni CCCP
Etepsme HTOICH H HePCTICKTHBbl HCHOH11308a-
HMI CHHOHHHOB Ann negeHmg wrepocKnepo3a
M. H. KOHOBAJ-I0B
BeilHOCTb apceHana MeAllKaMeHTO3HbIX
cpeAcTs Ansi newt-Lug aTepocKnepo3a H aK-
TYaIlbHOCTb ripo6nembi rio6vwn,aloT K no-
Hamm HOBbIX npenapaTos B 3TOM Haripab-
Jleffilli. M3BeCTHO CBOrICTBO CaTIOHHHOB CB5I-
3bIBaTb xonecTepim Kpoom. OxiaKo cepbe3-
11b1X 110I1bITOK npaKTmecKoro FICHOSIb30Ba-
1a1l Call0HVIHOB B KamecTse net-tea-max cpeAcTo
rmnoxonecTepuHempriecKoro ,TI,erICTBHA B MH-
p0B01 IKTHK 0 HacTogulero opemeHm He
6bino. BC8C0103Hbal PHICTI4TYT neKa pcmeH -
MAX pacTeHuil (npoci). Typooa A. A.) Julep-
bbie npen,no>Kkin CarIOHHHbI ;1,mocicopem Kab-
Ka3cKoll ARA JIeeHHI aTepocKnepo3a. ripe-
napaT 6bin HCIMITaH B pa3J114411b1X KJIHHHKaX
H pa3peineu K npHmeHeHmo B MeJAHLIHHCKOri
npaKTHKe CCCP noa Ha3BaHmem
KJIHHHK0-3KCIlepHMeHTanblible Ha6.r1IoAem45-1
3a AelicTsllem AHocnomma nposeAexbi cpao-
H1freabH0 c Apvnimm, npmmetigembimx npm
aTepocRnepo3e cpeAcTBamm. floTc Haulm&
Ha6luo,ReHmem Ha XOLI,HJIOCb ()KOJI? 700 oonb-
HbIX OT 46 Ao 83 JleT, Y 60J1131118171 qaCTH KOTO-
pbtx 0MHHI4OBJ1H CHMI1TOMbI npemmyluecT-
BeHllo uepe6panbHoro aTepocKnepo3a, apy-
5 65-
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
3IA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
::IA-RDP80-00247A002000030001-4
rile rpynnbi OJThHMX xapaKTepH3oHanHcb
npomieHHHIAH KamocKnepo3a Will Hp14-
3HaKamH reHepa.nH3oHaHHoro aTepocK.nepo3a.
ATepocKnepo3 coueTancH c mepTomitiecKoil
60J1e3Hb10 pa3.111441I0r1 cTeneHH H He6o.nbu1oe
KOTIPPIeCTBO 601IbHbIX HMeJ1H B mem KJIHHH-
HeCKOM cTaTyce apTepHanbHyto rHHOTOH110.
JletieHme AHOCHOHHHOM no.avvanH 6o.nee 500
60JIbHbIX, HOBOKaHHOM ? 98; cpaKTOpOM
?14" (cyxon COK KaIlYCTbI) ? 25 ; JIHHeTO-
JIOM ? 30 H HHrexcmHom ? 23. 3TH npena-
pan' Ha3HaT-IaJIHCb, KK IIpaBl4J10, B HPICTOM
Hpme H B HaCTH C.11YtIaeB ? Ha (Poi-ie o6big10
ripaKTHxyembix B cratwoHapHux BHTaMHHO-
Teparnm, nege6Horo Ill4TaHHH, HHAMBHAY-
anblio noAo6paimmx (1)H3Hgecfmx ynpa>iKe Tepanewrmiecnai 3(14eKT,
Kai< YHOMFIHYTbIe B JIHTepaTYpe 3apy6ewHble
cpeAcTHa. CornacHo Ha6.r1IoAeHH5Im asTopa,
Hawnytimme pe3YJIbTaTbI HOJIYHalOTCH B TOM
cnytiae, ecfar 3a negeHme HpHHHmaloTeR Y>Ke
palm (cpa3y >Ke Hoene B03HHKHOBeHH1 oTe-
KOB H remaTom), a He TOJIbK0 TOra, KorAa 3T14
11pH3HaKH CHOHTaHHO HJIH flOg BJIHHHHeM
Apyron TepanHH He YJIYHIBalOTCH. IlpH Hme-
waTenHoHax C 061IIHpHBIMI4 TKalleBbIMI4 no-
pa>KeHHHmH H HpH anacrwiegmx onepaumix
pexomeHAyeTcH Ha3-lax-114Tb TpHncHmycK
npO-
rnJ1aKTM'IecKH. PaccmaTpHHaloTcH Aanee no-
Ka3aHH1 K HpHmeHemno npenapaTa H ero
mexa HH3M
70
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
33
143 lincmumyma Oapmarconoeuu Baptuaeowa meduquilowit
arcadeAtuu
0 cnimyamppoutem AeNCTBH11 HOBOTO 11P0143-
BOJAHOr0 amOvramilHa Ha uiewrpanbHyto Heps-
tiro CHCTMY
KYBHKOBCKI4 H 14. MAFIXEP0414K
Coo6ulexue II
B Kai-lease npoTkonweHmH iaqaix Bvim4e4-
KHM H COTpY1HI4KaM14 143bICKaH14111* HOBbIX
Ilp0H3BOAllb1X /3-0eFmminonporm.namitua, 3,
MY11.1141ICKPIM 6b1.1114 CHHTeT143Hp0BaHbI criepy-
maw coep,mienmg :
I. N,N'-614c-(/3-0eFiuminonponvul)-1,2-Am-
aMMH03TaH.
II. N,N'-6mc-//3-3' ,4:-J114MeTOKCH4le1114J1j-
m3oripormui/-1,2-AmammHowaH.
N,Y-6Hc-//3-/3'4'-menineH1lloKuu4emui/
-Inonponmn/-1,2-Amampnwayaii.
IV. N,Y-614c-//3-0eHmm-m3onpoNuq-1,3-
-AmammionponaH.
* 0 COMBHI-IbIX B TY FlOpY COBBIMBHHBX Mbl coo6ual.r1i no c.rw-
gat? II BeHrepcKoil KoHcpepernon4 no aonpocam Tepanmi 11
(DapmaxononviecKnx nceneiloaaTenbcmix pa6oT.
'71
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
".:IA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
3A-RDP80-00247A002000030001-4
BojopacrHopmue J4141'14,apox.noprIAN
BbIllie-
YK3HHbIX coex4HeHmil noAsepranHcb (Pap-
maKonormecicomy 143ymeHmo. [Joule onpe-
Aeaew454 TOKCIIIIHOCTH, If CCJIejlOBaJIHCb Aefi-
CTKIYI 3THX COeatHeHMr1 Ha MeHTpaJ1bHY10
Ilepl3Hy10 CHCTeMY, I-Tows:woe AawneHtte, ne-
p1401)ep1'1tlecithe COCYAbl 14 Ha nriamme MbH
IlautieHHble pe31711bTaTb1 ripHHeAeHbi B Ta6-
JIIIIIHOM Hi-ie, HRH CpaBIleHHH AetiCTBHH :
amcpuramuHa N,1\1'-614c-/#-/3,4-meTHneHAHox-
c44e4H4.n/-143onporamanu4H/-meTaHa n N,N'-
-AmmeToxampem4y1/ - M3011p0IIHJIa -
MMH/-meTaHa.
1/13 LHICJIa 4 HeBHO C14HTeTH314p0BaHHbIX
coe,a14HeHm1i 0,11,1H TOJIbK0 ,TH4r14JpoximpHil
644c-ifi-4ew4n-143onpon14.1ammu/-nponaHa ?
coemmellue M IV ? o6.1aAaeT CTHMYJIHpY-
IOLIAHM MeHTpaJ1bHYI0 HepB1IYI0 CMCTeMY geil-
CTBHeM. AHanor 3TOTO C0e,11,HHeHMH C 3Tline-
HOBEIM MOCTOM OK3.33JICH HeTkerICTBIITenbHbIM
,JaiKe H thecTHxpaTHo HOBbILIIeHHUX Th03aX.
CTIIMYJIMpYIOLLIMA 344eKT C0e,RHHeHHH X2 IV
paBeH crmmy.r14p.mulemy atlxpelay antleTa-
mHHa, HpHtlem, oilHaxo, coeAHHeHme M IV 13
TpH pa3a menee TOKCHIIHO, gem ai4eTamHH.
BHYTpHBeHHOe Bse,aeHme 1-3 mr/xr coegH-
HeH1151 X IV Kowxam 14 Kphicam, HapK0TH3H-
p0BaHHb1M C nomoulbio ypeTaHa, nouH4>Kaer
KpOBRHOe ,aasneHHe Ha 10-40 Nyvt pT. CT.;
HoHimeHHoe Kp0Bs4H0e itarmeHme ripoilon-
}KaeTCSI JIMIllb IleCKOJIbK0 MHHYT. 110CJIe
BHYTIMBeHHOTO BBeileHM51 coemmeHHR M. IV
xpbicam (0,3 Mr Ha Kr), B DKr' Ha6J110,11anaCb
ymepeHHam 6paAHKapw4H. BeAyTcH i.kanbHeti-
lune Hccne,aoHam4H.
12
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
34
H3 Teprineemumecioa ICAUHUKLI yrmeepcumema g e. BroplOype,
cDPF
K HJIHHIPleCKOM 4)apmaKononnt 4ninumpo-
n0n-m14ionumpontinammia (CeroinitH)
T. K. KYLUKE, 43. 3KMAH, M. r. 1,1,1=113HCC i H. BHK
OT.1114qH0 npHrojmundicH K 110-WHI1O rpY
mon >Ka61,1 npenapaT CeroHTHH H onbrrax Ha
iKIIBOTHblX CHIDKaJI yponenb KaTeXOJIaMHHOB
B TKaHRX ; "Tome Toro, OH o6najlaeT H aApe-
HOJIHTIMCKIIM ,11,61CTBIle1V1. B 011b1TaX in
vitro CeroHTHH ocHo6oHmaeT KaTeXO.T1aMHHbl
73
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
IA-RDP80-00247A002000030001-4
113 rpaHyst m031'oHoro c.noR HaAnotietnamon ;
3a pe3eprilmom 3T0 CaMbIll 31:141eKT11HHbIrl
OCB060)114Tenb aMHHOB.
?LOH BbIRCHeHHH Bonpoca 0 TOM, 06HapY>KH-
BaeTCH JIM 3KCIlepHMeHTa.1113H0 YeTaHOBJleH-
HbItt mexaHH3m AerICTB1154 MalIbIX TepaneBTH-
qecKHx Ton npenapaTa H Y tienoBelca, Mb!
npoH3Hoinum HccneikosaHHA, noRa3aBilme,
"ITO 1-10):1 BJIHHHHeM CYTOHHbIX ,103 B 90-
180 mr CeroHTHHa sbuteneHHe KaTexanamll-
HOB H HX meTa6osifiTa ? BaHHJIJIHHO-MHH-
,11anbH011 KHCJI0Tb1 C MOT-1011 YBeJ11411HJI0Cb.
B 10 (113 12) cnytiaRx yposeHb RaTexonamil-
HOB 110B131111a.TICH ymte mule ABYXCYTOIIHOTO
ripHema 180 mr B ;len. FlOCJIe BOCbMHCYT011-
noro npHmeneHHH 180 mr CeroHTHHa B
npH BHYTpHBeHHOM BJIHBaHHH 2,5 MT THpa-
MHHa/MHH, CHCTOJIHHeCK0e AanneHme 110B131-
WaJI0Cb BMeCTO 60 mm pT. CT. Ha 20 mm pT. CT.,
a ivacToymmecKoe BMeCTO 18 mm pT. CT. Ha
4 mm pT. CT. (cpeanie BeJIWIHHbI Y 12 min).
Y Tex we JIHIA CerOHTHH He0,11HHaKOBO HO-
BJIHHJI Ha npeccopHyto peannuo, BbI3BaHHY10
s.nmaHmem HopailpeHanHHa. Pe3YJIbTaTb1
npoBegeHHbix HCCJIeJA0BaH11il 110Ka3bIBMT,
CerOHTMH, B03,Re1CTBYH Ha mexaHH3M
xpaHeHHH RaTexonammon, CHHWaeT MX
YpO-
BHb B TKaHRX. CKa3bmaeTcH, Kpome TOTO, 14
aitpeHanHTHqemoe Aegcmme, Tax Kai< npec-
COpHbai 34X1RKT HopaApeHamma OKa3aJICH
fle143MeHHbIM HRH OCJIa6JICHHUM.
7,1
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
35
143 1. mepaneemtmecKozo onideneuuR 6ydatietumcgoei 6mbnuoi
um. Thurneana
BaHHHHe r4HaoHanma Ha nepHcpepHgecHoe
Hposoo6pauteHHe y 60J1bHbIX o6awrepupy-
1011IHM aTepocHaepoaom
KYCT0111 14 M. BEPEUKI4
C H14>IKe.riaTeimmBai TepaneBTmilectafg
31:1)cpeKT ? H CBaCTBeHHble emy no6olumie
,ReACTBHH. lipmmememme pacTBopmTeneri
B Balla! AHH npeAcTaBnmeT coon Bechima
itomn.nexcmylo npo6nemy. HenocpeAcTBefme
npmmenemme 34114pa, XJ10p3THIla, 3THROB0r0
cnmpTaH T.n. B nacTominee Bpemm camo co60
paaYmeeTcm ; no6oimnle Ae14cTB1434 3Tmx Be-
inec'TB npmamaioTcm mem36e)imbimm. FlpmTepa-
rimm aapoconem npmmemmoTcH Aaablierullme
pacTBopmTem4 (nanpmmep, CoKeTan). Ba>K-
HbIM'BOIVOCOM ctarraeTcm ,aencTsme paammx
pacTBOpmTenell npm npaKTmecKom HX HC-
110J1b30BaHHH B 06J1aCT5IX 11p0MbILLUIeHHOCTH
H Aomammero xoamilcTBa.
Oco6oe maxim-me Bonpoca pacTBopmTenen
3aKinotmeTcyl B CBOCO6H0CTH Bcacbmam434 (H3
KO>K14 mm4 .nerKmx) 14, r.riaBfnam o6pa3om,
B cpo,acTse 1< nepBumm TKaTIHM. B noc.ne,amee
Bpemm mmeioTcm coo61nemmm n060immix AO-
CTB1411 pacTBopmTenerf (Kai< TepanesTmliecKmx
cpeAcTB) npm oTwospememom noTpe6nefun4
crimpTa.
,EVIH KJIHHHIAHCTa 3TH B0IW0Cb1 mmeloT twe3-
B1,4110114? Bawnoe anatienme.
42
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
41
113 II mepaneemugeacort munuxu Re6petlexcKo2o medayunctcozo
ynueepcumema
CIMBHIHTeabH0e funnum-cpapmaKonorme-
HccneAoBatute aTponnna H npenapaTa
II pillow
Thb. MON.(141(, A. gbEla4:1311, Ill. ,110B1,1 a T. FIBOP
C nomoulmo pa3HbIX icr1mmmo-4)apmaKonorn-
tiecKllx ripmemos, CpaBHHTeJlbHbal aHaJ1143
0613eKTHBHbIX AeHciTHil aTponvma H ripena-
paTa FlpHamllp, (2,2-AH4)emin-4-)l11H3onpo-
rainammio6ympamviA-menumoAHA) 6b1J1 npo-
BeAert B 80 CJIYIIHHX R3BeHHOVI 60J1e3HH.
83
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
:DIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
ABTOpb1 flp0113B0,11,11J114 cneilyiounie npo6bi :
Ha6.r1io,tteHHe MOTOpHK14 WeJIYAOL1140-KHIlle4-
HOTO 'TagTa npH HOMOLI414 6aJ7J10H0100.10-
rpagmn; onpeiteneHHe BbIAC.TleHHH Y110MHHY-
TbIX JleKapcis C >KeJ111610, M011011 H CO CJHOHOR
[10 MeTOAY Mamyca (Ha 1430J1Hp0BaHHOil
I1011,133,110WHOR K14WKe mopcKoil CBIIHKH) ; on-
peaeneHme YpOBHR HeCBH3aHHbIX neKapcTH
B cbmopoTRe H HX CB13b1BaHHe C 6e.rixamm ;
Ha6i11oAe1me onopowHeHHH wenyAxa no me-
TOgY paaHeAeHHH KpacHTemi ; Ha6moaeHHe
AertcTmiR 3THX neKapcm Ha cexpenwo >KC-
J1YAKa H OK0.110Y111HOrl weneabi.
YcTaHoHneHo, o6a neKapcTsa xopowo
BcacbmalOTCR 143 wenyiloinio-KHwetworo
TpaKTa. ATp0IIHH o6Hapy1KaeT cexpenHio wenywa. Manbie Aoabi He
aaji,ep)foinaloT HF! onopowHeHHe, HH MOTO-
pliKY yge.nyouga. epea 3-4 tfaca Hoene ero
BBeACHHH aTpOITHH Bb1AC.T1ReTCH C MOT-10/1.
110143MHA ripeAcTartiiReT co6o1 xoni4HomiTH-
qecKoe cpeAcTso 6oRee YA.11HlieHHOTO
CT81451. B Cb1B0pOTKe o6HapymKaeT cex-
pewno H MOTOpHKY wenyiwa ; 60J1b11114e
)103b1TOpM0351T onopowHeHne wenywa. FlpH-
aMilil Bh1,14eJ1ACTCH C >KCJT(IbiO, M0110A 14 C.T110-
84
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
42
113 liaoopamopuu Cmuc, Kneau u OpCIM A. 0. 6 0. BeIMUI1
CUMU Fapaen, Beinuco6pumatutuR
1431:311THe onpeAeneimmx neKapvre H3 HHH-
HHtleCHOr0 HCH031b30BaHHH
r. 3. ilEAYKET
np14130):1,51TC51 143BeCTHble 06inenpkinnTue
pl4H1AMMIDI AJI51 paneling Bonpoca 0 TOM,
i-1011YCTMMO JIB AanHoe neKapcTB0 giii KI1141-114-
iiecKoro npmmenennB? Hanararionsi jkanb-
nernune CJI61CTBH1, BbITeKa1011.114e 143 3TM X
T1p141-11114110B, wilt-Lem neKoTophie ll114p0K0 1.43-
BecTnbie neKapcTBennme cpegcTBa paccmaT-
pmBaloTcn B CBT e 3T14X CJleACTBMrl, LITO6b1
Olipe)165114Tb, B KaKOrl 14MeHHO Mepe KnnBvt-
i-lecKoe MCM011b30BaliMe TaKMX neKapcTB SIBTIB-
eTcn nenocoo6pa3Hbim. BH0CSITC9 npe,n,no-
>Kennsi no oTnowenmo Kpirrrepnil Aim o6ocno-
Bannoro peuiennsi Bonpoca o TOM, npmxo-
AnTcsi Jill OCTBB14Tb LI,amme ReKapcTB0 B run-,
1114tleCKOM 14CTIOJIb3OBBH1414, 14n0 >Ke MXIATTb
ero 113 o6opoTa ?
85
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
43
113 HaOedpbt g5apmamo.rtozuu u Kag5edpu meduquttacoa xumuu
Meduqunoweo uncmumyma 6 e. Co0uu, BonzapuR
K coapmaKonormi HexoTopmx 11p0H3BOAHMX
THocemnKap6a3HAa
FIACKOB, A. cnAccos, 11. KPYMKOB
)4 E. ral1OBI4HCI-(14
C YlleTOM COCIU4OpaCIIII4p5110111er0 AelICTBI4g
HHKOTHHOBOR KFICJI0TbI Ii HeCKOJIbK0 Apyrvix
1114014)4HHOBIDIX 111)0143B0,14HbIX, Mb! CHHTeT143H-
poBama 5lJ coeumenai (Cnaccoe H r0/10-
8UtiCK11). CIOAH OTHOCHTCH cneitylomme coeAm-
He1-114S1 : KnoprliApaTbr THocemmap6a3oHos
86
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
MeTI4J1-1114p14):114J1-KeT0H0B (2-, 3-, 4-) ; impB-
Awri-anbAerkmoB (2-, 3-, 4-) ; TllocemBxap6a,
30HOB 4anui-4-rimpll,ami-KeTolia ; cemBKap-
6a3oila MeTHJI-4-4114pH,T114J1KeT0Ha ; ca_m T14-,
ocemmKap6a3BA 14 6p0M14CTOB0,11,0p0,171HaSI Carib
meTBR-4-implipLaxerox-mocempurcap6a30Ha.
BbIJ10 YCTBHOBJ1e110, T4TO ramma-rionoweliBe
14 ripmcyTaBme impBABH-reTepoumula Bmeer
Gonbuioe 3HaT4e1414e C TOITK14 3pem4B rilnoTar-
CHBHOF0 jterICTB14.51. Ho csoemy XHM14,1eCKOMY
cocTaBy coeikeliame NR. 19 .(npenapaT Aen-
peToli) npe,RcraBrilieT co6oil menui-4-rnapB-
AmraceToil-TliocemllKap6a3oH, o6naLta1ouikai
caw:4m BbipaNtemibim 14 11p0)710J1>K14TeMbHb1M
114110TeHCHBHbIN1 14 cTamcnriecnt AoKa3ali-
HbIlY1 ABypemtiecimm AerICTBYISIMH. 143YWHI4e
mexaHmama AerICTB1451 coeyweliBB o6HapY-
>Kwrio Becbma Bbipawemioe aApefionimme-
awe 14 Ymepewioe xo.akmosimmtlecKoe Aert-
cTsme. Hatiaelio Ltanee alaaromiallpviowee
AciicTBmgm cepoTomma BJI 14S1H14e. C0e,RHHCHHe
YA,11141451eT ?Bmpa6OTKY 060p01414TellbHbIX
YCJI0BHbIX pegmexcoB H BbI3bIBaeT paccrpori-
cma p,144)epeffu1poBKB.
B BMAY OTHOCHTeJ1bH0 manor! ocTpoil TORCHtl-
HOCTI4 coe,avniaing 14 OTCYTCT131451 rvicTonaTo-
mormliecKmx H3MeHeHHI ripm xpomvieci-mx
onwax, 6bI510 HatiaTo ero RnillupiecKoe Be-
nham-me (JI. Ba6mios, P. Capa(1)oB, M. CH-
mos, B. CnaccoB). OKaaanocb, LITO npcnapaT
OT511111H0 nepeFlocprrcB 60J1bHb1M14 H 06eCTIei4H-
BaeT xopowBil TeparIeBTHIleCKHR 34xoeicr npII
CTBAHRX I H II ranepTolilltiecKon 60J1e3H14
(KBK B 0613eKTHBHOM, TK H B CY6'beKTHBH0M
OTHOLL1eHHFIX). IlapaJIJIeJ1bH0 CH14>KeH1410
Kpossuioro ,RaBriew4B 14C11e3a1OT H CY613eRTHB-
wa.no6m.
87
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
44
113 6o1bnuipt UM. Ce. BaNOROMER 6 O. ROHO011e, Beiturco6pu-
manutt
AeliCTBHB HH1116111T0p0B MAO Ha
KOIMBHTPBBHH 5-mpoKeu-TpHnTammia
mo3rosoft MUIR genoseKa
C. M. B. TIEP
Flo OTH011leHHIO B111451H1451 HHF11611T0p0B MAO
Ha ro.nonHog M031' menonexa ao CHX flop
npHxo,IHnoch cAe.naTb BbIBOAbl TOJIbK0 143
pe3YJ1bTaTOB 011131TOB Ha WHBOTHblX. B nacT-
HOCTII, cooTHowerme mewAsT HameHenHem
KOHL1eHTpaLtHrl 5-rHilpoKaapunTamuna B
FO-
JIOBHOM MO3rY; H aHnutenpeccHnHum Merl-
CTBHeM 14H1'H6HT0p0B MAO OCTaeTCH Hon-
pocom HeBbIHCHellHb1M. ABTOp .coo6utaeT ?0
CB014X Hcc.neTkonaHHHx, nponeAeHHux 3a 110-
leAH1411 roil no onpe,ae.nemno KoHneHTpanHH
5-rKapoKcwrpnnTammia B POJIOBHOM MOM,
Henonexa ; 01-1b1Tb1 6b1J111 Hanpanneum Ha
HuHcHeHne CJICAY101.1111X BOI1p000B :
1. TIOBbIlilalOT .1114 llHni6HTopm MAO KOH-
uarrpatuim 5-FHapOKCHTp1411TaMHHa B FOJI0B-
HOM M031-Y ne.nosexa ?
2. CooTHoLueHme momy Bpemexem TaKoro
po,aa HOBbILLIeHHH H spemeHem liaCTYHJ1eHHA
aHTHaenpeccHHHoro acbcpacra aaH1-1010 ne-
KapurHa.
3. gencTHHe pa3J11/111HbIX ;1,03 HHrH6HTopa
MAO Ha KoHneHTpanmn 5-rHApoKenTpHnia-
mHHa B rOJI0BHOM moary.
4. ,LI,ertcTHHe paaHux cnoco6oH HHeaeHHH
AexapCTB.
88
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
45
113 piag5ed pet nepeubtx done.med PUJICCICOZO medauuncuozo uucmu-
my= u medurco-6uonoeugeoweo omdena BCCCOW3H020 1111CMCI-
myma neKapcmeermax pacmeuud e 2. Puze, CCCP
0111,1T npameaeoasi aHTHKOalryMIHTOB ome-
H 3cay3afta npo COC37,1114CTbIX 3a6one-
BaHlifIX r0.110BHOTO mo3ra
A. C. FIEHCHK, B. B. CrIEKTOP ii M. H. 1WHOBAnOB
AHTIIK0a1Y.153114Tb1 Haxo,a,HT BCC 6onee umpo-
Koe npumeHeyme He TOJIbK0 Alm negeHHH
Tp0m60gr1e6HT0B KoHeimocTeri, Ho H npH
Tpom6o3ax H 0CTaT011HbIX 5IBJ1e14145tX Kposo143-
AHHHHi1 H ronosHoil MO3r.
Ha 93 60J1bHbIX nposeAeHo cpaHHHTenbHoe
KIIHHIV4eCK0e 143Y4e11He HOB01-0 OpHrliHaJlb-
nor? oTeHecTeeHHoro aHTI4KOarYJI9HTa ome-
(1)HHa H HmHopTHoro 3CKY3a1ia, a TaKHKe Ha
KOM614HaUH14 AJI9 JIelleHHA 60JIblibIX TIMM-
60301V1 A?103rOBbIX COCYJOB 14 AHHaMI44eCKHA114
Ha pyineHHHmH M0310B0F0 KpoHoo6pauleHH5L
paammaionwxcH H peayAbTaTe aTepocKnepo-
THHecKoro npouecca.
HaHOosiee 6nar0npH1THb1e pe3Y.TIbTaTbinony-
LieHu H Tex cnvHaHx, re K neHeHmo omegm-
Hom IlpHCTYI1aJ111 B nepHble >Ice CYTKH Hoche
Tp0M6OTHIleCKOr0 1411CYJIbTa (20 Her!) H
CTI4FaJ114 6bICTp0t0 CHHiKeHlig npoTpom6HHa
;10 01tTI4M3JIbHbIX npeAenoH TepaneHTHHeckoil
a1.THBHOCT14.
JleHeHme naHHHanocb c yp,apHipix A03 no
89
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
::IA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
".:1A-RDP80-00247A002000030001-4
150 mr B CYTKH B TelieHite 2-3 ,aHeA HJIH ,110
CHH>KeHH5I.npoTpom6HHa Ao 40-50% c Aanb-
Heruumm Ha3HaueHHem nomepfumaimHx Ao3
no 100 Mr B. CYTKH AO 60 AHeil.
Uenecoo6pa3Ho nepHojklitiecfm noHmulam
nolulepRHHalomsqo iko3y AO 150 mr Ha
1-2 oTAHH.
B rpynne 60.T1bHbIX C OTUJIblibIMH CTORKHMH
OCTaT011Hb1MH FIB.i1eHHRMI4 (22 6onbHbrx) Ha-
6.rnoTkaloTcH meHee HbipaweHHble ci_wHrH B 3a-
BHCHMOCTH OT ,RaBHOCTH HHCYJ1bTa.
110JIYIleHbI 6.naronpHRTHbie pe3YJIbTaTb1 npm-
meHeHHR omecillina B RatiecTHe npocIncnaKTH-
liecKoro cpeAcTHa (22 tie.gosexa) npx Alma-
mpriecimx HapyineHmix mo3roHoro KpOBO-
o6paigeFam c npex0AHuleil noKanbHoR inue-
mHek., a TaK>Ke npll pemHTTHpyioula noKanb-
? Hmemum mo3ra B pe3YJIbTaTe He,ROCTaT011-
HOCTH RapoTHAHoil H 6a3wrinsipHo-HepTe6-
panbHai cucTem, pacHeHHHaloulHxcH Kai<
npeTurpom6oTutiectthe COCTORHIN.
flpHmeHeHme 3CKY3aHa Ha 38 60JIbHbIX c xpo-
HmecKoil nepe6poBaciorm1pHoil HeAocTaToti-
HOCTMO Hc.rieAcTrate aTepocicnepo3a ripHseno
K 3HaIIHTeJlbHOMY CY6leKTHBHOMY Y.BYWIle-
HHIO 6e3 3ameTHoro CHH>KeHHA 1IpoTpom6HHa
H Tpom6oTecTa.
ilpemmyulecTsamm KOM6HHHp0BaHHOF0 npm-
meHeHHH omecimua H 3cKy3aHa (11 60.1bliblx)
RBI's-nom" 6bicrpoTa Ha,11eHHR YpOBHH npo-
Tpom6HHa H 6oRee cTa6mnbnoe cHkoKeHme
npoTpom6mHoHo1i aKTHBHOCTH, 11TO 1103BOJI1eT
pe npH6eraTb KnepHowlecKomy HOBbl-
meHmo noxlep>KHHaloulen )1o3b1 omecimHa.
flpH KOM6HHalAHH ?OMe4MH-3CKY3aH" YMeHb-
LLIaeTCH 011aCHOCTb OCJI0>KHeHldi H OTKpb1-
BaeTc2 BO3M0>KHOCTb AJIHTeJlbH0F0 npHme-
lieFIFIR aHTHKOaFYTIRHTOB.
90'
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
46
fl 11 mepaneernwleocoa KfitalUKU Pe6pegencKo2o medutiun-
owe? ynueepcumema
Cpamurrenbllme Kniunwo-qmpmaKonoritue-
CKHe HCCReA0BaHHH ABM H Munepatia
JC(b. IIETPAHR i W. HA,Ilb
,II,eticTsHe npenapaTa ABM 113YtiaBOCb
Y 60.TH)HbIX ocTpon H xponmecKai MHellOHB,-
Hog netiRemHen, a TatoKe in vitro B neri-
KemwiecKmx H 3B4OpOBbIX KY.T13TYpaX RocT-
noro mo3ra H nepHcpepHqemoti 'KeHo, gem cz.nbHee cTeneHb BpaineHHH
H Yron HaKJ10Ha KOJIbIleBbIX rpynnnpoBox
95
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
49
.143 I V mepaneommiecnozo omdena, cmomamonozuvecKoeo omdena
U omdena Aumpoduortoeuu Bapumeenozo meduqunckozo UNCM11-
myma, 17mm=
.14ccneAosamfe TepaneBnplecKoro 3clxinicra
IlHpplinwipmo-merwri-TerpautiKJIHHa
?n0.1114a"
3. CAA0BCK14, KPACHEHKO, 3. JIETOBCK.14
H J. nPituEscKA
111:241bITO>K14BalOTC53 riepsbie TepaneBTHqemie
pe3YJ1bTaTb1 npktmeHemisi ruipponi4AHHo-me-
THI1-TeTpaLtHKJIHHa ?1-10JIMA" B OTgena
TeparieBTHIGI if CTOMBT0J1011114.
rIpenapaT Haarattancg Bcero 40 6o.nbliblm,
cTpa,Ratouwm p931111t111IAM14 94e11(11110HHb1M11
96
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
6051e314541\114 OH BB0)1,14IIC1 BilYTIMBeHHO 14J1 14
BHYTpH3AbILLIellHO. )10314pol-31(a YCTaHOBI4J1aCb
Ha ocHoHaHHH onpeAeneHHH Yp0B1454 neKap-
CTBa B cbmopoTKe 14 CYTOI1HOTO BbIACJIell 14H
C MOL1014". Ha OCHOBUl414 CepHilliblX o6cneAo-
Hau14rt 60J1bHblX, 14X CY6'beKTI4B11 BbICKa3b1-
BaHl4r1 H pe3Y.TIbTaTOB na6opaTopubix aHan14-
30B itaeTcH noApo6Hb1H aHaJ1143 3(1)4NKTI4B-
1 IOCTI4 neKapcTsa. Oco6oe HHHmaHHe 6bino
yAeneHo COCTORHHIO HapeHXHMaTO3HbIX opra-
HOB, mop()onorm4 KposH 14 4WHK1114 14 cep-
AeHHo-cocyAH CTO ri cHcrembi.
Y 40 60.1bHb1X, nelieHmAx HO 110BOAY pawmil-
HbIX HyKIRKHHrt blXaTeJlbH011 cHcTembi, mo-
HeHoro Tpawra, )-KeJP-IHbIX HYTerl 14 rHOrIliblX
cromaTonormliecKux 3apance111411, 61:1na yeTa-
HoHnema BbICOKaH TeparieHTHHecKaH aKTI4B-
HOCTb neKapcTsa, HOCKOJIbKY B CBbIllle 80%
cnyHaes Hacrynano AnyrrenbHoe ynytnneHme
HJ1I1 nonHoe H3neHeHme. TOKCHIleCKHX H06011- ?
IbIX HsneHHil, Tpe6vioamx npeKpauleHHH
Kypca netteHHH, H14 Y on,Horo 143 60JIbl1bl X He
Ha6mojtanocb.
91
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
'CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
SO
113 11 mepaneemuttecrwil FCAllfitIKU CeeedcKozo hteduguncnozo
riumpcumema
PlateTillie 6yTHactunnaToHa npm runepTomi-
gecKoti 60.11e3HH
)4{. ILIEBEK 14 M. 4EJ1b,E(P1
Flo 3KCIlepHMeHTaJIbHb1M AaHHbIM, 110JIYileH-
Hb1M ,allpHepOM 14 coTp. Y >K14BOTHHX, BYTHJI-
CHMTIaTOH npe,acTaHnHeT co6ori HeaponenTH-
tiecKoe cpeAcTso, HIllmowee Ha Bel? HepBHYI0
C14CTeMY. ABTopamli o6Hapy>KeHo perynHpy-
'owe AeAcTHHe coeamHeHHH Ha KpoHHHoe
gasneHme, o6T,HcHHemoe Tem, TO 143 npeccop-
MAX nenTpos 110,11aBJIHIOTC5 ncerila 14MeHH0
Te, KoTow:a HaX0T1HTCH Ka( pa 3 B C0CT05H1414
B036Y>1?HM51. 34)(1)exT 3TOT CKa31)1BaeTC51 H
H nepmcpepHlieclux penenTopax. Hap, maTe-
pllanom 60J1bHbIX KJIHHHKH 143YllaTIOCb xteil-
cTnme ByTwacHmnaToHa Ha KpoHHHoe AaBne-
Elle, a TatoKe Ha nbuteneHme Ho 3nexTpo-
J114TOB 14 KpeaTi4HHHa. B OJAH14X CJIYIlaFIX npe-
napaT OKa3aJI rHnoTeHcHHHoe H iwypemqe-
awe AdicTBlle.
98
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
51
113 mepaneemuqeceozo omdeeenue rocydapcmeemwzo UHCMU-
myma olitcoeozuu e z. Bydanetume
KAHHIPleCKHR 011bff npnmenenng Benrep-
cxoro npenapaTa annKa-nernco6nacTnna
?BP-8"
K. IIIESMEM H 111. 31-(XAPT
KJiiHHJ4qecKHii 34cbemT npenapaTa ?BP-8"
(B1411Ka-llenK06.11aCTI4H) 143Yl4aIIC5T Y 60J1bHbIX
remo6nacTo3om. 143 o6mero xmcna 30 6onb-
HbIX 24 cTpanano ni4m4orpailynomaTo3om,
3 ? JIHNKDO- HRH peTHKynocapKomoil 14 3 ?
JWYT1M14 3J10KatleCTBeHHbIMII3a6onesalummi1.
99
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
Y Bcex 60J1bHbIX 6o.le3nb maxoinuacb B 111)0-
ABPIHYT0R CTa;11414. ripenapaT ripmmemsLicsi
oKep,mesmo. 20 genomeK no.wilano B Tegemme
20 CYTOK e>KeAmerimo no 2,5 MT, OCTaIlbliblX
10 LiesiomeK ?B Tegemme 10 CYTOK ewexieRno
110 5 311al114T ricer() OK. 45-55 Air neKap-
CTBa. Manbie CYT0,411bie j03bl oKaaaJ114C1,
MeHee TOKCHLIeCKHMII, IleAl 1403b1 B 5 air.
B noc.riejeI rpYnne Y 4 Cio HaCTY1114JI
arpamys1onmTo3, KOTOpb1r4, 014HaKO, cKopo can
C060.14 HOpMa111430Ba.TICA. Y HeKoTopmx Onb-
HbIX HallaJlOCb mbinuemme? BOJIOC.
Ho oTmoinemmo cBoero Tepane,sTmtiecKoro
34xPeKTa ?BP-8" ofmancm 410.11e3Hb1M 1411TO-
crantliectaim cpeAcTs OM 13 cra,amm 111. Amm-
cporpailynomaTo3a : B 3 cnygaRx no.aytia.Tiacb
norniam, a 13 11 ? mac-rpm-fay! pemmccmH. TaK
KaK ToKcmtiecKme Aet(IcTsmsi npenapaTa cKopo
npoxoART, Oil npmruem Aawe K JlegeH1410
60.11bHblX C nopawemium remoncmom14YCTOrl-
1114BbIX K nygeBoil Tepanmm. np14 ,E1,1)Y1-11X
60.1e3H9X 3C14eKT ?BP-8" memee y6eAmTeilem.
011 o6ecnetmaeT .114111b KpaTKoBpemenmylo
pemmccpuo (6-8 neAenb).
Ho MHe111410 aBTopon, Aanbmegwee
mcnbiTamme ?BP-8" npm paa.rnp-mmix
011YX0J1eBbIX 3a6o.neBamm9x 6131.110 661 o6ocmo-
BaHHb1M.
100
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
52
143 me,lurco-buomengeowoo of-llama BCCC010311020 uHanutnytna
nemaperneermbtx pacmenuti 8e. Puee, CCCP
KaminiKo-mop4mitorwiecKan xapaKTepHc-
TN Ka Tomcwiecimx ABJleHHR, B1613BaHHbIX
ceHypHHHHom
J1. Ft CRIIPPEBCF(1411, 14. B. CF(OPOgYMOBA
ii M. H. KOHOBATIOB
liaM14 143Y113JICH HOBbliA CTp14XHI4H011011,06Hblr1
npenapaT CeKYp14 11 14H a3OTHOKHCJIblii (alma-
CCKYpIAHHH ribulenell 143 cetcypHHerm
110.11YKYCTap1411KOBOV1,B HacToHulee HpemH BB e-
;1e1-1HOrt B KYJ1bTYpY B CCCP). CeKYpI4H11H
npHmeHHeTcH B OCHOBHOM npm BHJIbIX nape-
Hax naparimax, rHnoTormn, acTemoiecKHx
COCTORHINX 14M110TeH11 14 14 Ha notme cpyHKHH-
Oliallbl1b1X HepoHbix paccTporicTH.
Y npaKTHLiecKH 3J10p0BbIX mog,eil (8 Ho3pacTe
20-40 .neT) llpeTkenbrioaonsrcrumbie
CeKYpHHHHa Bb1313113310T noBbililenFle pegmeK-
TOpHOrl 1eHTel1blIOCT14, mbnnetnioro TOHYCa,
Mnip1133, memunl Tpemop KOl1enHOCTer1, Yqa-
ntenme Ab1X3HH51 H nosbnueume KpOBAHOTO
.JaH.TieHHH. lipm 60Jlee 3Ha4liTeJ1bHb1X Komi-
LiecTsax npenapaTa, Ha6.flioAanocb npH
cflytiailHbix HHTOKC11Kal114SX B npoymBoA-
.
101
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
CTBeHHbIX YCJIOBHHX, HOHBJIHIOTCH 60J11f
B cepAue, 3HailliTeJ1bHaf1 0,11bIllIKa, C5Ia6OCTI),
IIYBCTBO pa361ITOCTH, TRHY111He 60JIH B MbH11-
HaX pYK, HO!', CIIHHbl, %clue Hel1p0143BOJIHbIe
coxpameHHH MbIWellHbIX rpynn c oT6pacbma-
HHem fOJIOBbI H TYROBHIlla Ha3aA. 3cKnepH-
meHTanbHoe 143YHeHHe OCTpbIX H 110,110CTpbIX
oTpaHneHura CeKYpHHHHOM Y Kpmc C Lje.T1b10
BbISIBIIeHH51mop4t0norwieumx143MeHeHH1 HO-
? 3ano, 11TO TOKCHIleCKHIA npoitecc B cnHH-
HOM H TOROBHOM MO3tY HmpawaeTcH B II03I-
H0RpOBHH M1rK0r1 mo3roHoil 0 60JIOLIKH,
HOKpOBHH, ()Tette H Ha6vxaHHH HmecTsa
mo3ra. FlpH rHcTonormtiecKom Hcc.neAosaHHH
ripH ocTpom oTpaHneHHH Ha6moga.noch Ha-
6YXal-Ilde HepBHbIX KJIeTOK ronoeHoro mora,
Hbipawemibill nepHcpepHgectudi Xp0MaTOJIH3,
KapH0LIHTOJIH3. flpH no,RocTpom oTpaHneHHH
9TH 51BIIeHH51 HbipaweHm B 60JIblUerl cTeneHH
H K HUM npHcoeAHHHeTcH IlepHHelIJHOJIHpHbai
OTeK H 3KcHeHTpHilecRoe no.noweHHe spa
H B,aphiuma. Y >KHBOTHbIX, BbI>KHBLIIHX nocne
mHoroxpaTHoro BBeaeHHH HecmepTenbubix
,zk03 ceKITHHHHa ABBeHHH pacTHopeHHH H
.pacnbuieHHH Xp0MaT01:1914J1bH0I1 CY6CTaHLIHH
B AanbHernuem CMeHHIOTCH ee KoHconHAaHmeti
H YHJIOTHeHHeM, 0c06eHH0 B pa3JIHIIHbIX OT-
,aenax CIII4HH0c0 mo3ra. Bo BHYTpeHHHX op-
raHax o6Hapy>KHHaeTc5I HepaHHomepHoe non-
HoRposHe cocyAoH, memme KpOBOH3JIH5HH51
B mHoKap,a, nerithe, HoincH, OTeK JIMPIHOrt
TKaHH (B OCTpbIX CJIYIlaHX).
OTmegaeTcH owHH.neHme (DH6po6nacTlltlecimx
3J1eMeHT0B Me>KYTOIIHOrI TKaHH napemxilma-
TO3HbIX OpraHOB, 6o.riee HbipaweHHoe HpH
no,RocTpom oTpaaneHHH, YBeIIHIII4BaeTCH KO-
JIHIleCTBO 3HTep0xpomacl9HHHwx KIleTOK TOH-
for? -KHLueqHHKa, coAepwauvx cepoToHHH.
102
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
53
113 1 mepaneenzuvecKoti mut-tutu Sydaneiummeo meduguticKozo
yuueepcumema
TteitcTolle MenimpamHHa (HmHnpammia) Ha
Hp00006panteHHe w o6meH oeuxecTo B rOJI0B-
HOM moary
14. PEB, 1110JIT14, A. IIETEP, M. 14WKYM
14 K. (13 E b E HIM
OcTpoe AeticTHHe MeminpammHa (Hmmnpa-
milHa) Ha MO3TOBOe Kponoo6paineHme H M03-
TOBOrl 06meH BeulecT3 H3YLIaJIHCb Y 11 60J1b-
HblX, HaX0,11,51IIAHXCR B KommeHcHposaHHom
COCTOHHHH cepAna ; onpeAeneHHH npom3mo-
JAHJIHCb Ilepe3 20 MHHYT noc.ne BHYTpHMblaIell-
HOTO HHeAeHHH 25 mr Meymnpammia. BbIJI0
YCTaHOBJIeHO, 1TO HH KOJIHIleCTBO npoTexa-
xnueil tiepe3 r0JI0BHO1I M031' KpOBH, HPI C01-1p0-
THBJI1eM0CTb M03r0B131X C0CYJA0B B OIVHPIM01:1
epee cHHwarnicb. Ilornomenme xllcnopoxta
H TJHOKO3b1 TOJI0BHb1M m031'om Towe He
YXYAIllaJIOCb. BeH03Hoe itaHneHHe B TOJI0B-
HOM MO3rY HemHor0 naAano, npmem MHHYT-
HbIrI o6bem H Rp0H9H0e AawneHme -CYllteCT-
BeHHO HE H3MeH1JIHCb. '
HccneAoHaHHH noKa3anH, qTOAerICTB14e aHTH-
xtenpeccnsHoro H ycnoRaHBapoulero cpeAcTsa
MenmnpamHH Ha mo3roHoe Kp0B006pa1neHHe
B 311aLIHTenbHal Mepe paampiaeTcH OT 13JIM-
AHHR coep,HHeHmti Tmna TmoneHTana-6ap6H-
TypaTa ; iteticTsme MenmnpammHa noxowe
cRopee Ha AeticTsme mopnpoma3HHa.
103
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
:DIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
01A-RDP80-00247A00200 030001-4
54
/13 Illicnumiyma ye06eplVeliet176060HLIR epatica, Bydaneuttn
jlegeinfe ithimpio-annepripiecioro xposure-
:11eHH51 H3 nem x plafteHmem cene3eR KIR H
Ha3HaveftHem p Imo o Ha, xanbwiti-312(TA
H limmypatia
B. LIITEIIHEP
flpm BmmyBo-annepriviectmx KpoBoTegenum
CBIlell3KTOMMI B 3Ha4HTeJlbH0171 mepe
Bp0,110JOKI4TeJ1bliOCTb >K143H14. BmecTo
3Toro aBTO p 3a nocneABee BpemB nimmeumeT
,T1pep,HH3OH CYTOLIHb1M14 JW3MM B 2-3 mr/Kr,
a B Aa.IBBeiluiem Jt eT nomeNKBBa 'mime
104
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26 :
ciA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
;10361 alp Tex nwii, Ka F< 1414C.I10 permtv..44oatir,on
OCTaeTCR i1ordManbBb1M. J1et1p4_1;411tV 40-
011>4ite
1-2 -rona. Ra.nmAnti-DATA n.p.nr.o.Aen .K
4? 25-KpaT11OMY Yoemmenmo KonntiecTsa we-
ne3a, nbinenenuoro mouoti. Hpnmeueume npe-
/
napaTa cweraeTc9 oco6enno ycneumum 13
car/Knx c.nygagx. arm negenmsi cnytiaen
kimmyno-amneprngecKoro KposoTegenng 143
nermix, 6e3ycnewno netiennbix Hpeamno-
110HOM. B nocnmee opem MM nonbrramicu
14er10.11b30B1111149 npenapaTa Hmmypan. ripe-
napaT npeacranymeT co6ori nponanonnoe
.6-mepKanTonypmna, B KOTOpOM KI4CJI0p011,
cynbcDrnnppmbnoti rpynnbi 3ame1en K0.nb-
11,0h1 14M1W130jIa. flpm nom M6I 14CX0141114 143
-npeano.no>Kenn2, wro coeannenne othwaeT
Iimmynnylo peaKumo opramnma na anni-
remmie pa3apa>Kenvm. B 3Hall4TembH0 6o.nb-
weti mepe, gem 6-mepKanTonvpmn.
BOHAN, Toro, WO 00 Hammy mnenmo 3a60-
..neaanne (cturrannoe jo cmx flop accenun-
a JIbHbliN1 nerowwim remock1epo3om) mmeeT
Iimmyno-anneprkmecKoe nponcxownenne,
rmnmenenne Hmmypana Ka3amcb Ham gene-
-coo6pa3nbim. M hi FI0J1b30BaJTHCb npena-paTom
cyToLmbimn J1103amn B 2,5 mr/Kr. iloc.ne MOO-
roneiLembtioro np14menem49 Hmmypana ?
comecTno c Hpeninno.nonom ? Kponoxap-
}canbe B110.111e npeKparwnoch H 3TO YJIY1-111.1e-
Hue ?minnow, itawe noc.ne nocTenennwl
oTmenbi ilpeanino.nona. Y 6o.nbnoro npn3-
11aK14 Y)Ke 2 meoula OTCYTCTI31710T. n0Aep-
o- -/Knnatowasi n,o3a Hmmypana : 0,7.5/Kr.
?
4
1115
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
::1A-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
55
113 Fteeponcuxuampugeexozo omaenenun 6yaanewmcKou riaCt11-
K06011 COIZbUUqbI na yui. Po6epm Kapoii
than, nevenno anrnocnacTngecKnx COCTO-
SWIM rOJI0BHOTO mo3ra npenapaTom ge1314H-
KaH
A. COBOP igb. PIMPE
cDapmaKonorniiecxnmm H KJIHHIPleCKIIMII 14C-
C.TleA0BaHHHM1f AOKa3aHO, tcro afixanonA pac-
Temi Vinca minor ? smixammn (npenapaT
gemixan) ripmroAen K ymepennomY CH14-
>Kelm? 110BblilleHHOr0 KpOBHHOTO TkaB.nennH ;
alxpeKT npenapaTa nmeeT 'velum-fug xapax-
106
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Tep. I HII0TeH3HBH0e BIIHAHHe )21,eHHHkaHa OCY-
IgeCTBJIAeTCA HYTeM IIOHH>KelikIA conpoTHH-
.neHHH nepwpepHliecKHx cocyAoH, npHilem
MHHYTHWil o6bem cep,rma He H3meHHeTcH.
B SHAY TaKOTO mexama3ma AelIcTHHH, ripm-
meHeHme HpenapaTa CIII4TaJlOCb ljenecoo6-
pamum npvi HeHponorkmecKHx 6011e3HSIX, B
KOTOpbIX 3a6o.neHaHme HJ1H 1IpH3HaKI4 BbI-
3BaHbI MeCTHbIM nosbnueHHem HempepHtie-
CK0t0 conpoTHH.TieHHH. CioAa OTHOCATCA
npewile Bcero cneg,yioume COCTORMIA : aH-
rHocnacTwiecKHe KetimnanbrHH ; onpeAeneH-
HbleBHbI H cTamm mHrpem4 H remmxpaHHH ;
4WHKIA4OHanbHbIe COCYDICTbIe ABJ1e111151, CO-
nposowaaloinme BbI3BaHHbIe rpmerrom4ell 11
YTOMJICHHeM TOJI0BHble 60R11 ; OCHOBaHHbIe
Ha JIa6HJIbH014 TnnepTomn4 mo3roBbie }IKa10T Hbulene-
HHe roHaAorponHoro ropmoHa. YCTaHOBJleHO,
11TO 1.111K.111411eCK1111 npHem CYTOIIHOR ,a03bI B
2,5 mr o6mem3riecrHbix npenapaToB Ywe na-
newHo nperiHrcTiayeT aaHaTmo. TaxHe noam
He CHH>KalOT BbLaelleHHH roHailoTponHoro
ropmoHa, o,aHatco, o6b14Hbai npen,oHynHnHoH-
Hblrl 11141< Kpl4B0r1 OTCYTCTBYeT.
011bITbI Ha >1KeHHH 110JIMHTellbH014 peaKnHvi
Ha nACIC. B onbrrax lluuvomtia recTareHbi
IlpelIHTCTRYIOT 143MeHeH1451M 51141-1HHKa, TpaHc-
nnaHTHposaHHoro B ceneaeHxy, 14 HaCTY-
namiudi nocne KacrpanHH HpewnepHoR
Bbl-
pa6oTKe roHanorpormoro ropmoHa.
Ha ocHoHe KnHHHHecKux H 31ccnepHmewranb-
HbIX HCIMITaHHH npennonaraercH, TO Toxixa
npHnonteHHH AericrsHil HaX0,11I4TCH B num-
cinne. Ha nbuteneHme roHaAoTponHoro rop-
moHa Y Henosexa Ma.T1131e ,1103b1 He BJIHRIOT,
HO OHM, HaHepHo, TOpM0354T TpY)1140 onpeng-
JIMMY10 cempenrno moreHHH3Hpylowero rop-
mo-Ha 14 3T0 moweT nprmecTH K OTCYTCTBI410
OBYJIHI11414.
recrareHHoe, 3crporenHoe, aHa6onritiecKoe H
11pOTHBOOBYJI5HHOHHOe TherICTB1451 IlpI4CYTCT-
BYIOT B OTAeJlbHbIX coenHHeHmHx B Hecbma
pa3JIPI4HOM COOTHOIlleHMH. Ha OCHOBe CO6-
cTBeHnoro 011bITa H nwreparypHux naHHbIX
nprmogsyrcH cambie nenecoo6paaHbre B03-
MO>1KHBOTHOI-0
rip( H3bICKaHHII HOBbIX neKapcTneHHba
cpegcTs Tpe6yeT He TOJIbK0 nepesoga 313e11-
TYalIbH0 11p1ICYTCTBYIOLLWX TepanewrmuecKnx
geiicTnuil Ha tienonexa, HO H BbIB0,110B no OT-
Homemno TORCHKOJI0rHtleCKHX BJIHAHHrl. AB-
Top yKa3bmaeT Ha HeKOTOpbIe Ba>KHbIe HOp-
manbFibie YCJIOBHR B opraHax co6axn H
Row 3HaHme KOTOpbIX Heo6xogHmo
(DapmaKonora, no I436e)KaHme ouni6otmoro
IICTOJIKOBaHHR onpegeneHHbix RBJICHHII. Pa3-
smtialonwecsi gpr OT gpyra Y nogonbrrHoro
NumoTHoro H Y tlenoBeKa Ha6mogeHl5i, K
cowanetimo, ogeHb qacTo Ilp143HaBaJIHCb KK
r106011HbIe RBJIeHl4R, csoticTBeHHme HHOMY
sieKapcTsy.
111
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
59
143 14Hanunlyi00 zemarno.iomu, z. Bapulaea, 17o.ablue
peo,aoaeHme pBOTH bI X petneKcos rimp-
oKCH3HHOM
A. TP051HOBCKH a T. 11J1EB141-ICKM
BnoKaAa T. H. xummopeuenropnoil HYCK0B011
30Hb1 (?eheinoreeeptor trigger zone" CTZ)
npegynpe>KAaer B031414KHOBeHlle pBOTHb1X
pect)neKcon. B KJIHHHHeCK01"4 IlpaKTHKe 6n0-
aa CTZ c 11011(101.010 rkrapoKcimmia OKB3a-
JlaCb 30eKTI4BIlb1M, 6e3onacithim 14 17/1,06HblINI
mero,Rom. B xmpypnivecKom orrteRennn I/1H-
CTHTYTa remaronormu 111ApOKCI4314H na3na-
tlajleR Bcero 215 60.11131-1b1M oT1aCTllAAR !veil-
ynpeKlenkin, OT1aCTI4 >Ke Any' netiernisi
pBOTbl. r1penapar ycneiuno ripmmensuicsi pa3-
111411Hb1M11 Ao3amn C 50 Ao 200 mr. flop,AepKii-
naioulaR Ao3a Kone6anach or 50 Ao 140 mr 13
EAI4 H CTB el 11-1 hIM ite>KeRareimnbirvi no-
60qHbINI 1BJ1eHI4em Y HeKOTOpb1X 60J1bH bl X
6b1I10 HYBCTBO CYXOCT14 BO pTY.
B BI4011,Y BbILLIell3J10>KeHHbIX 6.r1}oTon m ,
rtmpoKcinmn ctmraeresi BbICOK0344eKTI4B-
11b1M, 6e3011aCHblAi H Yi1,06H0 npmmetimmiAm
npOTHBOpBOTHEAM Cpe,TICTBOM.
112
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
60
143 k cciteamauneimcn000 uncmumyma 91(cnepumenn1cimmou
ffiapAtaxmweuu Meauguncnou anademuu e Bapumee, Floimum
(DapmaKonorwiecRoe o6cptommie neKapcTs
C TOUKII 3peH1451 ripaKTHKpoulero spava
KYBHKOBCKH i B. PEBEPCKH
AOKJlaj1,-114K14 3HaKOMSIT C o6u14mi4 n1)14111.114-
flaw+ cpapmaKonormqemort otterwm neKaper-
Bel-11161X cpeAcra C TOLIKH 3pe114151 ripatam-
Kvioutero spaqa. B CBS13H C 3T14M OTMega1OTCS1
c.nep,ypoutHe Tpe6oBa
L llacTo yapa4113aTb cneumanbrible KY C 134
14 coBeutaiipm c IlpaKTHKY101111411111 Bpayampt,
113:
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
IA-RDP80-00247A002000030001-4
tITO6b1 OCBeAOMHTb HX 0 HOBerILUI4X Harman-
neHnnx" HCCJIe,a0BaH141 14 0 AOCTPOKeHMHX
conpemeHnon cpapmaKonormn.
4 . BKOLUIeKTHBaX, onpeikenmounix KJIHH 14-
xleCKY10 11pHMeHHMOCTb KaK0r0-TO neKapcna,
Henpememio Ao.rnKen npminmaTh yqacTue 14
timpmaKo.nor.
3. flpaimucytomnx spatien, 065:13aHHbIX 06-
CY>KAaTb HononnejkenHoe B KJ1HHHKY .nexap-
CTBeHHOe cpeAcTHo, c.neilyeT 06Y1IHTb (1)apma-
Konormu Aamioro npenapaTa, 6moxilmm4 o6-
mena coemmem45I H npann.mbHoPi onenxe
CTaTHCTIVIeCKHX aaHHblX.
4. ,I.ja.nbnernuHm HeTkocTantom npemoinx 14C-
ciejloBaH1411 CLIHTaurcH HeTIOBOJMHO TecHaH
CBH3b H KOHTaKT mewAy rIpaKTHKYIOLLIHMH
Hpatiamm H COTpY,IIHI4KaMH TeopentiecKnx
3aneAeHmi.
Flo MHeHHIO AOKJIa,11514KOB sukonneTnopeHne
3TI4X Tpe6onaHmil, xopomo H3BeCTHbIX cne-
nHanncTam, B 3Hatme.abHog mepe o6.nertia.no
H YCKOp5IJI0 6b1 11paBI4J1bHY10 011eHKY HOBO-
BBe,11,eHHbIX B IlpaKTI4KY J1eKapCTBeIlHbIX
cpeAcTe.
114
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
61
113 Tepaneemwtemou KA1111111{12 Meduquuma cucademuu 6
e. Marde6ypee, rpn
(DapmaKonornvecane H ainningecxne
)10BaHHf1 C npenapaTom KOHBaJIJIaTOKCOJI
B. cDEPCTEP
3KcnepHmenTanbHuti npeileapHTenbHbirt BbI-
6op HOBIDIX cepAelmbia TRIOKO3H)=1,0B AMR 1KHO
cikenaTb BbIBOTI,OB. Ha OCHOBaH1414 cpaHHH-
TellbHbIX 14CrIbITaHHil CO crpo(paHTHHom-G,
KOHBallnaTOKCOJIOM 14 KOH13aJIJIaTOKCHHOM Ha
113or1woHaHHom npenapaTe nopaweHHoro
npeAcepAHH M0pCKOR CBEHKH npeAnonara-
J10C1), 1-1TO B KJIHHHIleCKOM OTHOIlleHHH KOH-
BaJIJIOTOKCOJI Ao.rnicen 6b1 AOCT14THYTb 11011H0r1
3C14eKTI4B HOCTH cTpoctiaHTHHa-G. FlpH pa3-
HbIX KIIHHHKaX o6a TJHOK0314L1a 6b1J1I4
110ABepNeHb1 CpaBHHTBJ1bHOMY 14C11131TaHHIO
H kwonHoti cnenoii npo6e, npwiem o6HapywH-
Hanacb ommaKoHaR fundkupiecKaH 30ex-
THBHOCTb HCK11101-1eHHCM He3HatliiTelIbHbIX
paexo>KAeHmti).
115
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
1A-RDP80-00247A002000030001-4
62
113 14Hcmumyma OalintaKo3ozuu Meduqunocou arcade.tuni
z. Mazdeoypze, F,aP
Ytier cnoco6os KHHHHINCKOTO npHMeHeHHH
HH (1)apmaKoaortivecKom NCH bITHHHH
iie-
KCTB
X. MATMEC
YCIleX KJIHHIV-IeCKOTO FICI1b1Ta111451 H pewa-
'omen" eTeneHm 3aBHCHT OT 11114p0Tbl H
iene-
COO6pa3HOCTM npoHelleHHhix cpapmamonorn-
qeCKI4X HCCI1eA0BaHlirf. OAHaKo, npnmeHme-
mbie Ao CHX flop (papmaKonornnecKne meToabr
He Hcerita npncnoco6neum i?)>KI4JaeNIOMY
116
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
KJ1141-114 tleCKOMY HCHOJI630BaHH/O. no npm-
mepy mcnbrrampl r0,11,p33HHOBbIX flpoi13BoJ-
HbIX MAO) TIOKJIdAtIHK AoKa-
3hiBaer, nnejleHme oa,HottpaTHoil 6o1bmori
;loaf:A He noanonsieT onpeae.rum Bee acnetabi
YINI no OTHOL11611H10 AerICTBMS1 Ha MAO, un no
OTH011leHHIO mameHeHng coasep>tK14TeJ1bH0 AelICTBYIOT Ha Ha-
pYWeHHblri mem6paimbd1 110TeHI114aJI, Ha
3nemTpomexampiecKoe conpnweHHe H cno-
CO6CTBY}OT CI4HTe3Y HbicoKo3HepreTHgecKmx
cDOCINTHbIX CBsneH.
119
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
;IA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
3A-RDP80-00247A002000030001-4
64
ha Ilcuxuampuvecgoei IC.1141111KII Sydanettimorneo AM)111411110(0.W
piusepcumema
011bIT noixuaTonecKoro npri-
meHeHno xnoprimpaTa (OeHHJI-H3011p011H11-
MeTHn-np01114H14.11aMilua
9. BAPrA
B pe3Y-IbTaTe (1)a pa K0.1101104eCK14 X HCCJIC-
,11,0BaHl4r1 CTa.110 143BeCT110, L1TO HbulleYKa3au-
Hoe coeimeHrte cotieTaeT B cede noitae.rin-
lomee m0H0amHHOO1KHBOTHb1X coeywHeHHe
?R-1743" OKa3aJI0Cb 344eKTH3HbIM H llpe3-
BbItlar1H0 yA06H0 npHmemimbim nwrocTaTH-
geamm cpeAcTHom H 1103TOMY ero HcribiTaHHe
B KatiecTBe npoTHHoonyxoneHoro XHMHOTe-
panewnviecKoro neKapcTHa Ansi tienoseka
CLIHTaJI0Cb 060CHOBa11HbIM 14 HHTepecHum.
B neprthix KJIHHIPleCKHX 011bITaX ripm 3J10Ka-
lleCTBeHHbIX 01-1YX0J151X HeCOMIleHHbIrl LO4T0-
CTaTHileCKHi1 3414eKT 6b1J1 o6HapyweH npH
pa3Hoo6pa3Hux Hnaax OHYX0J114.
Ha 6.moTta.nacb 6e3YCJI0BHO nyinHan remaTo-
J101"HtleCK3H nepellocHmocTb 110 cparmanno
C 06b1i1Hb1M14 I4HTOCTaTIPleCKI4MH HeinecTsamm.
,Ltono.nHeHme Rypca AegeHnn ApYcHMH XI4MHO-
Tepanewnitieummll cpeAcTsamm oKaaa.noch
HHTepecHbim 14 H3YllaeTC51 icanbwe.
UeJlblo KOM6HHaTHBH0r0 lIetleHHS1 51BJI1eTCS4
BKJI104eHHe BO Hcex cnyganx, ecru! 3T0 1303-
MMHG, XHOYptHileCKOrl 11J114 pamtoTepanHH.
122
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
66
113 neeponoeutteacozo ducnattcepa o6nacmnoti 6onbnuubt 1114.
3emmenbeetica 6 z. Sydaneuime
MeToA HCBMTBIIHR Amianuivecmoro pncosa-
HHfl B CB)13H C npnmeHeintem notxmonmax
neKaPCTB
H. XA13,1114
B 1956 roAy MM atiaim pa3pa6aTbmaTb
meTop, HerIbITaH1451 AviHamwiecKoro plICOBaHHR
B CB51314 c ripmmeHaillem wiewrpoinoKa, Cc-
pl4r1Hb1M14 CpaBHHTellbHb1MH HCCJICA0BaH14ilM11
pl4C0BaHH5l 14 rJ4cam4H. Flpm Rypcax netieHH9
ITCHX0Tp01111b1Mil cpeAcTsamH B HacTogulee
123
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
npeAtH 60.11bHble ,11,0J1>KHbl 14306pa3HTb
neqeciani o6pa3 Ao Haqana, B TegeHme 14 no
OK01411a11111/1 KYpca negeHHH. IlpH 3TOM Mbl
Ha6n10Aaem KaTeropHH H3meneHal : v'roi-nie-
Hife AHHHH, cpopmeHHoe, coAepwa-
TenbHoe o6orameHHe B cnyqae YJIYLH11eHHft
(145114 HOT14B0HOJ1O>F(HO B cnyqae yxynoe-
HMI) COCTORHHH 60J1bH0r0. MHMI4Ka 14306pa-
)tKHbl nonpo6Ho 03HaKOMI4TbC1 C Oa/mato-
zenemuxou, Oapmalcome3aypu3mom H c na-
mo0apmaxam2ueti, KoTopme 06135ICHHIOTCH,
60J1bIllerl qacTbio, meTa60nmecKHmH, B TOM
tmcne 3H314MaTiltleCKI4MH paanHtummil.
06 3TOM XOTH H He Hcliepnbmaioulem, HO Hee-
TaKH Heo6xoaHmom HanominiaHHH HeJ1b351
3a6mHaTb npoicke gem, Kai< npmcninHTb
H3YHeHHIO 3Kc11epHmeHTanbHb1x 143HHblX.
131
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
71
143 CP/111131.1aMplaeCK017 K411/1111111 Bydanemmowzo. eduipm-
CH020 plueepcumema
CnnpomeTpagecKne HCCJIejtOBEIHHR H alman3
ra3OB HpOBH B CBR3H C npnmenenaem npena-
paTa Kaplan
H. XYTALU
1414IlepBeHTHA1IA4OHHbIrl Melo' npenapaTa
KapHOH 113Y4aJIC5 Y 3.A0p0BbIX JIMA H Y 60J1b-
HblX, eTpa,aaionwx tiacTntmoii HJ1H 110.3110r1
cepAelmo-AbixaTe.abnai HeAOCTaTO,IHOCTb10,
Bbl3BaHHOt1 3aTpy,affennsim.14 Abucam4R. FlpH
MeAJleHHOM BHYTpHBeHHOM nne,riennn npena-
132
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
paTa neroi-maH BeHTHJIHWI yoe.an4HoaeTcH
Ha 40 80%, a B COOTBeTCTBHH C 3THIV1 YA/LeHb-
thaeTcR coAep>itamie CO2 H anbneonsipHom
B03,11,YXe H AaBneHlle CO2 B apTepHaribHoil
B cnytme BAb1XaHH5i KOMHaTHOTO
BO3AYxa HaCIA11,eHHOCTb micsiopoppm HOBL1-
umeTc9 H meHbuieR mepe ; og,HaKo, ecinf npn-
meHeymem 6pollxopacumpwrenert (13 BHAe
a3poconH) AbucaTe.nuag pa6oTa ob.nerqa-
eTCR, TO HaCbilgeHHOCTb nornawaeTcH 6o.nee
HbipaweHHo. FlpH BAblXaHHH ra3OBOri cmecH
C BIACOKHM coAepwaHmem KmcnopoAa 1-CapHoH
TOpM03HT AenpeccHHHoe AericTBHe KHCI10-
pop,a H, criegonaTenbHo, anbneonHpHaH Beff-
THARLI,H51 He cHmKaeTcsi. C YlleTOM BUHR-
H3110)KeHHOTO, KapHoH cAmTaeTcH npHroA-
HUM K AJIHTellbHOMY nelieHmo aJIbBe0J1flpHOrl
rHnoneHTH.runAHH, conponowAaiouiert xporm-
ileCKY}0 HeAOCTaTOIIHOCTb AblXaHHH. B 110.11b3Y
npenapaTa roHopHT Aamee xopowaH ero
nepeHocHmocTb H OTCYTCTBHe HerlpHRTHIAX
60qHMX HBIleHIHA.
133
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
.":1A-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
DIA-RDP80-00247A002000030001-4
72
113 mepaneemugeacom omdeizemusi Meduclunotozo ynueepcumema
6 2. 61,u6ade6bg5uu, CILIA
06 yCTBHOBBefilill 011bITOB B 06JIBCTH
mixo-qapmaKonormi
H. 3. CHTJIEP
3aiLatia lommixo-cpapmaKonora 3alunotiaeTc5i
B 06CYKileHHH neKapcTs Ha OCHOBaHHH FIX
mexamnma AeRcTimm, TepanewmtiecRoro 34)-
cpexTa H ToKcHtlecxmx Ae6CTB1411 Y tienoBeKa.
BbMOJIHeHHH 3T0T0 3aAaHH54 KJIHHHKO-
(papmaKonorY rIpHX0AHTCH o6.naAaTb
pa3HbIX
134
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
Declassified in Part - Sanitized Copy Approved for Release 2013/11/26:
CIA-RDP80-00247A002000030001-4
1-0HHHtiecKag oneHKa neKapcneHmax
cpeAcTs_ Hp0H3B0,11,14TC1 B C.TheAY101.1114X Tpex
(1m3ax :
1. FloTtpo6Hoe H3ylleHme cDapmaKoAHHammxH.
2. 3KcnnopaTHHHoe onpeAeneHHe 6Honorm-
14eCK011 aKTHBHOCTH.
3. I1poAon>104Te.abHoe Ha6mAeHHe o6ineti
npHrognocTH H 6e3onacHocTH ripm ItanbHen-
mem npHmeHeHHH.
Xopoun4x HallaJlbHbIX (1)apmaKonorw-iecKHx
HCCJI0,0BaHHA Hmtiem Hellb3H 3aMeHHTb.
C.HowHeilume CTaTHCTHKH He 3ameHi1oT Tina-
TenbHbIX Ha6J1IOAeHHil, 061.eKTHBHbIX npo6
H pa3YMHbIX BbIBOA0B.
B (1)a3ax 1 H. 2 tipe3mepHo HerH6KaH o6cTa-
HOBKa 011bITOB HHorAa mewae cnexam HC-
cfleaonanna ; omiaxo, B 4)a3e 3 06513aTenbHO
HpHX0j1HTC1 cTporo npHAep>i