PROJECT MKULTRA, SUBPROJECT 22 (W/ATTACHMENTS)

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00693614
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 4
• Document Creation Date: January 23, 2025
• Document Release Date: February 12, 2002
• Publication Date: December 5, 1956

,
Downgraded to: tim ERIK
by authority of:
date: June 1977 414
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E2 IMFDET; CL BY
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DRAFT
5 Derse3.-[:':her 1956
MEMORANDUM FOR: THE. RECORD
SUBJECT: Project MKULTRA, Subproject 22-
1. The purpose of this project is to provide funds to carry out
the isolation and characterization of the intoxicating substances present
in certain varieties of Rivea corymbosa.
� 2, has conducted studies
on this material which have lead to the development of methods which
can now be applied to large samples of seed, thereby allowing the
production of sufficient quantities of the active materials for definitive
biological testing and characterization. TMMIlhas submitted the
attached proposal to carry out this work as directed by TSS/
3. The GeschiCkter Fund for Medical Research, Inc., will
.serye as cutout for transfer of funds to the investipatc.)r. The esti-
mated cost of the work is $5,950.00 for one year. ro this must be
.added a four percent service charge fdr the Geschickter Fund, amount-
ing to $238.00. Therefore, the total cost of this investigation for one
year will not exceed $6,188.00.
�
. In accordance with the Memorandum of Understanding with.
the University shall retain title to any permanent equip-
ment tn lieu of higher overhead rates'.
� 5. The Geschickter Fund has made arrangements for the re-
turn of unexpended monies received under a grant from the Fund and
also has requested that the University submit to it a summary account-
ing for all monies.received therefrom.
6. It has been mutually agreed that documentation and account-
ing for travel expenses under the grant which are reimbursable by the
University shall conform with the accepted practices ot that
institution.
Downgraded to: CONFI' 'TIAL
by authority of:
date: June 1977
�2 IME5ET; CL BY
APPROVED FOR RELEASE
DATE:JAN 2002
bulin num.
-by authority of:
date: June 1977 '
E2 IiRDET ; CL BY
- 2-
7. holds a covert clearance.under Project MKITLT.RA
and has agreed to comply with the terms of the Memorandum of
Agreement.
Attachment:
Proposal
APPROVED FOR OBLIGATION
OF FUNDS:
� 1111.1re-
search Director
Date: 7 KA
Distribution:
Original only
Dornzraded to: COMB TIAL
1 by authority of:
date: June 1977
E2 IMPDET ; CL BY)
474
Chief, Branch II
TSSP Division
Approved:
ney Gottlieb
Chief
TSS/
Division
APPROVED FOR RELEASE
� AATEJAH-2-002-
Request-for renewal of support for the project:
Investigation of the seed of Rivea Corymbosa(oloiuqui).
Summary of work, November 1, 1955 - September 25, 1956:
Physical examination of the seed used in this work
reveals that two "types" have been under investigation.
Taxonomically all the seed have been called Rivea Corymbosa
although one variety (the seed are the largeF�Er�he two
varieties) originated in Mexico and one variety originated
in Cuba. The literature on the subject of ololiuqui, as
far as I can ascertain indicates that its use as a psychic
drug has been restricted to Mexico. This data alone would
indicate the probability that the Cuban variety lacks
some physiologically active component which the Mexican
variety contains. Experimental work in this laboratory
has been largely restricted to the Cuban variety (small
seed since only a Very small amount of the Mexican variety
has been available. The chemical work, although not
designed to compare the. composition of the two varieties,
has indicated some difference in the two. Also physiological
tests on humans are Indicative of a difference in the two
varieties. This work is much too inconclusive to be .much
more than speculation at this time.
In addition to the isolation of glucose and hydro-
quinone as constituents of ololiuqui as reported in the
last progress report, two crystalline fractions have been
isolated which seem neither to be alkaloid or glycoside.
Due to the small quantity of seed available the amount
of these crystalline fractions is extremely small And
little more than qualitative tests have been made on them.
Experimental techniques, especially in extraction and
separation, have been perfected which will be used to
isolate pure components of the drug which, just today,
has become available in Sufficient quantity to make the
investigation profitable.'
Plans for future investigation:
Now that 50 pounds of the Cuban variety and 10 pounds
Of the Mexican variety are available, the following lines of
investigation will be actively pursued.
1. Determine conclusively if there is a Chemical
difference in the two varieties of Seed.
2. Obtain as many "pure" components from'each variety,
� using previously perfected techniques, as is possible.
3. Submit for physiological testing each "pure"
component.
4. Subject each "pure" component to Chemical examination
�'4'determine the type of compound, whether it is a
khown compound and its chemical composition if it
is a new compound.
WARNING NOTICE
APPROVED FOR RELEASE
DATE:JAN 2002
SENSITIVE INTELLIGENCE
SOURCES AND METHODS INVOLVED
Proposed budget, November.1, 1956 - November 1, 1957.
Equipment (including larger.scale
extraction and separation equipment)
and special chemicals
Woo.00
Analyses and tests 350.b0
Travel expenses . 500..00
Salaries (one graduate assistant, laboratory
help and director's stipend) ... 4000.00
Miscellaneous
WARNING NOTICE
�
Total $5950.00
SENSITIVE INTELLIGENCE
SOURCES AND METHODS INVOLVED
APPROVED FOR RELEASE
- DATE:JAN 2002