HYPOSPRAY, AMPULES, ETC. (BLUEBIRD) WITH THREE ATTACHMENTS

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00144924
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 5
• Document Creation Date: November 22, 2024
• Document Release Date: January 15, 1983
• Publication Date: February 21, 1951

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; � *S:AP.IIVIND I CIIM NO. CI
Office _Memorandum �
5
:UNITED STATES GOVERNMENT
'TO DATE: 21 February 1951
Through:
FR024
SUBJECT: Hyrospray, ampules, etc. (Bluebird)
Beierence is made to our recent conversations regarding the hypospray
instreinents and various types of ampules that can be made for use in the
instrument.
Iihe "3" team has given considerable thouent to the possible uses of
hyTospray and all concerned are agreed that this instrument (or variations
thereof) would be of extrene value in certain operations. There are, however,
many questions that arise and require answers in this connection. The nest
obvious are set out belonn
1. The rt.:ruler comnercial FTPOSFRAY discharges a Ice anpule. Is
this the only size hypospray made or developed commerci-aly or
experimentally? A 3cc or even a 2cc, if workable and clinically
sound, uJ.d, it is belidved, be of greater use to us than a lec
instrnnent. Full details are needed including all known tests.
2. Very little is known about the various types of ampules used in
or made for the hypospray (commercial or exzerinental). We would
like to obtain all available information in this conn.ntinn.
3. Also in connection with (2) above, ne.woUld like to knew that
concentrations of liquids and solids, types of liquids and solids
have been tested in the hypospray and with that results.
4. 7e would like to knOvrif the standard lee hypospray is made or
has been made in any other form, shape,. size, or reicht. The
standard hypospray is quite heavy and a lighter, nore easily
carried model wnuld be of great help. Also, has an instrament
been built having adoublebarrel and capable of firing two
ampules simultaneously?
S. The hypospray nms invented or developed by James rcKibbin
an officer of the R. P. Scherer Corn. of Zetroit, nichigan..
3oth !:c:".ibbin and 11777-Ycherer are highly regarded and
reputable individuals according to I&SS confidential information.
Ze would ii;:e to known if possible, that experinental nork these
individuals (or the R. P. Scherer Corp.):havedoneen the hypo-.,--
spray or similar instrunents and the ampules that thr� 1:avc nzsa
and tested. Tal =nuld like to kmew if the R. P. rr. ..:077. is
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still nnO.ina 7pules for the hypoepray, althounn the rithts to
the instrument rry,==nt:In ...0111 to the E. R. Squibb
Company, nrooayn, l!eerlerk.
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6. Since all rights to the hypospray are now owned by th� o E. R.
. Squibb Company, Brooklyn, liew York, we rould like to know if
Squibb is nanufacturing the hypo spray now; chat, if any testing
or new developments they have made on the hypotpray; aro they
.making their on ampules and if so at sizes, types, solutions,
contents they are using. vre should also like to know how we can
� make immediate purchase ofhypospray instruments and arapules
(see following).
7. 17e. tould also like to ;-:nao tho names of indiviiluals (doctors,
technicians, experimentors) who have worked on or used the
lupospray and what tests (and results) have been made by
these persons. Further, if any institutions, hospitals,
clinics, etc., have made extensi7e use of the instrument we
should like to know their names.
Based on "B" experience and research to date, this office would like
to secure immediately via direct purchase or by contract arrangement six (6)
of the standard commercial HYPOSPRAY instruments. In addition, arrangements
should be made for the manufacture and purchase of the following ampules for
the above instrument:
300 sodium amytal (ono train each)
100 caffeine sodium-enzoate (two orains each)
. 100 caffeine sodium (ae7en and onr.-half..;rains each)
It is believed that the Squibb Company would be the only present source of
hyrospray instruments,- however, ampules can probably be purchased from both
Squibb and R. P. Scherer Corp., at Det-oit, lachican.
In the event; it is felt that these items rould be difficult or slow
to obtain throuch normal Agency cht=els, this office believes that they could
be Iurchasod kmxosideragaweillegt directly.
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Subject: HYPOSPRAY
Additional information concerning the use of the hypospray
instrument is requested as follows:
1. The hypospray instrument, as presently designed, dis-
charges a lcc ampule. Has any experimentation been carried out
or has an instrument been developed which would permit the use
of a Zcc ampule or even a 3cc ampule?
Z. The present hypospray instrument is quite heavy in
weight. Have other models been developed using lighter metals
which permit an easier handling and carrying of the instrument?
Also *nas an instrurnent been developed utilizing a double barrel
and capable of firing two ampules simultaneously?
3. Are there available any reports on the use of the hypo-
spray with results of research o.n the effects of various drugs and
serums utiliied in the hypospray?
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Any information on the above would be appreciated.
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Subject: Hypospray
Request that arrangements .be made for procurement of
the following supply of ampules for use in a hypospray instrument:
300 ampules sodium amytal (one grain each)
100 ampules caffeine sodium-benzoate (two grains each)
. 100 ampules caffeine sodium (seven and one-half grains each).
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Army Perfectirig 'Gun' � -
For Painless Inoculations �
'Advantages of New Method
Obvious in Wartime � . �
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Syr:amps R. Henry
A *shot' gun by which large groue
of people&ean ha ir.oculatid atileklaj and
: pairtleasly Is being perfected at theAznair
.red1caI errate Graduate Schaal here.
By mans ef it rAccIces aniiikaties
or morph:rig are shot against tits &An
; under Welt preesure. � � �
Its advantaaes would be obvious with
any threat of biological warfare when
it might tc necessary to inoculate an � �
entire population. It Rho. Array doctors
wouid serve well in the case of
troops ordered sudderila overseas.
With a hypodermic r.eedle it is neces-
sera to Ali and eteriNee after each in-
jection. a -time-earrturainz process: lase
. of the needle always is romerahat pain-
ful and many persons have a great
psyche:ca.:cal dread of It.
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The new m:thod reezats to need:e.
It Is absciate:y painless. The ser.satien.
IS no different f:ens that canted by r.
rater spray under hilh pressure.
' Method Avoids Infection.
Other Lateorteat advantaaes painted
cut are:
With. hypodermic needles there is �
some danger of tram:raining La-feet:on.
such as 5:frilM3. realOri I Or :re r� 0 'V
jaundice. This is csacaially trae when � .
Large numbers eaust be treated In. a
hmay.
Since thee is no penetration of the
shin. except Ly tile vacctr.e Itself, ao
sterzation is needed. Practically no.
sxaerience or tra'aing is necessary. arse
3: the needle is a Jab Zr a doctor or
_rained technicir.n. This -a ould be very
ine.ortant in rreeh an :vie:acme; as a
:tau bacibing. .
When produced in quantities, jet-In-
sctfan apparatus will be relatively In-
xeeraive. �
There is occasional failure of the jet
aarateate the akin of persons with
Irtlealarly thick hides or with thick
:aubber.' .4 central that will enable -
�.e oaetater to vary the preasure ac-
.riang to the irailvidual Is bean; worked
:t. �
Tne methed Is worthless for any but
aeaftaz Cr ta.e :Ain. It cannat
used far taatca:ors iraa tl�e
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� A new antibiotic active against
amoebae in dilutions as great as one irr �
130 million has been reported to the �
American Association for the Advance- �
merit of Science.
It is extracted from a species of mould.
aeracillin. The new sultztance, de-
.
, acribed by Dr. atax C: eCowen and
� his associates Of the Lilly Research
.1 Laboratories at Indianapolis, appears to
i be the most patent agent yet found
against the microscopic animals re-
, S saansible for amoebic de:Wary and
at**
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Jet Injections have been In 'use:but-77�.1
on a very limited scale, for some years. �
The Army's apparatus is a great im-
provement over any used in the past. 1
. Discovery of the method is believed tea--0!
. have come from observations of auto- �
mobile aubeing forced through the
� skin of mechanics. It also was noted
that line jets of oil at high velocity.
as from a leaking hydraulic line, could
penetrate human skirt and leave little
or no mark.
The apparatus. It is emphasized. atia
. is In the exne, rino.ental stage and will
not be used for some time.
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� many other Maladies."
I . New Amoebic .Arillbiolle.
, The new antibiotic. called funtazillin.
vents to be sPecille against amoebae.
7asts show that t r.tty has little
; � e�rect against other =acre-tn.:antra-4
, such as bacteria. fungi or viruses. It
Is the first substance yet found which
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� seems to be specific aaainzt craozbae.
i Even in crude form It is effective. in
� lahaaalory teats with :nit-anis. In
tiaras as high as cne part to le million.
�, The principal tests to date have been
with experimental infections with cab-
4, bits. It was found. according to Dr.
� McCaw= ar.d his associates. that the
animals Could be completely cured by
:1 the iniercecopic organism in four cll-
.!! sided doses administered over two days.
:1 Less than 100 milliararas per kficeratat
of body weight was administered. Quite :
� similar results have been- brouahe about
: With young rats. .
:� Tests with hnmans. where aracebia
diseases such as dysentery are likely
.to be very serious, await further ex-
pert:nen; s with animals. Maladies
� caused by thrne organisms are 11:aly
� to be extremely serious and aemetimes
� tend to run In taidcinics. The bacteri-
� elf:lists mph:lain that their report is
en'!:',�!�1 aa
eza a at ���auld
have ectrintental effects on humans.
Teal have .dfanenstrated that it haa
'no effect on i:rata in mice. �
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