MKULTRA SUBPROJECT 8 (15 DOCUMENTS WITH PUBDATES FROM 530609 TO 550728 )

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00017481
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U
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36
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September 25, 2024
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September 8, 1976
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June 9, 1953
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MKULTRA _ Sub_projeet .; ;i scription mate ',I Obligations Expenditures Balance i � . - sr .- i/1114d ; - . :44/ 07.9d 00 1 11 '� ;19:A.P1.0 414* I t _ I ,IIIt _ _ / f3 01. ,c1 ,F4 0 0o , � it� . 4,0 0 .0.0 � , , ! , it 2 It 1r 1 I 1 ; I I t; ! _13 r r . --H 3� I- ; _ ; .--;;1- -,. � i I I : i �1 :. ". ' � 1;111i ., � - r.! --t -I- ;- ; 1- ' - ill 11 -,,, ! 111. � t i ; _,.i I I: it i't1.1.! PEMORANDUM FOR: SUE RECORD SUBJECT: 28 July 1955 ADDENDUM TO SUWOJECTS 8110 1. The purpose of this addendum is to set forth the mutual administrative responsibilities of the contractor am& sponsor. 2. The abovesubprojectsrepresent the research program Er, of located at the Boston, I, tslcovering-the-peri 1, Septembet_1955.- 3. The as requested the Hospital to submit Ito them a-summary'accounting of monies received, from the Fund. Alac--tbey-requested-the return of_anyUnexpended funds received under a. grant -from the 4. Title to-any permanent equipment purchased by funds - granted the Hospital shall-be retained, by the Hospital in-lieu of _ higher overhead rates. 5. It was mutually _agreed that documentation and_accovnting for travel expenSes which ate-reimbursable by the 44011WHospital shall-conform with the accepted practices-of that - Institution. 6. It was_agreed_that technicalreports_refIecting the _ progress of the research prowm shall be submitted at mutually acceptable intervals. soosix -Distribution: � Orig. ee. 2 - TSS/CD SIDNEY GOTTLIEB Chief TSS/Chemical Division APPROVED: - 177.7777- --mom .1 oom 2409 - � _tho f911O4riz otatement:----- "Thid�-��:: - vill not bo73. us,l-fo-r-drut - purposga ora-ol.fl by- �13 for su-zii u4e."-- - XXI-ZOMOLNX..1P-747114 70,7LIMS *747.:C�st ew ww-www seww.wwer,^r.'w,,W"'''.'""fw � A CERTIFICATE March 2, 195 This is to certify that I have today Cashier's cheek No. M1.38328 of the INS in the amount of $26,333.33. March 2, 1954 This is to certify that Ihave today received. Cashier's cheek No 14138329 of th in the tesolmt of $526-.67. TO: FROM: SUBJECT: MEMORANDUM RECEIPT I hereby acknowledge receipt of-the-,:foil ig CHECKO,5" RECEIVEDIN . T, . r-sE AMOUNT OF_ $.:V.r13. 5.1 CHECKr527 IN THE RECEIVrc,. E AMn' / FEB i 8_1954 - ----------------______ 1 FE81 0 Please return si pod copy fasr Of- th-Vo�re�ce 0 -/.9C4 To FORM NO. 36.68 MAR 1944 - S PUTURE OF RECIPIENT DATE RECEIVED f 111111l9P1W 11����1, NEMMUTANroc OW, FIUN VIA: 4bu44t Wyteer =Mr: � 5 Vibruary Invoice Z, Subproject Drioice 7o. for Subprolect 8 of Project tri21,f,VA � . � tacbed rece-,atoti. that ..p;�,1-,t- be.m1c 14_ .thiin .-thia an:Arita' of VLIC;i333.33-ar4 13.36.67 m.,63 Out to -.11174 checkajr..boUla bee-:-,st=rit .CD/=1,- throu4,11:735/111-*:tot-r--- ., =core- Att.lalmmtu: Invoice Certlfioatloos. - AdJxs.auco 1 Couz4roller 1-- - F.zteo, � vn - 2 ig321 Ck&lNThE1 AMOUNT 07 $ pEcEivrED,. � . cr.d.047- FEB 1.8 nq , 47, IT ..� (1) it la hereby cartirSol tbett title Is LIVCddes rp� 2 applyirq to etibproJect 3 ot ?tolest 2:-.1t,Zati that tochr.ir:O1 rerformrsoo is ciatie:ortory, U. tba liork1i L1 CV",11-31-44 I- � CiartiaiSd* vita tl:a mutual a,;roment zta,thei, vith that a, _ Clio bill ia jwt nal correct ami that parilz-at taoreol) hos tot -et Ufa Lvtle� (2) ."1:t is llofreb7 tl=t thin itivoi appl...5.03 toettbproYezt. 8 1W:or Proloct v",:achivs,a caly t,haz tto EiroJoct 13 '01424 VIA'Titti out, irt acl.oraz.zoo with tzt.;0 Doi? mr-lotrottliza to Wi eatol Inotva-tradva to SIVA 4Catod, 13 .P3ri1. 1953. Ez,:fritalt Lu outaoria�ol rovaatoA� .� (3) it la heray oArtlfitSi_tbat_the of tj prograu ot sub. project: a or Projtot b,o..3-boan cpproved� I MRTiFY_ZIAT_F-L.:::T.-t7 -AP.0 A VAM;.131,Ef � � � .; mloArcir.4- � .7 0 AU C.fiTiCeti. $26,333=33 tx**526.67 . 0261860.00 ' Payment due for grant t Service charge of 2% for C. (41-: TOTAL Apgust 31, 1953 This is to certify that I haVe todsy reciived 1;u:bier's check !lc. 2.2.33785 of the .in the amount 61"-013,16667. August 31, 1953 `;-� trnis is tCL certify that-today I ve received Cashier's check to 337$6 of the in the amount of iir263.33. TO: if _ FROM: Budzat Offices TS$ SUBJECT: Two checks I hereby ae4now1edge receipt of the following: Check if M133786 in the amount of $263.33 and check if P133785 in the amount of 0.3,166.67 as MMent-for invoice # 1, SubproJeot 8 Projeft MKULTRA. -"� Please return To signed coig(ies) of this receipt FORM NO. MAR 1949 35-65 ' MEMORANDUM RECEIPT TO: ptilim: Budget Office, TSS SUBJECT: Two checks I hereby acknowledge-receipt-of the following: Check # M133786 in-the-amount-of 3263.33 and check if M133785 ia the amount of $13,166.67 as Payment for invoice # 1, Subproject 8 Projeet I DATE RIDE,34D 28 August 1953 DATE Please returt sigmad copyilas) of this receipt To FORM NO. IllAS 14AS 14�11,103.141Caii 1't.t C MIT) FLLIXS VIM t.7.13 .717C1): � itWzet Officer DIVOICO Ndo 1 for SaprOleet 0 0r PrOjeet WU= le attac It . TA.31t1 tilet r� at be mele.by_tve cLoc%e_in ameunta of. 413,166�67 and 4,63,33 rade Out to 111'01100174-3110e14- 01) -'Attacbroete:' raveled OertifIcattml )it ribution: Aitlreaf;o0 Cocntrallev - 1 �����,} WIMPRZW!TIMI 4.4 (1) � 7/t 10 licroby cortifiaa _the.t this to InvoiceNo. 1.eon ng to subproject 8 of Project MUL71., Pk, that tcebnical terformance brie** te entioracto/7, that 'the work Is bcAni.7, sl000maislici in- orLa vith the matual ezrcement -reached that: this- bill to just ani correct arel that pay= yet boon =de. , � (2) It Is hereby certified that this invoice ariplioo to sql.vroject . - 8 unier Project 11-MMA. which -Vas ;lay al3provei cal& that the �eroject is beim carried out in secordance_vith the Ink re`2�120raMitZ to WI date-3. 3 April 1933 caa the =1.* metal-a/13ln to DiVA dated 13 April 1953. Pr_vinent is antilorised olva requested. - , 2- � ii y.tes.catircetor (3) It Ii -Inrcoy certifte4 that tha coope oft program of subp1o4eet 8 of Project KCJLarilA has been a.pprowd.� � -2'11 Date:. (2,.� ICZY:41AILn1 Rzrzzaxo-....1 COVZOLLtii � Vinance DiVf21011 SiLISIZT1 Prolect 141.STRA, �-� laqt II-44r ea authority crx-itol in the mit/on-ma= el:44A 13 April 1353 fro1.4 thaZX ItOitto DDA c1 Met further mktbarity p-ant4 the witorczdtla eat.-4. 17 April 1.1:1;33 frC4.1 tit-A DDA to tIO (3042trol-lert On tbe aubjects ttinit?-7:33 Project V-,Xtrail,Vip a'ale,v0ject 3 43 1N-N,t1 .2.221%/VOi 1 -V4iMiC-1-of Via war-al 1--roleat 1-ZULTIt ilunds hue been oblttol to caYar thO aub2ro,j4Wata on.ratrica. tini17111D AQ-3 Iln,=.7440-01 - 1.300 a.vaiwinks.a....mokarft_amnainiel66611 - 4.0or:=4:a Cilairtt-Ans iiji, ' 1.1!)�:, A??1,17t.10 roa onucanou Ca? rals:),',31 - cfl Di�rz.,!:-.1tor � � Dia t"13,MtleAl �, 01.15: � 2,:�2 tj V 1113trif - 2 � JUN 1.9 ENTO 462 Payine.nt Dle! for grant to Service Charge of 2% .. /,'-,b( fir' August 18 1953 � ...... o'yee.v. -- �TOTAL $13,166.67 263.33 a3,430.00 DRWIJONOPM 9 June 1953 MEMORANDUM FOR TEE RECORD . SUBJECT: Project_MXULTRATSubproject 8 1. Subproject 8 is being7set up as a means tocontinue-the nt work in the_general field-et L.S.D. at until 11 September 1954. 7 2. This project will include a-continuation of a study of the biochemical, neurophysiological, sociological,- and clinical psychiatric aspects of L.S.D.� and also a study-of L.S.D. antagonists and drugs related to L.S.D., such as A detailed prouosal is attached.. The principle investigators will-continue to be all of cut-out to the medical budget) The-estimatedbudget of is $39,500.00. The and cover for7this proje research._ kservic is to be paid to the the prolect at will serve as a t-andwill fkitnish the above funds as a philanthropic grant for of 4790.00 WI of_the-estimatea77-- for this service. 43-. B � 4. Thus the total-charges for this project will not,exceed ,440,290.00 for a period enaing September 11, 1954. - 5. . (Director of the hospital) are cleared through TOP SECRET and are aware of the true purpose of the project. _ Chemical Div ion/TSS PROGRAM APPROVED APPROVED FOR OBLIGATION AND BECOME/MED: - OF FUNDS: esea h Date: Attachment: Proposal Original Only. ft -2- search Direc Date: ;11. TU3 FOR CNTINUATIO3 07 iUiW PaGJrAt II CN L.S.D. � d-Ln6110I0 Acro DILIHTLAMIDE TARTRATE. To- includo Study ofit.S.D. Antagonists and Related Drugs Such as L.A.B. � Lysergic Acid . Ethylsmide._ _ The prospectus for next year is in general a con inuation of the ' L.S.D. project aloe() similar lines ta that of this year. .Each aspect of the _ project (biochemical, neurophysiologieal, sociological, clinical psychiatric) � to be continued. The principal addition in the broad arias of study is that of a psycholoFtiCel section which consists of work not outlined in last yoarts_ protocol tut which nevertheless has on during the year and has brought forth aubstantiaL-findinge.gaffi4e4JP.PoiPt eat the necessity both of its continuation rind Each scientificaspeet of the project has led to the develOpment pf Procedures and methode:which are now of proved usefulness -in the study of lysergic and other -similar drug reactions. It is the farther-application:-:--- of the c4thods which have been_developed duriAl#0._P40.YearroLexperlmentation that, will be one of-the'principal-fOcuses ofjlextyyear'ework. Mee rethodewillbo.:applied-tp the study such as L.A.!. and any -other drugs which rake their appoerancei and to the study of other druge in conjunction vithii-sS.D. with the goal of ascertaininz _ antagonistic-effocts. -We would also like to expend the base of the experiment -by applying- these methods to tho study of patients with functional psychoses not _ attributable to drug reactions. This will_not_007_teOt the pplicabiflty of the methods pa a broader bm�is but will deMonstrate-more precisely the - degree to which the findings of the studies of the lysergic psychosis can be applied to understaAding schizophrenia and other functional...psychoses. ' The past yeses research hes dealt to a great extent with determining the syliptoi.s produced by different dosages of L.S.D. and the degree to which theco symptoms can be determined by the social situation in which the subject finds bimeelf and by the basic personality and social attributes of to subject himself. Fdr the study of the Use of other drug in conjunction with L.S.D. to ascertain antagonistic effects it becomes necessari to develop more precise measurements of L.S.D. effect than any wo havo hod heretofore. This constitut63 an tecontielly new field of nrzely that, of develogng- quantitative r:eavarazenta of lysergic effect. From our background of clinical and social observations of tbe a iysergic psychosis tallith havo'been carried on throughout the past year, more precise and objectiNe instruments of7Aessurement-wi1l be devolopod alongithe 1'01"r-1J, lirs. mcasuretants such a polYgraph chanlres and _ _ sensitivity to specifid physical stimuli such as flashing light; sycholelital measurements of persistence, motivation leek, distractibility, mmory, reality perceptioni-richnose-of associations; sociological and social utleallEamtElammti. such as quality and quantity of verbal production in differont structured social tituations_ouch as prebled solvinc group F' discussion and occupational task situations; psychiatric determinations of � mental status (which is essentially a continuation of the present method -of ' clinical evaluation). Fart I. Biochemical Studies_ These studies were carriod out at the -.Directory L.s.r. as a stress agent upon the odsenal cortex. Twelve volunteers were chosen. On the control day, ner ly_ he urinos collected at pre-determined intervals, end at 3.00 o'clock in the afternoon, an injection of ACTU 25 mg., was given to teat the rsponsivity of th adrenal cortex.. The urine was examined as to'volumo; rate per minute; and, chemically, as to the content of Oreatinine (determined in grams per 24 hours); 17-Ketosteroida (determined by loliigram per hour); Sodium (determined by.milliOam_per-hour);_ rotassium (determined by millizma per: hour); Uric Acid (determined bymillitram p&I* minute); Phosphates (determined by rallicram per minute). On the eAperimental day, the-volUnteers-received i.S.D. early in. the morning at -a definite hour. The urine again was collected at exactly the same time intervals as en-tho-centrol dayi- Three central erTerimente were carried-out in which glucose_was given togathsr with L.SsII. - From the data_of the Chemicei-determinations collected, no definite conclusions can be drawn-at the present time. Soma of the results were not- . _ consistent. There seems to have been some technical difficulties, such as errors possibly rade by the subjects themselves with reard to the dtact time, hour end minute, when they discarded the first morning urine, and also possibly coma errors in chemical determinations. Vowever, from the overall picture of the data whic lend themselves-to evaluation, the impression was gained b (L. the as well as by that L.S.D. seems to cause an inhibitory offeet upon tho adrenal cortex. It is felt that it is of utmost importance to continue these chavical &terminations. ,ome slight changes in the technique are contemplated in orderito establish data which will allow a greater consistency, and therefore, batter correlations-. Part It. Antidote Fxpertzento �- A number of antidote experiftents were carried out contenplated for the future. In the course of theee-exporimenta the iepreeSion was pined that the molecular etrucbure of the agent Osed had a definite relationshiewith regard to the effect of 1..8.D. In some intteneess the effect of L.3.0. seemed to have been enhanced, as for inntance the experiments with ergotamina while definite neutralizinj effects with other agents were not yet established. Fart III. Lyrgic Acid Ethvlamide_____ A new drugs-L.4.g., becarts availeble for us and we_prapose to investigate it more thoroughly in the canine, year. Thie drug was developed At the Its mzs in Lysergic Acid EtItyeeide. This chemical ie cloeely related to L.S.D. the difference being msrel,y that one ethyl aouo, 02;15 has be substit-uted by hydrogen (11) atom. From the prelLeirxe. y report of the we learrtad the follovin6 L1429 e.xperimente were carried out on 28 noretal persons and (3CO3 psychotice. --The, drag irg:A$ given in-doses . . of....0.5 to 0.7 mi.1114,,rems by sabcu.taneous iAjectiVii%'With this amount, normal - experienced a schizophrenia-like condition whicli was characterized by adyn,aly, indifferences impaited volition, and phenewena of depersonalization. In sohizophrenida L&E counteracted paranoid belluciratory cacitation. That ie to &ay, the schizophrenics did net lose their paranoid delusions or halltTeinstiona but beeme indifforent to them; a phenomenon which appeared to the investigater es elmilar to the effect of prefrontal lobate., and therercra be eoneidered the effect of LA% as that of a revorsitao Ichtazical loboto .: Oa the Imsis of their observations, the investigators considered_ latl: as a new kind of "sedative"; a sedative which in its effect is neither related to the group of hypnotica and narcotise of the terbituric morphine type, nor to the group of the sympathico- or parasympathicolyti chemicals. The theoretical problem presents itself to the qUastion as to how - it is possible that -a cbemical-Ishichi in nornal people brings about a distntosration into a schisophrenic�like condition; is, on the-otheruband, capable of-tuning down-or neutralizing-the excitation of 0� schizophrenic psychotic. Other problems Presint themselves, the meet Iztertamt of utiCh will - be the intersction of LAE and L.3.D. It is possible to-think that LAE night _ have in antagonisticif net to say an antidotio effect-upon LOX. 'Pat IV. Physiolodcal Studies _ (Combimi Physio-psycho-sociological_studios) - The physiological-changes during a lysergic psychosis ay be explored by. use of the polygraph. Ibis apparatus nakatFit possible to study mar4, physiological parameters-simultancoUsly.--In addition a tape recording of the verbal interchanr40 tetween1the71y3eraized eUbject cavl the examiner Is synchronized with tlee physiological-record.- Socionstrio classification of interactions (Bales interaction -method) is carried out also-by an observer and recorded on the polygraph record. Thus the polycraph procedure-can be used Ito Obtain informatio at the (a) physiological (b) psychological and (c) sociological level - all funneled into one record. Analysis is beinzl d lotod along-the followina limas (1) dl erence _ between tho resting physiological values pre L.14D.-and durinl lysergic psyche 15. (a) Lifterence between stress plwolologisal values pre and durin43. tSa"titaiiat* Two 00,880.3 of stress are used (4) E000/ItiApy physical (ico application A flickering light) and (a) psyc elogical stress (psychiatric interview and specific psychological teat). _ Forther ame/yeis related social classification of vbalitttoni during the psychiatric, interview with physiological factors. The it is possible to deterr.ins -whether pulse, tererature, respiration, GSA, muscle activity, oto.wry as a function of positively oriented social verbalization, negatively oriented verbalite.tion, or rautral. Thie study is done both befor9 and during lysergic psychosis. An interaction chronoaraph ritrot being developed by oz' electrical. - : engineer which will do the followingt (1) Record on polygraph paper when subject is ta.lking and when exaniner is talking. '(2) Accunulate the talking --- tine of each party on an electric deck which-Can be read at desired Jaen-els. (3) Give crude estimate of decibel strength of talking of either _ subject or examiner. During ly-sTergic-psyci.csis it he been noted clinically. that blockina of sT.......cech is one of the earliest signs of lysergic_action. has already been shown that inrbal-productivity drops durincii_the lysergic psychosis. � � Pi.u�ther psyete.)-physiologieal exploration which we think nicht hold promise would be to determine the nature and decree of 'psychological - - stress induced by flickering light in rolation to the disorganizi.ng and ebnormalizing effect of flickering light upon the B.Z.G. It has been observed that a /5 par second low intenoity flicker vrin, produce a feeling of great tension or irritability in one subject whereas-it will to calming and pacifying to another. This study Is also to be done before and during lyseri;ie ps,ychosis. A rivaber of controlled experinents were carried out to test the au on nervous cysttweer the influence of LIS.1).' 'In zone instarices� tolynrephic, electrocncephAogrophi and eleetromdiogrophic tra ' were taken. � The number of experiments is not yet sufficient to enable us to arrive at definite conclusions. Some of the contemplated experiments, for administrative reasons, have not yet been carried out. Tho autonomic nervous system was tested on abjects Who had rec L.S.D. orally, in the amount of one gamma, one-half gamma, end one-quarte gamma por kilogram body weight. The greate'st-runber of_experiments were - carried out on subjects who had receivedmerely-of.4,-quarter gamma per kilogram body weight.. When L.S.D. in the amount of one galma per kilogram 'body.weight was _ given, the injection of Errinephrine, As compared to the control, showed a considerable inhibition. 'When one-quarter emta per kalogm; body welOtt of D. _was given, a nutther of the subjects showed a definite inhibition of the autonomic nervous systen on minimal amounts of Epinephrine and Macholyl. In these instanced, Epinephrine uas given in-the amount Of ,,O cos of 4 solutiOn 1:10002 and Mecho1y1 was given in the amount of 2.5 mg. intrsnuscriciiii- tono�arter of the ordinary amount of 10 Milligrams. As we had-antpated, working with those minimal doses of L.S.D., au well as of.Epinsphrins and - Mectolyl, ro such inhibition was noted in COMO cases. At a recent conference, it was decided that the future experiments Should be oarried out with-1,Din1the-3munt of.onehalf gamme'per� kilogram body weight.- The experiments secnito be pf igniftcance in73sz oh 44 clinically-, auteneLtie disturbances fellOWingtheadministration of 11.S.D. aro usually " observed. ro experiments�or administrative Tema have yet been carried' out with Vague stimulation end adrcno4tic and:vague-bloecin3 agents.- -bymet oda he has 'adapted to lowor vertebrates. Briefly, he adELL aet up (now collaborating with two laboratories to study chronically men patients reeponso to award conditioning in terns-of their ability to Aevelop desired behavlor,and to continuo such behavior over long periods of tirte� behaviordeveloped in humane in-eollaboration.with A. soon as trd.e hIman-laboratory is pot up nd reliable carves of was plan C, to test effect of lysergic acid on tha_bahavior cures. . Part V. Clinical Psychiatric Studies (1) We Will continue-as in the past year to ntake a clinical psychiatric evaluation at the heltbt ofithe reaction of_011 subJeets vho reccive-L.S.D. (2) VS ilirical_paychistrie evaluations of_tho-offcct of , draga in cokbinstion with L.S.D. .The goal in thil aspect ofithaprojectis 4 the evaluation of antagonistiO-Offeet Ideally We-teel-it is-dtairable'to-tsko several exporitenteen'tbe sane subject. For empies subjeCt UIWT.,.c,*P. alone; Objett_Withdrag-L- 'under consideration-alonevaUbjett withioneha/f doses of L.S.j% end.. drUgv subjeet with full doses of L.U.D.-and-dre44,- and probably-- subjectwith-full dose of one and half_dose:otthe othersi This ideal -situation is, however, limited by the desire of the abject to have the experiment rapeated on himself and past experience would indicate that very few -subjects would subait to tote than two or throe tests . during.tho C543 O) a yean-- .11. a result the combinations-of drug and L45.C.- will be decided in echinstanckl_with reference to the avelltibility of the subject and the taximm utaisationof each individual 'experiment. � � �_i (3) We are particularly intsrestod in the psychiattid �ftocto of chemical variants of lyeergic acid of which L.A.G. is presently available. Th le also interest in combinations of,those_chemical variants with other druc, the goal, as in (2) being defined utiostances having antagonistio effects, (4) We have sms interest in the administration of L. D. alone or - in combination with drugs ad other variants of L.S.D. molecule to patients -- with various psyChlatric syndromes. Tho-goal-in this aspoot of the work which has wide reldfications is therapeutic psychiatric effects. The observations here as in the aspects above are in terms of variations in the clinical psychiatric picture. Intensity of SymptomsP-The-nlinical psychiatric pictures are gtaded occoroing to intensity of Gym ma pr departure from normal as mil:4 moderate or severe. The intensity Of individnal symptolts are also graded on - a scale of four � zero being within normal limits and four being the most severe. In certain instances the -departure fromrnormal-is in a negative or - : mime direction as, for example, in the case of hunger uter6 pathological-- absonte of appetite might be rated in terms-or-a mina aigi and pathological� inc:esse in appetite in toms of a plus sign. Integratio4 of clinital psychiatric findings and of finaings . � altered social bellaviox_e. will be further dovolepect.----Only as the change i lynergisod subjectle ability to function in varied social situations is .related to the changes in his mintsl status can the basip&rica of psychoses ba ascertained. Co tar the-abnorpialities dotomined by clinical psychiatric evsluation an those fonn-A in hour-to-hour social observation have to soma extent been viewed indapendently and oxionsiva integrative analysis is required to e E2;11 holoi The drsuLa-person test (D.A.P.) should be continued as a reular part of the psychological program since it now aPPears to be a partionlEtrly fruitful approach in giving leads about the subject's self toncept and his attitudes toward others in an indirect but meaningful way. It might be advisable to add to the more drawing tochnfoue a sat of routine questions.e _ _ aSk the _subject to associate freely to the figure he h'A draun. This would give CORO idea of richness of association in ramrd to people and in rear d to his own creations. The T.A.T. should be continued and possibly enlarged to include ten cards. Intensive analysis of one case has-shown that there has been a decrease in the number of words used when giving a story under L.3.1). in contrast to �the =Taber of words used in the normal -state; the subject also _spent leee-time_ on each picture. Tho riche of association could be investigated mere thoroughly using this projective device by -not oflly counting the words but making an analysis of the skeleton words (nouns end verbs) and descriptive phrases (adjectives and adverbs) in the two states and tho.byrothesis could here .to formulated that under-thelyeergited-ctate the/ Subject would be -less creatively productive and give le-es richaess in his stories. It is suggested -that since only three of the ten'Rorschsch cards are being given and since-the-Rorschach is apparently being used in full by another group, that 144 discontinuo- tho'partiol_Rorschach and work with other types of tests. It is -suggested that_in:Oa. 0-of the Rorschach we use the Vigotsky. The test has, in the literature, tireport of the porformanc of schirophrenics. This is essentially -a tst of abstraction and in the adainistration of it the examiner Can easily insist on or demand verbal reports of tho ideation and the hypothesising-that-is going on while trying to do the teat. � it This particular teat vems to be one which is chaUene to hose people of superior intelligence and is one which also creates-a-somewhat � al stress situation. Because of the foruulation and rejection Of hypotheses which i.e involved in the situation of this test the subject's ability to concentrate and function in a stress situation can be observed. _ Hi� ability to shift his thimking and his ability to respond to the examiner who can increase or decrease -the stress situation by behavior_and_comsents Can alge observed. It seems 83 though this test may provide a greet wealth of material which should allow-for correlation with behavioral obeerVationd- tade in other than the-tosting:situatioh. .I will bo the examineettrelP040ihilUtO4A41.4O:teat to .successfully � be an flarnoyee or successfully keep the subject Working when he �sane:7 longer tolerate the fruatratien_excerionce in itself. Since this is a motor task, discharge of rision-throuth-overectivitv could be observed. Porceptua _ distortions could also baaakedabout after the brat is coropleted be-important to ask at-the end of this test If the_sUbject could.review his -- mental processes on this task which is _intangible:and wherevit--is-ObviousAhat there is a solution and an answer, Whether he blamos. the exaniner for his - difficulty, blames himtelf,'IthevtLwithdraVAI..or hostility in reaponse to- _ . . , stress and co on could bc-ostimated or-evaluated-more-directly. It is suggestelAhat th,aproverbsbetdiscontinued in this new :- experiment. This is ssentiallyAocause:�oLtheLappareint inability of the -present younzer generation-to-deal with proverbs and their qv/trent lack or contact with them in_their everyday liling. Since Abstraction problems can - be dealt with in the Viget4cy both in -a Verbal and'-nen verbal level, it would seen advisable that the remaining time which is probably all that the -psychologist will be given-be-devoted-to-a nore-opecifically perceptUal test ' Guon no the Bender-Onstalt in which the subject is required to reproduce gemetric desicns Beyond to drawing of this test it might be poeeiblo also to use it for riebneas of aseociation in that the subject woald be asked to tell as many things as each design made them think of, or one could see how .any words vas suggested to the subject by the fiven design in one minute of time. .There will be a problea eepeeially with the Vigoteky about .giving the test to the person in the normal state before he has 1114 Lef; Ds sines once this test hoe been solved it is no longer a challenee to any individual. It is suggested that for this test_the-subjects all be given it first while-- i under L.S.D. and th n have-them take it a second tir.o in their normal state at which time intensive Sjnvestiation be made of their feelings, attitudes, reactions, etc. Fart VII. Sociodynamic-atedies: *- Comoarative St.dies:ITsina-theTInterolav Cata,eries as -Basic Tool of Reeiatet 2. _ - . - � Daring the :past year-the-intaplay categories have_teen.applied primarily at a time when-dietortions ocenr.within7the,limit of-noviel - situations met or.soUght:out by the subjeot.- Further extensiontofithe_applicae tion of this method are_to..incltdo sympteem chengoe-ef the-subject as related to interpereonal relationships and Wider:Vatietref7tecial_situations._- Some of the eituatione-imwhieh-ftrther atUdy.ie_indicatedicare: 1. Croup-probleaesoleing-eituatione. LYeergio subjects are , asked to work on problems or social _end ethical nature, and their_generalconduct is to be measured by such instruments as Eales Interaction Proceee Analysis and theInteraCtion Chrenogreph, in addition to the nine interpley categories.- Eubjeote put to bad and given supportive nursing and medical care. 3. tAlbjects engaged in phyp cal and cports activity. In conjtthction with those studies We wl-h to apply the interplay cateEories in a comparative exploration of therapeutic techniques with 1,y3ergizo4 subjects, and normal psychotics. Judgir.g by the rany extant inconclusive and often contradictory reports on psychotherapeutic techniques, intertsive study of the psychethersboutic sitmtion, with the aid of the interplay categories, ia needed. Little 'is known, for exaxple, of how adequately or how dosely t.herapiets elf-e,xpectation about their roles as therapists ere 7:..ett in en actual_thorapeutic into:vie:a'. Moreover, _trith this method, the seqUential_pattern of therapeutic attitudes and verbal conduc can he explored. 2, Comarative Analreis of L.C.D._ond Psychotic Distortions A further-extension-of the =lye's of visuel_distortiens in L.S.D. _ subjects is planned-to include inveatisation of-distortions wbich occur in : psychotic patitulta. rntther investizations scem indicated to determine the similarity, frequency of_ occurrence, and - the conditions. -leading - to and existinz at the time when distortions -cools in psychotics and 1.;S.17.--subjects. Such a study is expected to'lted- to a much needed understanding of :the moaninT = of these distortions to the pationt and tbeir inzportance in psychiatric interpretation and treatment. � 3. Continuation and Extepsiort-of:klthods -of fertenlity Evaluation - The relatedness-profile "see Quarterly- Report a) feeu_see on the - domirAnt kind of rolateineas, the -latellrofpatticipation and the degree of --- (Arose experience in the six "people- areas." _The clinicel -eOcial-t scores the qvality_ ot the 1ndivala Wet-al-relatedness pattern in terms of Ispontanoity vs. control" and so forth (�rterly".Roport a). A report of the use of the profile and clinical &poly&is wlll'appear in the third. quarterly report. Evaluations and ansly-sissdurine, the past year haie boon 1_ a easentially a comparison between the basic personality ent1 the 80ctal. behavior before and at the height of the L S.D. reaction. _Apart from extending this typo of analysis to t3e tot4i. available number of cases, ferther studios of -this nature aro aimed at elucidatine more ------ clearly the Psycho-social alterations of the L.S.D. subjeotts conduct on a chronological hour-by-hour (and perhaps even lainute-by-minate) basis. It 13 expected that this procedure would give a more -intensive dynenic appraisal of the sequence of symptone. The fiharts_fron_the_sppliction of these methods will be integrated both with each other and with clinical and psychological -- findinizs. 4. A Cozfparative Study of the FragMatics, Syntactic s and Semantics in L�S.D.; and Genuine Porchosio In working with L.S.D.itubjecte niicb difficulty has been encountered imattempting to find words which adequately-c=municate the feelings and- experiences of the subject. This 13 equally true with the psychotics. For example, word� such as fttraniii",.nweird41, nta-=ible"� liscapended4 and so forth communicate very little to a basic understandieR of the deterioration of thought and emotional process which is taking place in the individual--Vbloss feelings are translated into a vocabulary of :motives which is meaningful both to the subject, ex,priezItinz the feelings and to the other tryiaa to understand the , _ \ feelirms, the barrier to communication continuos to-exist and little aid can be given, The taslAst bvfors IAA hero is to urriorstand ways in which these feelings can be more adequately and easily described and interpreted. To this end we propose to make an intensive lin:Nistic analysis of the recorded therapeutic; interview material. The approach is planned to be three-folds 1. Analysis of rttcs, that is, a ctudy of the intentions, attitudes, and of the expressive behavior inVolvcd in cocriunication. : 2. Analysis of the Rremmatical structure or syntactiCal that is, a study of the relationship of words and sentences to each other. This will include a study of the degree of looseness, precision and fragmentation, and the selectivity and flexibility of associations (according to establiehed _ laws of association.) � ".� Analysis of sc.f.anticsA_that is, a study-of content-meaning. , This type of content analyais-deals-with_the_meaning of thing4 and events and people, external -to the subject, that is, what seems most significant-to the subject abOut these things, whether thoy be prosaic, conventional-or imagitat v symbolic and _interpretive. --t-- In t1ue type of analysis, ye-expect to be guided by the extantlitetre on this subjecti-in particular, a recent-articla on "Language rehavior in Eatice by. Lerenz in the-Archives Of Kaurolay January, 1953. 5. A Study of L. as aUset'ulAdjunct, in the Hosnital-Traininfr P an ........... , ___ � --L-_--- _ Studiaa of the peat year resulted in the accumulation of sufficient inforoation to continae in inthis.arcia Considerable data has - _ _ been.gethered on the effects of the L.S.P._exporience of the personnel froA_: the point of view of its capacity to-inereaseAheir-ability to understand and aid patients. Detalled.stalysis-of-thia-Anformation has yet to -be made on . tho anount and kind of understanding and knowledge gains4 and how it ia "applied by personnel in patient cars. er--73 -16- Two grollp experiences ere planned for-further stud 1. Group scesions will be held with personnel who have had the Oxperien40to deternine the extent of the knowledge they have gained_in_the_mansgement of psychotic patients. 2. There will be group meetings in which personnel-who have had L.S.D. nd pereonnel-who he not ten the drug will participatevthe-latter serving ae, ontrols. This is expected-to prove useful in a general trining program for poroonnol patient, rianagoment, Thr, S � isTtrAzal eurou 0. E4eriztental Qubjects ' Expealable Supplies . Ag Chemicals, true, etc. _ 2.Rzeords and Photograp4 C. _Office Supp1i00 Fb Reprints Fernanent Eculiment, Travel $ 6,000. 28,000. 2,500. 200. 5tYa. 600. - TOTAL 039,500;- Tho responsible re ar hers vill corttnuo es 0 .present yy Auc. t 19i 1934 This is-to inform you. thnt=a y forme utber hus been .chana.ca lease CO not try to reach to at:the Om number. _ No collect calls vill be-accepted at this raitber. SincerelYi 00 =IVA C-0,2M)1�0 S C 3 i; IVOICZ 11:14%31.` � Dct ct Otiglava rctglocl AllcUttat Atazt Autbo ie1.1.z.t,t�Ael Cry/11mA V.,t/14,1t- O1ct1 -- Atct �.....0�01.=.0. � &IA - �--3-.2-50a�fo-V0/ -VOA 90,0a Pori c'd Ls*. 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