- SS- siZr) ,e 410 AM-- 40 �� 00 1 Cajal NIX CI ZS CjilaraTr. GIS DArt RZFERE..-m.t L.7,WILDATED 27=7-7- tf 2 4 it4A _t 4�90 � I`tsi ,Etr 4,62,1. aro 11��-, 1:A.T.ANCT �Val: a a - - -11�.0.�-��.+- f AMOUNT RECEIVED FOR GRANT EXPENSES Salary - Dr. 1;200,00 . Consultation - Dr. C___. 100.00 , Telephone and Scro erial Service 41.33' Travel-Dr. Dr. 118.30 ' Constatnt Tvmperature Water Bath_ - 232.50 Chemicals 143.46 Anderson Glass Capsule Manometer- -765,50- Magnetic Stirring Apparatus --_�_-_---- �_�_-37.50 Kodak Timer, Hot Plate. . 29.50 Screw Stand 97.727 Respiration Pump 267.111 Thermometer & Me Marker -triple _102.47, Animals and Supplies 30616 0,750.00 2,741.55 Unexpended Balance in Fund $ 8.45 , vo Pe 0-1*a 1241 tut.' :1420c/ a, 0. Qd � red RECEIPT I hereby acknowledge receipt of the following check: Treasurerl-Chee%ina. 142433 6 1. the amount of 0.03.00 c.,-reun on t - Date / 4 � RECEIPT hereby acknowledge receipt of the following check: Treasurer's Check No 20295$ dated A il 4,1.956 of .2,700.00, drawn on_th Sayable to Date 711Irr;!"7"- ' CtiiI 2eat Fro:::27 Drn310:{ ;IA: TC.42;_:72;TA 21 I:arch 191.4, 1.4....voico 1. Izsl.701e1 1 fQr :inzxoject ia attnoch(-2. Iy- YLL b=3 - chf.,21.: in tba_anwIlt 01 artnin on an cillw7:4-. i1 tha ,17;xy..lat 0? C103.0) (3ravn on a itada p..*abio to thT, 2. Tlia abova (fl }z'3 �i)1bn forv:117&41 to Cilief, 7313/Cht!-Ac.1 tvou,s4 W./3/7/1..zazet Off.-110 1atf2r-Oza 3 April 1956. 3. T1115 la a final tcittat Vt3 11:,:4-,7 thin colbproj&:.t dv.121n1Iri oinee it is amtic13:at=4 that cUlt.ionol L vill AA. thin Fojset, nhould not ba clonr.A4 Attslearar.ntst Cr.lz ff. 2 - :1dro-,E5c -.7 - C- Ti:;;LI7 GOTT LI al -1.0a C H r.1.3 z T E AM 0 LI NT OF RECEIVE .1;e 5 451. t-I E-:1,3 e ese /7e 06rvics 02803.00 .1111 +NS �I�I �� CIM2ICATION3 (1) - It is hew,by certifiod that this :Is invoica 1 applying to ,"Lrual S,,Ibrrojec.lt 55, that perfocil is cativfactory, that iar bedn:i acccplichr in assoranco with nutual 1-..biat a cii=tail:I=d of the payn7,nts and rsoeipts on filo in V;2/CD, tInt t!tilt ja:at v;:la oorrect and - that paymont threof�has-not-yet-toen CYLeft TC-34/Ch,,..iical Division Da17.-.7,t (2) It is hnreoy cortificA that this invoice applies -to MIURA Sustrojent 55, ,daich was duly appron-d, 4n1 t tho project is b21n7, o=1,--d out in acuordance with t!lc rlemorcx,dun dated 13 April 19531. fro a ths DOI to_thaIWA, and tho extension of this_anthority_- in lbsoquf:lat nnnoranda, Dat.pt _ _ �� 114.:tsoarch ctor _ r .S_ .. the cl..-41"1. P-,:).1-qtt. t2.1sLt tt). zwa 01tui.xrt-hcrit7 V-4%4 11.3 vr.PITY:roa aid cpta thr., 1.1-;_;; bnzr. ETA e:Ic.',uld be ir::::arzKil tal4i.- 11-:�Irt Fca 1,:estf;t: � � D.1:::tizitu4bar 2 7a�a-w-.7,7:,,,1 1 TO/00 TSSA7AS13 T,TVE-,3 2 IWO _ Tg' � t k 21 February 195()). � � , J(157s0.11 I C1"5".; z CIGi 7E'; ; C.. C I. 4; 47 ) t: 1;;; - Lowu,2radod-to: tY nut,!lorlty oft 187475 ?ate: Jun. 1977 E? P:IDET; CL BY 187475 r. 0:'A1DUY, FOR: THE RECORD DRAFT 21 February 1956 Project YKULTRA, Subproject 55 - SubprQjoct 55-157bifig:ill1t1dtiItd_enable Dr. to-uAart4X,,. pharneol �cal-studies of intr3 tO 15 -itn at Department of P.3 2. The scope of the project will embrace the relationship between chemical structure and biological activity of various iso- quinoline derivatives and heterocyclic compounds containing two or more ring systems. 3. The School and Dr. are completely unwitting of Agency intes in this proposed program. Therefore, in order to maintain cover, (a) the requirement for-a-Hemorandum of Agreement with the principle investigator will be waived,_____ (b) the will request Dr. accountingfroi he University upon completion of the pro- gram year. _ _ 4. The cost of this program for -a period of mated to be 2,700.00. To this-sum-must be added ing a four percent service-charge by the the total coat will not exceed 21O3.00,::f against Allotment 6-2502-10-001. one year is esti- to obtain an 008.00 represent- therefore a ould be made 9. Title to any permanent equipment purchased by funds granted the University shall be rethined by thp UniVersity in lieu of higher overhead rates.- 1.:Q..:o3ried to: 1-7 c.utboritY of: 137 > ditez-Jullo 1977 CL BI 187475 6. Documentation and accountin3 for travel expenses which are -reimbursable by the- University shall conform with the accepted practices of that institution. - APPROVED: APPROVED: /0-01S' DNEY GOTTLII3 Chief T S/Chemical Division Research Director - _2 3 4,04aicy 9-1:4 Distribution: Original Only - TSS/(D 1 February 1956) Downgraded to by authority a.: dote: J1.11)0. 1977 . Ikr9F.T; CL BY 187475 � Centlemgn: January 26, 1956 The Undersigned would like to-apply for a yearly grant beginning February 1, 1956, or 00 f.xrssearch roje o e- carried out ..in the De artment of The purpose of the study is to discover tie ohermacological effects , of certain groups of c(s.e 'I prepared by Dr. and associates of the Legartment of In other words, we. to tAke a-further step into the most basic asnects of pharmacologye-biochemorphology, or the relation of chenical structure and physical properties of new chemical compounds to biological activity. We propose to test the following com- pounds: a. Various synthetic isoquinoline derivatives._ b. Heterocyclic compounds-containing two pr more ring systems. It is highly desirable to accumulate_portinent data on all these - types of new compounds for the_treatment_of_disease as well as for the advancement of science itself. These compounds will be tested on the: a. b. C. d e. Central nervous system. Autonomic MINVIS system. Sensory nerves. Sensory nerve ends. Somatic motor neurones, This classification, of course, includes drags such as those producing hallucinations, tranquilization, sedation, anesthesia, adrenergic and cholinergic effects, and general and local analgesia. In addition, the compounds will be tested ac to their effect on the smooth muscle itself and on possible anteccenism to histamine. �,-- - 2- I propose that the following budget be provided for the project: 3 275 -Overhead for the University 1,700 - Salaries 250 - Travel and administration 525 - Animals, chemicals, and miscellaneous equipment 7-2-;7564 TOTAL Mc I add that this gront v rther step in the b tween t e Departments o Doctors results. and will be periodically informed as to the Respectfully-submit SENSITIVE IN111.1. IGENCE 51$RA 0,1111; �DZeZ. C; Mtn,af C1 ' /7?-4:ti _ I'd:V1tic:111 f1........ - - I 1 ............Y...... Y... i :011.;_.- 2.,r,-.c:ANt Az.'41,1111; tvr -...- _ ,..... ......w.... ,- _ 2 _ 1 1 1 ....1 i �If� Leo . ' - i /,,.., __,1 _ I 1 .......-...................�,G 11,11c.ttlfti; 1";:.�.:;.Ac g.� / ........................y....-...v.. ir ,.......................V.................... I �,................. .......1 - - - AC .................. .......... - ..........-=.. . 4 � - -11117111111111111111=1=1

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MKULTRA SUBPROJECT 55 (9 DOCUMENTS WITH PUBDATES FROM 560126 TO 570723)