Project 1411J12R�Veabprojecit 135 tato) Initiated' 15 footeabier 1961. Date Wrest 1 Octdber 1962 Fundeecurrent ye&rs 4214670.00 Purposim To ProYPIeTfor Ylvestigations involving c/inial testing of volunteers in proexans of-TODrintereit.r-Tbe project will provide a__ facility' and a_team of medical :supervisors as vell ass wok -stole . reservoir of volunteers, � Status: Project is approved bnt Ms not been aotivated.-Activation. will be attempted b 1 Septeaber 1961. �Cost-Account Object Class Date 9 AUG %a 1461 marks_and References Obligations Obligations Unliquidat - Incuried - Liquidated --- Balance 1Ar / ."4"1:17 402, ..14-1M14 A EmOrt A NDIJM OR: COMPTROLLER ATTENTION Finance Division SUBJECT UKULTRA, Subproject 1 5 Under lhe authority granted in the nt effloranduw dated 16 June 1961 from the Del to the DD/A, and the extension oftMa_authoritytti subsequent memoranda, Subproject 135 has been approved and 425.868. of the over-all MKULTRA_project funds has been obligated to cover the subpr ject expenses. _This obligatton of funds should be charged to Allotment 2125-1390-3902. APPROVED 1011 OBLIGATION OF_FUNDS: 'tat simd Research Virector i214\ Date: CERTIFY' THAT FUNDS ME AYAN,ABIA coQ400t3s,Rmit4cEM. vAPcAjo ALIO'rp:',...4 4,01� AliTtiOCi. 4G Of F Distribution: Ovig & 2 - Addresse 1 - TSD/OC U-ZTSD/FASS 2 - 12Jlly 1961 MORAN= CAW, 71NANCS VIA t VID/Budzist Unger SAWS WVISM, OubproJent 135, A11otafrit12125.1390 *-141191,412 NO*1 COVerind tate eolkAr ItlibPrOtot it lattatb.1* Parent should too nada as fellows: .2.�P ass fo checks to Chief, IVONsearch Drariehp WOW:A $DfD tQtticar, Ho later than 21: July 1961. t 3. Thi$ is a final invoice. Hovevero sine. it is anticipated that additincialittitads_villobligaVed for this project, the filas should Dot _tre1414e1. At chments: C44-tifications Distribution: Ori & 2 � Addresses 1 ---TSD/FASS TSD/RE: FiEL RT:r111 I CERTtFY T:HAT FUNDS ARE MAILARF4 CiALIGATON 2.EARailCf. go. gtAy_CA 10 LL17,,,,,,FNFJft _ � Atini0kZING ciFiCEA C: ":""".!:'!TOF$.Q? cel /pa/ .!NT OFrm, INVOICE-- For Services- cs � _ �4Y- en CERTIFICATIONS Miladisoinajaar:O. (1) It is he rtified that this is Invoicaj1 appipag tO subvProject N00,13s of ULTRA that performance-is satisfactoryi-that services ors1)0ing accomplished in accordance-vith MUtUal agreements, -that a detailed agenda of the payments andLreceipta is on tile in TSD/RB, thatithis-bill Is just and correct and that payment _thereof haS-not -yet been-made. _ Date: ..earme Ohlef, 'SD Research-Drandh (2) It is hereby ertified that-this-invoice-applies_to SuWOject of KULTRA v:lich_was dulyapprovedutuld-that the project isiibeing carr ed out In accordance vith the memorandus-of 13 April-1953-from-the DCI-to, the-DD/A,- _ and the extension of-this authority in subsequent memoranda. Date: Res arch-D ec cr (When ed In) CONFIDENTIAL FUNDS POSTING VOUCHER VOUCHER NO. 7.12 DATE 2.8 VOUCHER NO. 7.12 DESCRIPTION-ALL 0 HE CCOUNTS 13-33 STATION 40-42 F u 45.46 PAY CODE 47.52 OBLIG. REP. NO. EMP. No. CA 54.57 GENERAL LEDGER 58.67 ALLOT. OR COST ACCT. No. 6.8. OUE70 [ DATE 711.so AMOUNT DESCRIPTION- ADVANCE ACCOUNTS 20.33 TVA NO. F.0. foe. CODE PROP. NO.PIN,C00%. EXPEND CODE 62.67 CM.NO. X NEW. NO. COJECT CLASS CREDIT " PROJECT MO.. Y ........ 1 � � � ,�� , tr.btp.ail'e.N:13!, ...1�71/. ! i .. & Ji3ci �ei.e) 7,-2, � 0 ,..s,ki � � � . ..ra, . . � � . - ,..2.5--43,21/.-.39h-,... .e.:. I .1. . . � .647.0017 I 1 � � . � 1 1 . � � 1 ..._..... 1 ' I . I 1 I 1 1 II � � 1 � � I :1 1 .1 . 1 �, __....., :1II 1 I 1 � 1 EXPLANATION OF ENTRY i TOTALS [ I DATE 7 PREPARED 8Y DATE REVIEWED e F CE T Fl D FOP PAYMENT OR CPF.DIT ATE SIGMXTURE i H OF CERTIFyING 1 III OFFICER 1 1 CORM : e4c, A0-59: 011410 :USX PREVIOUS 'EDITIONS. 110- ) en In) ACCOUNTING BY INDIV IDUAL FOR ADVANCE NOTE: Follow Inatruct4ona on Re elad SUBMITTED BY Mub 5 ULTBA S 13 � VOUCHER NO. (Finance use on y) PERIOD OF ACCOUNTING FROM 1 December 1961 1 TO 31 Aesy 1962 RECEIPTS DISBURSEMENTS I. CASH ON HAND BEGINNING OF PERIOD $ VO CPER � N mAttoDArE DESCRIPTION AMOUNT i la. i 2.Nuazir 1 DATE DESCRIPTION Auc .,,,,t, 1 Ad ,,Ze.e Attached certifIcelti ',ego COO a 4.to I. 1sG. ...9 1 312, 000000 1 , li 1 TOTAL EX E SE C.. 4100. 11114 1 1 1 . OCOER 1 1B. CASH ON HAND TOTAL TO ACCOUNT FOR I, 000..., .1 II ,iporm.,:: Otoupregp FOR k l' I. LI 1 s ' IPA .41' I CERTIFY FUNDS ARE AVAILABLE [ 1 11 oTR,:toyED pi I 1 ICAreqyjenae 1!,col!Oen,tioll.itul CnolexpenOruires, incurreditor, 1! HIM listed le, thatH received, 1 1 freceon 'Feces) ?LlYoe7t ,and 1' And AOC. Of 1 that I OBLIGATION REFERENCE NO. 1 139 CHARGE ALLOTMENT 1).25,13 NO. DATE SIGNATURE 11 1 III OF APPROVION li , I,: 0! ,OFFIC I R, ..,o711.111,"7! POOPA,I le:rditl hilts attach,.:e0,$,Alrerre rherofo, accountinglorlieruoIendlIxiocrAct ATE i 9 �JUN 196.4 SI9iATURE OF AUTHORIZING III OFFICER CERTI 1 ri iii li i SIGNATURE ,.......,,-;- 1 1 1 1 OF PAYEE.. 1 i 1 1 11 1 DATE 1 1 1 SIGNATURE I OF CERTIFYING � FICE i 1 , SPACE BELOWFOR EXCLUSIVE USE OF FINANCE DIVISION I -.PARED BY � I I I REVIEWED , III , BY 1 1 I I 1 voucmgRiNo. I:1 II k I I II 7.12I� ' � II DESCRIPTION - ALL OTHER-ACCOUNTS 13 ail iii i 34-301 io N n PAY ............CA LIO. RIM, '' "D!"" ACCTI. EMTI. 016. SO 40. yR 54 GENERAL ACCT LEDGER J NO. !I, 11 -fi ALLOT. 58.67 OR'COST ACCT. NO., 'I 1 'I , 404/0! DUE DATE "J1CT CA.AS 5 . I _71.60 .. ...._ AMOUNT DESCRIPTION 'ADVANCEACCOU I'S 13.27 26.33 ';:i.,71;:' STATION PPOPH! " . 'P.m; EXPEN CODE:i. "' , OCIP T CM ID T '5.1!..:' I7 K '62 67 1". !?:. :!**7FI,No.. .te a; co, *I III I 1 i ii I I 11 I I 1 I I I I I I I I I 11 11 I I I I. , 1 [ i 1 I I I I I 11 I I I !I , VII 1 a !gat/ 1 I I I I I 4 I I I I I a i 1 I , TOTALS ! , FORM ,1r, 8.61 - USK PRIVIOU5 EDIT 0 g MOMfed _I =MD 012a0if t )0XLMVOrtzbprej444 Ws 914 914.fird 13, Moos taO cvietn of tho audit of Projeot-WOLTRA for the period *53, accountings ho bon received ia- the mount of 493,671050 .93 Worm to be Booctiated for graztoea at the. odd of -the audit pe Subpmloot 70 talcum& direct coati of 0,54,34 end triouxforrol. frau thdowojeot 94, for -a total of 430,390.50. ineuma_0444.101_40_ 471/324�87, but trunfirk44. 44,165�71 1}-eot 91 44d_$Z(0072-�16 toT-%11-ProJeot 70, 1etkv145 met *OSt of SSA VS. dooLded_to_divert_the fonds for Subprojeat .133 to Wyprojest 91, therefOre those cote vete 1=111444 in the weak-114ratruSubprojeet 91. Nasmoh as: _ 1) ail row of the subtir-NoToU had the sem batio to - switch goal in said, 2) the groat leagth of tito that, bas clod since the groats wre made atid 3) the difficulty ingettlas a000untiess of at Reit frog the, p it IA riteeagtM1434 that ueGfaallitate_this sat. ter kr ascot the balatoesae e4W.in in the 0oIlfidootial /Ws DifittiOA 760 acouit- for those subWok,We Tho above has 'bawl ocaourted Statt* Oranfs February 1? 1961 to January 31, 1962 000.00 Less, previously reported February 1,1962 to July 31? 1962 Total � Accounted fori-as�follows: Salaxies Payroll Taxes Baployee Benefits Laboratory Supplies and Expense Travel Other Direct Costs Indirect Cest* Total Costs iiii7FRif64ily reported Total Accounted For 441P6MQ 1- --------__ 644 O'er ikdwass.00.001� ,S4,1- qi ,131.14 . 1,460.08 355;68 3511,8 569.63. 2,569.17 2 � 26 At - Date of Origloal kd Allre,7,7-it6at ttraturt, of Aathorization Covetzia To- . : nitib-;tt ifezi Alditional AlIthorizat TI,Krza 13x.tem.1./A. Coirztred To Paxamt. of Oblicabloa � ,,,..( ..... s=+��*T.,....... 1 0......w.c.....v. �40.=�.1 _.....m, as .ft, ,am.y. _ _.=.L_L. � .....-., 1 1 - i / .. _ _ .....�, �.� - -. ---, _ _....� _ ____.1-- - , a,. 4.. Larlakla ttacuat 1 Iii70`9110 C!fl LP mariERA Subproject At - Date of Creifdtz%1 ilsd All rt hiallit of - Authorization Coveral 1,01),a,r Ctzligation ��.. Al_ditickt 121.r..3-AX t-g)114I-4 1 e Gat cavAm,41/4, Atitrizat1oll ---": virsoicabo � r _ � 121allInt'�,1 - 4 16 st 1961 We are pleased Ob. able to transmit to you the follovein fUndes: These funds represent a contribution for the uae of your directors ili-cir-rying out the very worthwhile research goals of your obligations, Yours Attachments (2) DRAFT 31 May_1962 MEMORANDUM FORTHE RECORD SUBJECT : Project MKULTIWSUbproject Change of F�aciIity in which_ Work is_Perfortned- 1. The original purpose of this subproject was to evaluate a number of candicate_chernical agents in facilities and under the direction of individuals_who, if later developed, became unavailable for this purpose due_t_o_mfor_en circumstances. 2. In the meantime, the funds for thisznibproject_were transferred to the_cutout_in anticipation of the commencement of the work. 3. In view_of the security difficulties involved-in the actua return of funds frotri_the_cut and also since another subproject (#91) was being served by_the same cutout, and furtherrnoresince Japroject #91 was capable of providing its services on; these chemical agents of intereetArtdduring the same fiscal year, it- has been decided to divert the work intended for subproject #135 to the facilities of subproject #91. No sliiicant change in funding or variation in fiscal year is concerned in this rnatter. CONCUR: - Chief, ca S rvices 'vision Date: TSD/Research Branch Distribution: Original only fj 112MOBAXLM VIA SMUT 10101LTI1ubproject 1351 IrtiMita. 1 Allotment 21254390=3902: C/MAY, ITRANCUDIVISICSI ,iSDIBt Officer 1, Invoice No._14overidi the *boy*e ctttscbe4. Permit Should made evfollowst 2.- PleaSe_forvard the cheeks_to_ChieL4 TSD/Reeearch Brian throush TSD/Dud thew get Officer, so later July-1961. 3. Tide lice titFlnvotce. Dossier, sine* it is **tic/rated that additiodal 11fl4s obl t�4 for this project, the files should sot be_oloutd. Attack= I -- TAVOice & Oertificetiods Distributions ()rig & 2 � Jttresses 1 - TSD/77428 TSD/RB - For Services ..s M . CERTIFICATIONS (1) It is hereby certified-that_this applytuAo_axtproject No. 1.15_pf MKUITRAI-that performance la satisfactory, that services are beind accomplished in accordance-vith mutual agreements, thatTa_detalled agendalof the payments and receipts is on file in TWEE, that this bill_is_just and correct and that payment thereof has not yet been ma4e, Date: ChIef,TSD/Re8ea--ch$ranch (2) It is hereby certified that this invoice applies tolSubProject-5 of MUM vhich-vse-duly:approvedi- and that the project isLbeing_carried out in accordance with the 13 April 1953 from the_DCI to the DD/A, end the extenaionofLthisauthority in subsequent memoranda. Date: Research DfircM77777 MEM 11ANDUM ; CO/APT14-01.1.Ett� ATTENTION ; --Finance Division SUBJECT MKULTRA, Subproject 13 16Jne 1 Under the uthority granted la the memorandum dated 16 ,z 1961 frora the Del to_thi DWI%) and the extension of this authority in subsequent memoranda. Subproject 135 has been approved and M, 865.00 of the over-alt MKULTRA1)roject funds has been Oligated to cover the bprojeet elposes. This oblWtion of funds should be charged to Allotment '212$-1390-34 APPROVED FOR OBLIGATION OF FU Date: Distribution: Orig & 2 .-Address TSD/OC 1 - �TSD/FASS 42--::-TSD/RB MEMORANDU SUBJECT DRAFT 16 June 1961 FOR: 1111 --THE RECORD _ MKULTRA, Subproject 135, 1. The purpose_of_this subproject is to provide funds to carry out a research program involving utilization of human volunteer subjects. 2. This program is designed to exploit clinical and laboratory facilities and professional klumledge in providing answers to specific questions of direct inte-rest to the Agency. The nature of the investi- _ gallons to be carried out efxo passes pharmacological and clinIcalIIIiIIIIiII testing in human_volunteers of chemicals, biochemicals, and biologically � active materials -under controlled conditions. For example, human patch testing or human bl&sd group determinations will be mounted upon setting up a suitably designed experiment. 3. The investigations will be carried out under the general super- vision o This individual will serve as project c: leader and coordinate all phases of the research program, select and provide clinicians to conduct the experiments, assist in planning the experimental design and protocol, and supervise the preparation of data and reports. The attached proposal indicates the nature and extent of some of the investigations that will be carried out. 4. The funds for reject will be transferred using t 'Oilt-out. . The cost of this pfogram for a period of one year_beginning 1 July 1961 will not exceed_$24,870.00. To this sum must be added_$998.00 representing a 4% service charge tot ho will act as a cut-out,:making the; total. amount $25,868.00. Charges should be made �inst allotment #2125-1390-39_02, 6. Th III require the princi- pal investigator-who adminiSters'the, grant to submit to them_a summary accounting u-pon anannuaLb�isioLa1Lm�nies received from the Also they will require-that any unexpended funds be returned_as_soon as possible upon the close of_the grant year. 7. -The requirement for a six months informal accounting on the part of the principal investigator is waived. 8. It is not anticipated that any permanent equipment will b-e required for thii program. 9. It has been -agreed that documentation and accounting for travel expenses which are reimbursable shall conform to accepted practices. 10. It is agreed that technical reports reflecting the progress of the research program will be accepted at mutually accepted intervals. 11 as signed a memorandum of agreement and holds a TOP SECRET Agendy Security Agreement; The project will be unclass- ified after it reaches th TSD/Reearch Branch APPROVED FOB 013LIGATION OF FUNDS: Date: Attachment: Proposal & Budget Distribution: Original only PROPOSAL _OBJECTIVE : � To establith a professional organization for the primary purpose of servicing and conducting complete clinical evaluations and testings upon demand. 'If addition to prescribed activities, to maintain itself on a standby basis and to be able to mount clinical projects on-an-ad hoc basis. PROCEDURE : see attached sample protocol for patch testing. CLINICAL FACILITIES: LABORATORY FACILITIES 3s--- (t) Th PROFESSIONAL STAFF / BUDGET: ( 12 months period ) Principal investigator 10,000.00 Professional staff 6,200.00 1,800.00 Secretarial Eapendables, chemicals, supplies 1,600.00 CliidcaLstibjects, fees 2,500.00 Travel, maintenance 2,300.00 470..00_ ,Insurance, malpractice & liability Total 24,870.00 no overhead or fee OBJECTIVE: PROTOCOL To determine whether an unknown compound, either chemical or biological, is capable of eliciting a reaction-when applied topically to the skin, either locally or systemically, or both. BACKGROUND : - If the skin is able to deal with the irritant compound, the reaction is physiological or normal. However, if the action of the irritant is ex- cessive, th-e-reaction is pathological or abnormal and irritation results. Irritation is an extreme reaction of tissues to an insult or injury and is best characterized as incipient inflammation. = The iTiflammatory process _ may vary from a barely perceptible hyperemia, to edema formation and vesiculation and finally to a-suppurative process. A primary irritant may be defined as a substance producing an injury on first contact, The resultant injury will depend on the nature of the irritant, concentration of the irritant, and the total elapsed time of exposure. Primary irritation of the skin is usually measured exper- imentallyby_the patch test technique on abraded or intact In of the ex- perimental animal, for example, rabbits, guinea pigs or man. Exposure of man is predicated on small animal studies used to screen all compounds to be tested to obviate exposing man to severely sensitizing substances. Granted, in the case of compounds whIth may be only mildly sensitizing or in which small animal studies are_unable to furnish unequivocal results, man may appear to be the only feasible firial test subject. Animal experimentation data should include acute, subacute and chronic_clerrnal toxicity experimentation that will allow some logical assessment of the local and systemic toxicity of substances_to be applted topically to man in the proper amounts, concentration and frequency of application that may be tolerated. PROCEDURE : For pilot_studies, human testing should employ 20 test subjects per compound tested. Prior to experimental testing, maximum efforts must be made to minimize the risk of incurring unforseeable sensitivi- ties and untoward responses by establishing a baseline profile that will encompass the following : 1._Complete medical histories with emphasis on known sensi- tivities and drug idiosyncracies. 2. Preliminary physicial examination 3�Hematologica1 evaluation ( complete blood count) 4. UritTalysis ( microscopic) SRadiological screening ( chest and long bone) Acute dermal toxicity. ( Single exposure-or primary irritation) This will utilize the patch test technique on intact skin on a min- imunrof_fiwsithjects per test compound.- Methodology will consist of introducing under a one inch patch - 0.5 ml (liquid) or 0.5 gm (solid or semi-solid) of test substance and securing the glitch in place with non-sensitizing adhesive. After 24 hours, the patch is removed and readings made on the resultant reactions evaluated on the basis of the following scores: ElTaluation of Skin Reactions 1. Erythema and Esthat Formation No erythema 0 Very_slight erythema (barely perceptible) Well defined erythema 2 Moderate_to severe erythema 3 Severe erythema (beet redness) to 4 Slight eschar formation (injuries in depth) 4 11b--tal-Ossible erythema score 2._ Edena Formation No�edema 0 Very slight edema (barely perceptible) 1 Slight edema (edges of wall well defined, raised) 2 Moderate_edema (raised approx I mm) 3 Severe edema (raised more than 1 mm-and extending beyond area of exposure) 4 Total possible edema score Readings are again made after 72 hours of exposure The- final score represents the average of 24-72 hour readings

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MKULTRA SUBPROJECT 135 (16 DOCUMENTS WITH PUBDATES FROM 610616 TO 64061 9)