/-460/ -84iINHET When Filled In BY INDIVIDUAL SUBMITTED 61Y PACOLTBIAALACe2mlectida_ DATE . VOUCHER NO 2.1 ACCOUNTING FOR ADVANCE. . PERIOD OF ACCOUNTING NOM Follow Instructions on R FROM 3.963 TO 31 Ausuat-1565----- 1. CASH ON HAND BEGINNING Of PERIOD S. EXPENSES THIS PERIOD: 2. OUTSTANDING ADVANCES BEGINNING OF PERIOD VOUCHER NUMBER DATE DESCRIPTION AMOUNT 3, E ,..CEOPTS THISPERIOD: t 0101, IL tli0i RECEIPT 'UMBER DATE I DESCRIPTION Met 1161:60 '1,------J7/2-20ileste #77ca83 � 0=29 , , [ TOTAL EXPENSES [ . REFUNDEDi UEPEWITN 0A60:: CN1CX NO cr.:mace ! II 7. ppysiTAND MG ADVANCES END OF PERIOD 1(Attloch listing) ! 1 e. CA50.11.$* HAND IEND,Hr'IRER1014 015 BALANCE pic ADVANCEE � TOTAL TO ACCOUNT FOR SA *S. � 9. I [11 [ 1 [[ IIITOTALI ACCOUNTED FOR [ I II 11 I .21.� .1;9;L.. I CERTIFY FUNDS ARE AVAILABLE [ II I APPROVED � III1.0 11,, 1.! [[IIII[[I II IdIcertylthotitho! expendtturem! 'listed hereon and OIL G.REF. NO. CHARGE FAN I ACCOUNT NO.. 1:* : � DATE !I ! . I 1 SIGNATURE MUM OF �! 0727=k APPROVING i 1 OFFICER1! De! on : any poses!!!!,of erectlt,,therefee,'Aele tN,N1, !.tf,,,,,t1!!' a0WOW9#entle, accounting is were!!!Iltrred. .true not inetfrFft,,thwt!PwWwwwt been ehdl,correct 1'09 ,received, official pur- or , and thet 1 DATE SIGNATURE OFAUTHOR ZING OFFICER cEpT F 'ED FOR PAYMENT OR CREDIT SIGNATURE ! , OF PAYEE' I 1 L , ' DATE !I SIGNATURE OF CERTIFY!" OFF1 FAL I I SPACE BELOW FOR[ EXCLUSIVE USE OF OFFICE OF [FANA CE 1 SCRIPTION.ALL OTHER ACCOUNTS 13.33 94.99 STATION !COOE!!!! ..cc offi. ','WO x.000.0lc, 'I I 00 ' ,. 40.1 41 C ',, 0: ,C 0 ! N El p . 1 I 42.471 'CIOLIO � �',"�" ADVANte ACCYI. 'NO. .77.1.7.I" (0[11P,1 'N:C. 46. 411 PAY PER 0' LI . Me 50 CA OR 51.54 GENERAL '1 55.65 . I COST . FAN 1 ACCOUNT SYMBOL 1 47.70 OBJECT CLASS : : 41..00 AMOUNT: !! ' I ADVANCE ACCOUNTS: 1 I 9027 26.33 T/4 NO. � .,,m3 . 1,.'�� C (i' T V0.1 LEOGFP ACC*, NO. � . : II . 0 � :i. 051�56 cx. xp. X REF. NO. 66.70 DUE DATE DEBIT CREDIT � � . . ... � � ........ - . . _ . . : . . . : . DATE 1 PREPARED BY DATE 11 REV EyED BY I I TOTALS [I FORM 4.65 09X3L'EXE PREVIOUS EDITIONS SECRET 10710UPI �2=7=41220111=1:' � SCHEDULE FOR -- C-FUND DISBURSEMENT No, 109 1 July 1960 1 October 1960 - TI 1 Ja nu a r y I961 1 April 1961 . Z70:00 _ 5,Z70.00 5 Z70 00 , _ _ 5, 270.00- Project: Subprctject 109 Date Initiated: July 1960 Date Expires: November 1961 Aulds�curient year: $2.1. 923. 20 Purpose: To deltelop bioaesay andltartnacodynataia technique* in the field of ensyrnologfrequired Wthe RB chemiaLagtat program,- Status: Prelimiaary survey work IS latht yet completed since the program is ouly ia ts eighth rocath, JC..1.40,C (When Filled In) ' .1.� aam. li'S.t - a'; ACCOUNT ING BY INDIV !DUAL SUBMITTED BY 11203LTRA, Sub-prodect 109 DARE VOUCHER NO. 2.12 FOR ADVANCE ! .-PERIOD OF ACCOUNTING II:. NOM: Follow Instructions on Reverse FROM 1-----2-11963----'7,---31-AUggid-1565----- . TO A ALUC.) kiAltil 19 66 I. CASH ON HAND BEGINNING OF PERIOD $ 2:11�0804X) 5. EXPENSES THIS PERIOD: 2. OUTSTANDING ADVANCES BEGINNING OF PERIOD ZOO: DATE DESCRIPTION AMOUNT 3. RECEIPTS THIS PERIM/I enae �� See ettedie/1 RECEIPT NUMBER DATE DESCRIPTION lacialeet 21 -.012-241=09-oktt-250A0-,------ ,..__AZIALTA032,09 ,....: I TOTAL EXPENSES- .: � . agroopcolhe!cwiTit ] 1 .1cAsw I 1 1.,tomca Imoagygapag III 7. OUTSTANDINGII AOVi.NCESIE 0 OF I PERIOD I (Attach1 hating) I:II I S. CASHkION'HANDI E vioFILIPEal D IICNV BALANCE DUE AOVAHCEE . TOTAL TO ACCOUNT FO A"I 60 9. Li II I' I 1 I IIITC,ITAL 1/1.1:COUNTp: FORI 1 , 1 Il .: 1 41ZLo80.oO I CERTIFY FUNOS A E 'AVAILABLE ! ! APPROVED : HH ,Il , I ',1,W : , Alie44 li, certify 4 T Joo expenditures 1 1 II ' tiatedIhere n and 0 1.04.REF. NO. L....._.0.1.......__LL:31.390_3- 1 CHARGE FAN 1 ACCOUNT , NO. DATE SIG gOOMIX /JURE , OFAPPROVING1 � I I':' .4 I ,111 9 1"; 1poaea,I, ''true OFFIC , I onany credit . accounting attachments Of ; there : a IHI.confidentialII for , were hVeI.! IN6EitsnI,I'receved, IS! tr� . incurred nature, ea 1 correct. for official ;I that payment ono our. or that DATE : SI GNATURE OF AUTHORIZING OFFICER1 CERTIFIED FOR PAYMENT OR CREOIT SIGNATU RE 9.4H '4TEC 0 . DATE 1 I �04! SIGNATURE OF CERTIFYING, I OFFICE I 1 SPACE BELOW 1 FOR EXCLUSIVE USE OF OFFICE OF1FINANCE OESCRIPTION.ALL OTHER ACI.OUNTS 13-33 34.39 I, 0- 41 IE ..t,, C e g E ' 0 42-47 I OBLOG. REF. NO. .. '424".."::. -4� **** cm.. No. 46- 49 PAY PER. Llo. cope 50 CA OR C : w 51.64 , "I GENERAL I I , ACCOUN1 55.661 COST � FN SYMBOL I I A , I 1 . OBJECT CLASS 67.70 71.64 AMOUNT 1. DESCRIPTION *1 - .DVANCE ACCOUNTS 1.3.27 ' . '1 , 26.33 01. .0. spoP,00c.No. ""...........".4 1R-111 STATION CODE 4 I r'.cw7 71,10?Le71 LEDGER ACCT, NO. 1 ., ..u. r:N: Yobs , 61.6 I CAH MO. !I '... **** 1 * .. x RER.No. 66-70 DUE DATE DEBIT CREDIT . : .3:. : q41: tot 0: � � 1/99. 0 f. /P faill, - � , : :`0: � �64 ?fit. , /0 i i :ZS Vafr.$ 7 746 . � ..., � 1. � ** . *** - 1* * ' � � :: : : * " � � � ' ***** * � � I. . ** ' *** 1::: � l� � � . . . ..... 1. � ' � . I. '. '....4 . 1 , �� : . � � ,. DATE , . DATE REV EWED BY I . . 111 1 . I TOTALS / 4ra _ FORM In. ME US 4.65 4.1� 0 1 00 0 -431EC4W4 OROVP1 , 41.491 EXCLOOSO PROM AUTOPEATIO 001,01.1 . OS/USN() ASO orcLmourovArlos This 1e is to certify that I have received an acoounting for MUM_ Sub.prejest 109# tnvoiee 3# *blob refleets expenses ia t &mounter $210080413(4 This_aceounting is being retained in the-project file and is avrailtible_fOr_review_by the specialW deteitAated_cert officer. I INIrther_oirtify that te the best of rw Moil/14480 and holies the expenens-lieted-14-the aeocuatiNg were for the purposes-authOrised in the approved-activity(' GA irif 1 Untitled from eeteresli devigrelles led kneteltitatian Dear Dr. In accordance:with the your grant to Dr. enclosed in duplicate Is the final expenditure report.- - This covers the peri,od September 1; 1963,, to August 31, 1965. Vet- r /07� Project Titlow Th Principal Investigator .D. Pro slow a ad of the Department,. Pharmaceutical and Vedieinal Chemistry. College of Pharmacy Unantumbered Wane* Dm t.; August 31T1965 � !teak agotareol. rEALEIALiak Outstanding bymenta Encumbrvis.�1- PersoanaIs $ 2,114.25 $ 2,114.25 $ s OP $ .0. Associated, AssiStanta: Consultants Supplits and Materials 3,052.44 3,052.44 .0- . .o. .0. EquipmeAt 11,544.79 11,544.79 Travel 1,470.96 1,470.96 Sub.Total 18,1827,44 4 isii81;44-4 o. 7% Personnel Budget; To Corer Ret..SocaSce.._ 141-00 148.00 In.. in of Total Budget; To Cover Indirect_COtts 2,749.56 4749.756 . .0. Total ,$ 21_0080.00 irdaTO = 243620-4609a- The to; t/cs ice C/7 i- 7 - 3 C If 376 -o? 7-6-3 T1DIiriL -Du (56E Memo rm- pip 2&- 63 /o7 /0, Dear "Witk.refeience-Lto7Your letter Of QCt_O'ber_ find enclOaed_acctiy of our report of A, _ and copiles-ofik-Ortespondence from Dont6 If the bast's' fer_this_reiort is not correct or if you de- sire additional. information, please let me know. - Enclosure NTEROFFICE_COMMNITION - Diitc../FJLU3iAXr-2�64_121t1�L in accordance with_Docto r instructions (per � telephone: Thurtday_afterni� 31 Jan ar 63 I oho like r � t_that you autait to -th idditionai wawa. Biteuto gLtAltla-kep n connection with the grant award anncanc _10 jteport, LISAA1. &mit um, in th the grant award announced_ln_Doctor__ ter of 10 Decetsber1962._ It is my underatar4ing that no other fiscal reports _need__ to be submitted. 9 To: of the Monday afternoon, 26.August 19.3, t e conten s of my memo1pf 26 February 1963 should be revised as follows: Please submit to the 1. . 2WagailkumallEtkral Report,� datedil Se tember. in_conn ion with the grant award.announce ------- -,�,� - tor. -1.etttr.s.YE-6_11_01LembeXJ-9_61.--...� ..----- II. Only one Terminal .1121.6 dated 1-AugusU1965 in conneaTa7VorrEhe grant WWF4 announced .n letter:of1101December 1962. idAVC.E # 3 It is my understandingthat no other fiscal reports_need t be submitted. AL:sh cc Doan Dr. tho_tortas of your gritat via . onclosod tn duplte4to to ttbe final report for tbe grant period Devoe.1:41_1, 1961, to August 31, 1963. /07-9 Project Title: Principal Investigator: by -t at t Budget Report o RsearebPe�j� beeeAber 1, 1961 to August 31, 196 Ph.D., Professor and Head ef the_Department of rmaceutieil and Medicinal Chemistry, College of Pharmacy, Deter August 31, 1963 Item Appropriation Outstanding Unemeumbered Panisima_Kwantasti Balances Personnel; Associates, Assistanti-&-Conaultants $ 4,420.36- $ 4,420,36: $ $ Supplies and Materials 5,053.14 5,053.14 Equipment 1,316.63 7,316.63 .0. Travel 1,230.88 1,230.88_ Subtotal: 4 18;021.01 $ _18,021.01 $- .0. $ .0. 7% of PersonnelBudget; tp cover 309.43 309.43 .0- .0. Rat.. SO4. Se / 15% of Entire Budget; to cover 2749.56 2,749.56 Indirect Costs Total $ 21,080.00 2 �080.00 -0. 10�640.aelidagair.1.41.1�41=-,- I certify that t7ervint17 nr -!,!:,r!fils have bee!". satisfactorily - -0 oxDenditures -- vere incurrctd en cffialAt NO- by the at-th Budget Rsnort on Research Project rimorted December 1y-1961-t May -31 -196.2*. Project Title: The Synthesis and Diochelnolcal_vslUation of_Potehtial Psychopharr �logical= Agents. Principal Investigator: Pharmacen Pate: ItTay 31, 1962 Item Professor and-I'!edical_Chemistry, and Heal of the Department-t- College of Outstanding Unencumbered Encumbrances -_ - --Paymnts Balance -- � - Personnel: $ 71000 02-- Associates, Assistart & Consultants $:-499.98_ _-0- Supplies and Materials 3,890.44-- �1,749.30 33.50--:- 2,107.64 _Equipment 4,745.00 2-1146-�14__ 2,4,29.81 169.05-- Travel 1,670.00 - -0- 636.07 Subtotal: $17,805.44 $2,I63,3l 93912-.78 00 - 450.00 7% of Personnel Budget; to cove 525, 35.o0 .0.1_ Ret.-Soc.See.-1n. 1,929.91 15% of Entire Budget; to cover 2,749.56 � 819.65 Indirect Costs Total $21 080 00 $6,2&.00 $2,463.31 $120337.69 io Budget Report on-Research-Pteject Su orted ember 1,1961 to August 31,1963: Project Title: The Synthesis and Biochemical EValuation of Potential_Psychopharmacological _ Agents. Principal Investigator: Ph.D., Proftsor-and-Head-of-the_Department of - Pharmaceutics and Medicinal Chemistry, College of Pharmacy. Date: August 31, 1963 Item Outstanding --Unemcumbered Encumbrances Balances ApproiaaLlaa --Payments Personnel: Associates, Assistants & Consultants $ 4,420.36 $ 4,420.36 $ 0- Supplies and Materials 5,053.14 5,053.14 Equipment -0- -0- 7,316.63 7,316.63 Travel 1,230.88 1,230.8_8 -0- Subtotal: $118,02401- $-18,021.01 $ -0- $ -0- 7% of Personnel Budget; toicover-- -------- 309.43 309.43 Ret.- Soc. Sec. - - 2,749.56 2,749.56 15% of Entire Budget; to coveri -0- Indirect Costs Total t 24080.00 21,080,00 0 rt: I- Co-1/230.41 '7-1- ii-zo- 01 I '04PIDAZovet) bvileqc.et, 4:1) 680, err) ALI; oFt so, try c1S-6.-ro AP PIZaeRL4ruml PA YNICAITS - tn. a 54 4,. cry .2-11 el, 2.5.2. 1-1 i Igil. it 1 II 'IN1 080. EAJCt.)Alt3 ,c163.3/ ugavc 84 4 - 17, 2,i7. MIS _ Datt_lt_rehniary_i_le DERATIODAL-ACTITITIZE_SWORT Bra rich__ BB , Catego Deh aviorantrol NaterialaL _Alfa Synthesis and evaluation of potential_psychophar- Proj-t Title ma_4_ecfric_2__.0 kal COODOUnd. Item Classification Project Crypto__,. NEM Cryptcl Classification____Unclassified_ Contract NoMTRA_11109 Type of Contract Task No ��Ntrite Date Initiated�Jigy�L980 CosL 1T43 11.92.1.2.0___ Completion Date_30_-_,Iune_1964 Purpose: Elucidation of interrelatiooships between molecular con- stitution and biological response of chemical-Compounds of interest to TSD. Status: Ternidia-puar-of a basic biochemicsi. research. All-bOt- the Sinai phases of the research has beeh-completed-and-the-- -- reports subMitted. Reports relating to final-phases-of the contract will-be received upon completion; Requirement: kite-many generated in "MD by peed for_sPeeial-biolo- ically_actiVO compounds and basic information of their characterization. Date #60 REVISED September 1963 BEHAVIORAL-ACTIVITIES SUPPORT BranchBB Category Behavioral- Control Materials Synthesis-and,evaltation (formerly Vb) of potential-psychophar- Project Title macological compounds Item Classificatio Unc1asified Project Crypto Branch Project No MKULTRA A. Contractor_ Crypto Classification-Unclassified � Project Engineer Contract No IIKULTRA # 109 Task No Type of Contract__ 1", 1 July 1960 - Date Initiated Cost Purpose: Status: $211923.20 Completion Date_ 301N_o_vember 1963 Elucidation of-interrelationships between_molecular con- stitution and biological response-of chemical dotpounds of � intPrest to TSD. 1 1 Terminal -year of a basic biochemical -.research. Requirement: Internally generated in TSD by need for special biolog- ically active compounds and basic information of their characterization. I have receivt-d the check f thousand dollars) froth th- Please accept my sincerest thanks. By Air Mail ThiS�is just a brief note to let you know-that 00 three by .the Beorton.Researeh Project caMber 1, 1961t4 May 31, 1962 Project Title, The Synthesis and BiocheMical Evaluation of Potentia1_Payehopharmacological7 Agents. Principal Investigators Date, May 31, 1962' Ph.D., Professor and Read of_theJDepartment of. and Medical Chemistry, College of Phermacy.-i Item - �attending Unencumbered -- prriatiort- Payments Encumbrances Balance Personnel, Associates, Assistant4LConsultante $-7,500.00 $-499.98 - $ 7,000.02 Supplies and Materials : 3;890.44 _ _ 1,749.30_ 2,107;64 Equipment 14,7145.00 2;146.14_ . 2,l29.61 169.05 Travel 1;670.00 636.07 1,933.93_ -0-- Subtotals 07,805.44 $5,42905 ____$.463.31 $ 9,912.78-- 7% of Personnel Budgetvto_tover 490,00 525.00 35.00 .0.- RetokSoceSCti-Ins� ! 15% of Fntir4 Budget; t:coverii 2;7189.56 81945 1192901-- Indirect COsts Iftiol�=6,1110.11..1.1ANII omp.intaga0.01111.31P� Total f21,080.90 $6,284.90 $2,463.31 $12,332.69_ _ itt RECEIPT Receipt in hereby acinowled*Ufor the follaring, two checks: Treanurnrs- check- No. in the Treasurer's - Check NcL In dated 27 ble caiber 1962 SECRET (When rifled in) NAME OF ADVANCE DATE 10 1962 AMOU24843.20 (IIIiwOJCHER 424080.00 NO. (finance us� onljt) REQUEST FOR ADVANCE December 329926-13Ft27 62 OF FUNDS PAYABLE TO See At-taebed Pant Inat. ROOM 1! BUILDING TELEPHONE EXT. .__:12.1._____i�Vaatoot�_28k3._____ PURPOSE iikdIrapeee to PICOLTSA for oda advance Tbe check aboald 26 December 109 Inv. 3 for activity approved. by ACJITCD on k December viii be in accordance vitb Attachment A of 142COLTRA Fiscal be foritrarded to ISD/1110, tbroueb TSD/Bodget oNficeri, no later 2962. 1962. Account1.ng Annex. then STATUS OF OUTSTANDING 1 ADVANCES I okras thor f will fully � account le* Or reporting poin:i�ta tad and orir000xpOrofocIlbal000'O,Ifliaoihorilsoldoofoctioollfrou for 04 � Advance bynubmiamion by the due datechebked Or eforoualtere better: In otttOrr to effect the and selund of event alloy failure ofe 0 anent. ,otny unexpended to Co ace:moot balance and refund DATE AMOUNT, 1 U TED A ,(,i 1 11:: REPORTING 'POINT 1 : I 1 : ' h' '1 1 11, DOE DATE FINANCE DIVISION;-; HDAOOVARTERS A 1 11 1 11 , 1 ON ARRIVAL ON, OR ABOUT AT DESTINATION 1 1 [woRK0Av MONTHLY .1 OF ON THE LAST EACH mown, 11 1,111 I I 1 REOUEST NG" OFFICER' I I 1 ' APPROVED RECEIPT11 FOR IFUNDS ADVANCED1 1: DATE 10 Dec. �10 SIGNATU E 1 RATi 1 GNATURE OF, APPROVING OFF 1 1 ICER , , 1.144F-Anowled88 under I to be Used , ,�,,, shown above. receipt for, the] of funde::in putpeee, at the amount land stated accounted bery- for I II CERTIFY FUNDS ARE AVAILABLE S810.0.4 1-,6 MII, 'd i/KI4:44 DATE ' , 1 ' AMOUNTJ OBLIGATION REFERENCE NO. CHARGE ALLOTMENT NO. , CERTIFIED FOR PAYMENT OR CREDIT l' 1 3125.4.V0�NO2 DATE AUTHORIZED CERTIFYING OFFICER ' 1 SIGNATURE OF ADVANCEE ,I DATE , 1 I 1 SIGNATURE , :SPACE BELOW FOR EXCLUSIVE USE OF FINANCE �IV'S ON PREPARED BY 1 , REVIEWED 1 ; BY 1 VOUCHER NO. 7.12 , CSCR IPT ION-ALL, CETHER,ZCOUNTS 13.. 3 /34-SO ' STATION CODE ****'1060E.' PPOP.010. - � I I- � .., -- � EXPEND ' I I 1 -1 43 � F. u N I) 4565 , .. o.� *^* !..110, 020:1E ., REF. oCCT.144))0* *****. 164. 47.$2 , NO. 7n" � NO. 1 PA NR 1 : GENERAL LEDGER ACCT. II , NO. , SS-67 OR ACCT., NO. 6S� 70 DATE ow.wwLT1 Cl. ASS 71-SO AMOUNT - DESCRIPTION- ADVANCE ACCOUNTS ; 13.27 III 20.8 TilA p.o. NO. No. 4 132.33 1K., DEO CKKOOT 1, 1 K, x � oo, 0. o **Jew? NO, , , 1 : , ;IVY S IIIIIIIIIIIII, I I 1,1 I, lJ..,1 'I ill 11111 11111 I ' 1 1 111 ,i, 1 1 1 I III: wo 10 I T''' fp/ yroli Si I 1I , I I I I I Ir's r I- 1 IT lII' 'III ) i I II I I )I 1 I 11I SI II .1.1 ' ))))1 I ' ) ) 1 ; .- I, ' 111.. '6 ; f ( ' 1' .\ , . i 2.. I � ))*')1.-'-) ' 11 I it.. II v ivy , .1,4 li 1 i 1 , , if 1 1%-f t i 1 1 1 i 1 1 1 v 11 e'ON -,, ,,,,,,,, ( [ I 1 I ,,,,,,,,,07 ,r ,4 / 44 ,ell 1 . g 1 1 lit) d I 0 , :II'I'I. I 1,i1,--IIII I 01 I 'I'll I I I I I I 1 11 ,1 I 1 I 1 I - ' : 1; '1 � �..... 1 TOTALS 1 I I i s , j4 (.. , ,,i� I I , e 31254390-.39Ce CosCAccount:J _ Object Class Date. Rein ks a.ad R_eferences Obligations ' Incurred LitidjtL Balance Obligations Unliquidated 15 iovember 109 Autbor12ittion U3 sa, 080 .00 3125'43W.3902 4�i 4 DEC SECRET (When Filled In) REQUEST FOR ADVANCE OF FUNDS NAME OF ADVANCEE 11111111Mb DATE 1011eceldber 1962 AMOUNCAV.3.20 (Itkeitp)CHER NO. (Finance use only) $211060.00 ROOM 121 OU1LDING iiestout TELEPHONE EXT. 2841 PAYAOLE TO 13** Attatite4 ParBont rriet-+ PURPOSE AdVanne to patuMA 109 Inv. 3 for activity approved for this advance *113. be Izi accartiatica id:Lb Attachment tee deck ebould be forwarded to TISD/INAD, through 26 December 1962. _. ., by AC/1330 on le December 1962. Accounting A of PIXLMIl Fiscal Amex. 1240/De4get Officer, no later than STATUS OF OUTSTANDING II ADVANCES I i agree to toot any lain reporting xplended Mot I ell] fully deqWg �tat' balance. I Mothera account Widi.rdjbY for this advance by submission of vouchers and refund of any 0e gijue det. checke4 billow. in the 'event to I' frriWure to ONO ' se detluoition from my celery to effect settlement. II, IIII enespooded percent I and I be! once refund , DATE AMOUNT I UTIACEOVNTE000LAP4CE III 1 I II I [ I I REPORTING POINTII 1 I I I I 1 I I I DUE DATE' I I I I I I FINANCE II II I DIVISION I II IHEADQUARTERS IIII II 1 II II I I 1 I I I , I I I I 11 I I I I I III I II IDNIARRIVAL ON OR A6007 AT DESTINATION, I I 1 I I I I II Il 1 1 I I I II I II I IMONTHLY .1jION THE IIWORXUAV OF EACH LAST MONTH 1 I I I I I .I I I I II I I I II II I 1 II I I I I I I i REQUESTING OFFICER I I I APPROVED I di I I I I RECEIPT FOR FUNDS ADVANCED DATE S 1162 1 I I DATi I I I I 1 I 1 SIGNATURE OF APPROVING I 1 I I , OFFICER h 1 i I ocknowiedoo rece 011" 11"1 �?�11,114Id for I orhoom above. pt ei the funds puroosolletetedI e the aflame and at accounted here. for I CERTIFY FUNDS ARE AVAILABLE 1 1 li 1 I 'DATE I AMOUNT I on GAT I ON REFERENCE NO. CHARGE ALLOTMENT NO. CERTIFIED FOR PAW/ENT OR CREDIT 3325.4390.3902 11 1 DATE I AUTHORIZED AUTHORIZED CERTIFYING OFFICER SIGNATURE OF ADVANCEE 1 I I H I DATE SIGNATURE I I I I I I I I I I I I 1 I I SPACE BELOW FOR1EXCLUSIVE USE OF FINANCE DIVISION i 1 P.EPARED OV ' I I REVIEWED NY VOUCHER NO. 7.12 -DESCRIPTION-ALL OTHER ACCOUNTS 3.33 34.19 ,.., .. 4$.46 47-52 53 S6.671 66.70 71.60 1 AND-02/8 . ***** " ' ' ' ' ' '''''' S T AT ON cope " "v.". EVENO ' 4 u FAY FE"' 0121 i G. REF. NO. SA- 57' 1 GENERAL II ACCT. NO. I DATE AN UN DESCRIPTION- ADVANCE ACCOUNTS 111 .27 P.O. NO. ....I... ' . PPIOP.NO. ' ........1..1 CODE I N D I.110. ' loil&r4.4,6/i: ' ' ' ' ' ' - " LEDGER : .2.14!.: 4 :, ' I �INJECT 115i.ii 11 1 Igo", JOECV NO. I i v cor,E 1 7 (NT 'do. ii ACCT. II 11 NO. , rx recrl NO. CLASP OCOOP CPCO17 II1 1 11 1 1 1 1 1 1 11 1 I 1 1 1 111,1111 111114 1 I I 1 I 11 I 1 Cili 7 I. I 11 X *a 4. dro.00 9 1 1 , 1 , I I 1 1 1 1 1 1 1 I I I I I I 111 I I I 1 4411 I II I 11 I 1 I 11 11 ,-.., "��'" r711-, '-t 1 11-� /1 ii Illi 6, � .. .... Hr., vp. i ciF ri- 1 I- I 1 , I I I I I I I I I I "III" I 1 II 1 1 i 1 ili 1 a 1 1, i ii 1 III.' I 1 1 -1 1 [ ' 1 I i t 1 1 I III 1 I' 1I 111 ill 11 I IIIII11 II 1111 , p 0 'Nk. II I r i 1 1 - TOTALS' 1 i FORM ,,,,,. 0.60 �02 N9E PPZVIOUP POIVIONs. .' SECRET I (36-40) 77/1 109 Atithorits 1 ii Novak ion #=3 _ r 1 $21,080.0 / 3125-1390=3902 :7.".t MEMORANDIALFOR : THE -RECORD SUBJECT_ MKULTRA,- Saproject 109 . /07--"C DRAFT 15_NoveMber 1962 1,The purpose of-thiasubproject is to provide funds fOr the continuation of a study Of potential psyd4opharMeco1ogical agente-In particular, studies will t directed-to the elusidttion--- _I of interrelationships between molecular-constitution and biological response. Studies will-be conducted into the :biochemical charac- teristiesof_tertain types of Chemical moietiesTwhich_are of:in-_ _ terest_to :TSD/5B in carrying out its program onAhe_development of means to_control Hula Behavior. 2 The attadhed BVIdget indicates the extent of the inYc6ti', gations-that vi11't4 carried out under the direction of Dr. n facilities available at th- funda-for_this_project vill-be transferred using the as a cutout. 3,7-The�studies being carried out under this subproject-wre originally planned to cover speriod-of approximately five years Based upon the attached proposal. However, the_change in emphasis /09 of the present TSD program requires_tbat these plans-be altered 7 - considerablyThe-investigation has therefore agreed to pro- duce as many actualTend-item:compoundeiat-possible during the next year-and_also-to consider this us the final:year:of the project� FOrthis reason the attached budgetlaas�been-scaled - down gnal te of to421,080,00,_ The lowerfigure reflects mostly-lowered personnel -costs occasioned by-the-siMpler developmental activities7now planned, 4. The cost of-this program for a periodct-one _ not exceedi$2406M0 tO-Which must be added tpie_four per Cent fee toAhe trig the total amount121,92Y20. . Charges-shouldba-Made against Allotment No. 3125-13907390271-' 5;� The submit to them a summary accountingon7Aniannual-basis of all_monins-received-from the be returned_by th of thegrant:year._ 6.__A requirement fora six months'-infOrmal accounting on the part_orthe-principal investigator Is waived. 7. - Iti8not anticipated-that-any-permanent_equipment will be needed-for_this program. Also, unexpended funds %fill as soon as possible -upon the close 8. In connection-vith travel under this project, it is agreed th tatie Agency will accept travel documentation and accounting which:Conform with the practices of the 9. It-is agreed that technica1-4�--eports reflecting the progress_of the research-program-shall-be submitted at-mutually acceptableA.nterwals. 10._ All personnel conve-cted with the planning_and mon- itoring of_this program -possess TOP-SECRET-Agency security approval. 11. This project will be unclassified afr�it leaves the Attachmentl Proposal & BUdget Distribution. -- Original only BIOLOGICAL BRANCH P 3 BY TH AT_THE PROPOSED RESEARCH-PROJECT---. PPORTED 7- - ye Ju y , 1960) Project Title: The_Synthesis and Biechemical Evaluation of I Potential Psychopharmaco- logical Agents. Principal investigator: Ph.D., Professor and-Head of the Department - -Pharmaceu teal and Medicinal Chemistry, College of Phar- macy.* For the past several_yeara;_theTapplicant has-beetkengaged'in-research-involving-- (I) the synthesis of=organic-entities having potential effects upon the central ner- vous system, and (II)-the evaluation of connections between-the-CheMiCalvand-pharMa--i codynamic properties�of�theteaf4Oundhe-applicant is primartly-interested-in _ the fundamental studyoffreltibnahipabetween molecular constitution and biochemi' cal response, and isparticularly-ooncerned with theeffeCtof=gradmal Changes_01� the chemical structure-of-tynthetlo-entities:upon isolated t' ste s . e rea- d referred to .(A)_reports_aubmitted earlier to the and (B) publiShed accounts 849 for supplemental inforMation. .. The applicant plansto_conttnue hia-iffiestigation in accordance-with-the princiPles set forth in the citeditommunications. Specifically, he intends-to: 1. Synthesize severaLiii�of-new compounds patterned afteri(a)nrganic amines known to affect=the_central nervous system,_and_(�) _moieties-acknowledged as sub- strates in enzymeTsystems-implicated-in7the pharmacodynamics_oVcompoundslposAes'!____ sing psychopharmacologiCal-properties. The member compoundi-of-each series will be designed withfgradual changes in-theit-conatitution, or-physical properties, - or both; furthermoreitheyiwill-be planned in such a mannerthat potential diffe- rences in the interaction between the member compounds of a given-synthetie-Serftl----- and a given enzyme-Allay be-interpreted in terms of concepts reasonably well estab- lished in contemporary theoretical chemittry.--- 2. Study the effect:_ofthett-entitiea-OpOn'(a)-iSolated enzyme7preparatiowbelieVed: _ to be associatedWith_brain-funetien,-And (b) other-plausiblehlochemical systems. 3. Explore relationships between-the biochemical activity-of each series of derivatives, and the successivechanzes in the physical _characteristics of the member compounds. At present, our synthetic work-is-Centered-around series-of arylalkylaminoalkylacete..." mides, and pyridine�and_piperldinecarboxamides which _could be visualized-aa-moieties---- derived from the psychotomimeticrtelecule LSD (see Figures I,II, III and IV; other series have been planned). Concurrently, the completed compounds are being evaluated in isolated cholinesterase systems in which LSD has shown-remarkable specificity. Our manometric-procedures * Effective July 1,--1960 (on-leave-of absence July 1,1960 through-June-30 1961). Page 'INK. LSD: RN .�" 1. A \"! LSD: of� N �C H 26 / CH CH-3 A FTGURE I. . 0 U C -C2H5 / 2_- SUBST I TUTED ARYLALKYLAMINOPROPIONA ,C2N5 C.41 3 0 )4N5 c-041F1 1 * I I c 113C. N 71 0 N211 GA-93 NC2h5 LSD CH30 CH ON IDE ANALOGUES 0 0 /c015 C -0 -N.., 11 "s1C2N5 C /, 1,11 N �104 1 CH3 PI CO C 11303 N3C0 N3C0 H3C0 GA-143 GA�I65 e. Page Four. ...'��-� St --.40 2ip - I a, I��VS F---k--. a .Y. la do 1 t � -V V - �.t. I .41 V-IT--- I� 4 � 4.. � I :1)th 1 * 1 1 LLI 41,-*Z.�� / P- Page Five 0-H II I C-N-CH N CH FIGURE7TY. CH3 ces Ceis /oP. MY-76 Page Six yield very precise measurements of activity-in isolated pseudo- and acetylcholines- terase systems, and enable-usitoevaluate the significance of even-minor variations in activity due to small constitutional-Changes in -A aries-0Oleedles. _ We are aware of the fatt-that-the-_effectiveness-of-a-psychopharmacological-agent-in _ vitro cannot be interpreted as evidence for the inVelvement oLth_emspecific enzyme in the mechanism of psychotomimetic-responses. Yet even without conclusive causal- - connection, this approach may furnith-va-1U-able informatiOn-66 the nature of-17,sychoa- pharmacological agents ------== * * * It is felt that this investigation may yield (a) information assis_t_ing-the eludida- tion of interrelationshipSibetWeen_molecular constitution and biological _response, (b) better insight intothe biocheMical ch-gteristics-and therakeutic_poten_tiali- ties of certain typeSofmoi-ec) several series of new organie7compounds.-4nd information about their_phytical CharaCteristics, and (d)-datas_upplement_ing'Our: knowledge of the neurochemical processes-associated-With-thtactiontoftpsychOpli-arma- cological agents. * * * The references cited in-the-first paragraph of the outline areliated_on the --- ing page. January 22, 1960 cc: 701- Page Seyen . ^ -1. First Annual-Re tt to th June 1955, 2. 3. 8. 9. 10. 11. 12. 13. 14. 15 16 19. Third Report to_the in preparation em er May 195 Second ecember 1956 Fou R.ort to the y 1959 Nay 196 eve to the . Chem., 21: 799, 1956.. Org. Chem., 21: 805, 1956. J. Org. Chem., 21: 958, 1956. J. Org. Chem., 22: 837, .1957. J. Org. Chem. � 23: .1577, 1958. J. Org. - Chem. , - 23: -2005, 1958.� MarAssoc.) Sci. Ed Abstracts, Am. Soci-Pharmacol. Nature, 184:1922, 1959., astry, J. mcd. pharmi-Chem.4 in press, med. pharm. Chem. : in press,-1960. / � PROPOSED -BUDGET-FOR-RESEARCH PROJECT: BY THE AT (Dece roug ovem , 19 Project Title: The_Synthests and Biochemical Evaluation. of Potential Psychopharmacological Agents. Principal Investigator: .D., Professor -and Chairman 0 the epartment of Pharmaceutical and Medi- cinal-Chem-i-stry, College of-Phermacy._______ Personnel (Associates,_Assistants and Consultants) . Supplies and Materials Travel SUBTOTAL I 7% of Personnel Budget ($�0Oiito cover retirement, etc. $: 1.2l000.00 $. e90.44if $ 600.00 $ 3.711496:414- SUBTOTAL II $ 18,330.44 _ 15% of Subtotal II ($ 18�.330.114 participation in indirect costs o cover $i--7 2,714.56. .TOTAL $ 4,080.00 * * * Checks should be payable to the May ii, 1962 /c1-= /v. Date- Vareaber Branch__ Category_Segivitn Predi-Maa andCO4tt (V ) fiyatheal uatioa of Pettattial Payel2i0asteswLagiall. CoVeugulli Project Title Item Classification___Aboummitruptl_____ Project CtyptoMISRA Branch Project No Cr-ypto.ClasstficationalThid___ Preject 'Br�cgincer__ I Contract _ T1 No Type of Contract-444. Purposl: Status: -- 1 Dat& IrUtiatec 5.11: 421AblY11 Con�ipletion Date1 altict4ation or lawrrelaticosbiporaittltion- toolftular tonstitutica Vial leal-4-aiipctits-af�abrateal, 0040414 of Atitareat W TEO. 1 BMWS interestly jtrsted in Tee by Seed for. sLul bialoi; rally aetive eaarvourode azd Ir4ers/m.14* aa their chataatetaltation. Dear I certainly_enjoyad'talking to you this morning. For yOunconvenience, 1 am-enclosing -Copy_-of_the proposed_budget for_the next grant pCriod_(December I, I962�th-rough-November 30, 1963). With the very best regards, Enclosure By Air Mail P.S.: My home address is: 1862 AMERICA'S LAND-GRANT UNIVERSITIES CELEBRATE A CENTURY OF-SERVICE 1962 TO THE (Deoe er 30-19 Ph1,1).-,.Professor and Chairman of - e epartment Of'Pharmaceutical and Medicinal Chemistry, College-..0f=Phtmaty * * * May 31, 1962 $ 3,000.00 41) PROPOSAL FOR ESTABLISIDH,NT OF_FACILITIES-FOR :PSYOBCrTO14ThTWDRUQ TEST First Year: fal=m1m� Literature revielf- SuveyotpQmiairg MOS � Iris' to sourceseminars suggestions 'Practice" trialsreproduce-established results Effects to be-screened:- convulsante --anticonvulsants specific -arterial_d ilators - cons tritor s antiserotonin _effect cholinesterase-inhibitors BUDOET,-DIITIAL STAFF Neurologist -r-incipal_investtga,tor $ 3,000 Clinical pharmacologist 111,000 Research assistants 10,000 Statistician services (part time) - --- 1,200 Resident assi,nments(ELrio.-$300/ino.) . 2,1400 F,quipment and supolies _ e.g. calculator, camera, EalsCr� service, computor service 4,000 Travel 600_ To-t41 $35,200 To the budget figures must-be-added 7% of personnel budget for retire- ment and 15% of overall costs-for overhead.- /07-4 FACILITIES FOR-PSYCFMONDIETIC DRM TESTING (CONTINUED Second Year: .Glikalmelk�amB Trials_cfr com ounds Screening potentially valuable effects Chronic toxicity in_antr,als Human trials - double blind-and/or concurrent tria16f- psychological effects autodomic7effects anticonvulsant -------- entispasmodid anticholinesterase (liMited, on myasthenia gravis-patients) antiserotonin-('olustern headaches) BUDGET - &MOND-YEAR STAFF Neurologist - principarinvestigator $1;000 14;000._�_ Clinical pharmac-ologit_ __ Experimental OsycholOgist 10p00 Research assistants-- ----- 10;500 Statistician services- 1;200 3,000 Clerk-statistdeian Resident _assignments 3,600 5,000 Equipment and suppl a'(including animals and care) Travel 1400'- (+-7% personnel for retirement) (+15%7overal1 for overhead): It may be advisable_alsoito-consider the addition of a bas c7pharma4-, cologist to the staff_in second (or third) year. Attentiu Deer Sir t Mar ch_9, -1962 =-__ _ Enclosed-is7the- cumulative annual expenditure report - on your_Drant_to Pr. This is for the period July 1, 1960, to r!Ov?-..r 30,,61 Yoursvery truly, 1862 AMERICA'S ND-GRANT UNIVERSITIES -CELEBRATE A-CENTURY OF SERVICE 1962 (Ju1y_1,:1960 throu9h-Novembe_r730, 1960 Project Title: The Synthesis-and-Biochemical-Evaluation-of-Petential Psychoph macologicalt Agents Principal investigator: Ph.D., Professor and Head fJtherDepartmentIofii f ?harrnaceutical and_MedidihalZChemistry,-College of Pharmacy Date: November 30, 1961 _ Outstanding_Unencumbered Item _ Aocropri-atien-Pa -ments=_Ercumbrances._ Balance Personnel: Principal Investigator $ 3,000.00 $ 3,000.00 $ -0- -0- 0 0- Associates, Assistants &Consultants--- 1,077;00-- 1_1077-.00 -- - -0- -0-- Supplies and D,laterials 77,061.55 7,061.55- Equipment 6,324.-93-6,32,4-.93 -0- -0------- Travel 581-.57 - 581.57 -0- -0- Subtotal: $18,SY15,05 $18,045-.05 $ 285.39 - 285.39- -0 -0- 77; of Personnel Budget; to cover Ret.-Soc.Sec.-Ins. 15% of Entire Budget; to ;cover �� -0- Indirect Costs Total: $21 080.00 $2-1-.080.00 $-0- I have exad d apn1v=!.,3. the submit expenditure:, SiCliznioal Date: NV, i 29 March 1962 MEMORANDUM FOR: The Record 7-. SUBJECT_ : MKULTRA, Subproject 109, Cost of Equipment Exceeded Budget-Estimate 11The BI.Tdget Proposal for Subproject 109, dated 22 January 1960, had a proposed figure of $5, 000.100:for supplies_a.m1 materials . There was no anticipation of any equipment 2-. An accounting report has been received for the period_1_In1y_1960 through 30 November 1961. This report reflected expenditures of-$7, 06155 for supplies-and materials, and $6, 32493 for equipment. These amounts-exceeded the figures in the original proposed bUdget. 3. This equipment was expendable and the_expendiIII - tures have-the approval of-TSD/RB as being essential for the successful completion of the research work-that was conducted. March_9, 1062 Dear Sir I-- Enolosed_is the on your grant�to CP. July 11 1960i-to Nove nual expenditurirreport This is for. the period Cost�Aceburit I/ /0 � - � Object Class � Date Remarks:And ReferenceS Obligations= Obligations Unliquidated Incurred Liquidated Balance 15'31 166V; tol u�lie 04346 ,c4f/e a Date: MEttIORANDUM FOR; 'T.. C0141-:_)TROLLER ATTENTION Finante Miele SUBJECT ; IVIKULTRI Subprolect Uncler th�e authority graritf.,..d ri-lernorau:lure. ad 13 April 1953 _ from the Doi to the OD/A, and tho tensiGn of tbio authority in oubsequ memoranda, Subproject_i1 hag be aoprovocA, and $25, 043. 20 of the ovz.,,r-c,-,11 Projet t ivf:t:ULTEtA-funds havii beeii_:-.1bligo`,,ted to cover -the subproject 'ae puics anci sho-orLbe_chargee to cost. ce,rit _ 2125.1311�322a , APPROTED FOR OBLIGATJON OF FUNDS: Re:Ilezrch ihreztor Date.; Digtribtlti OriginZ1 Addrease T. -=TSD/FASS TSD/RB MEMOAANDUM 0 chia.- nCe DLitt VIA SUBIECT 13_11ovetnbs r 1941 TSD/1144iat Officer MKULTRA,-SarprOject 14)9, Iwo Aliottneiit No.-212543901.3902.-- /0 L ktvolcizto. 1 cayering thc above fubproject la attache Payenoat s mad be, (:).14,2- u (0114./WC Casblerti_ drawn_ Ca 12 tof-SZ.1 08 .01. . atnatuat o 63 2 dravia yable to Pleaforwari the c ecks , 'Lli;Dhles *arch Branch throtqh TSD/Blidget Officer by 28 Novcntbcr 1961. 3. This is a final invOiCe. However, nce it is aatiatpatod that adtittionat_inada will b4 -obligated for this projectl- the files ehould not be closed. Attachfr.ent: Iavoice Ii' ens Distrit.-mtioa; Orig. k � Addressee TSD/FASS � 770 Z. g TSD/R.B RECEIPT Receipt is hereby_acknowledsed for_thefollowing two checks: /0 Casbierge_Check-NOr. �ated November e siountof- payable t on NaTne ate ),IEMOWIDUM Chief, VIA ?SO/Budget Officer rcibe I /07--- 2- SUBJECT I _ MIcULTR.Subproject 109, Invoice No. Allotment No. 2125.1390-3902, 1. lavotce No. 1 coverIa, the ab.oio etibpoject i attacbed. Pay oat should be made as follows: Cashier's check In amount of $24,0 00) drawl Ca shier 's 2�__Piesse forward the ch eke te Chief, 'ND/Research Branch throtigh T813/13U4set Officer by 28 November_l96L__ 1, This is a final invoice. However, since it is anticipated that additional Ands veill be_obliaated for this project the files should nOt be closed. TSD/itsecarch Brita Attachment: Invoice te Certifications Distributiont Ori Z � Achit4esott j TSD/FASS =-TSD/Ril /07- 2.3 1NVOIC CEIV ..TICATIONS 11) hti41); thag th-;.5 ;Iftvetp_, 11-1' g S4Ab=p7t03t.t N. 109 k NIKULTRATINd-pezicitxtvkatt iFvt.ti*Lattue _ tti?7,t alt:-.tonp24.41:htP-1 ,I,uc-c.rd41.4.coT with rsloaKA1 tit,t411.7td. 32endA 11.!v prAyt1ent4 464d res;,cipt,s c.,-n fill %;�ti hill isj&i d4:-..c.xrect A.3.0 Atvt;i: spiwavott that - _ A4 Zoffi yet ISO/RtIoe4rce.tz Bruxh, 004 113 November 1961 tvert,,by ..certlite4 tkAt thi.i invtqcoppii4 ta Slibuivolttt wiKis:4A '41+6. duly apprcv-ttis. ..4114:1 that the: project it brAng titd 4.:�?-atel.aaii_Ie with tfw rnecoc�rmd5.ttn tl 13 April 1953 from 18-,5 01)1A., &pd tht., extm,Ivicra

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MKULTRA SUBPROJECT 109 (31 DOCUMENTS WITH PUBDATES FROM 600219 TO 65092 0)